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Mediastinal germ cell tumor

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https://www.readbyqxmd.com/read/28306215/primary-mediastinal-and-retroperitoneal-malignant-germ-cell-tumors-in-children-and-adolescents-results-of-the-tgm95-trial-a-study-of-the-french-society-of-pediatric-oncology-soci%C3%A3-t%C3%A3-fran%C3%A3-aise-des-cancers-de-l-enfant
#1
Hélène Sudour-Bonnange, Cécile Faure-Conter, Hélène Martelli, Frederic Hameury, Brice Fresneau, Daniel Orbach, Cécile Vérité
PURPOSE: To examine the clinical presentation, treatment and results in children and adolescents with primary mediastinal (PM) and retroperitoneal (RP) germ cell tumors (GCTs). METHODS: The TGM95 trial for malignant GCTs was conducted in France between 1995 and 2005 to evaluate a strategy adapted to prognostic factors with cisplatin-based chemotherapy and surgical management. We reviewed patients with TGCTs at PM and RP sites. RESULTS: Among 239 patients, there were 16 patients with PM and 5 with RP tumors, which represent 9% of all patients, highlighting the rarity of these extragonadal locations...
March 17, 2017: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/28222996/stereotactic-radiation-therapy-for-residual-chemorefractory-primary-mediastinal-non-seminomatous-germ-cell-tumor-after-surgical-thoracotomy
#2
Philippe Laflamme, Cédric Doucet, Christian Sirois, Neil Kopek, Marie Vanhuyse
No abstract text is available yet for this article.
January 7, 2017: Practical Radiation Oncology
https://www.readbyqxmd.com/read/28202048/chemotherapy-for-primary-mediastinal-yolk-sac-tumor-in-a-patient-undergoing-chronic-hemodialysis-a-case-report
#3
Haruki Hirakawa, Chiho Nakashima, Tomomi Nakamura, Masanori Masuda, Taro Funakoshi, Shunsaku Nakagawa, Takahiro Horimatsu, Kazuo Matsubara, Manabu Muto, Shinya Kimura, Naoko Sueoka-Aragane
BACKGROUND: The safety and efficacy of chemotherapy for patients undergoing concomitant hemodialysis have not been fully established and optimal doses of anti-cancer drugs and best timing of hemodialysis remains unclear. Although chemosensitive cancers, such as germ cell tumors, treated with chemotherapy should have sufficient dose intensity maintained to achieve the desired effect, many patients with cancer undergoing hemodialysis might be under-treated because the pharmacokinetics of anti-cancer drugs in such patients remains unknown...
February 16, 2017: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/28161346/hypertestosteronemia-and-infertility-from-a-mediastinal-extragonadal-germ-cell-tumor
#4
Georgios K Dimitriadis, Gregory Kaltsas, Tarek Ghobara, Bidisa Sinha, Eftychia E Drakou, Kishore Gopalakrishnan, Christos Kosmas, Stephen D Keay, Dimitris K Grammatopoulos, Harpal S Randeva
No abstract text is available yet for this article.
February 2, 2017: American Journal of Medicine
https://www.readbyqxmd.com/read/28147469/thymoma-and-synchronous-primary-mediastinal-seminomas-with-florid-follicular-lymphoid-hyperplasia-in-the-anterior-mediastinum-a-case-report-and-review-of-the-literature
#5
Hyang-Im Lee, In-Seok Jang, Kyung Nyeo Jeon, Gyung Hyuck Ko, Jong Sil Lee, Dong Chul Kim, Dae Hyun Song, Jeong-Hee Lee
Thymoma is the most common neoplasm of the anterior mediastinum and has malignant potential. Germ cell tumors (GCTs) found in the anterior mediastinum are usually benign, and malignant GCTs, such as seminomas, are rare. Histologically, mediastinal seminoma is indistinguishable from testicular seminoma except for site-associated morphological features such as lymphoid follicular hyperplasia. Therefore, excluding metastasis is very important. Recently, we treated a young adult patient with multiple thymic masses that occurred simultaneously...
March 2017: Journal of Pathology and Translational Medicine
https://www.readbyqxmd.com/read/28103116/acute-leukemia-and-concurrent-mediastinal-germ-cell-tumor-case-report-and-literature-review
#6
Luke Maese, K David Li, Xinjie Xu, Zeinab Afify, Christian N Paxton, Angelica Putnam
There is a known association of primary nonseminomatous mediastinal germ cell tumors (NSMGCT) and hematologic malignancy in younger males not linked to treatment. When combined these two rare entities convey a very poor prognosis. Here we report a 16-year-old male with an anterior mediastinal mass diagnosed as a malignant germ cell tumor based on elevation of serologic markers. He was found to have acute leukemia with megakaryocytic differentiation several days later. We focus our report on the pathologic findings, including a review of the literature, and a novel molecular analysis of the germ cell tumor...
