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https://www.readbyqxmd.com/read/28212575/upregulation-of-mucin-glycoprotein-muc1-in-the-progression-to-esophageal-adenocarcinoma-and-therapeutic-potential-with-a-targeted-photoactive-antibody-drug-conjugate
#1
Mohammed Adil Butt, Hayley Pye, Rehan J Haidry, Dahmane Oukrif, Saif-U-Rehman Khan, Ignazio Puccio, Michael Gandy, Halla W Reinert, Ellie Bloom, Mohammed Rashid, Gokhan Yahioglu, Mahendra P Deonarain, Rifat Hamoudi, Manuel Rodriguez-Justo, Marco R Novelli, Laurence B Lovat
BACKGROUND: Mucin glycoprotein 1 (MUC1) is a glycosylated transmembrane protein on epithelial cells. We investigate MUC1 as a therapeutic target in Barrett's epithelium (BE) and esophageal adenocarcinoma (EA) and provide proof of concept for a light based therapy targeting MUC1. RESULTS: MUC1 was present in 21% and 30% of significantly enriched pathways comparing BE and EA to squamous epithelium respectively. MUC1 gene expression was x2.3 and x2.2 higher in BE (p=<0...
February 15, 2017: Oncotarget
https://www.readbyqxmd.com/read/28207920/paper-based-microfluidic-system-for-tear-electrolyte-analysis
#2
Ali K Yetisen, Nan Jiang, Ali Tamayol, Guillermo U Ruiz-Esparza, Yu Shrike Zhang, Sofía Medina-Pando, Aditi Gupta, James S Wolffsohn, Haider Butt, Ali Khademhosseini, Seok-Hyun Yun
The analysis of tear constituents at point-of-care settings has a potential for early diagnosis of ocular disorders such as dry eye disease, low-cost screening, and surveillance of at-risk subjects. However, current minimally-invasive rapid tear analysis systems for point-of-care settings have been limited to assessment of osmolarity or inflammatory markers and cannot differentiate between dry eye subclassifications. Here, we demonstrate a portable microfluidic system that allows quantitative analysis of electrolytes in the tear fluid that is suited for point-of-care settings...
February 16, 2017: Lab on a Chip
https://www.readbyqxmd.com/read/28198881/mode-evolution-based-coupler-for-high-saturation-power-ge-on-si-photodetectors
#3
Matthew J Byrd, Erman Timurdogan, Zhan Su, Christopher V Poulton, Nicholas M Fahrenkopf, Gerald Leake, Douglas D Coolbaugh, Michael R Watts
We propose a mode-evolution-based coupler for high saturation power germanium-on-silicon photodetectors. This coupler uniformly illuminates the intrinsic germanium region of the detector, decreasing saturation effects, such as carrier screening, observed at high input powers. We demonstrate 70% more photocurrent generation (9.1-15.5 mA) and more than 40 times higher opto-electrical bandwidth (0.7-31 GHz) than conventional butt-coupled detectors under high-power illumination. The high-power and high-speed performance of the device, combined with the compactness of the coupling method, will enable new applications for integrated silicon photonics systems...
February 15, 2017: Optics Letters
https://www.readbyqxmd.com/read/28197999/parallel-experimental-design-and-multivariate-analysis-provides-efficient-screening-of-cell-culture-media-supplements-to-improve-biosimilar-product-quality
#4
David Brühlmann, Michael Sokolov, Alessandro Butté, Markus Sauer, Jürgen Hemberger, Jonathan Souquet, Hervé Broly, Martin Jordan
Rational and high-throughput optimization of mammalian cell culture media has a great potential to modulate recombinant protein product quality. We present a process design method based on parallel design-of-experiment (DoE) of CHO fed-batch cultures in 96-deepwell plates to modulate monoclonal antibody (mAb) glycosylation using medium supplements. To reduce risk of losing valuable information in an intricate joint screening, 17 compounds were separated into five different groups, considering their mode of biological action...
