keyword
https://read.qxmd.com/read/37900803/generalized-lymphatic-anomaly-as-a-differential-diagnosis-of-lytic-lesions
#21
Greta Catani, Federico Waisberg, Diego Enrico, Andrés Rodriguez, Yanina Pflüger, María Laura Galluzzo, María Del Valle Centeno, Isabel Colmenero, Mora Amat, Lisandro Paganini, Anna Frida García Herrmann, Matías Chacón
Generalized lymphatic anomaly (GLA) is an infrequent multiorgan disease characterized by the presence of abnormal proliferation of lymphatic vessels. The diagnosis requires histological confirmation, and the treatment is controversial. We are presenting a case of a 28-year-old male patient who was diagnosed with an extragonadal mediastinal nonseminomatous germ cell tumor. He underwent chemotherapy, and during this treatment, radiologic findings evidenced lytic lesions. Multiple biopsies were performed, which revealed the presence of abnormal lymphatic vessels, characteristic of GLA...
2023: Case Reports in Oncology
https://read.qxmd.com/read/37853566/second-hematologic-malignancies-associated-with-primary-mediastinal-germ-cell-tumors-a-population-based-study
#22
JOURNAL ARTICLE
David Aguiar-Bujanda, Laura Croissier-Sánchez, Daniel Pérez-Cabrera, Saray Galván-Ruiz
BACKGROUND: Studies addressing second hematologic malignancies (SHMs) in patients with primary mediastinal germ cell tumors (PMGCTs) are scarce. To better describe this phenomenon, we analyzed a large case series from a population-based registry. METHODS: The Surveillance, Epidemiology, and End Results database was used to report the clinical characteristics and incidence of SHMs in patients with PMGCT. RESULTS: Among 1297 PMGCTs, 27 cases (2...
October 19, 2023: American Journal of Clinical Oncology
https://read.qxmd.com/read/37848723/-18-f-fluorodeoxyglucose-positron-emission-tomography-computed-tomography-characteristics-of-primary-mediastinal-germ-cell-tumors
#23
JOURNAL ARTICLE
Koeun Lee, Yong-Il Kim, Jungsu S Oh, Seung Yeon Seo, Jae Kwang Yun, Geun Dong Lee, Sehoon Choi, Hyeong Ryul Kim, Yong-Hee Kim, Dong Kwan Kim, Seung-Il Park, Jin-Sook Ryu
Primary mediastinal germ cell tumor (MGCT) is an uncommon tumor. Although it has histology similar to that of gonadal germ cell tumor (GCT), the prognosis for MGCT is generally worse than that for gonadal GCT. We performed visual assessment and quantitative analysis of [18 F]fluorodeoxyglucose positron emission tomography/computed tomography ([18 F]FDG PET/CT) for MGCTs. A total of 35 MGCT patients (age = 33.1 ± 16.8 years, F:M = 16:19) who underwent preoperative PET/CT were retrospectively reviewed...
October 17, 2023: Scientific Reports
https://read.qxmd.com/read/37845684/a-massive-immature-mediastinal-teratoma-treated-with-chemotherapy-and-surgical-resection-a-case-report
#24
JOURNAL ARTICLE
Parviz Mardani, Hooman Kamran, Rezvan Ghaderpanah, Bita Geramizadeh, Damoun Fouladi, Reza Shahriarirad, Armin Amirian
BACKGROUND: Teratoma is a type of germ cell tumor consisting of one or multiple tissues derived from germinal layers. The location and size of the tumor can cause various presentations. Here we report one of the largest ever cases of immature cystic teratoma. CASE PRESENTATION: In this report, we presented a 24-year-old patient with dyspnea, chest pain, nausea, and anorexia. A computed tomography scan revealed a giant, right-sided mass measuring about 190 × 150 × 140 mm...
October 16, 2023: Journal of Cardiothoracic Surgery
https://read.qxmd.com/read/37734076/mediastinal-presentation-of-testicular-embryonal-carcinoma
#25
Sanyogita Chandra, Heidi McKean
Testicular embryonal carcinoma is a type of nonseminomatous germ cell tumor (NSGCT) that commonly presents with scrotal swelling due to testicular mass. About half of patients with NSGCTs will present with metastases at initial diagnosis. Rarely, testicular embryonal carcinoma can present primarily in the mediastinum. Treatment is well-studied and effective: chemotherapy with bleomycin, etoposide, and cisplatin. Post-chemotherapy retroperitoneal lymph node dissection (RPLND) is common adjuvant therapy. In this report we present a case of testicular embryonal carcinoma in a 32-year-old Caucasian man...
