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Mediastinal germ cell tumor

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https://www.readbyqxmd.com/read/30022915/usefulness-of-plain-computed-tomography-with-swallowing-of-gastrografin-tm-for-the-diagnosis-of-a-late-onset-iatrogenic-diaphragmatic-hernia-following-biopsy-of-a-diaphragmatic-tumor-report-of-a-case
#1
Yoh Asahi, Shohei Honda, Tadao Okada, Hisayuki Miyagi, Makoto Kaneda, Akihiro Iguchi, Kichizo Kaga, Akinobu Taketomi
Although diaphragmatic hernia (DH) may be congenital, posttraumatic, or iatrogenic, DHs after diaphragmatic surgery are rarely reported in the literature. This report describes the rare case of a 14-year-old girl complicated by iatrogenic DH following the biopsy of granulomatous lesions of the left diaphragm, when a mediastinal mixed germ cell tumor was extirpated. Plain computed tomography (CT) with swallowing of GastrografinTM was useful for the diagnosis of this disorder. The patient presented to our hospital with frequent epigastric pain and vomiting 11 months after the original surgery...
May 2018: Case Reports in Gastroenterology
https://www.readbyqxmd.com/read/30004909/retroperitoneal-lymph-node-dissection-in-the-setting-of-elevated-markers
#2
Jale Lakes, Achim Lusch, Alessandro Nini, Peter Albers
PURPOSE OF REVIEW: The management of residual tumor masses in patients with metastatic germ cell tumor and persistently elevated tumor marker levels after first- and second-line chemotherapy usually excludes surgical resection. The lack of benefit of salvage chemotherapy in patients with persistently elevated markers implies a degree of chemotherapy resistance. However, previous studies demonstrated therapeutic efficacy for a surgical approach in these very particular patients. Therefore, we evaluated pre and postoperative factors, which help to identify suitable candidates, who could potentially benefit from tumor resection...
July 12, 2018: Current Opinion in Urology
https://www.readbyqxmd.com/read/29913128/granulocytic-sarcoma-and-mediastinal-germ-cell-tumor-a-common-cell-of-origin
#3
Sarbajit Mukherjee, Sami Ibrahimi, Teresa Scordino, Mohamad Cherry
No abstract text is available yet for this article.
June 15, 2018: Hematology/oncology and Stem Cell Therapy
https://www.readbyqxmd.com/read/29864110/hematologic-malignancies-associated-with-mediastinal-germ-cell-tumors-10-years-experience-at-thailand-s-national-pediatric-tertiary-referral-center
#4
Panjarat Sowithayasakul, Phakatip Sinlapamongkolkul, Jitsupa Treetipsatit, Nassawee Vathana, Nattee Narkbunnam, Kleebsabai Sanpakit, Jassada Buaboonnam
Mediastinal germ cell tumor (MGCT), which accounts for 1% to 3% of extragonadal germ cell tumors, has unique manifestations; it is associated with several types of hematologic malignancy, particularly myeloid neoplasm. The aim of this study was to report the 10-year incidence, clinical characteristics, and outcomes of MGCT at Thailand's national pediatric tertiary referral center. This retrospective study included patients diagnosed with MGCT at the Department of Pediatrics, Siriraj Hospital during 2005 to 2014...
June 1, 2018: Journal of Pediatric Hematology/oncology
https://www.readbyqxmd.com/read/29753846/role-of-hnf1%C3%AE-in-the-differential-diagnosis-from-other-germ-cell-tumors
#5
Anne-Laure Rougemont, Jean-Christophe Tille
Identification of the yolk sac tumor (YST) component in germ cell tumors (GCT) may prove challenging, and highly sensitive and specific immunohistochemical markers are still lacking. Preliminary data from the literature suggest that HNF1β may represent a sensitive marker of YST. The specificity of HNF1β has not been addressed in GCT. A cohort of 49 YST specimens from 45 patients was designed, occurring either as pure tumors, or as a component of a mixed GCT. Immunohistochemistry was conducted on whole tumor sections using HNF1β...
