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Mediastinal germ cell tumor

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https://www.readbyqxmd.com/read/29146413/ct-fluoroscopy-guided-core-needle-biopsy-of-anterior-mediastinal-masses
#1
T Iguchi, T Hiraki, Y Matsui, H Fujiwara, J Sakurai, Y Masaoka, M Uka, T Tanaka, H Gobara, S Kanazawa
OBJECTIVE: To retrospectively evaluate the safety, diagnostic yield, and risk factors of diagnostic failure of computed tomography (CT) fluoroscopy-guided biopsies of anterior mediastinal masses. MATERIALS AND METHODS: Biopsy procedures and results of anterior mediastinal masses in 71 patients (32 women/39 men; mean [±standard deviation] age, 53.8±20.0years; range, 14-88years) were analyzed. Final diagnoses were based on surgical outcomes, imaging findings, or clinical follow-up findings...
November 13, 2017: Diagnostic and Interventional Imaging
https://www.readbyqxmd.com/read/29106050/radiological-pathological-correlation-of-malignant-teratoma-with-liposarcomatous-transformation-proven-by-repeated-transthoracic-needle-biopsy
#2
Hyo-Jae Lee, Hyun Ju Seon, Yoo-Duk Choi
A mediastinal germ cell tumor with a sarcomatous component is extremely rare and is accompanied by a poor prognosis. Clinical and radiologic diagnosis is very difficult. Herein, we report a rare case of anterior mediastinal malignant teratoma containing a growing liposarcomatous component and detail the diagnostic process. The case was diagnosed by repeated transthoracic needle biopsy and correlated with changes in follow-up chest computed tomography and serum tumor markers. We also provide a review of the literature...
November 6, 2017: Thoracic Cancer
https://www.readbyqxmd.com/read/29071000/burned-out-testicular-cancer-really-a-different-history
#3
Claudia Mosillo, Simone Scagnoli, Giulia Pomati, Salvatore Caponnetto, Maria Laura Mancini, Mario Bezzi, Enrico Cortesi, Alain Gelibter
Two or more histological types characterize more than 60% of testicular germ cell tumors (GCTs). Burned-out testicular tumor refers to partial or complete histological regression of the primary testicular lesions. The most frequent GCT type involved in this kind of histological regression is choriocarcinoma, followed by embryonal carcinoma. To our knowledge, there are no cases of the burned-out phenomenon in teratoma. We report a case of a 19-year-old man presenting to our institute with a right testicular lesion, evidence of mediastinal and abdominal lymph node metastasis, and high levels of GCT serum biomarkers...
September 2017: Case Reports in Oncology
https://www.readbyqxmd.com/read/29037532/prediction-of-respiratory-collapse-among-pediatric-patients-with-mediastinal-tumors-during-induction-of-general-anesthesia
#4
Yunosuke Kawaguchi, Takeshi Saito, Tetsuya Mitsunaga, Keita Terui, Mitsuyuki Nakata, Gen Matsuura, Katsunori Kouchi, Hideo Yoshida
PURPOSE: Fatality resulting from respiratory collapse (RC) during general anesthesia (GA) induction in children with mediastinal tumors has been reported. We explored potentially useful parameters for predicting the risk of RC based on objective imaging results. METHODS: We retrospectively reviewed the records of 31 patients (median age: 4years; range: 4months-15years) with mediastinal tumors treated between 2000 and 2015. Comparing those with RC under GA induction to those without (RC group vs...
October 2, 2017: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/29032518/synchronous-solitary-calvarial-yolk-sac-tumor-metastasis-as-the-initial-presentation-of-mediastinal-germ-cell-tumor
#5
Kirti Gupta, Madhivanan Karthigeyan, Ayushman Satapathy, Pravin Salunke
INTRODUCTION: In children, malignant tumors presenting as a calvarial mass that too as initial manifestation are unusual. Also, brain metastases per se are rare in pediatric solid tumors with an incidence of just 1.5%. CASE DESCRIPTION: We present a child with calvarial metastasis which was the presenting symptom of an otherwise asymptomatic large malignant mediastinal germ cell tumor (GCT). The lesion was dural-based involving both calvaria as well as the underlying brain parenchyma...
