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Disc replacement

Y-C Huang, J Xiao, W Y Leung, W W Lu, Y Hu, K D Luk
Previous human study suggested that fresh-frozen intervertebral disc allograft transplantation can relieve neurological symptoms and restore segmental kinematics. Before wide clinical application, research into the pathophysiology of the postoperative disc allograft is needed. One important question that remains to be answered in disc allografting is the healing process of the host-graft interface and the subsequent change of the endplates. With the goat model for lumbar disc allografting, histology, micro-computed tomography analysis, scanning electron microscopy and energy-dispersive X-ray spectroscopy mapping were applied to evaluate the healing of the host-graft interfaces, the remodelling of subchondral bone, and the changes of the bony and cartilaginous endplates after transplantation...
October 19, 2016: European Cells & Materials
Andreas Reinke, Michael Behr, Alexander Preuss, Jimmy Villard, Bernhard Meyer, Florian Ringel
OBJECT: Total disc replacement (TDR) is typically indicated in young patients with a cervical soft disc herniation. To date, there are few data on the activity level of patients after cervical TDR; in particular, from young patients who are expected to have a high activity level with frequent exercising. The expectation is that returning to active sports after cervical TDR is not restricted. METHODS: Fifty patients were treated with a monosegmental cervical TDR at our department between May 2006 and March 2012...
October 14, 2016: World Neurosurgery
Benjamin Fabian, Katharina Schneeberg, Rolf Georg Beutel
Genetically modified organisms are crucial for our understanding of gene regulatory networks, physiological processes and ontogeny. With modern molecular genetic techniques allowing the rapid generation of different Drosophila melanogaster mutants, efficient in-depth morphological investigations become an important issue. Anatomical studies can elucidate the role of certain genes in developmental processes and point out which parts of gene regulatory networks are involved in evolutionary changes of morphological structures...
October 6, 2016: Arthropod Structure & Development
Bin Wu, Chunyang Meng, Haibin Wang, Cunling Jia, Yifeng Zhao
OBJECTIVE: Post-operation of cervical decompression fusion and internal fixation (CDF) accelerated adjacent segment disc degeneration (ASD). It is not clear that whether instability of one single segmental accelerates the degeneration of adjacent segment disc. This study aims to explore the effect of cervical instability on the change of morphology and biochemistry in adjective segment (above) in the L5/6 cervical instability rabbit models. METHODS: Thirty-two mature New Zealand white rabbits (3000±250g) were randomly divided into two groups, control group (n=8) and model group (n=24)...
October 4, 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Gauri Tendulkar, Phillip Grau, Patrick Ziegler, Alfred Buck, Alfred Buck, Andreas Badke, Hans-Peter Kaps, Sabrina Ehnert, Andreas K Nussler
Intervertebral disc degeneration and disc herniation is one of the major causes of lower back pain. Depletion of extracellular matrix, culminating in nucleus pulposus (NP) extrusion leads to intervertebral disc destruction. Currently available surgical treatments reduce the pain but do not restore the mechanical functionality of the spine. In order to preserve mechanical features of the spine, total disc or nucleus replacement thus became a wide interest. However, this arthroplasty era is still in an immature state, since none of the existing products have been clinically evaluated...
2016: Journal of Visualized Experiments: JoVE
Monish M Maharaj, Kevin Phan, Ralph J Mobbs
BACKGROUND: Patient dissatisfaction with donor site morbidity has led to the search for alternative grafting options and techniques. This report compares patient satisfaction rates between autograft and graft substitutes for anterior cervical discectomy and fusion (ACDF). METHODS: This study was performed with the approval of the local area health network ethics committee. Over a 9-year period, the author performed 574 ACDF procedures (697 levels). Of these, 22 patients had previous surgery with autograft, with a subsequent ACDF procedure performed using a graft substitute...
June 2016: J Spine Surg
Ryan Siskey, Lauren Ciccarelli, Melissa K C Lui, Steven M Kurtz
BACKGROUND: Most contemporary total disc replacements (TDRs) use conventional orthopaedic bearing couples such as ultrahigh-molecular-weight polyethylene (polyethylene) and cobalt-chromium (CoCr). Cervical total disc replacements incorporating polyetheretherketone (PEEK) bearings (specifically PEEK-on-PEEK bearings) have been previously investigated, but little is known about PEEK-on-ceramic bearings for TDR. QUESTIONS/PURPOSES: (1) What is the tribologic behavior of a PEEK-on-ceramic bearing for cervical TDR under idealized, clean wear test conditions? (2) How does the PEEK-on-ceramic design perform under impingement conditions? (3) How is the PEEK-on-ceramic bearing affected by abrasive wear? (4) Is the particle morphology from PEEK-on-ceramic bearings for TDRs affected by adverse wear scenarios? METHODS: PEEK-on-ceramic cervical TDR bearings were subjected to a 10 million cycle ideal wear test based on ASTM F2423 and ISO 181912-1 using a six-station spine wear simulator (MTS, Eden Prairie, MN, USA) with 5 g/L bovine serum concentration at 23° ± 2° C (ambient temperature)...
