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Chirag Patel

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https://www.readbyqxmd.com/read/27903014/effects-of-meteorological-variables-on-the-incidence-of-rupture-of-intracranial-aneurysms-in-central-new-jersey
#1
Marissa Kellogg, Dimitriy Petrov, Nitin Agarwal, Nitesh V Patel, David Richard Hansberry, Prateek Agarwal, Michael Brimacombe, Chirag D Gandhi, Charles Prestigiacomo
Introduction Previous studies have suggested relationships between the rupture of intracranial aneurysms and meteorological variables such as season, barometric pressure, and temperature. Our objective was to examine the relationship between the incidence of hospital admissions secondary to aneurysmal subarachnoid hemorrhage (aSAH) and meteorological variables in central New Jersey. Methods The study population consisted of 312 patients who presented to University Hospital in Newark, New Jersey, between January 1, 2003, and December 31, 2008, with aSAH...
November 30, 2016: Journal of Neurological Surgery. Part A, Central European Neurosurgery
https://www.readbyqxmd.com/read/27900230/giant-cell-tumour-of-proximal-phalanx-of-ring-finger-case-report-and-review-of-literature
#2
Rishit Soni, Chirag Kapoor, Malkesh Shah, Amit Patel, Paresh Golwala
Giant cell tumour (GCT) of bone arising from a phalanx of a finger is extremely rare. Only two percent of all reported GCTs are found in the hand, which show a higher rate of recurrence as compared to those occurring at a more proximal location. Here we report a rare case of giant cell tumour of proximal phalanx of the ring finger in a 20-year-old male, which was treated with extended curettage and bone grafting. After two years of follow-up, the patient was asymptomatic with complete functional recovery and no signs of recurrence...
October 18, 2016: Curēus
https://www.readbyqxmd.com/read/27896967/methods-to-ensure-the-reproducibility-of-biomedical-research
#3
Konrad J Karczewski, Nicholas P Tatonetti, Arjun K Manrai, Chirag J Patel, C Titus Brown, John P A Ioannidis
Science is not done in a vacuum - across fields of biomedicine, scientists have built on previous research and used data published in previous papers. A mainstay of scientific inquiry is the publication of one's research and recognition for this work is given in the form of citations and notoriety - ideally given in proportion to the quality of the work. Academic incentives, however, may encourage individual researchers to prioritize career ambitions over scientific truth. Recently, the New England Journal of Medicine published a commentary calling scientists who repurpose data "research parasites" who misuse data generated by others to demonstrate alternative hypotheses...
2016: Pacific Symposium on Biocomputing
https://www.readbyqxmd.com/read/27893593/trends-in-selected-measures-of-racial-and-ethnic-disparities-in-gonorrhea-and-syphilis-in-the-united-states-1981-2013
#4
Harrell W Chesson, Chirag G Patel, Thomas L Gift, Sevgi O Aral
BACKGROUND: The purpose of this study was to examine selected measures of racial and ethnic disparities in the reported incidence of syphilis and gonorrhea from 1981 to 2013 in the United States. METHODS: For each year, from 1981 to 2013, we calculated values for 5 disparity measures (Gini coefficient, 2 versions of the index of disparity, population attributable proportion, and the black-to-white rate ratio) for 5 racial/ethnic categories (non-Hispanic white, non-Hispanic black, Hispanic, American Indian/Alaska Native, and Asian/Pacific Islander)...
November 2016: Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/27881429/a-review-of-validation-strategies-for-computational-drug-repositioning
#5
Adam S Brown, Chirag J Patel
Repositioning of previously approved drugs is a promising methodology because it reduces the cost and duration of the drug development pipeline and reduces the likelihood of unforeseen adverse events. Computational repositioning is especially appealing because of the ability to rapidly screen candidates in silico and to reduce the number of possible repositioning candidates. What is unclear, however, is how useful such methods are in producing clinically efficacious repositioning hypotheses. Furthermore, there is no agreement in the field over the proper way to perform validation of in silico predictions, and in fact no systematic review of repositioning validation methodologies...
