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https://www.readbyqxmd.com/read/29774753/zn-2-loaded-cellulose-beads-stabilized-by-chitosan-and-prepared-via-freeze-drying-for-removing-human-testosterone-in-plasma
#1
Huibin Yu, Hongqin Ke, Tu Chen, Xing Li, Shenglong Tan, Lei Zhou, Shenqi Wang
Hemoperfusion using metal ion affinity adsorbent is a promising method to remove human testosterone in plasma. Due to the leakage of metal ion from the adsorbents, there is no metal ion affinity adsorbent for hemoperfusion. In this study, chitosan was used to coat the adsorbent for preventing the leakage of Zn2+ loaded. Meanwhile, freeze-drying method was used to enhance adsorption capacity of Zn2+ -loaded cellulose beads for testosterone. The results indicate that after the adsorbent was coated by 0.02% chitosan solution, the highest adsorption percentage reached 48%, during adsorption, the Zn2+ concentration in plasma did not increase; the adsorption capacity of the adsorbent can be significantly enhanced by freeze-drying...
May 18, 2018: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/29773553/intratumoral-androgen-levels-are-linked-to-tmprss2-erg-fusion-in-prostate-cancer
#2
Matias Knuuttila, Arfa Mehmood, Jenni Mäki-Jouppila, Henrik Ryberg, Pekka Taimen, Juha Knaapila, Otto Ettala, Peter J Bostrom, Claes Ohlsson, Mikko S Venäläinen, Asta Laiho, Laura L Elo, Petra Sipilä, Sari Makela, Matti Poutanen
Intratumoral androgen biosynthesis is one of the mechanisms involved in the progression of prostate cancer, and an important target for novel prostate cancer therapies. Using gas chromatography-tandem mass spectrometry and genome-wide RNA sequencing, we have analyzed androgen concentrations and androgen-regulated gene expression in cancerous and morphologically benign prostate tissue specimens and serum samples obtained from 48 primary prostate cancer patients. Intratumoral DHT concentrations were significantly higher in the cancerous tissues compared to benign prostate (p<0...
May 17, 2018: Endocrine-related Cancer
https://www.readbyqxmd.com/read/29770194/clinical-utility-of-hyperbaric-oxygen-therapy-in-genitourinary-medicine
#3
REVIEW
Jason Gandhi, Omar Seyam, Noel L Smith, Gunjan Joshi, Sohrab Vatsia, Sardar Ali Khan
Hyperbaric oxygen therapy (HBOT) is a medical technique which delivers oxygen at ambient pressures to increase the amount of dissolved oxygen in the blood and oxygen distribution to tissues. There are several beneficial properties of HBOT concomitant with elevated oxygen distribution in tissue including anti-inflammation, angiogenesis through vascular endothelial growth factor proliferation, augmented fibroblast activity through fibroblast growth factor proliferation, tissue and wound repair, enhancement of lymphocyte and macrophage activity, increased male testosterone secretion, and bactericidal activity...
January 2018: Medical Gas Research
https://www.readbyqxmd.com/read/29770113/aggression-in-women-behavior-brain-and-hormones
#4
REVIEW
Thomas F Denson, Siobhan M O'Dean, Khandis R Blake, Joanne R Beames
We review the literature on aggression in women with an emphasis on laboratory experimentation and hormonal and brain mechanisms. Women tend to engage in more indirect forms of aggression (e.g., spreading rumors) than other types of aggression. In laboratory studies, women are less aggressive than men, but provocation attenuates this difference. In the real world, women are just as likely to aggress against their romantic partner as men are, but men cause more serious physical and psychological harm. A very small minority of women are also sexually violent...
2018: Frontiers in Behavioral Neuroscience
https://www.readbyqxmd.com/read/29769663/endogenous-testosterone-and-exogenous-oxytocin-influence-the-response-to-baby-schema-in-the-female-brain
#5
Sarah K C Holtfrerich, Roland Pfister, Alexander T El Gammal, Eugen Bellon, Esther K Diekhof
Nurturing behavior may be critically influenced by the interplay of different hormones. The neuropeptide oxytocin is known to promote maternal behavior and its reduction has been associated with postpartum depression risk and child neglect. Contrariwise, the observed decrease in testosterone level during early parenthood may benefit caretaking behavior, whereas increased testosterone may reduce attention to infants. Here we used functional magnetic resonance imaging to investigate the interactive influence of testosterone and oxytocin on selective attention to and neural processing of the baby schema (BS)...
