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https://www.readbyqxmd.com/read/29161447/dna-polymerase-beta-participates-in-dna-end-joining
#1
Sreerupa Ray, Gregory Breuer, Michelle DeVeaux, Daniel Zelterman, Ranjit Bindra, Joann B Sweasy
DNA double strand breaks (DSBs) are one of the most deleterious lesions and if left unrepaired, they lead to cell death, genomic instability and carcinogenesis. Cells combat DSBs by two pathways: homologous recombination (HR) and non-homologous end-joining (NHEJ), wherein the two DNA ends are re-joined. Recently a back-up NHEJ pathway has been reported and is referred to as alternative NHEJ (aNHEJ), which joins ends but results in deletions and insertions. NHEJ requires processing enzymes including nucleases and polymerases, although the roles of these enzymes are poorly understood...
November 17, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/29159422/fine-mapping-of-qtls-for-individual-and-total-isoflavone-content-in-soybean-glycine-max-l-using-a-high-density-genetic-map
#2
Zhandong Cai, Yanbo Cheng, Zhuwen Ma, Xinguo Liu, Qibin Ma, Qiuju Xia, Gengyun Zhang, Yinghui Mu, Hai Nian
Fifteen stable QTLs were identified using a high-density soybean genetic map across multiple environments. One major QTL, qIF5-1, contributing to total isoflavone content explained phenotypic variance 49.38, 43.27, 46.59, 45.15 and 52.50%, respectively. Soybeans (Glycine max L.) are a major source of dietary isoflavones. To identify novel quantitative trait loci (QTL) underlying isoflavone content, and to improve the accuracy of marker-assisted breeding in soybean, a valuable mapping population comprised of 196 F7:8-10 recombinant inbred lines (RILs, Huachun 2 × Wayao) was utilized to evaluate individual and total isoflavone content in plants grown in four different environments in Guangdong...
November 20, 2017: TAG. Theoretical and Applied Genetics. Theoretische und Angewandte Genetik
https://www.readbyqxmd.com/read/29159329/self-assembly-of-au-ag-core-shell-nanocuboids-into-staircase-superstructures-by-droplet-evaporation
#3
Xianzhong Yang, Jing Li, Yuxin Zhao, Jianhua Yang, Liyan Zhou, Zhigao Dai, Xiao Guo, Shanjun Mu, Quanzhen Liu, Chunming Jiang, Mengtao Sun, Jianfang Wang, Wenjie Liang
Plasmonic nanomaterials, along with their assemblies, provide numerous applications due to their profound optical properties. In this work, we report the self-assembly of Au@Ag core-shell nanocuboids (NCs) into staircase superstructures in both vertical and horizontal orientations through two-stage droplet evaporation. Each stair is composed of a uniform well-aligned monolayer of NCs. The gap distance between NCs can be greatly shrunk to boost the corresponding surface-enhanced Raman scattering (SERS) performance using an ethanol wash method...
November 21, 2017: Nanoscale
https://www.readbyqxmd.com/read/29158796/radiotherapy-alone-or-concurrent-chemoradiation-for-esophageal-squamous-cell-carcinoma-in-elderly-patients
#4
Lina Zhao, Yongchun Zhou, Haitao Pan, Yutian Yin, Guangjin Chai, Yunfeng Mu, Feng Xiao, Steven H Lin, Mei Shi
Purpose: The reported data of elderly ESCC are rather limited and there is a lack of information to guide treatment decisions for elderly patients with esophageal cancer. This study aims to identify the efficacy and factors for optimal treatment approaches for elderly esophageal squamous cell carcinoma (ESCC) treated with radiotherapy (RT) alone or concurrent chemoradiation (CCRT). Methods: This study included 184 I-III elderly ESCC patients aged ≥70 years treated by oral single agent CCRT (sCCRT) or double agents CCRT (dCCRT) or RT alone at a single institution in China...
2017: Journal of Cancer
https://www.readbyqxmd.com/read/29158565/convergent-evolution-of-plant-and-animal-embryo-defences-by-hyperstable-non-digestible-storage-proteins
#5
María Yanina Pasquevich, Marcos Sebastián Dreon, Jian-Wen Qiu, Huawei Mu, Horacio Heras
Plants have evolved sophisticated embryo defences by kinetically-stable non-digestible storage proteins that lower the nutritional value of seeds, a strategy that have not been reported in animals. To further understand antinutritive defences in animals, we analysed PmPV1, massively accumulated in the eggs of the gastropod Pomacea maculata, focusing on how its structure and structural stability features affected its capacity to withstand passage through predator guts. The native protein withstands >50 min boiling and resists the denaturing detergent sodium dodecyl sulphate (SDS), indicating an unusually high structural stability (i...
