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https://www.readbyqxmd.com/read/28325915/prognostic-value-of-ca20-a-score-based-on-centrosome-amplification-associated-genes-in-breast-tumors
#1
Angela Ogden, Padmashree C G Rida, Ritu Aneja
Centrosome amplification (CA) is a hallmark of cancer, observable in ≥75% of breast tumors. CA drives aggressive cellular phenotypes such as chromosomal instability (CIN) and invasiveness. Thus, assessment of CA may offer insights into the prognosis of breast cancer and identify patients who might benefit from centrosome declustering agents. However, it remains unclear whether CA is correlated with clinical outcomes after adjusting for confounding factors. To gain insights, we developed a signature, "CA20", comprising centrosome structural genes and genes whose dysregulation is implicated in inducing CA...
March 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28325903/whole-genome-analysis-of-human-papillomavirus-types-16-18-and-58-isolated-from-cervical-precancer-and-cancer-samples-in-chinese-women
#2
Ying Liu, Yaqi Pan, Weijiao Gao, Yang Ke, Zheming Lu
Human papillomavirus (HPV) types 16, 18 and 58 are ranked the top three high-risk HPV types for cervical intraepithelial neoplasia (CIN) and invasive carcinoma. We aimed to evaluate the diversity of HPV16, HPV18, and HPV58 genetic variants by HPV capture technology combined with next generation sequencing. 295, 73, and 148 variations were observed in 51 HPV16, 7 HPV18, and 11 HPV58 genomes, respectively. HPV16 isolates were predominantly of the A variant lineage, and sublineage A4 (Asian) was the most common...
March 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28324169/roles-of-centromedian-parafascicular-nuclei-of-thalamus-and-cholinergic-interneurons-in-the-dorsal-striatum-in-associative-learning-of-environmental-events
#3
REVIEW
Ko Yamanaka, Yukiko Hori, Takafumi Minamimoto, Hiroshi Yamada, Naoyuki Matsumoto, Kazuki Enomoto, Toshihiko Aosaki, Ann M Graybiel, Minoru Kimura
The thalamus provides a massive input to the striatum, but despite accumulating evidence, the functions of this system remain unclear. It is known, however, that the centromedian (CM) and parafascicular (Pf) nuclei of the thalamus can strongly influence particular striatal neuron subtypes, notably including the cholinergic interneurons of the striatum (CINs), key regulators of striatal function. Here, we highlight the thalamostriatal system through the CM-Pf to striatal CINs. We consider how, by virtue of the direct synaptic connections of the CM and PF, their neural activity contributes to the activity of CINs and striatal projection neurons (SPNs)...
March 21, 2017: Journal of Neural Transmission
https://www.readbyqxmd.com/read/28320994/a-nomogram-to-predict-contrast-induced-nephropathy-in-patients-undergoing-percutaneous-coronary-intervention
#4
Xun Hu, Xiao-Dong Zhuang, Yi Li, Fei-Fei Li, Yue Guo, Zhi-Min Du, Xin-Xue Liao
Contrast-induced nephropathy (CIN) is the third leading cause of hospital-acquired acute kidney injury (AKI). Emerging evidence has revealed that soluble klotho (sklotho) could be a novel biomarker for early AKI diagnosis. The aims of this study were to assess the predictive role of sklotho for CIN and to develop a prediction nomogram in patients undergoing percutaneous coronary intervention (PCI). This study is registered on Clinicaltrials.gov (NCT 02650336).Patients aged 18 years or older undergoing planned PCI were prospectively recruited between May 2014 and July 2015...
March 21, 2017: International Heart Journal
https://www.readbyqxmd.com/read/28320991/pre-procedural-risk-score-of-contrast-induced-nephropathy-in-elderly-patients-undergoing-elective-coronary-angiography
#5
Dan Lian, Yong Liu, Yuan-Hui Liu, Hua-Long Li, Chong-Yang Duan, Dan-Qing Yu
To establish a scoring model to predict the risk of contrast-induced nephropathy (CIN) in elderly patients undergoing elective coronary angiography (CAG).A total of 1286 patients aged > 65 years who had undergone elective CAG between August 2009 and February 2013 were enrolled in this study. They were randomly (3:2) assigned to a development (n = 756) or validation dataset (n = 530). Independent predictors of CIN were identified by using logistic regression and were assigned a weighted integer, which was used to establish a score model...
