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https://www.readbyqxmd.com/read/29158199/male-rat-exposure-to-low-dose-of-di-2-ethylhexyl-phthalate-during-pre-pubertal-pubertal-and-post-pubertal-periods-impact-on-sperm-count-gonad-histology-and-testosterone-secretion
#1
Malha Oudir, Henni Chader, Bachir Bouzid, Kheira Bendisari, Batoul Latreche, Sofiane Boudalia, Mokrane Iguer-Ouada
Di (2-ethylhexyl) phthalate (DEHP) is the most ubiquitous endocrine disruptor in the environment. The present study aimed to investigate the low dose effects of DEHP on the male reproductive system of rats exposed during the pre-pubertal, pubertal and post-pubertal periods. Male Wistar rats were daily gavaged by DEHP from postnatal day (PND) 21 to PND 120 with 0.5, 50 and 5000μg/kg BW/d. A decrease in sperm count of 41%, 24% and 46% was observed at 0.5, 50 and 5000μg/kg BW/d respectively. A decrease of Sertoli cells number was observed at 50 and 5000μg/kg BW/d (22% and 42%, respectively)...
November 17, 2017: Reproductive Toxicology
https://www.readbyqxmd.com/read/29155264/modulation-of-adrenal-steroidogenesis-by-testosterone-in-the-lizard-coleonyx-elegans
#2
Rocco V Carsia, Patrick J McIlroy, Henry B John-Alder
Our previous work with adrenocortical cells from several Sceloporus lizard species suggests that gonadal hormones influence the steroidogenic capacity and the sensitivity to ACTH. However, there are discrepancies in these cellular response parameters suggesting that the effects of gonadal hormones on adrenocortical function vary with species, sex, age, season, and environmental/experimental conditions. To gain further insight into these complex interactions, here we report studies on Coleonyx elegans, Eublepharidae (Yucatán Banded Gecko), which is only distantly related to Sceloporus lizards via a basal common ancestor and in captivity, reproduces throughout the year...
November 16, 2017: General and Comparative Endocrinology
https://www.readbyqxmd.com/read/29154428/muscle-wasting-and-sarcopenia-in-heart-failure-and-beyond-update-2017
#3
REVIEW
Jochen Springer, Joshua-I Springer, Stefan D Anker
Sarcopenia (loss of muscle mass and muscle function) is a strong predictor of frailty, disability and mortality in older persons and may also occur in obese subjects. The prevalence of sarcopenia is increased in patients suffering from chronic heart failure. However, there are currently few therapy options. The main intervention is resistance exercise, either alone or in combination with nutritional support, which seems to enhance the beneficial effects of training. Also, testosterone has been shown to increased muscle power and function; however, a possible limitation is the side effects of testosterone...
November 2017: ESC Heart Failure
https://www.readbyqxmd.com/read/29150303/oxytocin-intranasal-administration-as-a-new-hope-for-hypogonadotropic-hypogonadism-patients
#4
Mohammad Saied Salehi, Sareh Pandamooz, Homayoun Khazali
Hypogonadotropic hypogonadism (HH) is a form of hypogonadism which also known as secondary or central hypogonadism. Congenital HH can occur due to defect in gonadotropin releasing hormone (GnRH) neurons, upstream regulators of GnRH neurons or pituitary gonadotropic cells. Testosterone or gonadotropins therapy are widely used to treat HH patients, however both have undesirable effects and GnRH treatment for HH patients is time and cost consuming. Direct delivery of therapeutics to the brain via the nasal route is located in the center of attention during the last decade and trial application of intranasal oxytocin as a method of enhancing social interactions are reported...
November 2017: Medical Hypotheses
https://www.readbyqxmd.com/read/29148981/walnut-leaf-extract-acts-as-a-fertility-agent-in-male-wistar-albino-rats-a-search-for-herbal-male-fertility-enhancer
#5
Seun F Akomolafe, Ganiyu Oboh
Background Walnut leaf is one of the many medicinal plants used in folklore as male fertility enhancers. The present work was therefore undertaken with an aim to scientifically validate this claim. As such, we evaluated the effect of the aqueous extract from walnut leaves on biomolecules related to fertility in adult male rats and its mode of action as fertility-enhancing agent. Methods Twenty-five rats were randomly divided into five groups of five animals each; Group 1 served as control and received normal (0...
