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https://www.readbyqxmd.com/read/28944914/gene-screening-facilitates-diagnosis-of-complicated-symptoms-a-case-report
#1
Hong Duan, Di Zhang, Jing Cheng, Yu Lu, Huijun Yuan
Gene mutation has an important role in disease pathogenesis; therefore, genetic screening is a useful tool for diagnosis. The present study screened pathogenic genes, ectodysplasin A (EDA) and lamin A/C (LMNA), in a patient with suspected syndromic hearing impairment and various other symptoms including tooth and skin abnormalities. Large‑scale sequencing of 438 deafness‑associated genes and whole‑genome sequencing was also performed. The present findings did not identify copy number variation and mutations in EDA; therefore, excluding the possibility of EDA‑initiated ectodermal dysplasia syndrome...
September 22, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28944889/beneficial-effects-of-extracts-from-lucilia%C3%A2-sericata-maggots-on-burn-wounds-in-rats
#2
Haixu Bian, Qiaoli Yang, Tao Ma, Wei Li, Jialin Duan, Guo Wei, Xiaoxiao Wu, Fei Mu, Rui Lin, Aidong Wen, Miaomiao Xi
Lucilia sericata maggots have beneficial properties; however, their protective effects on burn wounds have yet to be fully elucidated. In the present study, a deep second‑degree burn rat model was used to investigate the burn wound healing properties of aqueous extract of maggots (MAE). The anti‑inflammatory, antioxidative and antibacterial activities were examined. In addition, the protein expression levels of Akt, vascular endothelial growth factor A (VEGFA) and nuclear factor‑κB (NF‑κB) were detected by western blotting...
September 20, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28944864/halofuginone-attenuates-articular-cartilage-degeneration-by-inhibition-of-elevated-tgf%C3%A2-%C3%AE-1-signaling-in-articular-cartilage-in-a-rodent-osteoarthritis-model
#3
Wenbo Mu, Boyong Xu, Hairong Ma, Baochao Ji, Zhendong Zhang, Jiao Li, Abdusami Amat, Li Cao
Osteoarthritis (OA) is the most common degenerative condition of the weight‑bearing joints worldwide without effective medical therapy. In order to investigate whether administration of halofuginone (HF) may attenuate OA, the present study allocated 3‑month‑old male mice into Sham group, vehicle‑treated anterior cruciate ligament transection (ACLT) group and HF‑treated ACLT group. The present study determined that HF treatment reduced the expression of matrix metallopeptidase‑13 and collagen X in articular cartilage...
September 20, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28944446/response-of-the-freshwater-diatom-halamphora-veneta-k%C3%A3-tzing-levkov-to-copper-and-mercury-and-its-potential-for-bioassessment-of-heavy-metal-toxicity-in-aquatic-habitats
#4
Weijie Mu, Kun Jia, Yan Liu, Xuming Pan, Yawen Fan
This study investigates the effects of copper and mercury on growth rate, chlorophyll a content, superoxide dismutase (SOD) activity, SOD mRNA gene expression, and frustule morphology of the benthic freshwater diatom Halamphora veneta (Kützing) Levkov and the potential utility of each for toxicity assessment in aquatic habitats. Results showed the following: (1) Compared to mercury, exposure to copper resulted in greater growth inhibition of H. veneta even at low concentrations and after short durations of exposure; (2) high accumulation of chlorophyll a in H...
September 25, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28943229/a-parallel-comparison-of-antigen-candidates-for-development-of-an-optimized-serological-diagnosis-of-schistosomiasis-japonica-in-the-philippines
#5
Pengfei Cai, Kosala G Weerakoon, Yi Mu, David U Olveda, Xianyu Piao, Shuai Liu, Remigio M Olveda, Qijun Chen, Allen G Ross, Donald P McManus
Schistosoma japonicum is stubbornly persistent in China and the Philippines. Fast and accurate diagnostic tools are required to monitor effective control measures against schistosomiasis japonica. Promising antigen candidates for the serological diagnosis of schistosomiasis japonica have generally been identified from the Chinese strain of S. japonicum. However, the Chinese (SjC) and Philippine (SjP) strains of S. japonicum express a number of clear phenotypic differences, including aspects of host immune responses...
