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https://www.readbyqxmd.com/read/29660382/elevated-plasma-soluble-pro-renin-receptor-levels-are-associated-with-left-ventricular-remodeling-and-renal-function-in-chronic-heart-faiure-patients-with-reduced-ejection-fraction
#1
Linghui Gong, Shenglin Zhang, Linrui Li, Xin Gao, Dongxia Wang, Dachang Wu, Ke Wang, Yan Liu
Soluble (pro)renin receptor [s(P)RR], which is generated from cleavage of (P)RR, can be detected in plasma and urine. s(P)RR levels can reflect the severity of some diseases, such as renal lesions, gestational diabetes mellitus or hypertension, and obstructive sleep apnea syndrome. However, the relationship between s(P)RR levels and the severity of chronic heart failure remains undetermined. We studied s(P)RR levels in 118 patients with chronic heart failure with reduced ejection fraction (HFrEF), including 86 without renal dysfunction (HF) and 32 with renal dysfunction (HF + RF), and 28 healthy subjects (HS) to reveal the relationship between s(P)RR levels and other HFrEF parameters...
April 13, 2018: Peptides
https://www.readbyqxmd.com/read/29650354/risk-factors-for-postoperative-delirium-in-patients-undergoing-free-flap-reconstruction-for-oral-cancer
#2
T Makiguchi, S Yokoo, J Kurihara
The aim of this study was to investigate risk factors for postoperative delirium in patients undergoing free flap reconstruction for defects after oral cancer resection. This was a non-randomized, retrospective cohort study involving 102 patients who underwent oral cancer resection and free flap reconstruction. Data were collected from the medical records. Postoperative delirium occurred in 34 patients (33.3%), of whom 27 were male and seven were female. High preoperative total protein and albumin, diabetes mellitus, history of smoking, use of hypnotics or antipsychotics, time until getting out of bed after surgery, and postoperative insomnia were significantly related to delirium in the univariate analysis (P<0...
April 10, 2018: International Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/29626584/maternal-gestational-diabetes-and-long-term-respiratory-related-hospitalizations-of-the-offspring
#3
Omri Zamstein, Eyal Sheiner, Tamar Wainstock, Daniella Landau, Asnat Walfisch
AIMS: To assess the implications of gestational diabetes mellitus (GDM) on long-term respiratory related hospitalizations of the offspring. METHODS: A population-based cohort analysis including singleton pregnancies delivered between the years 1991 to 2014 in a tertiary referral hospital was conducted. Incidence of hospitalizations (up to age 18 years) due to various respiratory diseases was compared between offspring of GDM-complicated pregnancies and normoglycemic pregnancies...
April 4, 2018: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29599801/continuous-flash-glucose-monitoring-in-children-with-congenital-hyperinsulinism-first-report-on-accuracy-and-patient-experience
#4
Hussain Alsaffar, Lucy Turner, Zoe Yung, Mohammed Didi, Senthil Senniappan
Background: The factory calibrated FreeStyle Libre (FSL) flash glucose monitoring system has been recently introduced for use in patients with diabetes mellitus. There are no reports available regarding its use in patients with congenital hyperinsulinism (CHI). We have assessed the accuracy of FSL compared to the finger prick capillary blood glucose (CBG) over 2 weeks period in patients with CHI and evaluated the parents' experience of using FSL. Methods: Four hundred sixty-seven episodes of CBG along with corresponding swipe FSL readings were available from 11 children with CHI (0...
2018: International Journal of Pediatric Endocrinology
https://www.readbyqxmd.com/read/29590381/the-circadian-rhythm-related-mtnr1b-genotype-gestational-weight-gain-and-postpartum-glycemic-changes
#5
Hoirun Nisa, Kevin H T Qi, Junhong Leng, Tao Zhou, Huikun Liu, Weiqin Li, Leishen Wang, Nan Li, Gang Hu, Lu Qi
Context: Disturbed circadian rhythms and sleep quality during pregnancy have been related to gestational weight gain and gestational diabetes mellitus (GDM), which affect postpartum glucose metabolism and future risk of type 2 diabetes. Objective: We assessed whether the circadian rhythm-related melatonin receptor 1B (MTNR1B) genotype was associated with 1-5 years of postpartum glycemic changes among women with a history of GDM; and whether gestational weight gain modified such associations...
