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https://www.readbyqxmd.com/read/28329732/performance-analysis-of-different-rice-based-cropping-systems-in-tropical-region-of-nepal
#1
Anil Pokhrel, Peeyush Soni
Energy inputs, environmental impacts and economic outputs are the main concerns in today's agricultural production systems. The current study investigated the energy, environmental and financial performances of different rice-based cropping systems (CSs). The CSs studied were: Rice-Wheat-Fallow (R-W-F), Rice-Wheat-Maize (R-W-M), Rice-Wheat-Mungbean (R-W-Mu), Rice-Lentil-Maize (R-L-M), Rice-Lentil-Mungbean (R-L-Mu), Rice-Garlic (R-G) and Rice-Onion (R-O). Primary data were collected from 210 randomly selected farms by using structured questionnaire...
March 19, 2017: Journal of Environmental Management
https://www.readbyqxmd.com/read/28329692/organization-of-functional-long-range-circuits-controlling-the-activity-of-serotonergic-neurons-in-the-dorsal-raphe-nucleus
#2
Li Zhou, Ming-Zhe Liu, Qing Li, Juan Deng, Di Mu, Yan-Gang Sun
Serotonergic neurons play key roles in various biological processes. However, circuit mechanisms underlying tight control of serotonergic neurons remain largely unknown. Here, we systematically investigated the organization of long-range synaptic inputs to serotonergic neurons and GABAergic neurons in the dorsal raphe nucleus (DRN) of mice with a combination of viral tracing, slice electrophysiological, and optogenetic techniques. We found that DRN serotonergic neurons and GABAergic neurons receive largely comparable synaptic inputs from six major upstream brain areas...
March 21, 2017: Cell Reports
https://www.readbyqxmd.com/read/28329550/a-case-of-perniosis
#3
Euphemia W Mu, Vitaly Terushkin, Shane A Meehan, Marie Leger, Alisa Femia
Perniosis is a localized, inflammatory reaction that ischaracterized by erythematous papules and nodulesthat often are located on the acral surfaces in youngwomen. The lesions of perniosis are thought to bedue to cold-induced vasoconstriction that leadsto hypoxemia and inflammation of the vessel wall.Histopathologic and laboratory studies are indicatedfor patients with suspected perniosis to distinguishbetween idiopathic perniosis and secondaryperniosis. Treatment includes adequate heating andclothing, proper food intake, nifedipine, ultravioletA1 phototherapy, topical glucocorticoids, andvasodilators...
December 15, 2016: Dermatology Online Journal
https://www.readbyqxmd.com/read/28329543/herpes-simplex-virus-in-erythrokeratoderma-variabilis
#4
Shields Callahan, Euphemia Mu, Randie H Kim, Shane A Meehan, Paul Possick
We report a 48 -year-old woman witherythrokeratoderma variabilis, which is a rarehereditary disorder of keratinization, who developednew, painful, blisters within her skin lesions. Thediagnosis of herpes simplex virus infection was madebased on the clinical history and histopathologicfeatures. She was successfully treated withprophylactic valacyclovir, and her herpetic outbreakshave halted. This case serves as a reminder thateven among the most rare skin disorders, commonsecondary complications may be easily overlooked...
December 15, 2016: Dermatology Online Journal
https://www.readbyqxmd.com/read/28329001/experimental-demonstration-of-the-possible-role-of-acanthamoeba-polyphaga-in-the-infection-and-disease-progression-in-buruli-ulcer-bu-using-icr-mice
#5
Bright K Azumah, Phyllis G Addo, Alfred Dodoo, Gordon Awandare, Lydia Mosi, Daniel A Boakye, Michael D Wilson
The transmission of Buruli ulcer (BU), caused by Mycobacterium ulcerans (MU), remains puzzling although a number of hypothesis including through bites of infected aquatic insects have been proposed. We report the results of experiments using ICR mice that give credence to our hypothesis that Acanthamoeba species may play a role in BU transmission. We cocultured MU N2 and MU 1615 which expresses red fluorescent protein (RFP) and Acanthamoeba polyphaga (AP), and confirmed infected AP by Ziehl-Neelsen (ZN) staining...
