keyword
MENU ▼
Read by QxMD icon Read
search

CIN

keyword
https://www.readbyqxmd.com/read/28644191/yield-of-cytology-surveillance-after-high-grade-vulvar-intraepithelial-neoplasia-or-cancer
#1
Lindsay M Kuroki, Antonina I Frolova, Ningying Wu, Jingxia Liu, Matthew Powell, Premal H Thaker, L Stewart Massad
OBJECTIVES: The aim of the study was to estimate the risk of high-grade cervical and vaginal intraepithelial neoplasia (CIN/VAIN 2+) and cancer among women treated surgically for high-grade vulvar intraepithelial neoplasia (HGVIN) and vulvar cancer. MATERIALS AND METHODS: We performed a retrospective cohort study of women who underwent surgery for HGVIN/vulvar cancer between 2006 and 2010. Univariate and multivariate analyses using stepwise selection were used to identify correlates of abnormal cytology after treatment for VIN and vulvar cancer...
July 2017: Journal of Lower Genital Tract Disease
https://www.readbyqxmd.com/read/28643661/impact-of-anaesthesia-mode-on-evaluation-of-leep-specimen-dimensions
#2
A Mercuzot, J Chevreau, H Sevestre, C Muszynski, M Arbyn, F Sergent, J Gondry
OBJECTIVES: To study the influence of anaesthesia (local by cervical block vs. general or spinal anaesthesia) on height and volume of resection specimens in case of conization treatment for cervical intraepithelial neoplasia (CIN). METHODS: Prospective observational study of all patients who underwent a first treatment by loop electrosurgical excision procedure (LEEP) for CIN. Height of fresh resection specimens was first measured by the operator and then by the pathologist after formaldehyde fixation...
April 2017: Journal of gynecology obstetrics and human reproduction
https://www.readbyqxmd.com/read/28642116/contrast-induced-nephropathy-basic-concepts-pathophysiological-implications-and-prevention-strategies
#3
REVIEW
Charalampos Mamoulakis, Konstantinos Tsarouhas, Irini Fragkiadoulaki, Ioannis Heretis, Martin F Wilks, Demetrios A Spandidos, Christina Tsitsimpikou, Aristides Tsatsakis
Contrast-induced nephropathy (CIN) is reversible acute renal failure observed following administration of iodinated contrast media (CM) during angiographic or other medical procedures such as urography. There are various mechanisms through which CM develop their nephrotoxic effects, including oxidative stress and apoptosis. CIN is a real-life, albeit not very rare, entity. Exact pathophysiology remains obscure and no standard diagnostic criteria apply. The Acute Kidney Injury Network criteria was recently employed but its incidence/clinical significance warrants further clarification based on recent methodological advancements, because most published studies to date were contaminated by bias...
June 19, 2017: Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/28632949/potential-impact-of-nonavalent-hpv-vaccine-in-the-prevention-of-high-grade-cervical-lesions-and-cervical-cancer-in-portugal
#4
Angela Pista, Carlos Freire de Oliveira, Carlos Lopes, Maria J Cunha
OBJECTIVE: To estimate the potential impact of the nonavalent HPV vaccine for high-grade cervical lesions and invasive cervical cancer (ICC) in Portugal. METHODS: The present secondary analysis used data collected in the CLEOPATRE II study on the prevalence of HPV 6/11/16/18/31/33/45/52/58 among female patients aged 20-88 years. The prevalence of HPV types in patients with cervical intraepithelial neoplasia (CIN) grades 2/3 and ICC was examined. RESULTS: Data were included from 582 patients...
June 20, 2017: International Journal of Gynaecology and Obstetrics
https://www.readbyqxmd.com/read/28628608/tcp4-dependent-induction-of-constans-transcription-requires-gigantea-in-photoperiodic-flowering-in-arabidopsis
#5
Akane Kubota, Shogo Ito, Jae Sung Shim, Richard S Johnson, Yong Hun Song, Ghislain Breton, Greg S Goralogia, Michael S Kwon, Dianne Laboy Cintrón, Tomotsugu Koyama, Masaru Ohme-Takagi, Jose L Pruneda-Paz, Steve A Kay, Michael J MacCoss, Takato Imaizumi
Photoperiod is one of the most reliable environmental cues for plants to regulate flowering timing. In Arabidopsis thaliana, CONSTANS (CO) transcription factor plays a central role in regulating photoperiodic flowering. In contrast to posttranslational regulation of CO protein, still little was known about CO transcriptional regulation. Here we show that the CINCINNATA (CIN) clade of class II TEOSINTE BRANCHED 1/ CYCLOIDEA/ PROLIFERATING CELL NUCLEAR ANTIGEN FACTOR (TCP) proteins act as CO activators. Our yeast one-hybrid analysis revealed that class II CIN-TCPs, including TCP4, bind to the CO promoter...