March 23, 2018: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29589988/laparoscopic-sleeve-gastrectomy-for-morbid-obesity-at-a-veterans-affairs-medical-center
#6
Matthew Skancke, Clint Schoolfield, Robert Grossman, Jennifer C Kerns, Nicole Abel, Fredrick Brody
BACKGROUND: Class III obesity is a global health emergency associated with an increase in the incidence of many other diseases such as type 2 diabetes mellitus, hypertension, hyperlipidemia, cancer, obstructive sleep apnea, nonalcoholic fatty liver disease, osteoarthritis, infertility, and mental health disorders. Minimal work has been published regarding the efficacy of laparoscopic sleeve gastrectomy (LSG) in the veteran population to surgically manage morbid obesity. DESIGN: Retrospective analysis of LSG performed at a Veterans Affairs Medical Center (VAMC) between 2010 and 2017...
March 28, 2018: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
https://www.readbyqxmd.com/read/29580302/determinants-of-poor-sleep-quality-in-elderly-patients-with-diabetes-mellitus-hyperlipidemia-and-hypertension-in-singapore
#7
Grace S H Chiang, Brenda L H Sim, Jeannette J M Lee, Joanne H M Quah
AimThe objective of this study was to assess determinants of poor sleep quality which is an under-diagnosed and under-treated problem in elderly patients with diabetes mellitus, hyperlipidemia and hypertension. BACKGROUND: Poor sleep quality is linked to decreased quality of life, increased morbidity and mortality. Poor sleep quality is common in the elderly population with associated cardiometabolic risk factors such as diabetes, hyperlipidemia and hypertension. METHODS: This is a cross-sectional study undertaken in the primary healthcare setting (Singhealth Polyclinics-Outram) in Singapore...
March 27, 2018: Primary Health Care Research & Development
https://www.readbyqxmd.com/read/29568240/differential-impact-of-diabetes-mellitus-on-antiplatelet-effects-of-prasugrel-and-clopidogrel
#8
Satoshi Niijima, Tsukasa Ohmori, Kazuomi Kario
Background: Although prasugrel exerts stronger antiplatelet effects compared with clopidogrel, the factors affecting platelet reactivity under prasugrel have not been fully determined. This study aimed to find the novel mechanistic differences between two thienopyridines and identify the factor that influence platelet reactivity to each drug. Methods: Forty patients with stable angina who underwent elective percutaneous coronary intervention were randomly assigned to receive either prasugrel (20 mg) or clopidogrel (300 mg) as a loading dose...
2018: Thrombosis Journal
https://www.readbyqxmd.com/read/29557074/common-sleep-psychiatric-and-somatic-problems-according-to-work-schedule-an-internet-survey-in-an-eastern-european-country
#9
Bogdan I Voinescu
PURPOSE: A wide range of health problems was investigated, aiming to identify the presence and severity of a set of self-reported and common sleep, psychiatric, and somatic health problems among working professionals in four different shift schedules (morning, evening, rotating, and day) in several cities in Romania. METHODS: A heterogeneous sample of 488 workers of different professions completed online a battery of tests, namely the Basic Nordic Sleep Questionnaire, the Parasomnia Questionnaire, the Epworth Sleepiness Scale, and the Patient Health Questionnaire, designed to identity symptoms of insomnia, sleepiness, snoring, parasomnia, as well as of depression, anxiety, eating, somatoform, and alcohol use disorders, respectively...
March 19, 2018: International Journal of Behavioral Medicine
https://www.readbyqxmd.com/read/29544027/the-molecular-clock-as-a-regulator-of-%C3%A3-cell-function
#10
EDITORIAL
Akihiko Taguchi, Yasuharu Ohta, Yukio Tanizawa
Type 2 diabetes mellitus is characterized by the loss of ß-cell function and mass, resulting from interactions between genetic predisposition and various environmental factors1 . One environmental condition identified as a risk factor for type 2 diabetes mellitus is circadian rhythm disruption, which is induced by shift work or sleep disturbance. However, the mechanism whereby circadian disruption leads to impaired glucose metabolism is not well understood. This article is protected by copyright. All rights reserved...
March 15, 2018: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/29526681/sleep-duration-obesity-and-insulin-resistance-in-a-multi-ethnic-uk-population-at-high-risk-of-diabetes
#11
E M Brady, D H Bodicoat, A P Hall, K Khunti, T Yates, C Edwardson, M J Davies
AIMS: Investigating the association between sleep duration, obesity, adipokines and insulin resistance (via Leptin:Adiponectin ratio (LAR)), in those at high risk of type 2 diabetes mellitus (T2DM). METHODS: Adults with impaired glucose regulation (IGR) were included. Fasting bloods for inflammatory biomarkers and glycaemic status, 2-hour glucose, anthropometrics, objective physical activity, and self-reported sleep were collected. The average number of hours slept in a 24 hour period was categorised as ≤5...
