keyword
MENU ▼
Read by QxMD icon Read
search

Testosterone enhancing

keyword
https://www.readbyqxmd.com/read/28928235/testosterone-protects-high-fat-low-carbohydrate-diet-induced-non-alcoholic-fatty-liver-disease-in-castrated-male-rats-mainly-via-modulating-er-stress
#1
Yue Jia, Jennifer Kuang Yee, Christina Wang, Liana Nikolaenko, Maruja Diaz-Arjonilla, Joshua N Cohen, Samuel W French, Peter Y Liu, YanHe Lue, Wai-Nang Paul Lee, Ronald S Swerdloff
We previously showed that testosterone (T) deficiency enhanced high-fat diet (HFD) induced hepatic steatosis in rats that was independent of insulin resistance, and that T replacement reduced hepatic macrovesicular fat accumulation and inflammation. The present report explores the mechanism of T-protective effects on HFD-induced steatohepatitis. Adult male rats were randomized into four treatment groups for 15 weeks (intact rats on regular chow diet or HFD, and castrated rats on HFD with/without T replacement)...
September 19, 2017: American Journal of Physiology. Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28927970/hormonal-response-patterns-are-differentially-influenced-by-physical-conditioning-programs-during-basic-military-training
#2
Jace R Drain, Herbert Groeller, Simon D Burley, Bradley C Nindl
OBJECTIVES: Compare traditional military physical training and more contemporary physical training on catabolic and anabolic hormones and body composition in recruits undertaking basic military training (BMT). DESIGN: A prospective cross-sectional study design. METHODS: Two recruit intakes were assessed over the 12-week Australian Army BMT course. The control group (CON) comprised 40 recruits (26M/14F) and the experimental group (EXP) comprised 35 recruits (25M/10F)...
September 6, 2017: Journal of Science and Medicine in Sport
https://www.readbyqxmd.com/read/28919553/social-evaluative-threat-with-verbal-performance-feedback-alters-neuroendocrine-response-to-stress
#3
Jenny M Phan, Ekaterina Schneider, Jeremy Peres, Olga Miocevic, Vanessa Meyer, Elizabeth A Shirtcliff
Laboratory stress tasks such as the Trier Social Stress Test (TSST) have provided a key piece to the puzzle for how psychosocial stress impacts the hypothalamic-pituitary-adrenal axis, other stress-responsive biomarkers, and ultimately wellbeing. These tasks are thought to work through biopsychosocial processes, specifically social evaluative threat and the uncontrollability heighten situational demands. The present study integrated an experimental modification to the design of the TSST to probe whether additional social evaluative threat, via negative verbal feedback about speech performance, can further alter stress reactivity in 63 men and women...
September 15, 2017: Hormones and Behavior
https://www.readbyqxmd.com/read/28912255/sex-hormones-and-the-development-of-sexual-size-dimorphism-dihydrotestosterone-inhibits-growth-in-a-female-larger-lizard-sceloporus-undulatus
#4
Nicholas B Pollock, Stephanie Feigin, Marko Drazenovic, Henry B John-Alder
Sexual differences in adult body size (sexual size dimorphism; SSD) and color (sexual dichromatism) are widespread, and both male- and female-biased dimorphisms are observed even among closely related species. A growing body of evidence indicates testosterone (T) can regulate growth, thus the development of SSD, and sexual dichromatism. However, the mechanism(s) underlying these effects are conjectural, including possible conversions of T to estradiol (E2) or 5 α-dihydrotestosterone (DHT). In the present study, we hypothesized that effects of T are physiological responses mediated by androgen receptors, and we tested two specific predictions: 1) that DHT would mimic effects of T by inhibiting growth and enhancing coloration, and 2) that removal of endogenous T via surgical castration would stimulate growth...
September 14, 2017: Journal of Experimental Biology
https://www.readbyqxmd.com/read/28911778/applications-of-isotope-ratio-mass-spectrometry-in-sports-drug-testing-accounting-for-isotope-fractionation-in-analysis-of-biological-samples
#5
Thomas Piper, Mario Thevis
The misuse of anabolic-androgenic steroids (AAS) in sports aiming at enhancing athletic performance has been a challenging matter for doping control laboratories for decades. While the presence of a xenobiotic AAS or its metabolite(s) in human urine immediately represents an antidoping rule violation, the detection of the misuse of endogenous steroids such as testosterone necessitates comparably complex procedures. Concentration thresholds and diagnostic analyte ratios computed from urinary steroid concentrations of, e...
