G N Zyuz'kov, E A Losev, N I Suslov, L A Miroshnichenko, T Yu Polyakova, E V Simanina, L A Stavrova, V I Agafonov, M G Danilets, V V Zhdanov
We performed a comparative in vitro study of the involvement of NF-κB, PI3K, cAMP, ERK1/2, p38, JAKs, STAT3, JNK, and p53-dependent intracellular signaling in the functioning of neural stem cells (NSC) under the influence of basic fibroblast growth factor (FGF) and FGF receptor agonist, diterpene alkaloid songorine. The significant differences in FGFR-mediated intracellular signaling in NSC were revealed for these ligands. In both cases, stimulation of progenitor cell proliferation occurs with the participation of NF-κB, PI3K, ERK1/2, JAKs, and STAT3, while JNK and p53, on the contrary, inhibit cell cycle progression...
May 9, 2024: Bulletin of Experimental Biology and Medicine