November 22, 2016: Briefings in Bioinformatics
https://www.readbyqxmd.com/read/27867238/comment-addressing-the-need-for-portability-in-big-data-model-building-and-calibration
#6
Chirag J Patel, Francesca Dominici
No abstract text is available yet for this article.
2016: Journal of the American Statistical Association
https://www.readbyqxmd.com/read/27862397/multiple-calcifying-pseudoneoplasms-of-the-neuraxis-mcapnon-distinct-entity-capnon-variant-or-old-neurocysticercosis
#7
Maram Abdaljaleel, Rajarshi Mazumder, Chirag B Patel, Kyuseok Im, Whitney Pope, Linda M Liau, Harry V Vinters, William H Yong
We report a case of multiple calcifying pseudoneoplasms of the neuraxis (MCAPNON) with associated multifocal perivascular microcalcifications and vascular calcinosis. Calcifying pseudoneoplasm of the neuraxis (CAPNON) is a very rare condition that may arise in extra-axial and occasionally, in intra-axial locations. Moreover, it is nearly always a solitary mass with only one case with two lesions reported. While the etiology and pathogenesis of CAPNON remains unclear, the histopathology findings of this entity have been well described...
November 10, 2016: Neuropathology: Official Journal of the Japanese Society of Neuropathology
https://www.readbyqxmd.com/read/27842954/a-three-dimensional-approach-for-quantifying-resultant-loading-at-the-knee
#8
Ryan T Lewinson, Chad P Maag, Victor M Y Lun, J Preston Wiley, Chirag Patel, Darren J Stefanyshyn
BACKGROUND: Clinical effectiveness of lateral wedges for knee osteoarthritis is inconsistent across studies. One explanation is that knee loading is not fully described by the peak frontal-plane knee moment. The purpose of this study was to propose a 3D resultant approach to describing moments at the knee and evaluate how this moment changes in response to lateral wedges. METHODS: Walking gait analysis was performed on 20 individuals with knee osteoarthritis, in their own shoes, with and without a six millimeter lateral wedge insole...
November 11, 2016: Knee
https://www.readbyqxmd.com/read/27837427/microwave-assisted-zrsio2-catalysed-synthesis-characterization-and-computational-study-of-novel-spiro-indole-thiazolidines-derivatives-as-anti-tubercular-agents
#9
Mayuri A Borad, Manoj N Bhoi, Sanjay K Rathwa, Mahesh S Vasava, Hitesh D Patel, Chirag N Patel, Himanshu A Pandya, Edwin A Pithawala, John J Georrge
In the current investigation, we prepared a series of novel spiro[indole-thiazolidines] derivatives (5a-5h) from 5-substituted isatin derivatives and thioglycolic acid (TGA) with ZrSiO2 as an efficient catalyst under microwave irradiation. The significant merits of this protocol have some significant merits such as simplicity in operation, simple, efficient workup, good practical yields of product and the employment of recyclable catalyst. All the new synthesized scaffold has been well characterized by various spectroscopic methods and elemental analysis...
November 11, 2016: Interdisciplinary Sciences, Computational Life Sciences
https://www.readbyqxmd.com/read/27807671/surgical-treatment-of-long-standing-overt-ventriculomegaly-in-adults-lova
#10
Ronak Ved, Paul Leach, Chirag Patel
BACKGROUND: Longstanding overt ventriculomegaly in adults (LOVA) is characterised by chronic hydrocephalus presumed to begin during infancy, but arresting before becoming clinically detectable. Later in life clinical features of hydrocephalus ensue, typically in the 5th or 6th decades. Only a relatively small number of LOVA case series have been published, and ambiguity remains regarding optimal management. This case series describes a series of patients with LOVA treated successfully at a single neurosurgical institution using endoscopic third ventriculostomy (ETV)...
