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https://www.readbyqxmd.com/read/28728164/disseminated-tumour-cells-with-highly-aberrant-genomes-are-linked-to-poor-prognosis-in-operable-oesophageal-adenocarcinoma
#1
Sarah Schumacher, Christoph Bartenhagen, Martin Hoffmann, Daniel Will, Johannes C Fischer, Stephan E Baldus, Christian Vay, Georg Fluegen, Levent Dizdar, Daniel Vallböhmer, Christoph A Klein, Wolfram T Knoefel, Nikolas H Stoecklein, Birte Möhlendick
BACKGROUND: Chromosomal instability (CIN) has repeatedly been identified as a prognostic marker. Here we evaluated the percentage of aberrant genome per cell (PAG) as a measure of CIN in single disseminated tumour cells (DTC) isolated from patients with operable oesophageal adenocarcinoma (EAC), to assess the impact of CIN(high) DTCs on prognosis. METHODS: We isolated CK18(positive) DTCs from bone marrow (BM) or lymph node (LN) preparations of operable EAC patients...
July 20, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28723743/analysis-of-hpv-distribution-in-patients-with-cervical-precancerous-lesions-in-western-china
#2
Kemin Li, Rutie Yin, Qingli Li, Danqing Wang
Cervical human papillomavirus (HPV) infection is a dangerous disease, whose subtypes exhibit different distribution patterns in particular countries, regions, and races. In this study, the HPV distribution in patients with cervical precancerous lesions in Western China was investigated to assess a probability for prevention of cervical cancer and the clinical application of an HPV vaccine in China. The retrospective study of patients with different HPV subtypes and cervical precancerous lesions, who have undergone loop eelectrosurgical excision procedure, cold knife conization, or a total hysterectomy in our hospital from January 2016 to August 2016, was performed...
July 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28722494/cost-efficiency-analyses-for-the-us-of-biosimilar-filgrastim-sndz-reference-filgrastim-pegfilgrastim-and-pegfilgrastim-with-on-body-injector-in-the-prophylaxis-of-chemotherapy-induced-febrile-neutropenia
#3
Ali McBride, Kim Campbell, Mohan Bikkina, Karen MacDonald, Ivo Abraham, Sanjeev Balu
AIMS: Guidelines recommend prophylaxis with granulocyte colony-stimulating factor for chemotherapy-induced (febrile) neutropenia (CIN/FN) based on regimen myelotoxicity and patient-related risk factors. Our aim was to conduct a cost-efficiency analysis for the US of the direct acquisition and administration costs of the recently approved biosimilar filgrastim-sndz (Zarxio® EP2006) with reference filgrastim (Neupogen(®)), pegfilgrastim (Neulasta(®)), and pegfilgrastim injection device (Neulasta Onpro(®); hereafter pegfilgrastim-injector) for CIN/FN prophylaxis...
July 19, 2017: Journal of Medical Economics
https://www.readbyqxmd.com/read/28720454/comparative-accuracy-of-pap-smear-and-hpv-screening-in-ubon-ratchathani-in-thailand
#4
Suleeporn Sangrajrang, Piyawat Laowahutanont, Metee Wongsena, Richard Muwonge, Anant Karalak, Weerawut Imsamran, Virginia Senkomago, Rengaswamy Sankaranarayanan
We evaluate the potential for using high-risk human papillomavirus (hr-HPV) testing-based screening for cervical intraepithelial neoplasia (CIN) in routine health services in Thailand; its accuracy in comparison to that of conventional cytology (CC); and the utility of HPV16/18 positive results and liquid-based cytology (LBC) triage for HPV-positive women in the detection of high-grade CIN. Women aged 30-60 years in Ubon Ratchathani province, Thailand were screened with CC and hr-HPV testing and those abnormal on either tests were referred for colposcopy and/or directed biopsies...
June 2017: Papillomavirus Research
https://www.readbyqxmd.com/read/28717723/cervical-abnormalities-in-south-african-women-living-with-hiv-with-high-screening-and-referral-rates
#5
Ingrid T Katz, Lisa M Butler, Tamaryn L Crankshaw, Alexi A Wright, Karen Bramhill, Dominick A Leone, Janet Giddy, Sean Mould
PURPOSE: To determine the prevalence of screening, cervical dysplasia, and malignancy on the basis of histologic diagnoses from colposcopy and large loop excision of the transformation zone among women living with HIV (WLWH) who attended an urban antiretroviral treatment (ART) clinic in KwaZulu-Natal, South Africa. MATERIALS AND METHODS: We performed a retrospective cohort study to examine a random sample of 462 WLWH during a 5-year period from 2004 to 2009. Women on ART for < 3 months were excluded...