March 21, 2017: International Heart Journal
https://www.readbyqxmd.com/read/28319578/podoplanin-and-sox2-expression-in-cin-3-like-squamous-cell-carcinoma-of-the-cervix
#6
Colin J R Stewart, Maxine L Crook
Squamous cell carcinoma (SCC) of the uterine cervix occasionally demonstrates a deceptive growth pattern that mimics endocervical crypt involvement by cervical intraepithelial neoplasia, grade 3 (CIN 3). Such CIN 3-like SCCs may be misinterpreted as noninvasive or minimally invasive leading to delays in diagnosis. Little is known of the factors that influence the growth patterns of cervical SCC but we suggested recently that CIN 3-like tumors might demonstrate "collective cellular invasion," which is characterized by a retained epithelial phenotype...
March 17, 2017: International Journal of Gynecological Pathology
https://www.readbyqxmd.com/read/28318489/deletion-of-the-mad2l1-spindle-assembly-checkpoint-gene-is-tolerated-in-mouse-models-of-acute-t-cell-lymphoma-and-hepatocellular-carcinoma
#7
Floris Foijer, Lee A Albacker, Bjorn Bakker, Diana C Spierings, Ying Yue, Stephanie Z Xie, Stephanie H Davis, Annegret Lutum-Jehle, Darin Takemoto, Brian Hare, Brinley Furey, Roderick T Bronson, Peter M Lansdorp, Allan Bradley, Peter K Sorger
Chromosome instability (CIN) is deleterious to normal cells because of the burden of aneuploidy. However, most human solid tumors have an abnormal karyotype implying that gain and loss of chromosomes by cancer cells confers a selective advantage. CIN can be induced in the mouse by inactivating the spindle assembly checkpoint. This is lethal in the germline but we show here that adult T cells and hepatocytes can survive conditional inactivation of the Mad2l1 SAC gene and resulting CIN. This causes rapid onset of acute lymphoblastic leukemia (T-ALL) and progressive development of hepatocellular carcinoma (HCC), both lethal diseases...
March 20, 2017: ELife
https://www.readbyqxmd.com/read/28304400/evaluation-of-p16-ki-67-dual-stained-cytology-as-triage-test-for-high-risk-human-papillomavirus-positive-women
#8
Renée Mf Ebisch, Judith van der Horst, Meyke Hermsen, L Lucia Rijstenberg, Judith Em Vedder, Johan Bulten, Remko P Bosgraaf, Viola Mj Verhoef, Daniëlle Am Heideman, Peter Jf Snijders, Chris Jlm Meijer, Folkert J van Kemenade, Leon Fag Massuger, Willem Jg Melchers, Ruud Lm Bekkers, Albert G Siebers
The aim of this study was to evaluate the clinical utility of p16/Ki-67 dual staining, for the identification of CIN in high-risk HPV-positive women from a non-responder screening cohort. P16/Ki-67 dual staining, Pap cytology, and HPV16/18 genotyping were performed on physician-taken liquid-based samples from 495 women who tested high-risk HPV positive on self-sampled material (PROHTECT-3B study). Different triage strategies involving p16/Ki-67 dual staining were evaluated for sensitivity, specificity, and predictive value for ≥CIN2 and ≥CIN3, and compared to Pap cytology with a threshold of atypical cells of undetermined significance...
March 17, 2017: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/28303645/zero-contrast-percutaneous-coronary-intervention-on-calcified-lesions-facilitated-by-rotational-atherectomy
#9
Keyvan Karimi Galougahi, Gary S Mintz, Dimitri Karmpaliotis, Ziad A Ali
Percutaneous coronary intervention (PCI) in patients with advanced chronic kidney disease (CKD) is challenging due to frequent presence of complex calcified lesions and the very high risk of contrast-induced nephropathy (CIN). We report a strategy of "zero contrast" PCI, guided by intravascular imaging and physiology, performed in three patients with advanced CKD in whom severe calcification necessitated rotational atherectomy (RA) to facilitate and optimize PCI. This approach resulted in safe and successful PCI while preserving renal function...
March 17, 2017: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/28299002/impression-cytology-in-a-series-of-clinically-diagnosed-ocular-surface-melanocytic-lesions
#10
Mozhgan Rezaei Kanavi, Seyed Bagher Hosseini, Roshanak Aliakbar-Navahi, Hossein Aghaei
PURPOSE: To report impression cytology (IC) results of clinically diagnosed ocular surface melanocytic lesions. METHODS: Ten patients with a clinical diagnosis of an ocular surface melanocytic lesion underwent IC using cellulose acetate strips and Periodic acid Schiff-Papanicolaou staining. Excisional biopsy of lesions was performed in case of observing atypical cells on IC or at the patient's request, and excised specimens were subjected to histopathological analysis...
