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Ryan E Stafford, Rafeef Aljuraifani, François Hug, Paul W Hodges
OBJECTIVES: To investigate whether increases in stiffness can be detected in the anatomical region associated with the striated urethral sphincter during voluntary activation using shear wave elastography; to identify the location and area of the stiffness increase relative to the point of greatest dorsal displacement of the mid urethra (i.e. striated urethral sphincter); and to determine the relationship between muscle stiffness and contraction intensity. SUBJECTS AND METHODS: Ten healthy men participated...
October 18, 2016: BJU International
Yan Ma, Shuo Zhang, Jing Li, Jianyi Li, Ye Kang, Weidong Ren
OBJECTIVE: To compare the diagnostic performances of strain elastography (SE) and shear-wave elastography (SWE) for predicting response to neoadjuvant chemotherapy (NACT) in patients with breast cancer. METHODS: This prospective study recruited 71 eligible patients from June 2014 to May 2016. All patients provided written informed consent. Tumour stiffness was assessed by the SE strain ratio (R), SWE maximum elasticity (Emax) and SWE mean elasticity (Emean). Ultrasonic elastography (UE) assessments were performed at each NACT cycle (t1 - t6)...
October 17, 2016: European Radiology
Frank W DiPaola, Kurt R Schumacher, Caren S Goldberg, Joshua Friedland-Little, Aishwarya Parameswaran, Jonathan R Dillman
OBJECTIVES: Assess liver stiffness using ultrasound point shear wave elastography (US P-SWE) in children before and after the Fontan operation. METHODS: Eighteen children undergoing the Fontan operation were prospectively enrolled. Eight US P-SWE measurements were obtained from the right hepatic lobe before surgery, and at multiple postoperative time points. Temporally related inferior vena cava pressure (IVC) data was collected from medical records, when available...
October 17, 2016: European Radiology
Ryan J Gallacher, Derek Keir, Nicholas Harmon, Graham Stuart, Sylvie Leroy, James O S Hammond, J-Michael Kendall, Atalay Ayele, Berhe Goitom, Ghebrebrhan Ogubazghi, Abdulhakim Ahmed
Melting of the mantle during continental breakup leads to magmatic intrusion and volcanism, yet our understanding of the location and dominant mechanisms of melt generation in rifting environments is impeded by a paucity of direct observations of mantle melting. It is unclear when during the rifting process the segmented nature of magma supply typical of seafloor spreading initiates. Here, we use Rayleigh-wave tomography to construct a high-resolution absolute three-dimensional shear-wave velocity model of the upper 250 km beneath the Afar triple junction, imaging the mantle response during progressive continental breakup...
October 18, 2016: Nature Communications
Noriyoshi Tsujino, Yu Nishihara, Daisuke Yamazaki, Yusuke Seto, Yuji Higo, Eiichi Takahashi
Seismic shear wave anisotropy is observed in Earth's uppermost lower mantle around several subducted slabs. The anisotropy caused by the deformation-induced crystallographic preferred orientation (CPO) of bridgmanite (perovskite-structured (Mg,Fe)SiO3) is the most plausible explanation for these seismic observations. However, the rheological properties of bridgmanite are largely unknown. Uniaxial deformation experiments have been carried out to determine the deformation texture of bridgmanite, but the dominant slip system (the slip direction and plane) has not been determined...
October 17, 2016: Nature
Tao Wu, Ping Wang, Ting Zhang, Jian Zheng, Shuoyang Li, Jie Zeng, Masatoshi Kudo, Rongqin Zheng
BACKGROUND: Noninvasive assessment of liver fibrosis has important clinical significance. Different techniques including two-dimensional shear-wave elastography (2D SWE) and real-time tissue elastography (RTE) are reported to be useful for the noninvasive diagnosis of hepatic fibrosis. All these techniques are affected by many factors. How to choose a reasonable method needs further studies. PURPOSE: This study was conducted to comparatively assess the diagnostic performance of 2D SWE and RTE in patients with Chronic Hepatitis B (CHB) and influence of inflammation on the stiffness values obtained by both techniques, so as to objectively assess the reasonable choice between these 2 elastography techniques for noninvasive assessment of hepatic fibrosis in clinical practice...
2016: Digestive Diseases
Molly A B Blank, James F Antaki
In this systematic review and meta-analysis, we report measured elasticities of benign and malignant breast pathologies from shear wave elastography (SWE), quantitatively confirm the effect of the selected region of interest (ROI) on these measures and test the hypothesis that a metric of heterogeneity based on the mean and maximum elasticity can improve specificity of diagnosis. The elasticities of benign, malignant and specific pathologic states are reported from 22 publications encompassing 2989 patients, identified from a structured search of the literature from May to September 2015...