May 16, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29768980/enhanced-steroidogenic-and-altered-antioxidant-response-by-zno-nanoparticles-in-mouse-testis-leydig-cells
#6
Nisha Bara, Gautam Kaul
Zinc oxide nanoparticles (ZnO NPs) are important nanomaterials with myriad applications and in widespread use. The main aim of this study was to evaluate the direct effect of ZnO NPs on steroidogenesis by considering mouse testicular Leydig cells (TM3) as an in vitro model system. The uptake, intracellular behaviour, cytotoxicity and morphological changes induced by ZnO NPs (0-200 µg/ml) in a time-dependent manner in the TM3 were assessed. A significant ( p < 0.05) decrease in TM3 viability was observed at 2 µg/ml ZnO NP after a 1-h incubation time period...
January 1, 2018: Toxicology and Industrial Health
https://www.readbyqxmd.com/read/29756046/hormonal-treatment-of-transgender-women-with-oral-estradiol
#7
Matthew C Leinung, Paul J Feustel, Jalaja Joseph
Purpose: Maintaining cross-sex hormone levels in the normal physiologic range for the desired gender is the cornerstone of transgender hormonal therapy, but there are limited data on how to achieve this. We investigated the effectiveness of oral estradiol therapy in achieving this goal. Methods: We analyzed data on all transgender females seen in our clinic since 2008 treated with oral estradiol. We looked at the success of achieving serum levels of testosterone and 17-β estradiol in the normal range on various doses of estradiol (with and without antiandrogens spironolactone and finasteride)...
2018: Transgender Health
https://www.readbyqxmd.com/read/29752772/associations-between-circulating-sex-steroid-hormones-and-leukocyte-telomere-length-in-men-in-the-national-health-and-nutrition-examination-survey
#8
S B Coburn, B I Graubard, B Trabert, K A McGlynn, M B Cook
Preliminary evidence suggests that sex steroid hormones, such as danazol (a synthetic sex steroid hormone), may be involved in enhancing telomerase activity. Elucidating underlying mechanisms of telomerase activity may further therapeutic options for individuals with telomeropathies and potentially avert certain age-related conditions. Therefore, we conducted a cross-sectional study to investigate the relationship between circulating sex steroid hormones and SHBG with leukocyte telomere length among 499 males in NHANES (1999-2002 surveys)...
May 11, 2018: Andrology
https://www.readbyqxmd.com/read/29748247/reduced-levels-of-stromal-sex-hormone-binding-globulin-and-androgen-receptor-dysfunction-in-the-sperm-storage-region-of-the-rat-epididymis
#9
Fabiane de Santi, Flávia L Beltrame, Barry T Hinton, Paulo S Cerri, Estela Sasso-Cerri
The cauda epididymidis is the major sperm storage region whose androgenic supply, essential for the sperm viability, is provided by the vasculature and is dependent upon testosterone diffusion through the stromal tissue to reach the epithelial cells. We have focused our efforts on examining the regulation of this important epididymal region by evaluating the impact of the androgen disrupter cimetidine on the epithelial-stromal androgenic microenvironment. Male rats received 100 mg/kg cimetidine (CMTG) or saline (CG) for 50 days, serum testosterone levels were measured and the epididymal cauda region was processed for light and transmission electron microscopy...
June 2018: Reproduction: the Official Journal of the Society for the Study of Fertility
https://www.readbyqxmd.com/read/29740398/neurosteroids-in-adult-hippocampus-of-male-and-female-rodents-biosynthesis-and-actions-of-sex-steroids
#10
REVIEW
Yasushi Hojo, Suguru Kawato
The brain is not only the target of steroid hormones but also is able to locally synthesize steroids de novo . Evidence of the local production of steroids in the brain has been accumulating in various vertebrates, including teleost fish, amphibia, birds, rodents, non-human primates, and humans. In this review, we mainly focus on the local production of sex steroids in the hippocampal neurons of adult rodents (rats and mice), a center for learning and memory. From the data of the hippocampus of adult male rats, hippocampal principal neurons [pyramidal cells in CA1-CA3 and granule cells in dentate gyrus (DG)] have a complete system for biosynthesis of sex steroids...
2018: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29738886/comparison-of-proteomic-profiles-in-the-ovary-of-sterlet-sturgeon-acipenser-ruthenus-during-vitellogenic-stages
#11
Mohammad Youneszadeh-Fashalami, Amir Parviz Salati, Saeed Keyvanshokooh
One of the challenges of sturgeon aquaculture is that sturgeon takes an extended amount of time to reach sexual maturity. The pattern of the protein expression in relation to the late maturity of sturgeon can help to better understand changes in sexual maturity. 17β-estradiol (E2), testosterone (T) and vitellogenin (Vtg) levels were examined at all stages of sexual maturation in Sterlet sturgeon (Acipenser ruthenus). Two-dimensional gel electrophoresis and mass spectrometry analysis were used to show the pattern of the ovarian proteins...