November 17, 2017: Journal of Complementary & Integrative Medicine
https://www.readbyqxmd.com/read/29146110/exploring-molecular-mechanism-of-bone-forming-capacity-of-eurycoma-longifolia-evidence-of-enhanced-expression-of-bone-related-biomarkers
#6
Hnin Ei Thu, Isa Naina Mohamed, Zahid Hussain, Ahmad Nazrun Shuid
BACKGROUND: Among the numerous well-documented medicinal herbs, Eurycoma longifolia (EL) has gained remarkable recognition due to its promising efficacy of stimulating bone formation in androgen-deficient osteoporosis. Though numerous animal studies have explored the bone-forming capacity of EL, the exact mechanism was yet to be explored. OBJECTIVES: The present study was aimed to investigate the mechanism of bone-forming capacity of EL using MC3T3-E1 as an in vitro osteoblastic model...
November 13, 2017: Journal of Ayurveda and Integrative Medicine
https://www.readbyqxmd.com/read/29143629/from-erasure-to-opportunity-a-qualitative-study-of-the-experiences-of-transgender-men-around-pregnancy-and-recommendations-for-providers
#7
Alexis Hoffkling, Juno Obedin-Maliver, Jae Sevelius
BACKGROUND: Some transgender men retain their uterus, get pregnant, and give birth. However, societal attitudes about gender have erected barriers to openly being pregnant and giving birth as a transgender man. Little research exists regarding transgender men's reproductive needs. Anecdotal observations suggest that social change and increasing empowerment of transgender men may result in increasing frequency and openness about pregnancy and birth. Specific needs around conception, pregnancy, and newborn care may arise from transphobia, exogenous testosterone exposure, or from having had (or desiring) gender-affirming surgery...
November 8, 2017: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/29138225/androgen-signaling-expands-%C3%AE-cell-mass-in-male-rats-and-%C3%AE-cell-androgen-receptor-is-degraded-under-high-glucose-conditions
#8
Naoki Harada, Yasuhiro Yoda, Yusuke Yotsumoto, Tatsuya Masuda, Yuji Takahashi, Takahiro Katsuki, Kenji Kai, Nobuaki Shiraki, Hiroshi Inui, Ryoichi Yamaji
A deficient pancreatic β-cell mass increases the risk of type 2 diabetes mellitus. Here, we investigated the effects of testosterone on the development of pancreatic β-cell mass in male rats. The β-cell mass of male rats castrated at 6 weeks of age was reduced to ~30% of that of control rats at 16 weeks of age, and castration caused glucose intolerance. Loss of β-cell mass occurred due to decreases in islet density/pancreas and β-cell cluster size. Castration was negatively associated with the number of Ki67-positive β-cells and positively associated with the number of TUNEL-positive β-cells...
November 14, 2017: American Journal of Physiology. Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29125859/insulin-resistance-enhances-the-mitogen-activated-protein-kinase-signaling-pathway-in-ovarian-granulosa-cells
#9
Linghui Kong, Qien Wang, Jiewen Jin, Zou Xiang, Taoyu Chen, Shanmei Shen, Hongwei Wang, Qian Gao, Yong Wang
The ovary is the main regulator of female fertility. Granulosa cell dysfunction may be involved in various reproductive endocrine disorders. Here we investigated the effect of insulin resistance on the metabolism and function of ovarian granulosa cells, and dissected the functional status of the mitogen-activated protein kinase signaling pathway in these cells. Our data showed that dexamethasone-induced insulin resistance in mouse granulosa cells reduced insulin sensitivity, accompanied with an increase in phosphorylation of p44/42 mitogen-activated protein kinase...
2017: PloS One
https://www.readbyqxmd.com/read/29110315/nad-p-h-quinone-oxidoreductase-1-silencing-aggravates-hormone-induced-prostatic-hyperplasia-in-mice
#10
H-T Kim, Y-J Kim, S-R Park, S-Y Ryu, J-Y Jung
NAD(P)H-quinone oxidoreductase 1 (NQO1) is a highly inducible flavoprotein known to involve in various cellular defence mechanisms. In this study, we explored whether NQO1 deletion affects hormone-induced prostatic hyperplasia. Testosterone propionate (3 mg/kg, IP) was injected into wild-type (WT) and NOQ1 knockout C57BL/6 mice (NQO1(-/-) ) for 14 consecutive days, and the samples were collected for biological and histochemical studies. The testosterone-treated NQO1(-/-) showed about 140% higher prostate weight than the testosterone-treated WT, with enhanced connective tissue and hyperplastic glands formations...