September 18, 2017: EBioMedicine
https://www.readbyqxmd.com/read/28943208/preparation-of-mixed-monoterpenes-edge-activated-pegylated-transfersomes-to-improve-the-in-vivo-transdermal-delivery-efficiency-of-sinomenine-hydrochloride
#6
Juan Wang, Yan Wei, Ya-Rong Fei, Li Fang, Hang-Sheng Zheng, Chao-Feng Mu, Fan-Zhu Li, Yong-Sheng Zhang
Surfactants generally have been used as edge activators of transfersomes. However, surfactants edge activated transfersomes frequently lead to cutaneous irritation, skin lipid loss and other side effects after dermal administration. In this study, mixed monoterpenes edge activated PEGylated transfersomes (MMPTs) were prepared by ethanol injection process with sinomenine hydrochloride as a model drug. The formulation of MMPTs was optimized by an orthogonal design. We investigated skin permeation/deposition characteristics and pharmacokinetics of sinomenine hydrochloride loaded in MMPTs by comparing with liposomes using in vitro skin tests and in vivo cutaneous microdialysis...
September 21, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28942709/childhood-thyroid-function-reference-ranges-and-determinants-a-literature-overview-and-a-prospective-cohort-study
#7
Ibrahim Onsesveren, Mirjana Barjaktarovic, Layal Chaker, Yolanda B de Rijke, Vincent Wv Jaddoe, Hanneke M van Santen, Theo J Visser, Robin Peeters, Tim Korevaar
BACKGROUND: Reported cut-offs for childhood TSH and FT4 reference ranges vary widely and the knowledge on the determinants of childhood thyroid function is sparse. We aimed to summarize the existing studies on thyroid function reference ranges in children. Furthermore, our objective was to investigate the determinants of childhood TSH and FT4 concentration in a population based-prospective cohort. METHODS: First, to identify studies on childhood thyroid reference ranges, we systematically searched The National Library of Medicine's PubMed, Embase, Ovid Medline, Web of Science and Google Scholar databases...
September 23, 2017: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/28942530/propionate-metabolism-and-diversity-of-relevant-functional-genes-by-in-silico-analysis-and-detection-in-subsurface-petroleum-reservoirs
#8
Tao Yang, Serge Maurice Mbadinga, Lei Zhou, Shi-Zhong Yang, Jing-Feng Liu, Ji-Dong Gu, Bo-Zhong Mu
Propionate is a common metabolic intermediate occurring in environmental samples including petroleum reservoirs. Available microbial genomes were obtained from the NCBI database and analyzed in silico by hmmscan to check three metabolic pathways of propionate production in petroleum reservoir systems. The succinate pathway was the dominant one while the other two (lactate and 1,2-propanediol pathways) contributed less to the formation of propionate according to the Hidden Markov Model calculation. The mmdA gene encoding methylmalonyl-CoA decarboxylase was used as a biomarker gene to detect the diversity of microbes involved in the propionate formation in Jiangsu oil reservoirs...
September 23, 2017: World Journal of Microbiology & Biotechnology
https://www.readbyqxmd.com/read/28942456/staphylococcus-aureus-induces-osteoclastogenesis-via-the-nf-%C3%AE%C2%BAb-signaling-pathway
#9
Li-Rong Ren, Zhi-Hua Wang, Hai Wang, Xiao-Qing He, Mu-Guo Song, Yong-Qing Xu
BACKGROUND Osteomyelitis is one of the refractory diseases encountered in orthopedics, while Staphylococcus aureus (S. aureus) is the most common causative organism in osteomyelitis. However, the precise mechanisms underlying the bone loss caused by S. aureus infection have not been well defined. Here, we investigated the effect of S. aureus on osteoclast differentiation and the probable molecular mechanism. MATERIAL AND METHODS RAW 264.7 cells were treated for 5 days with live S. aureus, inactivated S. aureus, and S...
September 24, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28942034/agxt2-rs37369-polymorphism-predicts-the-renal-function-in-patients-with-chronic-heart-failure
#10
Xiao-Lei Hu, Wen-Jing Zeng, Mu-Peng Li, Yong-Long Yang, Da-Bin Kuang, He Li, Yan-Jiao Zhang, Chun Jiang, Li-Ming Peng, Hong Qi, Ke Zhang, Xiao-Ping Chen
Patients with chronic heart failure (CHF) are often accompanied with varying degrees of renal diseases. The purpose of this study was to identify rs37369 polymorphism of AGXT2 specific to the renal function of CHF patients. A total of 1012 southern Chinese participants, including 487 CHF patients without renal diseases and 525 healthy volunteers, were recruited for this study. Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was used to determine the genotypes of AGXT2 rs37369 polymorphism...