October 14, 2016: Ultrasound in Medicine & Biology
Sébastien Aubry, Jean-Philippe Nueffer, Mathieu Carrié
In highly anisotropic biological tissues such as muscle or tendons, calculating Young's modulus from the shear wave speed (csw) by using shear wave elastography (SWE) involves a complex transversally isotropic rheological model not yet used in common practice. To our knowledge, the effect of muscle anisotropy on csw of intra-muscular lesions has not yet been investigated. The objective of our study was to define the effect of an anisotropic medium on csw of intra-muscular gelatinous inclusions. We conducted a prospective monocentric, in vitro study in order to examine the quantitative and qualitative SWE behavior of a 9-mm gelatinous intra-muscular implant depending on the orientation of the probe relative to the muscle fibers...
October 11, 2016: Ultrasound in Medicine & Biology
Yan-Lin Liu, Guo-Yang Li, Ping He, Ze-Qi Mao, Yanping Cao
Determining the mechanical properties of brain tissues is essential in such cases as the surgery planning and surgical training using virtual reality based simulators, trauma research and the diagnosis of some diseases that alter the elastic properties of brain tissues. Here, we suggest a protocol to measure the temperature-dependent elastic properties of brain tissues in physiological saline using the shear wave elastography method. Experiments have been conducted on six porcine brains. Our results show that the shear moduli of brain tissues decrease approximately linearly with a slope of -0...
September 21, 2016: Journal of the Mechanical Behavior of Biomedical Materials
Mainak Mookherjee, David Mainprice, Ketan Maheshwari, Olle Heinonen, Dhenu Patel, Anant Hariharan
Albite (NaAlSi3O8) is an aluminosilicate mineral. Its crystal structure consists of 3-D framework of Al and Si tetrahedral units. We have used Density Functional Theory to investigate the high-pressure behavior of the crystal structure and how it affects the elasticity of albite. Our results indicate elastic softening between 6-8 GPa. This is observed in all the individual elastic stiffness components. Our analysis indicates that the softening is due to the response of the three-dimensional tetrahedral framework, in particular by the pressure dependent changes in the tetrahedral tilts...
October 13, 2016: Scientific Reports
Harald Kramer, Perry J Pickhardt, Mark A Kliewer, Diego Hernando, Guang-Hong Chen, James A Zagzebski, Scott B Reeder
OBJECTIVE: The purpose of this study was to prospectively evaluate the accuracy of proton-density fat-fraction, single- and dual-energy CT (SECT and DECT), gray-scale ultrasound (US), and US shear-wave elastography (US-SWE) in the quantification of hepatic steatosis with MR spectroscopy (MRS) as the reference standard. SUBJECTS AND METHODS: Fifty adults who did not have symptoms (23 men, 27 women; mean age, 57 ± 5 years; body mass index, 27 ± 5) underwent liver imaging with un-enhanced SECT, DECT, gray-scale US, US-SWE, proton-density fat-fraction MRI, and MRS for this prospective trial...
October 11, 2016: AJR. American Journal of Roentgenology
Aditya B Singaraju, Kyle Nguyen, Abhay Jain, Rahul V Haware, Lewis L Stevens
The tableting performance for p-aminobenzoic acid (PABA) and a series of its benzoate esters with increasing alkyl chain length (methyl-, ethyl- and n-butyl) was determined over a broad range of compaction pressures. The crystalline structure of methyl benzoate (Me-PABA) exhibits no slip systems and does not form viable compacts under any compaction pressure. The ethyl (Et-PABA) and n-butyl (Bu-PABA) esters each have a similar, corrugated-layer structure that displays a prominent slip plane and improves material plasticity at low compaction pressure...
October 10, 2016: Molecular Pharmaceutics
Xiao-Lei Wang, Lin Tao, Xian-Li Zhou, Hong Wei, Jia-Wei Sun
OBJECTIVES: Breast cancer is a heterogeneous disease consisting of distinct histopathological subtypes with different clinical outcomes. In this article, we identified the automated breast volume scanning (ABVS) and shear wave velocity (SWV) characteristics of different pathological types of breast carcinoma. METHODS: A retrospective review of both ABVS and SWV imaging of 118 consecutive breast masses was performed. The imaging features of both techniques were assessed with reference to histopathological results...
October 5, 2016: Breast: Official Journal of the European Society of Mastology
Zhi Li Wang, Ye Li, Wen Bo Wan, Nan Li, Jie Tang
The goal of this study was to analyze the diagnostic performance of shear wave elastography (SWE) in differentiation of benign and malignant non-mass-like (NML) breast lesions. Three hundred sixteen consecutive breast lesions in 305 patients who have been scheduled for ultrasound (US)-guided core needle biopsy or vacuum-assisted biopsy or surgical excision between January 2013 and August 2013 were initially included in this study. Finally, 63 patients with 67 lesions classified as NML lesions comprised our study population...