November 2016: Clinical Orthopaedics and related Research
Mark Moldavsky, Pavel Neumann, Noelle Klocke, Mir Hussain, Brandon S Bucklen
PURPOSE: Lateral lumbar disc prosthesis (LLDP) is an innovative device used to restore motion in select patients through a lateral retroperitoneal approach. No in vitro biomechanical studies have been published. Further, the potential for in toto circumferential joint restoration when use of this anterior disc is combined with facet replacement remains unqualified but signifies a potentially interesting clinical direction. METHODS: Researchers conducted a biomechanical feasibility study of an LLDP designed to investigate parameters of disc sizing used with bilateral facet joint replacement in a cadaveric model...
September 26, 2016: European Spine Journal
Nils Hansen-Algenstaedt, Salah Khalifah, Melanie Liem, Johannes Holz, Alf Giese
No abstract text is available yet for this article.
September 26, 2016: European Spine Journal
Elena Provaggi, Julian J H Leong, Deepak M Kalaskar
The latest and fastest-growing innovation in the medical field has been the advent of three-dimensional printing technologies, which have recently seen applications in the production of low-cost, patient-specific medical implants. While a wide range of three-dimensional printing systems has been explored in manufacturing anatomical models and devices for the medical setting, their applications are cutting-edge in the field of spinal surgery. This review aims to provide a comprehensive overview and classification of the current applications of three-dimensional printing technologies in spine care...
September 22, 2016: Proceedings of the Institution of Mechanical Engineers. Part H, Journal of Engineering in Medicine
Eric B Laxer, Craig D Brigham, Bruce V Darden, P Bradley Segebarth, R Alden Milam, Alfred L Rhyne, Susan M Odum, Leo R Spector
PURPOSE: Many investigators have reported the financial conflicts of interest (COI), which could result in potential bias in the reporting of outcomes for patients undergoing total disc replacement (TDR) rather than anterior cervical discectomy and fusion (ACDF). This bias may be subconsciously introduced by the investigator in a non-blinded radiographic review. The purpose of this study was to determine if bias was present when a group of spine specialists rated adjacent segment degeneration (ASD) following cervical TDR or ACDF...
September 20, 2016: European Spine Journal
Jose María González-Santos, María Elena Arnáiz-García, María José Dalmau-Sorlí, Jose Alfonso Sastre-Rincón, Jesús Hernández-Hernández, María Elena Pérez-Losada, Víctor Sagredo-Meneses, Javier López-Rodríguez
A patient who underwent previous implantation of a mitral valve replacement with a Björk-Shiley Delrin (BSD) mitral valve prosthesis during infancy was admitted to our institution 43 years later after an episode of syncope and cardiac arrest. Under extreme hemodynamic instability, a mitral valve prosthetic dysfunction causing massive mitral regurgitation was identified. The patient underwent an emergent cardiac operation, and a complete disc fracture with partial disc migration was found. Exceptional cases of mechanical prosthetic heart valve fracture exist...
October 2016: Annals of Thoracic Surgery
Mustafa Al Qaysi, Aviva Petrie, Rishma Shah, Jonathan C Knowles
Phosphate-based glasses have been examined in many studies as a potential biomaterial for bone repair because of its degradation properties, which can be controlled and allow the release of various elements to promote osteogenic tissue growth. However most of these experiments studied either tertiary or quaternary glass systems. This study investigated a qinternary system that included titanium dioxide for degradation rate control and zinc that is considered to have a role in bone formation. Zinc and titanium phosphate glass discs of different compositions were melt synthesized and samples of each composition was tested for different physical, chemical and biological characteristics via density measurement, X-ray diffraction, differential thermal analysis, mass loss, ion release, scanning electron microscopy, biocompatibility studies via live/dead assays at three time points (day 1, 4, and 7)...