2017: PloS One
https://www.readbyqxmd.com/read/28328199/fentanyl-initiated-polymers-prepared-by-atrp-for-targeted-delivery
#6
Devora Cohen-Karni, Marina Kovaliov, Shaohua Li, Stephen Jaffee, Nestor D Tomycz, Saadyah Averick
The targeted delivery of polymers to neurons is a challenging yet important goal for polymer based drug delivery. We prepared a fentanyl based atom transfer radical polymerization (ATRP) initiator to target the Mu opioid receptor (MOR) for neuronal targeting. We incorporated our recently discovered rigid acrylate linking group into the initiator to retain a high degree of binding to the MOR and grafted random or block copolymers of poly(oligo(ethylene oxide) methacrylate)-block-(glycidyl methacrylate). Trifluoroethanol promoted amine ring opening of the glycidyl methacrylate was used for post-polymerization modification of the fentanyl initiated polymers to attach a near-infrared fluorescent dye (ADS790WS) or to build a targeted siRNA delivery system via modification with secondary amines...
March 22, 2017: Bioconjugate Chemistry
https://www.readbyqxmd.com/read/28327717/one-step-synthesis-electronic-structure-and-photocatalytic-activity-of-earth-abundant-visible-light-driven-feal2o4
#7
Hui-Ying Mu, Fa-Tang Li, Xing-Tao An, Rui-Hong Liu, Yi-Lei Li, Xin Qian, Yong-Qi Hu
The development of inexpensive visible-light-driven photocatalysts is an important prerequisite for realizing the industrial application of photocatalysis technology. In this paper, an earth-abundant FeAl2O4 photocatalyst is prepared via facile solution combustion synthesis. Density functional theory and the scanning Kelvin probe technique are employed to ascertain the positions of the energy bands and the Fermi level. Phenol is taken as a model pollutant to evaluate the photocatalytic activity of FeAl2O4. The scavenger experiment results, ˙OH-trapping fluorescence technique, and electron spin resonance measurements confirm that the superoxide anion radical is the main active species generated in the photocatalytic process, which also further corroborates the proposed electronic structure of FeAl2O4...
March 22, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28327651/inhibition-of-cathepsin-s-confers-sensitivity-to-methyl-protodioscin-in-oral-cancer-cells-via-activation-of-p38-mapk-jnk-signaling-pathways
#8
Ming-Ju Hsieh, Chiao-Wen Lin, Mu-Kuan Chen, Su-Yu Chien, Yu-Sheng Lo, Yi-Ching Chuang, Yi-Ting Hsi, Chia-Chieh Lin, Jui-Chieh Chen, Shun-Fa Yang
Oral cancer is one of the most common cancers in the world. Approximately 90% of oral cancers are subtyped to oral squamous cell carcinoma (OSCC). Despite advances in diagnostic techniques and improvement in treatment modalities, the prognosis remains poor. Therefore, an effective chemotherapy mechanism that enhances tumor sensitivity to chemotherapeutics is urgently needed. Methyl protodioscin (MP) is a furostanol bisglycoside with a wide range of beneficial effects, including anti-inflammatory and anti-cancer properties...
March 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28327409/mir-23a-5p-modulates-mycobacterial-survival-and-autophagy-during-mycobacterium-tuberculosis-infection-through-tlr2-myd88-nf-%C3%AE%C2%BAb-pathway-by-targeting-tlr2
#9
Xing Gu, Yan Gao, De-Guang Mu, En-Qing Fu
Autophagy plays a pivotal role in activating the antimicrobial host defense against Mycobacterium tuberculosis (M.tb.). The emerging roles of microRNAs (miRNAs) in regulating immune responses have attracted increasing attention in recent years. Appreciating the potential of host-directed therapies designed to control autophagy during mycobacterial infection, we focused on the influence of miR-23a-5p on the activation of macrophage autophagy during M.tb. infection in bone marrow-derived macrophages (BMDMs) and murine RAW264...
March 18, 2017: Experimental Cell Research
https://www.readbyqxmd.com/read/28327189/microrna-27a-contributes-to-the-malignant-behavior-of-gastric-cancer-cells-by-directly-targeting-ph-domain-and-leucine-rich-repeat-protein-phosphatase-2
#10
Lei Ding, Shanyong Zhang, Mu Xu, Renwen Zhang, Pengcheng Sui, Qing Yang
BACKGROUND: Accumulating evidence indicates that microRNA-27a (miR-27a) is involved in carcinogenesis and tumor progression. However, the exact function and molecular mechanism of miR-27a in gastric cancer remain unclear. METHODS: Quantitative real-time PCR (qRT-PCR) was used to quantify the expression of miR-27a and its target gene. The function of miR-27a in gastric cancer was investigated through in vitro and in vivo assays (MTT assay, colony formation assay, flow cytometry assay, wound healing assay, migration and invasion assay, immunohistochemistry (IHC), immunofluorescence (IF) and Western blot)...
