Thoranin Intarajak, Wandee Udomchaiprasertkul, Chakrit Bunyoo, Jutamas Yimnoon, Kamonwan Soonklang, Kriangpol Wiriyaukaradecha, Wisut Lamlertthon, Thaniya Sricharunrat, Worawit Chaiwiriyawong, Bunchorn Siriphongpreeda, Sawannee Sutheeworapong, Kanthida Kusonmano, Weerayuth Kittichotirat, Chinae Thammarongtham, Piroon Jenjaroenpun, Thidathip Wongsurawat, Intawat Nookaew, Chirayu Auewarakul, Supapon Cheevadhanarak
Colorectal adenomas are precursor lesions of colorectal adenocarcinoma. The transition from adenoma to carcinoma in patients with colorectal cancer (CRC) has been associated with an accumulation of genetic aberrations. However, criteria that can screen adenoma progression to adenocarcinoma are still lacking. This present study is the first attempt to identify genetic aberrations, such as the somatic mutations, copy number variations (CNVs), and high-frequency mutated genes, found in Thai patients. In this study, we identified the genomic abnormality of two sample groups...
July 12, 2019: Cancers