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Parkinson's Disease, Deep brain stimulation

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https://www.readbyqxmd.com/read/28643808/parkinson-disease-deep-brain-stimulation-making-the-right-connections
#1
Charlotte Ridler
No abstract text is available yet for this article.
June 23, 2017: Nature Reviews. Neurology
https://www.readbyqxmd.com/read/28642341/use-of-intraoperative-local-field-potential-spectral-analysis-to-differentiate-basal-ganglia-structures-in-parkinson-s-disease-patients
#2
Rachel Kolb, Aviva Abosch, Gidon Felsen, John A Thompson
Identification of brain structures traversed during implantation of deep brain-stimulating (DBS) electrodes into the subthalamic nucleus (STN-DBS) for the treatment of Parkinson's disease (PD) frequently relies on subjective correspondence between kinesthetic response and multiunit activity. However, recent work suggests that local field potentials (LFP) could be used as a more robust signal to objectively differentiate subcortical structures. The goal of this study was to analyze the spectral properties of LFP collected during STN-DBS in order to objectively identify commonly traversed brain regions and improve our understanding of aberrant oscillations in the PD-related pathophysiological cortico-basal ganglia network...
June 2017: Physiological Reports
https://www.readbyqxmd.com/read/28641127/deep-brain-stimulation-of-subthalamic-nucleus-helps-in-improving-late-phase-motor-planning-in-parkinson-s-disease
#3
Patil Ashlesh, Sood Sanjay Kumar, Kochhar Kanwal Preet, Goyal Vinay
OBJECTIVE: Deep brain stimulation of subthalamic nucleus (DBS-STN) is a well-accepted treatment for Parkinson's disease (PD) but its effect on motor planning in the disease is yet unclear. This study examines the effect of switching the stimulation ON and OFF on components of bereitschaftspotentials in PD. PATIENTS AND METHODS: Scalp bereitschaftspotentials were recorded during self-paced right wrist extensions at Fz, Cz, Pz, C3 and C4 sites in patients on DBS-STN plus medications (DBS-STN group) as treatment modality or on medications only (Med group) and compared with age matched healthy controls...
June 15, 2017: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/28639263/subthalamic-beta-dynamics-mirror-parkinsonian-bradykinesia-months-after-neurostimulator-implantation
#4
Leon Amadeus Steiner, Wolf-Julian Neumann, Franziska Staub-Bartelt, Damian M Herz, Huiling Tan, Alek Pogosyan, Andrea A Kuhn, Peter Brown
BACKGROUND: Exaggerated oscillatory activity in the beta frequency band in the subthalamic nucleus has been suggested to be related to bradykinesia in Parkinson's disease (PD). However, studies seeking correlations between such activity in the local field potential and motor performance have been limited to the immediate postoperative period, which may be confounded by a stun effect that leads to the temporary alleviation of PD deficits. METHODS: Local field potentials were recorded simultaneously with motor performance in PD patients several months after neurostimulator implantation...
June 22, 2017: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/28638714/swallowing-safety-in-parkinson-s-disease-after-zona-incerta-deep-brain-stimulation
#5
Stina Sundstedt, Lina Holmén, Elin Rova, Jan Linder, Erik Nordh, Katarina Olofsson
OBJECTIVES: The objective of this study was to examine swallowing function in patients with Parkinson's disease before and after caudal zona incerta deep brain (cZI DBS) surgery. The aims were to examine the effect of cZI DBS on swallowing safety regarding liquid and solid food, as well as to identify the effect of cZI DBS on body mass index (BMI) and specific items from part II of the Unified Parkinson's Disease Rating Scale (UPDRS). MATERIALS AND METHODS: The median age of the 14 patients was 57 years (range 46-71), with a median disease duration of 6 years (range 2-13)...
