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Chirag Patel

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https://www.readbyqxmd.com/read/28194614/the-exposome-research-paradigm-an-opportunity-to-understand-the-environmental-basis-for-human-health-and-disease
#1
REVIEW
Germaine M Buck Louis, Melissa M Smarr, Chirag J Patel
PURPOSE OF REVIEW: This paper presents an overview of the exposome research paradigm with particular application to understanding human reproduction and development and its implications for health across a lifespan. RECENT FINDINGS: The exposome research paradigm has generated considerable discussion about its feasibility and utility for delineating the impact of environmental exposures on human health. Early initiatives are underway, including smaller proof-of-principle studies and larger concerted efforts...
February 13, 2017: Current Environmental Health Reports
https://www.readbyqxmd.com/read/28176476/recurrent-atypical-haemolytic-uraemic-syndrome-post-kidney-transplant-due-to-a-cd46-mutation-in-the-setting-of-smarcal1-mediated-inherited-kidney-disease
#2
REVIEW
Samuel Chan, Andrew J Mallett, Chirag Patel, Ross S Francis, David W Johnson, David W Mudge, Nicole M Isbel
Disorders in the regulation of the alternate complement pathway often result in complement-mediated damage to the microvascular endothelium and can be associated with both glomerulonephritis and atypical haemolytic uraemic syndrome. Inherited defects in complement regulatory genes or autoantibodies against complement regulatory proteins are predictive of the severity of the disease and the risk of recurrence post kidney transplantation. Heterozygous mutations in CD46, which codes for a transmembrane cofactor glycoprotein membrane cofactor protein, usually have a lower incidence of end-stage kidney disease and decreased risk of recurrent disease post transplant, as wild-type membrane cofactor protein is present in the transplanted kidney...
February 2017: Nephrology
https://www.readbyqxmd.com/read/28107310/the-renin-inhibitor-aliskiren-protects-rat-lungs-from-the-histopathologic-effects-of-fat-embolism
#3
Amanda N Fletcher, Agostino Molteni, Rakesh Ponnapureddy, Chirag Patel, Mark Pluym, Alan M Poisner
BACKGROUND: Fat embolism (FE) and the consequent FE syndrome occurring after trauma or surgery can lead to serious pulmonary injury, including ARDS and death. Current treatment of FE syndrome is limited to supportive therapy. We have shown in a rat model that the renin angiotensin system plays a significant role in the pathophysiology of FE because drugs interfering with the renin angiotensin system, captopril and losartan reduce the histopathologic pulmonary damage. The purpose of the current study was to determine if inhibition of renin by aliskiren, an FDA-approved drug for treating hypertension, would produce effective protection in the same model...
2017: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/28090416/post-traumatic-arthritis-of-the-tarsometatarsal-joint-complex-a-case-report
#4
Chirag Kapoor, Amit Patel, Maulik Jhaveri, Paresh Golwala
Tarsometatarsal (TMT) arthritis is characterized by instability and pain in the foot. The commonest cause is post-traumatic arthritis. A Lisfranc injury involves the articulation between the medial cuneiform and the base of the second metatarsal, which is considered a keystone to midfoot integrity. Neglected or undertreated injury to the Lisfranc joint complex leads to secondary arthritis and significant disability. We present a case of a young male patient with a two-year-old neglected Lisfranc joint injury and secondary osteoarthritis of the first, second, and fourth TMT joints, which we treated surgically with arthrodesis using screws, with a good functional outcome on final follow-up...
December 9, 2016: Curēus
https://www.readbyqxmd.com/read/28073808/fifteen-minute-consultation-assessment-of-a-child-with-suspected-shunt-problems
#5
Harpreet Singh Mangat, Chirag Patel, Desiderio Rodrigues
Cerebrospinal fluid diversion procedures have saved more lives than any other neurosurgical procedure. However, they do have a unique set of complications which a paediatrician in a district general hospital may encounter. Timely recognition and appropriate referral to the neurosurgeon is vital in order to avoid serious consequences and to have a favourable outcome.
January 10, 2017: Archives of Disease in Childhood. Education and Practice Edition
https://www.readbyqxmd.com/read/28068484/informatics-and-data-analytics-to-support-exposome-based-discovery-for-public-health
#6
Arjun K Manrai, Yuxia Cui, Pierre R Bushel, Molly Hall, Spyros Karakitsios, Carolyn J Mattingly, Marylyn Ritchie, Charles Schmitt, Denis A Sarigiannis, Duncan C Thomas, David Wishart, David M Balshaw, Chirag J Patel
The complexity of the human exposome-the totality of environmental exposures encountered from birth to death-motivates systematic, high-throughput approaches to discover the environmental determinants of disease. In this review, we describe the state of science in analyzing the human exposome and provide recommendations for the public health community to consider in dealing with analytic challenges of exposome-based biomedical research. We describe extant and novel analytic methods needed to associate the exposome with critical health outcomes and contextualize the data-centered challenges by drawing parallels to other research endeavors such as human genomics research...