May 10, 2018: Human Pathology
https://www.readbyqxmd.com/read/29751199/intrapericardial-gossypiboma-rare-cause-of-intrathoracic-mass
#6
Anil Kumar, Shiv Shankar Paswan, Rajinder Prashad, Rekha Kumari, Bindey Kumar
INTRODUCTION: Gossypiboma is a retained surgical sponge inside our body after surgical intervention. It is most commonly found in abdominal cavity. Its occurrence in thoracic cavity as intrapericardial gossypiboma is extremely rare. PRESENTATION OF CASE: We present a 25 year old male with complaint of chest pain for 1 year. He had a history of total correction of Tetralogy of fallot 14 years back, at another hospital. On clinical examination and investigations including contrast enhanced computed tomography (CECT) of thorax; diagnosis of right anterior mediastinal mass of germ cell tumor was made and planned for thoracotomy...
2018: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/29739439/immature-teratoma-mimicking-pulmonary-stenosis-a-case-report
#7
Dardan Koçinaj, Xhevdet Krasniqi, Aurora Bakalli
BACKGROUND: Immature teratoma in a mediastinal location is a rare disease that might present as a valve pathology. Germ cell tumors with mediastinal locations account for up to 6% of immature teratoma cases. We present a case of an immature teratoma located primarily in the anterior mediastinum that manifested solely through symptoms of pulmonary stenosis. CASE PRESENTATION: We report a case of a 20-year-old white man with an immature teratoma who presented with progressive exertional dyspnea...
May 9, 2018: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/29515979/thymic-teratoma-presenting-as-non-immune-hydrops-fetalis
#8
Ameer Hamza, Eleftherios Vouyoukas, Ian Jacob Anderson, Martha Jaye Higgins
Teratomas are one of the most frequent tumors in the pediatric population. They occur anywhere along the midline of the body, following the course of the embryonic germ cell ridge. In the mediastinal location, they exert space occupying effects, leading to a myriad of complications, including non-immune hydrops fetalis. We describe a fatal case of an immature thymic teratoma in a neonate presenting with hydrops fetalis. This case emphasizes the importance of early diagnosis and surgical intervention in such cases...
January 2018: Autopsy & Case Reports
https://www.readbyqxmd.com/read/29506496/extragonadal-germ-cell-tumor-of-the-posterior-mediastinum-in-a-child-complicated-with-spinal-cord-compression-a-case-report
#9
Dong Keon Yon, Tae Keun Ahn, Dong Eun Shin, Gwang Il Kim, Moon Kyu Kim
BACKGROUND: Germ cell tumors (GCTs) in children are rare neoplasms with diverse pathological findings according to the site and age of presentation. The most common symptoms in children with mediastinal GCTs, which are nonspecific, are dyspnea, chest pain, cough, hemoptysis, vena cava occlusion syndrome, and fatigue/weakness. Because of these nonspecific symptoms, it is difficult to suspect a mediastinal mass. A posterior mediastinal tumor causing spinal cord compression is an important example of an oncologic emergency arising from a neurogenic tumor...
March 5, 2018: BMC Pediatrics
https://www.readbyqxmd.com/read/29390446/hepatic-angiosarcomatous-transformation-of-a-mediastinal-germinal-cell-tumor-a-care-case-report
#10
Giuseppe Corrias, Joanna G Escalon, Laura Tang, Serena Monti, Luca Saba, Lorenzo Mannelli
RATIONALE: Mediastinal nonseminomatous germ cell tumor (NSGCT) is an uncommon entity. Metastatic hepatic sarcomatous transformation is rare. PATIENT CONCERNS: We report a 24-year-old man with no previous related medical history presented with chest pain and left arm numbness. DIAGNOSES: The x-ray showed an anterior mediastinal mass. The chest computed tomography (CT) confirmed the presence of a mildly enhancing mass in the same location, without invasion of any vascular structure...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29332656/germ-cell-tumor-causing-pleural-effusion-a-diagnostic-dilemma
#11
Surabhi Jaggi, Reetu Kundu, Sanjeev Binji, Uma Handa, Varinder Saini
Straw colored pleural fluid with raised adenosine deaminase (ADA) levels in young healthy adults usually raises suspicion of tuberculosis, sometimes leading to laxity in carrying thorough physical examination and missing out some important clues with potential disastrous consequences. A 35-year-old male was diagnosed to have left pleural effusion and anti-tubercular treatment was started on the basis of straw colored, lymphocyte-predominant pleural fluid with significantly raised ADA levels. When there was no improvement after 1 month of treatment he was investigated further and found to have a mediastinal mass along with hydro-pneumothorax...