June 2017: Brain and Behavior
https://www.readbyqxmd.com/read/28631129/optimizing-the-deep-brain-stimulation-care-pathway-in-patients-with-parkinson-s-disease
#6
N J Thomas, P Mertens, T Danaila, G Polo, H Klinger, E Broussolle, S Thobois
Management of Parkinson's disease (PD) using deep brain stimulation (DBS) requires complex care in specialized, multidisciplinary centers. A well-organized, efficient patient flow is crucial to ensure that eligible patients can quickly access DBS. Delays or inefficiencies in patient care may impact a center's ability to meet demand, creating a capacity bottleneck. Analysis of the current practices within a center may help identify areas for improvement. After external audit of the DBS workflow of the Lyon Neurological Hospital and comparison with other European centers, manageable steps were suggested to restructure the care pathway...
June 19, 2017: Journal of Neurology
https://www.readbyqxmd.com/read/28620349/localization-of-deep-brain-stimulation-contacts-using-corticospinal-corticobulbar-tracts-stimulation
#7
Julien F Bally, Maria-Isabel Vargas, Judit Horvath, Vanessa Fleury, Pierre Burkhard, Shahan Momjian, Pierre Pollak, Colette Boex
BACKGROUND: Successful deep brain stimulation (DBS) in Parkinson's disease (PD) requires optimal electrode placement. One technique of intraoperative electrode testing is determination of stimulation thresholds inducing corticospinal/corticobulbar tracts (CSBT) motor contractions. OBJECTIVE: This study aims to analyze correlations between DBS electrode distance to CSBT and contraction thresholds, with either visual or electromyography (EMG) detection, to establish an intraoperative tool devoted to ensure safe distance of the electrode to the CSBT...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/28616028/need-for-multiple-biomarkers-to-adjust-parameters-of-closed-loop-deep-brain-stimulation-for-parkinson-s-disease
#8
Takashi Morishita, Tooru Inoue
No abstract text is available yet for this article.
May 2017: Neural Regeneration Research
https://www.readbyqxmd.com/read/28615985/treatment-of-movement-disorders-with-focused-ultrasound
#9
REVIEW
Paul S Fishman, Victor Frenkel
Although the use of ultrasound as a potential therapeutic modality in the brain has been under study for several decades, relatively few neuroscientists or neurologists are familiar with this technology. Stereotactic brain lesioning had been widely used as a treatment for medically refractory patients with essential tremor (ET), Parkinson disease (PD), and dystonia but has been largely replaced by deep brain stimulation (DBS) surgery, with advantages both in safety and efficacy. However, DBS is associated with complications including intracerebral hemorrhage, infection, and hardware malfunction...
2017: Journal of Central Nervous System Disease
https://www.readbyqxmd.com/read/28615151/parkinson-s-disease-patient-preference-and-experience-with-various-methods-of-dbs-lead-placement
#10
Sara C LaHue, Jill L Ostrem, Nicholas B Galifianakis, Marta San Luciano, Nathan Ziman, Sarah Wang, Caroline A Racine, Philip A Starr, Paul S Larson, Maya Katz
INTRODUCTION: Physiology-guided deep brain stimulation (DBS) surgery requires patients to be awake during a portion of the procedure, which may be poorly tolerated. Interventional MRI-guided (iMRI) DBS surgery was developed to use real-time image guidance, obviating the need for patients to be awake during lead placement. METHODS: All English-speaking adults with PD who underwent iMRI DBS between 2010 and 2014 at our Center were invited to participate. Subjects completed a structured interview that explored perioperative preferences and experiences...
April 17, 2017: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/28607168/subthalamic-nucleus-deep-brain-stimulation-employs-trkb-signaling-for-neuroprotection-and-functional-restoration
#11
D Luke Fischer, Christopher J Kemp, Allyson Cole-Strauss, Nicole K Polinski, Katrina L Paumier, Jack W Lipton, Kathy Steece-Collier, Timothy J Collier, Daniel J Buhlinger, Caryl E Sortwell
Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is the most common neurosurgical treatment for Parkinson's disease motor symptoms. In preclinical models, STN DBS provides neuroprotection for substantia nigra (SN) dopamine neurons and increases brain-derived neurotrophic factor (BDNF) in the nigrostriatal system and primary motor cortex. However, whether BDNF signaling in the SN participates in the neuroprotective effects of DBS remains unknown. We demonstrate that STN DBS in male rats activates signaling downstream of tropomyosin receptor kinase type B (trkB), namely phosphorylation of Akt and ribosomal protein S6, in SN neurons...
