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https://www.readbyqxmd.com/read/28806748/temperature-effects-on-gene-expression-and-morphological-development-of-european-eel-anguilla-anguilla-larvae
#1
Sebastian N Politis, David Mazurais, Arianna Servili, Jose-Luis Zambonino-Infante, Joanna J Miest, Sune R Sørensen, Jonna Tomkiewicz, Ian A E Butts
Temperature is important for optimization of rearing conditions in aquaculture, especially during the critical early life history stages of fish. Here, we experimentally investigated the impact of temperature (16, 18, 20, 22 and 24°C) on thermally induced phenotypic variability, from larval hatch to first-feeding, and the linked expression of targeted genes [heat shock proteins (hsp), growth hormone (gh) and insulin-like growth factors (igf)] associated to larval performance of European eel, Anguilla anguilla...
2017: PloS One
https://www.readbyqxmd.com/read/28806337/the-sound-quality-of-cochlear-implants-studies-with-single-sided-deaf-patients
#2
Michael F Dorman, Sarah Cook Natale, Austin M Butts, Daniel M Zeitler, Matthew L Carlson
OBJECTIVE: The goal of the present study was to assess the sound quality of a cochlear implant for single-sided deaf (SSD) patients fit with a cochlear implant (CI). BACKGROUND: One of the fundamental, unanswered questions in CI research is "what does an implant sound like?" Conventional CI patients must use the memory of a clean signal, often decades old, to judge the sound quality of their CIs. In contrast, SSD-CI patients can rate the similarity of a clean signal presented to the CI ear and candidate, CI-like signals presented to the ear with normal hearing...
September 2017: Otology & Neurotology
https://www.readbyqxmd.com/read/28800483/assessment-of-aod-variability-over-saudi-arabia-using-modis-deep-blue-products
#3
Mohsin Jamil Butt, Mazen Ebraheem Assiri, Md Arfan Ali
The aim of this study is to investigate the variability of aerosol over The Kingdom of Saudi Arabia. For this analysis, Moderate Resolution Imaging Spectroradiometer (MODIS) Deep Blue (DB) Aerosol Optical Depth (AOD) product from Terra and Aqua satellites for the years 2000-2013 is used. The product is validated using AERONET data from ground stations, which are situated at Solar Village Riyadh and King Abdullah University of Science and Technology (KAUST) Jeddah. The results show that both Terra and Aqua satellites exhibit a tendency to show the spatial variation of AOD with Aqua being better than Terra to represent the ground based AOD measurements over the study region...
August 8, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28798028/ptpn2-regulates-t-cell-lineage-commitment-and-%C3%AE-%C3%AE-versus-%C3%AE-%C3%AE-specification
#4
Florian Wiede, Jarrod A Dudakov, Kun-Hui Lu, Garron T Dodd, Tariq Butt, Dale I Godfrey, Andreas Strasser, Richard L Boyd, Tony Tiganis
In the thymus, hematopoietic progenitors commit to the T cell lineage and undergo sequential differentiation to generate diverse T cell subsets, including major histocompatibility complex (MHC)-restricted αβ T cell receptor (TCR) T cells and non-MHC-restricted γδ TCR T cells. The factors controlling precursor commitment and their subsequent maturation and specification into αβ TCR versus γδ TCR T cells remain unclear. Here, we show that the tyrosine phosphatase PTPN2 attenuates STAT5 (signal transducer and activator of transcription 5) signaling to regulate T cell lineage commitment and SRC family kinase LCK and STAT5 signaling to regulate αβ TCR versus γδ TCR T cell development...
August 10, 2017: Journal of Experimental Medicine
https://www.readbyqxmd.com/read/28783691/characterization-of-t-and-b-cell-repertoire-diversity-in-patients-with-rag-deficiency
#5
Yu Nee Lee, Francesco Frugoni, Kerry Dobbs, Irit Tirosh, Likun Du, Francesca A Ververs, Heng Ru, Lisa Ott de Bruin, Mehdi Adeli, Jacob H Bleesing, David Buchbinder, Manish J Butte, Caterina Cancrini, Karin Chen, Sharon Choo, Reem A Elfeky, Andrea Finocchi, Ramsay L Fuleihan, Andrew R Gennery, Dalia H El-Ghoneimy, Lauren A Henderson, Waleed Al-Herz, Elham Hossny, Robert P Nelson, Sung-Yun Pai, Niraj C Patel, Shereen M Reda, Pere Soler-Palacin, Raz Somech, Paolo Palma, Hao Wu, Silvia Giliani, Jolan E Walter, Luigi D Notarangelo
Recombination-activating genes 1 and 2 (RAG1 and RAG2) play a critical role in T and B cell development by initiating the recombination process that controls the expression of T cell receptor (TCR) and immunoglobulin genes. Mutations in the RAG1 and RAG2 genes in humans cause a broad spectrum of phenotypes, including severe combined immunodeficiency (SCID) with lack of T and B cells, Omenn syndrome, leaky SCID, and combined immunodeficiency with granulomas or autoimmunity (CID-G/AI). Using next-generation sequencing, we analyzed the TCR and B cell receptor (BCR) repertoire in 12 patients with RAG mutations presenting with Omenn syndrome (n = 5), leaky SCID (n = 3), or CID-G/AI (n = 4)...
