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https://www.readbyqxmd.com/read/28097735/autoimmune-enteropathy-and-hepatitis-in-pediatric-heart-transplant-recipient
#1
Kimberly Lewis, Ryan Butts, J Antonio Quiros, Michelle Hudspeth, Katherine Twombley, Andrew Savage, Sally Self, Ali Burnette, Shaoli Sun
AIE is a rare disorder in children that presents with severe diarrhea and malabsorption, caused by immune-mediated damage to intestinal mucosa. AIE is often associated with various syndromes of immunodeficiency including IPEX syndrome (immune dysregulation, polyendocrinopathy and enteropathy, X-linked). Dysfunctional T regulatory cells are the source of pathology in both IPEX syndrome and AIE as they are essential in maintaining tolerance to self-antigens and eliminating autoreactive B cells. This case report describes a 10-year-old cardiac transplant and total thymectomy patient on chronic immunosuppression with tacrolimus that presented with AIE and extraintestinal manifestations of cyclical hepatitis...
January 17, 2017: Pediatric Transplantation
https://www.readbyqxmd.com/read/28095793/genetic-variation-underlying-renal-uric-acid-excretion-in-hispanic-children-the-viva-la-familia-study
#2
Geetha Chittoor, Karin Haack, Nitesh R Mehta, Sandra Laston, Shelley A Cole, Anthony G Comuzzie, Nancy F Butte, V Saroja Voruganti
BACKGROUND: Reduced renal excretion of uric acid plays a significant role in the development of hyperuricemia and gout in adults. Hyperuricemia has been associated with chronic kidney disease and cardiovascular disease in children and adults. There are limited genome-wide association studies associating genetic polymorphisms with renal urate excretion measures. Therefore, we investigated the genetic factors that influence the excretion of uric acid and related indices in 768 Hispanic children of the Viva La Familia Study...
January 17, 2017: BMC Medical Genetics
https://www.readbyqxmd.com/read/28091630/accurate-measurement-of-long-range-proton-carbon-scalar-coupling-constants
#3
Claire L Dickson, Charles D Blundell, Craig P Butts, Alice Felton, Alex Jeffreys, Zoltan Takacs
The accuracy and practicality of measuring heteronuclear scalar coupling constants, (n)JCH, from modern NMR experimental methods is examined, based on F1 or F2 evolution of (n)JCH in HSQMBC (including EXSIDE) and HMBC experiments. The results from these methods are compared to both robust experimental data (derived from coupled (13)C spectra), computed (Density Functional Theory) and literature values where available. We report on the accuracy, ease of use and time efficiency of these multi-dimensional methods and highlight their extent and limitations...
January 16, 2017: Analyst
https://www.readbyqxmd.com/read/28089717/persistent-organic-pollutants-pops-in-human-follicular-fluid-and-in-vitro-fertilization-outcomes-a-pilot-study
#4
Michael S Bloom, Victor Y Fujimoto, Robin Storm, Li Zhang, Celeste D Butts, Diana Sollohub, Robert L Jansing
Persistent organic pollutants (POPs) are ubiquitously distributed among the U.S. population and adversely impact human reproduction. These compounds have been detected in human ovarian follicular fluid (FF), where they directly contact a developing oocyte. As a pilot investigation, we measured 43 polychlorinated biphenyl (PCB) congeners, p,p'-dichlorodiphenyltrichloroethane (DDT), and its persistent metabolite p,p'-dichlorodiphenyldichloroethylene (DDE) in residual FF collected from 32 women undergoing in vitro fertilization (IVF)...
January 9, 2017: Reproductive Toxicology
https://www.readbyqxmd.com/read/28077045/association-of-time-to-antibiotics-and-clinical-outcomes-in-adult-hematologic-malignancy-patients-with-febrile-neutropenia
#5
Allison R Butts, Christina Carracedo Bachmeier, Emily V Dressler, Meng Liu, Ann Cowden, Jeff Talbert, Val R Adams
Objective The objective of this study was to determine the clinical impact of time to antibiotic administration in adult inpatients who have hematologic malignancies and develop febrile neutropenia. Methods A retrospective chart review was conducted to screen for all febrile neutropenia events amongst adult hematologic malignancy patients between 1 January 2010 and 1 September 2014. All included patients were admitted to the hospital at the time of fever onset, having been admitted for a diagnosis other than febrile neutropenia...