September 20, 2017: Gene
https://www.readbyqxmd.com/read/28941638/applying-mssim-combined-chaos-game-representation-to-genome-sequences-analysis
#11
Hai Ming Ni, Da Wei Qi, Hongbo Mu
Converting DNA sequence to image by using chaos game representation (CGR) is an effective genome sequence pretreatment technology, which provides the basis for further analysis between the different genes. In this paper, we have constructed 10 mammal species, 48 hepatitis E virus (HEV), and 10 kinds of bacteria genetic CGR images, respectively, to calculate the mean structural similarity (MSSIM) coefficient between every two CGR images. From our analysis, the MSSIM coefficient of gene CGR images can accurately reflect the similarity degrees between different genomes...
September 20, 2017: Genomics
https://www.readbyqxmd.com/read/28940943/associations-between-epidermal-growth-factor-receptor-mutations-and-histological-subtypes-of-lung-adenocarcinoma-according-to-the-iaslc-ats-ers-classification-in-chinese-patients
#12
Tengteng Wang, Yi Zhang, Baodong Liu, Mu Hu, Naikang Zhou, Xiuyi Zhi
BACKGROUND: This retrospective study was conducted to investigate the relationship between epidermal growth factor receptor (EGFR) mutation and histological subtypes of lung adenocarcinoma according to the International Association for the Study of Lung Cancer/American Thoracic Society/European Respiratory Society (IASLC/ATS/ERS) classification in Chinese patients. METHODS: Three hundred and seventy six surgically resected lung adenocarcinomas from Chinese PLA General Hospital were included in the study...
September 20, 2017: Thoracic Cancer
https://www.readbyqxmd.com/read/28940334/uncovering-a-third-dissolved-phase-129-xe-resonance-in-the-human-lung-quantifying-spectroscopic-features-in-healthy-subjects-and-patients-with-idiopathic-pulmonary-fibrosis
#13
Scott H Robertson, Rohan S Virgincar, Elianna A Bier, Mu He, Geoffrey M Schrank, Rose Marie Smigla, Craig Rackley, H Page McAdams, Bastiaan Driehuys
PURPOSE: The purpose of this work was to accurately characterize the spectral properties of hyperpolarized (129) Xe in patients with idiopathic pulmonary fibrosis (IPF) compared to healthy volunteers. METHODS: Subjects underwent hyperpolarized (129) Xe breath-hold spectroscopy, during which 38 dissolved-phase free induction decays (FIDs) were acquired after reaching steady state (echo time/repetition time = 0.875/50 ms; bandwidth = 8.06 kHz; flip angle≈22 °)...
October 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/28940238/soil-bacterial-diversity-changes-in-different-broomcorn-millet-intercropping-systems
#14
Xiaoning Cao, Sichen Liu, Junjie Wang, Haigang Wang, Ling Chen, Xiang Tian, Lijun Zhang, Jianwu Chang, Lun Wang, Zhixin Mu, Zhijun Qiao
Plants growing in soil and the diverse microorganisms with which they are in direct contact have adapted to exploit their close association for mutual benefit. Various intercropping systems have been used to control plant disease and improve productivity in fields. Although high-throughput sequencing approaches have provided new insights into the soil bacterial community, current knowledge of intercropping of broomcorn millet with different leguminous plants is limited. In this study, characterization of different bacterial communities of monoculture and intercropping systems was achieved by deep sequencing...
September 21, 2017: Journal of Basic Microbiology
https://www.readbyqxmd.com/read/28939832/inherent-humic-substance-promotes-microbial-denitrification-of-landfill-leachate-via-shifting-bacterial-community-improving-enzyme-activity-and-up-regulating-gene
#15
Shanshan Dong, Mu Li, Yinguang Chen
Microbial denitrification is the main pathway for nitrogen removal of landfill leachate. Although humic substances (HSs) have been reported in landfill leachate, the effects of HS on denitrification process of activated sludge for leachate treatment are still unknown. In this study, we adopted SAHA as the model HS to study the effects of HS on the denitrification of landfill leachate. After long-term operation at 10 mg/L of Shanghai Aladdin Humic Acid (SAHA), the final nitrate concentration and nitrite accumulation were much lower than the control (5...
