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https://www.readbyqxmd.com/read/28815728/effects-of-bifenthrin-exposure-on-the-estrogenic-and-dopaminergic-pathways-in-zebrafish-embryos-and-juveniles
#1
Luísa Becker Bertotto, Jaben Richards, Jay Gan, David Christopher Volz, Daniel Schlenk
Bifenthrin (BF) is a pyrethroid insecticide used in urban and agricultural applications. Previous studies have shown that environmentally relevant (ng/L) concentrations of BF increased plasma concentrations of 17β-estradiol (E2) and altered the expression of dopaminergic (DA) pathway components. DA neurons can indirectly regulate E2 biosynthesis, suggesting that BF may disrupt the hypothalamic-pituitary-gonadal (HPG) axis. Since embryos do not have a complete HPG axis, the hypothesis that BF impairs DA regulation was tested in embryonic and one-month old juvenile zebrafish (Danio rerio) with exposure to measured concentrations of 0...
August 16, 2017: Environmental Toxicology and Chemistry
https://www.readbyqxmd.com/read/28797691/antidepressant-like-activity-of-venlafaxine-and-clonidine-in-mice-exposed-to-single-prolonged-stress-a-model-of-post-traumatic-stress-disorder-pharmacodynamic-and-molecular-docking-studies
#2
Natalia Malikowska, Łukasz Fijałkowski, Alicja Nowaczyk, Piotr Popik, Kinga Sałat
BACKGROUND: Post-traumatic stress disorder (PTSD) is a growing issue worldwide characterized by stress and anxiety in response to re-experiencing traumatic events which strongly impair patient's quality of life and social functions. Available antidepressant and anxiolytic drugs are not efficacious in the majority of treated individuals. This necessitates a significant medical demand to develop novel therapeutic strategies for PTSD. EXPERIMENTAL APPROACH: Animal model of PTSD was induced using a mouse single prolonged stress protocol (mSPS)...
August 7, 2017: Brain Research
https://www.readbyqxmd.com/read/28797200/the-polymorphism-of-dopamine-receptor-d4-drd4-and-dopamine-transporter-dat-genes-in-the-men-with-antisocial-behavior-and-mixed-martial-arts-fighters
#3
Elena Cherepkova, Vladimir Maksimov, Alexandr Kushnarev, Igor Shakhmatov, Lyubomir I Aftanas
OBJECTIVES: VNTR polymorphisms of DRD4 and DAT genes were studied in the Russian and Chechen men convicted of crimes, and two control groups comprised of the MMA fighters and a sample of general population. A group of MMA fighters included only the subjects without history of antisocial behavior. METHODS: DNA was isolated by phenol-chloroform extraction from the blood. Genotyping VNTR polymorphisms of the DRD4 and DAT genes were performed by PCR on published methods...
August 11, 2017: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/28783519/antimanic-activity-of-minocycline-in-a-gbr12909-induced-model-of-mania-in-mice-possible-role-of-antioxidant-and-neurotrophic-mechanisms
#4
Ana Isabelle G de Queiroz, Adriano José Maia Chaves Filho, Tatiane da Silva Araújo, Camila Nayane Carvalho Lima, Michel de Jesus Souza Machado, André F Carvalho, Silvania Maria Mendes Vasconcelos, David Freitas de Lucena, João Quevedo, Danielle Macedo
BACKGROUND: Mania/hypomania is the cardinal feature of bipolar disorder. Recently, single administration of the dopamine transporter (DAT) inhibitor, GBR12909, was related to mania-like alterations. In the present study we aimed at testing behavioral and brain oxidant/neurotrophic alterations induced by the repeated administration of GBR12909 and its prevention/reversal by the mood stabilizing drugs, lithium (Li) and valproate (VAL) as well as by the neuroprotective drug, minocycline (Mino)...
August 1, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28782870/rapid-eye-movement-sleep-behaviour-disorder-and-striatal-dopamine-depletion-in-patients-with-parkinson-s-disease
#5
S J Chung, Y Lee, J J Lee, P H Lee, Y H Sohn
BACKGROUND AND PURPOSE: Rapid eye movement sleep behaviour disorder (RBD) is related to striatal dopamine depletion. This study was performed to confirm whether clinically probable RBD (cpRBD) in patients with Parkinson's disease (PD) is associated with a specific pattern of striatal dopamine depletion. METHODS: A prospective survey was conducted using the RBD Screening Questionnaire (RBDSQ) in 122 patients with PD who had undergone dopamine transporter (DAT) positron emission tomography scan...