October 14, 2017: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://www.readbyqxmd.com/read/28954036/yolk-sac-primary-tumor-of-mediastino-a-rare-case-in-a-young-adult
#6
Lorena Luryann Cartaxo da Silva, Fernanda Sasaki Vergilio, Diva Carvalho Collarile Yamaguti, Isabela Azevedo Nicodemos da Cruz, Joana Angrisani Granato Queen
Germ cell tumors are rare neoplasms that mostly occur in the gonads, although they can also affect other body sites, especially the anterior mediastinum (50 to 70% of all extragonadal germ cell tumors). We report a case of a primary mediastinal yolk sac tumor, a rare and aggressive germ cell tumors subtype. This was a 38-year-old man who was admitted to Hospital do Servidor Público Estadual "Francisco Morato de Oliveira", complaining about dyspnea and dry cough for 1 year. The computed tomography scan of his chest revealed a large mass in the anterior mediastinum with heterogeneous enhancement to the contrast associated with pleural effusion...
September 21, 2017: Einstein
https://www.readbyqxmd.com/read/28938687/mediastinal-lesions-across-the-age-spectrum-a-clinicopathological-comparison-between-pediatric-and-adult-patients
#7
Tingting Liu, Lika'a Fasih Y Al-Kzayer, Xiao Xie, Hua Fan, Shamil Naji Sarsam, Yozo Nakazawa, Lei Chen
The objective of this study was to identify the differences in histopathological distribution and clinical features of mediastinal lesions (MLs) across the age spectrum in Chinese series of patients and to compare with the available literature. A total of 409 cases of MLs, including 137 pediatric and 272 adult patients from a single institution, was reviewed and categorized into groups according to age. Among the 409 cases, the age showed a bimodal distribution with an increased incidence of MLs among (< 10 year) and (60-< 70 year) age groups...
August 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/28921451/distribution-of-malignant-lymphomas-in-the-anterior-mediastinum-a-single-institution-study-of-76-cases-in-japan-1997-2016
#8
Akiko Miyagi Maeshima, Hirokazu Taniguchi, Tomotaka Suzuki, Sayako Yuda, Kosuke Toyoda, Nobuhiko Yamauchi, Shinichi Makita, Suguru Fukuhara, Wataru Munakata, Dai Maruyama, Yukio Kobayashi, Kensei Tobinai
We analyzed the distribution of tumors and lymphomas of the anterior mediastinum diagnosed between 1997 and 2016 at the National Cancer Center Hospital, Japan. The median age of 283 patients with anterior mediastinal tumors was 48 (range 6-84) years, and 143 (51%) were male. The incidence of tumors was as follows: thymoma, 34%; thymic carcinoma, 16%; primary mediastinal large B-cell lymphoma (PMBL), 13%; germ cell tumors, 10%; classical Hodgkin lymphoma (CHL), 9%; thymic cyst, 7%; metastatic tumors, 3%; T lymphoblastic leukemia/lymphoma (T-LBL), 2%; other lymphomas, 3%; and others, 3%...
November 2017: International Journal of Hematology
https://www.readbyqxmd.com/read/28906275/vv-ecmo-assisted-high-risk-endobronchial-stenting-as-rescue-for-asphyxiating-mediastinal-mass
#9
Brandon T Nokes, Laszlo Vaszar, Jama Jahanyar, Karen L Swanson
The use of venovenous extracorporeal membrane oxygenation (VV-ECMO) has traditionally been limited to a narrow set of clinical circumstances, such as acute hypoxic respiratory failure, submassive pulmonary embolism, and cardiopulmonary collapse. Within the pediatric population, there have been cases of VV-ECMO in the context of extrinsic airway compression by a mediastinal mass, typically in the setting of either a lymphoma or germ cell tumors. However, the use of VV-ECMO for adults with extrinsic airway compression is comparatively limited...
September 12, 2017: Journal of Bronchology & Interventional Pulmonology
https://www.readbyqxmd.com/read/28900334/massive-hemoptysis-a-rare-presentation-of-anterior-mediastinal-teratoma-in-an-adolescent
#10
Rajkumar M Meshram, S Abhisheik, Vaidehi Hardas, K Siddharth
Germ cell tumors are predominantly found in the gonads, and the most common extragonadal site is anterior mediastinum. Usual symptoms are cough, dyspnea, and fever, chest pain due to mass effect or intrapulmonary invasion but hemoptysis is rare and may result from either communication with tracheobronchial tree or may result from bronchial bleeding due to irritation by tumor. As in our case, patient presenting with massive hemoptysis and shock are the rarest presentation of a benign teratoma.