May 2, 2018: Comparative Biochemistry and Physiology. Part D, Genomics & Proteomics
https://www.readbyqxmd.com/read/29734846/the-efficacy-and-safety-of-short-acting-testosterone-ointment-glowmin-for-late-onset-hypogonadism-in-accordance-with-testosterone-circadian-rhythm
#12
Toshiyasu Amano, Teruaki Iwamoto, Yoshikazu Sato, Tetsuya Imao, Carolyn Earle
INTRODUCTION: It is well known that there is a reduction of circadian rhythm in blood testosterone levels with aging. Our previous report revealed that 3 mg of short-acting testosterone ointment (Glowmin: GL) elevated serum testosterone levels to within the physiological range for 4-6 h. The aim of this study was to clarify the clinical efficacy and safety of GL used topically once every morning, to enhance the circadian rhythm of testosterone, for late-onset hypogonadism (LOH). METHODS: A total of 61 LOH patients received 3 mg of GL topically once a day in the morning on scrotal skin for 24 weeks...
May 8, 2018: Aging Male: the Official Journal of the International Society for the Study of the Aging Male
https://www.readbyqxmd.com/read/29715189/co-exposure-to-endocrine-disruptors-effect-of-bisphenol-a-and-soy-extract-on-glucose-homeostasis-and-related-metabolic-disorders-in-male-mice
#13
Masoud Veissi, Sima Jafarirad, Akram Ahangarpour, Seyede Marjan Mohaghegh, Amal Saki Malehi
OBJECTIVES: Bisphenol A (BPA) is a xenoestrogen, which is commonly used as a monomer of polycarbonate plastics food containers and epoxy resins. Little is known about the interaction effects between xeno- and phyto- estrogens on glucose homeostasis or other metabolic disorders. The aim of this study was to examine effects of individual or combined exposure to low doses of BPA and soy extract on glucose metabolism in mice with the goal to establish its potential mechanisms. METHODS: Fifty-four male mice were randomly divided into six groups...
April 1, 2018: Endocrine Regulations
https://www.readbyqxmd.com/read/29704537/testosterone-and-fsh-modulate-sertoli-cell-extracellular-secretion-proteomic-analysis
#14
Francesca Mancuso, Mario Calvitti, Domenico Milardi, Giuseppe Grande, Giulia Falabella, Iva Arato, Stefano Giovagnoli, Federica Vincenzoni, Francesca Mancini, Claudio Nastruzzi, Maria Bodo, Tiziano Baroni, Massimo Castagnola, Riccardo Marana, Alfredo Pontecorvi, Riccardo Calafiore, Giovanni Luca
Spermatogenesis is a highly complicated biological process that occurs in the epithelium of the seminiferous tubules. It is regulated by a complex network of endocrine and paracrine factors and by juxtacrine testicular cross-talk. Sertoli cells (SC) play a key role in spermatogenesis due to their production of trophic, differentiation and immune-modulating factors, but many of the molecular pathways of SC action remain controversial and unclear. Over the last two decades, research has focused on extracellular vesicles as an important mechanism of intercellular communication...
April 25, 2018: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/29698782/altered-cytokine-profile-under-control-of-the-serotonergic-system-determines-the-regulation-of-cyp2c11-and-cyp3a-isoforms
#15
Marta Kot, Martine Daujat-Chavanieu
The aim of this study is to assess a potential mechanism by which the serotonergic system can control the expression and activity of cytochrome (CYP) 2C11 and CYP3A isoforms during liver insufficiency. A rat model of diethylnitrosamine (DEN)-induced liver insufficiency was developed by administering 50 mg/kg of DEN twice a week for 7 weeks. Dysfunction of the serotonergic system was evoked by feeding the rats with a tryptophan-free diet for three weeks. Dysfunction of the serotonergic system during liver insufficiency decreased the level of proinflammatory cytokines (TGF-β and IL-1β) and increased the level of an anti-inflammatory cytokine (IL-4)...