August 7, 2017: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/28774856/modafinil-improves-attentional-performance-in-healthy-non-sleep-deprived-humans-at-doses-not-inducing-hyperarousal-across-species
#6
Zackary A Cope, Arpi Minassian, Dustin Kreitner, David A MacQueen, Morgane Milienne-Petiot, Mark A Geyer, William Perry, Jared W Young
The wake-promoting drug modafinil is frequently used off-label to improve cognition in psychiatric and academic populations alike. The domain-specific attentional benefits of modafinil have yet to be quantified objectively in healthy human volunteers using tasks validated for comparison across species. Further, given that modafinil is a low-affinity inhibitor for the dopamine and norepinephrine transporters (DAT/NET respectively) it is unclear if any effects are attributable to a non-specific increase in arousal, a feature of many catecholamine reuptake inhibitors (e...
August 1, 2017: Neuropharmacology
https://www.readbyqxmd.com/read/28774469/thalamic-neurometabolic-alterations-in-tremulous-parkinson-s-disease-a-preliminary-proton-mr-spectroscopy-study
#7
Gaetano Barbagallo, Gennarina Arabia, Maurizio Morelli, Rita Nisticò, Fabiana Novellino, Maria Salsone, Federico Rocca, Andrea Quattrone, Manuela Caracciolo, Umberto Sabatini, Andrea Cherubini, Aldo Quattrone
INTRODUCTION: The objective of this study was to investigate the thalamic biochemical changes in tremor-dominant Parkinson's disease (tPD) patients in comparison with essential tremor with resting tremor (rET) patients, by using proton MR spectroscopy ((1)H-MRS). METHODS: Fourteen tPD patients, 12 rET patients and 10 controls participated in this study. All patients underwent dopamine transporter single-photon emission computed tomography (DAT-SPECT) with (123)I-ioflupane, and a short-echo single-voxel (1)H-MRS on a 3T scanner...
July 28, 2017: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/28766921/the-dopamine-transporter-role-in-psychiatric-phenotypes
#8
REVIEW
Angélica Salatino-Oliveira, Luis A Rohde, Mara H Hutz
The dopamine transporter (DAT) is one of the most relevant and investigated neurotransmitter transporters. DAT is a plasma membrane protein which plays a homeostatic role, controlling both extracellular and intracellular concentrations of dopamine (DA). Since unbalanced DA levels are known to be involved in numerous mental disorders, a wealth of investigations has provided valuable insights concerning DAT role into normal brain functioning and pathological processes. Briefly, this extensive but non-systematic review discusses what is recently known about the role of SLC6A3 gene which encodes the dopamine transporter in psychiatric phenotypes...
August 2, 2017: American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics
https://www.readbyqxmd.com/read/28754312/exercise-in-an-animal-model-of-parkinson-s-disease-motor-recovery-but-not-restoration-of-the-nigrostriatal-pathway
#9
M J Churchill, L Pflibsen, M D Sconce, C Moore, K Kim, C K Meshul
Many clinical studies have reported on the benefits of exercise therapy in patients with Parkinson's disease (PD). Exercise cannot stop the progression of PD or facilitate the recovery of dopamine (DA) neurons in the substantia nigra pars compacta (SNpc) (Bega et al., 2014). To tease apart this paradox, we utilized a progressive MPTP (1-methyl-4-phenyl-1,2,3,6-tetra-hydropyridine) mouse model in which we initiated 4weeks of treadmill exercise after the completion of toxin administration (i.e., restoration)...
July 25, 2017: Neuroscience
https://www.readbyqxmd.com/read/28750831/potential-role-of-tyrosine-hydroxylase-in-the-loss-of-psychostimulant-effect-of-amphetamine-under-conditions-of-impaired-dopamine-transporter-activity
#10
Egle Janenaite, Valentina Vengeliene, Anton Bespalov, Berthold Behl
Amphetamine and methylphenidate are known to have stimulatory effect in healthy subjects but not in humans with attention deficit hyperactivity disorder and in rodents with impaired dopamine transporter (DAT) function. This phenomenon is called the paradoxical calming effect of psychostimulants. It has been previously demonstrated that psychostimulants may regulate the enzymatic activity of tyrosine hydroxylase (TH). Hence, the objective of the present study was to determine whether the lack of activity-stimulating effects of amphetamine in hyperactive rats is associated with changes in TH activity...
July 24, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28747279/portable-objective-assessment-of-upper-extremity-motor-function-in-parkinson-s-disease
#11
L M Chahine, L Uribe, P Hogarth, J McNames, A Siderowf, K Marek, D Jennings
INTRODUCTION: Objective, portable measures of motor function for out-of-office assessments are needed in Parkinson's Disease (PD). This study had 3 objectives. First, to examine change in objective motor measurements in PD (as assessed with the Objective PD Measurement (OPDM) system). Second, to correlate objective measures with clinical features and putative PD cerebrospinal fluid (CSF) and dopaminergic imaging biomarkers. Third, to assess participant compliance with and perceptions of serial in-home motor assessments...