December 2016: Journal of Global Oncology
https://www.readbyqxmd.com/read/28717277/contrast-induced-nephropathy-in-urological-imaging-a-comparison-with-cardiology-interventions
#6
Manas Babu, Devesh Bansal, Sony Bhaskar Mehta, Biju Pillai, Hariharan Krishnamoorthy, Thankachan Attacharil
INTRODUCTION: Published studies about contrast-induced nephropathy (CIN) mainly focus on cardiac intervention and rarely focus on patients undergoing urological contrast investigations. We aimed to determine the association and effect of intravenous (IV) iodinated contrast material on the incidence of CIN in a group of patients undergoing urology investigation and compare the results with that of cardiology interventions. METHODS: This prospective study was performed in patients undergoing IV contrast studies in Urology and those undergoing coronary interventions, in our institution for 1 year...
July 2017: Indian Journal of Urology: IJU: Journal of the Urological Society of India
https://www.readbyqxmd.com/read/28710822/prevalence-and-significance-of-hmga2-expression-in-esophageal-adenocarcinoma
#7
Jeffrey K Mito, Agoston T Agoston, Paola Dal Cin, Amitabh Srivastava
AIMS: Esophageal adenocarcinoma (EAC) tumorigenesis has been primarily linked to loss-of-function mutations in tumor suppressor genes. Knowledge of specific oncogenes that drive tumor progression, and their relationship to outcomes, is limited. High Mobility Group AT-Hook 2 (HMGA2) has been reported to be amplified in a subset of EACs, but the clinicopathologic and prognostic implications of HMGA2 expression in EAC is unknown. METHODS AND RESULTS: We performed HMGA2 immunohistochemistry and fluorescence in-situ hybridization (FISH) in EAC to determine its clinicopathologic and prognostic significance...
July 15, 2017: Histopathology
https://www.readbyqxmd.com/read/28709939/transdermal-delivery-of-dimethyl-fumarate-for-alzheimer-s-disease-effect-of-penetration-enhancers
#8
Dina Ameen, Bozena Michniak-Kohn
Dimethyl fumarate (DMF) is an orally administered drug with neuroprotective and immunomodulatory activities. It has potential uses in the treatment of neurodegenerative diseases such as Alzheimer's disease (AD). The objective of this study was to investigate the feasibility of transdermal delivery of DMF by studying the effect of different penetration enhancers on the skin permeation of DMF. The permeation of saturated DMF solutions was investigated in propylene glycol (PG) with varying concentrations of each of the following enhancers: Polysorbate 80 (T80), N-methyl pyrrolidone (NMP), laurocapram (Azone(®)) (Az), Transcutol P (Tc), Terpineol (Terp), and cineole (Cin) using vertical Franz diffusion cells and human cadaver skin...
July 12, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28708785/y-box-binding-protein-1-promotes-epithelial-mesenchymal-transition-invasion-and-metastasis-of-cervical-cancer-via-enhancing-the-expressions-of-snail
#9
Tianyun Pang, Min Li, Ye Zhang, Weiwei Yong, Haixian Kang, Yunhong Yao, Xinrong Hu
OBJECTIVE: Y box-binding protein 1 (YB-1) is a potent oncogenic protein. How it regulates Snail in most tumors including cervical cancer is unknown. This article is to study if YB-1 plays a role in cervical cancer via regulating the expression of Snail. METHODS: Immunohistochemical staining of YB-1, Snail, and E-cadherin (E-cad) was performed on tissue specimens including 35 cases of chronic cervicitis (as a control), 35 cases of cervical intraepithelial neoplasm (CIN) I, 35 cases of CIN II/III, 28 cases of unmetastatic cervical squamous cell carcinoma, and 19 cases of metastatic cervical squamous cell carcinoma...
July 13, 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/28708133/autoantibodies-in-chronic-inflammatory-neuropathies-diagnostic-and-therapeutic-implications
#10
REVIEW
Luis Querol, Jérôme Devaux, Ricard Rojas-Garcia, Isabel Illa
The chronic inflammatory neuropathies (CINs) are rare, very disabling autoimmune disorders that generally respond well to immune therapies such as intravenous immunoglobulin (IVIg). The most common forms of CIN are chronic inflammatory demyelinating polyradiculoneuropathy (CIDP), multifocal motor neuropathy, and polyneuropathy associated with monoclonal gammopathy of unknown significance. The field of CIN has undergone a major advance with the identification of IgG4 autoantibodies directed against paranodal proteins in patients with CIDP...
