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Parkinson's Disease, Deep brain stimulation

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https://www.readbyqxmd.com/read/29775152/semi-automated-application-for-estimating-subthalamic-nucleus-boundaries-and-optimal-target-selection-for-deep-brain-stimulation-implantation-surgery
#1
John A Thompson, Salam Oukal, Hagai Bergman, Steven Ojemann, Adam O Hebb, Sara Hanrahan, Zvi Israel, Aviva Abosch
OBJECTIVE Deep brain stimulation (DBS) of the subthalamic nucleus (STN) has become standard care for the surgical treatment of Parkinson's disease (PD). Reliable interpretation of microelectrode recording (MER) data, used to guide DBS implantation surgery, requires expert electrophysiological evaluation. Recent efforts have endeavored to use electrophysiological signals for automatic detection of relevant brain structures and optimal implant target location. The authors conducted an observational case-control study to evaluate a software package implemented on an electrophysiological recording system to provide online objective estimates for entry into and exit from the STN...
May 18, 2018: Journal of Neurosurgery
https://www.readbyqxmd.com/read/29767379/individual-cognitive-change-after-dbs-surgery-in-parkinson-s-disease-patients-using-reliable-change-index-methodology
#2
Thomas Foki, Daniela Hitzl, Walter Pirker, Klaus Novak, Gisela Pusswald, Johann Lehrner
Long-term therapy of Parkinson's disease (PD) with levodopa (L-DOPA) is associated with a high risk of developing motor fluctuations and dyskinesia. Deep brain stimulation (DBS) in PD patients of the subthalamic nucleus can improve these motor complications. Although the positive effect on motor symptoms has been proven, postoperative cognitive decline has been documented. To tackle the impact of PD-DBS on cognition, 18 DBS patients were compared to 25 best medically treated Parkinson's patients, 24 Mild Cognitive Impairment (MCI) patients and 12 healthy controls using the Neuropsychological Test Battery Vienna-long (NTBV-long) for cognitive outcome 12 months after first examination...
May 16, 2018: Neuropsychiatrie: Klinik, Diagnostik, Therapie und Rehabilitation
https://www.readbyqxmd.com/read/29762549/frameless-stereotaxis-for-subthalamic-nucleus-deep-brain-stimulation-an-innovative-method-for-the-direct-visualization-of-electrode-implantation-by-intraoperative-x-ray-control
#3
Paolo Mazzone, Alessandro Stefani, Fabio Viselli, Eugenio Scarnati
The recent introduction of frameless devices has enabled stereotactic neurosurgery to reach a level of accuracy that is comparable to traditional frame-based methodologies. Among frameless devices, the Nexframe appears to be very useful in implanting electrodes into the subthalamic nucleus or other structures for deep brain stimulation in Parkinson's disease. However, frameless devices, including the Nexframe, limit the possibility of intraoperative visual control of the placement of electrodes in the brain...
May 15, 2018: Brain Sciences
https://www.readbyqxmd.com/read/29760182/alternating-modulation-of-subthalamic-nucleus-beta-oscillations-during-stepping
#4
Petra Fischer, Chiung Chu Chen, Ya Ju Chang, Chien-Hung Yeh, Alek Pogosyan, Damian M Herz, Binith Cheeran, Alexander L Green, Tipu Z Aziz, Jonathan Hyam, Simon Little, Thomas Foltynie, Patricia Limousin, Ludvic Zrinzo, Harutomo Hasegawa, Michael Samuel, Keyoumars Ashkan, Peter Brown, Huiling Tan
Gait disturbances in Parkinson's disease are commonly refractory to current treatment options and majorly impair patient's quality of life. Auditory cues facilitate gait and prevent motor blocks. We investigated how neural dynamics in the human subthalamic nucleus of Parkinsons's disease patients (14 male, 2 female) vary during stepping and whether rhythmic auditory cues enhance the observed modulation. Oscillations in the beta band were suppressed after ipsilateral heel strikes, when the contralateral foot had to be raised, and re-appeared after contralateral heel strikes, when the contralateral foot rested on the floor...