December 16, 2016: Science Immunology
https://www.readbyqxmd.com/read/28775156/the-sharpin-interactome-reveals-a-role-for-sharpin-in-lamellipodium-formation-via-the-arp2-3-complex
#6
Meraj H Khan, Siiri I Salomaa, Guillaume Jacquemet, Umar Butt, Mitro Miihkinen, Takahiro Deguchi, Elena Kremneva, Pekka Lappalainen, Martin J Humphries, Jeroen Pouwels
Sharpin, a multifunctional adaptor protein, regulates several signalling pathways. For example, Sharpin enhances signal-induced NF-κB signalling as part of the linear ubiquitin assembly complex (LUBAC) and inhibits integrins, the T cell receptor, caspase1 and PTEN. However, despite recent insights into Sharpin and LUBAC function, a systematic approach to identify signalling pathways regulated by Sharpin has not been reported. Here, we present the first 'Sharpin interactome', which identifies a large amount of novel potential Sharpin interactors in addition to several known ones...
August 3, 2017: Journal of Cell Science
https://www.readbyqxmd.com/read/28774035/prediction-of-the-vickers-microhardness-and-ultimate-tensile-strength-of-aa5754-h111-friction-stir-welding-butt-joints-using-artificial-neural-network
#7
Luigi Alberto Ciro De Filippis, Livia Maria Serio, Francesco Facchini, Giovanni Mummolo, Antonio Domenico Ludovico
A simulation model was developed for the monitoring, controlling and optimization of the Friction Stir Welding (FSW) process. This approach, using the FSW technique, allows identifying the correlation between the process parameters (input variable) and the mechanical properties (output responses) of the welded AA5754 H111 aluminum plates. The optimization of technological parameters is a basic requirement for increasing the seam quality, since it promotes a stable and defect-free process. Both the tool rotation and the travel speed, the position of the samples extracted from the weld bead and the thermal data, detected with thermographic techniques for on-line control of the joints, were varied to build the experimental plans...
November 10, 2016: Materials
https://www.readbyqxmd.com/read/28772138/exposure-to-flame-retardant-chemicals-and-occurrence-and-severity-of-papillary-thyroid-cancer-a-case-control-study
#8
Kate Hoffman, Amelia Lorenzo, Craig M Butt, Stephanie C Hammel, Brittany Bohinc Henderson, Sanziana A Roman, Randall P Scheri, Heather M Stapleton, Julie Ann Sosa
BACKGROUND: Thyroid cancer is the fastest increasing cancer in the U.S., and papillary thyroid cancer (PTC) accounts for >80% of incident cases. Increasing exposure to flame retardant chemicals (FRs) has raised concerns about their possible role in this 'epidemic'. The current study was designed to test the hypothesis that higher exposure to FRs is associated with increased odds of PTC. METHODS: PTC patients at the Duke Cancer Institute were approached and invited to participate...
July 31, 2017: Environment International
https://www.readbyqxmd.com/read/28771609/deletion-of-batf3-dependent-antigen-presenting-cells-does-not-affect-atherosclerotic-lesion-formation-in-mice
#9
Jesus Gil-Pulido, Clement Cochain, Malte A Lippert, Nicole Schneider, Elke Butt, Núria Amézaga, Alma Zernecke
Atherosclerosis is the main underlying cause for cardiovascular events such as myocardial infarction and stroke and its development might be influenced by immune cells. Dendritic cells (DCs) bridge innate and adaptive immune responses by presenting antigens to T cells and releasing a variety of cytokines. Several subsets of DCs can be discriminated that engage specific transcriptional pathways for their development. Basic leucine zipper transcription factor ATF-like 3 (Batf3) is required for the development of classical CD8α+ and CD103+ DCs...
