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https://www.readbyqxmd.com/read/27936497/pro-inflammatory-cytokine-ifn%C3%AE-and-microbiome-derived-metabolites-dictate-epigenetic-switch-between-foxp3-isoforms-in-celiac-disease-regulation-of-foxp3-isoforms-in-celiac-disease
#1
Gloria Serena, Shu Yan, Stephanie Camhi, Shilpi Patel, Rosiane S Lima, Anna Sapone, Maureen M Leonard, Rupa Mukherjee, Barbara J Nath, Karen M Lammers, Alessio Fasano
Celiac disease (CD) is an autoimmune enteropathy triggered by gluten and characterized by a strong Th1/Th17 immune response in the small intestine. Treg cells are CD4(+) CD25(++) FOXP3(+) cells that regulate the immune response. Conversely to its counterpart, FOXP3 full length (FL), the alternatively spliced isoform FOXP3 Δ2 cannot properly down-regulate Th17 driven immune response. Since the active state of CD has been associated with impairments in Treg cell function, we aimed at determining whether imbalances between FOXP3 isoforms may be associated with the disease...
December 9, 2016: Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/27935952/neoadjuvant-gemcitabine-chemotherapy-followed-by-concurrent-imrt-simultaneous-boost-achieves-high-r0-resection-in-borderline-resectable-pancreatic-cancer-patients
#2
Xiaolun Huang, Jeanna L Knoble, Ming Zeng, Fernando N Aguila, Tara Patel, Lowell W Chambers, Honglin Hu, Hao Liu
BACKGROUND: To study the feasibility of down stage the borderline resectable pancreatic cancer (BRPC) to resectable disease, we reported our institutional results using an intensity-modulated radiation therapy (IMRT) simultaneous integrated boost (SIB) dose escalation approach to improve R0 resectability. METHODS: We reviewed our past 7 years of experience of using neoadjuvant induction chemotherapy with Gemcitabine followed by concurrent chemoradiaiton for BRPC...
2016: PloS One
https://www.readbyqxmd.com/read/27935921/isolated-pth-renal-resistance-pseudohypoparathyroidism-1b-a-rare-cause-of-hypocalcemia
#3
A Aggarwal, R Shah, O Mousa, A Patel
A case of Pseudohypoparathyroidism 1b is reported, who presented with signs and symptoms of hypocalcemia. Causes, diagnosis and management with new insight into genetic novel mutations in PHP are discussed. The objectives are to provide information regarding problems of Calcium balance, causes and making diagnosis of pseudohypoparathyroidism, learn complexities of PTH cellular interactions and calcium homeostasis and learn the genetic novel mutations of various types of PHP.
July 2016: JNMA; Journal of the Nepal Medical Association
https://www.readbyqxmd.com/read/27935909/exploring-the-diagnosis-and-management-of-bouveret-s-syndrome
#4
M Bhattarai, P Bansal, B Patel, A Lalos
Bouveret's syndrome is an unusual cause of gastric outlet obstruction secondary to gallstone impaction. It is so rare that it is commonly missed in clinical practice if it is not considered in differential diagnoses of intestinal obstruction more specifically in man who does not report the history of gall stone. Furthermore, there are no definitive guidelines on approach and management of this condition. We present a seventy eight year old man who developed acute abdominal symptoms due to impaction of a gallstone in the duodenum...
January 2016: JNMA; Journal of the Nepal Medical Association
https://www.readbyqxmd.com/read/27935905/socio-demographic-epidemiological-and-environmental-determinants-of-acute-gastroenteritis-in-western-india
#5
M P Rupani, A V Tridevi, M P Singh, M N Tundia, K N Patel, K D Parikh, V B Parmar
INTRODUCTION: An outbreak of acute gastroenteritis had occurred in Rajpara village of Bhavnagar district. The objective of this study was to find out the socio-demographic, epidemiological and environmental determinants of this outbreak. METHODS: A case-control study was conducted in Rajpara village among 238 cases of acute gastroenteritis and an equal number of controls in January 2015. Multiple logistic regression was used for identifying the variables independently predicting acute gastroenteritis...