June 19, 2017: PLoS Genetics
https://www.readbyqxmd.com/read/28628197/vesicular-acetylcholine-transporter-vacht-overexpression-induces-major-modifications-of-striatal-cholinergic-interneuron-morphology-and-function
#6
Helena Janickova, Vania F Prado, Marco A M Prado, Salah El Mestikawy, Véronique Bernard
Striatal cholinergic interneurons (CIN) are pivotal for the regulation of the striatal network. Acetylcholine (ACh) released by CIN is centrally involved in reward behavior as well as locomotor or cognitive functions. Recently, BAC transgenic mice expressing channelrhodopsin-2 (ChR2) protein under the control of the choline acetyltransferase (ChAT) promoter (ChAT-ChR2) and displaying almost 50 extra copies of the VAChT gene were used to dissect cholinergic circuit connectivity and function using optogenetic approaches...
June 19, 2017: Journal of Neurochemistry
https://www.readbyqxmd.com/read/28624259/body-talk-weight-status-and-pathological-eating-behavior-in-romantic-relationships
#7
Ellen Hart, Chong Man Chow, Cin Cin Tan
This study examined whether engagement in body talk would interact with weight status (body mass index; BMI) to predict pathological eating behaviors among romantically involved adults. Adults (N = 137, females = 86.86%, average age = 23.50) involved in a romantic relationship were recruited to complete an online survey about their body image, dietary behaviors, and engagement in body talk. Results indicated that engagement in negative body talk was directly related to higher pathological eating (i.e...
June 14, 2017: Appetite
https://www.readbyqxmd.com/read/28620555/a-discussion-of-high-risk-hpv-in-a-6-year-old-female-survivor-of-child-sexual-abuse
#8
Connie D Cao, Lena Merjanian, Joelle Pierre, Adrian Balica
BACKGROUND: Human papilloma viruses (HPVs) cause a variety of clinical manifestations in children including skin warts, laryngeal papillomas, and condyloma acuminatum. Whereas the mode of transmission is well understood and management of HPV infection is clearly defined by guidelines in adults, less is known about the mode of transmission, natural history of disease, and appropriate management of high-risk anogenital HPV infections in children. CASE: The patient is a previously healthy 6-year-old female who presented with multiple vaginal lesions causing pain and discomfort and was diagnosed with HPV 18 positive CIN I...
2017: Case Reports in Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28616457/cervical-cancer-screening-at-a-tertiary-care-center-in-rwanda
#9
George Ruzigana, Lisa Bazzet-Matabele, Stephen Rulisa, Allison N Martin, Rahel G Ghebre
In limited resource settings such as Rwanda, visual inspection with acetic acid (VIA) is the primary model for cervical cancer screening. The objective of this study was to describe clinical characteristics and outcomes for women presenting for cervical cancer screening. A prospective, observational study was conducted between September 2015 and February 2016 at Kigali University Teaching Hospital (CHUK). Women referred to the VIA clinic were enrolled and completed a semi-structured questionnaire. During the six-month study period, 150 women were enrolled and evaluated with VIA followed by colposcopy directed biopsy for VIA positive...
August 2017: Gynecologic Oncology Reports
https://www.readbyqxmd.com/read/28612708/contribution-of-matrix-metalloproteinases-1-genotypes-to-gastric-cancer-susceptibility-in-taiwan
#10
Mei-Due Yang, Kuo-Cheng Lin, Meng-Chun Lu, Long-Bin Jeng, Chieh-Lun Hsiao, Te-Cheng Yueh, Chun-Kai Fu, Hsin-Ting Li, Shiou-Ting Yen, Chia-Wen Lin, Cin-Wun Wu, Su-Yi Pang, Da-Tian Bau, Fuu-Jen Tsai
Expression of matrix metalloproteinase-1 (MMP1), an interstitial collagenase regulating the extracellular matrix, plays a major role in carcinogenesis of gastric cancer, a leading cause of death worldwide. In literature, the single-nucleotide polymorphism (SNP) promoter -1607 1G/2G (rs1799750) at the MMP1 gene promoter has been reported to alter its own transcription level. While the importance's of the genotype of MMP1 promoter -1607 has not yet been studied in gastric cancer in Taiwan, our aim was to investigate MMP1 promoter -1607 genotypes and gastric cancer (GC) susceptibility in central Taiwan population...
