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Parkinson's Disease, Deep brain stimulation

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https://www.readbyqxmd.com/read/28334851/the-modulatory-effect-of-adaptive-deep-brain-stimulation-on-beta-bursts-in-parkinson-s-disease
#1
Gerd Tinkhauser, Alek Pogosyan, Simon Little, Martijn Beudel, Damian M Herz, Huiling Tan, Peter Brown
Adaptive deep brain stimulation uses feedback about the state of neural circuits to control stimulation rather than delivering fixed stimulation all the time, as currently performed. In patients with Parkinson's disease, elevations in beta activity (13-35 Hz) in the subthalamic nucleus have been demonstrated to correlate with clinical impairment and have provided the basis for feedback control in trials of adaptive deep brain stimulation. These pilot studies have suggested that adaptive deep brain stimulation may potentially be more effective, efficient and selective than conventional deep brain stimulation, implying mechanistic differences between the two approaches...
February 13, 2017: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/28332488/parkinson-disease
#2
REVIEW
Werner Poewe, Klaus Seppi, Caroline M Tanner, Glenda M Halliday, Patrik Brundin, Jens Volkmann, Anette-Eleonore Schrag, Anthony E Lang
Parkinson disease is the second-most common neurodegenerative disorder that affects 2-3% of the population ≥65 years of age. Neuronal loss in the substantia nigra, which causes striatal dopamine deficiency, and intracellular inclusions containing aggregates of α-synuclein are the neuropathological hallmarks of Parkinson disease. Multiple other cell types throughout the central and peripheral autonomic nervous system are also involved, probably from early disease onwards. Although clinical diagnosis relies on the presence of bradykinesia and other cardinal motor features, Parkinson disease is associated with many non-motor symptoms that add to overall disability...
March 23, 2017: Nature Reviews. Disease Primers
https://www.readbyqxmd.com/read/28331322/the-role-of-deep-brain-stimulation-in-parkinson-s-disease-an-overview-and-update-on-new-developments
#3
REVIEW
John Y Fang, Christopher Tolleson
Parkinson's disease (PD) is a progressive neurodegenerative disorder characterized by the loss of neuronal dopamine production in the brain. Oral therapies primarily augment the dopaminergic pathway. As the disease progresses, more continuous delivery of therapy is commonly needed. Deep brain stimulation (DBS) has become an effective therapy option for several different neurologic and psychiatric conditions, including PD. It currently has US Food and Drug Administration approval for PD and essential tremor, as well as a humanitarian device exception for dystonia and obsessive-compulsive disorder...
2017: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/28323092/the-effect-of-deep-brain-stimulation-of-the-subthalamic-nucleus-on-executive-functions-impaired-verbal-fluency-and-intact-updating-planning-and-conflict-resolution-in-parkinson-s-disease
#4
Gyula Demeter, István Valálik, Péter Pajkossy, Agnes Szőllősi, Ágnes Lukács, Ferenc Kemény, Mihály Racsmány
Although the improvement of motor symptoms in Parkinson's disease (PD) after Deep Brain Stimulation (DBS) of the subthalamic nucleus (STN) is well documented, there are open questions regarding its impact on cognitive functions. The aim of the present study was to assess the effect of bilateral DBS of the STN on executive functions in PD patients using a DBS wait-listed PD control group. Ten PD patients with DBS implantation (DBS group) and ten PD wait-listed patients (Clinical control group) participated in the study...
March 18, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28316456/functional-connectivity-of-the-pedunculopontine-nucleus-and-surrounding-region-in-parkinson-s-disease
#5
Ashwani Jha, Vladimir Litvak, Samu Taulu, Wesley Thevathasan, Jonathan A Hyam, Tom Foltynie, Patricia Limousin, Marko Bogdanovic, Ludvic Zrinzo, Alexander L Green, Tipu Z Aziz, Karl Friston, Peter Brown
Deep brain stimulation of the pedunculopontine nucleus and surrounding region (PPNR) is a novel treatment strategy for gait freezing in Parkinson's disease (PD). However, clinical results have been variable, in part because of the paucity of functional information that might help guide selection of the optimal surgical target. In this study, we use simultaneous magnetoencephalography and local field recordings from the PPNR in seven PD patients, to characterize functional connectivity with distant brain areas at rest...