February 15, 2017: Biotechnology and Bioengineering
https://www.readbyqxmd.com/read/28195666/stable-hydrophobic-metal-oxide-photocatalysts-via-grafting-polydimethylsiloxane-brush
#5
Sanghyuk Wooh, Noemí Encinas, Doris Vollmer, Hans-Jürgen Butt
Polydimethylsiloxane (PDMS) can be grafted to metal-oxide photocatalysts such as titanium oxide by simple UV irradiation in solution or melt. The PDMS graft metal oxides are still photocatalytically active. They are hydrophobic, liquid repellent, self-cleaning, prevent biofouling and are long-term stable even in UV light.
February 14, 2017: Advanced Materials
https://www.readbyqxmd.com/read/28195436/glucose-sensitive-hydrogel-optical-fibers-functionalized-with-phenylboronic-acid
#6
Ali K Yetisen, Nan Jiang, Afsoon Fallahi, Yunuen Montelongo, Guillermo U Ruiz-Esparza, Ali Tamayol, Yu Shrike Zhang, Iram Mahmood, Su-A Yang, Ki Su Kim, Haider Butt, Ali Khademhosseini, Seok-Hyun Yun
Hydrogel optical fibers are utilized for continuous glucose sensing in real time. The hydrogel fibers consist of poly(acrylamide-co-poly(ethylene glycol) diacrylate) cores functionalized with phenylboronic acid. The complexation of the phenylboronic acid and cis-diol groups of glucose enables reversible changes of the hydrogel fiber diameter. The analyses of light propagation loss allow for quantitative glucose measurements within the physiological range.
February 13, 2017: Advanced Materials
https://www.readbyqxmd.com/read/28195198/the-gadolinium-gd-3-and-tin-sn-4-co-doped-bifeo3-nanoparticles-as-new-solar-light-active-photocatalyst
#7
Syed Irfan, Syed Rizwan, Yang Shen, Liangliang Li, Asfandiyar, Sajid Butt, Ce-Wen Nan
The process of photocatalysis is appealing to huge interest motivated by the great promise of addressing current energy and environmental issues through converting solar light directly into chemical energy. However, an efficient solar energy harvesting for photocatalysis remains a critical challenge. Here, we reported a new full solar spectrum driven photocatalyst by co-doping of Gd(3+) and Sn(4+) into A and B-sites of BiFeO3 simultaneously. The co-doping of Gd(3+) and Sn(4+) played a key role in hampering the recombination of electron-hole pairs and shifted the band-gap of BiFeO3 from 2...
February 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28191461/three-class-mammogram-classification-based-on-descriptive-cnn-features
#8
M Mohsin Jadoon, Qianni Zhang, Ihsan Ul Haq, Sharjeel Butt, Adeel Jadoon
In this paper, a novel classification technique for large data set of mammograms using a deep learning method is proposed. The proposed model targets a three-class classification study (normal, malignant, and benign cases). In our model we have presented two methods, namely, convolutional neural network-discrete wavelet (CNN-DW) and convolutional neural network-curvelet transform (CNN-CT). An augmented data set is generated by using mammogram patches. To enhance the contrast of mammogram images, the data set is filtered by contrast limited adaptive histogram equalization (CLAHE)...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28185651/the-ugly-face-of-tourism-marine-debris-pollution-linked-to-visitation-in-the-southern-great-barrier-reef-australia
#9
Scott P Wilson, Krista M Verlis
Marine debris is one of the most significant issues facing oceans worldwide. The sources of this debris vary depending on proximity to urban centres and the nature of activities within an area. This paper examines the influence of tourism in the southern Great Barrier Reef (GBR), and its contribution to litter levels in the region. By conducting beach debris surveys on occupied and unoccupied islands, this study found that debris was prevalent throughout the region with significant differences in material types between locations...