January 1, 2017: Journal of Oncology Pharmacy Practice
https://www.readbyqxmd.com/read/28074986/-recommendations-for-the-management-of-pancreatic-cancer-type-adenocarcinoma-a-consensus-statement-reached-during-the-2015-latin-american-symposium-on-gastroenterological-oncology
#6
Christian Caglevic, Jorge Gallardo, Marcela de la Torre, Mauricio Mahave, Bettina Müller, Sebastián Solé, Yuri Moscoso, Hernán De La Fuente, Juan Carlos Roa, Sebastián Hoefler, Jean M Butte, Pablo González M, Juan Manuel O'Connor, Javiera Torres, Verónica Pérez Encalada, Daniel Alarcón Cano, Luis Ubillos, Christian Rolfo, Alejo Lingua, Consuelo Díaz Romero, Alejandro Padilla Rosciano, Viviana Cuartero, Germán Calderillo Ruiz, Gilberto Schwartsmann, Xavier Kon Jara, Andrés Andrade G, Luis Mas López, Olga Barajas, Marcela Carballido, Hanns Lembach, Lena Morillas G, Enrique Roca, José Lobatón, Paola Montenegro B, Andrés Yepes, Hugo Marsiglia
Pancreatic cancer is a malignancy of great impact in developed countries and is having an increasing impact in Latin America. Incidence and mortality rates are similar for this cancer. This is an important reason to offer to the patients the best treatments available. During the Latin American Symposium of Gastroenterology Oncology (SLAGO) held in Viña del Mar, Chile, in April 2015, a multidisciplinary group of specialists in the field met to discuss about this disease. The main conclusions of this meeting, where practitioners from most of Latin American countries participated, are listed in this consensus that seek to serve as a guide for better decision making for patients with pancreatic cancer in Latin America...
October 2016: Revista Médica de Chile
https://www.readbyqxmd.com/read/28072632/asc-methylation-and-interleukin-1%C3%AE-are-associated-with-aerobic-capacity-in-heart-failure
#7
Brittany Butts, Javed Butler, Sandra B Dunbar, Elizabeth Corwin, Rebecca A Gary
BACKGROUND: Aerobic capacity, as measured by peak oxygen uptake (V[Combining Dot Above]O2), is one of the most powerful predictors of prognosis in heart failure (HF). Inflammation is a key factor contributing to alterations in aerobic capacity, and interleukin (IL)-1 cytokines are implicated in this process. The adaptor protein ASC is necessary for inflammasome activation of IL-1β and IL-18. ASC expression is controlled through epigenetic modification; lower ASC methylation is associated with worse outcomes in HF...
January 9, 2017: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/28066547/holographic-direct-pulsed-laser-writing-of-two-dimensional-nanostructures
#8
Bader AlQattan, Haider Butt, Aydin Sabouri, Ali K Yetisen, Rajib Ahmed, Nasim Mahmoodi
The development of accurate and rapid techniques to produce nanophotonic structures is essential in data storage, sensors, and spectroscopy. Existing bottom-up and top-down approaches to fabricate nanophotonic devices are high cost and time consuming, limiting their mass manufacturing and practical applications. Here, we demonstrate a strategy to rapidly create 25-40 nm thick 1/2D Au-Ti nanopatterns using holographic direct laser interference patterning (DLIP). Pulses of an Nd:YAG laser (1064 nm) in holographic Denisyuk reflection mode were used to create ablative interference fringes...
December 4, 2016: RSC Advances
https://www.readbyqxmd.com/read/28064423/pathophysiology-diagnosis-and-management-of-glaucoma-associated-with-sturge-weber-syndrome
#9
REVIEW
Usman Javaid, Muhammad Hassaan Ali, Samreen Jamal, Nadeem Hafeez Butt
PURPOSE: Sturge-Weber syndrome (SWS), also known as encephalotrigeminal angiomatosis, is a condition which includes leptomeningeal hemangioma, facial angiomatosis or nevus flammeus, and ocular changes. SWS can lead to severe complications of anterior segment involving conjunctiva and eyelids, whereas posterior segment of the eye may also be affected by diffuse choroidal hemorrhages. This article was written with the objectives to determine the pathophysiology, diagnosis, and treatment of glaucoma associated with this rare and challenging disorder...
January 7, 2017: International Ophthalmology
https://www.readbyqxmd.com/read/28063550/d%C3%A3-termination-de-l-%C3%A3-ge-gestationnel-par-%C3%A3-chographie
#10
Kimberly Butt, Ken Lim
OBJECTIF: Aider les cliniciens à attribuer un âge gestationnel en fonction des résultats de la biométrie échographique. ISSUES: Déterminer si la datation par échographie offre une évaluation plus précise de l'âge gestationnel que la datation en fonction des dernières règles avec ou sans recours à l'échographie. Offrir, aux praticiens et aux chercheurs du domaine des soins de maternité, des lignes directrices factuelles en matière d'attribution de l'âge gestationnel...