November 2, 2016: Acta Neurochirurgica
https://www.readbyqxmd.com/read/27793791/natural-language-processing-enabled-and-conventional-data-capture-methods-for-input-to-electronic-health-records-a-comparative-usability-study
#11
David R Kaufman, Barbara Sheehan, Peter Stetson, Ashish R Bhatt, Adele I Field, Chirag Patel, James Mark Maisel
BACKGROUND: The process of documentation in electronic health records (EHRs) is known to be time consuming, inefficient, and cumbersome. The use of dictation coupled with manual transcription has become an increasingly common practice. In recent years, natural language processing (NLP)-enabled data capture has become a viable alternative for data entry. It enables the clinician to maintain control of the process and potentially reduce the documentation burden. The question remains how this NLP-enabled workflow will impact EHR usability and whether it can meet the structured data and other EHR requirements while enhancing the user's experience...
October 28, 2016: JMIR Medical Informatics
https://www.readbyqxmd.com/read/27789830/warburg-meets-epigenetics
#12
Chirag H Patel, Jonathan D Powell
No abstract text is available yet for this article.
October 28, 2016: Science
https://www.readbyqxmd.com/read/27779619/a-database-of-human-exposomes-and-phenomes-from-the-us-national-health-and-nutrition-examination-survey
#13
Chirag J Patel, Nam Pho, Michael McDuffie, Jeremy Easton-Marks, Cartik Kothari, Isaac S Kohane, Paul Avillach
The National Health and Nutrition Examination Survey (NHANES) is a population survey implemented by the Centers for Disease Control and Prevention (CDC) to monitor the health of the United States whose data is publicly available in hundreds of files. This Data Descriptor describes a single unified and universally accessible data file, merging across 255 separate files and stitching data across 4 surveys, encompassing 41,474 individuals and 1,191 variables. The variables consist of phenotype and environmental exposure information on each individual, specifically (1) demographic information, physical exam results (e...
October 25, 2016: Scientific Data
https://www.readbyqxmd.com/read/27779587/the-renin-inhibitor-aliskiren-protects-rat-lungs-from-the-histopathological-effects-of-fat-embolism
#14
Amanda N Fletcher, Agostino Molteni, Rakesh Ponnapureddy, Chirag Patel, Mark Pluym, Alan M Poisner
BACKGROUND: Fat embolism (FE) and the consequent fat embolism syndrome (FES) occurring after trauma or surgery can lead to serious pulmonary injury, including ARDS and death. Current treatment of FES is limited to supportive therapy. We have shown in a rat model that the renin angiotensin system (RAS) plays a significant role in the pathophysiology of FE since drugs interfering with the RAS, captopril and losartan, reduce the histopathologic pulmonary damage. The purpose of the current study was to determine if inhibition of renin by aliskiren, an FDA-approved drug for treating hypertension, would produce effective protection in the same model...
October 25, 2016: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/27777043/trends-in-hospitalization-and-mortality-of-venous-thromboembolism-in-hospitalized-patients-with-colon-cancer-and-their-outcomes-us-perspective
#15
Kalpit Devani, Nirav Patil, Carlos Roberto Simons-Linares, Nilay Patel, Palashkumar Jaiswal, Pranav Patel, Samir Patel, Chirag Savani, Kamlesh Sajnani, Mark Young, Chakradhar Reddy
INTRODUCTION: Venous thromboembolism (VTE) is a major cause of morbidity and mortality in hospitalized patients with colon cancer. We assessed nationwide population-based trends in rates of hospitalization and mortality from VTE among patients with colon cancer to determine its impact. METHODS: We queried the Nationwide Inpatient Sample (NIS) database entries from 2003 to 2011 to identify patients with colon cancer. Bivariate group comparisons between hospitalized patients with colon cancer with VTE to those without VTE were made...
