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https://www.readbyqxmd.com/read/28915902/development-and-clinical-application-of-radiomics-in-lung-cancer
#1
REVIEW
Bojiang Chen, Rui Zhang, Yuncui Gan, Lan Yang, Weimin Li
Since the discovery of X-rays at the end of the 19(th) century, medical imageology has progressed for 100 years, and medical imaging has become an important auxiliary tool for clinical diagnosis. With the launch of the human genome project (HGP) and the development of various high-throughput detection techniques, disease exploration in the post-genome era has extended beyond investigations of structural changes to in-depth analyses of molecular abnormalities in tissues, organs and cells, on the basis of gene expression and epigenetics...
September 15, 2017: Radiation Oncology
https://www.readbyqxmd.com/read/28889246/the-preliminary-radiogenomics-association-between-mr-perfusion-imaging-parameters-and-genomic-biomarkers-and-their-predictive-performance-of-overall-survival-in-patients-with-glioblastoma
#2
Xiang Liu, Rajiv Mangla, Wei Tian, Xing Qiu, Dongmei Li, Kevin A Walter, Sven Ekholm, Mahlon D Johnson
The radiogenomics association of neovascularization is important for overall survival (OS) in glioblastoma patients and remains unclear. The purpose of this study is to assess the association between MR perfusion imaging derived parameters and genomic biomarkers of glioblastoma, and to evaluate their prognostic value. This retrospective study enrolled 41 patients with newly diagnosed glioblastoma. The mean and maximal relative cerebral blood volume (rCBV) ratio (rCBVmean and rCBVmax), derived from MR perfusion weighted imaging, of the enhancing tumor, as well as maximal rCBV ratio of peri-enhancing tumor area (rCBVperi-tumor) were measured...
September 9, 2017: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/28885890/qualitative-radiogenomics-association-between-oncotype-dx-test-recurrence-score-and-bi-rads-mammographic-and-breast-mr-imaging-features
#3
Genevieve A Woodard, Kimberly M Ray, Bonnie N Joe, Elissa R Price
Purpose To evaluate the association between Breast Imaging Reporting and Data System (BI-RADS) mammographic and magnetic resonance (MR) imaging features and breast cancer recurrence risk in patients with estrogen receptor-positive breast cancer who underwent the Oncotype DX assay. Materials and Methods In this institutional review board-approved and HIPAA-compliant protocol, 408 patients diagnosed with invasive breast cancer between 2004 and 2013 who underwent the Oncotype DX assay were identified. Mammographic and MR imaging features were retrospectively collected according to the BI-RADS lexicon...
September 8, 2017: Radiology
https://www.readbyqxmd.com/read/28872634/advancing-the-cancer-genome-atlas-glioma-mri-collections-with-expert-segmentation-labels-and-radiomic-features
#4
Spyridon Bakas, Hamed Akbari, Aristeidis Sotiras, Michel Bilello, Martin Rozycki, Justin S Kirby, John B Freymann, Keyvan Farahani, Christos Davatzikos
Gliomas belong to a group of central nervous system tumors, and consist of various sub-regions. Gold standard labeling of these sub-regions in radiographic imaging is essential for both clinical and computational studies, including radiomic and radiogenomic analyses. Towards this end, we release segmentation labels and radiomic features for all pre-operative multimodal magnetic resonance imaging (MRI) (n=243) of the multi-institutional glioma collections of The Cancer Genome Atlas (TCGA), publicly available in The Cancer Imaging Archive (TCIA)...
September 5, 2017: Scientific Data
https://www.readbyqxmd.com/read/28865512/radiogenomics-identification-of-genomic-predictors-for-radiation-toxicity
#5
REVIEW
Barry S Rosenstein
The overall goal of radiogenomics is the identification of genomic markers that are predictive for the development of adverse effects resulting from cancer treatment with radiation. The principal rationale for a focus on toxicity in radiogenomics is that for many patients treated with radiation, especially individuals diagnosed with early-stage cancers, the survival rates are high, and therefore a substantial number of people will live for a significant period of time beyond treatment. However, many of these patients could suffer from debilitating complications resulting from radiotherapy...
October 2017: Seminars in Radiation Oncology
https://www.readbyqxmd.com/read/28804537/an-integrated-approach-to-coronary-heart-disease-diagnosis-and-clinical-management
#6
REVIEW
Teresa Infante, Ernesto Forte, Concetta Schiano, Carlo Cavaliere, Carlo Tedeschi, Andrea Soricelli, Marco Salvatore, Claudio Napoli
The major issue in coronary heart disease (CHD) diagnosis and management is that symptoms onset in an advanced state of disease. Despite the availability of several clinical risk scores, the prediction of cardiovascular events is lacking, and many patients at risk are not well stratified according to the canonical risk factors alone. Therefore, adequate risk assessment remains the most challenging issue. Recently, the integration of imaging data with biochemical markers in a radiogenomic framework has been proposed in many fields of medicine as well as in cardiology...