January 19, 2017: Fetal and Pediatric Pathology
https://www.readbyqxmd.com/read/28003760/comparison-of-the-clinical-features-and-hematopoietic-stem-cell-transplantation-outcomes-of-mediastinal-malignant-germ-cell-tumors-with-nonmediastinal-extragonadal-placements
#7
Nesrin Ocal, Birol Yildiz, Nuri Karadurmus, Deniz Dogan, Sukru Ozaydin, Ramazan Ocal, Mustafa Ozturk, Fikret Arpaci, Hayati Bilgic
OBJECTIVE: Even though the primary mediastinal extragonadal germ cell tumors (EGCTs) are rare, they are noteworthy in the differential diagnosis of mediastinal masses. In this study, we aimed to identify the clinical features of mediastinal malignant GCTs and compare the results of hematopoietic stem cell transplantation between mediastinal and nonmediastinal malignant EGCTs. METHOD: Data of the patients with EGCT who were treated and underwent hematopoietic stem cell transplantation at our hospital between 1988 and 2015 were retrieved retrospectively...
2016: OncoTargets and Therapy
https://www.readbyqxmd.com/read/27993806/impact-of-primary-metastatic-bone-disease-in-germ-cell-tumors-results-of-an-international-global-germ-cell-tumor-collaborative-group-g3-registry-study
#8
C Oing, K Oechsle, A Necchi, Y Loriot, U De Giorgi, A Fléchon, G Daugaard, M Fedyanin, E Faré, C Bokemeyer
BACKGROUND: Bone metastases (BM) are rare in germ cell tumor (GCT) patients. Systematic data on risk factors, treatment and outcome are largely lacking. PATIENTS AND METHODS: A database created by an international consortium including 123 GCT patients with BM at primary diagnosis was retrospectively analyzed. Survival estimates were calculated by the method of Kaplan-Meier and compared by log-rank testing. Cox regression analysis was applied for risk factor analyses...
December 19, 2016: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/27870561/high-dose-chemotherapy-and-autologous-peripheral-blood-stem-cell-transplantation-for-relapsed-metastatic-germ-cell-tumors-the-indiana-university-experience
#9
Nabil Adra, Rafat Abonour, Sandra K Althouse, Costantine Albany, Nasser H Hanna, Lawrence H Einhorn
Purpose Patients with relapsed metastatic germ cell tumor (GCT) can be cured with second-line and even third-line regimens. We report survival outcomes of patients treated with high-dose chemotherapy (HDCT) and peripheral-blood stem-cell transplantation (PBSCT) at Indiana University between 2004 and 2014. Patients and Methods We conducted a retrospective analysis of 364 consecutive patients with GCT who progressed after cisplatin-based combination chemotherapy and were subsequently treated with HDCT and PBSCT...
November 21, 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/27855672/nut-midline-carcinoma-mimicking-a-germ-cell-tumor-a-case-report
#10
Yohei Harada, Takafumi Koyama, Kengo Takeuchi, Kazufusa Shoji, Kazuei Hoshi, Yu Oyama
BACKGROUND: NUT midline carcinoma (NMC) is a rare and highly aggressive malignancy. Although more information on NMC has been recently accumulating in the literature, most oncologists and pathologists remain unfamiliar with the clinical and pathologic features of this disease. The clinical features of NMC sometimes mimic those of other malignancies, and NMC can therefore be overlooked if the diagnosis is not suspected. We present the case of a young male with NMC arising in the mediastinum with elevated serum alpha-fetoprotein levels suggestive of an extragonadal nonseminomatous germ-cell tumor...
November 17, 2016: BMC Cancer
https://www.readbyqxmd.com/read/27855414/clinical-characteristics-and-treatment-outcomes-of-patients-with-primary-mediastinal-germ-cell-tumors-10-years-experience-at-a-single-institution-with-a-bleomycin-containing-regimen
#11
Arunee Dechaphunkul, Siwat Sakdejayont, Chirawadee Sathitruangsak, Patrapim Sunpaweravong
BACKGROUND: Cisplatin-based chemotherapy followed by surgical resection of the residual tumor remains the standard of care for patients with mediastinal germ cell tumors (MGCTs). To prevent pulmonary complications, a non-bleomycin-containing regimen is generally preferred. This study aims to review the clinical characteristics and outcomes of these patients. METHODS: A retrospective chart review was undertaken in patients treated for MGCTs between 2003 and 2013...