March 21, 2017: Journal of Experimental & Clinical Cancer Research: CR
https://www.readbyqxmd.com/read/28326034/the-presence-of-previous-cerebral-microbleeds-has-a-negative-effect-on-hypertensive-intracerebral-hemorrhage-recovery
#11
Kang Yang, Yulan Feng, JinJin Mu, Ningzhen Fu, Shufen Chen, Yi Fu
Background and Purpose: Cerebral microbleeds are an intracerebral microangiopathy with bleeding tendency found in intracerebral hemorrhage patients. However, studies about cerebral microbleed effects on the prognosis of hypertensive intracerebral hemorrhage patients are rare. We performed a prospective study to discuss not only the risk factors of cerebral microbleed incidence in hypertensive intracerebral hemorrhage patients but also the relevance of cerebral microbleeds with silent brain infarction, hemorrhage and prognosis...
2017: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/28324705/more-pain-more-gain-blocking-the-opioid-system-boosts-adaptive-cognitive-control
#12
Henk van Steenbergen, Daniel H Weissman, Dan J Stein, Susan Malcolm-Smith, Jack van Honk
The ability to adaptively increase cognitive control in response to cognitive challenges is crucial for goal-directed behavior. Recent findings suggest that aversive arousal triggers adaptive increases of control, but the neurochemical mechanisms underlying these effects remain unclear. Given the known contributions of the opioid system to hedonic states, we investigated whether blocking this system increases adaptive control modulations. To do so, we conducted a double-blind, placebo-controlled psychopharmacological study (n=52 females) involving a Stroop-like task...
March 7, 2017: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/28324033/effect-of-moxonidine-on-the-aldosterone-renin-ratio-in-healthy-male-volunteers
#13
Ashraf H Ahmed, Richard D Gordon, Gregory Ward, Martin Wolley, Brett C McWhinney, Jacobus P Ungerer, Michael Stowasser
Background: The most popular screening test for primary aldosteronism (PA) is the plasma aldosterone/ renin ratio (ARR). Medications, dietary sodium, posture and time of day all affect renin and aldosterone levels, and can result in false negative or positive ARRs if not controlled. Most antihypertensive medications affect the ARR and can interfere with interpretation of results. To our knowledge, no study has been undertaken to evaluate the effects of moxonidine on the ARR. Methods: Normotensive, non-medicated male volunteers (n=20) underwent measurement (seated, midmorning) of plasma aldosterone (by HPLC-tandem mass spectrometry), direct renin concentration (DRC), renin activity (PRA), cortisol, electrolytes and creatinine and urinary aldosterone, cortisol, electrolytes and creatinine at baseline, and after one week of moxonidine at 0...
March 16, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28323013/electroencephalographic-sensorimotor-rhythms-are-modulated-in-the-acute-phase-following-focal-vibration-in-healthy-subjects
#14
Susanna Lopez, Fabiano Bini, Claudio Del Percio, Franco Marinozzi, Claudia Celletti, Antonio Suppa, Raffaele Ferri, Emanuela Staltari, Filippo Camerota, Claudio Babiloni
Few minutes of focal vibration (FV) on limb muscles can improve motor control in neurological (stroke, Parkinson) patients for unknown underlying neurophysiological mechanisms. Here we hypothesized that in healthy volunteers this FV would increase excitability in the primary sensorimotor cortex (S1-M1) during an isometric contraction of the stimulated muscle. The design included an initial control condition with no FV stimulation (Baseline) as well as three short experimental sessions of FV and a Sham (fake) session in a pseudo-random order...
March 17, 2017: Neuroscience
https://www.readbyqxmd.com/read/28322544/graphene-oxide-quantum-dots-as-novel-nanozymes-for-alcohol-intoxication
#15
Anqi Sun, Li Mu, Xiangang Hu
Alcohol overconsumption as a worldwide issue results in alcoholic liver disease (ALD), such as steatosis, alcoholic hepatitis and cirrhosis. The treatment of ALD has been widely investigated but remains challenging. In this work, the protective effects of graphene oxide quantum dots (GOQDs) as novel nanozymes against alcohol overconsumption are discovered, and the specific mechanisms underlying these effects are elucidated via omics analysis. GOQDs dramatically alleviate the reduction of cell viability induced by ethanol and can act as nanozymes to accelerate ethanol metabolism and avoid the accumulation of toxic intermediates in cells...