May 14, 2018: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/29757774/can-telerehabilitation-games-lead-to-functional-improvement-of-upper-extremities-in-individuals-with-parkinson-s-disease
#5
Imre Cikajlo, Alma Hukić, Irena Dolinšek, Dejana Zajc, Mateja Vesel, Tatjana Krizmanič, Bojan Blažica, Anton Biasizzo, Franc Novak, Karmen Peterlin Potisk
Parkinson's disease (PD) is treated by medication, less with deep brain stimulation and physiotherapy. Different opinions on the clinical meaningfulness of the physiotherapy or recommended intensive physiotherapy were found. Our objectives were to design intensive target-based physiotherapy for upper extremities suitable for telerehabilitation services and examine the clinical meaningfulness of the exergaming at an unchanged medication plan. A telerehabilitation exergaming system using the Kinect sensor was developed; 28 patients with PD participated in the study...
May 4, 2018: International Journal of Rehabilitation Research. Revue Internationale de Recherches de Réadaptation
https://www.readbyqxmd.com/read/29755729/deep-brain-stimulation-in-parkinson-s-disease
#6
EDITORIAL
Raja Mehanna, Hubert H Fernandez, Aparna Wagle Shukla, Jawad A Bajwa
No abstract text is available yet for this article.
2018: Parkinson's Disease
https://www.readbyqxmd.com/read/29755338/a-review-of-the-pedunculopontine-nucleus-in-parkinson-s-disease
#7
REVIEW
Isobel T French, Kalai A Muthusamy
The pedunculopontine nucleus (PPN) is situated in the upper pons in the dorsolateral portion of the ponto-mesencephalic tegmentum. Its main mass is positioned at the trochlear nucleus level, and is part of the mesenphalic locomotor region (MLR) in the upper brainstem. The human PPN is divided into two subnuclei, the pars compacta (PPNc) and pars dissipatus (PPNd), and constitutes both cholinergic and non-cholinergic neurons with afferent and efferent projections to the cerebral cortex, thalamus, basal ganglia (BG), cerebellum, and spinal cord...
2018: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/29751598/informed-consent-decision-making-in-deep-brain-stimulation
#8
REVIEW
Gabriele Mandarelli, Germana Moretti, Massimo Pasquini, Giuseppe Nicolò, Stefano Ferracuti
Deep brain stimulation (DBS) has proved useful for several movement disorders (Parkinson’s disease, essential tremor, dystonia), in which first and/or second line pharmacological treatments were inefficacious. Initial evidence of DBS efficacy exists for refractory obsessive-compulsive disorder, treatment-resistant major depressive disorder, and impulse control disorders. Ethical concerns have been raised about the use of an invasive surgical approach involving the central nervous system in patients with possible impairment in cognitive functioning and decision-making capacity...
May 11, 2018: Brain Sciences
https://www.readbyqxmd.com/read/29751070/deep-brain-stimulation-enhances-movement-complexity-during-gait-in-individuals-with-parkinson-s-disease
#9
Douglas W Powell, Sarah E Blackmore, Melissa Puppa, Deranda Lester, Nicholas G Murray, Rebecca J Reed-Jones, Rui-Ping Xia
Deep brain stimulation (DBS) is associated with substantial improvements in motor symptoms of PD. Emerging evidence has suggested that nonlinear measures of complexity may provide greater insight into the efficacy of anti-PD treatments. This study investigated sample entropy and complexity index values in individuals with PD when DBS was OFF compared to ON. Five individuals with PD using DBS performed a four-minute treadmill walking task while 3D kinematics were collected over two periods of 30 seconds. Participants were tested in the DBS-ON and DBS-OFF conditions...
May 8, 2018: Neuroscience Letters
https://www.readbyqxmd.com/read/29746889/modular-auditory-decision-making-behavioral-task-designed-for-intraoperative-use-in-humans
#10
Anand Tekriwal, Gidon Felsen, John A Thompson
BACKGROUND: Neurosurgical interventions that require active patient feedback, such as deep brain stimulation surgery, create an opportunity to conduct cognitive or behavioral experiments during the acquisition of invasive neurophysiology. Optimal design and implementation of intraoperative behavioral experiments require consideration of stimulus presentation, time and surgical constraints. We describe the use of a modular, inexpensive system that implements a decision-making paradigm, designed to overcome challenges associated with the operative environment...
