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Chirag Patel

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https://www.readbyqxmd.com/read/29330552/dosimetry-prediction-for-clinical-translation-of-64cu-pembrolizumab-immunopet-targeting-human-pd-1-expression
#1
Arutselvan Natarajan, Chirag B Patel, Frezghi Habte, Sanjiv S Gambhir
The immune checkpoint programmed death 1 receptor (PD-1) expressed on some tumor-infiltrating lymphocytes, and its ligand (PD-L1) expressed on tumor cells, enable cancers to evade the immune system. Blocking PD-1 with the monoclonal antibody pembrolizumab is a promising immunotherapy strategy. Thus, noninvasively quantifying the presence of PD-1 expression in the tumor microenvironment prior to initiation of immune checkpoint blockade may identify the patients likely to respond to therapy. We have developed a 64Cu-pembrolizumab radiotracer and evaluated human dosimetry...
January 12, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29315504/physiologically-based-pharmacokinetic-model-qualification-and-reporting-procedures-for-regulatory-submissions-a-consortium-perspective
#2
REVIEW
Mohamad Shebley, Punam Sandhu, Arian Emami Riedmaier, Masoud Jamei, Rangaraj Narayanan, Aarti Patel, Sheila Annie Peters, Venkatesh Pilla Reddy, Ming Zheng, Loeckie de Zwart, Maud Beneton, Francois Bouzom, Jun Chen, Yuan Chen, Yumi Cleary, Christiane Collins, Gemma L Dickinson, Nassim Djebli, Heidi J Einolf, Iain Gardner, Felix Huth, Faraz Kazmi, Feras Khalil, Jing Lin, Aleksandrs Odinecs, Chirag Patel, Haojing Rong, Edgar Schuck, Pradeep Sharma, Shu-Pei Wu, Yang Xu, Shinji Yamazaki, Kenta Yoshida, Malcolm Rowland
No abstract text is available yet for this article.
January 9, 2018: Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/29311748/integrated-analysis-of-gene-expression-differences-in-twins-discordant-for-disease-and-binary-phenotypes
#3
Sivateja Tangirala, Chirag J Patel
While both genes and environment contribute to phenotype, deciphering environmental contributions to phenotype is a challenge. Furthermore, elucidating how different phenotypes may share similar environmental etiologies also is challenging. One way to identify environmental influences is through a discordant monozygotic (MZ) twin study design. Here, we assessed differential gene expression in MZ discordant twin pairs (affected vs. non-affected) for seven phenotypes, including chronic fatigue syndrome, obesity, ulcerative colitis, major depressive disorder, intermittent allergic rhinitis, physical activity, and intelligence quotient, comparing the spectrum of genes differentially expressed across seven phenotypes individually...
January 8, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29282402/acute-endophthalmitis-caused-by-leuconostoc-spp-following-intravitreal-bevacizumab-injection
#4
Supreet Singh, Chirag V Patel, Kamal Kishore
We present a case of acute endophthalmitis caused by Leuconostoc spp. following intravitreal bevacizumab injection. An 86-year-old immunocompetent female developed acute endophthalmitis after intravitreal injection of bevacizumab for neovascular age-related macular degeneration. The patient presented with pain, visual acuity of hand motions, hypopyon, and dense vitritis 96 h after treatment. She was treated with vitreous and anterior chamber tap followed by intravitreal injections of 1 mg vancomycin, 2.25 mg ceftazidime, and 400 μg dexamethasone...
September 2017: Case Reports in Ophthalmology
https://www.readbyqxmd.com/read/29281938/pharmacophore-based-virtual-screening-of-catechol-o-methyltransferase-comt-inhibitors-to-combat-alzheimer-s-disease
#5
Chirag N Patel, John J Georrge, Krunal M Modi, Moksha B Narechania, Daxesh P Patel, Frank J Gonzalez, Himanshu A Pandya
Alzheimer's disease (AD) is one of the most significant neurodegenerative disorders and its symptoms mostly appear in aged people. Catechol-o-methyltransferase (COMT) is one of the known target enzymes responsible for AD. With the use of 23 known inhibitors of COMT, a query has been generated and validated by screening against the database of 1500 decoys to obtain the GH score and enrichment value. The crucial features of the known inhibitors were evaluated by the online ZINC Pharmer to identify new leads from a ZINC database...