August 2023: South Dakota Medicine: the Journal of the South Dakota State Medical Association
https://read.qxmd.com/read/37721573/a-case-of-alpha-fetoprotein-positive-thymic-small-cell-carcinoma-a-case-report
#26
JOURNAL ARTICLE
Masao Kobayashi, Soichiro Funaki, Eriko Fukui, Eiichi Morii, Yasushi Shintani
BACKGROUND: An alpha-fetoprotein (AFP)-positive neuroendocrine tumor of the thymus is a rare thoracic malignancy. Few cases of AFP-positive thymic large cell neuroendocrine carcinoma have been reported, with no known previous report of an AFP-positive thymic small cell carcinoma. We encountered a patient with an AFP-positive small cell carcinoma and report here the clinical course. CASE PRESENTATION: A 40-year-old man was transferred to our hospital for a large anterior mediastinal tumor and showed an elevated serum AFP level...
September 18, 2023: Surgical Case Reports
https://read.qxmd.com/read/37667763/surgical-resection-in-patient-with-teratoma-with-somatic-type-malignancy-transformed-into-rhabdomyosarcoma-resulted-in-long-term-survival
#27
Junji Kitamura, Mitsuhiro Tambo, Ayano Nishijima, Kazuki Masuda, Jimpei Miyakawa, Yu Nakamura, Masachika Fujiwara, Takeshi Kishida, Hiroyuki Ito, Hiroshi Fukuhara
INTRODUCTION: Testicular germ cell tumors with somatic-type malignancy, wherein teratomas transform into sarcomas, is drug resistant and has a poor prognosis. CASE PRESENTATION: A 43-year-old man presented with a left testicular tumor, multiple pulmonary metastases, and mediastinal and para-aortic lymph node metastases. The testicular tumors were diagnosed as germ cell tumors. After bleomycin, etoposide, and cisplatin chemotherapy; right upper lobectomy for the pulmonary metastasis; and paclitaxel, ifosfamide, and cisplatin chemotherapy, rapidly progressing mediastinal lymph node metastasis was observed...
September 2023: IJU case reports
https://read.qxmd.com/read/37664539/refractory-primary-mediastinal-malignant-germ-cell-tumor-with-multiple-systemic-metastases-a-rare-case-report
#28
Xiaoli Chen, Mei Chen, Wenjing Zhang
The incidence of extra-gonadal germ cell tumor is low. There are few reports about liver metastasis and multiple systemic metastasis of mediastinal germ cell tumor. Here, we report a case of a 42-year-old young man with mediastinal mass discovered by computed tomography, which was finally confirmed as mediastinal germ cell tumor after many pathological biopsies. After radiotherapy and chemotherapy, the mediastinal mass was stable, but a new mass appeared in the liver. Mediastinal mass remained stable after modification of treatment regimen, but multiple metastases were found throughout the body...
September 2023: Urology Case Reports
https://read.qxmd.com/read/37577076/pure-mediastinal-seminoma-about-a-case-report
#29
Meriem Bouabid, Mohamed Moukhlissi, Ahmed Bensghir, Soumya Samba, Soufiane Berhili, Loubna Mezouar
Mediastinal Seminoma is one of the malignant germ cell tumors of the mediastinum. It is a rare tumor that represents only 1%-4% of mediastinal tumors. We report the case of a patient treated at the Oncology Center of Oujda for a pure primitive seminoma of the mediastinum, with a review of the literature to assess the epidemiological, clinical, therapeutic, and prognostic characteristics of this pathology. This is a 25-year-old man whose aunt is being treated for breast cancer and who complained of persistent dry cough with asthenia without any other associated signs...
October 2023: Radiology Case Reports
https://read.qxmd.com/read/37575730/a-challenging-case-of-heart-displacement-by-a-large-mediastinal-germ-cell-tumor
#30
Mohammed E Almalki, Mansour M Almalki, Mohammed A AlHarbi, Abdulkareem Nmnkany, Mona H Tayib, Fatma Aboul Enein, Saleh M Khouj
Mediastinal germ cell tumors (GCTs) are rare and aggressive cancers originating from the germ cells in the mediastinum. Early detection and treatment are vital due to their high potential for metastasis and recurrence. We present a case of a 28-year-old man who exhibited a cough and shortness of breath. Laboratory tests revealed elevated tumor markers, alpha-fetoprotein, and beta-human chorionic gonadotropin. Imaging studies displayed a large mediastinal mass, causing the right displacement of the mediastinum and cardiac tamponade...
