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https://www.readbyqxmd.com/read/29793199/effects-of-acute-and-chronic-exposures-of-fluoxetine-on-the-chinese-fish-topmouth-gudgeon-pseudorasbora-parva
#1
Hongxing Chen, Xiangfeng Zeng, Lei Mu, Liping Hou, Bin Yang, Jianliang Zhao, Daniel Schlenk, Wu Dong, Lingtian Xie, Qianru Zhang
Fluoxetine is a selective serotonin reuptake inhibitor used as an antidepressant and has been frequently detected in aquatic environments. However, its effects in fish from Asia remain relatively less studied. In this study, the topmouth gudgeon Pseudorasbora parva was exposed to 0, 50, and 200 µg/L of fluoxetine for 4 h and 42 d. The effects of fluoxetine on biometrics were compared to biochemical endpoints indicative of stress in different fish tissues (brain, liver, gills and intestine) following exposures...
May 21, 2018: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/29793119/bioaugmentation-potential-of-a-newly-isolated-strain-sphingomonas-sp-njust37-for-the-treatment-of-wastewater-containing-highly-toxic-and-recalcitrant-tricyclazole
#2
Haobo Wu, Jinyou Shen, Xinbai Jiang, Xiaodong Liu, Xiuyun Sun, Jiansheng Li, Weiqing Han, Yang Mu, Lianjun Wang
In order to develop an effective bioaugmentation strategy for the removal of highly toxic and recalcitrant tricyclazole from wastewater, a tricyclazole degrading strain was firstly successfully isolated and identified as Sphingomonas sp. NJUST37. In batch reactors, 100 mg L-1 tricyclazole could be completely removed within 102 h, which was accompanied by significant biomass increase, TOC and COD removal, as well as toxicity reduction. Chromatography analysis and density functional theory simulation indicated that monooxygenation occurred firstly, followed by triazole ring cleavage, decyanation reaction, hydration reaction, deamination, dihydroxylation and final mineralization reaction...
May 19, 2018: Bioresource Technology
https://www.readbyqxmd.com/read/29792999/does-solid-fusion-eliminate-rod-fracture-after-pedicle-subtraction-osteotomy-in-ankylosing-spondylitis-related-thoracolumbar-kyphosis
#3
Shi-Zhou Zhao, Bang-Ping Qian, Mu Qiao, Jun Jiang, Yong Qiu
BACKGROUND CONTEXT: Rod fracture (RF) has a negative impact on the surgical outcome of ankylosing spondylitis (AS) patients following lumbar pedicle subtraction osteotomy (PSO). However, there is a paucity of published studies analyzing the risk factors for RF in PSO-treated AS patients with thoracolumbar kyphosis. PURPOSE: To investigate the risk factors for RF after PSO for thoracolumbar kyphosis secondary to AS. STUDY DESIGN/SETTING: Retrospective single-center study...
May 21, 2018: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/29791710/postoperative-pain-and-analgesia-is-there-a-genetic-basis-to-the-opioid-crisis
#4
Randa K Elmallah, Prem N Ramkumar, Anton Khlopas, Rathika R Ramkumar, Morad Chughtai, Nipun Sodhi, Assem A Sultan, Michael A Mont
BACKGROUND: Multiple factors have been implicated in determining why certain patients have increased postoperative pain, with the potential to develop chronic pain. The purpose of this study was to: 1) identify and describe genes that affect postoperative pain perception and control; 2) address modifiable risk factors that result in epigenetic altered responses to pain; and 3) characterize differences in pain sensitivity and thresholds between opioid-naïve and opioid-dependent patients...
June 1, 2018: Surgical Technology International
https://www.readbyqxmd.com/read/29791346/characterization-of-the-focusing-performance-of-axial-line-focused-spiral-zone-plates
#5
Chenglong Zheng, Shilei Su, Huaping Zang, Ziwen Ji, Yongzhi Tian, Shu Chen, Kaijun Mu, Lai Wei, Quanping Fan, Chuanke Wang, Xiaoli Zhu, Changqing Xie, Leifeng Cao, Erjun Liang
Axial line-focused spiral zone plates were developed for operation at optical wavelengths. The design, fabrication, and diffraction properties of the proposed element are presented. Numerical results showed that hollow beams could be generated, and that the element can be employed for a multi-wavelength operation. The hollow beam within the focal depth was demonstrated experimentally, using a charge-coupled device camera and sliding guide. The results were consistent with those obtained by the simulations. The proposed optical device exhibits significant potential for various applications including optical manipulation and lithography...