April 2017: Indian Journal of Medical and Paediatric Oncology
https://www.readbyqxmd.com/read/28889760/an-analysis-of-clinical-characteristics-and-patient-outcomes-in-primary-mediastinal-sarcomas
#11
Omar Abdel-Rahman
BACKGROUND: Published data concerning primary mediastinal sarcomas are limited to small-sized retrospective series.  This study reviewed the clinical outcomes of these cases from the SEER (surveillance, epidemiology and end results) database. METHODS: Primary mediastinal sarcomas (1988 - 2013) were assembled from the SEER database. The incidence and 10-year cancer-specific survival rates were compared to other primary mediastinal malignancies (thymic carcinoma, germ cell tumors, neurogenic tumors, Hodgkin / non Hodgkin lymphomas) as well as to non mediastinal sarcomas...
November 2017: Expert Review of Anticancer Therapy
https://www.readbyqxmd.com/read/28888750/primary-mediastinal-pure-seminomatous-germ-cell-tumor-germinoma-as-a-rare-cause-of-precocious-puberty-in-a-9-year-old-patient
#12
Alejandra Bravo-Balado, Lynda Torres Castellanos, Adriana Carrillo Rodríguez, Daniel Gómez Zapata, Juan Javier Lammoglia Hoyos, Rafael Andrade, Jaime Pérez Niño
Less than 5%-7% of germ cell tumors are extragonadal, with the central nervous system being the most common location in children, followed by retroperitoneum and mediastinum. Only 10% of mediastinal tumors are malignant and one-third of these are pure seminomas (germinomas). We report the case of a 9-year-old boy with development of secondary sexual characteristics. Beta-human chorionic gonadotropin was elevated and a mediastinal mass was found. Final histology showed a pure seminomatous germ cell tumor. To our knowledge, this is the first report of a boy with precocious puberty secondary to a mediastinal germinoma...
September 6, 2017: Urology
https://www.readbyqxmd.com/read/28844590/surgical-approaches-anaesthetic-management-and-outcome-in-pediatric-superior-mediastinal-tumors
#13
Gehad Ahmed, Mohammed M Hegazy, Tarek Raafat, Hanafy Hafez, Sayed Fadel, Maged Elshafiey
BACKGROUND: Pediatric superior mediastinal tumors are a heterogeneous group of tumors with marked variation in pathology and extension. We reviewed our experience with different surgical approaches to tumors originating from or extending to superior mediastinum in pediatrics. PATIENTS AND METHODS: The medical records of all patients who had undergone resection for superior mediastinal tumors in Children's Cancer Hospital - Egypt, between January 2008 to December 2015, were reviewed for demographic data, clinico-pathological features, radiologic findings, operative techniques and outcome...
August 22, 2017: Journal of the Egyptian National Cancer Institute
https://www.readbyqxmd.com/read/28819093/non-seminomatous-germ-cell-tumor-presenting-with-superior-vena-cava-syndrome
#14
Paolo K Soriano, Muhammad F Iqbal, Omar M Siddiqui, Jeff F Wang, Meghna R Desai
BACKGROUND Primary mediastinal non-seminomatous germ cell tumors (NSGCTs) are aggressive and carry a poor five-year disease free survival rate even with aggressive treatment. We describe a young adult male with primary mediastinal NSGCT presenting with airway obstruction and superior vena cava syndrome (SVCS). CASE REPORT The patient presented with four weeks of nonproductive cough, weight loss, and right-sided pleuritic chest pain. Chest computed topography (CT) imaging demonstrated a right-sided mediastinal mass determined as a yolk sac tumor on biopsy...
August 18, 2017: American Journal of Case Reports
https://www.readbyqxmd.com/read/28813488/role-of-post-chemotherapy-radiation-in-the-management-of-children-and-adolescents-with-primary-advanced-malignant-mediastinal-germ-cell-tumors
#15
Junting Huang, Yuting Tan, Zijun Zhen, Suying Lu, Feifei Sun, Jia Zhu, Juan Wang, Ru Liao, Xiaofei Sun
OBJECTIVE: Primary malignant mediastinal germ cell tumors (MMGCTs) are rare in children and adolescents and have a poorer prognosis than their gonadal counterparts. We report a single institutional experience of a 10-year period of primary advanced MMGCTs treated with chemotherapy, followed by radiotherapy in those who had residual mass. METHODS: Children and adolescents with primary advanced MMGCTs between 2005 and 2014 were identified from the Cancer Center, Sun Yat-Sen University...