2017: Methods in Enzymology
https://www.readbyqxmd.com/read/28911172/androgens-mediate-sex-dependent-gonadotropin-expression-during-late-prenatal-development-in-the-mouse
#6
Michael J Kreisman, Christopher I Song, Kathleen Yip, Bryony V Natale, David R Natale, Kellie M Breen
Central organization of the hypothalamic-pituitary-gonadal axis is initiated during fetal life. At this critical time, gonadal hormones mediate sex-specific development of the hypothalamic-pituitary axis, which then dictates reproductive physiology and behavior in adulthood. Although studies have investigated the effects of prenatal androgens on central factors influencing gonadotropin-releasing hormone (GnRH) release, the impact of fetal androgens on gonadotrope function has been overlooked. In the current study, we demonstrated that gonadotropin gene expression and protein production were robustly elevated in female mice compared with males during late fetal development and that this sex difference was dependent on fetal androgens...
September 1, 2017: Endocrinology
https://www.readbyqxmd.com/read/28906379/accessory-ovarian-steroid-cell-tumor-producing-testosterone-and-cortisol-a-case-report
#7
Li Zang, Mingxia Ye, Guoqing Yang, Jinlong Li, Mei Liu, Jin Du, Weijun Gu, Nan Jin, Lijuan Yang, Jianming Ba, Jingtao Dou, Wensheng Fan, Yiming Mu, Yuanguang Meng, Zhaohui Lyu
RATIONALE: An accessory ovary is a rare structure containing normal ovarian tissue, which has a direct or ligamentous connection with a normal and eutopic ovary. PATIENT CONCERNS: In the study, we reported a 46-year-old woman presented with secondary amenorrhea and virilization symptoms for 1 year. DIAGNOSES: Endocrine evaluation revealed slightly elevated serum cortisol, extremely elevated 24-hour urinary-free cortisol and serum testosterone...
September 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28885585/hair-regenerative-mechanisms-of-red-ginseng-oil-and-its-major-components-in-the-testosterone-induced-delay-of-anagen-entry-in-c57bl-6-mice
#8
Van-Long Truong, Min Ji Bak, Changook Lee, Mira Jun, Woo-Sik Jeong
Hair loss (alopecia) is a universal problem for numerous people in the world. The present study was conducted to investigate the effects of red ginseng oil (RGO) and its major components on hair re-growth using testosterone (TES)-induced delay of anagen entry in C57BL/6 mice and their mechanisms of action. Seven-week-old C57BL/6 mice were daily treated with TES for 1 h prior to topical application of 10% RGO, 1% linoleic acid (LA), 1% β-sitosterol (SITOS), or 1% bicyclo(10.1.0)tridec-1-ene (BICYCLO) once a day for 28 days...
September 8, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28882815/childhood-tolerance-of-severe-influenza-a-mortality-analysis-in-mice
#9
Freeman Suber, Lester Kobzik
During the 1918 influenza pandemic, children experienced substantially lower mortality than adults, a striking but unexplained finding. Whether this was due to enhanced resistance (reduced virus load) or better tolerance (reduced impact of infection) has not been defined. We found that prepubertal mice infected with H1N1 influenza virus also showed greater survival than infected pubertal mice, despite similar virus loads. Transcriptome profiling of infected lungs identified estrogen as a regulator of susceptibility in both sexes, and also linked better survival to late expression of IL-1beta...
September 7, 2017: American Journal of Physiology. Lung Cellular and Molecular Physiology
https://www.readbyqxmd.com/read/28878336/effect-of-gnrhr-polymorphisms-on-in-vitro-fertilization-and-embryo-transfer-in-patients-with-polycystic-ovary-syndrome
#10
Wei-Yan Chen, Yan-Qiu Du, Xia Guan, Hong-Yun Zhang, Ting Liu
We investigated the relationship between gonadotropin-releasing hormone receptor (GnRHR) gene polymorphisms and outcome of patients with polycystic ovary syndrome (PCOS) undergoing in vitro fertilization and embryo transfer (IVF-ET). PCOS patients undergoing IVF-ET were selected, and infertile patients due to dysfunctional oviducts served as controls. GnRHR gene polymorphisms were detected using the polymerase chain reaction-restriction fragment length polymorphism assay. Gene-gene interaction and linkage disequilibrium tests were performed using the SHEsis software...