February 6, 2017: Marine Pollution Bulletin
https://www.readbyqxmd.com/read/28177245/controlling-the-structure-of-supraballs-by-ph-responsive-particle-assembly
#10
Takafumi Sekido, Sanghyuk Wooh, Regina Fuchs, Michael Kappl, Yoshinobu Nakamura, Hans-Jürgen Butt, Syuji Fujii
Supraballs of various sizes and compositions can be fabricated via drying of drops of aqueous colloidal dispersions on super-liquid-repellent surfaces with no chemical waste and energy consumption. A "supraball" is a particle composed of colloids. Many properties, such as mechanical strength and porosity, are determined by the ordering of a colloidal assembly. To tune such properties, a colloidal assembly needs to be controlled when supraballs are formed during drying. Here, we introduce a method to control a colloidal assembly of supraballs by adjusting the dispersity of the colloids...
February 17, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28174919/op030-identification-of-disease-relevant-bacterial-signatures-in-gnotobiotic-il-10-deficient-mice-using-fecal-samples-from-ibd-patients-undergoing-hematopoietic-stem-cell-transplantation
#11
A Metwaly, L F Butt, N Waldschmitt, I Lagkouvardos, A M Corraliza, A Mayorgas, M Martinez-Medina, M Allez, J Panes, A Salas, D Haller
No abstract text is available yet for this article.
February 1, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28166473/a-retrospective-analysis-of-the-outcomes-of-smoking-cessation-pharmacotherapy-among-persons-with-mental-health-and-substance-use-disorders
#12
Chizimuzo T C Okoli, Vivek Anand, Milan Khara
OBJECTIVES: It is common practice to individualize smoking cessation pharmacotherapy based on clinical judgement and patient response. However, little has been documented about the use and outcomes of smoking cessation pharmacotherapy in 'real world' settings. This study examines factors associated with using smoking cessation pharmacotherapy and related outcomes among smokers with psychiatric and/or substance use disorders who completed an intensive tobacco treatment program within mental health and addictions services settings in Vancouver, Canada...
February 6, 2017: Journal of Dual Diagnosis
https://www.readbyqxmd.com/read/28163669/college-anti-smoking-policies-and-student-smoking-behavior-a-review-of-the-literature
#13
REVIEW
Brooke L Bennett, Melodi Deiner, Pallav Pokhrel
BACKGROUND: Currently, most college campuses across the U.S. in some way address on-campus cigarette smoking, mainly through policies that restrict smoking on campus premises. However, it is not well understood whether college-level anti-smoking policies help reduce cigarette smoking among students. In addition, little is known about policies that may have an impact on student smoking behavior. This study attempted to address these issues through a literature review. METHODS: A systematic literature review was performed...
2017: Tobacco Induced Diseases
https://www.readbyqxmd.com/read/28157679/myelofibrosis-secondary-to-renal-osteodystrophy
#14
Yasmeen M Butt, Weina Chen
No abstract text is available yet for this article.
October 20, 2016: Blood
https://www.readbyqxmd.com/read/28149238/beware-flammable-fingernails-case-report-synthetic-fingernails-result-in-full-thickness-burn-and-terminalisation
#15
A Arnaout, J Cubitt, D Nguyen
Having long artificial (acrylic) nails is a current fashion trend, and they are becoming an increasingly popular cosmetic enhancement. We believe that they can be a potential burn hazard to their unknowing users. We present the first reported case in medical literature of a woman whose acrylic nail ignited from a cigarette butt a short distance from the nail while she was taking the final puffs. She sustained a full thickness burn to her dominant left thumb, resulting in terminalisation. Acrylic nails are very flammable and, once ignited, they burn to completion, with the source of flame removed...