2016: Oncology Research and Treatment
https://www.readbyqxmd.com/read/27760975/-two-cases-of-germ-cell-tumors-with-hyperthyroidism-due-to-high-serum-hcglevels
#12
Ichiro Chihara, Satoshi Nitta, Tomokazu Kimura, Shuya Kandori, Takashi Kawahara, Natsui Waku, Takahiro Kojima, Akira Joraku, Jun Miyazaki, Hitoshi Iwasaki, Hiroaki Suzuki, Koji Kawai, Hiroyuki Nishiyama
We reported two cases of hyperthyroidism that developed during induction chemotherapy for advanced germ cell tumors with high serum human chorionic gonadotropin (hCG) levels. Case 1 : An 18-year-old man with mediastinal choriocarcinoma complained of tachycardia and tremor. His pretreatment serum hCG level was 1.37 million mIU/ml. The free thyroxine (fT4) level measured on day 2 of the first course of bleomycin, etoposide and cisplatin (BEP) was elevated to 7.8 ng/dl (<1.7 ng/dl), whereasthe thyroidstimulating hormone (TSH) level was undetectable...
September 2016: Hinyokika Kiyo. Acta Urologica Japonica
https://www.readbyqxmd.com/read/27732956/the-prognostic-value-of-dna-damage-level-in-peripheral-blood-lymphocytes-of-chemotherapy-na%C3%A3-ve-patients-with-germ-cell-cancer
#13
Zuzana Sestakova, Katarina Kalavska, Lenka Hurbanova, Dana Jurkovicova, Jan Gursky, Michal Chovanec, Daniela Svetlovska, Vera Miskovska, Jana Obertova, Patrik Palacka, Katarina Rejlekova, Zuzana Sycova-Mila, Silvia Cingelova, Stanislav Spanik, Jozef Mardiak, Miroslav Chovanec, Michal Mego
Germ cell tumors (GCTs) are extraordinarily sensitive to cisplatin (CDDP)-based chemotherapy. DNA damage represents one of the most important factors contributing to toxic effects of CDDP-based chemotherapy. This study was aimed to evaluate the prognostic value of DNA damage level in peripheral blood lymphocytes (PBLs) from chemo-naïve GCT patients. PBLs isolated from 59 chemotherapy-naïve GCT patients were included into this prospective study. DNA damage levels in PBLs were evaluated by the Comet assay and scored as percentage tail DNA by the Metafer-MetaCyte analyzing software...
November 15, 2016: Oncotarget
https://www.readbyqxmd.com/read/27704516/prognostic-factors-in-children-with-extracranial-malignant-germ-cell-tumors-a-monocentric-pediatric-tunisian-study
#14
Faten Fedhila, Samar Rhayem, Habiba Hafsi, Wiem Douira, Raoudha Doghri, Monia Khemiri, Karima Mrad, Ibtissem Bellagha, Bechir Zouari, Sihem Barsaoui
Background Extracranial Germ cell tumors (GCT) are a rare and a heterogeneous group of pediatric cancers but highly curable. Aim We aimed to review management, outcome and prognostic factors that influence overall survival (OS) in a pediatric Tunisian oncologic unit. Methods We retrospectively evaluated between January 1998 and December 2012, 33 patients affected by extracranial germ cell tumors and treated according to TGM95 protocol established by the SFOPin a pediatric Tunisian oncologic unit. Results Patients had a mean age of 57 months (ranges: 1 day-13 years)...
April 2016: La Tunisie Médicale
https://www.readbyqxmd.com/read/27692810/effect-of-bleomycin-administration-on-the-development-of-pulmonary-toxicity-in-patients-with-metastatic-germ-cell-tumors-receiving-first-line-chemotherapy-a-meta-analysis-of-randomized-studies
#15
Andrea Necchi, Rosalba Miceli, Karima Oualla, Guru Sonpavde, Patrizia Giannatempo, Daniele Raggi, Nicola Nicolai, Roberto Boffi, Alessandra Busia, Luigi Mariani, Roberto Salvioni
BACKGROUND: Limited information is available about the effect of bleomycin administration on the development of pulmonary toxicity in metastatic germ cell tumors (GCT). PATIENTS AND METHODS: A literature search was conducted to identify randomized trials of first-line chemotherapy for GCT. We conducted univariate and multivariate analyses using random effects models to evaluate the predictive role of bleomycin administration in the development of all Grade and Grade 3 to 4 (G3-4) pulmonary toxicity...