June 12, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28606582/patients-perioperative-experience-of-awake-deep-brain-stimulation-for-parkinson-s-disease
#12
Eoin Mulroy, Nigel Robertson, Lorraine Macdonald, Arnold Bok, Mark Simpson
BACKGROUND: Awake craniotomy for tumor resection and epilepsy surgery is a well-tolerated procedure. Qualitative data on patients' experience of awake deep brain stimulation (DBS) is however, lacking. We collected qualitative data on patients' experience of awake DBS with a view to identifying areas for improvement. METHODS: Forty-one patients undergoing DBS for Parkinson's disease (PD) between 2009 and 2015 were surveyed using a structured questionnaire designed to receive patient feedback regarding perioperative management of the awake stage of the procedure CONCLUSIONS: Though awake DBS is well-tolerated, pain and off-period symptoms are an issue for a significant number of patients...
June 9, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28605052/effects-of-pedunculopontine-nucleus-stimulation-on-human-bladder-function
#13
Holly A Roy, Debbie Pond, Christopher Roy, Beth Forrow, Thomas Foltynie, Ludvic Zrinzo, Harith Akram, Tipu Z Aziz, James J FitzGerald, Alexander L Green
AIMS: The pedunculopontine nucleus (PPN) is a deep brain stimulation target for Parkinson's disease (PD). Unilateral PPN stimulation has been described in a previous case report to provoke urinary frequency, urgency and detrusor overactivity, due to probable activation of the pontine micturition center. Our aim was to evaluate the effect of bilateral PPN DBS on urodynamic parameters and to investigate the likely mechanisms using probabilistic tractography. METHODS: Six male PD subjects with bilateral PPN deep brain stimulators were recruited...
June 12, 2017: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/28601961/basal-ganglia-movement-disorders-and-deep-brain-stimulation-advances-made-through-non-human-primate-research
#14
REVIEW
Thomas Wichmann, Hagai Bergman, Mahlon R DeLong
Studies in non-human primates (NHPs) have led to major advances in our understanding of the function of the basal ganglia and of the pathophysiologic mechanisms of hypokinetic movement disorders such as Parkinson's disease and hyperkinetic disorders such as chorea and dystonia. Since the brains of NHPs are anatomically very close to those of humans, disease states and the effects of medical and surgical approaches, such as deep brain stimulation (DBS), can be more faithfully modeled in NHPs than in other species...
June 10, 2017: Journal of Neural Transmission
https://www.readbyqxmd.com/read/28598194/the-use-of-neurocomputational-models-as-alternatives-to-animal-models-in-the-development-of-electrical-brain-stimulation-treatments
#15
Anne Beuter
Recent publications call for more animal models to be used and more experiments to be performed, in order to better understand the mechanisms of neurodegenerative disorders, to improve human health, and to develop new brain stimulation treatments. In response to these calls, some limitations of the current animal models are examined by using Deep Brain Stimulation (DBS) in Parkinson's disease as an illustrative example. Without focusing on the arguments for or against animal experimentation, or on the history of DBS, the present paper argues that given recent technological and theoretical advances, the time has come to consider bioinspired computational modelling as a valid alternative to animal models, in order to design the next generation of human brain stimulation treatments...