March 8, 2018: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29518206/the-science-of-obesity-management-an-endocrine-society-scientific-statement
#12
George A Bray, William E Heisel, Ashkan Afshin, Michael D Jensen, William H Dietz, Michael Long, Robert F Kushner, Stephen R Daniels, Thomas A Wadden, Adam G Tsai, Frank B Hu, John M Jakicic, Donna H Ryan, Bruce M Wolfe, Thomas H Inge
The prevalence of obesity, measured by body mass index, has risen to unacceptable levels in both men and women in the United States and worldwide with resultant hazardous health implications. Genetic, environmental, and behavioral factors influence the development of obesity, and both the general public and health professionals stigmatize those who suffer from the disease. Obesity is associated with and contributes to a shortened life span, type 2 diabetes mellitus, cardiovascular disease, some cancers, kidney disease, obstructive sleep apnea, gout, osteoarthritis, and hepatobiliary disease, among others...
March 6, 2018: Endocrine Reviews
https://www.readbyqxmd.com/read/29517624/sleep-quality-in-patients-with-rotator-cuff-disease
#13
Michael S Khazzam, Edward P Mulligan, Meredith Brunette-Christiansen, Zachary Shirley
BACKGROUND: Little is known about the influence of rotator cuff pathology on sleep. The purpose of this study was to determine which patient-reported factors correlate with sleep disturbance in patients with rotator cuff disease. METHODS: A nonrandomized, cross-sectional cohort study was performed to evaluate the effects of rotator cuff disease on sleep quality. Data collected at time zero (before any treatment) included the Single Assessment Numeric Evaluation rating, the American Shoulder and Elbow Surgeons score, the Pittsburgh Sleep Quality Index, patient demographics, and medical comorbidities...
March 15, 2018: Journal of the American Academy of Orthopaedic Surgeons
https://www.readbyqxmd.com/read/29489913/prevalence-sleep-characteristics-and-comorbidities-in-a-population-at-high-risk-for-obstructive-sleep-apnea-a-nationwide-questionnaire-study-in-south-korea
#14
Jun-Sang Sunwoo, Young Hwangbo, Won-Joo Kim, Min Kyung Chu, Chang-Ho Yun, Kwang Ik Yang
OBJECTIVE: To determine the prevalence, sleep characteristics, and comorbidities associated with a high risk for obstructive sleep apnea (OSA) in the Korean adult population. METHODS: We analyzed data from 2,740 subjects who responded to a nationwide questionnaire survey of sleep characteristics. Those who qualified under two or more symptom categories of the Berlin questionnaire were defined as "at high risk for OSA". We investigated their socio-demographic information, sleep habits, and medical and psychiatric comorbidities...
2018: PloS One
https://www.readbyqxmd.com/read/29474482/prevalence-of-several-somatic-diseases-depends-on-the-presence-and-severity-of-obstructive-sleep-apnea
#15
Ragnhild L Tveit, Sverre Lehmann, Bjørn Bjorvatn
STUDY OBJECTIVES: The objective was to investigate the prevalence of heart attack, angina pectoris, stroke, hypertension, diabetes mellitus, chronic obstructive pulmonary disease, asthma and obesity in relation to the presence and severity of obstructive sleep apnea. METHODS: The sample consisted of 1887 patients, with mean age of 48.6 years (range 16-83 years), referred to a university hospital on suspicion of obstructive sleep apnea. The patients filled out a questionnaire asking whether they were previously diagnosed with the comorbidities in interest...
2018: PloS One
https://www.readbyqxmd.com/read/29473870/prevalence-and-gender-specific-influencing-factors-of-hypertension-among-chinese-adults-a-cross-sectional-survey-study-in-nanchang-china
#16
Hui Zhou, Kai Wang, Xiaojun Zhou, Shiying Ruan, Shaohui Gan, Siyuan Cheng, Yuanan Lu
Hypertension has become the leading cause of death worldwide; data on hypertension among Nanchang adults are sparse. The aim of this study was to investigate the prevalence and gender-specific influencing factors of hypertension in adults in Nanchang, China. A cross-sectional survey was conducted with a representative sample of 2722 Chinese residents aged 18 years and above between May and September 2016, with a response rate of 92.4% (2516/2722). A stratified cluster sampling method was adopted in this study...
