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https://www.readbyqxmd.com/read/28747559/breast-cancer-suppression-by-aplysin-is-associated-with-inhibition-of-pi3k-akt-foxo3a-pathway
#1
Xinling Zhang, Tingting Zhuang, Zhengyan Liang, Li Li, Meilan Xue, Jia Liu, Hui Liang
Aplysin, a bromosesquiterpene isolated from Aplysia kurodai, was explored as a potential anti-breast cancer agent by us. However, the mechanisms underlying the anticarcinogenic effect of aplysin remain unclear. Here, aplysin was found to remarkably suppress tumor growth in vivo, inhibit cell proliferation and promote apoptosis in vitro. Additionally, we demonstrated that aplysin attained these effects in part by down-regulating PI3K/AKT/FOXO3a signaling pathway. Aplysin treatment inhibited the phosphorylation levels of AKT (Ser-473) and AKT-dependent phosphorylation of FOXO3a (Ser-253) in breast cancer cell lines and breast cancer tissues...
July 12, 2017: Oncotarget
https://www.readbyqxmd.com/read/28745798/research-on-apoptotic-signaling-pathways-of-recurrent-spontaneous-abortion-caused-by-dysfunction-of-trophoblast-infiltration
#2
Q Sun, X-L Zhang
OBJECTIVE: To study the apoptotic signaling pathways of recurrent spontaneous abortion caused by dysfunction of trophoblast infiltration. PATIENTS AND METHODS: 60 patients with recurrent spontaneous abortion and normal abortion were selected consecutively as recurrent spontaneous abortion group and abortion group, respectively. Villous tissues were obtained and cell apoptosis was observed under a microscope; terminal deoxynucleotidyl transferase (TdT)-mediated dUTP nick end labeling (Tunel) method was used to test the apoptosis rate...
July 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28736380/-association-of-fasl-844t-c-gene-polymorphism-with-fasl-expression-in-the-nucleus-pulposus-of-degenerative-lumbar-intervertebral-discs
#3
Zheng-Ming Sun, Pengmaojiacuo Pengmaojiacuo, Hong-Hai Xu, Yan-Hai Chang, Xue-Yuan Wu, Xiang-Hui Dong, Ming Ling
OBJECTIVE: To investigate the association of FasL-844T/C gene polymorphism with the magnetic resonance imaging (MRI) findings and FasL expression in the nucleus pulposus of degenerative lumbar intervertebral discs. METHODS: Lumbar MRI data, venous blood and nucleus pulposus were collected from 105 patients with lumbar disc herniation. The genotypes of FasL-844T/C gene of the patients were determined using matrix-assisted laser desorption ionization time-of-flight mass spectrometry...
July 20, 2017: Nan Fang Yi Ke da Xue Xue Bao, Journal of Southern Medical University
https://www.readbyqxmd.com/read/28734673/somatostatin-protects-human-retinal-pericytes-from-inflammation-mediated-by-microglia
#4
Aurora Mazzeo, Ana I Arroba, Elena Beltramo, Angela M Valverde, Massimo Porta
Diabetic retinopathy (DR) is usually considered a microvascular disease. However, involvement of the neuroretina in the early stages of DR has recently gained major credit. Inflammatory processes, leading to glial activation and neuronal apoptosis, develop early in the retina of diabetic subjects. Pericytes constitute a link between the vascular and the neural retina, play a central role in blood-retinal barrier maintenance, and may influence neuroinflammation. Somatostatin (SST) is a potent neuroprotective factor, which is down-regulated during early DR...
July 19, 2017: Experimental Eye Research
https://www.readbyqxmd.com/read/28732794/glutamine-protects-intestinal-calcium-absorption-against-oxidative-stress-and-apoptosis
#5
Luciana Moine, Gabriela Díaz de Barboza, Adriana Pérez, Mercedes Benedetto, Nori Tolosa de Talamoni
The aim of this study was to investigate whether glutamine (GLN) could block the inhibition of the intestinal Ca(2+) absorption caused by menadione (MEN), and elucidate the underlying mechanisms. To do this, one-month old chicks were divided in four groups: 1) controls, 2) MEN treated, 3) GLN treated and 4) GLN treated before or after MEN treatment. Intestinal Ca(2+) absorption as well as protein expression of molecules involved in the transcellular Ca(2+) pathway were determined. Glutathione (GSH) and superoxide anion and activity of enzymes of the antioxidant system were evaluated...