November 6, 2017: Andrologia
https://www.readbyqxmd.com/read/29107901/enhanced-bio-concentration-of-tris-1-3-dichloro-2-propyl-phosphate-in-the-presence-of-nano-tio2-can-lead-to-adverse-reproductive-outcomes-in-zebrafish
#11
Xin Ren, Xuesong Zhao, Xiaoyue Duan, Ziwei Fang
Interactions between organic toxicants and nano-particles in the aquatic environment may modify toxicant bioavailability and consequently the toxicant's fate and toxicity. To evaluate the potential impact of nano-titanium dioxide (TiO2) on the bio-concentration and reproductive endocrine disruption of tris(1,3-dichloro-2-propyl) phosphate (TDCIPP) in fish, a comparative bioaccumulation study was conducted on zebrafish (Danio rerio, AB strain) treated with 0, 5.74, 23.6, or 90.7 μg L(-1) TDCIPP alone or co-exposed to TDCIPP and 0...
November 3, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/29092774/trkb-is-necessary-for-male-copulatory-behavior-in-the-syrian-hamster-mesocricetus-auratus
#12
Joe C Brague, Clifford Zinn, Dean Granot, Cameron T Feathers, Jennifer M Swann
The magnocellular medial preoptic nucleus (MPN mag), a subdivision of the medial preoptic area (MPOA), plays a critical role in the regulation of copulation in the Syrian hamster; in part by mediating the effects of gonadal steroids. For example, ablation of the MPN mag eliminates mating and testosterone placed in the MPN mag restores mating in castrated males. Testosterone treatment enhances synaptic density and dendritic spines in the MPN mag. Thus, copulatory behaviors are correlated with increases in synaptic morphology in the MPN mag...
October 29, 2017: Hormones and Behavior
https://www.readbyqxmd.com/read/29091864/taurine-enhances-spermatogenic-function-and-antioxidant-defense-mechanisms-in-testes-and-epididymis-of-l-name-induced-hypertensive-rats
#13
Isaac A Adedara, Sanmi E Alake, Mercy O Adeyemo, Laide O Olajide, Temitayo O Ajibade, Ebenezer O Farombi
The beneficial health effects of taurine on hypertension have been demonstrated previously in both experimental and epidemiological studies. However, the role of taurine in reproductive dysfunction associated with hypertension has not been investigated. The present study evaluated the therapeutic efficacy of taurine on reproductive deficits in N-nitro-l-arginine methyl ester (L-NAME)-induced hypertensive rats. Sixty male Wistar rats were randomly assigned into six groups namely control, taurine alone, L-NAME alone (40mg/kg) or L-NAME treated with either taurine (100 and 200mg/kg) or reference drug atenolol (10mg/kg) for 28 consecutive days...
October 26, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29090093/effects-of-pituitary-specific-overexpression-of-fsh%C3%AE-%C3%AE-on-reproductive-traits-in-transgenic-boars
#14
Wenting Li, Yujun Quan, Mengmeng Zhang, Kejun Wang, Muzhen Zhu, Ye Chen, Qiuyan Li, Keliang Wu
BACKGROUND: Follicle-stimulating hormone (FSH) is a gonadotropin synthesized and secreted by the pituitary gland. FSH stimulates follicle development and maturation in females. It also plays an important role in spermatogenesis in males, including humans and mice. However, the effects of FSH on male pigs are largely unknown. In this study, we generated transgenic pigs to investigate the effects of FSHα/β overexpression on reproductive traits in boars. RESULTS: After five transgenic F0 founders were crossed with wide-type pigs, 193 F1 animals were obtained...
2017: Journal of Animal Science and Biotechnology
https://www.readbyqxmd.com/read/29083935/tri-nucleotide-consortium-of-androgen-receptor-is-associated-with-low-serum-fsh-and-testosterone-in-asthenospermic-men
#15
Haroon Latif Khan, Shahzad Bhatti, Sana Abbas, Yousaf Latif Khan, Muhammad Aslamkhan, Rosa Maria Marquez Gonzalez, Gerardo Rodriguez Gonzalez, Hikmet Hakan Aydin, Magali Segundo Trinidad
Androgen mediating signaling is implicated in regulating the expression of reproductive related genes. Any deviation in the gene expression might be the ignitable precursor for genomic instability that inflames the genomic rearrangements and a leading cause of cancer. The main goal of this study was to determine the relationships between trinucleotide repeats of androgen receptor (AR), sex steroids, and sexual function in men presenting with reduced sperm motility. We investigated the singleton or combinatorial effects of the length of trinucleotide repeats of AR on reproductive hormones, clinical parameters, semen analyses, as well as sexual assessment function of 210 asthenospermic outpatients along with 125 normal subjects...