January 2018: Indian Journal of Tuberculosis
https://www.readbyqxmd.com/read/29318787/primary-mediastinal-yolk-sac-tumor-treated-with-platinum-based-chemotherapy-and-extended-resection-report-of-seven-cases
#12
Bing Liu, Gang Lin, Jingwei Liu, Haibo Liu, Xueqian Shang, Jian Li
BACKGROUND: Primary mediastinal yolk sac tumor, which is also known as endodermal sinus tumor, is a rare but lethal neoplasm, and it is a kind of mediastinal non-seminomatous germ cell tumor. The current standard treatment in mediastinal non-seminomatous germ cell tumors is chemotherapy combined with postchemotherapy residual mass resection. We report on seven cases of primary mediastinal yolk sac tumor treated with platinum-based chemotherapy and extended resection. METHODS: We experienced seven cases of primary mediastinal yolk sac tumor between August 2014 and August 2017...
April 2018: Thoracic Cancer
https://www.readbyqxmd.com/read/29146413/ct-fluoroscopy-guided-core-needle-biopsy-of-anterior-mediastinal-masses
#13
T Iguchi, T Hiraki, Y Matsui, H Fujiwara, J Sakurai, Y Masaoka, M Uka, T Tanaka, H Gobara, S Kanazawa
OBJECTIVE: To retrospectively evaluate the safety, diagnostic yield, and risk factors of diagnostic failure of computed tomography (CT) fluoroscopy-guided biopsies of anterior mediastinal masses. MATERIALS AND METHODS: Biopsy procedures and results of anterior mediastinal masses in 71 patients (32 women/39 men; mean [±standard deviation] age, 53.8±20.0years; range, 14-88years) were analyzed. Final diagnoses were based on surgical outcomes, imaging findings, or clinical follow-up findings...
February 2018: Diagnostic and Interventional Imaging
https://www.readbyqxmd.com/read/29106050/radiological-pathological-correlation-of-malignant-teratoma-with-liposarcomatous-transformation-proven-by-repeated-transthoracic-needle-biopsy
#14
Hyo-Jae Lee, Hyun Ju Seon, Yoo-Duk Choi
A mediastinal germ cell tumor with a sarcomatous component is extremely rare and is accompanied by a poor prognosis. Clinical and radiologic diagnosis is very difficult. Herein, we report a rare case of anterior mediastinal malignant teratoma containing a growing liposarcomatous component and detail the diagnostic process. The case was diagnosed by repeated transthoracic needle biopsy and correlated with changes in follow-up chest computed tomography and serum tumor markers. We also provide a review of the literature...
January 2018: Thoracic Cancer
https://www.readbyqxmd.com/read/29071000/burned-out-testicular-cancer-really-a-different-history
#15
Claudia Mosillo, Simone Scagnoli, Giulia Pomati, Salvatore Caponnetto, Maria Laura Mancini, Mario Bezzi, Enrico Cortesi, Alain Gelibter
Two or more histological types characterize more than 60% of testicular germ cell tumors (GCTs). Burned-out testicular tumor refers to partial or complete histological regression of the primary testicular lesions. The most frequent GCT type involved in this kind of histological regression is choriocarcinoma, followed by embryonal carcinoma. To our knowledge, there are no cases of the burned-out phenomenon in teratoma. We report a case of a 19-year-old man presenting to our institute with a right testicular lesion, evidence of mediastinal and abdominal lymph node metastasis, and high levels of GCT serum biomarkers...
September 2017: Case Reports in Oncology
https://www.readbyqxmd.com/read/29037532/prediction-of-respiratory-collapse-among-pediatric-patients-with-mediastinal-tumors-during-induction-of-general-anesthesia
#16
Yunosuke Kawaguchi, Takeshi Saito, Tetsuya Mitsunaga, Keita Terui, Mitsuyuki Nakata, Gen Matsuura, Katsunori Kouchi, Hideo Yoshida
PURPOSE: Fatality resulting from respiratory collapse (RC) during general anesthesia (GA) induction in children with mediastinal tumors has been reported. We explored potentially useful parameters for predicting the risk of RC based on objective imaging results. METHODS: We retrospectively reviewed the records of 31 patients (median age: 4years; range: 4months-15years) with mediastinal tumors treated between 2000 and 2015. Comparing those with RC under GA induction to those without (RC group vs...