October 4, 2016: Ultrasound in Medicine & Biology
Thierry Poynard, Tam Pham, Hugo Perazzo, Mona Munteanu, Elena Luckina, Djamel Elaribi, Yen Ngo, Luminita Bonyhay, Noemie Seurat, Muriel Legroux, An Ngo, Olivier Deckmyn, Dominique Thabut, Vlad Ratziu, Olivier Lucidarme
BACKGROUND AND AIMS: Real-time shear wave elastography (2D-SWE) is a two-dimensional transient elastography and a competitor as a biomarker of liver fibrosis in comparison with the standard reference transient elastography by M probe (TE-M). The aims were to compare several criteria of applicability, and to assess inflammation and steatosis impact on elasticity values, two unmet needs. METHODS: We took FibroTest as the fibrosis reference and ActiTest and SteatoTest as quantitative estimates of inflammation and steatosis...
2016: PloS One
Atilla Suleyman Dikici, Ismail Mihmanli, Fahrettin Kilic, Ahmet Ozkok, Gokhan Kuyumcu, Pinar Sultan, Cesur Samanci, Mehmet Halit Yilmaz, Babak Rafiee, Nevbahar Tamcelik, Zehra Isik Hasiloglu, Fatih Kantarci
BACKGROUND: Primary open-angle glaucoma is a multifactorial serious disease characterized by progressive retinal ganglion cell death and loss of visual field. OBJECTIVES: The purposes of this study were to investigate shear wave elastography (SWE) use in the evaluation of the optic nerve (ON) and peripapillary structures, and to compare the findings between glaucomatous and control eyes. PATIENTS AND METHODS: A case-controlled study, including 21 patients with primary open-angle glaucoma and 21 age-matched control subjects, was carried out...
April 2016: Iranian Journal of Radiology: a Quarterly Journal Published By the Iranian Radiological Society
Yasser A Elhosary, Saleh M Saleh, Wafaa M Ezzat, Dirk-André Clevert
BACKGROUND: Acoustic radiation force impulse (ARFI) evaluates liver stiffness non-invasively and was invented recently. This technique can easily and accurately assess the degree of liver fibrosis in clinical practice. AIM: The aim of this study was to detect the diagnostic performance of ARFI elastography in the staging of fibrosis in some Egyptian patients with chronic HCV infection. PATIENTS AND METHODS: One hundred ninety patients with chronic HCV infection; 142 men and 48 women were enrolled in the study...
September 15, 2016: Open Access Macedonian Journal of Medical Sciences
Florian Dittmann, Heiko Tzschätzsch, Sebastian Hirsch, Eric Barnhill, Jürgen Braun, Ingolf Sack, Jing Guo
PURPOSE: To develop a compact magnetic resonance elastography (MRE) protocol for abdomen and to investigate the effect of water uptake on tissue stiffness in the liver, spleen, kidney, and pancreas. METHODS: Nine asymptomatic volunteers were investigated by MRE before and after 1 liter water uptake. Shear-wave excitation at four frequencies was transferred to the abdomen from anterior and posterior directions using pressurized air drivers. Tomographic representations of shear-wave speed were produced by analysis of multifrequency wave numbers in axial and coronal images acquired within four breath-holds or under free breathing, respectively...
October 3, 2016: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
Takamichi Kuwahara, Yoshiki Hirooka, Hiroki Kawashima, Eizaburo Ohno, Hiroyuki Sugimoto, Daijuro Hayashi, Tomomasa Morishima, Manabu Kawai, Hiroki Suhara, Tomoaki Takeyama, Takeshi Yamamura, Kohei Funasaka, Masanao Nakamura, Ryoji Miyahara, Osamu Watanabe, Masatoshi Ishigami, Yoshie Shimoyama, Shigeo Nakamura, Senju Hashimoto, Hidemi Goto
BACKGROUND & AIMS: There is no established non-invasive method for diagnosis of pancreatic fibrosis. Shear wave elastography (SW-EG) may be a candidate for this purpose. The aims of this study were to assess the reproducibility of SW-EG in the normal imaging pancreas (Phase 1) and to evaluate the diagnostic performance of SW-EG for pancreatic fibrosis classified histologically (Phase 2). METHODS: Phase 1: This included 127 cases that underwent SW-EG of the normal imaging pancreas...
September 23, 2016: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
Steffen Zopf, Lara Rösch, Peter C Konturek, Ruediger S Goertz, Markus F Neurath, Deike Strobel
BACKGROUND Non-invasive procedures such as acoustic radiation force impulse imaging (ARFI) shear-wave elastography are currently used for the assessment of liver fibrosis. In the course of chronic hepatitis C, significant liver fibrosis or cirrhosis develops in approximately 25% of patients, which is a negative predictor of antiviral treatment response. Cirrhosis can be prevented by successful virus elimination. In this prospective study, a pretreatment ARFI cutoff value of 1.5 m/s was evaluated in relation to sustained virological response to anti-HCV therapy...
2016: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
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