2017: PloS One
https://www.readbyqxmd.com/read/28770883/cytogenetic-bio-monitoring-in-fuel-station-attendants-of-gujrat-pakistan-through-buccal-micronucleus-cytome-assay
#10
Faiza Butt, Kausar Cheema, Numrah Nisar, Javed Qureshi
OBJECTIVE: To analyse buccal epithelial cells for scoring the frequency of cytogenetic toxicity in petrol pump workers. METHODS: The case-control study was conducted at the Lahore College for Women University, Lahore, Pakistan, from September 2014 to February 2015, and comprised petrol pump workers. Buccal micronucleus cytome assay was carried out by the collection of buccal cells after the written and oral consent of petrol pump workers. Frequencies of genotoxic (micronucleated and binucleated) and cytotoxic (karryorhetic and karyolitic) cells were scored and compared with the control group...
July 2017: JPMA. the Journal of the Pakistan Medical Association
https://www.readbyqxmd.com/read/28769703/two-new-species-of-fluminicola-caenogastropoda-lithoglyphidae-from-southwest-oregon-usa-and-a-range-extension-for-f-multifarius
#11
Robert Hershler, Hsiu-Ping Liu, Niko Hubbart
We describe two new species of pebblesnails (Lithoglyphidae: Fluminicola) from southwest Oregon based on morphologic and mitochondrial DNA (COI, cytB) evidence. Fluminicola umpquaensissp. n., which had been traditionally identified as F. virens prior to the recent restriction of the latter to the lower Columbia River drainage, lives in lotic habitats in the Umpqua River basin. This species is readily distinguished from closely related F. gustafsoni and F. virens by shell and anatomical characters, and by its mtDNA sequences (divergence >3...
2017: ZooKeys
https://www.readbyqxmd.com/read/28768230/thermal-stress-analysis-of-ceramic-laminate-veneer-restorations-with-different-incisal-preparations-using-micro-computed-tomography-based-3d-finite-element-models
#12
Alper Tunga Celebi, Esra Icer, Meltem Mert Eren, Cengiz Baykasoglu, Ata Mugan, Esra Yildiz
Main objective of this study is to investigate the thermal behavior of ceramic laminate veneer restorations of the maxillary central incisor with different incisal preparations such as butt joint and palatinal chamfer using finite element method. In addition, it is also aimed to understand the effect of different thermal loads which simulates hot and cold liquid imbibing in the mouth. Three-dimensional solid models of the sound tooth and prepared veneer restorations were obtained using micro-computed tomography images...
July 27, 2017: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/28763709/similar-mechanisms-of-traumatic-rectal-injuries-in-patients-who-had-anal-sex-with-animals-to-those-who-were-butt-fisted-by-human-sexual-partner
#13
Damian Jacob Sendler
Sexual pleasure comes in various forms of physical play, for many it involves stimulation of the vagina, while the anus for others; some enjoy both. A recent report by Cappelletti et al.(1) shows a meta-analysis of cases describing anal trauma due to sexual fisting in human partners. This clinical article reports four cases of males diagnosed with zoophilia, and who received anal sex from animals, resulting in injuries. Surgical and psychiatric evaluations are summarized. Unusual etiology of sexual activity with animals caused peri-anal trauma in men who engaged in anal sex with dogs and farm animals...
July 25, 2017: Journal of Forensic and Legal Medicine
https://www.readbyqxmd.com/read/28758370/validity-of-the-remote-food-photography-method-against-doubly-labeled-water-among-minority-preschoolers
#14
Theresa Nicklas, Rabab Saab, Noemi G Islam, William Wong, Nancy Butte, Rebecca Schulin, Yan Liu, John W Apolzan, Candice A Myers, Corby K Martin
OBJECTIVE: The aim of this study was to determine the validity of energy intake (EI) estimations made using the remote food photography method (RFPM) compared to the doubly labeled water (DLW) method in minority preschool children in a free-living environment. METHODS: Seven days of food intake and spot urine samples excluding first void collections for DLW analysis were obtained on thirty-nine 3- to 5-year-old Hispanic and African American children. Using an iPhone, caregivers captured before and after pictures of each child's intake, pictures were wirelessly transmitted to trained raters who estimated portion size using existing visual estimation procedures, and energy and macronutrients were calculated...
July 31, 2017: Obesity
https://www.readbyqxmd.com/read/28752570/a-preliminary-comparison-of-two-dimensional-speckle-tracking-echocardiography-and-pressure-volume-loop-analysis-in-patients-with-fontan-physiology-the-role-of-ventricular-morphology
#15
David Steflik, Ryan J Butts, George H Baker, Varsha Bandisode, Andrew Savage, Andrew M Atz, Shahryar M Chowdhury
OBJECTIVE: Speckle tracking echocardiography (STE) may be a useful modality for assessing ventricular performance in patients with single ventricle physiology. However, STE's ability to accurately assess ventricular performance in this population is unknown. The objective of this study was to perform a preliminary comparison of STE measures of myocardial deformation to reference standard measures of function derived from pressure-volume loop (PVL) analysis. DESIGN: This was a secondary analysis of a prospective study investigating PVLs in patients with Fontan physiology...
