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https://www.readbyqxmd.com/read/28342325/development-of-a-rapid-matrix-digestion-technique-for-ultrastructural-analysis-of-elastic-fibers-in-the-intervertebral-disc
#1
Javad Tavakoli, John J Costi
Collagen and elastic fibers are two major fibrous constituents of the annulus fibrosus (AF) in the disc that contribute to its mechanical and viscoelastic properties. It was thought that elastic fibers play no substantial role in the function and properties of the disc as these fibers were irregularly distributed. Studies that have revealed highly organized elastic fibers with different regional orientation and distribution, while being strongly crosslinked with matrix, suggesting their contribution to disc structure-function properties...
March 21, 2017: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/28340364/cervical-facet-force-analysis-after-disc-replacement-versus-fusion
#2
Vikas V Patel, Zachary R Wuthrich, Kirk C McGilvray, Matthew C Lafleur, Emily M Lindley, Derrick Sun, Christian M Puttlitz
BACKGROUND: Cervical total disc replacement was developed to preserve motion and reduce adjacent-level degeneration relative to fusion, yet concerns remain that total disc replacement will lead to altered facet joint loading and long-term facet joint arthrosis. This study is intended to evaluate changes in facet contact force, pressure and surface area at the treated and superior adjacent levels before and after discectomy, disc replacement, and fusion. METHODS: Ten fresh-frozen human cadaveric cervical spines were potted from C2 to C7 with pressure sensors placed into the facet joints of C3-C4 and C4-C5 via slits in the facet capsules...
March 18, 2017: Clinical Biomechanics
https://www.readbyqxmd.com/read/28337733/bias-in-cervical-total-disc-replacement-trials
#3
REVIEW
Kristen Radcliff, Sean Siburn, Hamadi Murphy, Barrett Woods, Sheeraz Qureshi
PURPOSE OF REVIEW: Cervical disc replacement (CDR) has emerged as a motion-preserving alternative to anterior cervical discectomy and fusion in selected cases. Despite favorable literature, CDR is not universally accepted because of concerns regarding bias in the existing literature. The purpose of this review is to identify the possible biases in the disc replacement literature. RECENT FINDINGS: Recent studies that compare CDR and ACDF have demonstrated equivalent or superior outcomes, lower rates of secondary surgery, and equivalent safety at medium- and long-term follow-up...
March 23, 2017: Current Reviews in Musculoskeletal Medicine
https://www.readbyqxmd.com/read/28337729/adjacent-level-disease-background-and-update-based-on-disc-replacement-data
#4
REVIEW
I David Kaye, Alan S Hilibrand
PURPOSE OF REVIEW: The precise etiology of adjacent segment disease following cervical spine surgery is controversial. Theories for development include inevitable changes secondary to the natural progression of the degenerative cascade and changes secondary to altered biomechanics of the fused cervical spine. Motion preserving techniques, such as cervical disc arthroplasties (CDA), have been introduced with the hopes of reducing the rates of adjacent segment pathology. Recently, 7-year data from the investigational device exemption (IDE) studies have been published...
March 23, 2017: Current Reviews in Musculoskeletal Medicine
https://www.readbyqxmd.com/read/28326305/implications-for-a-stem-cell-regenerative-medicine-based-approach-to-human-intervertebral-disk-degeneration
#5
REVIEW
Petra Kraus, Thomas Lufkin
The human body develops from a single cell, the zygote, the product of the maternal oocyte and the paternal spermatozoon. That 1-cell zygote embryo will divide and eventually grow into an adult human which is comprised of ~3.7 × 10(13) cells. The tens of trillions of cells in the adult human can be classified into approximately 200 different highly specialized cell types that make up all of the different tissues and organs of the human body. Regenerative medicine aims to replace or restore dysfunctional cells, tissues and organs with fully functional ones...