April 23, 2018: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/29695991/sex-hormones-and-processing-of-facial-expressions-of-emotion-a-systematic-literature-review
#16
Flávia L Osório, Juliana M de Paula Cassis, João P Machado de Sousa, Omero Poli-Neto, Rocio Martín-Santos
Background: We systematically reviewed the literature to determine the influence of sex hormones on facial emotion processing (FEP) in healthy women at different phases of life. Methods: Searches were performed in PubMed, Web of Science, PsycINFO, LILACS , and SciELO . Twenty-seven articles were included in the review and allocated into five different categories according to their objectives and sample characteristics (menstrual cycle, oral contraceptives, pregnancy/postpartum, testosterone, and progesterone)...
2018: Frontiers in Psychology
https://www.readbyqxmd.com/read/29688872/neural-correlates-of-emotional-action-control-in-anger-prone-women-with-borderline-personality-disorder
#17
Katja Bertsch, Karin Roelofs, Paul Jonathan Roch, Bo Ma, Saskia Hensel, Sabine C Herpertz, Inge Volman
BACKGROUND: Difficulty in controlling emotional impulses is a crucial component of borderline personality disorder (BPD) that often leads to destructive, impulsive behaviours against others. In line with recent findings in aggressive individuals, deficits in prefrontal amygdala coupling during emotional action control may account for these symptoms. METHODS: To study the neurobiological correlates of altered emotional action control in individuals with BPD, we asked medication-free, anger-prone, female patients with BPD and age- and intelligence-matched healthy women to take part in an approach-avoidance task while lying in an MRI scanner...
May 2018: Journal of Psychiatry & Neuroscience: JPN
https://www.readbyqxmd.com/read/29683499/the-role-of-androgens-on-periodontal-repair-in-female-rats
#18
João Paulo Steffens, Luis Carlos Leal Santana, Jonleno Coutinho Paiva Pitombo, Daniel Olivio Ribeiro, Maria Carolina Costa Albaricci, Stephanie von Stein Cubas Warnavin, Alpdogan Kantarci, Luis Carlos Spolidorio
BACKGROUND: Testosterone replacement enhances cognitive function and musculoskeletal health in postmenopausal women. However, the biological role of testosterone on inflammation and bone metabolism in females is not well understood. Our objective was to measure the impact of androgens and their receptors on periodontal tissues during periodontal repair in female rats. METHODS: Seventy female Holtzman rats were divided into seven groups (n = 10/group): negative control; repair control; androgen receptor antagonist (flutamide, 50 mg/kg, every other day); estrogen receptor antagonist (fulvestrant, 1...
April 2018: Journal of Periodontology
https://www.readbyqxmd.com/read/29670053/testosterone-dependent-mir-26a-5p-and-let-7g-5p-act-as-signaling-mediators-to-regulate-sperm-apoptosis-via-targeting-pten-and-pmaip1
#19
Jideng Ma, Yu Fan, Jinwei Zhang, Siyuan Feng, Zihui Hu, Wanling Qiu, Keren Long, Long Jin, Qianzi Tang, Xun Wang, Qi Zhou, Yiren Gu, Weihang Xiao, Lingyan Liu, Xuewei Li, Mingzhou Li
Recent evidence suggests that testosterone deficiency can dramatically decrease the quality of sperm. MicroRNAs (miRNAs) are conserved mediators of post-transcriptional gene regulation in eukaryotes. However, the systemic regulation and function of miRNAs in sperm quality decline induced by testosterone deficiency has not been investigated. Here, we found that the sperm apoptosis was significantly enhanced and the sperm motility was dramatically decreased in hemicastrated pigs. We then used small RNA sequencing to detect miRNA profiles of sperm from pigs with prepubertal hemicastration (HC) and compared them with control libraries...
April 18, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29667777/induced-pluripotent-stem-cell-derived-conditional-medium-promotes-leydig-cell-anti-apoptosis-and-proliferation-via-autophagy-and-wnt-%C3%AE-catenin-pathway
#20
Xiaoling Guo, Yong Chen, Tingting Hong, Xianwu Chen, Yue Duan, Chao Li, Renshan Ge
Leydig cell transplantation is a better alternative in the treatment of androgen-deficient males. The main purpose of this study was to investigate the effects of induced pluripotent stem cell-derived conditioned medium (iPS-CM) on the anti-apoptosis, proliferation and function of immature Leydig cells (ILCs), and illuminate the underlying mechanisms. ILCs were exposed to 200 μmol/L hydrogen peroxide (H2 O2 ) for 24 hours with or without iPS-CM treatments. Cell apoptosis was detected by flow cytometric analysis...
April 18, 2018: Journal of Cellular and Molecular Medicine
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