June 2017: BioMedicine
https://www.readbyqxmd.com/read/28608311/potential-role-of-allopurinol-in-preventing-contrast-induced-nephropathy-in-patients-undergoing-percutaneous-coronary-intervention-a-randomized-placebo-controlled-trial
#11
Zahra Ghelich Khan, Azita Hajhossein Talasaz, Hamidreza Pourhosseini, Kianoush Hosseini, Mohammad Javad Alemzadeh Ansari, Arash Jalali
BACKGROUND: Contrast-induced nephropathy (CIN) is a major drawback in percutaneous coronary intervention (PCI). Significant uricosuria has been reported following contrast exposure. Allopurinol-a xanthine oxidase inhibitor-has been suggested to prevent the formation of oxygen-free radicals, which may contribute to CIN. The aim of the present study was to evaluate the possible efficacy of allopurinol in preventing CIN. METHODS: In this double-blind placebo-controlled trial, patients with an estimated glomerular filtration rate ≥60 mL/min who were admitted for elective PCI, were randomized to receive either allopurinol 600 mg or a placebo administered 24 h before the procedure, and again immediately before the procedure...
June 12, 2017: Clinical Drug Investigation
https://www.readbyqxmd.com/read/28607602/cervical-cancers-manifest-a-high-rate-of-infection-by-a-high-risk-human-papilloma-virus-subtype-but-a-very-low-rate-of-infection-by-a-low-risk-subtype-in-the-guiyang-district-of-china
#12
Juan Peng, Yan Yuan, Feng Shen, Yan Wang, Lichan Chen, D Joshua Liao, Yujie Tan
The prevalence of infection by different genotypes of human papillomavirus (HPV) varies among different geographic areas. We studied the prevalence of infection by 21 HPV genotypes in cervical tissue specimens from 4213 women in the Guiyang district, that is located in the southwest of China and is dominated by minor ethnicities of Chinese, and 2074 cases in our cohort had pathological diagnosis available. The overall infection rate was 36.98%. Most (72.08%) infectors were positive for only one HPV subtype, with the remaining being cases infected by two or more subtypes...
2017: Journal of Cancer
https://www.readbyqxmd.com/read/28605926/cystatin-c-but-not-urinary-or-serum-ngal-may-be-associated-with-contrast-induced-nephropathy-after-percutaneous-coronary-invasive-procedures-a-single-center-experience-on-a-limited-number-of-patients
#13
Emanuele Cecchi, Gianfranco Avveduto, Maria Grazia D'Alfonso, Alessandro Terreni, Emma Gelera, Anna Caldini, Cristina Giglioli
OBJECTIVE: This study aimed to test the association of both the baseline values and post-procedural variations of urinary and serum Neutrophil Gelatinase-Associated Lipocalin (NGAL) and Cystatin C (CysC) with contrast induced nephropathy (CIN) occurrence in patients undergoing percutaneous coronary invasive procedures (PCIP), and compare them to serum creatinine and the estimated glomerular filtration rate (eGFR). METHODS: In 43 patients admitted to our Cardiac Step-Down Unit and submitted to PCIP, we measured serum creatinine and eGFR as the standard markers for CIN diagnosis, and compared them to both serum and urinary NGAL as well as serum CysC, assessed before and 4 hours after PCIP...
May 2017: Acta Medica Academica
https://www.readbyqxmd.com/read/28603715/contrast-induced-nephropathy-in-renal-transplant-recipients-a-single-center-experience
#14
Bassam G Abu Jawdeh, Anthony C Leonard, Yuvraj Sharma, Swapna Katipally, Adele R Shields, Rita R Alloway, E Steve Woodle, Charuhas V Thakar
BACKGROUND: Contrast-induced nephropathy (CIN) in native kidneys is associated with a significant increase in mortality and morbidity. Data regarding CIN in renal allografts are limited, however. We retrospectively studied CIN in renal allografts at our institution: its incidence, risk factors, and effect on long-term outcomes including allograft loss and death. METHODS: One hundred thirty-five renal transplant recipients undergoing 161 contrast-enhanced computed tomography (CT) scans or coronary angiograms (Cath) between years 2000 and 2014 were identified...
2017: Frontiers in Medicine
https://www.readbyqxmd.com/read/28603453/centromeric-non-coding-transcription-opening-the-black-box-of-chromosomal-instability
#15
REVIEW
Rodrigo Cáceres-Gutiérrez, Luis A Herrera
In eukaryotes, mitosis is tightly regulated to avoid the generation of numerical chromosome aberrations, or aneuploidies. The aneuploid phenotype is a consequence of chromosomal instability (CIN), i.e., an enhanced rate of chromosome segregation errors, which is frequently found in cancer cells and is associated with tumor aggressiveness and increased tumor cell survival potential. To avoid the generation of aneuploidies, cells rely on the spindle assembly checkpoint (SAC), a widely conserved mechanism that protects the genome against this type of error...