December 27, 2017: Journal of Biomolecular Structure & Dynamics
https://www.readbyqxmd.com/read/29228186/aether-leveraging-linear-programming-for-optimal-cloud-computing-in-genomics
#6
Jacob M Luber, Braden T Tierney, Evan M Cofer, Chirag J Patel, Aleksandar D Kostic
Motivation: Across biology we are seeing rapid developments in scale of data production without a corresponding increase in data analysis capabilities. Results: Here, we present Aether (http://aether.kosticlab.org), an intuitive, easy-to-use, cost-effective, and scalable framework that uses linear programming (LP) to optimally bid on and deploy combinations of underutilized cloud computing resources. Our approach simultaneously minimizes the cost of data analysis and provides an easy transition from users' existing HPC pipelines...
December 8, 2017: Bioinformatics
https://www.readbyqxmd.com/read/29222684/how-much-do-plastic-surgeons-add-to-the-closure-of-myelomeningoceles
#7
Rhian Bevan, Nicholas Wilson-Jones, Imran Bhatti, Chirag Patel, Paul Leach
PURPOSE: This study reviews the outcomes of children undergoing myelomeningocele (MMC) repair in the paediatric neurosurgical department in Cardiff. These procedures are historically performed by paediatric neurosurgeons with occasional support from plastic surgeons for the larger lesions. We reviewed the postoperative outcomes over a 9-year period to assess the efficacy of having a plastic surgeon present at all MMC closures. METHODS: Analysis of a prospectively collected database of all MMC closures performed at University Hospital Wales from April 2009 to August 2017 was used...
December 8, 2017: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://www.readbyqxmd.com/read/29221465/yale-school-of-public-health-symposium-on-lifetime-exposures-and-human-health-the-exposome-summary-and-future-reflections
#8
REVIEW
Caroline H Johnson, Toby J Athersuch, Gwen W Collman, Suraj Dhungana, David F Grant, Dean P Jones, Chirag J Patel, Vasilis Vasiliou
The exposome is defined as "the totality of environmental exposures encountered from birth to death" and was developed to address the need for comprehensive environmental exposure assessment to better understand disease etiology. Due to the complexity of the exposome, significant efforts have been made to develop technologies for longitudinal, internal and external exposure monitoring, and bioinformatics to integrate and analyze datasets generated. Our objectives were to bring together leaders in the field of exposomics, at a recent Symposium on "Lifetime Exposures and Human Health: The Exposome," held at Yale School of Public Health...
December 8, 2017: Human Genomics
https://www.readbyqxmd.com/read/29197281/trends-in-peri-operative-performance-status-following-resection-of-high-grade-glioma-and-brain-metastases-the-impact-on-survival
#9
Chirag K Patel, Ravi Vemaraju, James Glasbey, Joanne Shires, Tessa Northmore, Malik Zaben, Caroline Hayhurst
OBJECTIVES: Maximal surgical resection of high grade brain tumours is associated with improved overall survival (OS). It carries the risk of neurological deterioration leading to worsening performance status (PS), which may affect overall survival and preclude patients from adjuvant therapy. We aim to review the changes in performance status of patients undergoing resection of high grade tumours and metastases and the impact of changes on overall survival. PATIENTS AND METHODS: A prospective study of the perioperative performance status of 75 patients who underwent primary resection of malignant primary brain tumour or solitary metastasis in a single centre...
December 1, 2017: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/29162757/low-fidelity-simulation-to-enhance-understanding-of-infection-control-among-undergraduate-medical-students
#10
Suman P Singh, Chirag M Modi, Chirag P Patel, Ajay G Pathak
BACKGROUND: Developing economies are stressing institutional care for better health outcomes but its advantages are dampened by healthcare-associated infections (HAIs). Besides other undesired complications, the economic cost of HAIs is enormous. Developing countries have higher HAI rates compared with Europe or the USA. The knowledge and practice of infection control is poor among medical students. Based on introspection of 'Infection Control Module' for undergraduates introduced in 2012, we tested emotional sensitization using low-fidelity techniques to enhance its effectiveness...
