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https://www.readbyqxmd.com/read/28538307/can-cold-water-immersion-enhance-recovery-in-elite-olympic-weightlifters-an-individualized-perspective
#1
Jan Schimpchen, Maximilian Wagner, Alexander Ferrauti, Michael Kellmann, Mark Pfeiffer, Tim Meyer
Schimpchen, J, Wagner, M, Ferrauti, A, Kellmann, M, Pfeiffer, M, and Meyer, T. Can cold water immersion enhance recovery in elite Olympic weightlifters? An individualized perspective. J Strength Cond Res 31(6): 1569-1576, 2017-We investigated whether cold water immersion (CWI) after intensive training sessions can enhance recovery in elite Olympic weightlifters, taking into account each athlete's individual response pattern. The entire German male Olympic weightlifting national team participated in the study (n = 7), ensuring collection of data from elite athletes only...
June 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/28516454/a-multiscale-computational-modelling-approach-predicts-mechanisms-of-female-sex-risk-in-the-setting-of-arousal-induced-arrhythmias
#2
Pei-Chi Yang, Laura L Perissinotti, Fernando López-Redondo, Yibo Wang, Kevin R DeMarco, Mao-Tsuen Jeng, Igor Vorobyov, Robert D Harvey, Junko Kurokawa, Sergei Y Noskov, Colleen E Clancy
Female sex is a risk factor for inherited and acquired Long-QT associated Torsade de Pointes (TdP) arrhythmias, and sympathetic discharge is a major factor in triggering TdP in female Long-QT syndrome patients. We used a combined experimental and computational approach to predict 'the perfect storm' of hormone concentration, IKr block, and sympathetic stimulation that induces arrhythmia in females with inherited and acquired Long-QT. More specifically, we developed mathematical models of acquired and inherited Long-QT syndrome in male and female ventricular human myocytes by combining effects of a hormone and a hERG blocker dofetilide or hERG mutations...
May 18, 2017: Journal of Physiology
https://www.readbyqxmd.com/read/28501551/contribution-of-stress-and-sex-hormones-to-memory-encoding
#3
Christian J Merz
Distinct stages of the menstrual cycle and the intake of oral contraceptives (OC) affect sex hormone levels, stress responses, and memory processes critically involved in the pathogenesis of mental disorders. To characterize the interaction of sex and stress hormones on memory encoding, 30 men, 30 women in the early follicular phase of the menstrual cycle (FO), 30 women in the luteal phase (LU), and 30 OC women were exposed to either a stress (socially evaluated cold-pressor test) or a control condition prior to memory encoding and immediate recall of neutral, positive, and negative words...
May 6, 2017: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/28480685/hormonal-responses-to-a-rugby-match-a-brief-review
#4
Maamer Slimani, Foued Cheour, Wassim Moalla, Julien S Baker
BACKGROUND: Rugby is an intermittent team sport, commonly stressing the endocrine system by physiological efforts. However, no review has synthesized the available literature on the hormonal responses to a rugby match. The purpose of this review was to examine the hormonal responses to a rugby match. Mediator and moderator variables for the rugby match- hormonal responses relationship were also discussed. METHODS: The systematic search was conducted using different databases and according to the Population/Intervention or Exposure/Comparison/Outcome(s) [PICO] criteria...
May 5, 2017: Journal of Sports Medicine and Physical Fitness
https://www.readbyqxmd.com/read/28480429/ethnobotanical-survey-of-phoenix-dactylifera-l-pollen-used-for-the-treatment-of-infertility-problems-in-algerian-oases
#5
Cherifa Selmani, Djamila Chabane, Nadia Bouguedoura
BACKGROUND: The Phoenix dactylifera L. (date palm) is known for its traditional medicinal properties across the history of native population in Algerian Sahara. There is a large trend of consumption of date palm pollen preparations in many human infertility cases in our country. However, the validity has not been scientifically tested. There has been no direct scientific research on this application. This study was undertaken to identify cultivars with greater potential in the traditional medicine uses...
2017: African Journal of Traditional, Complementary, and Alternative Medicines: AJTCAM
https://www.readbyqxmd.com/read/28475120/protective-effect-of-fragaria-ananassa-crude-extract-on-cadmium-induced-lipid-peroxidation-antioxidant-enzymes-suppression-and-apoptosis-in-rat-testes
#6
Mohammed I Y Elmallah, Manal F Elkhadragy, Ebtesam M Al-Olayan, Ahmed E Abdel Moneim
Cadmium is a deleterious environmental pollutant that threats both animals and human health. Oxidative stress and elevated levels of reactive oxygen species (ROS) have recently been reported to be the main cause of cellular damage as a result of cadmium exposure. We investigate, here, the protective effect of strawberry crude extracts on cadmium-induced oxidative damage of testes in rats. Four groups (n = 8) of 32 adult male Wistar rats weighing 160-180 g were used. The control group received 0.9% saline solution all over the experimental period (5 days)...