June 2017: Current Genomics
https://www.readbyqxmd.com/read/28603034/relaxation-induced-by-the-nitric-oxide-donor-and-cyclooxygenase-inhibitor-ncx2121-in-renal-hypertensive-rat-aortas
#16
Tiago Dal-Cin de Paula, Bruno R Silva, Marcella D Grando, Laena Pernomian, Alejandro Ferraz do Prado, Lusiane Maria Bendhack
No abstract text is available yet for this article.
June 8, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28600294/cervical-intraepithelial-neoplasia-cin-in-african-women-living-with-hiv-role-and-effect-of-rigorous-histopathological-review-by-a-panel-of-pathologists-in-the-harp-study-endpoint-determination
#17
Sylviane Doutre, Tanvier Omar, Olga Goumbri-Lompo, Helen Kelly, Omar Clavero, Souleymane Zan, Admire Chikandiwa, Bernard Sawadogo, Sinead Delany-Moretlwe, Valérie Costes, Philippe Mayaud, Michel Segondy
AIMS: To analyse the effect of the expert end-point committee (EPC) review on histological endpoint classification of cervical intraepithelial neoplasia (CIN). METHODS: A cohort of women living with HIV were recruited in Burkina Faso (BF) and South Africa (SA) and followed over 18 months. Four-quadrant cervical biopsies were obtained in women with abnormalities detected by at least one screening test. A central review by a panel of five pathologists was organised at baseline and at endline...
June 9, 2017: Journal of Clinical Pathology
https://www.readbyqxmd.com/read/28599442/promoter-methylation-status-of-the-tumor-suppressor-genes-p16-and-cadherin-1-in-cervical-intraepithelial-neoplasia
#18
Ruei-Nian Li, Chien-Yu Li, Chien-Hung Lee, Chiung-Yu Peng, Ming-Tsang Wu
Cervical cancer is the second most common female cancer worldwide. DNA methylation is one of a number of epigenetic regulation mechanisms leading to gene silencing in neoplastic cells. Aberrant methylation results in the silencing of tumor suppressor gene expression, and has been detected in a high percentage of human cancers. In the present study, the methylation status of three tumor suppressor genes, retinoic acid receptor β (RARβ), p16 and cadherin 1 (CDH1), and the inflammatory-associated cyclooxygenase-2 (COX-2) gene, was examined at distinct stages of cervical intraepithelial neoplasia (CIN)...
June 2017: Oncology Letters
https://www.readbyqxmd.com/read/28598108/-hpv-e7-function-in-dna-damage-response-of-cervical-intraepithelial-neoplasia
#19
Han-Yu Cao, Xiao-Jun Wang, Zi-Zhi Tang, Jiang-Yan Lou
OBJECTIVES: To determine the function of human papillomavirus (HPV) E7 in DNA damage response of cervical intraepithelial neoplasia (CIN) 3 cells. METHODS: Samples of CIN 3 and child foreskin tissues were collected,with pathologically confirmed HPV positive and negative,respectively.Collagenase A was used for digesting tissues prior to primary culture.The HPV negative cells were infected with lentivirus E7 and pLV.Proteins(53BP1,NBS1,BRCA1 and RPA32) responsive to DNA double break damages were detected by indirect immunofluorescent staining after 0-8 h treatment with X-ray (2 or 5 Gy)...
November 2016: Sichuan da Xue Xue Bao. Yi Xue Ban, Journal of Sichuan University. Medical Science Edition
https://www.readbyqxmd.com/read/28596481/mislocalization-of-centromeric-histone-h3-variant-cenp-a-contributes-to-chromosomal-instability-cin-in-human-cells
#20
Roshan L Shrestha, Grace S Ahn, Mae I Staples, Kizhakke M Sathyan, Tatiana S Karpova, Daniel R Foltz, Munira A Basrai
Chromosomal instability (CIN) is a hallmark of many cancers and a major contributor to tumorigenesis. Centromere and kinetochore associated proteins such as the evolutionarily conserved centromeric histone H3 variant CENP-A, associate with centromeric DNA for centromere function and chromosomal stability. Stringent regulation of cellular CENP-A levels prevents its mislocalization in yeast and flies to maintain genome stability. CENP-A overexpression and mislocalization are observed in several cancers and reported to be associated with increased invasiveness and poor prognosis...
May 23, 2017: Oncotarget
keyword
keyword
26221
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"