July 14, 2017: Nature Reviews. Neurology
https://www.readbyqxmd.com/read/28706398/efficacy-of-atorvastatin-in-prevention-of-contrast-induced-nephropathy-in-high-risk-patients-undergoing-angiography-a-double-blind-randomized-controlled-trial
#11
Maaz Hussain Syed, Prakash Narayan Khandelwal, Vijay R Thawani, S S Katare
OBJECTIVE: To evaluate the efficacy and safety of atorvastatin (ATN) 80 mg in the prevention of contrast medium- induced nephropathy (CIN) in high risk patients undergoing angiograph. MATERIALS AND METHODS: This was a prospective, double-blind, two-arm, parallel group RCT. A total of 216 patients undergoing coronary angiography were screened, and 188 eligible patients were randomized to two treatment arms. Patients in Group A received tablet N-acetylcysteine (NAC) 1200 mg once daily, and patients in Group B received tablet atorvastatin 80 mg + NAC 1200 mg once daily, for 3 days before, and 2 days after angiography...
April 2017: Journal of Pharmacology & Pharmacotherapeutics
https://www.readbyqxmd.com/read/28705710/using-p16-immunohistochemistry-to-classify-morphologic-cervical-intraepithelial-neoplasia-2-correlation-of-ambiguous-staining-patterns-with-hpv-subtypes-and-clinical-outcome
#12
Yuxin Liu, Mahfood Alqatari, Kieran Sultan, Fei Ye, Dana Gao, Keith Sigel, David Zhang, Tamara Kalir
P16(INK4a) immunohistochemistry (IHC) is widely used to facilitate the diagnosis of human papillomavirus (HPV)-associated cervical precancerous lesions. While most p16 results are distinctly positive or negative, certain ones are ambiguous: they meet some but not all requirements for the "block-positive" pattern. It is unclear whether ambiguous p16 immunoreactivity indicates oncogenic HPV infection or risk of progression. Herein, we compared HPV genotypes and subsequent High-grade Squamous Intraepithelial Lesion (HSIL) outcomes among 220 cervical biopsies with a differential diagnosis of Cervical Intraepithelial Neoplasia 2 (CIN 2) based on hematoxylin and eosin morphology and varying degrees of p16 immunoreactivity...
July 10, 2017: Human Pathology
https://www.readbyqxmd.com/read/28704717/implementing-community-based-cervical-cancer-screening-programs-using-visual-inspection-with-acetic-acid-in-india-a-systematic-review
#13
REVIEW
Prajakta Adsul, Nitin Manjunath, Vijaya Srinivas, Anjali Arun, Purnima Madhivanan
The objective of this review was to systematically appraise the existing published literature about community-based cervical cancer screening programs that have used visual inspection methods using acetic acid (VIA) in India. All peer reviewed journal articles till December 2015 were searched per PRISMA guidelines. Articles reporting results from cervical cancer screening programs in community-based settings, conducted in India, and using VIA were included in this review. The search resulted in 20 articles to be included in the review with a total of 313,553 women at 12 unique urban and rural sites across India...
July 10, 2017: Cancer Epidemiology
https://www.readbyqxmd.com/read/28704213/menstrual-pad-a-cervical-cancer-screening-tool-a-population-based-study-in-rural-india
#14
Atul Budukh, Vrushali Palayekar, Amita Maheshwari, Kedar Deodhar, Pallavi Purwar, Sonali Bagal, Ashok Vadigoppula, Manoj Lokhande, Nandkumar Panse, Rajesh Dikshit, Rajendra Badwe
In the rural areas of India, women generally use a piece of old cloth as a menstrual device. The aim of this study was to detect human papilloma virus (HPV) from menstrual blood on the menstrual pad and assess whether this could be a useful screening tool for cervical cancer. In Jamkhed area of rural Maharashtra, (population A), we collected menstrual pads from women who provided consent in the 30-50 year age group. The women who had provided menstrual pads underwent HC2 testing. We standardized the method for extracting DNA by PCR from the menstrual pad...
July 12, 2017: European Journal of Cancer Prevention
https://www.readbyqxmd.com/read/28700113/na-k-atpase-coupled-to-endothelin-receptor-type-b-stimulates-peripheral-nerve-regeneration-via-lactate-signaling
#15
Nguyen H Tu, Tayo Katano, Shinji Matsumura, Nobuo Funatsu, Vuong Minh Pham, Jun-Ichi Fujisawa, Seiji Ito
We have recently demonstrated that endothelin (ET) is functionally coupled to Nax , a Na(+) concentration-sensitive Na(+) channel for lactate release via ET receptor type B (ETB R) and is involved in peripheral nerve regeneration in a sciatic nerve transection-regeneration mouse model. Nax is known to interact directly with Na(+) /K(+) -ATPase, leading to lactate production in the brain. To investigate the role of Na(+) /K(+) -ATPase in peripheral nerve regeneration, in the present study we applied ouabain, a Na(+) /K(+) -ATPase inhibitor, to the cut site for 4 weeks with an osmotic pump...