May 5, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28469921/gonadotrophin-abnormalities-in-an-infant-with-lowe-syndrome
#7
Bronwen E Warner, Carol D Inward, Christine P Burren
SUMMARY: This case, presenting with bilateral impalpable testes, illustrates the relevance of a broad differential disorders of sex development case management. It provides new insights on hypothalamic-pituitary-gonadal (HPG) axis and testicular function abnormalities in the multisystem disorder of Lowe syndrome. Lowe syndrome, also known as oculocerebrorenal syndrome, is a rare disorder characterised by eye abnormalities, central nervous system involvement and proximal renal tubular acidosis...
2017: Endocrinology, Diabetes & Metabolism Case Reports
https://www.readbyqxmd.com/read/28453740/enhanced-coupling-within-gonadotropic-and-adrenocorticotropic-axes-by-moderate-exercise-in-healthy-men
#8
Ferdinand Roelfsema, Rebecca J Yang, Thomas P Olson, Michael J Joyner, Paul Y Takahashi, Johannes D Veldhuis
Context: Exercise elicits incompletely defined adaptations of metabolic and endocrine milieu, including the gonadotropic and the corticotropic axes. Objective: To quantify the impact of acute exercise on coordinate LH and testosterone and ACTH and cortisol secretion in healthy men in relation to age. Participantsand design: Prospectively randomized, within-subject cross-over, study in 23 men, aged 19-77 yr. Subjects underwent rest and 30 min of mixed exercise at 65% of maximal aerobic capacity with 10-min blood sampling between 0700 and 1300 h 2 wks apart...
April 27, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28435048/morella-serrata-lam-killick-stabilizes-biomembrane-and-rejuvenates-sexual-competence-in-male-wistar-rats
#9
S Sabiu, Aot Ashafa
ETHNOPHARMACOLOGICAL RELEVANCE: Morella serrata L. is an indigenous medicinal plant to South and southern Africa with folkloric applications as aphrodisiac, laxative, antimicrobial, anti-inflammatory, analgesic, anti-hypertensive, antitussive and antidiabetic agent. AIM OF THE STUDY: This study evaluated the membrane stabilization and aphrodisiac potentials of its aqueous root extract in male Wistar rats. MATERIALS AND METHODS: While the membrane stabilization of the extract was investigated against bovine erythrocytes (BE), the male rats for the aphrodisiac study were randomized into five groups with animals in group 1 given sterile placebo and served as control...
April 20, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28404691/exemestane-and-its-active-metabolite-17-hydroexemestane-induce-udp-glucuronosyltransferase-ugt-2b17-expression-in-breast-cancer-cells
#10
Apichaya Chanawong, Peter Ian Mackenzie, Ross A McKinnon, Dong Gui Hu, Robyn Meech
Exemestane (EXE) is an aromatase inhibitor indicated for endocrine therapy of breast cancer in post-menopausal women. The primary active metabolite of EXE, 17-hydroexemestane (17-HE), is inactivated via glucuronidation, mainly by UGT2B17. UGT2B17 also has a primary role in inactivation of endogenous androgens testosterone and dihydrotestosterone (DHT) and may play an important role in regulation of breast and prostate tumour intracrinology. We recently reported that UGT2B17 could be induced by both estrogenic and androgenic ligands in breast cancer cells via binding of the estrogen receptor alpha (ERα) or the androgen receptor (AR) to a complex regulatory unit in the proximal UGT2B17 promoter...
April 12, 2017: Journal of Pharmacology and Experimental Therapeutics
https://www.readbyqxmd.com/read/28398617/citalopram-induces-reproductive-toxicity-in-male-rats
#11
Sinem Ilgin, Gozde Kilic, Merve Baysal, Volkan Kilic, Busra Korkut, Seyda Ucarcan, Ozlem Atli
BACKGROUND: Citalopram hydrobromide (CTL) has been shown to cause sexual dysfunction; however, its reproductive toxicity potential has not been sufficiently elucidated in men. Therefore, we aimed to clarify the toxic effects of CTL on the reproductive system of male rats. METHODS: For this purpose, CTL was administered at 5, 10, and 20 mg/kg/day to rats orally for 28 days. Sperm concentration, motility, and morphology were investigated using a computer-assisted sperm analysis system, and sperm DNA damage was detected using a Comet assay...