May 10, 2018: Applied Optics
https://www.readbyqxmd.com/read/29790731/electrochemical-properties-of-lini0-6co0-2mn0-2o2-cathode-material-modified-by-lithium-tungstate-under-high-voltage
#6
Jiale Fu, Daobin Mu, Borong Wu, Jiaying Bi, Hui Cui, Hao Yang, Hanfeng Wu, Feng Wu
An amount (5wt.%) of lithium tungstate (Li2WO4) as an additive significantly improves the cycle and rate performances of LiNi0.6Co0.2Mn0.2O2 electrode at the cut-off voltage of 4.6V. The 5wt.% Li2WO4-mixed LiNi0.6Co0.2Mn0.2O2 electrode delivers a reversible capacity of 199.2 mAhg-1 and keeps 73.1% capacity for 200 cycles at 1C. It retains 67.4% capacity after 200 cycles at 2C and delivers a discharge capacity of 167.3mAh g-1 at 10C, while those of the pristine electrode are only 44.7% and 87.5mAh g-1, respectively...
May 23, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29790282/flexible-tio2-sio2-c-film-anodes-for-lithium-ion-batteries
#7
Ying Jiang, Shi Chen, Daobin Mu, Zhikun Zhao, Chunli Li, Zepeng Ding, Chaoxiang Xie, Feng Wu
Flexible TiO2/SiO2/C films are prepared via an electrospinning approach and used as self-supporting electrodes for LIBs, which exhibits excellent high-rate capability with a capacity of 115.5 mA h g-1 at 8 A g-1 (9.8 C rate) and good storage performance. It also shows great long-term cycle of 700 cycles at 200 mA g-1 with a capacity of 380.1 mA h g-1 and a high capacity retention of 88.3%s. Thus, it has the potential as electrodes for flexible LIBs owing to its flexibility and excellent electrochemical performance...
May 22, 2018: ChemSusChem
https://www.readbyqxmd.com/read/29790272/observation-of-a-metastable-p-heterocyclic-radical-by-muonium-addition-to-a-1-3-diphosphacyclobutane-2-4-diyl
#8
Shigekazu Ito, Yasuhiro Ueta, Kota Koshino, Kenji M Kojima, Iain McKenzie, Koichi Mikami
A 1,3-diphosphacyclobutane-2,4-diyl contains a unique unsaturated cyclic unit, and the presence of radical-type centres have been expected as a source of functionalities. This study demonstrates that the P-heterocyclic singlet biradical captures muonium (Mu = [µ+e-]) of the light isotope of hydrogen radical to generate an observable P-heterocyclic paramagnetic species. Investigation of a powder sample of 2,4-bis(2,4,6-tri-t-butylphenyl)-1-t-butyl-3-benzyl-1,3-diphosphacyclobutane-2,4-diyl by muon avoided level-crossing resonance (µLCR) spectroscopy revealed that muonium adds to the cyclic P2C2 unit...
May 22, 2018: Angewandte Chemie
https://www.readbyqxmd.com/read/29790186/predicting-events-in-clinical-trials-using-two-time-to-event-outcomes
#9
Rongji Mu, Jin Xu
In clinical trials with time-to-event outcomes, it is of interest to predict when a prespecified number of events can be reached. Interim analysis is conducted to estimate the underlying survival function. When another correlated time-to-event endpoint is available, both outcome variables can be used to improve estimation efficiency. In this paper, we propose to use the convolution of two time-to-event variables to estimate the survival function of interest. Propositions and examples are provided based on exponential models that accommodate possible change points...
May 22, 2018: Biometrical Journal. Biometrische Zeitschrift
https://www.readbyqxmd.com/read/29787936/dynamic-remobilization-of-leaf-nitrogen-components-in-relation-to-photosynthetic-rate-during-grain-filling-in-maize
#10
Xiaohuan Mu, Qinwu Chen, Fanjun Chen, Lixing Yuan, Guohua Mi
Remobilization of leaf nitrogen (N) contributes greatly to grain N in maize, but leads to low photosynthetic rate (Pn ). Pn is determined by various N components involving in light harvest and CO2 reduction. However, it is less clear which N component is the major contributor for the reduction of photosynthesis in modern stay-green maize hybrids. In this study, we analyzed the relationship between remobilization of different N components and Pn during grain filling stage under low N (no N application) and high N (180 kg N ha-1 ) in a field experiment...