July 2017: National Medical Journal of India
https://www.readbyqxmd.com/read/29153890/molecular-dynamics-assisted-pharmacophore-modeling-of-caspase-3-isatin-sulfonamide-complex-recognizing-essential-intermolecular-contacts-and-features-of-sulfonamide-inhibitor-class-for-caspase-3-binding
#11
Sivakumar Prasanth Kumar, Chirag N Patel, Prakash C Jha, Himanshu A Pandya
The identification of isatin sulfonamide as a potent small molecule inhibitor of caspase-3 had fuelled the synthesis and characterization of the numerous sulfonamide class of inhibitors to optimize for potency. Recent works that relied on the ligand-based approaches have successfully shown the regions of optimizations for sulfonamide scaffold. We present here molecular dynamics-based pharmacophore modeling of caspase-3-isatin sulfonamide crystal structure, to elucidate the essential non-covalent contacts and its associated pharmacophore features necessary to ensure caspase-3 optimal binding...
August 9, 2017: Computational Biology and Chemistry
https://www.readbyqxmd.com/read/29119349/southern-california-neuroinvasive-west-nile-virus-case-series
#12
Chirag B Patel, Bhavesh V Trikamji, Glenn E Mathisen, Shrikant K Mishra
Approximately 80% of individuals infected with West Nile virus (WNV) are asymptomatic, and less than 1% suffer from neuroinvasion that can result in permanent neurological deficits or mortality. Our institution's location in southern California predisposes it to a sizable case volume of neuroinvasive WNV. A 2-year retrospective study was performed at the Olive View-UCLA Medical Center to identify patients with confirmed WNV infection with neuroinvasion. Patient demographics, neurological exam findings, and laboratory diagnostics were reviewed...
November 8, 2017: Neurological Sciences
https://www.readbyqxmd.com/read/29088959/traumatic-brain-injury-and-intracranial-hemorrhage-induced-cerebral-vasospasm-a-systematic-review
#13
Fawaz Al-Mufti, Krishna Amuluru, Abhinav Changa, Megan Lander, Neil Patel, Ethan Wajswol, Sarmad Al-Marsoummi, Basim Alzubaidi, I Paul Singh, Rolla Nuoman, Chirag Gandhi
OBJECTIVE Little is known regarding the natural history of posttraumatic vasospasm. The authors review the pathophysiology of posttraumatic vasospasm (PTV), its associated risk factors, the efficacy of the technologies used to detect PTV, and the management/treatment options available today. METHODS The authors performed a systematic review in accordance with the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines using the following databases: PubMed, Google Scholar, and CENTRAL (the Cochrane Central Register of Controlled Trials)...
November 2017: Neurosurgical Focus
https://www.readbyqxmd.com/read/29074088/the-american-brachytherapy-society-consensus-statement-for-accelerated-partial-breast-irradiation
#14
Chirag Shah, Frank Vicini, Simona F Shaitelman, Jaroslaw Hepel, Martin Keisch, Douglas Arthur, Atif J Khan, Robert Kuske, Rakesh Patel, David E Wazer
PURPOSE: Adjuvant radiation after breast-conserving surgery remains the standard-of-care treatment for patients with ductal carcinoma in situ and early-stage invasive breast cancer. Multiple alternatives to standard whole-breast irradiation exist including accelerated partial-breast irradiation (APBI). Therefore, the purpose of this APBI guideline is to provide updated data for clinicians as well as recommendations regarding appropriate patient selection and techniques to deliver APBI...
October 23, 2017: Brachytherapy
https://www.readbyqxmd.com/read/29066231/antibiotic-prophylaxis-and-infection-prevention-for-endoscopic-endonasal-skull-base-surgery-our-protocol-results-and-review-of-the-literature
#15
Stephen J Johans, Daniel J Burkett, Kevin N Swong, Chirag R Patel, Anand V Germanwala
Endoscopic endonasal approaches to the skull base provide minimally invasive corridors to intracranial lesions; however, enthusiasm for this new approach is always tempered by the recognition that this route requires passage through a nonsterile sinonasal corridor. Despite an increasing number of patients undergoing these surgeries, there remains no consensus on the use of perioperative antibiotics. A retrospective review of consecutive patients undergoing endoscopic endonasal skull base surgery (EESBS) at Loyola University Medical Center by the same neurosurgeon and otolaryngologist team between February 2015 and October 2016 was performed...
