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Khushboo Patel, Basant Roondhe, Shweta D Dabhi, Prafulla K Jha
Recently predicted and grown new single element two dimensional (2D) material borophene gathered tremendous research interest due to its structural, electronic and other properties. Using first principles based dispersion corrected density functional calculations, we have studied interaction of two toxic gases phosgene (COCl2 ) and carbon monoxide (CO) with borophene to understand the role of borophene as biosensor and carriers in drug delivery. The sensing behaviour of borophene towards COCl2 and CO has been studied by calculating the binding energy and electronic density of states (DOS)...
March 7, 2018: Journal of Hazardous Materials
Alpesh A Patel, Shah-Nawaz M Dodwad, Barrett S Boody, Surabhi Bhatt, Jason W Savage, Wellington K Hsu, Nan E Rothrock
STUDY DESIGN: Prospective, cohort study. OBJECTIVE: Demonstrate validity of PROMIS physical function, pain interference, and pain behavior computer adaptive tests (CATs) in surgically treated lumbar stenosis patients. SUMMARY OF BACKGROUND DATA: There has been increasing attention given to patient reported outcomes associated with spinal interventions. Historical patient outcome measures have inadequate validation, demonstrate floor/ceiling effects, and infrequently used due to time constraints...
March 19, 2018: Spine
Vikram Patel, Kamaldeep Bhui
No abstract text is available yet for this article.
April 2018: British Journal of Psychiatry: the Journal of Mental Science
Jenna L Gollihue, Samir P Patel, Alexander G Rabchevsky
Mitochondria are essential cellular organelles critical for generating adenosine triphosphate for cellular homeostasis, as well as various mechanisms that can lead to both necrosis and apoptosis. The field of "mitochondrial medicine" is emerging in which injury/disease states are targeted therapeutically at the level of the mitochondrion, including specific antioxidants, bioenergetic substrate additions, and membrane uncoupling agents. Consequently, novel mitochondrial transplantation strategies represent a potentially multifactorial therapy leading to increased adenosine triphosphate production, decreased oxidative stress, mitochondrial DNA replacement, improved bioenergetics and tissue sparing...
February 2018: Neural Regeneration Research
Hessa S Alsaif, Arif O Khan, Nisha Patel, Hisham Alkuraya, Mais Hashem, Firdous Abdulwahab, Niema Ibrahim, Mohammed A Aldahmesh, Fowzan S Alkuraya
Primary congenital glaucoma is a trabecular meshwork dysgenesis with resultant increased intraocular pressure and ocular damage. CYP1B1 mutations remain the most common identifiable genetic cause. However, important questions about the penetrance of CYP1B1-related congenital glaucoma remain unanswered. Furthermore, mutations in other genes have been described although their exact contribution and potential genetic interaction, if any, with CYP1B1 mutations are not fully explored. In this study, we employed modern genomic approaches to re-examine CYP1B1-related congenital glaucoma...
March 19, 2018: Human Genetics
Tejas K Patel, Parvati B Patel
PURPOSE: The aim of this study was to estimate the prevalence of mortality among patients due to adverse drug reactions that lead to hospitalisation (fatal ADRAd ), to explore the heterogeneity in its estimation through subgroup analysis of study characteristics, and to identify system-organ classes involved and causative drugs for fatal ADRAd . METHODS: We identified prospective ADRAd -related studies via screening of the PubMed and Google Scholar databases with appropriate key terms...
March 19, 2018: European Journal of Clinical Pharmacology
Shashikant Sharma, Gowri K Uggini, Venus Patel, Isha Desai, Suresh Balakrishnan
Pesticide exposure to the non target groups especially during embryonic development has quite often resulted in congenital malformations. A commercially available combination insecticide (Ci, 50% chlorpyrifos and 5% cypermethrin) is known to induce ventral body wall defects (VBWDs) wherein abdominal viscera protrude out of the ventral body wall. Herein, an attempt was made to understand the mechanistic insight into Ci induced VBWDs. For this, before incubation, the chick embryos were dosed with the test chemical and then at different developmental stages of incubation, they were monitored for the changes in the expression of certain genes, which are indispensable for the ventral body wall closure since they regulate the cell fate, proliferation and survival...