October 2016: Journal of Materials Science. Materials in Medicine
G Briand, O Dauchot
We experimentally study the crystallization of a monolayer of vibrated discs with a built-in polar asymmetry, a model system of active liquids, and contrast it with that of vibrated isotropic discs. Increasing the packing fraction ϕ, the quasicontinuous crystallization reported for isotropic discs is replaced by a transition, or a crossover, towards a "self-melting" crystal. Starting from the liquid phase and increasing the packing fraction, clusters of dense hexagonal-ordered packed discs spontaneously form, melt, split, and merge, leading to a highly intermittent and heterogeneous dynamics...
August 26, 2016: Physical Review Letters
J D O Barceinas-Sanchez, M Alvarez-Vera, L A Montoya-Santiyanes, I Dominguez-Lopez, A L Garcia-Garcia
The observation of tribological phenomena occurring in total knee replacement (TKR) simulators may be obscured by the intrinsic complexity of their operation: the dynamics and kinematics prescribed by the ISO 14243-3:2014 standard, and the geometry of the surfaces involved. On the other hand, evaluating the individual performance of the tribosystem elements may be carried out in simpler apparatuses. An experimental method is presented here, by means of which the arthrokinematics and loading conditions prescribed by the said standard are adapted to a ball-on-disc configuration in order to observe the behavior of the coefficient of friction along an entire walking cycle, using the contact point of an AISI 316L stainless steel ball rolling/sliding on an ultra-high molecular weight polyethylene (UHMWPE) disc, lubricated by a solution of fetal bovine serum, at 37°C...
August 30, 2016: Journal of the Mechanical Behavior of Biomedical Materials
Chang-Hyun Lee, Seung-Jae Hyun, Ki-Jeong Kim, Tae-Ahn Jahng, Hyun-Jib Kim
AIM: Although conventional posterior lumbar interbody fusion (PLIF) using pedicle screws accomplish successful outcomes, pedicle screw related complications were sometimes noted. SPIRE™ was invented as interspinous fixation device (ISD) to replace pedicle screw. This study is to evaluate the clinical and radiological outcomes in patients underwent unilateral PLIF using SPIRE™ compared with pedicle screw. MATERIAL AND METHODS: All consecutive patients who shows medically intractable lumbar degenerative disease with unilateral radiculopathy and mild instability were enrolled...
November 13, 2015: Turkish Neurosurgery
DongMei He, XiuJuan Yang, FeiYu Wang, Chi Yang, MinJun Dong
Acute traumatic temporomandibular joint disc displacement (ATDD) and its sequelae are not familiar for most surgeons. This study is to discuss its sequelae in cases without disc reduction after failed conservative treatment. From 2010 to 2015, 26 patients with 34 joints were included in the study. All patients had at least 3 months conservative treatment. Their maximal incisor opening (MIO) was measured during follow-ups and MRI examination was used to check the condylar bone degeneration. The mean follow-up for conservative treatment after admission was 8...
2016: Scientific Reports
F C Bach, S A de Vries, F M Riemers, J Boere, F W van Heel, M van Doeselaar, S S Goerdaya, P G Nikkels, K Benz, L B Creemers, A F Maarten Altelaar, B P Meij, K Ito, M A Tryfonidou
During intervertebral disc (IVD) maturation, notochordal cells (NCs) are replaced by chondrocyte-like cells (CLCs) in the nucleus pulposus, suggesting that NCs play a role in maintaining tissue health. Affirmatively, NC-conditioned medium (NCCM) exerts regenerative effects on CLC proliferation and extracellular matrix (ECM) production. The aim of this study was to identify NC-secreted substances that stimulate IVD regeneration. By mass spectrometry of porcine, canine and human NCCM, 149, 170 and 217 proteins were identified, respectively, with 66 proteins in common...
2016: European Cells & Materials
Yu Chao Lee, Mario Giuseppe Tedesco Zotti, Orso Lorenzo Osti
Lumbar degenerative disc disease is extremely common. Current evidence supports surgery in carefully selected patients who have failed non-operative treatment and do not exhibit any substantial psychosocial overlay. Fusion surgery employing the correct grafting and stabilization techniques has long-term results demonstrating successful clinical outcomes. However, the best approach for fusion remains debatable. There is some evidence supporting the more complex, technically demanding and higher risk interbody fusion techniques for the younger, active patients or patients with a higher risk of non-union...
August 2016: Asian Spine Journal
Timothy M Wright
No abstract text is available yet for this article.
August 17, 2016: Clinical Orthopaedics and related Research
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