September 7, 2017: Journal of Human Genetics
https://www.readbyqxmd.com/read/28877400/glucocorticoid-receptor-is-involved-in-the-differential-expression-of-hepatic-3%C3%AE-hydroxysteroid-dehydrogenase-between-barrows-and-boars-at-finishing-stage
#11
Xian Li, Rihua Cong, Wen Yao, Yimin Jia, Runsheng Li, Zhiyuan Sun, Xi Li, Ruqian Zhao
The enzyme 3β-hydroxysteroid dehydrogenase (3β-HSD) plays an important role in androstenone metabolism in pig liver, and its defective expression is related to the development of boar taint. Early age castration is a common practice in many countries to avoid boar taint, yet whether and how castration affects porcine hepatic 3β-HSD expression are still poorly understood. In this study, we aimed to compare the expression of 3β-HSD between intact (boars) and castrated (barrows) male pigs, and to explore the potential factors regulating 3β-HSD transcription...
September 6, 2017: Animal Science Journal, Nihon Chikusan Gakkaihō
https://www.readbyqxmd.com/read/28865467/beneficial-effects-of-curcumin-nano-emulsion-on-spermatogenesis-and-reproductive-performance-in-male-rats-under-protein-deficient-diet-model-enhancement-of-sperm-motility-conservancy-of-testicular-tissue-integrity-cell-energy-and-seminal-plasma-amino-acids
#12
Omar A H Ahmed-Farid, Maha Nasr, Rania F Ahmed, Rofanda M Bakeer
BACKGROUND: Malnutrition resulting from protein and calorie deficiency continues to be a major concern worldwide especially in developing countries. Specific deficiencies in the protein intake can adversely influence reproductive performance. The present study aimed to evaluate the effects of curcumin and curcumin nano-emulsion on protein deficient diet (PDD)-induced testicular atrophy, troubled spermatogenesis and decreased reproductive performance in male rats. METHODS: Juvenile rats were fed the protein deficient diet (PDD) for 75 days...
September 2, 2017: Journal of Biomedical Science
https://www.readbyqxmd.com/read/28865351/exogenous-testosterone-enhances-cortisol-and-affective-responses-to-social-evaluative-stress-in-dominant-men
#13
Erik L Knight, Colton B Christian, Pablo J Morales, William T Harbaugh, Ulrich Mayr, Pranjal H Mehta
Stress often precedes the onset of mental health disorders and is linked to negative impacts on physical health as well. Prior research indicates that testosterone levels are related to reduced stress reactivity in some cases but correlate with increased stress responses in other cases. To resolve these inconsistencies, we tested the causal influence of testosterone on stress reactivity to a social-evaluative stressor. Further, prior work has failed to consider status-relevant individual differences such as trait dominance that may modulate the influence of testosterone on responses to stressors...
August 18, 2017: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/28844848/nano-sized-titanium-dioxide-toxicity-in-rat-prostate-and-testis-possible-ameliorative-effect-of-morin
#14
Nancy N Shahin, Maha M Mohamed
This study investigated the effect of short-term oral exposure to nano-sized titanium dioxide (nTiO2) on Wistar rat prostate and testis, and the associating reproductive-related alterations. The study also evaluated the potential ameliorative effect of the natural flavonoid, morin, on nTiO2-induced aberrations. Intragastric administration of nTiO2 (50mg/kg/day for 1, 2 and 3weeks) increased testicular gamma-glutamyltransferase (γ-GT) activity and decreased testicular steroidogenic acute regulatory protein (StAR) and c-kit gene expression, serum testosterone level and sperm count...
August 26, 2017: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/28831954/effects-of-different-dietary-dha-epa-ratios-on-gonadal-steroidogenesis-in-the-marine-teleost-tongue-sole-cynoglossus-semilaevis
#15
RANDOMIZED CONTROLLED TRIAL
Houguo Xu, Lin Cao, Yuliang Wei, Yuanqin Zhang, Mengqing Liang
The present study was conducted to investigate the effects of dietary DHA and EPA on gonadal steroidogenesis in mature females and males, with a feeding trial on tongue sole, a typical marine teleost with sexual dimorphism. Three experimental diets differing basically in DHA:EPA ratio, that is, 0·68 (diet D:E-0·68), 1·09 (D:E-1·09) and 2·05 (D:E-2·05), were randomly assigned to nine tanks of 3-year-old tongue sole (ten females and fifteen males in each tank). The feeding trail lasted for 90 d before and during the spawning season...
