Yurou Chen, Yulong Qiang, Jiachen Fan, Qian Zheng, Leilei Yan, Guanlan Fan, Xiaofei Song, Nan Zhang, Qiongying Lv, Jiaqiang Xiong, Jingtao Wang, Jing Cao, Yanyan Liu, Jie Xiong, Wei Zhang, Feng Li
Aggresomes are the product of misfolded protein aggregation, and the presence of aggresomes has been correlated with poor prognosis in cancer patients. However, the exact role of aggresomes in tumorigenesis and cancer progression remains largely unknown. Herein, the multiomics screening reveal that OTUD1 protein plays an important role in retaining ovarian cancer stem cell (OCSC) properties. Mechanistically, the elevated OTUD1 protein levels lead to the formation of OTUD1-based cytoplasmic aggresomes, which is mediated by a short peptide located in the intrinsically disordered OTUD1 N-terminal region...
February 13, 2024: Nature Communications