October 21, 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/29053078/contralateral-transmaxillary-corridor-an-augmented-endoscopic-approach-to-the-petrous-apex
#16
Chirag R Patel, Eric W Wang, Juan C Fernandez-Miranda, Paul A Gardner, Carl H Snyderman
OBJECTIVE The endoscopic endonasal approach (EEA) has been shown to be an effective means of accessing lesions of the petrous apex. Lesions that are lateral to the paraclival segment of the internal carotid artery (ICA) require lateralization of the paraclival segment of the ICA or a transpterygoid infrapetrous approach. In this study the authors studied the feasibility of adding a contralateral transmaxillary (CTM) corridor to provide greater access to the petrous apex with decreased need for manipulation of the ICA...
October 20, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/29038595/covariate-selection-for-association-screening-in-multiphenotype-genetic-studies
#17
Hugues Aschard, Vincent Guillemot, Bjarni Vilhjalmsson, Chirag J Patel, David Skurnik, Chun J Ye, Brian Wolpin, Peter Kraft, Noah Zaitlen
Testing for associations in big data faces the problem of multiple comparisons, wherein true signals are difficult to detect on the background of all associations queried. This difficulty is particularly salient in human genetic association studies, in which phenotypic variation is often driven by numerous variants of small effect. The current strategy to improve power to identify these weak associations consists of applying standard marginal statistical approaches and increasing study sample sizes. Although successful, this approach does not leverage the environmental and genetic factors shared among the multiple phenotypes collected in contemporary cohorts...
October 16, 2017: Nature Genetics
https://www.readbyqxmd.com/read/28978193/current-challenges-and-new-opportunities-for-gene-environment-interaction-studies-of-complex-diseases
#18
Kimberly McAllister, Leah E Mechanic, Christopher Amos, Hugues Aschard, Ian A Blair, Nilanjan Chatterjee, David Conti, W James Gauderman, Li Hsu, Carolyn M Hutter, Marta M Jankowska, Jacqueline Kerr, Peter Kraft, Stephen B Montgomery, Bhramar Mukherjee, George J Papanicolaou, Chirag J Patel, Marylyn D Ritchie, Beate R Ritz, Duncan C Thomas, Peng Wei, John S Witte
Recently, many new approaches, study designs, and statistical and analytical methods have emerged for studying gene-environment interactions (G×Es) in large-scale studies of human populations. There are opportunities in this field, particularly with respect to the incorporation of -omics and next-generation sequencing data and continual improvement in measures of environmental exposures implicated in complex disease outcomes. In a workshop called "Current Challenges and New Opportunities for Gene-Environment Interaction Studies of Complex Diseases," held October 17-18, 2014, by the National Institute of Environmental Health Sciences and the National Cancer Institute in conjunction with the annual American Society of Human Genetics meeting, participants explored new approaches and tools that have been developed in recent years for G×E discovery...
October 1, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/28978192/update-on-the-state-of-the-science-for-analytical-methods-for-gene-environment-interactions
#19
W James Gauderman, Bhramar Mukherjee, Hugues Aschard, Li Hsu, Juan Pablo Lewinger, Chirag J Patel, John S Witte, Christopher Amos, Caroline G Tai, David Conti, Dara G Torgerson, Seunggeun Lee, Nilanjan Chatterjee
The analysis of gene-environment interaction (G×E) may hold the key for further understanding the etiology of many complex traits. The current availability of high-volume genetic data, the wide range in types of environmental data that can be measured, and the formation of consortiums of multiple studies provide new opportunities to identify G×E but also new analytical challenges. In this article, we summarize several statistical approaches that can be used to test for G×E in a genome-wide association study...
October 1, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/28977198/anterior-minithoracotomy-a-safe-approach-for-surgical-asd-closure-asd-device-retrieval
#20
Vivek Wadhawa, Chirag Doshi, Manish Hinduja, Pankaj Garg, Kartik Patel, Amit Mishra, Pratik Shah
OBJECTIVE: Midline sternotomy is the preferred approach for device migration following transcatheter device closure of ostium secundum atrial septal defect. Results of patients operated for device migration were retrospectively reviewed after transcatheter closure of atrial septal defect. METHODS: Among the 643 patients who underwent atrial septal defect with closure device, 15 (2.3%) patients were referred for device retrieval and surgical closure of atrial septal defect...
July 2017: Brazilian Journal of Cardiovascular Surgery
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