July 19, 2017: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/28744152/pharmacodynamic-genetic-polymorphisms-affect-adverse-drug-reactions-of-haloperidol-in-patients-with-alcohol-use-disorder
#12
Mikhail Sergeevich Zastrozhin, Vadim Markovich Brodyansky, Valentin Yurievich Skryabin, Elena Anatolievna Grishina, Dmitry Vladimirovich Ivashchenko, Kristina Anatolievna Ryzhikova, Ludmila Mikhaylovna Savchenko, Alexander Olegovich Kibitov, Evgeny Alekseevich Bryun, Dmitry Alekseevich Sychev
BACKGROUND: Antipsychotic action of haloperidol is due to blockade of D2 receptors in the mesolimbic dopamine pathway, while the adverse drug reactions are associated with striatal D2 receptor blockade. Contradictory data concerning the effects of genetic polymorphisms of genes encoding these receptors and associated structures (catechol-O-methyltransferase [COMT], glycine transporter and gene encoding the density of D2 receptors on the neuronal membrane) are described. OBJECTIVE: The objectives of this study were to evaluate the correlation between DRD2, SLC6A3 (DAT) and COMT genetic polymorphisms and to investigate their effect on the development of adverse drug reactions in patients with alcohol-use disorder who received haloperidol...
2017: Pharmacogenomics and Personalized Medicine
https://www.readbyqxmd.com/read/28743636/valproate-increases-dopamine-transporter-expression-through-histone-acetylation-and-enhanced-promoter-binding-of-nurr1
#13
Ashley L Green, Le Zhan, Aseel Eid, Helmut Zarbl, Grace L Guo, Jason R Richardson
The dopamine transporter (DAT) is the key regulator of dopaminergic transmission and is a target of several xenobiotics, including pesticides and pharmacological agents. Previously, we identified a prominent role for histone deacetylases in the regulation of DAT expression. Here, we utilized a rat dopaminergic cell line (N27) to probe the responsiveness of DAT mRNA expression to inhibitors of histone acetylation. Inhibition of histone deacetylases (HDACs) by valproate, butyrate and Trichostatin A led to a 3-10-fold increase in DAT mRNA expression, a 50% increase in protein levels, which were accompanied by increased H3 acetylation levels...
July 22, 2017: Neuropharmacology
https://www.readbyqxmd.com/read/28743458/s-phenylpiracetam-a-selective-dat-inhibitor-reduces-body-weight-gain-without-influencing-locomotor-activity
#14
Liga Zvejniece, Baiba Svalbe, Edijs Vavers, Marina Makrecka-Kuka, Elina Makarova, Vilnis Liepins, Ivars Kalvinsh, Edgars Liepinsh, Maija Dambrova
S-phenylpiracetam is an optical isomer of phenotropil, which is a clinically used nootropic drug that improves physical condition and cognition. Recently, it was shown that S-phenylpiracetam is a selective dopamine transporter (DAT) inhibitor that does not influence norepinephrine (NE) or serotonin (5-HT) receptors. The aim of the present study was to study the effects of S-phenylpiracetam treatment on body weight gain, blood glucose and leptin levels, and locomotor activity. Western diet (WD)-fed mice and obese Zucker rats were treated daily with peroral administration of S-phenylpiracetam for 8 and 12weeks, respectively...
July 22, 2017: Pharmacology, Biochemistry, and Behavior
https://www.readbyqxmd.com/read/28734777/inhibitor-mechanisms-in-the-s1-binding-site-of-the-dopamine-transporter-defined-by-multi-site-molecular-tethering-of-photoactive-cocaine-analogs
#15
Danielle Krout, Akula Bala Pramod, Rejwi Acharya Dahal, Michael J Tomlinson, Babita Sharma, James D Foster, Mu-Fa Zou, Comfort Boatang, Amy Hauck Newman, John R Lever, Roxanne A Vaughan, L Keith Henry
Dopamine transporter (DAT) blockers like cocaine and many other abused and therapeutic drugs bind and stabilize an inactive form of the transporter inhibiting reuptake of extracellular dopamine (DA). The resulting increases in DA lead to the ability of these drugs to induce psychomotor alterations and addiction, but paradoxical findings in animal models indicate that not all DAT antagonists induce cocaine-like behavioral outcomes. How this occurs is not known, but one possibility is that uptake inhibitors may bind at multiple locations or in different poses to stabilize distinct conformational transporter states associated with differential neurochemical endpoints...