July 12, 2017: European Journal of Neuroscience
https://www.readbyqxmd.com/read/28697900/the-distribution-of-human-papillomavirus-genotypes-in-cervical-cancer-and-intraepithelial-neoplasia-lesions-among-chinese-women-in-yunnan-province
#16
Li Yuanyue, Zulqarnain Baloch, Nafeesa Yasmeen, Yuan Tao, Wu Xiaomei, Xia Xueshan
This study was designed to explore baseline data about the prevalence and distribution of human papillomavirus (HPV) genotypes among Chinese women who had cervical intraepithelial lesions and cervical cancer. A total of 511 patients were recruited, and biopsy samples were collected from these patients. Polymerase chain reaction was used to detect HPV-positive samples, and the HPV GenoArray kit was used for genotyping. A total of 23 genotypes were detected, including 13 that were high risk-HPV (HR-HPV), 3 that were potential high risk-HPV (PHR-HPV) and 7 that were low risk-HPV (LR-HPV)...
July 8, 2017: Journal of Infection and Public Health
https://www.readbyqxmd.com/read/28696210/role-of-chromosomal-instability-in-cancer-progression
#17
Sarah E McClelland
Cancer cells often display chromosomal instability (CIN), a defect that involves loss or rearrangement of the cell's genetic material - chromosomes - during cell division (Lengauer, et al. 1998; McGranahan, et al. 2012). This process results in the generation of aneuploidy, a deviation from the haploid number of chromosomes, and structural alterations of chromosomes in over 90% of solid tumours and many haematological cancers (Mitelman). This trait is unique to cancer cells as normal cells in the body generally strictly maintain the correct number and structure of chromosomes...
July 10, 2017: Endocrine-related Cancer
https://www.readbyqxmd.com/read/28694260/coup-tf1-2-nr2f1-and-nr2f2-control-subtype-and-laminar-identity-of-mge-derived-neocortical-interneurons
#18
Jia Sheng Hu, Daniel Vogt, Susan Lindtner, Magnus Sandberg, Shanni N Silberberg, John L R Rubenstein
Distinct cortical interneuron (CIN) subtypes have unique circuit functions; dysfunction in specific subtypes is implicated in neuropsychiatric disorders. Somatostatin (SST) and Parvalbumin (PV) interneurons are the two major subtypes generated by medial ganglionic eminence (MGE) progenitors. Spatial and temporal mechanisms governing their cell-fate specification and differential integration into cortical layers are largely unknown. We provide evidence that Coup-TF1&2 (Nr2f1&2) transcription factor expression in an arc-shaped progenitor domain within the MGE promotes time-dependent survival of this neuroepithelium and the time-dependent specification of layer V SST CINs...
July 10, 2017: Development
https://www.readbyqxmd.com/read/28693693/can-fundus-fluorescein-angiography-be-performed-for-diabetic-patients-on-oral-metformin-%C3%A2
#19
Du Junhui, Li Rong
Metformin is a kind of biguanide hypoglycemic agent that has been widely used in patients with diabetes mellitus. In clinical practice, whether metformin should be stopped before Fundus fluorescein angiography (FFA) remains largely unclear. Some endocrinologists suggest stop metformin before FFA. However, ophthalmologists do not always adopt this opinion in their practice. This situation may lead to disputes between physicians and patients. This article analyzed contrast-induced nephropathy(CIN) and the related contrast agent, as well as the adverse reactions of fluorescein angiography...
June 10, 2017: Chinese Medical Sciences Journal, Chung-kuo i Hsüeh K'o Hsüeh Tsa Chih
https://www.readbyqxmd.com/read/28693176/flexible-magnifying-endoscopy-with-narrow-band-imaging-for-the-diagnosis-of-uterine-cervical-tumors-a-cooperative-study-among-gastrointestinal-endoscopists-and-gynecologists-to-explore-a-novel-microvascular-classification-system
#20
Noriko Nishiyama, Kenji Kanenishi, Hirohito Mori, Hideki Kobara, Shintaro Fujihara, Taiga Chiyo, Nobuya Kobayashi, Tae Matsunaga, Maki Ayaki, Tatsuo Yachida, Ayako Fujimori, Makoto Oryu, Chiaki Tenkumo, Megumi Ishibashi, Uiko Hanaoka, Toshiyuki Hata, Yumi Miyai, Kyuichi Kadota, Reiji Haba, Tsutomu Masaki
Narrow band imaging with magnifying endoscopy (NBI-ME), which is useful for the assessment of micro-vessels, has excellent diagnostic potential for early gastrointestinal epithelial neoplasia. Conventional diagnostic tools for uterine cervical epithelial tumors are still unsatisfactory. An accurate diagnostic tool for uterine cervical epithelial tumors is required to preserve the reproductive ability of young women with uterine cervical tumors. Flexible NBI-ME was performed in patients with cervical squamous cell lesions that required further examinations based on their Pap smear results (cytology ≥ low-grade squamous intraepithelial lesion) at Kagawa University Hospital between April 2014 and April 2015...
July 2017: Oncology Letters
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