May 7, 2018: Journal of Neuroscience Methods
https://www.readbyqxmd.com/read/29741160/adaptive-deep-brain-stimulation-for-parkinson-s-disease-using-motor-cortex-sensing
#11
Nicole C Swann, Coralie de Hemptinne, Margaret C Thompson, Svjetlana Miocinovic, Andrew M Miller, Ro'ee Gilron, Jill L Ostrem, Howard J Chizeck, Philip A Starr
OBJECTIVE: Contemporary deep brain stimulation (DBS) for Parkinson's disease is delivered continuously, and adjustments based on patient's changing symptoms must be made manually by a trained clinician. Patients may be subjected to energy intensive settings at times when they are not needed, possibly resulting in stimulation-induced adverse effects, such as dyskinesia. One solution is 'adaptive' DBS, in which stimulation is modified in real time based on neural signals that co-vary with the severity of motor signs or of stimulation-induced adverse effects...
May 9, 2018: Journal of Neural Engineering
https://www.readbyqxmd.com/read/29736590/anatomical-predictors-of-cognitive-decline-after-subthalamic-stimulation-in-parkinson-s-disease
#12
Vincent Planche, Fanny Munsch, Bruno Pereira, Emmanuel de Schlichting, Tiphaine Vidal, Jerome Coste, Dominique Morand, Ingrid de Chazeron, Philippe Derost, Bérangère Debilly, Pierre-Michel Llorca, Jean-Jacques Lemaire, Ana Marques, Franck Durif
We investigated whether pre-operative MRI measures of focal brain atrophy could predict cognitive decline occurring after deep brain stimulation (DBS) of the subthalamic nucleus (STN) in patients with Parkinson's disease (PD). For that purpose, we prospectively collected data of 42 consecutive patients with PD who underwent bilateral STN-DBS. Normalized brain structure volumes and cortical thicknesses were measured on pre-operative T1-weighted MRI. Patients were tested for their cognitive performances before surgery and 1 year after...
May 7, 2018: Brain Structure & Function
https://www.readbyqxmd.com/read/29731935/technical-case-report-of-deep-brain-stimulation-is-it-possible-single-electrode-reach-to-both-of-subthalamic-nucleus-and-ventral-intermediate-nucleus-in-one-stage
#13
Hülagu Kaptan, Raif Çakmur
BACKGROUND: The primary target of this operation is Ventral Intermediate Nucleus (VIM); however VIM - Subthalamic Nucleus (STN) were tried to be reached with one electrode, adjusting the angle well, the coronal section; medial of VIM can partially reach the STN. Using the properties of the electrode; we believe we could act on a wide area. METHODS: An analysis was performed on one patient who underwent VIM Deep Brain Stimulation (DBS) in 3 periods (pre - peri - post-operation)...
April 15, 2018: Open Access Macedonian Journal of Medical Sciences
https://www.readbyqxmd.com/read/29729543/craniotomy-for-subdural-hematoma-after-deep-brain-stimulation-surgery-outcomes-and-satisfaction-in-a-case-series-of-two-patients
#14
Gordon Mao, Michael J Gigliotti, Cindy Angle, Donald Whiting, Nestor Tomycz
OBJECTIVE: To determine whether salvage of DBS hardware is beneficial for Parkinson's Disease (PD) patients by looking at follow-up patient's outcomes and satisfaction after their craniotomy operation. PATIENTS AND METHODS: This was a retrospective review of a prospective, single-center deep brain stimulation (DBS) database between 2002-2016 identifying patients with PD who developed subdural hematomas (SDH) due to trauma after their DBS surgery. Of the 636 DBS cases that were performed, 3 PD-DBS patients with significant traumatic SDH managed via craniotomy were identified...
April 27, 2018: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/29727475/subthalamic-nucleus-deep-brain-stimulation-evokes-resonant-neural-activity
#15
Nicholas C Sinclair, Hugh J McDermott, Kristian J Bulluss, James B Fallon, Thushara Perera, San San Xu, Peter Brown, Wesley Thevathasan
Deep brain stimulation (DBS) is a rapidly expanding treatment for neurological and psychiatric conditions; however, a target-specific biomarker is required to optimize therapy. Here, we show that DBS evokes a large-amplitude resonant neural response focally in the subthalamic nucleus. This response is greatest in the dorsal region (the clinically optimal stimulation target for Parkinson disease), coincides with improved clinical performance, is chronically recordable, and is present under general anesthesia...