2017: Frontiers in Cell and Developmental Biology
https://www.readbyqxmd.com/read/28324327/lumbar-disc-replacement-surgery-successes-and-obstacles-to-widespread-adoption
#6
REVIEW
Stephan N Salzmann, Nicolas Plais, Jennifer Shue, Federico P Girardi
PURPOSE OF REVIEW: Lumbar disc replacement has been a surgical alternative to fusion surgery for the treatment of lumbar degenerative disc disease (DDD) for many years. Despite enthusiasm after the approval of the first devices, implantation rates have remained low, especially in the USA. The goal of this review is to provide a general overview of lumbar disc replacement in order to comprehend the successes and obstacles to widespread adoption. RECENT FINDINGS: Although a large amount of evidence-based data including satisfactory long-term results is available, implantation rates in the USA have not increased in the last decade...
March 21, 2017: Current Reviews in Musculoskeletal Medicine
https://www.readbyqxmd.com/read/28288337/remodelling-of-myocardial-intercalated-disc-protein-connexin-43-causes-increased-susceptibility-to-malignant-arrhythmias-in-arvc-d-patients
#7
Xiao Chen, Liang Chen, Zhenglian Chen, Xinshan Chen, Jiangping Song
BACKGROUND: Arrhythmogenic right ventricular cardiomyopathy/dysplasia (ARVC/D) is a primary cardiomyopathy characterised by fibrofatty replacement and ventricular arrhythmias. The occurrence of malignant arrhythmias may be associated with fatty infiltration and intercalated disk remodelling, but the specific pathological remodelling pattern is not yet clear. METHODS: Twelve explanted hearts from patients diagnosed with ARVC/D according to the 2010 Task Force Criteria and pathology examination were divided into two groups with (SVT, n=6) or without (non-SVT, n=6) recurrent sustained ventricular tachycardia (SVT) before heart transplantation...
February 27, 2017: Forensic Science International
https://www.readbyqxmd.com/read/28279049/-displacement-and-tissue-remodeling-of-temporomandibular-joint-disc
#8
M Q Wang
Sounding takes the highest prevalence of the signs of temporomandibular disorders (TMD). The well accepted theory of the mechanism for temporomandibular joint (TMJ) sounding is the internal derangement typically characterized by disc displacement. However, according to literature, there are approximately one third of asymptomatic joints in population had disc displacement, and, on the other hand, there are one fourth of TMJ sounding patients had not signs or very limited signs of disc displacement. Replacing the displaced disc to the normal position via methods like surgical operation did not achieve satisfactory long-term outcomes...
March 9, 2017: Zhonghua Kou Qiang Yi Xue za Zhi, Zhonghua Kouqiang Yixue Zazhi, Chinese Journal of Stomatology
https://www.readbyqxmd.com/read/28261429/radiological-parameters-of-undegenerated-cervical-vertebral-segments-in-a-korean-population
#9
Sung Hoon Choi, HeeSang Lee, Jae Hwan Cho, Jin Il Jung, Dong-Ho Lee
BACKGROUND: Several scoring systems for cervical disc and facet joint degeneration, using radiography or computed tomography, have been developed and tested for reliability. However, definitions of disc height and facet joint space narrowing vary. To our knowledge, no study has reported quantitative data for normal radiologic values of the cervical spine in the Korean population. The purpose of this study is to determine normal cervical disc height, disc height ratio, and facet joint space values, and investigate the correlation between demographic data and these values...
March 2017: Clinics in Orthopedic Surgery
https://www.readbyqxmd.com/read/28254733/bioengineered-temporomandibular-joint-disk-implants-study-protocol-for-a-two-phase-exploratory-randomized-preclinical-pilot-trial-in-18-black-merino-sheep-tempojims
#10
David Faustino Ângelo, Florencio Gil Monje, Raúl González-García, Christopher B Little, Lisete Mónico, Mário Pinho, Fábio Abade Santos, Belmira Carrapiço, Sandra Cavaco Gonçalves, Pedro Morouço, Nuno Alves, Carla Moura, Yadong Wang, Eric Jeffries, Jin Gao, Rita Sousa, Lia Lucas Neto, Daniel Caldeira, Francisco Salvado
BACKGROUND: Preclinical trials are essential to test efficacious options to substitute the temporomandibular joint (TMJ) disk. The contemporary absence of an ideal treatment for patients with severe TMJ disorders can be related to difficulties concerning the appropriate study design to conduct preclinical trials in the TMJ field. These difficulties can be associated with the use of heterogeneous animal models, the use of the contralateral TMJ as control, the absence of rigorous randomized controlled preclinical trials with blinded outcomes assessors, and difficulties involving multidisciplinary teams...