July 18, 2017: Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology
https://www.readbyqxmd.com/read/28722192/roles-of-fas-fasl-mediated-apoptosis-and-inhibin-b-in-the-testicular-dysfunction-of-rats-with-left-side-varicocele
#6
J Zhang, P P Jin, M Gong, J H Guo, K Fang, Q T Yi, R J Zhu
We investigated the role of the Fas/FasL signalling pathway and inhibin B expression in rats with an experimentally induced left-side varicocele. Forty-five Sprague Dawley (SD) male rats were randomly divided into three groups in average: control group, sham group and experimental group. The expression of inhibin B in the rat left testis was analysed at the mRNA and protein levels by reverse transcription-polymerase chain reaction (RT-PCR) and Western blotting respectively. The expressions of Fas, FasL and caspase-3 in the left testis were measured by RT-PCR and immunofluorescence...
July 18, 2017: Andrologia
https://www.readbyqxmd.com/read/28717228/transformation-of-patchouli-alcohol-to-%C3%AE-patchoulene-by-gastric-juice-%C3%AE-patchoulene-is-more-effective-in-preventing-ethanol-induced-gastric-injury
#7
Yuhong Liu, Jiali Liang, Jiazhen Wu, Hanbin Chen, Zhenbiao Zhang, Hongmei Yang, Liping Chen, Haiming Chen, Ziren Su, Yucui Li
Pogostemonis Herba is a functional food approved in Asian countries. Its major constituent, patchouli alcohol (PA), possesses a gastroprotective effect and is reported to transform into β-patchoulene (β-PAE) under acidic conditions. To investigate whether β-PAE, the metabolite of PA, has a protective effect on the gastrointestinal tract, the formation of β-PAE by gastric juice and the anti-ulcerogenic potential of β-PAE against ethanol-induced gastric injury were evaluated. The Results indicated that PA was converted to β-PAE by rat gastric juice...
July 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28701864/induction-of-forkhead-class-box-o3a-and-apoptosis-by-a-standardized-ginsenoside-formulation-kg-135-is-potentiated-by-autophagy-blockade-in-a549-human-lung-cancer-cells
#8
Chih-Jung Yao, Jyh-Ming Chow, Shuang-En Chuang, Chia-Lun Chang, Ming-De Yan, Hsin-Lun Lee, I-Chun Lai, Pei-Chun Lin, Gi-Ming Lai
BACKGROUND: KG-135, a standardized formulation enriched with Rk1, Rg3, and Rg5 ginsenosides, has been shown to inhibit various types of cancer cells; however, the underlying mechanisms are not fully understood. In this study, we explored its effects in A549 human lung cancer cells to investigate the induction of Forkhead Class box O3a (FOXO3a) and autophagy. METHODS: Cell viability was determined by sulforhodamine B staining. Apoptosis and cell cycle distribution were analyzed using flow cytometry...
July 2017: Journal of Ginseng Research
https://www.readbyqxmd.com/read/28701757/oncolytic-measles-virus-enhances-antitumour-responses-of-adoptive-cd8-nkg2d-cells-in-hepatocellular-carcinoma-treatment
#9
Aiping Chen, Yonghui Zhang, Gang Meng, Dengxu Jiang, Hailin Zhang, Meihong Zheng, Mao Xia, Aiqin Jiang, Junhua Wu, Christian Beltinger, Jiwu Wei
There is an urgent need for novel effective treatment for hepatocellular carcinoma (HCC). Oncolytic viruses (OVs) not only directly lyse malignant cells, but also induce potent antitumour immune responses. The potency and precise mechanisms of antitumour immune activation by attenuated measles virus remain unclear. In this study, we investigated the potency of the measles virus vaccine strain Edmonston (MV-Edm) in improving adoptive CD8(+)NKG2D(+) cells for HCC treatment. We show that MV-Edm-infected HCC enhanced the antitumour activity of CD8(+)NKG2D(+) cells, mediated by at least three distinct mechanisms...
July 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28691411/kupffer-cell-in-the-immune-activation-and-tolerance-toward-hbv-hcv-infection
#10
REVIEW
Yuan Fangchao, Zhang Wenfeng, Mu Di, Gong Jianping
Kupffer cells(KCs) largely found in the sinusoids are the macrophages which specifically reside in liver. KC is a crucial part of innate immune system, acting as scavenger and phagocyte. KCs and sinusoidal endothelial cells together form the first immune barrier of the portal system. Studies show that KCs can not only maintain homeostasis in immune response, but also facilitate the pathogenesis of type B and type C hepatitis through their antigen-presenting function and secretion of soluble mediators. KCs can express TLRs (Toll-like receptors), FasL, Programmed cell death ligand 1 (PD-L1) and secrete large amount of inflammatory factors to lead to the tolerant state of immune response toward HBV/HCV...