May 4, 2018: Annals of Neurology
https://www.readbyqxmd.com/read/29727341/-it-is-hard-work-but-it-is-worth-it-patients-and-spouses-experiences-of-a-nursing-intervention-to-promote-adjustment-to-deep-brain-stimulation-for-parkinson-s-disease-a-feasibility-study
#16
Anita Haahr, Karen Østergaard, Marit Kirkevold
This article evaluates the feasibility of a nursing intervention when adjusting to deep brain stimulation for Parkinson disease. Eight couples were included in the study. Main activities of the intervention were a diary and individualized meetings between nurses, patients, and spouses with a focus on everyday life and expectations to deep brain stimulation. All meetings were audio recorded and analyzed together with the content of the diary. The intervention was evaluated as feasible and experienced as meaningful...
April 2018: ANS. Advances in Nursing Science
https://www.readbyqxmd.com/read/29719720/chinese-expert-consensus-on-programming-deep-brain-stimulation-for-patients-with-parkinson-s-disease
#17
REVIEW
Shengdi Chen, Guodong Gao, Tao Feng, Jianguo Zhang
Background: Deep Brain Stimulation (DBS) therapy for the treatment of Parkinson's Disease (PD) is now a well-established option for some patients. Postoperative standardized programming processes can improve the level of postoperative management and programming, relieve symptoms and improve quality of life. Main body: In order to improve the quality of the programming, the experts on DBS and PD in neurology and neurosurgery in China reviewed the relevant literatures and combined their own experiences and developed this expert consensus on the programming of deep brain stimulation in patients with PD in China...
2018: Translational Neurodegeneration
https://www.readbyqxmd.com/read/29713577/subthalamic-and-pallidal-deep-brain-stimulation-for-parkinson-s-disease
#18
REVIEW
Ahmed Negida, Mohamed Elminawy, Gehad El Ashal, Ahmed Essam, Athar Eysa, Mohamed Abd Elalem Aziz
Deep brain stimulation (DBS) is a surgical treatment in which stimulation electrodes are permanently implanted in basal ganglia to treat motor fluctuations and symptoms of Parkinson's disease (PD). Subthalamic nucleus (STN) and globus pallidus internus (GPi) are the commonly used targets for DBS in PD. Many studies have compared motor and non-motor outcomes of DBS in both targets. However, the selection of PD patients for DBS targets is still poorly studied. Therefore, we performed this narrative review to summarize published studies comparing STN DBS and GPi DBS...
February 26, 2018: Curēus
https://www.readbyqxmd.com/read/29712499/lightning-may-pose-a-danger-to-patients-receiving-deep-brain-stimulation-case-report
#19
Neža Prezelj, Maja Trošt, Dejan Georgiev, Dušan Flisar
Deep brain stimulation (DBS) is an established treatment option for advanced stages of Parkinson's disease and other movement disorders. It is known that DBS is susceptible to strong electromagnetic fields (EMFs) that can be generated by various electrical devices at work, home, and in medical environments. EMFs can interfere with the proper functioning of implantable pulse generators (IPGs). Very strong EMFs can generate induction currents in implanted electrodes and even damage the brain. Manufacturers of DBS devices have issued a list of warnings on how to avoid this danger...
May 1, 2018: Journal of Neurosurgery
https://www.readbyqxmd.com/read/29709756/deep-brain-stimulation-for-parkinson-s-disease-in-the-philippines-outcomes-of-the-philippine-movement-disorder-surgery-center
#20
Jose Danilo B Diestro, Theodor S Vesagas, Rosalia A Teleg, Jose A Aguilar, Joseph P Anlacan, Roland Dominic G Jamora
OBJECTIVE: Deep brain stimulation (DBS) is an established treatment modality for Parkinson's Disease (PD). The first DBS for PD in the Philippines was done at the Philippine Movement Disorder Surgery Center (PhilMove) in 2006. There is no Philippine data on DBS for PD. We aim to determine the motor improvement and reduction in medication dosage of all PD patients who underwent DBS at PhilMove. METHODS: This is a retrospective study of all PD patients (n=17) who underwent DBS from 2006-2016...
April 27, 2018: World Neurosurgery
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