January 2016: JNMA; Journal of the Nepal Medical Association
https://www.readbyqxmd.com/read/27935768/hypertrophic-osteoarthropathy-clinical-and-imaging-features
#6
Felix Y Yap, Matthew R Skalski, Dakshesh B Patel, Aaron J Schein, Eric A White, Anderanik Tomasian, Sulabha Masih, George R Matcuk
Hypertrophic osteoarthropathy (HOA) is a medical condition characterized by abnormal proliferation of skin and periosteal tissues involving the extremities and characterized by three clinical features: digital clubbing (also termed Hippocratic fingers), periostosis of tubular bones, and synovial effusions. HOA can be a primary entity, known as pachydermoperiostosis, or can be secondary to extraskeletal conditions, with different prognoses and management implications for each. There is a high association between secondary HOA and malignancy, especially non-small cell lung cancer...
December 9, 2016: Radiographics: a Review Publication of the Radiological Society of North America, Inc
https://www.readbyqxmd.com/read/27935338/pars-plana-vitrectomy-for-vitreomacular-traction-syndrome-analysing-the-preoperative-prognostic-factors
#7
Petros Petrou, Andreas Kontos, Marie-Hélène Errera, Philip J Banerjee, Sidath E Liyanage, Louisa Wickham, Krishna Patel, Ilias Georgalas, Efstratios Gotzaridis, Dimitris Papaconstantinou, David G Charteris
PURPOSE: To identify the prognostic factors affecting the surgical outcomes in patients with vitreomacular traction syndrome undergoing pars plana vitrectomy. METHODS: This was a retrospective clinical study of 67 eyes of 67 patients with vitreomacular traction syndrome who underwent pars plana vitrectomy. Demographic, clinical, and optical coherence tomography (OCT) characteristics were collected and analyzed. Univariate and multivariate linear regression analysis were used to examine the effect of parameters on change in best-corrected visual acuity (BCVA)...
December 9, 2016: Seminars in Ophthalmology
https://www.readbyqxmd.com/read/27934977/real-time-observation-of-protein-aggregates-in-pharmaceutical-formulations-using-liquid-cell-electron-microscopy
#8
Lynn M DiMemmo, A Cameron Varano, Jonathan Haulenbeek, Yanping Liang, Kaya Patel, Madeline J Dukes, Songyan Zheng, Mario Hubert, Steven P Piccoli, Deborah F Kelly
Understanding the properties of protein-based therapeutics is a common goal of biologists and physicians. Technical barriers in the direct observation of small proteins or therapeutic agents can limit our knowledge of how they function in solution and in the body. Electron microscopy (EM) imaging performed in a liquid environment permits us to peer into the active world of cells and molecules at the nanoscale. Here, we employ liquid cell EM to directly visualize a protein-based therapeutic in its native conformation and aggregate state in a time-resolved manner...
December 9, 2016: Lab on a Chip
https://www.readbyqxmd.com/read/27934777/rodent-model-for-assessing-the-long-term-safety-and-performance-of-peripheral-nerve-recording-electrodes
#9
Srikanth Vasudevan, Kunal Patel, Cristin Welle
OBJECTIVE: In the US alone, there are approximately 185 000 cases of limb amputation annually, which can reduce the quality of life for those individuals. Current prosthesis technology could be improved by access to signals from the nervous system for intuitive prosthesis control. After amputation, residual peripheral nerves continue to convey motor signals and electrical stimulation of these nerves can elicit sensory percepts. However, current technology for extracting information directly from peripheral nerves has limited chronic reliability, and novel approaches must be vetted to ensure safe long-term use...
December 9, 2016: Journal of Neural Engineering
https://www.readbyqxmd.com/read/27934650/parenteral-or-enteral-arginine-supplementation-safety-and-efficacy
#10
REVIEW
Martin D Rosenthal, Phillip W Carrott, Jayshil Patel, Laszlo Kiraly, Robert G Martindale
Arginine supplementation has the potential to improve the health of patients. Its use in hospitalized patients has been a controversial topic in the nutrition literature, especially concerning supplementation of septic patients. In this article, we review the relevant literature both for and against the use of arginine in critically ill, surgical, and hospitalized patients. The effect of critical illness on arginine metabolism is reviewed, as is its use in septic and critically ill patients. Although mounting evidence supports immunonutrition, there are only a few studies that suggest that this is safe in patients with severe sepsis...