January 2017: Cerebral Cortex
https://www.readbyqxmd.com/read/28303790/design-of-robust-adaptive-controller-and-feedback-error-learning-for-rehabilitation-in-parkinson-s-disease-a-simulation-study
#6
Korosh Rouhollahi, Mehran Emadi Andani, Seyed Mahdi Karbassi, Iman Izadi
Deep brain stimulation (DBS) is an efficient therapy to control movement disorders of Parkinson's tremor. Stimulation of one area of basal ganglia (BG) by DBS with no feedback is the prevalent opinion. Reduction of additional stimulatory signal delivered to the brain is the advantage of using feedback. This results in reduction of side effects caused by the excessive stimulation intensity. In fact, the stimulatory intensity of controllers is decreased proportional to reduction of hand tremor. The objective of this study is to design a new controller structure to decrease three indicators: (i) the hand tremor; (ii) the level of delivered stimulation in disease condition; and (iii) the ratio of the level of delivered stimulation in health condition to disease condition...
February 2017: IET Systems Biology
https://www.readbyqxmd.com/read/28303202/effects-of-deep-brain-stimulation-on-vocal-fold-immobility-in-parkinson-s-disease
#7
Elsa V Arocho-Quinones, Michael J Hammer, Jonathan M Bock, Peter A Pahapill
BACKGROUND: Vocal fold (VF) immobility is a rare, potentially fatal complication of advanced Parkinson's disease (PD). Previous reports suggest that subthalamic nucleus deep brain stimulation (STN-DBS) may influence laryngeal function, yet the role of STN-DBS on VF immobility remains unexplored. CASE DESCRIPTION: We report a case of a patient with advanced PD and bilateral VF immobility ultimately requiring a tracheostomy. To assess the effects of STN-DBS on vocal cord function and to correlate these effects with peripheral motor symptoms at different stimulation settings, the patient was evaluated before and after initiation of bilateral STN-DBS...
2017: Surgical Neurology International
https://www.readbyqxmd.com/read/28298263/a-proof-of-principle-simulation-for-closed-loop-control-based-on-preexisting-experimental-thalamic-dbs-enhanced-instrumental-learning
#8
Ching-Fu Wang, Shih-Hung Yang, Sheng-Huang Lin, Po-Chuan Chen, Yu-Chun Lo, Han-Chi Pan, Hsin-Yi Lai, Lun-De Liao, Hui-Ching Lin, Hsu-Yan Chen, Wei-Chen Huang, Wun-Jhu Huang, You-Yin Chen
Deep brain stimulation (DBS) has been applied as an effective therapy for treating Parkinson's disease or essential tremor. Several open-loop DBS control strategies have been developed for clinical experiments, but they are limited by short battery life and inefficient therapy. Therefore, many closed-loop DBS control systems have been designed to tackle these problems by automatically adjusting the stimulation parameters via feedback from neural signals, which has been reported to reduce the power consumption...
February 24, 2017: Brain Stimulation
https://www.readbyqxmd.com/read/28298033/diffusion-tractography-imaging-guided-frameless-linear-accelerator-stereotactic-radiosurgical-thalamotomy-for-tremor-case-report
#9
Won Kim, Justin Sharim, Stephen Tenn, Tania Kaprealian, Yvette Bordelon, Nzhde Agazaryan, Nader Pouratian
Essential tremor and Parkinson's disease-associated tremor are extremely prevalent within the field of movement disorders. The ventral intermediate (VIM) nucleus of the thalamus has been commonly used as both a neuromodulatory and neuroablative target for the treatment of these forms of tremor. With both deep brain stimulation and Gamma Knife radiosurgery, there is an abundance of literature regarding the surgical planning, targeting, and outcomes of these methodologies. To date, there have been no reports of frameless, linear accelerator (LINAC)-based thalomotomies for tremor...