December 2016: Journal of Obstetrics and Gynaecology Canada: JOGC, Journal D'obstétrique et Gynécologie du Canada: JOGC
https://www.readbyqxmd.com/read/28062026/mise-%C3%A3-jour-technique-sur-la-physiologie-et-l-%C3%A3-valuation-du-liquide-amniotique
#11
Kenneth I Lim, Kimberly Butt, Kentia Naud, Mila Smithies
OBJECTIF: RéSULTATS: SOURCES DES DONNéES PROBANTES: Nous avons effectué une recherche sur MEDLINE et Kfinder pour trouver des articles pertinents, puis avons examiné les bibliographies des articles retenus, notamment des revues Cochrane et des articles de revue récents. VALEURS: Les données recueillies ont été analysées par le Comité d'imagerie diagnostique de la Société des obstétriciens et gynécologues du Canada. Les recommandations ont été classées selon les critères établis par le Groupe d'étude canadien sur les soins de santé préventifs (Tableau 1)...
January 2017: Journal of Obstetrics and Gynaecology Canada: JOGC, Journal D'obstétrique et Gynécologie du Canada: JOGC
https://www.readbyqxmd.com/read/28062025/amniotic-fluid-technical-update-on-physiology-and-measurement
#12
Kenneth I Lim, Kimberly Butt, Kentia Naud, Mila Smithies
OBJECTIVE: OUTCOMES: EVIDENCE: A MEDLINE and KFINDER search was used to identify relevant articles, with review of bibliography identified article including Cochrane reviews and recent review articles. VALUES: The evidence collected was reviewed by the Diagnostic Imaging Committee of the Society of Obstetricians and Gynecologists of Canada. The recommendations were made according to the guidelines developed by The Canadian Task Force on Preventative Health Care (Table 1)...
January 2017: Journal of Obstetrics and Gynaecology Canada: JOGC, Journal D'obstétrique et Gynécologie du Canada: JOGC
https://www.readbyqxmd.com/read/28059289/mode-selective-coupling-between-few-mode-fibers-and-buried-channel-waveguides
#13
Yunfei Wu, Kin Seng Chiang
With intensive computation, we analyze in detail butt-coupling between few-mode fibers and buried channel waveguides and discuss, in particular, the conditions to achieve mode-selective coupling for the first 6 spatial modes. In the case of coupling a buried rectangular-core waveguide to a step-index or a parabolic-index circular-core fiber, a modal crosstalk smaller than -20 dB for all the 6 spatial modes can be achieved, when the shape of the waveguide core is sufficiently close to a square (within ± 0.7% variation in its aspect ratio) and the waveguide and the fiber have close mode volumes...
December 26, 2016: Optics Express
https://www.readbyqxmd.com/read/28058079/zollinger-ellison-syndrome-a-rare-case-of-chronic-diarrhea
#14
Ali Aamar, Kamraan Madhani, Hafeezulhassan Virk, Zeeshan Butt
Zollinger-Ellison syndrome (ZES) is caused by hypersecretion of gastrin from duodenal or pancreatic gastrinomas. We report a case of a 57-year-old female who presented with chronic diarrhea. CT abdomen showed multiple liver masses. Liver biopsy suggested metastatic well-differentiated neuroendocrine tumor. Serum gastrin level was markedly elevated. MRI abdomen, somatostatin receptor scintigraphy and endoscopic ultrasound failed to reveal primary site of the tumor. Upper gastrointestinal endoscopy showed hyperplastic gastric folds and multiple duodenal ulcers consistent with ZES...
December 2016: Gastroenterology Research
https://www.readbyqxmd.com/read/28057685/rimmport-an-r-bioconductor-package-that-enables-ready-for-analysis-immunology-research-data
#15
Ravi D Shankar, Sanchita Bhattacharya, Chethan Jujjavarapu, Sandra Andorf, Jeffery A Wiser, Atul J Butte
: : Open access to raw clinical and molecular data related to immunological studies has created a tremendous opportunity for data-driven science. We have developed RImmPort that prepares NIAID-funded research study datasets in ImmPort (immport.org) for analysis in R. RImmPort comprises of three main components: (i) a specification of R classes that encapsulate study data, (ii) foundational methods to load data of a specific study and (iii) generic methods to slice and dice data across different dimensions in one or more studies...