July 28, 2017: Echocardiography
https://www.readbyqxmd.com/read/28750962/conservative-management-of-temporomandibular-dysfunction-a-literature-review-with-implications-for-clinical-practice-guidelines-narrative-review-part-2
#16
REVIEW
Raymond Butts, James Dunning, Ron Pavkovich, Jersey Mettille, Firas Mourad
The effective management of temporomandibular dysfunction (TMD) requires a thorough understanding of the pathoanatomic factors that drive the underlying condition. After reviewing the etiology associated with TMD in Part 1 of this narrative review, the temporomandibular joint capsule, articular disc and muscles of mastication emerged as key players. (http://dx.doi.org/10.​1016/​j.​jbmt.​2017.​05.​017) Part 2 focuses on conservative treatment strategies best able to reduce the pain and disability associated with TMD...
July 2017: Journal of Bodywork and Movement Therapies
https://www.readbyqxmd.com/read/28750961/pathoanatomical-characteristics-of-temporomandibular-dysfunction-where-do-we-stand-narrative-review-part-1
#17
REVIEW
Raymond Butts, James Dunning, Thomas Perreault, Jersey Mettille, James Escaloni
Temporomandibular dysfunction (TMD) is a complicated and multifactorial condition that affects the temporomandibular joint (TMJ) and muscles of mastication, resulting in pain and disability in 5-12% of the population. The condition involves genetic, anatomic and hormonal factors and is propagated, in part, by trauma, habitual activity, psychosocial components and occlusal variation. Yet, the exact etiology of TMD is still unknown and the most strategic conservative management of the condition is still a topic of debate...
July 2017: Journal of Bodywork and Movement Therapies
https://www.readbyqxmd.com/read/28750223/associations-between-flame-retardant-applications-in-furniture-foam-house-dust-levels-and-residents-serum-levels
#18
Stephanie C Hammel, Kate Hoffman, Amelia M Lorenzo, Albert Chen, Allison L Phillips, Craig M Butt, Julie Ann Sosa, Thomas F Webster, Heather M Stapleton
Polyurethane foam (PUF) in upholstered furniture frequently is treated with flame retardant chemicals (FRs) to reduce its flammability and adhere to rigorous flammability standards. For decades, a commercial mixture of polybrominated diphenyl ethers (PBDEs) called PentaBDE was commonly applied to foam to fulfill these regulations; however, concerns over toxicity, bioaccumulation, and persistence led to a global phase-out in the mid-2000s. Although PentaBDE is still detected in older furniture, other FR compounds such as tris(1,3-dichloroisopropyl) phosphate (TDCIPP) and Firemaster® 550 (FM550) have been increasingly used as replacements...
July 24, 2017: Environment International
https://www.readbyqxmd.com/read/28748934/synergy-of-synthesis-computation-and-nmr-reveals-correct-baulamycin-structures
#19
Jingjing Wu, Paula Lorenzo, Siying Zhong, Muhammad Ali, Craig P Butts, Eddie L Myers, Varinder K Aggarwal
Small-molecule, biologically active natural products continue to be our most rewarding source of, and inspiration for, new medicines. Sometimes we happen upon such molecules in minute quantities in unique, difficult-to-reach, and often fleeting environments, perhaps never to be discovered again. In these cases, determining the structure of a molecule-including assigning its relative and absolute configurations-is paramount, enabling one to understand its biological activity. Molecules that comprise stereochemically complex acyclic and conformationally flexible carbon chains make such a task extremely challenging...
July 26, 2017: Nature
https://www.readbyqxmd.com/read/28740287/evaluating-the-antimicrobial-potential-of-green-cardamom-essential-oil-focusing-on-quorum-sensing-inhibition-of-chromobacterium-violaceum
#20
Abdullah, Ali Asghar, Masood Sadiq Butt, Muhammad Shahid, Qingrong Huang
Spices are well known for their taste and flavor imparting properties. Green cardamom (Elletaria cardamomum), a herb spice belongs to family Zingiberaceae. In current study, GC-MS analysis of green cardamom essential oil (CEO) resulted in identification of twenty-six compounds with α-terpinyl acetate (38.4%), 1,8-cineole (28.71%), linalool acetate (8.42%), sabinene (5.21%), and linalool (3.97%) as major bioactive components. Present study also described the antimicrobial properties like zone of inhibition, minimum inhibitory concentration against microbial strains with special emphasis on quorum sensing inhibition...
July 2017: Journal of Food Science and Technology
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