December 2016: Journal of Nutrition
https://www.readbyqxmd.com/read/27934609/approaches-to-percutaneous-coronary-intervention-of-right-coronary-artery-chronic-total-occlusions-insights-from-a-multicentre-us-registry
#11
Aris Karatasakis, Dimitri Karmpaliotis, Khaldoon Alaswad, Farouc A Jaffer, Robert W Yeh, Mitul P Patel, John N Bahadorani, William L Lombardi, R Michael Wyman, J Aaron Grantham, David E Kandzari, Nicholas J Lembo, Anthony H Doing, Catalin Toma, Jeffrey W Moses, Ajay J Kirtane, Ziad Ali, Manish Parikh, Santiago Garcia, Barbara A Danek, Judit Karacsonyi, Aya Alame, Pratik Kalsaria, Craig Thompson, Subhash Banerjee, Emmanouil S Brilakis
AIMS: The goal of this study was to describe the procedural characteristics, strategy selection and associated technical and efficiency outcomes for chronic total occlusion (CTO) percutaneous coronary intervention (PCI) of the right coronary artery (RCA). METHODS AND RESULTS: We examined the clinical and angiographic characteristics of patients who underwent RCA CTO PCI between 2012 and 2015 at 11 centres in the USA. The RCA was the CTO target vessel in 739 of 1,308 CTO PCIs (56%)...
December 10, 2016: EuroIntervention
https://www.readbyqxmd.com/read/27934077/molding-inkjetted-silver-on-nanostructured-surfaces-for-high-throughput-structural-color-printing
#12
Hao Jiang, Sheida Alan, Haleh Shahbazbegian, Jasbir N Patel, Bozena Kaminska
Inkjet printing of silver ink has been widely used to print conductive patterns in flexible electronic devices, and the printed patterns are commonly known to be colorless. We demonstrate that by printing a single type of ordinary silver nanoparticle ink on top of a substrate patterned with polymer nanostructures, the printed silver is molded by the nanostructures and gains robust structural colors. The colors are tunable by varying the geometries of nanostructures, and a broad range of visual colors can be achieved by mixing the red, green, and blue colors displayed from silver dots printed on different nanostructures...
November 22, 2016: ACS Nano
https://www.readbyqxmd.com/read/27934011/a-mechanistic-model-for-colibactin-induced-genotoxicity
#13
Alan R Healy, Herman Nikolayevskiy, Jaymin R Patel, Jason M Crawford, Seth B Herzon
Precolibactins and colibactins represent a family of natural products that are encoded by the clb gene cluster and are produced by certain commensal, extraintestinal, and probiotic E. coli. clb(+) E. coli induce megalocytosis and DNA double-strand breaks in eukaryotic cells, but paradoxically, this gene cluster is found in the probiotic Nissle 1917. Evidence suggests precolibactins are converted to genotoxic colibactins by colibactin peptidase (ClbP)-mediated cleavage of an N-acyl-d-Asn side chain, and all isolation efforts have employed ΔclbP strains to facilitate accumulation of precolibactins...
December 7, 2016: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/27933945/fragment-based-approach-to-the-development-of-an-orally-bioavailable-lactam-inhibitor-of-lipoprotein-associated-phospholipase-a2-lp-pla2
#14
Alison J-A Woolford, Philip J Day, Véronique Bénéton, Valerio Berdini, Joseph E Coyle, Yann Dudit, Pascal Grondin, Pascal Huet, Lydia Y W Lee, Eric S Manas, Rachel L McMenamin, Christopher W Murray, Lee W Page, Vipulkumar K Patel, Florent Potvain, Sharna J Rich, Yingxia Sang, Don O Somers, Lionel Trottet, Zehong Wan, Xiaomin Zhang
Lp-PLA2 has been explored as a target for a number of inflammation associated diseases, including cardiovascular disease and dementia. This article describes the discovery of a new fragment derived chemotype that interacts with the active site of Lp-PLA2. The starting fragment hit was discovered through an X-ray fragment screen and showed no activity in the bioassay (IC50 > 1 mM). The fragment hit was optimized using a variety of structure-based drug design techniques, including virtual screening, fragment merging, and improvement of shape complementarity...
December 8, 2016: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/27933462/what-do-you-need-to-get-male-partners-of-pregnant-women-tested-for-hiv-in-resource-limited-settings-the-baby-shower-cluster-randomized-trial
#15
Echezona E Ezeanolue, Michael C Obiefune, Wei Yang, Chinenye O Ezeanolue, Jennifer Pharr, Alice Osuji, Amaka G Ogidi, Aaron T Hunt, Dina Patel, Gbenga Ogedegbe, John E Ehiri
Male partner involvement has the potential to increase uptake of interventions to prevent mother-to-child transmission of HIV (PMTCT). Finding cultural appropriate strategies to promote male partner involvement in PMTCT programs remains an abiding public health challenge. We assessed whether a congregation-based intervention, the Healthy Beginning Initiative (HBI), would lead to increased uptake of HIV testing among male partners of pregnant women during pregnancy. A cluster-randomized controlled trial of forty churches in Southeastern Nigeria randomly assigned to either the HBI (intervention group; IG) or standard of care referral to a health facility (control group; CG) was conducted...