May 2017: Alternatives to Laboratory Animals: ATLA
https://www.readbyqxmd.com/read/28597557/adaptive-deep-brain-stimulation-for-movement-disorders-the-long-road-to-clinical-therapy
#16
REVIEW
Anders Christian Meidahl, Gerd Tinkhauser, Damian Marc Herz, Hayriye Cagnan, Jean Debarros, Peter Brown
Continuous high-frequency DBS is an established treatment for essential tremor and Parkinson's disease. Current developments focus on trying to widen the therapeutic window of DBS. Adaptive DBS (aDBS), where stimulation is dynamically controlled by feedback from biomarkers of pathological brain circuit activity, is one such development. Relevant biomarkers may be central, such as local field potential activity, or peripheral, such as inertial tremor data. Moreover, stimulation may be directed by the amplitude or the phase (timing) of the biomarker signal...
June 2017: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/28594735/pro-general-anesthesia-for-deep-brain-stimulator-insertion-in-patients-with-parkinson-disease
#17
Lashmi Venkatraghavan, Veena Sheshadri
No abstract text is available yet for this article.
July 2017: Journal of Neurosurgical Anesthesiology
https://www.readbyqxmd.com/read/28592690/dynamics-of-human-subthalamic-neuron-phase-locking-to-motor-and-sensory-cortical-oscillations-during-movement
#18
Witold J Lipski, Thomas A Wozny, Ahmad Alhourani, Efstathios Kondylis, Robert S Turner, Donald J Crammond, Robert Mark Richardson
Coupled oscillatory activity recorded between sensorimotor regions of the basal ganglia-thalamocortical loop is thought to reflect information transfer relevant to movement. A neuronal firing-rate model of basal ganglia-thalamocortical circuitry, however, has dominated thinking about basal ganglia function for the past three decades, without knowledge of the relationship between basal ganglia single neuron firing and cortical population activity during movement itself. We recorded activity from 34 subthalamic nucleus (STN) neurons, simultaneously with cortical local field potentials and motor output, in eleven subjects with Parkinson's disease (PD) undergoing awake deep brain stimulator lead placement...
June 7, 2017: Journal of Neurophysiology
https://www.readbyqxmd.com/read/28590521/seventy-years-with-the-globus-pallidus-pallidal-surgery-for-movement-disorders-between-1947-and-2017
#19
REVIEW
Laura Cif, Marwan Hariz
The year 2017 marks the 70th anniversary of the birth of human stereotactic neurosurgery. The first procedure was a pallidotomy for Huntington's disease. However, it was for Parkinson's disease that pallidotomy was soon adopted worldwide. Pallidotomy was abandoned in the late 1950s in favor of thalamotomy because of the latter's more striking effect on tremor. The advent of levodopa put a halt to all surgery for PD. In the mid-1980s, Laitinen reintroduced the posteroventral pallidotomy of Leksell, and this procedure spread worldwide thanks to its efficacy on most parkinsonian symptoms including levodopa-induced dyskinesias and thanks to basic scientific work confirming the role of the globus pallidus internus in the pathophysiology of PD...
June 7, 2017: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/28590508/pyramidal-tract-activation-due-to-subthalamic-deep-brain-stimulation-in-parkinson-s-disease
#20
Philipp Mahlknecht, Harith Akram, Dejan Georgiev, Elina Tripoliti, Joseph Candelario, Andre Zacharia, Ludvic Zrinzo, Jonathan Hyam, Marwan Hariz, Thomas Foltynie, John C Rothwell, Patricia Limousin
BACKGROUND: Subthalamic deep brain stimulation (STN-DBS) is an effective treatment for Parkinson's disease (PD), but can have side effects caused by stimulus spread to structures outside the target volume such as the pyramidal tract. OBJECTIVES: To assess the relevance of pyramidal tract activation with STN-DBS in PD. METHODS: In a multimodal, blinded study in 20 STN-DBS patients, we measured stimulation thresholds for evoking electromyographic activity in orbicularis oris and first dorsal interosseous muscles at each of 150 electrode sites...
June 7, 2017: Movement Disorders: Official Journal of the Movement Disorder Society
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