May 16, 2018: Plant Physiology and Biochemistry: PPB
https://www.readbyqxmd.com/read/29787679/dynamic-proteome-alteration-and-functional-modulation-of-human-saliva-induced-by-dietary-chemosensory-stimuli
#11
Matthias Bader, Andreas Dunkel, Mareike Wenning, Bernd Kohler, Guillaume Medard, Estela Del Castillo, Amin Gholami, Bernhard Kuster, Siegfried Scherer, Thomas Hofmann
Saliva flow measurements and SDS-PAGE separation of human whole saliva freshly collected after oral stimulation with citric acid (sour), aspartame (sweet), iso-α-acids (bitter), mono sodium L-glutamate (umami), NaCl (salty), 6-gingerol (pungent), hydroxy-α-sanshool (tingling), and hydroxy-β-sanshool (numbing), followed by tryptic digestion, nano-HPLC-MS/MS, and label-free protein quantitation demonstrated a stimulus- and time-dependent influence of the dietary chemosensates on salivation and the salivary proteome composition...
May 22, 2018: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29785899/ragd-regulates-amino-acid-mediated-casein-synthesis-and-cell-proliferation-via-mtor-signalling-in-cow-mammary-epithelial-cells
#12
Ying Mu, Dongmei Zheng, Cong Wang, Wei Yu, Xiaonan Zhang
This research paper addresses the hypothesis that RagD is a key signalling factor that regulates amino acid (AA) mediated-casein synthesis and cell proliferation in cow mammary epithelial cells (CMECs). The expression of RagD was analysed at different times during pregnancy and lactation in bovine mammary tissue from dairy cows. We showed that expression of RagD at lactation period was higher (P < 0·05) than that at pregnancy period. When CMECs were treated with methionine (Met) or lysine (Lys), expression of RagD, β-casein (CSN2), mTOR and p-mTOR, and cell proliferation were increased...
May 2018: Journal of Dairy Research
https://www.readbyqxmd.com/read/29785888/the-impact-of-oprm1-s-genetic-polymorphisms-on-methadone-maintenance-treatment-in-opioid-addicts-a-systematic-review
#13
Bilel Oueslati, Olfa Moula, Rim Ghachem
AIM: Methadone is a long-acting opioid receptor agonist. It is prescribed to patients with opioid-related use disorders. The OPRM1 gene encodes for methadone's main receptor. It appears that polymorphisms in OPRM1 may affect the efficacy of methadone maintenance treatment (MMT). OBJECTIVE: Our purpose was to identify all relevant published papers dealing with the impact ofOPRM1's SNPs  on MMT's efficacy and to summarize results in order to evaluate the relevance of conducting pretherapeutic genotyping in opioid addicts prior to the onset of MMT...
May 22, 2018: Pharmacogenomics
https://www.readbyqxmd.com/read/29785874/-because-the-baby-asks-for-it-a-mixed-methods-study-on-local-perceptions-toward-nutrition-during-pregnancy-among-marginalised-migrant-women-along-the-myanmar-thailand-border
#14
Ahmar H Hashmi, Moo Kho Paw, Suphak Nosten, Mu Chae Darakamon, Mary Ellen Gilder, Prakaykaew Charunwatthana, Verena I Carrara, Kremlin Wickramasinghe, Chaisiri Angkurawaranon, Emma Plugge, Rose McGready
BACKGROUND: Under- and over-nutrition during pregnancy are known risk factors for pregnancy complications and adverse pregnancy and infant outcomes. Understanding perceptions around nutrition in pregnancy can create culturally appropriate interventions for improved health outcomes. OBJECTIVE: A mixed-methods study was performed to explore local perceptions and practices of diet and physical activity in pregnancy in a marginalised population along the Myanmar-Thailand border...
2018: Global Health Action
https://www.readbyqxmd.com/read/29785554/interactions-between-kappa-and-mu-opioid-receptor-agonists-effects-of-the-ratio-of-drugs-in-mixtures
#15
Vanessa Minervini, Hannah Y Lu, Jahnavi Padarti, Daniela C Osteicoechea, Charles P France
RATIONALE: Pain is the leading reason for seeking health care, and mu opioid receptor agonists continue to be prescribed despite well-documented adverse effects. Kappa opioid receptor agonists have antinociceptive effects with little to no abuse liability and might be useful for treating pain in mixtures. Kappa:mu opioid mixtures might be useful if therapeutic effects of each drug can be selectively increased while reducing or avoiding the adverse effects that occur with larger doses of each drug alone...