November 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29158505/dynamic-profile-of-differentiated-thyroid-cancer-in-male-and-female-patients-with-thyroidectomy-during-2000-2013-in-china-a-retrospective-study
#6
Hui-Xian Yan, Ping Pang, Fu-Lin Wang, Wen Tian, Yu-Kun Luo, Wei Huang, Guo-Qing Yang, Nan Jin, Li Zang, Jin Du, Jian-Ming Ba, Jing-Tao Dou, Yi-Ming Mu, Zhao-Hui Lyu
The study aimed to investigate the gender-related differences of disease onset, age distribution, blood type, clinical characteristics, and malignant behaviors of differentiated thyroid carcinoma (DTC) in Chinese patients. A total of 7385 consecutive thyroid cancer patients who underwent thyroidectomy were retrospectively reviewed. 4087 (55.3%) were diagnosed as benign and the other (3298, 44.7%) were as malignant. DTC accounted for 97.6% in the malignant tumor. More single nodules turned out to be DTC in male compared to multiple nodules (46...
November 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29158293/gfzf-a-glutathione-s-transferase-protein-implicated-in-cell-cycle-regulation-and-hybrid-inviability-is-a-transcriptional-co-activator
#7
Douglas G Baumann, Mu-Shui Dai, Hua Lu, David S Gilmour
The core promoter of protein-encoding genes plays a central role in regulating transcription. M1BP is a transcriptional activator that associates with a core promoter element known as Motif 1 that resides at thousand of genes in Drosophila. To gain insight into how M1BP functions, we identified an interacting protein called GFZF. GFZF had been previously identified in genetic screens for factors involved in maintenance of hybrid inviability, the G2-M DNA damage checkpoint, and RAS/MAPK signaling but its contribution to these processes was unknown...
November 20, 2017: Molecular and Cellular Biology
https://www.readbyqxmd.com/read/29158161/extension-of-the-transposable-bacterial-virus-family-two-genomic-organisations-among-phages-and-prophages-with-a-tn552-related-transposase
#8
Ariane Toussaint, Frédérique Van Gijsegem
Mu-like transposable phages and prophages have been isolated from, or predicted, in a wide range of bacterial phyla. However, related B3-like transposable phages, which differ in their genome organisation and the DDE transposase and transposition activator they code for have thus far been restricted to a very limited set of hosts. Through sequence similarity searches, we have now expanded the number of predicted B3-like prophages and uncovered a third genomic organisation. These new genomes, although only prophages, further illustrate the previously reported mosaicism existing in the proposed "Saltoviridae" family of Caudovirales, and further support the proposal to move morphology criteria (contractile vs...
November 17, 2017: Research in Microbiology
https://www.readbyqxmd.com/read/29157981/foxo1-inhibition-promotes-differentiation-of-human-embryonic-stem-cells-into-insulin-producing-cells
#9
Fei Yu, Rui Wei, Jin Yang, Junling Liu, Kun Yang, Haining Wang, Yiming Mu, Tianpei Hong
Insulin-producing cells (IPCs) derived from human embryonic stem cells (hESCs) hold great potential for cell transplantation therapy in diabetes. Tremendous progress has been made in inducing differentiation of hESCs into IPCs in vitro, of which definitive endoderm (DE) protocol mimicking foetal pancreatic development has been widely used. However, immaturity of the obtained IPCs limits their further applications in treating diabetes. Forkhead box O1 (FoxO1) is involved in the differentiation and functional maintenance of murine pancreatic β cells, but its role in human β cell differentiation is under elucidation...
November 17, 2017: Experimental Cell Research
https://www.readbyqxmd.com/read/29157813/anti-inflammatory-and-antiviral-activities-of-cynanversicoside-a-and-cynanversicoside-c-isolated-from-cynanchun-paniculatum-in-influenza-a-virus-infected-mice-pulmonary-microvascular-endothelial-cells
#10
Panying Wei, Tao Zhang, Hong Dong, Qiaohong Chen, Xiang Mu, Ge Hu
BACKGROUND: Outbreaks of the influenza A virus (IAV) often occur in various avian and mammalian species, including humans, causing serious respiratory injury worldwide. Therapeutic actions are limited to vaccines and a few antiviral drugs. Combination antiviral compounds and anti-inflammatory modulators to control the propagation of viruses would be more efficient therapeutic strategies for infectious diseases. PURPOSE: This study was designed to isolate anti-inflammatory and antiviral compounds from Cynanchun paniculatum and elucidate their potential molecular mechanisms...