October 2, 2017: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/29032518/synchronous-solitary-calvarial-yolk-sac-tumor-metastasis-as-the-initial-presentation-of-mediastinal-germ-cell-tumor
#17
Kirti Gupta, Madhivanan Karthigeyan, Ayushman Satapathy, Pravin Salunke
INTRODUCTION: In children, malignant tumors presenting as a calvarial mass that too as initial manifestation are unusual. Also, brain metastases per se are rare in pediatric solid tumors with an incidence of just 1.5%. CASE DESCRIPTION: We present a child with calvarial metastasis which was the presenting symptom of an otherwise asymptomatic large malignant mediastinal germ cell tumor (GCT). The lesion was dural-based involving both calvaria as well as the underlying brain parenchyma...
February 2018: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://www.readbyqxmd.com/read/28954036/yolk-sac-primary-tumor-of-mediastino-a-rare-case-in-a-young-adult
#18
Lorena Luryann Cartaxo da Silva, Fernanda Sasaki Vergilio, Diva Carvalho Collarile Yamaguti, Isabela Azevedo Nicodemos da Cruz, Joana Angrisani Granato Queen
Germ cell tumors are rare neoplasms that mostly occur in the gonads, although they can also affect other body sites, especially the anterior mediastinum (50 to 70% of all extragonadal germ cell tumors). We report a case of a primary mediastinal yolk sac tumor, a rare and aggressive germ cell tumors subtype. This was a 38-year-old man who was admitted to Hospital do Servidor Público Estadual "Francisco Morato de Oliveira", complaining about dyspnea and dry cough for 1 year. The computed tomography scan of his chest revealed a large mass in the anterior mediastinum with heterogeneous enhancement to the contrast associated with pleural effusion...
October 2017: Einstein
https://www.readbyqxmd.com/read/28938687/mediastinal-lesions-across-the-age-spectrum-a-clinicopathological-comparison-between-pediatric-and-adult-patients
#19
Tingting Liu, Lika'a Fasih Y Al-Kzayer, Xiao Xie, Hua Fan, Shamil Naji Sarsam, Yozo Nakazawa, Lei Chen
The objective of this study was to identify the differences in histopathological distribution and clinical features of mediastinal lesions (MLs) across the age spectrum in Chinese series of patients and to compare with the available literature. A total of 409 cases of MLs, including 137 pediatric and 272 adult patients from a single institution, was reviewed and categorized into groups according to age. Among the 409 cases, the age showed a bimodal distribution with an increased incidence of MLs among (< 10 year) and (60-< 70 year) age groups...
August 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/28921451/distribution-of-malignant-lymphomas-in-the-anterior-mediastinum-a-single-institution-study-of-76-cases-in-japan-1997-2016
#20
Akiko Miyagi Maeshima, Hirokazu Taniguchi, Tomotaka Suzuki, Sayako Yuda, Kosuke Toyoda, Nobuhiko Yamauchi, Shinichi Makita, Suguru Fukuhara, Wataru Munakata, Dai Maruyama, Yukio Kobayashi, Kensei Tobinai
We analyzed the distribution of tumors and lymphomas of the anterior mediastinum diagnosed between 1997 and 2016 at the National Cancer Center Hospital, Japan. The median age of 283 patients with anterior mediastinal tumors was 48 (range 6-84) years, and 143 (51%) were male. The incidence of tumors was as follows: thymoma, 34%; thymic carcinoma, 16%; primary mediastinal large B-cell lymphoma (PMBL), 13%; germ cell tumors, 10%; classical Hodgkin lymphoma (CHL), 9%; thymic cyst, 7%; metastatic tumors, 3%; T lymphoblastic leukemia/lymphoma (T-LBL), 2%; other lymphomas, 3%; and others, 3%...
November 2017: International Journal of Hematology
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