January 5, 2017: Bioinformatics
https://www.readbyqxmd.com/read/28045140/precipitation-selex-identification-of-dna-aptamers-for-calcium-phosphate-materials-synthesis
#16
K R Baillargeon, K Meserve, S Faulkner, S Watson, H Butts, P Deighan, A E Gerdon
DNA aptamers that enhance calcium phosphate mineral formation were identified using a novel precipitation SELEX method. The evolved DNA library was substantially enriched in G nucleotides and in predicted G-quadruplex structures, suggesting their importance in the mechanism of mineralization. This work could readily be extended to provide additional novel DNA aptamers for materials synthesis.
January 3, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28043455/validation-of-a-simple-score-to-determine-risk-of-hospital-mortality-after-the-norwood-procedure
#17
Shahryar M Chowdhury, Eric M Graham, Andrew M Atz, Scott M Bradley, Minoo N Kavarana, Ryan J Butts
The ability to quantify patient-specific hospital mortality risk before the Norwood procedure remains elusive. This study aimed to develop an accurate and clinically feasible score to assess the risk of hospital mortality in neonates undergoing the Norwood procedure. All patients (n = 549) in the publically available Pediatric Heart Network Single Ventricle Reconstruction trial database were included in the analysis. Patients were randomly divided into a derivation (75%) and validation (25%) cohort. Preoperative factors found to be associated with mortality upon univariable analysis (P < 0...
July 2016: Seminars in Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/28040565/structure-prediction-and-network-analysis-of-chitinases-from-the-cape-sundew-drosera-capensis
#18
Megha H Unhelkar, Vy T Duong, Kaosoluchi N Enendu, John E Kelly, Seemal Tahir, Carter T Butts, Rachel W Martin
BACKGROUND: Carnivorous plants possess diverse sets of enzymes with novel functionalities applicable to biotechnology, proteomics, and bioanalytical research. Chitinases constitute an important class of such enzymes, with future applications including human-safe antifungal agents and pesticides. Here, we compare chitinases from the genome of the carnivorous plant Drosera capensis to those from related carnivorous plants and model organisms. METHODS: Using comparative modeling, in silico maturation, and molecular dynamics simulation, we produce models of the mature enzymes in aqueous solution...
December 28, 2016: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28028466/consumption-of-antimicrobial-manuka-honey-does-not-significantly-perturb-the-microbiota-in-the-hind-gut-of-mice
#19
Doug Rosendale, Christine A Butts, Cloe Erika de Guzman, Ian S Maddox, Sheridan Martell, Lynn McIntyre, Margot A Skinner, Hannah Dinnan, Juliet Ansell
The aim of this study was to test the hypothesis that consuming manuka honey, which contains antimicrobial methylglyoxal, may affect the gut microbiota. We undertook a mouse feeding study to investigate whether dietary manuka honey supplementation altered microbial numbers and their production of organic acid products from carbohydrate fermentation, which are markers of gut microbiota function. The caecum of C57BL/6 mice fed a diet supplemented with antimicrobial UMF® 20+ manuka honey at 2.2 g/kg animal did not show any significantly changed concentrations of microbial short chain fatty acids as measured by gas chromatography, except for increased formate and lowered succinate organic acid concentrations, compared to mice fed a control diet...
2016: PeerJ
https://www.readbyqxmd.com/read/28024105/assessing-and-managing-multiple-risks-in-a-changing-world-the-roskilde-recommendations
#20
Henriette Selck, Peter B Adamsen, Thomas Backhaus, Gary T Banta, Peter K H Bruce, G Allen Burton, Michael B Butts, Eva Boegh, John J Clague, Khuong V Dinh, Neelke Doorn, Jonas S Gunnarsson, Henrik Hauggaard-Nielsen, Charles Hazlerigg, Agnieszka D Hunka, John Jensen, Yan Lin, Susana Loureiro, Simona Miraglia, Wayne R Munns, Farrokh Nadim, Annemette Palmqvist, Robert A Rämö, Lauren P Seaby, Kristian Syberg, Stine R Tangaa, Amalie Thit, Ronja Windfeld, Maciej Zalewski, Peter M Chapman
Roskilde University (Denmark) hosted a November 2015 workshop, Environmental Risk-Assessing and Managing Multiple Risks in a Changing World. This Focus article presents the consensus recommendations of 30 attendees from 9 countries regarding implementation of a common currency (ecosystem services) for holistic environmental risk assessment and management; improvements to risk assessment and management in a complex, human-modified, and changing world; appropriate development of protection goals in a 2-stage process; dealing with societal issues; risk-management information needs; conducting risk assessment of risk management; and development of adaptive and flexible regulatory systems...
January 2017: Environmental Toxicology and Chemistry
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