January 2017: Journal of Ophthalmic & Vision Research
https://www.readbyqxmd.com/read/28288134/dub3-and-usp7-de-ubiquitinating-enzymes-control-replication-inhibitor-geminin-molecular-characterization-and-associations-with-breast-cancer
#11
S Hernández-Pérez, E Cabrera, E Salido, M Lim, L Reid, S R Lakhani, K K Khanna, J M Saunus, R Freire
Correct control of DNA replication is crucial to maintain genomic stability in dividing cells. Inappropriate re-licensing of replicated origins is associated with chromosomal instability (CIN), a hallmark of cancer progression that at the same time provides potential opportunities for therapeutic intervention. Geminin is a critical inhibitor of the DNA replication licensing factor Cdt1. To properly achieve its functions, Geminin levels are tightly regulated through the cell cycle by ubiquitin-dependent proteasomal degradation, but the de-ubiquitinating enzymes (DUBs) involved had not been identified...
March 13, 2017: Oncogene
https://www.readbyqxmd.com/read/28285845/a-stratified-randomized-double-blind-phase-ii-trial-of-celecoxib-for-treating-patients-with-cervical-intraepithelial-neoplasia-the-potential-predictive-value-of-vegf-serum-levels-an-nrg-oncology-gynecologic-oncology-group-study
#12
Janet S Rader, Michael W Sill, Jan H Beumer, Heather A Lankes, Doris Mangiaracina Benbrook, Francisco Garcia, Connie Trimble, J Tate Thigpen, Richard Lieberman, Rosemary E Zuna, Charles A Leath, Nick M Spirtos, John Byron, Premal H Thaker, Shashikant Lele, David Alberts
PURPOSE: To examine the effect of celecoxib on cervical intraepithelial neoplasia 3 (CIN 3). This is a NRG Oncology/Gynecologic Oncology Group study with translational biomarkers. PATIENTS AND METHODS: Patients with CIN 3 were randomized to celecoxib 400mg once daily (67 patients) or placebo (63 patients) for 14-18weeks. The primary outcome measure was histologic regression. A test of equal probabilities of success between two therapies was conducted, using Fisher's Exact Test at alpha=10% and 90% power when the treatment arm boosted the probability of success by 30%...
March 9, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/28283546/functional-association-of-oestrogen-receptors-with-hpv-infection-in-cervical-carcinogenesis
#13
REVIEW
Balaji Ramachandran
Repeated parity and usage of oral contraceptives have demonstrated an increased risk of cervical cancer (CC) in HPV-infected women. These lifestyle observations raise the likelihood that oestrogens and HPV infection might act synergistically to affect cancers of the cervix. In vivo studies have indicated the requirement of oestrogens and ERα in the development of atypical squamous metaplasia followed by cervical intraepithelial neoplasia (CIN) I, II and III. CIN II and III are precancerous cervical lesions that can progress over time to CC as an invasive carcinoma...
April 2017: Endocrine-related Cancer
https://www.readbyqxmd.com/read/28281738/efficacy-of-nicorandil-treatment-for-prevention-of-contrast-induced-nephropathy-in-high-risk-patients-undergoing-cardiac-catheterization-a-prospective-randomized-controlled-trial
#14
Leili Iranirad, Seyed Fakhreddin Hejazi, Mohammad Saleh Sadeghi, Shahram Arsang Jang
BACKGROUND: Contrast-induced nephropathy (CIN) remains to be a potentially serious complication of radiographic procedures and is the third leading cause of the acute kidney injury (AKI) among hospitalized patients. This clinical trial was performed to assess the preventive effect of oral nicorandil on CIN in high-risk patients undergoing cardiac catheterization. METHODS: In this prospective, randomized, controlled trial, 128 patients with at least two risk factors for CIN undergoing elective percutaneous coronary intervention (PCI) were randomly assigned to either the nicorandil group or the control group...
March 10, 2017: Cardiology Journal
https://www.readbyqxmd.com/read/28274319/-highly-expressed-sulfiredoxin-and-%C3%AE-catenin-are-associated-with-malignancy-of-cervical-squamous-cell-carcinoma
#15
Kangyun Lan, Xiaoyan Chen, Qin Liu, Yue Fan, Yuni Zhao, Hui Wang
Objective To investigate the expressions of sulfiredoxin (Srx) and β-catenin in human cervical squamous cell carcinoma (CSCC) and their clinical significance. Methods Immunohistochemistry was used to detect the expressions of Srx and β-catenin in human cervical specimens, including normal cervical squamous cell epithelium tissues (NC), cervical intraepithelial neoplasia tissues (CIN), and CSCC. The correlation between Srx expression and β-catenin expression and the relationship of the two proteins to clinical the pathological features of cervical cancer were analyzed...