September 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28939760/nemo-ikk%C3%AE-are-essential-for-irf3-and-nf-%C3%AE%C2%BAb-activation-in-the-cgas-sting-pathway
#16
Run Fang, Chenguang Wang, Qifei Jiang, Mengze Lv, Pengfei Gao, Xiaoyu Yu, Ping Mu, Rui Zhang, Sheng Bi, Ji-Ming Feng, Zhengfan Jiang
Cytosolic dsDNA activates the cyclic GMP-AMP synthase (cGAS)-stimulator of IFN genes (STING) pathway to produce cytokines, including type I IFNs. The roles of many critical proteins, including NEMO, IKKβ, and TBK1, in this pathway are unclear because of the lack of an appropriate system to study. In this article, we report that lower FBS concentrations in culture medium conferred high sensitivities to dsDNA in otherwise unresponsive cells, whereas higher FBS levels abrogated this sensitivity. Based on this finding, we demonstrated genetically that NEMO was critically involved in the cGAS-STING pathway...
September 22, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/28939570/perceptions-of-parents-and-paediatricians-on-pain-induced-by-bone-marrow-aspiration-and-lumbar-puncture-among-children-with-acute-leukaemia-a-qualitative-study-in-china
#17
Yu Wang, Qiang Liu, Jia-Ning Yu, Hai-Xia Wang, Lu-Lu Gao, Ya-Liang Dai, Xin Jin, Feng Zuo, Juan Liu, Cai-Feng Bai, Guo-Xia Mu, Xiao-Min Chai, Yin-Juan Zhang, Yu-Xiang Li, Jian-Qiang Yu
OBJECTIVE: To obtain in-depth insight into the perceptions of parents and paediatricians in China regarding current procedural pain management on bone marrow aspirations and lumbar punctures in paediatric haemato-oncology department. DESIGN, SETTING AND PARTICIPANTS: This qualitative study was conducted in a 4500-bed university hospital in northwest China. To collect data, in-depth semistructured interviews were conducted with parents of children with acute leukaemia (n=12) and haemato-oncology paediatricians (n=11) using purposive sampling...
September 21, 2017: BMJ Open
https://www.readbyqxmd.com/read/28939528/functional-activities-of-interferon-gamma-in-large-yellow-croaker-larimichthys-crocea
#18
Sisi Yang, Qiuhua Li, Yinnan Mu, Jingqun Ao, Xinhua Chen
Interferon gamma (IFN-γ) is a T helper cell type 1 (Th1) cytokine that plays important roles in almost all phases of immune and inflammatory responses. Although IFN-γ gene in large yellow croaker Larimichthys crocea has been reported, little is known about its bioactivity. In this study, large yellow croaker IFN-γ (LycIFN-γ) gene was found to be constitutively expressed in all tissues tested, with the highest levels in blood and heart. Based on stimulation with polyinosinic-polycytidylic acid [poly (I:C)] or inactivated trivalent bacterial vaccine, LycIFN-γ mRNA was significantly increased in spleen and head kidney tissues...
September 19, 2017: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/28939014/novel-endomorphin-analogs-are-more-potent-and-longer-lasting-analgesics-in-neuropathic-postoperative-inflammatory-and-visceral-pain-relative-to-morphine
#19
Amy K Feehan, Jenny Morgenweck, Xing Zhang, Ariel Amgott-Kwan, James E Zadina
Activation of the mu-opioid receptor provides the gold standard for pain relief, but a majority of opioids used clinically have adverse effects that have contributed to an epidemic of overdose deaths. We recently characterized mu-opioid receptor selective endomorphin (EM) analogs that provide potent antinociception with reduction or absence of a number of side effects of traditionally prescribed opioids including abuse liability, respiratory depression, motor impairment, tolerance, and inflammation [91]. The current study explores the effectiveness of these EM analogs relative to morphine in four major pain models by both intrathecal and intravenous administration in male, Sprague-Dawley rats and male CD-1 mice...
September 19, 2017: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/28938746/women-s-career-priority-is-associated-with-attitudes-towards-family-planning-and-ethical-acceptance-of-reproductive-technologies
#20
Michael K Simoni, Lin Mu, Stephen C Collins
STUDY QUESTION: Do women who place high importance on career success have different perceptions of pregnancy planning, delayed reproduction, and the ethical acceptability of ART than women with less emphasis on their career? SUMMARY ANSWER: Career-focused women place more importance on pregnancy planning, have greater confidence in delayed childbearing, and are more ethically accepting of donor gamete ART than women who do not place as much importance on career success...
October 1, 2017: Human Reproduction
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