October 30, 2017: Systems Biology in Reproductive Medicine
https://www.readbyqxmd.com/read/29080463/ameliorative-effects-of-bee-pollen-and-date-palm-pollen-on-the-glycemic-state-and-male-sexual-dysfunctions-in-streptozotocin-induced-diabetic-wistar-rats
#16
Nema A Mohamed, Osama M Ahmed, Walaa G Hozayen, Marium A Ahmed
This study aimed to assess the effects of bee pollen (BP) and/or date palm pollen (DPP) suspensions on the glycemic state, testicular dysfunctions, oxidative stress and antioxidant defense system in streptozotocin (STZ)-induced diabetic male Wistar rats. Diabetes mellitus was induced by single intraperitoneal injection of STZ to overnight-fasted rats at dose of 40mg/kg body weight. After 1 week of STZ injection, diabetic rats were treated with BP and/or DPP suspensions at dose levels of 100mg/kg body weight/day for 4 weeks...
October 25, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29073541/melatonin-promotes-sheep-leydig-cell-testosterone-secretion-in-a-co-culture-with-sertoli-cells
#17
Shou-Long Deng, Zhi-Peng Wang, Cheng Jin, Xiao-Long Kang, Aalia Batool, Yan Zhang, Xiao-Yu Li, Xiu-Xia Wang, Su-Ren Chen, Chawn-Shang Chang, C Yan Cheng, Zheng-Xing Lian, Yi-Xun Liu
Leydig cells synthesize and secrete testosterone, and are regulated by Sertoli cells. These two cell types may work together to regulate testicular androgen production. Studies have shown that Leydig cell androgen synthesis can be dramatically enhanced by Sertoli cells in the presence of melatonin, which can regulate the secretory function of Leydig and Sertoli cells. However, the molecular mechanism of melatonin-regulated Leydig cell androgen production via Sertoli cells remains unclear. Here, we found that 10(-7) M melatonin increased testosterone production in co-cultured Leydig and Sertoli cells isolated from sheep...
October 17, 2017: Theriogenology
https://www.readbyqxmd.com/read/29073274/transcriptome-analysis-of-mrna-and-micrornas-in-intramuscular-fat-tissues-of-castrated-and-intact-male-chinese-qinchuan-cattle
#18
Ying-Ying Zhang, Hong-Bao Wang, Ya-Ning Wang, Hong-Cheng Wang, Song Zhang, Jie-Yun Hong, Hong-Fang Guo, Dai Chen, Yang Yang, Lin-Sen Zan
Intramuscular fat (IMF) is known to enhance beef palatability and can be markedly increased by castration. However, there is little understanding of the molecular mechanism underlying the IMF deposition after castration of beef cattle. We hypothesize that genetic regulators function differently in IMF from bulls and steers. Therefore, after detecting serum testosterone and lipid parameter, as well as the contents of IMF at 6, 12, 18 and 24 months, we have investigated differentially expressed (DE) microRNAs (miRNAs) and mRNAs in IMF of bulls and steers at 24 months of age in Qinchuan cattle using next-generation sequencing, and then explored the possible biopathways regulating IMF deposition...
2017: PloS One
https://www.readbyqxmd.com/read/29063642/neonatal-maternal-separation-opposes-the-facilitatory-effect-of-castration-on-the-respiratory-response-to-hypercapnia-of-the-adult-male-rat-evidence-for-the-involvement-of-the-medial-amygdala
#19
Luana Tenorio-Lopes, Mathilde S Henry, Danuzia Marques, Marie-Ève Tremblay, Guy Drolet, Frederic Bretzner, Richard Kinkead
Respiratory manifestations of panic disorder (PD) include a greater respiratory instability and enhanced responsiveness to CO2 compared to normal individuals. While the prevalence of PD is ~3 times greater in women compared with men, the origins of this sexual dimorphism remain poorly understood. Much like PD patients, adult female rats previously subjected to neonatal maternal separation (NMS) show an increase in their ventilatory response to CO2 . Because this effect of NMS is not observed in males, we hypothesized that testosterone prevents NMS-induced hyper-responsiveness to CO2 ...
October 24, 2017: Journal of Neuroendocrinology
https://www.readbyqxmd.com/read/29062601/effects-of-gnrha-treatment-during-vitellogenesis-on-the-reproductive-physiology-of-thermally-challenged-female-atlantic-salmon-salmo-salar
#20
Kelli Anderson, Ned Pankhurst, Harry King, Abigail Elizur
Tasmanian Atlantic salmon (S. salar) broodstock can experience temperatures above 20 °C, which impairs reproductive development and inhibits ovulation. The present study investigated the prolonged use of gonadotropin releasing hormone analogue (GnRHa) during vitellogenesis as a means of maintaining endocrine function and promoting egg quality at elevated temperature in maiden and repeat spawning S. salar. GnRHa-treatment during vitellogenesis did not compensate for the negative effects of thermal challenge on the timing of ovulation, egg size, egg fertility or embryo survival in any fish maintained at 22 °C relative to 14 °C...
2017: PeerJ
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