September 20, 2016: Clinical Colorectal Cancer
https://www.readbyqxmd.com/read/27738729/efficacy-of-qualitative-response-assessment-interpretation-criteria-at-18f-fdg-pet-ct-for-predicting-outcome-in-locally-advanced-cervical-carcinoma-treated-with-chemoradiotherapy
#16
Andrew Scarsbrook, Sriram Vaidyanathan, Fahmid Chowdhury, Sarah Swift, Rachel Cooper, Chirag Patel
OBJECTIVES: To evaluate the utility of a standardized qualitative scoring system for treatment response assessment at 18F-FDG PET-CT in patients undergoing chemoradiotherapy for locally advanced cervical carcinoma and correlate this with subsequent patient outcome. METHODS: Ninety-six consecutive patients with locally advanced cervical carcinoma treated with radical chemoradiotherapy (CRT) in a single centre between 2011 and 2014 underwent 18F-FDG PET-CT approximately 3 months post-treatment...
October 14, 2016: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/27678460/meshdd-literature-based-drug-drug-similarity-for-drug-repositioning
#17
Adam S Brown, Chirag J Patel
OBJECTIVE: Drug repositioning is a promising methodology for reducing the cost and duration of the drug discovery pipeline. We sought to develop a computational repositioning method leveraging annotations in the literature, such as Medical Subject Heading (MeSH) terms. METHODS: We developed software to determine significantly co-occurring drug-MeSH term pairs and a method to estimate pair-wise literature-derived distances between drugs. RESULTS: We found that literature-based drug-drug similarities predicted the number of shared indications across drug-drug pairs...
September 27, 2016: Journal of the American Medical Informatics Association: JAMIA
https://www.readbyqxmd.com/read/27673001/poster-244-an-unusual-cause-of-coma-from-consumption-of-red-yeast-rice-a-case-report
#18
Yogen Patel, Alex B Behar, Chirag D Shah, Ravi E Kasi
No abstract text is available yet for this article.
September 2016: PM & R: the Journal of Injury, Function, and Rehabilitation
https://www.readbyqxmd.com/read/27635964/congress-of-neurological-surgeons-systematic-review-and-evidence-based-guideline-on-posttreatment-follow-up-evaluation-of-patients-with-nonfunctioning-pituitary-adenomas
#19
Mateo Ziu, Ian F Dunn, Christopher Hess, Maria Fleseriu, Mary E Bodach, Luis M Tumialan, Nelson M Oyesiku, Kunal S Patel, Renzhi Wang, Bob S Carter, James Y Chen, Clark C Chen, Chirag G Patil, Zachary Litvack, Gabriel Zada, Manish K Aghi
BACKGROUND: Nonfunctioning pituitary adenomas (NFPAs) are the most frequent pituitary tumors. Due to the lack of hormonal hypersecretion, posttreatment follow-up evaluation of NFPAs is challenging. OBJECTIVE: To create evidence-based guidelines in an attempt to formulate guidance for posttreatment follow-up in a consistent, rigorous, and cost-effective way. METHODS: An extensive literature search was performed. Only clinical articles describing postoperative follow-up of adult patients with NFPAs were included...
October 2016: Neurosurgery
https://www.readbyqxmd.com/read/27635958/congress-of-neurological-surgeons-systematic-review-and-evidence-based-guideline-on-preoperative-imaging-assessment-of-patients-with-suspected-nonfunctioning-pituitary-adenomas
#20
Clark C Chen, Bob S Carter, Renzhi Wang, Kunal S Patel, Christopher Hess, Mary E Bodach, Luis M Tumialan, Nelson M Oyesiku, Chirag G Patil, Zachary Litvack, Gabriel Zada, Manish K Aghi
BACKGROUND: The authors reviewed published articles pertaining to the preoperative imaging evaluation of nonfunctioning pituitary adenomas (NFPAs) and formulated recommendations. OBJECTIVE: To provide an exhaustive review of published articles pertaining to the preoperative imaging evaluation of nonfunctioning pituitary adenomas. METHODS: The MEDLINE database was queried for studies investigating imaging for the preoperative evaluation of pituitary adenomas...
October 2016: Neurosurgery
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