February 23, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29470498/u-shaped-association-between-sleep-duration-and-urinary-albumin-excretion-in-korean-adults-2011-2014-korea-national-health-and-nutrition-examination-survey
#17
Ji Hee Yu, Kyungdo Han, Nam Hoon Kim, Hye Jin Yoo, Ji A Seo, Sin Gon Kim, Kyung Mook Choi, Sei Hyun Baik, Nan Hee Kim
Although sleep duration has been extensively studied in metabolic diseases, few studies have investigated the impact of sleep duration on chronic kidney disease. The aim of this study was to examine the relationship between sleep duration and albuminuria in the general population. Among 24,948 adults who participated in the 2011-2014 KNHANES, a total of 19,994 subjects were included in this analysis. Subjects were categorized into the following five groups according to self-reported sleep duration: less than 5 h, 6 h, 7 h, 8 h, and more than 9 h...
2018: PloS One
https://www.readbyqxmd.com/read/29465549/cardiorespiratory-parameters-and-glycated-hemoglobin-of-patients-with-type-2-diabetes-after-a-rehabilitation-program
#18
RANDOMIZED CONTROLLED TRIAL
Natália da Silva Freitas Marques, Luiz Carlos de Abreu, Bárbara Vieira Dos Santos, Cândido Ferreira Rodrigues Neto, José Rener Cordeiro da Silva, Karine Ketlem de Souza Braga, Kariny da Silva Uchôa, Laila Maria Silva Moraes, Leillane Cristina de Paiva Ferreira, Natanael Guimaraes Ribeiro, Savio Lima Dos Santos, Tayná Almeida da Silva, Paulo Evaristo de Andrade, Rodrigo Daminello Raimundo
INTRODUCTION: Cardiovascular autonomic dysfunction reflex of the pathophysiology of diabetes mellitus (DM) favors an increase in morbidity and mortality related to cardiovascular events, and for this reason has been one of the most studied clinical entities. METHOD: An experimental study of a randomized clinical trial type was therefore proposed to analyze the hemodynamic and glycemic response after the practice of a rehabilitation program in patients with type 2 diabetes mellitus (T2DM)...
February 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29458699/continuous-positive-airway-pressure-therapy-in-gestational-diabetes-with-obstructive-sleep-apnea-a-randomized-controlled-trial
#19
Naricha Chirakalwasan, Somvang Amnakkittikul, Ekasitt Wanitcharoenkul, Suranut Charoensri, Sunee Saetung, Suwannee Chanprasertyothin, La-Or Chailurkit, Panyu Panburana, Sommart Bumrungphuet, Ammarin Takkinstian, Sirimon Reutrakul
STUDY OBJECTIVES: Obstructive sleep apnea (OSA) is associated with gestational diabetes mellitus (GDM). This study assessed the effects of continuous positive airway pressure (CPAP) in obese pregnant females with GDM and OSA. METHODS: A randomized controlled trial was conducted (April 2014 - June 2016). Obese females at 24 to 34 weeks gestation and with diet-controlled GDM were screened for OSA. Those with OSA were randomly assigned to receive 2 weeks nightly CPAP or be part of a waitlist control group...
February 13, 2018: Journal of Clinical Sleep Medicine: JCSM: Official Publication of the American Academy of Sleep Medicine
https://www.readbyqxmd.com/read/29458692/effect-of-sleep-disordered-breathing-on-albuminuria-in-273-patients-with-type-2-diabetes
#20
Akihiro Nishimura, Takatoshi Kasai, Shota Kikuno, Kaoru Nagasawa, Minoru Okubo, Koji Narui, Yasumichi Mori
STUDY OBJECTIVES: Sleep-disordered breathing (SDB) can induce hyperglycemia, hypertension, and oxidative stress, conditions that are known to cause kidney damage. Therefore, SDB may exacerbate albuminuria, which is an established marker of early-stage kidney damage in patients with type 2 diabetes mellitus (T2DM). The association between SDB and albuminuria in patients with T2DM was investigated in this study. METHODS: This cross-sectional study included 273 patients with T2DM who underwent portable sleep testing and measurement of urine albumin to creatinine ratio (UACR)...
February 13, 2018: Journal of Clinical Sleep Medicine: JCSM: Official Publication of the American Academy of Sleep Medicine
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