2018: Toxicology Reports
Gopal R Gopinath, Hannah R Chase, Jayanthi Gangiredla, Athmanya Eshwar, Hyein Jang, Isha Patel, Flavia Negrete, Samantha Finkelstein, Eunbi Park, TaeJung Chung, YeonJoo Yoo, JungHa Woo, YouYoung Lee, Jihyeon Park, Hyerim Choi, Seungeun Jeong, Soyoung Jun, Mijeong Kim, Chaeyoon Lee, HyeJin Jeong, Séamus Fanning, Roger Stephan, Carol Iversen, Felix Reich, Günter Klein, Angelika Lehner, Ben D Tall
Background: Malonate utilization, an important differential trait, well recognized as being possessed by six of the seven Cronobacter species is thought to be largely absent in Cronobacter sakazakii (Csak). The current study provides experimental evidence that confirms the presence of a malonate utilization operon in 24 strains of sequence type (ST) 64, obtained from Europe, Middle East, China, and USA; it offers explanations regarding the genomic diversity and phylogenetic relatedness among these strains, and that of other C...
2018: Gut Pathogens
Shweta Patel, Sarmita Jana, Rajlakshmi Chetty, Sonal Thakore, Man Singh, Ranjitsinh Devkar
Titanium dioxide nanoparticles (TiO2 NPs) are among abundantly used metal oxide NPs but their interactions with biomolecules and subsequent embryonic toxicity in higher vertebrates is not extensively reported. Physicochemical interactions of TiO2 NPs with egg albumen reveals that lower doses of TiO2 NPs (10 and 25 µg/ml) accounted for higher friccohesity and activation energy but an increment in molecular radii was recorded at higher doses (50 and 100 µg/ml). FTIR analysis revealed conformational changes in secondary structure of egg albumen as a result of electrostratic interactions between egg albumen and TiO2 NPs...
March 19, 2018: Scientific Reports
Sarina R Isenberg, Norah L Crossnohere, Manali I Patel, Alison Conca-Cheng, John F P Bridges, Sandy M Swoboda, Thomas J Smith, Timothy M Pawlik, Matthew Weiss, Angelo E Volandes, Anne Schuster, Judith A Miller, Carolyn Pastorini, Debra L Roter, Rebecca A Aslakson
OBJECTIVE: Video-based advanc care planning (ACP) tools have been studied in varied medical contexts; however, none have been developed for patients undergoing major surgery. Using a patient- and family-centredness approach, our objective was to implement human-centred design (HCD) to develop an ACP decision support video for patients and their family members when preparing for major surgery. DESIGN AND METHODS: The study investigators partnered with surgical patients and their family members, surgeons and other health professionals to design an ACP decision support video using key HCD principles...
March 18, 2018: BMJ Supportive & Palliative Care
Anna Lahori, Jonathan Frogel, John G Augoustides, Prakash A Patel, William J Vernick, Jacob T Gutsche, Jared W Feinman, Saumil Patel, Ray Munroe, Emily J MacKay, Stuart J Weiss, Sanjay Dwarakanath, Richard D Sheu
No abstract text is available yet for this article.
February 12, 2018: Journal of Cardiothoracic and Vascular Anesthesia
Natalie A Silverton, Ravi Patel, Josh Zimmerman, Jianing Ma, Greg Stoddard, Craig Selzman, Candice K Morrissey
OBJECTIVE: To determine whether intraoperative measures of right ventricular (RV) function using transesophageal echocardiography are associated with subsequent RV failure after left ventricular assist device (LVAD) implantation. DESIGN: Retrospective, nonrandomized, observational study. SETTING: Single tertiary-level, university-affiliated hospital. PARTICIPANTS: The study comprised 100 patients with systolic heart failure undergoing elective LVAD implantation...
February 15, 2018: Journal of Cardiothoracic and Vascular Anesthesia
Jaideep Patel, Mahmoud Al Rifai, Maren T Scheuner, Steven Shea, Roger S Blumenthal, Khurram Nasir, Michael J Blaha, John W McEvoy
OBJECTIVE: To determine whether family history of coronary heart disease (FH) definitions differ in their association with atherosclerotic cardiovascular disease (ASCVD) events. PATIENTS AND METHODS: Participants who provided FH data from July 17, 2000, through February 24, 2004, were identified. Definitions of FH were any, premature, and Familial Risk Assessment (FRA). Outcomes included coronary heart disease (CHD), stroke, peripheral artery disease, angina, and congestive heart failure...