June 27, 2017: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/28689916/molecular-mechanism-of-anti-cancerous-potential-of-morin-extracted-from-mulberry-in-hela-cells
#11
Qi Zhang, Fang Zhang, Kiran Thakur, Jun Wang, Hao Wang, Fei Hu, Jian-Guo Zhang, Zhao-Jun Wei
The flavonoids are of great interest due to their antioxidant and anti-cancerous potential. The present study investigated the Morin extracted from mulberry leaves and its anti-cancerous mechanism via cell inhibition, cell cycle analysis, apoptosis, mRNA expression and antioxidant mechanism through reactive oxygen species generation. Morin inhibited the proliferation of HeLa cells at IC50 of 214.28 μM and led to morphological changes, followed by induction of cell cycle arrest in G2/M-phase and ultimately resulted into apoptosis...
July 6, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/28689023/profiling-of-cytokines-chemokines-and-other-soluble-proteins-as-a-potential-biomarker-in-colorectal-cancer-and-polyps
#12
Nor Adzimah Johdi, Luqman Mazlan, Ismail Sagap, Rahman Jamal
Soluble proteins including cytokines, chemokines and growth factors are small proteins that mediate and regulate immunity. They involved in the pathogenesis of many diseases including cancers. The concentration of these proteins in biological fluids (serum or plasma) and tissues in diseases may suggest pathway activation that leads to inflammatory response or disease progression. Therefore, these soluble proteins may be useful as a tool for screening, diagnosis classification between stages of disease or surveillance for therapy...
July 6, 2017: Cytokine
https://www.readbyqxmd.com/read/28687593/effect-of-controlled-ovarian-hyperstimulation-on-puberty-and-estrus-in-mice-offspring
#13
Jiahui Ding, Xiujuan Tan, Kunkun Song, Wenwen Ma, Jing Xiao, Mingmin Zhang
Controlled ovarian hyperstimulation (COH) is widely used for the treatment of infertility, while the long-term effects of COH on the reproductive function in female offspring are currently unknown. Based on the fact that COH could cause high E2 levels in women throughout pregnancy, and excess estrogenic exposure during fetal development is harmful to subsequent adult ovarian function. We assumed the hypothesis that COH disrupts reproductive function in female offspring. To test this hypothesis, COH was induced in mice to obtain female offspring by PMSG and HCG, then we evaluated pubertal transition, serum levels of E2, AMH, FSH and LH, mRNA expressions of Esr1, Amhr2, Fshr and Lhcgr in ovaries, number of follicles and ovarian histology, and we also investigated apoptosis of follicles by TUNEL, the mRNA expressions of Fas, FasL, Bax, Bcl2, Caspase3, 8 and 9 by Quantitative Real-Time PCR, as well as the protein expressions of CLEAVED-CASPASE3, 8 and 9 by Western blot...
July 7, 2017: Reproduction: the Official Journal of the Society for the Study of Fertility
https://www.readbyqxmd.com/read/28687341/carbenoxolone-prevents-chemical-eye-ischemia-reperfusion-induced-cell-death-via-11%C3%AE-hydroxysteroid-dehydrogenase-type-1-inhibition
#14
Kyoung-Jin Choi, Yoon-Ju Na, Sung Bum Park, Won Hoon Jung, Hye-Rim Sung, Ki Young Kim
Glaucoma is one of the leading causes of preventable blindness diseases, affecting more than 2 million people in the United States. Recently, 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitors were found to exert preventive effects against glaucoma. Therefore, we investigated whether carbenoxolone (CBX), an 11β-HSD1 inhibitor, prevents chemical ischemia-reperfusion-induced cell death in human trabecular meshwork (HTM) cells. The present study demonstrated that CBX inhibited cell death caused by iodoacetic acid (IAA)-induced ischemia-reperfusion, and its effect was associated with the inhibition of 11β-HSD1 expression and activity...
July 4, 2017: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/28686330/gstp1-c-313a-g-xpd-c-934g-a-xpf-c-2505t-c-and-casp9-c-1339a-g-polymorphisms-and-severity-of-vomiting-in-head-and-neck-cancer-patients-treated-with-cisplatin-chemoradiation
#15
Juliana Carron, Leisa Lopes-Aguiar, Ericka Francislaine Dias Costa, Guilherme Augusto Silva Nogueira, Tathiane Regine Penna Lima, Eder Carvalho Pincinato, Marilia Berlofa Visacri, Júlia Coelho França Quintanilha, Patrícia Moriel, Gustavo Jacob Lourenço, Carmen Silvia Passos Lima
Cisplatin (CDDP) chemotherapy associated with radiation (RT) has been used in advanced head and neck squamous cell carcinoma (HNSCC) patients, and vomiting is a common side effect during treatment. This prospective study aimed to identify the roles of GSTM1 and GSTT1 (presents or nulls), GSTP1 c.313A>G, XPC c.2815A>C, XPD c.934G>A and c.2251A>C, XPF c.2505T>C, ERCC1 c.354C>T, MLH1 c.-93G>A, MSH2 c.211+9C>G, MSH3 c.3133G>A, EXO1 c.1765G>A, TP53 c.215G>C, CASP3 c.-1191A>G and c...