March 2017: Xi Bao Yu Fen Zi Mian Yi Xue za Zhi, Chinese Journal of Cellular and Molecular Immunology
https://www.readbyqxmd.com/read/28264203/underdiagnosis-of-cervical-intraepithelial-neoplasia-cin-2-or-worse-lesion-in-women-with-a-previous-colposcopy-guided-biopsy-showing-cin-1
#16
Carlos André Scheler de Souza, Michelle Garcia Discacciati, Maria Gabriela d'Otavianno, Silvia Maria Bergo, Markus Traue, Liliana Aparecida Lucci de Angelo Andrade, Luiz Carlos Zeferino
Objective Expectant follow-up for biopsy-proven cervical intraepithelial neoplasia (CIN) 1 is the current recommendation for the management of this lesion. Nevertheless, the performance of the biopsy guided by colposcopy might not be optimal. Therefore, this study aimed to calculate the rate of underdiagnoses of more severe lesions in women with CIN 1 diagnosis and to evaluate whether age, lesion extent and biopsy site are factors associated with diagnostic failure. Methods Eighty women with a diagnosis of CIN 1 obtained by colposcopy-guided biopsy were selected for this study...
March 6, 2017: Revista Brasileira de Ginecologia e Obstetrícia
https://www.readbyqxmd.com/read/28260365/-ultrastructural-alteration-of-extraocular-muscle-proprioceptor-in-congenital-idiopathic-nystagmus
#17
C Y Zhang, D Y Bai, Y H Cui, S L Hu, Y Zhang, C Li, L Li
Objective: To explore the ultrastructural alteration of extraocular muscle proprioceptor in congenital idiopathic nystagmus (CIN). Methods: Case-control study. Ten extraocular muscle samples were collected from five CIN children who underwent nystagmus surgeries in Beijing Children's Hospital from March 2015 to March 2016. Another ten extraocular muscle specimens were collected from five strabismus children in surgery at the same period as normal contrast. There were 3 male patients and 2 female patients of CIN with age of 61-147 months (median age: 91 months)...
February 11, 2017: [Zhonghua Yan Ke za Zhi] Chinese Journal of Ophthalmology
https://www.readbyqxmd.com/read/28260085/roles-of-immune-inhibitory-molecule-b7-h4-in-cervical-cancer
#18
Sai Han, Yi Li, Jingjing Zhang, Lu Liu, Qian Chen, Qiuhong Qian, Shan Li, Youzhong Zhang
Recent studies have reported that the immune-regulatory protein B7-H4 is highly expressed in various types of cancer, but little is known concerning its roles in cervical cancer. In the present study, we investigated the expression of B7-H4 in human tissues and serum samples, and explored the effects of B7-H4 on proliferation, apoptosis, migration and invasion of cervical cancer cell lines, including SiHa and HeLa. We found that B7-H4 was mainly located in the cytoplasm of cervical cancer cells as determined by immunofluorescence staining...
March 1, 2017: Oncology Reports
https://www.readbyqxmd.com/read/28260077/atorvastatin-protects-against-contrast-induced-nephropathy-via-anti-apoptosis-by-the-upregulation-of-hsp27-in%C3%A2-vivo-and-in%C3%A2-vitro
#19
Xuyu He, Junqing Yang, Liwen Li, Hong Tan, Ying Wu, Peng Ran, Shuo Sun, Jiyan Chen, Yingling Zhou
Contrast-induced nephropathy (CIN) is an iatrogenic acute renal failure occurring following the intravascular injection of iodinated radiographic contrast medium. However, the regulatory mechanisms for CIN remain to be fully elucidated. The present study aimed to investigate whether atorvastatin protects against CIN via anti‑apoptotic effects by the upregulation of Hsp27 in vivo and in vitro. To determine whether atorvastatin attenuated CIN, the inflammatory response and apoptosis in vivo and in vitro, a rat model of iopamidol‑induced CIN was used, and human embryonic proximal tubule (HK2) cell damage was assessed...
February 28, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28257290/human-papillomavirus-co-testing-results-effectively-triage-normal-cervical-cytology-in-hiv-positive-women-aged-30-years-and-older
#20
Rachel O Alade, Olivera Vragovic, Conor Duffy, Howard J Cabral, Elizabeth A Stier
OBJECTIVE: The aim of the study was to assess whether HIV-positive (HIV+) women aged 30 years and older with concurrent normal cervical cytology and undetectable cervical HPV have a low 3-year risk of developing cervical intraepithelial neoplasia grade 2 or higher (CIN 2+) in a clinical setting. MATERIALS AND METHODS: We conducted a retrospective chart review of HIV+ women aged 30 years and older at a single institution with normal cervical cytology and concurrent human papillomavirus (HPV) testing between November 2008 and December 2010...
March 2, 2017: Journal of Lower Genital Tract Disease
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