February 24, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/28296361/-comment-on-article-deep-brain-stimulation-in-parkinson-s-disease-preliminary-results
#10
Miguel Gelabert-González, Eduardo Arán-Echabe
No abstract text is available yet for this article.
March 2017: Revista Médica del Instituto Mexicano del Seguro Social
https://www.readbyqxmd.com/read/28288201/optokinetic-nystagmus-reflects-perceptual-directions-in-the-onset-binocular-rivalry-in-parkinson-s-disease
#11
Mana Fujiwara, Catherine Ding, Lisandro Kaunitz, Julie C Stout, Dominic Thyagarajan, Naotsugu Tsuchiya
Optokinetic nystagmus (OKN), the reflexive eye movements evoked by a moving field, has recently gained interest among researchers as a useful tool to assess conscious perception. When conscious perception and stimulus are dissociated, such as in binocular rivalry-when dissimilar images are simultaneously presented to each eye and perception alternates between the two images over time-OKN correlates with perception rather than with the physical direction of the moving field. While this relationship is well established in healthy subjects, it is yet unclear whether it also generalizes to clinical populations, for example, patients with Parkinson's disease...
2017: PloS One
https://www.readbyqxmd.com/read/28285213/remote-modulation-of-network-excitability-during-deep-brain-stimulation-for-epilepsy
#12
REVIEW
Dong-Hong Li, Xiao-Feng Yang
Deep brain stimulation (DBS) has become a well-accepted medical therapy in the treatment of movement disorders such as Parkinson's disease, and is currently under investigation as a treatment for other disorders, including epilepsy. Although DBS is widely used, its therapeutic mechanisms remain poorly understood. Recent research shows that seizures are network-level phenomena, but the incomplete knowledge of neural circuit function has left a gap in our understanding of how disruption at a molecular or cellular level generates epilepsy...
March 4, 2017: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/28282816/my-25-stimulating-years-with-dbs-in-parkinson-s-disease
#13
Marwan Hariz
The year 2017 marks the 30th anniversary of the birth of modern deep brain stimulation (DBS), which was introduced by Benabid, Pollak et al. in 1987, initially targeting the motor thalamus to treat tremor, and subsequently targeting the subthalamic nucleus (STN) for treatment of symptoms of advanced Parkinson's disease (PD). STN DBS is undoubtedly "the most important discovery since levodopa", as stated by David Marsden in 1994. In 2014, The Lasker- DeBakey Clinical Medical Research Award to "honor two scientists who developed deep brain stimulation of the subthalamic nucleus", was bestowed upon Benabid and DeLong...
2017: Journal of Parkinson's Disease
https://www.readbyqxmd.com/read/28280646/meta-analysis-of-the-relationship-between-deep-brain-stimulation-in-patients-with-parkinson-s-disease-and-performance-in-evaluation-tests-for-executive-brain-functions
#14
REVIEW
A M Martínez-Martínez, O M Aguilar, C A Acevedo-Triana
Parkinson's disease (PD) is a neurodegenerative condition, which compromises the motor functions and causes the alteration of some executive brain functions. The presence of changes in cognitive symptoms in PD could be due to the procedure of deep brain stimulation (DBS). We searched in several databases for studies that compared performance in executive function tests before and after the DBS procedure in PE and then performed a meta-analysis. After the initial search, there were 15 articles that specifically evaluated the functions of verbal fluency, working memory, cognitive flexibility, abstract thinking, and inhibition...
2017: Parkinson's Disease
https://www.readbyqxmd.com/read/28279773/deep-brain-stimulation-of-pedunculopontine-nucleus-for-postural-instability-and-gait-disorder-after-parkinson-s-disease-a-meta-analysis-of-individual-patient-data
#15
Jia-Wei Wang, Yu-Qing Zhang, Xiao-Hua Zhang, Yun-Peng Wang, Ji-Ping Li, Yong-Jie Li
BACKGROUND: Postural instability and gait disorder(PIGD) in Parkinson's disease (PD) have been a great challenge in the clinical practice since PIGD is closely linked to major morbidity and mortality in PD. Pedunculopontine nucleus (PPN) has been considered as a potential promising target for deep brain stimulation (DBS) in the treatment of PIGD. Thus, this meta-analysis of individual patient data (IPD) was performed to assess the effects of PPN DBS on PIGD in PD patients and explore the factors predicting good outcome...