July 7, 2017: Basic & Clinical Pharmacology & Toxicology
https://www.readbyqxmd.com/read/28682425/fas-fasl-induces-myocardial-cell-apoptosis-in-myocardial-ischemia-reperfusion-rat-model
#16
X-M Liu, Z-M Yang, X-K Liu
OBJECTIVE: Myocardium ischemia reperfusion is easy to induce myocardial injury. Fas/FasL is an important signaling pathway mediating cell apoptosis. This study aims to analyze the cell apoptosis and Fas/FasL expression in myocardial cell ischemia reperfusion rat model. MATERIALS AND METHODS: Coronary artery ligation method was used to establish myocardial ischemia reperfusion model. Rats were grouped according to different ischemia and reperfusion time: Group A, myocardial ischemia for 30 min and reperfusion for 24 h; Group B, myocardial ischemia for 30 min and reperfusion for 48 h; Group C, myocardial ischemia for 1 h and reperfusion for 24 h...
June 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28665255/hypothermia-identifies-dynamin-as-a-potential-therapeutic-target-in-experimental-stroke
#17
Jong Youl Kim, Nuri Kim, Jong Eun Lee, Midori A Yenari
Apoptosis is a cell death pathway that is activated in ischemic stroke. The interaction between Fas and its ligand (FasL) initiates a complex pattern of intracellular events involving the recruitment of specific adaptor proteins and the development of apoptosis. We recently reported that dynamin is increased after experimental stroke, and its inhibition improves neurological outcome. Dynamin has been shown to transport Fas from the endoplasmic reticulum to the cell surface where it can be bound by its ligand, FasL...
June 30, 2017: Therapeutic Hypothermia and Temperature Management
https://www.readbyqxmd.com/read/28663674/fas-receptor-activation-by-endogenous-opioids-is-a-new-mechanism-for-cardiomyopathy-in-cirrhotic-rats
#18
Ata Abbasi, Negar Faramarzi, Mohsen Khosravi, Fatemeh Yazarloo, Mohammad Amin Abbasi, Ahmad R Dehpour, Issa Jahanzad
BACKGROUND: Cirrhosis, a common consequence of chronic liver inflammation is associated with various cardiovascular dysfunctions which are called cirrhotic cardiomyopathy (CC). Among the various possible causes of CC, apoptosis is considered to have a pivotal role. OBJECTIVES: To explore the contribution of endogenous opioids in the apoptosis process in a rat model of CC. MATERIAL AND METHODS: Four genes were selected to cover both intrinsic and extrinsic pathways of apoptosis...
June 2017: Journal of Clinical and Experimental Hepatology
https://www.readbyqxmd.com/read/28659495/ceramide-phosphoethanolamine-synthase-smsr-is-a-target-of-caspase-6-during-apoptotic-cell-death
#19
Birol Cabukusta, Niclas T Nettebrock, Matthijs Kol, Angelika Hilderink, Fikadu G Tafesse, Joost C M Holthuis
Ceramides are essential precursors of sphingolipids with a dual role as mediators of apoptotic cell death. Previous work revealed that the ER-resident ceramide phosphoethanolamine synthase SMSr/SAMD8 is a suppressor of ceramide-mediated apoptosis in cultured cells. Anti-apoptotic activity of SMSr requires a catalytically active enzyme but also relies on the enzyme's N -terminal sterile α-motif or SAM domain. Here we demonstrate that SMSr itself is a target of the apoptotic machinery. Treatment of cells with staurosporine or the death receptor ligand FasL triggers caspase-mediated cleavage of SMSr at a conserved aspartate located downstream of the enzyme's SAM domain and upstream of its first membrane span...
June 28, 2017: Bioscience Reports
https://www.readbyqxmd.com/read/28652014/anti-inflammatory-effect-of-man-pen-fang-a-chinese-herbal-compound-on-chronic-pelvic-inflammation-in-rats
#20
Li-Jun Zhang, Jian-Yong Zhu, Meng-Yao Sun, Ya-Nan Song, Khalid Rahman, Cheng Peng, Miao Zhang, Yu-Mei Ye, Hong Zhang
ETHNOPHARMACOLOGICAL RELEVANCE: Traditional Chinese Medicine (TCM) has become the focus of research for the treatment of chronic pelvic inflammatory disease (CPID) based on unique medical theory system. Man-Pen-Fang (MPF), a Chinese herbal compound, which is composed of Thlaspi arvense L. (Cruciferae), Gleditsia sinensis Lam. (Leguminosae), Smilax china L. (Liliaceae), Euonymus alatus (Thunb.) Sieb. (Celastraceae) and Vaccaria segetalis (Neck.) (Caryophyllaceae) MPF has been used for the treatment of CPID and exerted significant clinical curative effects...
June 23, 2017: Journal of Ethnopharmacology
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