June 30, 2016: Annals of Burns and Fire Disasters
https://www.readbyqxmd.com/read/28138977/global-epidemiological-trends-and-variations-in-the-burden-of-gallbladder-cancer
#16
Chandrakanth Are, Humera Ahmad, Advaitaa Ravipati, Darren Croo, Dillon Clarey, Lynette Smith, Ray R Price, Jean M Butte, Sameer Gupta, Arun Chaturvedi, Sanjib Chowdhury
BACKGROUND: The aim of this study is to describe the trends and variations in the global burden of gallbladder cancer (GBC) with an emphasis on geographic variations and female gender. METHODS: Data (2012-2030) relating to GBC was extracted from GLOBOCAN 2012 database and analyzed. RESULTS: The results of our study document a rising global burden of GBC with geographic and gender variations. The highest burden was noted in the WPRO region (based on WHO regions), Asia (based on continents) and India, Chile, and China (based on countries)...
January 30, 2017: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28130810/shift-in-disparities-in-hepatitis-c-treatment-from-interferon-to-daa-era-a-population-based-cohort-study
#17
Naveed Z Janjua, Nazrul Islam, Jason Wong, Eric M Yoshida, Alnoor Ramji, Hasina Samji, Zahid A Butt, Mei Chong, Darrel Cook, Maria Alvarez, Maryam Darvishian, Mark Tyndall, Mel Krajden
We evaluated the shift in the characteristics of people who received interferon-based Hepatitis C virus (HCV) treatments and those who received recently introduced direct-acting antivirals (DAAs) in British Columbia (BC), Canada. The BC Hepatitis Testers Cohort includes 1.5 million individuals tested for HCV, HIV, reported cases of hepatitis B, and active tuberculosis in BC from 1990-2013 linked to medical visits, hospitalization, cancer, prescription drugs and mortality data. This analysis included all patients who filled at least one prescription for HCV treatment until July 31, 2015...
January 27, 2017: Journal of Viral Hepatitis
https://www.readbyqxmd.com/read/28125637/functional-characterization-of-cotton-gamyb62l-a-novel-r2r3-tf-in-transgenic-arabidopsis
#18
Hamama Islam Butt, Zhaoen Yang, Eryong Chen, Ge Zhao, Qian Gong, Zuoren Yang, Xueyan Zhang, Fuguang Li
Drought stress can trigger the production of ABA in plants, in response to adverse conditions, which induces the transcript of stress-related marker genes. The R2R3 MYB TFs are implicated in regulation of various plants developmental, metabolic and multiple environmental stress responses. Here, a R2R3-MYB cloned gene, GaMYB62L, was transformed in Arabidopsis and was functionally characterized. The GaMYB62L protein contains two SANT domains with a conserved R2R3 imperfect repeats. The GaMYB62L cDNA is 1,017 bp with a CDS of 879, encodes a 292-residue polypeptide with MW of 38...
2017: PloS One
https://www.readbyqxmd.com/read/28122034/a-low-peripheral-blood-cd4-cd8-ratio-is-associated-with-pulmonary-emphysema-in-hiv
#19
Matthew Triplette, Engi F Attia, Kathleen M Akgün, Guy W Soo Hoo, Matthew S Freiberg, Adeel A Butt, Cherry Wongtrakool, Matthew Bidwell Goetz, Sheldon T Brown, Christopher J Graber, Laurence Huang, Kristina Crothers
OBJECTIVES: The prevalence of emphysema is higher among HIV-infected (HIV+) individuals compared to HIV-uninfected persons. While greater tobacco use contributes, HIV-related effects on immunity likely confer additional risk. Low peripheral blood CD4+ to CD8+ T-lymphocyte (CD4/CD8) ratio may reflect chronic inflammation in HIV and may be a marker of chronic lung disease in this population. Therefore, we sought to determine whether the CD4/CD8 ratio was associated with chronic obstructive pulmonary disease (COPD), particularly the emphysema subtype, in a cohort of HIV+ subjects...
2017: PloS One
https://www.readbyqxmd.com/read/28118430/-move-your-arm-like-a-swan-dance-for-pd-demedicalizes-parkinson-disease
#20
Carrie A Butt
No abstract text is available yet for this article.
January 24, 2017: JAMA: the Journal of the American Medical Association
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