December 23, 2016: Annual Review of Public Health
https://www.readbyqxmd.com/read/28053388/prevalence-of-deep-vein-thrombosis-in-patients-with-lower-limb-trauma
#7
Chirag S Kapoor, Ashit K Mehta, Krunal Patel, Paresh P Golwala
INTRODUCTION: Venous thrombo-embolism (VTE), which consists of deep vein thrombosis (DVT) and pulmonary embolism, is a potentially fatal condition. According to Western literature, DVT of lower limb veins is one of the most common complications following surgeries for lower limb. Few studies have been published from India on the subject and little is known about the true prevalence of the DVT and hence there are no clear guidelines regarding the prophylaxis for DVT for Indian patients...
October 2016: Journal of Clinical Orthopaedics and Trauma
https://www.readbyqxmd.com/read/28052169/updated-estimates-of-ectopic-pregnancy-among-commercially-and-medicaid-insured-women-in-the-united-states-2002-2013
#8
Guoyu Tao, Chirag Patel, Karen W Hoover
OBJECTIVES: To update trends in the rates of ectopic pregnancy, to compare rates of ectopic pregnancy between commercially insured and Medicaid-insured women, and to assess the differences in rates of ectopic pregnancy by different measures of ectopic pregnancy. METHODS: We analyzed data from 2002 to 2013 using the Truven Health MarketScan Commercial and Medicaid Claims Database. We limited the study population to women aged 15 to 44 years with any pregnancy in each year...
January 2017: Southern Medical Journal
https://www.readbyqxmd.com/read/28008773/radiotherapy-response-evaluation-using-fdg-pet-ct-established-and-emerging-applications
#9
Helen Cliffe, Chirag Patel, Robin Prestwich, Andrew Scarsbrook
Radiation therapy is a common component of curative cancer treatment. However, there is a significant incidence of treatment failure. In these cases salvage surgical options are sometimes appropriate. Accurate assessment of response and early recognition of treatment success or failure is therefore critical to guide treatment decisions and impacts on survival and the morbidity of treatment. Traditionally, treatment response has depended upon anatomical measurement of disease. However, this may not correlate well with the presence of disease, especially after radiotherapy...
December 23, 2016: British Journal of Radiology
https://www.readbyqxmd.com/read/28004391/should-race-genotype-interactions-be-considered-in-the-global-development-of-cyp2c19-substrates-a-proposed-framework-using-physiologically-based-pharmacokinetic-modeling
#10
Chirag Patel, Chetan Rathi, Karthik Venkatakrishnan
No abstract text is available yet for this article.
December 22, 2016: Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/28004011/methods-to-enhance-the-reproducibility-of-precision-medicine
#11
Arjun K Manrai, Chirag J Patel, Nils Gehlenborg, Nicholas P Tatonetti, John P A Ioannidis, Isaac S Kohane
No abstract text is available yet for this article.
2016: Pacific Symposium on Biocomputing
https://www.readbyqxmd.com/read/27970169/tct-782-peripheral-arterial-disease-hospitalization-trends-in-usa-2003-2013
#12
Prashant Patel, Shilpkumar Arora, Sopan Lahewala, Byomesh Tripathi, Nilay Patel, Chirag Savani, Kosha Thakore, Aditi Amin, Kriti Narwal, Sidakpal Panaich, Nileshkumar Patel, Apurva Badheka
No abstract text is available yet for this article.
November 1, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27970160/tct-773-thrombolysis-catheter-directed-systemic-in-pulmonary-embolism-predictors-and-etiologies-of-readmissions
#13
Prashant Patel, Shilpkumar Arora, Sopan Lahewala, Nilay Patel, Byomesh Tripathi, Purav Shah, Jaimin Trivedi, Harshil Shah, Chirag Bambhroliya, Smit Patel, Sidakpal Panaich, Abhishek Deshmukh, Apurva Badheka
No abstract text is available yet for this article.
November 1, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27970082/tct-702-transcatheter-aortic-valve-replacement-predictors-of-30-day-readmission-and-in-hospital-mortality-during-primary-and-readmission
#14
Sidakpal Panaich, Shilpkumar Arora, Nilay Patel, Smit Patel, Harshil Shah, Chirag Savani, Kriti Narwal, Kosha Thakore, Aditi Amin, Sopan Lahewala, Nileshkumar Patel, Ekta Aneja, Abhishek Deshmukh, Apurva Badheka
No abstract text is available yet for this article.