December 1, 2017: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/29156533/serotonin-induces-peripheral-antinociception-via-the-opioidergic-system
#11
Danielle Aguiar Diniz, Júlia Alvarenga Petrocchi, Larissa Caldeira Navarro, Tâmara Cristina Souza, Marina Gomes Miranda E Castor, Igor Dimitri Gama Duarte, Thiago Roberto Lima Romero
PURPOSE: Studies conducted since 1969 have shown that the release of serotonin (5-HT) in the dorsal horn of the spinal cord contributes to opioid analgesia. In the present study, the participation of the opioidergic system in antinociceptive effect serotonin at the peripheral level was examined. METHODS: The paw pressure test was used with mice (Swiss, males from 35 g) which had increased pain sensitivity by intraplantar injection of PGE2 (2 μg). Serotonin (250 ng), administered locally to the right paw of animals, produces antinociception in this model...
November 15, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29155787/synthesis-of-core-shell-lanthanide-doped-upconversion-nanocrystals-for-cellular-applications
#12
Xiangzhao Ai, Linna Lyu, Jing Mu, Ming Hu, Zhimin Wang, Bengang Xing
Lanthanide-doped upconversion nanocrystals (UCNs) have attracted much attention in recent years based on their promising and controllable optical properties, which allow for the absorption of near-infrared (NIR) light and can subsequently convert it into multiplexed emissions that span over a broad range of regions from the UV to the visible to the NIR. This article presents detailed experimental procedures for high-temperature co-precipitation synthesis of core-shell UCNs that incorporate different lanthanide ions into nanocrystals for efficiently converting deep-tissue penetrable NIR excitation (808 nm) into a strong blue emission at 480 nm...
November 10, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29155517/expression-of-cd40-cd40l-in-colon-cancer-and-its-effect-on-proliferation-and-apoptosis-of-sw48-colon-cancer-cells
#13
Xueqin Pang, Lifeng Zhang, Jiaming Wu, Chen Ma, Chuanyong Mu, Guangbo Zhang, Weichang Chen
PURPOSE: To study was to study the expression of CD40/CD40L in colon cancer and investigate the effects of CD40/CD40L overexpression on the proliferation and apoptosis of SW48 colon cancer cell line. METHODS: Immunohistochemistry was used to detect the expression of CD40 protein in colon cancer tissue samples from 70 patients, and 10 adjacent normal tissue samples. A CD40L gene-containing plasmid was transfected into SW48 colon cancer cells using lipofectamine 2000...
July 2017: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://www.readbyqxmd.com/read/29155417/growth-of-rutile-tio2-nanorods-in-ti-and-cu-ion-sequentially-implanted-sio2-and-the-involved-mechanisms
#14
Xiaoyu Mu, Xiaoyu Liu, Xiaohu Wang, Hai Tao Dai, Changlong Liu
TiO2 in nanoscale exhibits unique physicochemical and optoelectronic properties and has attracted much more interest of the researchers. In this work, TiO2 nanostructures are synthesized in amorphous SiO2 slices by implanting Ti ions, or sequentially implanting Ti and Cu ions combined with annealing at high temperature. The morphology, structure, spatial distribution and optical properties of the formed nanostructures have been investigated in detail. Our results clearly show that the thermal growth of TiO2 nanostructures in SiO2 substrate is significantly enhanced by presence of post Cu ion implantation, which depends strongly on the applied Cu ion fluence, as well as the annealing atmosphere...
November 20, 2017: Nanotechnology
https://www.readbyqxmd.com/read/29155273/mu-opioid-peptide-mop-and-nociceptin-orphanin-fq-peptide-nop-receptor-activation-both-contribute-to-the-discriminative-stimulus-properties-of-cebranopadol-in-the-rat
#15
Thomas M Tzschentke, Kris Rutten
The novel potent analgesic cebranopadol is an agonist at nociceptin/orphanin FQ peptide (NOP) and classical opioid receptors, with the highest in-vitro activity at NOP and mu-opioid peptide (MOP) receptors, and somewhat lower activity at kappa-opioid peptide (KOP) and delta-opioid peptide (DOP) receptors. We addressed the question of which of these pharmacological activities contribute to the stimulus properties of cebranopadol using a rat drug discrimination procedure. First, cebranopadol was tested in generalization tests against a morphine cue, including receptor-specific antagonism...