July 19, 2017: Biochemical Pharmacology
https://www.readbyqxmd.com/read/28734204/molecular-dynamics-of-conformation-specific-dopamine-transporter-inhibitor-complexes
#16
Bernandie Jean, Christopher K Surratt, Jeffry D Madura
The recreational psychostimulant cocaine inhibits dopamine reuptake from the synapse, resulting in excessive stimulation of postsynaptic dopamine receptors in brain areas associated with reward and addiction. Cocaine binds to and stabilizes the outward- (extracellular-) facing conformation of the dopamine transporter (DAT) protein, while the low abuse potential DAT inhibitor benztropine prefers the inward- (cytoplasmic-) facing conformation. A correlation has been previously postulated between psychostimulant abuse potential and preference for the outward-facing DAT conformation...
July 11, 2017: Journal of Molecular Graphics & Modelling
https://www.readbyqxmd.com/read/28734031/downregulation-of-dec1-contributes-to-the-neurotoxicity-induced-by-mpp-by-suppressing-pi3k-akt-gsk3%C3%AE-pathway
#17
Zhu Zhu, Yu-Wen Wang, Ding-Hao Ge, Ming Lu, Wei Liu, Jing Xiong, Gang Hu, Xiao-Ping Li, Jian Yang
AIM: Differentiated embryonic chondrocyte gene 1 (DEC1) is involved in the neuronal differentiation and development. The aim of this study is to investigate the role of DEC1 in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPP(+) )-induced PD model. METHODS: The location of DEC1 and tyrosine hydroxylase (TH)-positive neurons were detected by immunofluorescence. 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced mouse subacute model of PD was established to evaluate the change of DEC1 expression in midbrain...
July 21, 2017: CNS Neuroscience & Therapeutics
https://www.readbyqxmd.com/read/28727685/erbb4-signaling-in-dopaminergic-axonal-projections-increases-extracellular-dopamine-levels-and-regulates-spatial-working-memory-behaviors
#18
M Skirzewski, I Karavanova, A Shamir, L Erben, J Garcia-Olivares, J H Shin, D Vullhorst, V A Alvarez, S G Amara, A Buonanno
Genetic variants of Neuregulin 1 (NRG1) and its neuronal tyrosine kinase receptor ErbB4 are associated with risk for schizophrenia, a neurodevelopmental disorder characterized by excitatory/inhibitory imbalance and dopamine (DA) dysfunction. To date, most ErbB4 studies have focused on GABAergic interneurons in the hippocampus and neocortex, particularly fast-spiking parvalbumin-positive (PV+) basket cells. However, NRG has also been shown to modulate DA levels, suggesting a role for ErbB4 signaling in dopaminergic neuron function...
July 20, 2017: Molecular Psychiatry
https://www.readbyqxmd.com/read/28710426/targeting-of-dopamine-transporter-to-filopodia-requires-an-outward-facing-conformation-of-the-transporter
#19
Shiqi Ma, Mary H Cheng, Daryl A Guthrie, Amy H Newman, Ivet Bahar, Alexander Sorkin
Dopamine transporter (DAT) has been shown to accumulate in filopodia in neurons and non-neuronal cells. To examine the mechanisms of DAT filopodial targeting, we used quantitative live-cell fluorescence microscopy, and compared the effects of the DAT inhibitor cocaine and its fluorescent analog JHC1-64 on the plasma membrane distribution of wild-type DAT and two non-functional DAT mutants, R60A and W63A, that do not accumulate in filopodia. W63A did not bind JHC1-64, whereas R60A did, although less efficiently compared to the wild-type DAT...
July 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28706191/aldehyde-dehydrogenase-1-positive-nigrostriatal-dopaminergic-fibers-exhibit-distinct-projection-pattern-and-dopamine-release-dynamics-at-mouse-dorsal-striatum
#20
Carmelo Sgobio, Junbing Wu, Wang Zheng, Xi Chen, Jing Pan, Armando G Salinas, Margaret I Davis, David M Lovinger, Huaibin Cai
Aldehyde dehydrogenase 1 (ALDH1A1)-positive dopaminergic (DA) neurons at the ventral substantia nigra pars compacta (SNpc) preferentially degenerate in Parkinson's disease (PD). Their projection pattern and dopamine release properties, however, remains uncharacterized. Here we show that ALDH1A1-positive axons project predominantly to the rostral two-thirds of dorsal striatum. A portion of these axons converge on a small fraction of striosome compartments restricted to the dorsolateral striatum (DLS), where less dopamine release was measured compared to the adjacent matrix enriched with the ALDH1A1-negative axons...
July 13, 2017: Scientific Reports
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