April 17, 2017: Birth Defects Res
https://www.readbyqxmd.com/read/28390404/increase-of-glutathione-testosterone-and-antioxidant-effects-of-jurenia-dolomiaea-on-ccl4-induced-testicular-toxicity-in-rat
#12
Naseer Ali Shah, Muhammad Rashid Khan
BACKGROUND: Root of Jurenia dolomiaea is used traditionally in various disorders involving oxidative injuries i.e. rheumatism, gout and as stimulant. Earlier we have investigated in vitro antioxidant and DNA protective ability. In this investigation we have evaluated protective potential of J. dolomiaea root against the oxidative injuries induced with carbon tetrachloride (CCl4) in testes of rat. METHODS: Dried roots of J. dolomiaea were powdered and extracted with 95% methanol and residue was fractionated in escalating polarity of solvents...
April 8, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28388831/estrogen-signaling-is-necessary-for-exercise-mediated-enhancement-of-motoneuron-participation-in-axon-regeneration-after-peripheral-nerve-injury-in-mice
#13
Melina C Acosta, Patricia A Copley, Jamie R Harrell, Jennifer C Wilhelm
Thousands of people each year suffer from peripheral nerve injury. Treatment options are limited, and recovery is often incomplete. Treadmill exercise can enhance nerve regeneration; however, this appears to occur in a sex-dependent manner. Females respond best to short duration, high speed interval training; whereas, males respond best to slower, continuous training. Previous studies have shown a role for testosterone in this process, but the role of estrogen is unknown. To evaluate the role of estrogen signaling in treadmill exercise, we blocked estrogen receptor (ER) signaling during treadmill exercise in males and female wild type mice...
April 7, 2017: Developmental Neurobiology
https://www.readbyqxmd.com/read/28385400/nanomicelle-curcumin-induced-dna-fragmentation-in-testicular-tissue-correlation-between-mitochondria-dependent-apoptosis-and-failed-pcna-related-hemostasis
#14
Sana Moshari, Vahid Nejati, Gholamreza Najafi, Mazdak Razi
Current study was done to assess possible anti-proliferative effect of nanomicelle curcumin (NMCM) against germ cells in testicular tissue. For this purpose, 24 mature male Wistar rats were divided into control and test groups. The animals in test groups received 7.5mg/kg, 15mg/kg and 30mg/kg of NMC (NO=6 rats in each group). Following 48days, the expression of Bcl-2, Bax, caspase-3, P53 and proliferating cell nuclear antigen (PCNA) were evaluated by using reverse transcription-PCR and immunohistochemistry...
April 3, 2017: Acta Histochemica
https://www.readbyqxmd.com/read/28373640/a-high-fat-diet-impairs-reproduction-by-decreasing-the-il1%C3%AE-level-in-mice-treated-at-immature-stage
#15
Jie Zhang, Kai Li, Miao Yuan, Jie Zhang, Guizen Huang, Jie Ao, Haoze Tan, Yanyan Li, Di Gong, Jun Li, Lei Kang, Nini An, Fei Li, Ping Lin, Lugang Huang
Obesity causes low-grade inflammation that is involved in male infertility. Interleukin 1 beta (IL1β) plays an important role in this process. A high-fat diet (HFD) is the most common cause of obesity. However, the effect of a HFD on IL1β and its consequence in reproduction remain unclear. We established a HFD model in mice treated at immature stage (mice-TIS) and mice treated at mature stage (mice-TMS). Surprisingly, we found that a HFD decreased IL1β levels and was accompanied by an increase in testosterone in mice-TIS, while the reverse results were observed in mice-TMS...
April 3, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28368782/yoga-stretching-for-improving-salivary-immune-function-and-mental-stress-in-middle-aged-and-older-adults
#16
Nobuhiko Eda, Hironaga Ito, Kazuhiro Shimizu, Satomi Suzuki, Eunjae Lee, Takao Akama
Protection against age-related immune suppression is important in elderly individuals. This study determined the effect of yoga on mucosal immune function and mental stress. Saliva samples were collected from 23 adult women (age: 60.4 ± 10.4 years) before and after 90 minutes of yoga stretching or rest to measure secretory immunoglobulin A (SIgA), cortisol, and testosterone. The SIgA concentration and secretion rate were significantly higher after yoga than before (p < .05). The cortisol concentration and secretion rate were lower and testosterone secretion rate higher after yoga (p < ...