December 8, 2016: AIDS and Behavior
https://www.readbyqxmd.com/read/27933437/focal-disruption-in-the-wall-of-the-porcelain-gallbladder-a-sign-of-gallbladder-carcinoma
#16
EDITORIAL
Mougnyan Cox, Manisha Patel, Upasana Joneja, Colette Shaw, Patrick O'Kane
No abstract text is available yet for this article.
December 8, 2016: Internal and Emergency Medicine
https://www.readbyqxmd.com/read/27933110/profiling-lung-adenocarcinoma-by-liquid-biopsy-can-one-size-fit-all
#17
Harry W Clifford, Amy P Cassidy, Courtney Vaughn, Evaline S Tsai, Bianka Seres, Nirmesh Patel, Hannah L O'Neill, Emil Hewage, John W Cassidy
BACKGROUND: Cancer is first and foremost a disease of the genome. Specific genetic signatures within a tumour are prognostic of disease outcome, reflect subclonal architecture and intratumour heterogeneity, inform treatment choices and predict the emergence of resistance to targeted therapies. Minimally invasive liquid biopsies can give temporal resolution to a tumour's genetic profile and allow the monitoring of treatment response through levels of circulating tumour DNA (ctDNA). However, the detection of ctDNA in repeated liquid biopsies is currently limited by economic and time constraints associated with targeted sequencing...
2016: Cancer Nanotechnology
https://www.readbyqxmd.com/read/27932832/should-implants-be-considered-for-patients-with-periodontal-disease
#18
E King, R Patel, A Patel, L Addy
Dental implants are seen as a good option for replacing missing teeth. The success and survival rates for implants are very high. Concerns are developing about the problem of peri-implantitis. The reports of its prevalence vary but it is noted that the presence of periodontal disease is a risk factor. The issue of peri-implantitis was raised in the House of Lords in 2014. Complaints relating to implants is on the rise with the General Dental Council. Placement of implants in patients with periodontal disease is not a treatment that should be done without a full periodontal assessment and stabilisation of periodontal disease first...
December 9, 2016: British Dental Journal
https://www.readbyqxmd.com/read/27932460/protein-o-linked-mannose-%C3%AE-1-4-n-acetylglucosaminyltransferase-2-pomgnt2-is-a-gatekeeper-enzyme-for-functional-glycosylation-of-%C3%AE-dystroglycan
#19
Stephanie M Halmo, Danish Singh, Sneha Patel, Shuo Wang, Melanie Edlin, Geert-Jan Boons, Kelley W Moremen, David Live, Lance Wells
Disruption of the O-mannosylation pathway involved in functional glycosylation of α-dystroglycan gives rise to congenital muscular dystrophies. Protein O-linked mannose β-1,4-N-acetylglucosaminyltransferase 2 (POMGNT2) catalyzes the first step towards the functional matriglycan structure on α-dystroglycan that is responsible for binding extracellular matrix proteins and certain arenaviruses. Alternatively, protein O-linked mannose β-1,2-N-acetylglucosaminyltransferase 1 (POMGNT1) catalyzes the first step towards other various glycan structures present on α-dystroglycan of unknown function...
December 8, 2016: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/27932305/scavenging-of-highly-reactive-gamma-ketoaldehydes-attenuates-cognitive-dysfunction-associated-with-epileptogenesis
#20
Jennifer N Pearson, Eric Warren, Li-Ping Liang, L Jackson Roberts, Manisha Patel
Cognitive dysfunction is a major comorbidity of the epilepsies; however, treatments targeting seizure-associated cognitive dysfunction, particularly deficits in learning and memory are not available. Isoketals and neuroketals, collectively known as gamma-ketoaldehydes are formed via the non-enzymatic, free radical catalyzed oxidation of arachidonic acid and docosahexaenoic acid, respectively. They are attractive candidates for oxidative protein damage and resultant cognitive dysfunction due to their formation within the plasma membrane and their high proclivity to form cytotoxic adducts on protein lysine residues...
December 5, 2016: Neurobiology of Disease
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