July 2023: Curēus
https://read.qxmd.com/read/37524020/mediastinal-seminoma-in-a-pediatric-patient-managed-with-multi-modality-treatment-approach-a-case-report
#31
Waris Ahmad, Rida Wahab, Abdul Ahad Sohail
INTRODUCTION: Mediastinal seminomas arise due to abnormal migration of the totipotent stem cells during development. They occur very occasionally and makes up about 0.5-5 % of all mediastinal tumors. These usually occur in middle aged men, between 20 and 40 years. In pediatric age group, it is considered as an extremely rare finding, accounting for 3 %-7 % of all primary germ cell tumors. CASE PRESENTATION: We report a rare case of a 16-year-old boy with biopsy proven seminomatous type of germ cell tumor in anterior mediastinum who presented with productive cough and progressive dyspnea...
August 2023: International Journal of Surgery Case Reports
https://read.qxmd.com/read/37408409/-mediastinal-germ-cell-tumor-with-somatic-type-malignancy-report-of-a-case
#32
JOURNAL ARTICLE
J X Xu, C Y Guo, P Yuan, B Z Wang, Q Zhou, J M Ying
No abstract text is available yet for this article.
July 8, 2023: Zhonghua Bing Li Xue za Zhi Chinese Journal of Pathology
https://read.qxmd.com/read/37406535/a-rare-case-of-life-threatening-mixed-germ-cell-tumor-infiltrating-the-heart-a-case-report
#33
Muhammad Hilmy Ayundra, Navy Laksmono, Tri Wahyuni Murni
INTRODUCTION AND IMPORTANCE: Extragonadal germ cell tumors at the mediastinum are rare and comprise of 3-4 % of all germ cell tumors. Mixed GCTs can remain asymptomatic for long periods and often present with complications. We present a case of a young male patient with a mediastinal tumor infiltrating the heart and obstructing the right ventricular outflow tract, causing cardiogenic shock. CASE PRESENTATION: A 16-year-old male came with chief complain of shortness of breath and underwent an echocardiogram which revealed a mass in the right atrium and right ventricle...
June 9, 2023: International Journal of Surgery Case Reports
https://read.qxmd.com/read/37390229/teratomas-from-past-to-the-present-a-scientometric-analysis-with-global-productivity-and-research-trends-between-1980-and-2022
#34
REVIEW
Murat Çalbiyik, Sinan Zehir
There is currently no bibliometric study on teratomas in the literature. This study aims to analyze the published articles on teratomas to provide an overview of the subject, determine global productivity, and identify current research trends. Additionally, data on different components of scientific output (countries, journals, institutions, authors) were analyzed. A total of 4209 articles published on teratomas between 1980 and 2022 were analyzed using various bibliometric and statistical methods. Bibliometric network visualization maps were used to determine trending topics, citation analyses, and international collaborations...
June 30, 2023: Medicine (Baltimore)
https://read.qxmd.com/read/37228497/gene-mutation-landscape-of-a-rare-patient-with-acute-megakaryoblastic-leukemia-after-treatment-of-intracranial-germ-cell-tumor
#35
JOURNAL ARTICLE
Li-Xin Wang, Wei-Jie Liao, Yu-Hua Jiang, Chao Chen, Wang-Sheng Lu, Feng Yin, Hao-Yong Ning
INTRODUCTION: It was first reported that germ cell tumor patients suffer from hematologic malignancies 37 years ago. Since then, the number of relevant reports has increased each year, with most cases being mediastinal germ cell tumor. Theories have been proposed to explain this phenomenon, including a shared origin of progenitor cells, the effects of treatment, and independent development. However, up to now, no widely accepted explanation exists. The case with acute megakaryoblastic leukemia and intracranial germ cell tumor has never been reported before and the association is far less known...
2023: Frontiers in Oncology
https://read.qxmd.com/read/37222675/analysis-of-prognostic-factors-and-establishment-of-prognostic-model-for-primary-mediastinal-germ-cell-tumors-a-case-controlled-study
#36
JOURNAL ARTICLE
Changsen Leng, Yingying Cui, Zihang Mai, Rui Chen, Jianye Yuan, Kexi Wang, Jing Wen, Jianhua Fu, Qianwen Liu
BACKGROUND: The overall prognosis of primary mediastinal germ cell tumors (PMGCTs) is poor and the associated prognostic factors are not fully understood. Our goal was to investigate the prognostic factors of PMGCTs and to develop a validated prognostic prediction model. MATERIALS AND METHODS: A total of 114 PMGCTs with specific pathological types were included in this study. Clinicopathological characteristics of non-seminomatous PMGCTs and mediastinal seminomas were compared using Chi-square or Fisher's exact test...
