Qianru Wang, Tiffany Tang, Nathan Youlton, Chad Weldy, Ana Kenney, Omer Ronen, John Hughes, Elizabeth Chin, Shirley Sutton, Abhineet Agarwal, Xiao Li, Merle Behr, Karl Kumbier, Christine Moravec, W H Wilson Tang, Kenneth Margulies, Thomas Cappola, Atul Butte, Rima Arnaout, James Brown, James Priest, Victoria Parikh, Bin Yu, Euan Ashley
The combinatorial effect of genetic variants is often assumed to be additive. Although genetic variation can clearly interact non-additively, methods to uncover epistatic relationships remain in their infancy. We develop low-signal signed iterative random forests to elucidate the complex genetic architecture of cardiac hypertrophy. We derive deep learning-based estimates of left ventricular mass from the cardiac MRI scans of 29,661 individuals enrolled in the UK Biobank. We report epistatic genetic variation including variants close to CCDC141 , IGF1R , TTN , and TNKS ...
November 20, 2023: Research Square