November 16, 2017: Neuropharmacology
https://www.readbyqxmd.com/read/29155208/inflammatory-renin-angiotensin-system-disruption-attenuates-sensory-hyperinnervation-and-mechanical-hypersensitivity-in-a-rat-model-of-provoked-vestibulodynia
#16
Anuradha Chakrabarty, Zhaohui Liao, Ying Mu, Peter G Smith
Vestibulodynia is characterized by peri-vaginal mechanical hypersensitivity, hyperinnervation, and abundant inflammatory cells expressing renin-angiotensin system proteins. We developed a tractable rat model of vestibulodynia to further assess the contributions of the renin-angiotensin system. Complete Freund's adjuvant (CFA) injected into the posterior vestibule induced marked vestibular hypersensitivity throughout a 7-day test period. Numbers of axons immunoreactive for PGP9.5, calcitonin gene-related peptide, and GFRα2 were increased...
November 15, 2017: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/29155093/histone-acetylation-of-oligodendrocytes-protects-against-white-matter-injury-induced-by-inflammation-and-hypoxia-ischemia-through-activation-of-bdnf-trkb-signaling-pathway-in-neonatal-rats
#17
Jichong Huang, Li Zhang, Yi Qu, Yan Zhou, Jianghu Zhu, Yafei Li, Tingting Zhu, Fengyan Zhao, Jun Tang, Dezhi Mu
The major pathological damage in encephalopathy of prematurity is white matter injury (WMI). Perinatal hypoxic-ischemia (HI) and inflammation are two major risk factors in the development of WMI. To study the cellular and molecular mechanisms of WMI, we set up a WMI model using lipopolysaccharide-sensitized HI injury in 2-day postnatal rats. Immunofluorescence staining was used to measure the expression of acetylated histone H3 (AH3) in oligodendrocytes, the target cells of WMI; the oligodendrocyte protein markers, NG2, O4, MBP, PLP, and MAG, were detected at different developmental stages...
November 16, 2017: Brain Research
https://www.readbyqxmd.com/read/29154801/human-small-bowel-as-a-useful-tool-to-investigate-smooth-muscle-effects-of-potential-therapeutics-in-organophosphate-poisoning
#18
Katharina Marquart, Olga Prokopchuk, Franz Worek, Horst Thiermann, Marc E Martignoni, Timo Wille
Isolated organs proofed to be a robust tool to study effects of (potential) therapeutics in organophosphate poisoning. Small bowel samples have been successfully used to reveal smooth muscle relaxing effects. In the present study, the effects of obidoxime, TMB-4, HI-6 and MB 327 were investigated on human small bowel tissue and compared with rat data. Hereby, the substances were tested in at least seven different concentrations in the jejunum or ileum both pre-contracted with carbamoylcholine. Additionally, the cholinesterase activity of native tissue was determined...
November 14, 2017: Toxicology Letters
https://www.readbyqxmd.com/read/29154632/auditory-over-visual-advantage-of-sensorimotor-synchronization-in-6-to-7-year-old-children-but-not-in-12-to-15-year-old-children-and-adults
#19
Yan Mu, Yingyu Huang, Chao Ji, Li Gu, Xiang Wu
The superiority of the auditory over visual modality in sensorimotor synchronization-a fundamental ability to coordinate movements with external rhythms-has long been established, whereas recent metronome synchronization work showed that synchronization of a visual bouncing ball was not less stable than synchronization of auditory tones in adults. The present study examined synchronization to isochronous sequences composed of auditory tones, visual flashes, or a bouncing ball in 6- to 7-year-old children, 12- to 15-year-old children, and 19- to 29-year-old adults...
November 20, 2017: Journal of Experimental Psychology. Human Perception and Performance
https://www.readbyqxmd.com/read/29154445/long-term-cardiovascular-morbidity-and-mortality-in-patients-treated-for-differentiated-thyroid-cancer
#20
Nelli Pajamäki, Saara Metso, Tommi Hakala, Tapani Ebeling, Heini Huhtala, Essi Ryödi, Juhani Sand, Arja Jukkola-Vuorinen, Pirkko-Liisa Kellokumpu-Lehtinen, Pia Jaatinen
OBJECTIVE: Thyroid hormone suppression therapy has been widely used in the treatment of thyroid cancer, but concerns have been raised about the cardiovascular risks of this treatment. The objective of this study was to evaluate long-term cardiovascular morbidity and mortality in patients treated for differentiated thyroid cancer (DTC) and to assess the effect of TSH suppression and radioiodine (RAI) treatment on the cardiovascular outcome. DESIGN: Retrospective cohort study...
November 20, 2017: Clinical Endocrinology
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