April 3, 2017: Journal of Women & Aging
https://www.readbyqxmd.com/read/28363857/oil-in-water-microemulsions-stabilized-by-3-n-n-dimethylalkylammonio-propanesulfonate-surfactants-of-varying-alkyl-chain-length-solubilisation-of-testos-terone-propionate
#17
Chien-Ming Hsieh, Warangkana Warisnoicharoen, Raju K Patel, Farnoosh Kianfar, M Jayne Lawrence
Solubilisation of the poorly-water soluble drug, testosterone propionate, in co-surfactant-free, dilutable, oil-in-water microemulsions stabilized by zwitterionic surfactants of varying alkyl chain length, namely 3-(N,N-dimethyloctylammonio)propanesulfonate and 3-(N,N-dimethyldodecylammonio)propanesulfonate and containing one of four ethyl ester oils, has been investigated. Both 3-(N,N-dimethyloctylammonio)propanesulfonate and 3-(N,N-dimethyldodecylammonio)propanesulfonate-stabilized microemulsions containing two short chain length oils, ethyl butyrate and ethyl caprylate, while only 3-(N,N-dimethyldodecylammonio)propanesulfonate formed microemulsions incorporating the longer chain length oils, ethyl palmitate and ethyl oleate, albeit to a very much reduced extent...
March 29, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28359952/low-testosterone-levels-are-related-to-oxidative-stress-mitochondrial-dysfunction-and-altered-subclinical-atherosclerotic-markers-in-type-2-diabetic-male-patients
#18
Susana Rovira-Llopis, Celia Bañuls, Aranzazu M de Marañon, Noelia Diaz-Morales, Ana Jover, Sandra Garzon, Milagros Rocha, Victor M Victor, Antonio Hernandez-Mijares
INTRODUCTION: Low testosterone levels in men are associated with type 2 diabetes and cardiovascular risk. However, the role of testosterone in mitochondrial function and leukocyte-endothelium interactions is unknown. Our aim was to evaluate the relationship between testosterone levels, metabolic parameters, oxidative stress, mitochondrial function, inflammation and leukocyte-endothelium interactions in type 2 diabetic patients. MATERIALS AND METHODS: The study was performed in 280 male type 2 diabetic patients and 50 control subjects...
March 27, 2017: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/28359799/paxillin-and-embryonic-polyadenylation-binding-protein-epabp-engage-to-regulate-androgen-dependent-xenopus-laevis-oocyte-maturation-a-model-of-kinase-dependent-regulation-of-protein-expression
#19
Susanne U Miedlich, Manisha Taya, Melissa Rasar Young, Stephen R Hammes
Steroid-triggered Xenopus laevis oocyte maturation is an elegant physiologic model of nongenomic steroid signaling, as it proceeds completely independent of transcription. We previously demonstrated that androgens are the main physiologic stimulator of oocyte maturation in Xenopus oocytes, and that the adaptor protein paxillin plays a crucial role in mediating this process through a positive feedback loop in which paxillin first enhances Mos protein translation, ensued by Erk2 activation and Erk-dependent phosphorylation of paxillin on serine residues...
March 28, 2017: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/28352339/determination-of-dna-damage-and-telomerase-activity-in-stanozolol-treated-rats
#20
Mehtap Kara, Eren Ozcagli, Persefoni Fragkiadaki, Tugba Kotil, Polychronis D Stivaktakis, Demetrios A Spandidos, Aristides M Tsatsakis, Buket Alpertunga
Anabolic androgenic steroids (AAS) are performance-enhancing drugs commonly abused by atheletes. Stanozolol is a synthetic testosterone-derived anabolic steroid. Although it is well known that AAS have several side-effects, there are only few toxicological studies available on the toxic effects and mechanisms of action of stanozolol. The aim of this study was to investigate the genotoxic effects of stanozolol and to determine its effects on telomerase activity in Sprague-Dawley male rats. For this purpose, 34 male rats were divided into 5 groups as follows: i) the control group (n=5); ii) the propylene glycol (PG)-treated group (n=5); iii) the stanozolol-treated group (n=8); iv) the PG-treated group subjected to exercise (n=8); and v) the stanozolol-treated group subjected to exercise (n=8)...
February 2017: Experimental and Therapeutic Medicine
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