2017: PloS One
https://www.readbyqxmd.com/read/28638160/low-flow-extracorporeal-carbon-dioxide-removal-using-the-hemolung-respiratory-dialysis-system-%C3%A2-to-facilitate-lung-protective-mechanical-ventilation-in-acute-respiratory-distress-syndrome
#16
Bindu Akkanti, Keshava Rajagopal, Kirti P Patel, Sangeeta Aravind, Emmanuel Nunez-Centanu, Rahat Hussain, Farshad Raissi Shabari, Wayne L Hofstetter, Ara A Vaporciyan, Igor S Banjac, Biswajit Kar, Igor D Gregoric, Pranav Loyalka
Extracorporeal carbon dioxide removal (ECCO2R) permits reductions in alveolar ventilation requirements that the lungs would otherwise have to provide. This concept was applied to a case of hypercapnia refractory to high-level invasive mechanical ventilator support. We present a case of an 18-year-old man who developed post-pneumonectomy acute respiratory distress syndrome (ARDS) after resection of a mediastinal germ cell tumor involving the left lung hilum. Hypercapnia and hypoxemia persisted despite ventilator support even at traumatic levels...
June 2017: Journal of Extra-corporeal Technology
https://www.readbyqxmd.com/read/28634489/a-study-of-patients-with-primary-mediastinal-germ-cell-tumors-treated-using-multimodal-therapy
#17
Yutaro Tanaka, Takehiko Okamura, Takashi Nagai, Daichi Kobayashi, Takahiro Kobayashi, Hidetoshi Akita, Yoshinobu Moritoki, Takahiro Yasui
OBJECTIVES: Primary mediastinal germ cell tumors (PMGCTs) are rare, which often makes them difficult to treat. Herein, we examined patients with PMGCTs who underwent multimodal treatment. METHODS: We examined 6 patients (median age: 25 years, range: 19-27 years) with PMGCTs who underwent multimodal treatment between April 2001 and March 2015. Three patients had seminomas, 2 patients had yolk sac tumors, and 1 patient had choriocarcinoma. The median observation period was 32...
2017: Advances in Urology
https://www.readbyqxmd.com/read/28595223/-successful-combined-modality-therapy-for-an-advanced-malignant-mediastinal-non-seminomatous-germ-cell-tumor-in-an-elderly-female
#18
Hirotoshi Suzuki, Osamu Araki, Muneo Minowa, Yoshifumi Matsuura, Yuji Matsumura
A 69-year-old woman was diagnosed with a germ cell tumor in the anterior mediastinum. Following 3 years follow-up, she experienced chest pain and an enlarging of the anterior mediastinal tumor and bilateral lung metastases were detected by chest X-ray. The tumor was diagnosed as a primary malignant mediastinal non-seminomatous germ cell tumor by needle biopsy. After initial radiotherapy (12 Gy/4 Fr), she was subsequently treated with EP chemotherapy which achieved a partial response. Complete resection of the residual tumors in the mediastinum and right lung was performed...
June 2017: Kyobu Geka. the Japanese Journal of Thoracic Surgery
https://www.readbyqxmd.com/read/28578457/non-seminomatous-mediastinal-germ-cell-tumor-and-acute-megakaryoblastic-leukemia
#19
REVIEW
Sarbajit Mukherjee, Sami Ibrahimi, Sonia John, Mohammed Muqeet Adnan, Teresa Scordino, Mohammad O Khalil, Mohamad Cherry
The association between mediastinal germ cell tumors (MGCT) and acute megakaryoblastic (M7) leukemia has been known for many years. We hereby present this review to better characterize the coexistence of these entities as well as the salient features, the treatment options, and the overall prognosis. A search of PUBMED, Medline, and EMBASE databases via OVID engine for primary articles and case reports under keywords "germ cell tumors" and "acute myeloid leukemia" revealed a total of 26 cases in English that reported MGCT and M7 leukemia...
September 2017: Annals of Hematology
https://www.readbyqxmd.com/read/28540630/surgery-for-malignant-lesions-of-the-chest-which-extensively-involved-the-mediastinum-lung-and-heart
#20
REVIEW
Yugo Tanaka, Daisuke Hokka, Hiroyuki Ogawa, Nahoko Shimizu, Takeshi Inoue, Hiroshi Tanaka, Yutaka Okita, Yoshimasa Maniwa
OBJECTIVE: Radical resection for thoracic malignancies that invade the great vessels or heart structure is an uncommon, high-risk operation. To help surgeons determine therapeutic strategy, we reviewed the patient characteristics and outcomes of combined thoracic and cardiovascular surgery for thoracic malignancies. METHODS: Surgical resections of lung cancer, mediastinal tumor and pulmonary artery sarcoma invading great vessels or heart structures were reviewed from the literature...
July 2017: General Thoracic and Cardiovascular Surgery
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