November 1, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27970051/tct-673-etiolgies-for-readmission-and-complications-following-transcatheter-aortic%C3%A2-valve-replacement-tavr-a-nationwide-perspective
#15
Ekta Aneja, Nilay Patel, Shilpkumar Arora, Sopan Lahewala, Sidakpal Panaich, Chirag Savani, Kriti Narwal, Smit Patel, Kosha Thakore, Aditi Amin, Nileshkumar Patel, Abhishek Deshmukh, Apurva Badheka
No abstract text is available yet for this article.
November 1, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27903014/effects-of-meteorological-variables-on-the-incidence-of-rupture-of-intracranial-aneurysms-in-central-new-jersey
#16
Marissa Kellogg, Dimitriy Petrov, Nitin Agarwal, Nitesh V Patel, David Richard Hansberry, Prateek Agarwal, Michael Brimacombe, Chirag D Gandhi, Charles Prestigiacomo
Introduction Previous studies have suggested relationships between the rupture of intracranial aneurysms and meteorological variables such as season, barometric pressure, and temperature. Our objective was to examine the relationship between the incidence of hospital admissions secondary to aneurysmal subarachnoid hemorrhage (aSAH) and meteorological variables in central New Jersey. Methods The study population consisted of 312 patients who presented to University Hospital in Newark, New Jersey, between January 1, 2003, and December 31, 2008, with aSAH...
November 30, 2016: Journal of Neurological Surgery. Part A, Central European Neurosurgery
https://www.readbyqxmd.com/read/27900230/giant-cell-tumour-of-proximal-phalanx-of-ring-finger-case-report-and-review-of-literature
#17
Rishit Soni, Chirag Kapoor, Malkesh Shah, Amit Patel, Paresh Golwala
Giant cell tumour (GCT) of bone arising from a phalanx of a finger is extremely rare. Only two percent of all reported GCTs are found in the hand, which show a higher rate of recurrence as compared to those occurring at a more proximal location. Here we report a rare case of giant cell tumour of proximal phalanx of the ring finger in a 20-year-old male, which was treated with extended curettage and bone grafting. After two years of follow-up, the patient was asymptomatic with complete functional recovery and no signs of recurrence...
October 18, 2016: Curēus
https://www.readbyqxmd.com/read/27896967/methods-to-ensure-the-reproducibility-of-biomedical-research
#18
Konrad J Karczewski, Nicholas P Tatonetti, Arjun K Manrai, Chirag J Patel, C Titus Brown, John P A Ioannidis
Science is not done in a vacuum - across fields of biomedicine, scientists have built on previous research and used data published in previous papers. A mainstay of scientific inquiry is the publication of one's research and recognition for this work is given in the form of citations and notoriety - ideally given in proportion to the quality of the work. Academic incentives, however, may encourage individual researchers to prioritize career ambitions over scientific truth. Recently, the New England Journal of Medicine published a commentary calling scientists who repurpose data "research parasites" who misuse data generated by others to demonstrate alternative hypotheses...
2016: Pacific Symposium on Biocomputing
https://www.readbyqxmd.com/read/27893593/trends-in-selected-measures-of-racial-and-ethnic-disparities-in-gonorrhea-and-syphilis-in-the-united-states-1981-2013
#19
Harrell W Chesson, Chirag G Patel, Thomas L Gift, Sevgi O Aral
BACKGROUND: The purpose of this study was to examine selected measures of racial and ethnic disparities in the reported incidence of syphilis and gonorrhea from 1981 to 2013 in the United States. METHODS: For each year, from 1981 to 2013, we calculated values for 5 disparity measures (Gini coefficient, 2 versions of the index of disparity, population attributable proportion, and the black-to-white rate ratio) for 5 racial/ethnic categories (non-Hispanic white, non-Hispanic black, Hispanic, American Indian/Alaska Native, and Asian/Pacific Islander)...
November 2016: Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/27881429/a-review-of-validation-strategies-for-computational-drug-repositioning
#20
Adam S Brown, Chirag J Patel
Repositioning of previously approved drugs is a promising methodology because it reduces the cost and duration of the drug development pipeline and reduces the likelihood of unforeseen adverse events. Computational repositioning is especially appealing because of the ability to rapidly screen candidates in silico and to reduce the number of possible repositioning candidates. What is unclear, however, is how useful such methods are in producing clinically efficacious repositioning hypotheses. Furthermore, there is no agreement in the field over the proper way to perform validation of in silico predictions, and in fact no systematic review of repositioning validation methodologies...
November 22, 2016: Briefings in Bioinformatics
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