September 8, 2016: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/27666557/-one-case-about-primary-mediastinal-primary-mediastinal-tumor-%C3%A2-with-mediastinal-sarcoma-and-literature-review
#16
Jinchen Du, Qingxin Li, Dong Chao, Yulian Ban, Qunqun Li
Primary mediastinal seminoma is a kind of germ cell malignancy outside the gonads, and it's rarer with sarcoma component. This disease which has no special clinical manifestations and imaging characteristics is difficult to identify with other mediastinal tumors and mediastinal type lung cancer. This paper reported a case of primary mediastinal seminoma with mediastinal sarcoma. Through the analysis of the diagnosis and treatment process in this patient, we will make a comprehensive review of the disease.
September 20, 2016: Zhongguo Fei Ai za Zhi, Chinese Journal of Lung Cancer
https://www.readbyqxmd.com/read/27646943/genetic-determinants-of-cisplatin-resistance-in-patients-with-advanced-germ-cell-tumors
#17
Aditya Bagrodia, Byron H Lee, William Lee, Eugene K Cha, John P Sfakianos, Gopa Iyer, Eugene J Pietzak, Sizhi Paul Gao, Emily C Zabor, Irina Ostrovnaya, Samuel D Kaffenberger, Aijazuddin Syed, Maria E Arcila, Raju S Chaganti, Ritika Kundra, Jana Eng, Joseph Hreiki, Vladimir Vacic, Kanika Arora, Dayna M Oschwald, Michael F Berger, Dean F Bajorin, Manjit S Bains, Nikolaus Schultz, Victor E Reuter, Joel Sheinfeld, George J Bosl, Hikmat A Al-Ahmadie, David B Solit, Darren R Feldman
PURPOSE: Owing to its exquisite chemotherapy sensitivity, most patients with metastatic germ cell tumors (GCTs) are cured with cisplatin-based chemotherapy. However, up to 30% of patients with advanced GCT exhibit cisplatin resistance, which requires intensive salvage treatment, and have a 50% risk of cancer-related death. To identify a genetic basis for cisplatin resistance, we performed whole-exome and targeted sequencing of cisplatin-sensitive and cisplatin-resistant GCTs. METHODS: Men with GCT who received a cisplatin-containing chemotherapy regimen and had available tumor tissue were eligible to participate in this study...
September 19, 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/27643524/primary-mediastinal-yolk-sac-tumors-an-immunohistochemical-analysis-of-14-cases
#18
Annikka Weissferdt, Neda Kalhor, Jaime Rodriguez Canales, Junya Fujimoto, Ignacio I Wistuba, Cesar A Moran
Primary mediastinal germ cell tumors are uncommon tumors that can pose diagnostic difficulties due to their morphologic spectrum and unusual site. Immunohistochemistry plays an increasing role in the diagnosis of these tumors. Whereas the immunophenotype of testicular yolk sac tumors (YST) is rather well known, the opposite is true for primary mediastinal YST leading us to investigate the immunohistochemical features of 14 such neoplasms. Fourteen cases of primary mediastinal YST were reviewed and representative whole tissue sections were selected for immunohistochemical analysis using antibodies directed against CAM5...
September 16, 2016: Applied Immunohistochemistry & Molecular Morphology: AIMM
https://www.readbyqxmd.com/read/27595361/germ-cell-tumors-in-adolescents-and-young-adults
#19
Gabriele Calaminus, Jonathan Joffe
Germ cell tumors (GCTs) represent a group of biologically complex malignancies that affect patients at different sites within the body and at different ages. The varying nature of these tumors reflects their cell of origin which is the primordial germ cell, which normally gives rise to ovarian and testicular egg and sperm producing cells. These cells retain an ability to give rise to all types of human tissues, and this is illustrated by the different kinds of GCTs that occur. In adolescent and young adult (AYA) patients, GCTs predominantly present as testicular, ovarian or mediastinal primary GCTs, and represent some of the most complex therapeutic challenges within any AYA practice...
2016: Progress in Tumor Research
https://www.readbyqxmd.com/read/27594554/a-suggested-prognostic-reclassification-of-intermediate-and-poor-risk-nonseminomatous-germ-cell-tumors
#20
Andrea Necchi, Gregory R Pond, Nicola Nicolai, Patrizia Giannatempo, Daniele Raggi, Nabil Adra, Nasser H Hanna, Roberto Salvioni, Lawrence H Einhorn, Costantine Albany
BACKGROUND: The International Germ Cell Cancer Collaborative Group (IGCCCG) classification has been used since 1997 to allocate metastatic germ cell tumors (GCTs), but its applicability needs an update. We aimed to revisit the outcomes of intermediate and poor risk nonseminomatous GCTs (NSGCTs). PATIENTS AND METHODS: Individual patient-level data from the databases of 2 institutions were collected. Outcomes of consecutive patients who received first-line chemotherapy from 1990 to 2014 were used...
August 8, 2016: Clinical Genitourinary Cancer
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