March 16, 2018: Mayo Clinic Proceedings
Ramesh J Pandit, Ankit T Hinsu, Shriram H Patel, Subhash J Jakhesara, Prakash G Koringa, Fosso Bruno, Androniki Psifidi, S V Shah, Chaitanya G Joshi
Zebu (Bos indicus) is a domestic cattle species originating from the Indian subcontinent and now widely domesticated on several continents. In this study, we were particularly interested in understanding the functionally active rumen microbiota of an important Zebu breed, the Gir, under different dietary regimes. Metagenomic and metatranscriptomic data were compared at various taxonomic levels to elucidate the differential microbial population and its functional dynamics in Gir cattle rumen under different roughage dietary regimes...
March 9, 2018: Systematic and Applied Microbiology
Sandeep Kumar Verma, Ashok Kumar Das, Manoj Kumar Patel, Ashish Shah, Vinay Kumar, Saikat Gantait
With the overwhelmingly rapid advancement in the field of nanotechnology, the engineered nanomaterials (ENMs) have been extensively used in various areas of the plant system, including quality improvement, growth and nutritional value enhancement, gene preservation etc. There are several recent reports on the ENMs' influence on growth enhancements, growth inhibition as well as certain toxic impacts on plant. However, translocation, growth responses and stress modulation mechanisms of ENMs in the plant systems call for better and in-depth understanding...
March 3, 2018: Science of the Total Environment
Vijay Patel, Debes Ray, Anita Bahadur, Junhe Ma, V K Aswal, Pratap Bahadur
The present study was aimed to examine the interaction of two bile salts viz. sodium cholate (NaC) and sodium deoxycholate (NaDC) with three ethylene polyoxide-polypropylene polyoxide (PEO-PPO-PEO) triblock copolymers with similar PPO but varying PEO micelles with a focus on the effect of pH on mixed micelles. Mixed micelles of moderately hydrophobic Pluronic® P123 were examined in the presence of two bile salts and compared with those from very hydrophobic L121 and very hydrophilic F127. Both the bile salts increase the cloud point (CP) of copolymer solution and decreased apparent micelle hydrodynamic diameter (Dh )...
March 2, 2018: Colloids and Surfaces. B, Biointerfaces
Eshan U Patel, Charlotte A Gaydos, Zoe R Packman, Thomas C Quinn, Aaron A R Tobian
Background: The epidemiology of Trichomonas vaginalis (TV) infection in the United States is poorly defined. Methods: Males and females aged 18-59 years who participated in the 2013-2014 National Health and Nutrition Examination Survey and provided a urine specimen were tested for TV infection (n = 4057). Participants were also examined for Chlamydia trachomatis (CT) infection, genital human papillomavirus (HPV) infection, and herpes simplex virus type 2 serostatus...
March 15, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
Theodorus M van Bakel, Christopher J Arthurs, Joost A van Herwaarden, Frans L Moll, Kim A Eagle, Himanshu J Patel, Santi Trimarchi, C Alberto Figueroa
OBJECTIVES: Aortic arch repair remains a major surgical challenge. Multiple manufacturers are developing branched endografts for Zone 0 endovascular repair, extending the armamentarium for minimally invasive treatment of aortic arch pathologies. We hypothesize that the design of the Zone 0 endograft has a significant impact on the postoperative haemodynamic performance, particularly in the cervical arteries. The goal of our study was to compare the postoperative haemodynamic performance of different Zone 0 endograft designs...
March 15, 2018: European Journal of Cardio-thoracic Surgery
Malkeshkumar Patel, Joondong Kim
The data presented in this article are related to the research article entitled "CuO photocathode-embedded semitransparent photoelectrochemical cell" (Patel et al., 2016) [1]. This article describes the growth of Cu oxides films using reactive sputtering and application of CuO photocathode in semitransparent photoelectrochemical cell (PEC). In this data article, physical, optical and electrical properties, and PEC performances data set of the reactively sputtered semitransparent CuO samples are made publicly available to enable extended analyses...
April 2018: Data in Brief
Nishant Patel, Ravi N Srinivasa, Joseph J Gemmete, Jeffrey Forris Beecham Chick
Biliary interventions are commonplace in interventional radiology. Occasionally, an anastomotic occlusion is encountered that cannot be traversed with fluoroscopy alone. Endoscopy is a tool that should be added to the interventional radiology armamentarium. Unfortunately, most departments do not have endoscopes regularly available for use by nonendoscopists. The disposable single-use flexible LithoVue scope has the potential to provide many applications for interventional radiologists. It is relatively low cost and is easy to use with a simple setup for novice endoscopists...
February 2018: Radiology Case Reports
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