March 6, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28279509/-medical-and-surgical-treatment-of-parkinson-s-disease
#16
Luc Defebvre, Caroline Moreau
The treatment of Parkinson's disease is symptomatic with the use of dopaminergic medications: levodopa, dopaminergic agonists and enzymatic inhibitors. At the initial stage, the main goals are to improve the quality of life of patients and delay the onset of motor complications, using a combination of these therapies taking into account both clinical disability and tolerance of different treatments. At the stage of motor and non-motor fluctuations inhibitors of MAO-B and COMT are proposed; amantadine may limit moderate dyskinesias...
March 6, 2017: La Presse Médicale
https://www.readbyqxmd.com/read/28273176/pulsatile-desynchronizing-delayed-feedback-for-closed-loop-deep-brain-stimulation
#17
Oleksandr V Popovych, Borys Lysyansky, Michael Rosenblum, Arkady Pikovsky, Peter A Tass
High-frequency (HF) deep brain stimulation (DBS) is the gold standard for the treatment of medically refractory movement disorders like Parkinson's disease, essential tremor, and dystonia, with a significant potential for application to other neurological diseases. The standard setup of HF DBS utilizes an open-loop stimulation protocol, where a permanent HF electrical pulse train is administered to the brain target areas irrespectively of the ongoing neuronal dynamics. Recent experimental and clinical studies demonstrate that a closed-loop, adaptive DBS might be superior to the open-loop setup...
2017: PloS One
https://www.readbyqxmd.com/read/28269578/a-comparative-study-of-approaches-to-compute-the-field-distribution-of-deep-brain-stimulation-in-the-hemiparkinson-rat-model
#18
Andrea Bohme, Ursula van Rienen
Computational modeling of the stimulating field distribution during Deep Brain Stimulation provides an opportunity to advance our knowledge of this neurosurgical therapy for Parkinson's disease. There exist several approaches to model the target region for Deep Brain Stimulation in Hemi-parkinson Rats with volume conductor models. We have described and compared the normalized mapping approach as well as the modeling with three-dimensional structures, which include curvilinear coordinates to assure an anatomically realistic conductivity tensor orientation...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28269576/detection-of-single-unit-spikes-during-orthodromic-high-frequency-stimulation-in-rat-hippocampus
#19
Zhaoxiang Wang, Zhouyan Feng, Ying Yu, Yufang Zhu, Zheshan Guo
Deep brain stimulation (DBS) has been used as a treatment of brain diseases such as Parkinson's disease and is a promising therapy for epilepsy. But the mechanisms of high frequency stimulation (HFS) used by DBS are still uncertain. In order to investigate the changes of action penitential firings of individual neurons (single unit activity, SUA) during the period of HFS, a new algorithm based on window detection was designed to detect spikes in broadband-frequency recording signals. The results show that orthodromic-HFS (O-HFS) could excite the neurons in CA1 regions, and the firing rate of interneurons and pyramidal neurons increased significantly...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28269510/network-effects-and-pathways-in-deep-brain-stimulation-in-parkinson-s-disease
#20
N Koirala, V Fleischer, O Granert, G Deuschl, M Muthuraman, S Groppa
Deep brain stimulation of subthalamic nucleus (STN-DBS) became a standard therapeutic option in Parkinson's disease (PD), even though the underlying modulated network of STN-DBS is still poorly described. Probabilistic tractography and connectivity analysis as derived from diffusion tensor imaging (DTI) were performed together with modelling of implanted electrode positions and linked postoperative clinical outcome. Fifteen patients with idiopathic PD without dementia were selected for DBS treatment. After pre-processing, probabilistic tractography was run from cortical and subcortical seeds of the hypothesized network to targets represented by the positions of the active DBS contacts...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
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