August 2017: British Journal of Nutrition
https://www.readbyqxmd.com/read/28811197/seasonal-changes-in-plasma-testosterone-and-cortisol-suggest-an-androgen-mediated-regulation-of-the-pituitary-adrenal-axis-in-the-tarabul-s-gerbil-gerbillus-tarabuli-thomas-1902
#16
Yamina Zatra, Naouel Aknoun-Sail, Arezki Kheddache, Abdelouafi Benmouloud, Salima Charallah, Elara N Moudilou, Jean-Marie Exbrayat, Farida Khammar, Zaina Amirat
In the desert gerbil Gerbillus tarabuli (Thomas, 1902), cortisol is the main glucocorticosteroid produced by the adrenal glands. Plasma cortisol concentrations show highest values when testosterone is reduced and lowest values during the breeding season which occurs from early winter to late spring. In order to specify the implication of testicular androgens in these corticosteroid seasonal variations we investigated the effects induced by gonadectomy performed during the breeding season on the pituitary adrenal axis...
August 12, 2017: General and Comparative Endocrinology
https://www.readbyqxmd.com/read/28748371/acute-effects-of-heated-resistance-exercise-in-female-and-male-power-athletes
#17
Julia R Casadio, Adam G Storey, Fabrice Merien, Andrew E Kilding, James D Cotter, Paul B Laursen
PURPOSE: To determine the effects of heated resistance exercise on thermal strain, neuromuscular function and hormonal responses in power athletes. METHODS: Sixteen (n = 8 female; 8 male) highly trained power athletes completed a combined strength and power resistance exercise session in hot (HOT ~30 °C) and temperate (CON ~20 °C) conditions. Human growth hormone (hGH), cortisol and testosterone concentrations in plasma, peak power (counter-movement jump, CMJ) and peak force (isometric mid-thigh pull) were measured before and after each training session; thermoregulatory responses were monitored during training...
July 26, 2017: European Journal of Applied Physiology
https://www.readbyqxmd.com/read/28743551/solubilizing-steroidal-drugs-by-%C3%AE-cyclodextrin-derivatives
#18
Dennis H Schwarz, Annegret Engelke, Gerhard Wenz
Administration of steroidal drugs is hampered by their very low solubilities in water. β-Cyclodextrin and β-cyclodextrin derivatives can solubilize steroids and improve bio-availability of these hydrophobic APIs. A systematic overview of the achievable solubility enhancements of various steroids, testosterone, estradiol, progesterone, hydrocortisone, prednisone, dexamethasone, and finasteride, is provided. Beside the spatial fit of the steroid within the cyclodextrin cavity also hydrophilic substituents at the cyclodextrin framework play an important role in the extent of solubilization observed...
July 22, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28741210/effects-of-bpf-on-steroid-hormone-homeostasis-and-gene-expression-in-the-hypothalamic-pituitary-gonadal-axis-of-zebrafish
#19
Qian Yang, Xianhai Yang, Jining Liu, Wenjuan Ren, Yingwen Chen, Shubao Shen
Bisphenol F (BPF) has been frequently detected in various environmental compartments, and previous studies found that BPF exhibits similar estrogenic and anti-androgenic effects on the mammalian endocrine system to those of bisphenol A (BPA). However, the potential disrupting effects of BPF on aquatic organisms and the underling disrupting mechanisms have not been investigated. In this study, the potential disrupting mechanisms of BPF on the hypothalamic-pituitary-gonadal (HPG) axis and liver were probed by employing the OECD 21-day short-term fecundity assay in zebrafish...
July 25, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28721614/low-doses-of-chlorpyrifos-interfere-with-spermatogenesis-of-rats-through-reduction-of-sex-hormones
#20
Dinithi Champika Peiris, Thamali Dhanushka
Use of pesticides results in indirect effects on human health. We aimed to evaluate implications of toxicological effects of subchronic chlorpyrifos exposure on reproductive function in male rats. A total of 48 adult Wistar male rats were separated into four groups (n = 12). Animals were gavaged with 2.5 mg/kg (T1), 5 mg/kg (T2), or 10 mg/kg (T3) body weight of chlorpyrifos (CPF) or distilled water (control) daily for 30 days. Organ weights, epididymal sperm parameters, DNA integrity, sex hormonal (FHS and LH) levels, and alanine aminotransferase (ALT), aspartate aminotransferase (AST), gamma-glutamyl transferase (GGT), and creatinine concentrations were determined on day 31...
July 18, 2017: Environmental Science and Pollution Research International
keyword
keyword
26191
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"