March 2, 2017: JMIR Research Protocols
https://www.readbyqxmd.com/read/28254671/are-patient-reported-outcomes-predictive-of-patient-satisfaction-5-years-after-anterior-cervical-spine-surgery
#11
Gregory D Schroeder, Dom Coric, Han Jo Kim, Todd J Albert, Kris E Radcliff
BACKGROUND CONTEXT: Patient satisfaction is becoming an increasing common proxy for surgical quality; however, the correlation between patient satisfaction and surgical outcomes 2 and 5 years after anterior cervical surgery has not been evaluated. PURPOSE: The study aimed to determine if patient satisfaction is predicted by improvement in patient-reported outcomes (PRO) 2 and 5 years after anterior cervical spine surgery. STUDY DESIGN: This is a retrospective analysis of prospectively collected data...
February 27, 2017: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/28250637/analysis-of-the-spinal-nerve-roots-in-relation-to-the-adjacent-vertebral-bodies-with-respect-to-a-posterolateral-vertebral-body-replacement-procedure
#12
Waleed Awwad, Jonathan Bourget-Murray, Nadil Zeiadin, Juan P Mejia, Thomas Steffen, Abdulrahman D Algarni, Khalid Alsaleh, Jean Ouellet, Michael Weber, Peter F Jarzem
OBJECTIVE: This study aims to improve the understanding of the anatomic variations along the thoracic and lumbar spine encountered during an all-posterior vertebrectomy, and reconstruction procedure. This information will help improve our understanding of human spine anatomy and will allow better planning for a vertebral body replacement (VBR) through either a transpedicular or costotransversectomy approach. SUMMARY OF BACKGROUND DATA: The major challenge to a total posterior approach vertebrectomy and VBR in the thoracolumbar spine lies in the preservation of important neural structures...
January 2017: Journal of Craniovertebral Junction and Spine
https://www.readbyqxmd.com/read/28215460/early-experience-with-lateral-lumbar-total-disc-replacement-utility-complications-and-revision-strategies
#13
Gregory M Malham, Rhiannon M Parker
Lumbar total disc replacement (TDR) is an alternative to interbody fusion for the treatment of symptomatic degenerative disc disease. Traditionally, lumbar TDR is performed via an anterior retroperitoneal approach with regional risks of vascular and visceral injury. The direct lateral retroperitoneal, transpsoas approach avoids mobilisation of the great vessels and preserves the anterior longitudinal ligament, thereby maintaining physiological limits on motion. This study aimed to (i) report one site's early experience with lateral lumbar TDR and (ii) provide case examples illustrating the utility, complications and revision strategies of the XL-TDR device...
February 16, 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/28210626/osteogenic-differentiation-capacity-of-in-vitro-cultured-human-skeletal-muscle-for-expedited-bone-tissue-engineering
#14
Chunlei Miao, Lulu Zhou, Lufeng Tian, Yingjie Zhang, Wei Zhang, Fanghong Yang, Tianyi Liu, Shengjian Tang, Fangjun Liu
Expedited bone tissue engineering employs the biological stimuli to harness the intrinsic regenerative potential of skeletal muscle to trigger the reparative process in situ to improve or replace biological functions. When genetically modified with adenovirus mediated BMP2 gene transfer, muscle biopsies from animals have demonstrated success in regenerating bone within rat bony defects. However, it is uncertain whether the human adult skeletal muscle displays an osteogenic potential in vitro when a suitable biological trigger is applied...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28198781/biomechanical-analysis-of-two-level-cervical-disc-replacement-with-a-stand-alone-u-shaped-disc-implant
#15
Yang Li, Guy R Fogel, Zhenhua Liao, Rajnesh Tyagi, Gaolong Zhang, Weiqiang Liu
STUDY DESIGN: Biomechanical study using a three-dimensional nonlinear finite element (FE) model. OBJECTIVE: To analyze biomechanical changes with three prostheses based on two-level arthroplasty and to verify the biomechanical efficiency of dynamic cervical implants (DCIs) with a stand-alone U-shaped structure. SUMMARY OF BACKGROUND DATA: Few studies have compared biomechanical behavior of various prostheses as they relate to clinical results after two-level total disc replacement (TDR)...