March 21, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28322289/poly-%C3%AE-glutamic-acid-chitosan-nanogel-greatly-enhances-the-efficacy-and-heterosubtypic-cross-reactivity-of-h1n1-pandemic-influenza-vaccine
#16
Jihyun Yang, Sang-Mu Shim, Thi Quyen Nguyen, Eun-Ha Kim, Kwang Kim, Yong Taik Lim, Moon-Hee Sung, Richard Webby, Haryoung Poo
In 2009, the global outbreak of an influenza pandemic emphasized the need for an effective vaccine adjuvant. In this study, we examined the efficacy of poly-γ-glutamic acid/chitosan (PC) nanogel as an adjuvant for the influenza vaccine. PC nanogel significantly enhanced antigen-specific cross-presentation and cytotoxic T lymphocyte (CTL) activity. Compared with alum, the protective efficacy of the pandemic H1N1 influenza (pH1N1) vaccine was substantially increased by PC nanogel, with increased hemagglutination-inhibition titers, CTL activity, and earlier virus clearance after homologous and heterosubtypic [A/Philippines/2/82 (H3N2)] virus challenges...
March 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28321445/planar-b38-and-b37-clusters-with-a-double-hexagonal-vacancy-molecular-motifs-for-borophenes
#17
Qiang Chen, Wen-Juan Tian, Lin-Yan Feng, Hai-Gang Lu, Yue-Wen Mu, Hua-Jin Zhai, Si-Dian Li, Lai-Sheng Wang
Boron clusters have been found to exhibit a variety of interesting electronic, structural, and bonding properties. Of particular interest are the recent discoveries of the 2D hexagonal B36(-/0) which led to the concept of borophenes and the 3D fullerene-like B40(-/0) which marked the onset of borospherene chemistry. Here, we present a joint photoelectron spectroscopic and first-principles study of B37(-) and B38(-), which are in the transition size range between the 2D borophene-type clusters and the 3D borospherenes...
March 21, 2017: Nanoscale
https://www.readbyqxmd.com/read/28321124/combined-inhibition-of-%C3%AE-catenin-and-bcr-abl-synergistically-targets-tyrosine-kinase-inhibitor-resistant-blast-crisis-chronic-myeloid-leukemia-blasts-and-progenitors-in-vitro-and-in-vivo
#18
H Zhou, P Y Mak, H Mu, D H Mak, Z Zeng, J Cortes, Q Liu, M Andreeff, B Z Carter
Tyrosine kinase inhibitor (TKI) resistance and progression to blast crisis (BC), both related to persistent β-catenin activation remain formidable challenges for chronic myeloid leukemia (CML). We observed overexpression of β-catenin in BC-CML stem/progenitor cells, particularly in GMP progenitors, and highest among a novel CD34(+)CD38(+)CD123(hi)Tim-3(hi) subset as determined by CyTOF analysis. Co-culture with mesenchymal stromal cells (MSCs) induced the expression of β-catenin and its target CD44 in CML cells...
March 21, 2017: Leukemia: Official Journal of the Leukemia Society of America, Leukemia Research Fund, U.K
https://www.readbyqxmd.com/read/28321031/role-of-ketotifen-on-metabolic-profiles-inflammation-and-oxidative-stress-in-diabetic-rats
#19
Zimiao Chen, Hongwei Sun, Jian Wang, Liansong Ni, Xuejiang Gu, Shengjie Ge, Qiong Chen, Liangshan Mu, Xingbo Cheng
We aim to explore effects of Ketotifen on metabolic profiles, inflammation and oxidative stress. Sprague Dawley (SD) male rats were randomly divided into normal control group (NC) and experimental groups, and experimental group rats were fed with high-sugar and fat diet for 6 weeks. Then, experimental group rats were divided into diabetes group (DM) and ketotifen treatment group (KT). KT group was given ketotifen via Intragastric for 8 weeks with the dosage of 0.09 mg/kg•d. Fasting plasma glucose (FPG) was measured using glucose oxidase-phenol amino phenazone method...
March 17, 2017: Endocrine Journal
https://www.readbyqxmd.com/read/28320584/growth-charts-for-brazilian-children-with-down-syndrome-birth-to-20-years-of-age
#20
Fabio Bertapelli, Stamatis Agiovlasitis, Maira Rossmann Machado, Raísa do Val Roso, Gil Guerra-Junior
BACKGROUND: The growth of youth with Down syndrome (DS) differs from that of youth without DS, and growth charts specific to DS have been developed. However, little is known about the growth of Brazilian youth with DS. The objective of this study was to construct growth charts for Brazilian youth with DS and compare the growth data with the Child Growth Standards of the World Health Organization (WHO) and charts for children with DS from other studies. METHODS: Mixed longitudinal and cross-sectional data were collected at University of Campinas, 48 specialized centers for people with intellectual disabilities, and two foundations for people with DS between 2012 and 2015...
March 17, 2017: Journal of Epidemiology
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