May 24, 2023: International Journal of Surgery
https://read.qxmd.com/read/37160315/genomic-profiling-of-a-metastatic-anaplastic-melanocytic-neuroectodermal-tumor-arising-from-a-mature-thymic-teratoma-as-part-of-a-mediastinal-germ-cell-tumor
#37
JOURNAL ARTICLE
Sylvain Mayeur, Benoit Lhermitte, Justine Gantzer, Anne Molitor, Tristan Stemmelen, Sébastien Meyer, Aline Kolmer, Jean-Emmanuel Kurtz, Seiamak Bahram, Raphael Carapito
Following chemotherapy, a mediastinal germ cell tumor can lead to a mature teratoma that is composed of tissues derived from all three germ layers. Although teratoma is usually curable, in rare cases it can give rise to various somatic tumors and exceptionally it undergoes melanocytic neuroectodermal tumor (MNT) transformation, a process that is not well-described. We report a patient with a postchemotherapy thymic teratoma associated with an MNT component who, 10 years later, additionally presented a vertebral metastasis corresponding to an anaplastic MNT...
April 2023: Cold Spring Harbor Molecular Case Studies
https://read.qxmd.com/read/37143945/clinical-radiomics-based-machine-learning-versus-three-dimension-convolutional-neural-network-analysis-for-differentiation-of-thymic-epithelial-tumors-from-other-prevascular-mediastinal-tumors-on-chest-computed-tomography-scan
#38
JOURNAL ARTICLE
Chao-Chun Chang, En-Kuei Tang, Yu-Feng Wei, Chia-Ying Lin, Fu-Zong Wu, Ming-Ting Wu, Yi-Sheng Liu, Yi-Ting Yen, Mi-Chia Ma, Yau-Lin Tseng
PURPOSE: To compare the diagnostic performance of radiomic analysis with machine learning (ML) model with a convolutional neural network (CNN) in differentiating thymic epithelial tumors (TETs) from other prevascular mediastinal tumors (PMTs). METHODS: A retrospective study was performed in patients with PMTs and undergoing surgical resection or biopsy in National Cheng Kung University Hospital, Tainan, Taiwan, E-Da Hospital, Kaohsiung, Taiwan, and Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan between January 2010 and December 2019...
2023: Frontiers in Oncology
https://read.qxmd.com/read/37102022/a-rare-case-of-rapidly-progressive-extragonadal-mature-cystic-teratoma-presenting-with-chest-pain
#39
Ayman Mohamed, Lisa De Rose, Talal Bazzi, Mark Benjamin
Mature cystic teratomas represent the most prevalent subtype of germ cell tumors affecting the ovaries. Typically, these neoplasms are benign and characterized by a slow growth pattern. Nevertheless, malignant transformation of these tumors is a rare event that may occur. Despite their typically indolent behavior, some cases may exhibit rapid growth rates and give rise to a variety of complications, including rupture and consequent manifestation of a wide range of clinical signs and symptoms. This report details the case of a 49-year-old woman who presented to the hospital with a chief complaint of chest pain...
March 2023: Curēus
https://read.qxmd.com/read/37095824/mediastinal-teratoma-mimicking-neurofibroma-in-ct-guided-biopsy-in-a-patient-with-neurofibromatosis-type-1
#40
Andreas Gkikas, Sofoklis Mitsos, Achilleas Antonopoulos, Nikolaos Korodimos, Elias Santaitidis, Nektarios Koufopoulos, Alina-Roxani Gouloumis, Periklis Tomos
Teratomas are a type of germ cell tumor that may contain several different types of tissue. Neurofibroma is a benign peripheral nerve sheath tumor with the plexiform type being pathognomonic for neurofibromatosis type 1. We report a case of a 33-year-old woman with a background of Neurofibromatosis type 1 who presented with left-sided chest pain and shortness of breath. She was diagnosed with a large mediastinal mass which was confirmed from a CT-guided biopsy as neurofibroma. Following a multidisciplinary team discussion, she underwent mediastinal mass resection and the final histopathology report revealed mediastinal mature teratoma...
March 2023: Curēus
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