February 14, 2017: Spine
https://www.readbyqxmd.com/read/28183604/wear-behaviour-of-uhmwpe-reinforced-by-carbon-nanofiller-and-paraffin-oil-for-joint-replacement
#16
Samy Yousef, Annamaria Visco, Giovanna Galtieri, Davide Nocita, Claudia Espro
The majority of artificial joints incorporate biomedical grade Ultra High Molecular Weight Poly Ethylene (UHMWPE), whose wear is considered most important in controlling service time of the whole joint. The aim of this work was to improve wear resistance of UHMWPE through the addition of 0.5-2.0wt% of Carbon Nano Filler (CNF) and 2% wt of Paraffin Oil (PO) using ball milling (BM) and extrusion techniques (EX). The wear tests on these nanocomposites were conducted by a pin on disc in dry (air) and wet media (simulated synovial fluid or artificial lubricant, and bovine synovial fluid or natural lubricant)...
April 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28178135/durability-of-cervical-disc-arthroplasties-and-its-influence-factors-a-systematic-review-and-a-network-meta-analysis
#17
REVIEW
Chao Chen, Xiaolin Zhang, Xinlong Ma
BACKGROUND: The durability of cervical disc arthroplasties (CDA) may vary significantly because of different designs and implanting techniques of the devices. Nevertheless, the comparative durability remains unknown. OBJECTIVES: We aimed to assess the durability of CDAs in at least 2-year follow-up. We analyzed the classifications and causes of secondary surgical procedures, as well as the structural designs of the devices that might influence the durability. METHODS: PubMed, Medline, Embase, and Cochrane Central Register of Controlled Trials were searched from the inception of each database to September 2015 using the following Keywords: "cervical disc replacement" OR "cervical disc arthroplasty" AND "randomized controlled trial (RCT)...
February 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28175530/342%C3%A2-lumbar-total-disc-replacement-by-the-lateral-approach-up-to-10-year-follow-up
#18
Luiz Pimenta, Luis Marchi, Rodrigo Augusto Amaral, Leonardo Oliveira, Joes Nogueira-Neto, Rubens Jensen, Etevaldo Coutinho
No abstract text is available yet for this article.
August 1, 2016: Neurosurgery
https://www.readbyqxmd.com/read/28175519/345%C3%A2-elective-anterior-cervical-discectomy-and-fusion-vs-cervical-artificial-disc-replacement-a-comparison-of-perioperative-morbidity-and-early-outcomes
#19
Pavan S Upadhyayula, John K Yue, Reid Hoshide, Erik Curtis, Joseph D Ciacci
No abstract text is available yet for this article.
August 1, 2016: Neurosurgery
https://www.readbyqxmd.com/read/28142281/adjacent-level-arthroplasty-following-cervical-fusion
#20
Deshpande V Rajakumar, Akshay Hari, Murali Krishna, Subhas Konar, Ankit Sharma
OBJECTIVE Adjacent-level disc degeneration following cervical fusion has been well reported. This condition poses a major treatment dilemma when it becomes symptomatic. The potential application of cervical arthroplasty to preserve motion in the affected segment is not well documented, with few studies in the literature. The authors present their initial experience of analyzing clinical and radiological results in such patients who were treated with arthroplasty for new or persistent arm and/or neck symptoms related to neural compression due to adjacent-segment disease after anterior cervical discectomy and fusion (ACDF)...
February 2017: Neurosurgical Focus
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