May 22, 2018: Psychopharmacology
https://www.readbyqxmd.com/read/29785114/convenient-food-made-of-extruded-adzuki-bean-attenuates-inflammation-and-improves-glycemic-control-in-patients-with-type-2-diabetes-a-randomized-controlled-trial
#16
Yanping Liu, Qiyan Wang, Shanshan Li, Yanfen Yue, Yuling Ma, Guixing Ren
Objective: Extrusion is a widely used food processing technology. The aim of this study was to investigate the effects of extruded adzuki bean convenient food (EABCF) on glycemic and inflammation control in type 2 diabetes mellitus (T2DM) patients. Patients and methods: In a randomized controlled trial, 120 T2DM patients were randomly assigned to a control diet group (the low glycemic index [LGI] group, assigned the traditional diabetic low glycemic index diet) or an intervention group (the EABCF group, assigned daily consumption of EABCF)...
2018: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/29784970/association-of-blood-pressure-with-fasting-blood-glucose-levels-in-northeast-china-a-cross-sectional-study
#17
Yaogai Lv, Yan Yao, Junsen Ye, Xin Guo, Jing Dou, Li Shen, Anning Zhang, Zhiqiang Xue, Yaqin Yu, Lina Jin
Hypertension and diabetes mellitus (DM) have become major public health issues, and previous studies have shown that there is an association between hypertension and DM. However, there is a lack of detailed information about this association. This study aimed to explore how different blood pressure (BP) levels were associated with fasting blood glucose (FBG) levels. A cross-sectional survey with adults aged 18 to 79 years was conducted in Jilin Province, China in 2012. Lambda-mu-sigma (LMS) was used to preliminarily explore the associations of BP with FBG...
May 21, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29784944/value-of-urinary-kim-1-and-ngal-combined-with-serum-cys-c-for-predicting-acute-kidney-injury-secondary-to-decompensated-cirrhosis
#18
Lei Lei, Liang Ping Li, Zhen Zeng, Jing Xi Mu, Xue Yang, Chao Zhou, Zhi Lan Wang, Hu Zhang
Urinary kidney injury molecule-1 (KIM-1), neutrophil gelatinase-associated lipocalin (NGAL), and serum cystatin C (Cys C) are biomarkers of acute kidney injury (AKI). However, the efficacy of combining these indices to diagnose decompensated cirrhosis is unknown. This study involved 150 patients divided into AKI and non-AKI, and healthy individuals. Urinary KIM-1 and NGAL, serum Cys and creatine, and glomerular filtration rate (GFR) were compared based on Child-Pugh liver function class. Urinary KIM-1 and NGAL concentrations and serum Cys C levels were significantly higher in patients with AKI secondary to decompensated cirrhosis than in those with AKI not secondary to decompensated cirrhosis (p < 0...
May 21, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29783015/extracts-of-compound-muniziqi-granule-suppressed-uterus-contraction-and-ameliorated-oxytocin-inducedprimary-dysmenorrhea
#19
Yue Wei, Tingyun Ma, Hanxue Wang, Jianguo Xing, Yuwen Wang, Zhengyi Gu, Dandan Mu, Qiang Yin, Xuemei Cheng, Changhong Wang
ETHNOPHARMACOLOGICAL RELEVANCE: Compound Muniziqi granule (CMG) is usually used as a traditional Uighur medicine to treat acne, chloasma, skin inflammation, primary dysmenorrhea (PDM), and menopausal syndrome. However, there are no sufficient data to support the clinic uses of CMG in PDM. AIM OF THE STUDY: This work aims to examine the effect of CMG as a treatment for PDM and reveal its possible therapeutic mechanism. MATERIALS AND METHODS: In vivo and in vitro mouse PDM models were utilized in this study...
May 18, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29781240/predominant-nonproductive-substrate-binding-by-fungal-cellobiohydrolase-i-and-implications-for-activity-improvement
#20
Mikhail L Rabinovich, Maria S Melnik, Mikhail L Herner, Yakov V Voznyi, Lilia G Vasilchenko
Enzymatic conversion of the most abundant renewable source of organic compounds, cellulose to fermentable sugars is attractive for production of green fuels and chemicals. The major component of industrial enzyme systems, cellobiohydrolase I from Hypocrea jecorina (Trichoderma reesei) (HjCel7A) processively splits disaccharide units from the reducing ends of tightly packed cellulose chains. HjCel7A consists of a catalytic domain (CD) and a carbohydrate-binding module (CBM) separated by a linker peptide. A tunnel-shaped substrate-binding site in the CD includes 9 subsites for β-D-glucose units, 7 of which (-7 to -1) precede the catalytic center...
May 21, 2018: Biotechnology Journal
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