Katsuya Yamamoto, Shinichiro Kawamoto, Ruri Chijiki, Marika Watanabe, Sakuya Matsumoto, Akihito Kitao, Yu Mizutani, Kazuyoshi Kajimoto, Yoshitake Hayashi, Kimikazu Yakushijin, Hironobu Minami
A 68-year-old man was admitted because of a left shoulder mass and swollen right testis. Pathological examinations indicated a diagnosis of diffuse large B-cell lymphoma (DLBCL) with the CD20+BCL6+MUM1+BCL2+CD10-MYC- phenotype in both lesions. G-banding of soft tissue showed 47,XY,+18, whereas testicular cells showed 47,X,+X,-Y,der (4) t (4;18) (p15;?),del (5) (q?),+13. Fluorescence in situ hybridization detected additional MALT1 and BCL2 signals in both lesions. Southern blot demonstrated different IGH rearrangements between the soft tissue and testis...
June 14, 2022: Internal Medicine