2017: American Journal of Translational Research
https://www.readbyqxmd.com/read/28755054/mri-features-can-predict-egfr-expression-in-lower-grade-gliomas-a-voxel-based-radiomic-analysis
#7
Yiming Li, Xing Liu, Kaibin Xu, Zenghui Qian, Kai Wang, Xing Fan, Shaowu Li, Yinyan Wang, Tao Jiang
OBJECTIVE: To identify the magnetic resonance imaging (MRI) features associated with epidermal growth factor (EGFR) expression level in lower grade gliomas using radiomic analysis. METHODS: 270 lower grade glioma patients with known EGFR expression status were randomly assigned into training (n=200) and validation (n=70) sets, and were subjected to feature extraction. Using a logistic regression model, a signature of MRI features was identified to be predictive of the EGFR expression level in lower grade gliomas in the training set, and the accuracy of prediction was assessed in the validation set...
July 28, 2017: European Radiology
https://www.readbyqxmd.com/read/28727543/non-small-cell-lung-cancer-radiogenomics-map-identifies-relationships-between-molecular-and-imaging-phenotypes-with-prognostic-implications
#8
Mu Zhou, Ann Leung, Sebastian Echegaray, Andrew Gentles, Joseph B Shrager, Kristin C Jensen, Gerald J Berry, Sylvia K Plevritis, Daniel L Rubin, Sandy Napel, Olivier Gevaert
Purpose To create a radiogenomic map linking computed tomographic (CT) image features and gene expression profiles generated by RNA sequencing for patients with non-small cell lung cancer (NSCLC). Materials and Methods A cohort of 113 patients with NSCLC diagnosed between April 2008 and September 2014 who had preoperative CT data and tumor tissue available was studied. For each tumor, a thoracic radiologist recorded 87 semantic image features, selected to reflect radiologic characteristics of nodule shape, margin, texture, tumor environment, and overall lung characteristics...
July 20, 2017: Radiology
https://www.readbyqxmd.com/read/28723484/update-on-radiogenomics-of-clear-cell-renal-cell-carcinoma
#9
Francesco Alessandrino, Katherine M Krajewski, Atul B Shinagare
The goal of radiogenomics is to associate imaging features with gene expression pattern and correlate these features with clinical outcomes. Radiogenomics, by overcoming the histologic heterogeneity of clear cell renal cell carcinoma, has the potential to reflect tumor biology and predict prognosis.
December 15, 2016: European Urology Focus
https://www.readbyqxmd.com/read/28723287/advanced-renal-cell-carcinoma-role-of-the-radiologist-in-the-era-of-precision-medicine
#10
REVIEW
Atul B Shinagare, Katherine M Krajewski, Marta Braschi-Amirfarzan, Nikhil H Ramaiya
For the past decade, advanced renal cell carcinoma (RCC) has been at the forefront of oncologic innovation. Our rapidly evolving understanding of the molecular and genetic basis of RCC has revolutionized the management of advanced RCC; 10 novel molecular targeted agents and immune checkpoint inhibitor have received U.S. Food and Drug Administration approval for treatment of advanced RCC in a little over a decade. Amid this progress, imaging has assumed a central role in metastatic surveillance and follow-up of advanced RCC...
August 2017: Radiology
https://www.readbyqxmd.com/read/28723281/imaging-correlates-of-adult-glioma-genotypes
#11
REVIEW
Marion Smits, Martin J van den Bent
Primary brain tumors, most commonly gliomas, are histopathologically typed and graded as World Health Organization (WHO) grades I-IV according to increasing degrees of malignancy. These grades provide prognostic information and guidance on treatment such as radiation therapy and chemotherapy after surgery. Despite the confirmed value of the WHO grading system, results of a multitude of studies and prospective interventional trials now indicate that tumors with identical morphologic criteria can have highly different outcomes...
August 2017: Radiology
https://www.readbyqxmd.com/read/28717412/diffusion-magnetic-resonance-imaging-a-molecular-imaging-tool-caught-between-hope-hype-and-the-real-world-of-personalized-oncology
#12
REVIEW
Abhishek Mahajan, Sneha S Deshpande, Meenakshi H Thakur
"Personalized oncology" is a multi-disciplinary science, which requires inputs from various streams for optimal patient management. Humongous progress in the treatment modalities available and the increasing need to provide functional information in addition to the morphological data; has led to leaping progress in the field of imaging. Magnetic resonance imaging has undergone tremendous progress with various newer MR techniques providing vital functional information and is becoming the cornerstone of "radiomics/radiogenomics"...
June 28, 2017: World Journal of Radiology
https://www.readbyqxmd.com/read/28708462/heterogeneous-enhancement-patterns-of-tumor-adjacent-parenchyma-at-mr-imaging-are-associated-with-dysregulated-signaling-pathways-and-poor-survival-in-breast-cancer
#13
Jia Wu, Bailiang Li, Xiaoli Sun, Guohong Cao, Daniel L Rubin, Sandy Napel, Debra M Ikeda, Allison W Kurian, Ruijiang Li
Purpose To identify the molecular basis of quantitative imaging characteristics of tumor-adjacent parenchyma at dynamic contrast material-enhanced magnetic resonance (MR) imaging and to evaluate their prognostic value in breast cancer. Materials and Methods In this institutional review board-approved, HIPAA-compliant study, 10 quantitative imaging features depicting tumor-adjacent parenchymal enhancement patterns were extracted and screened for prognostic features in a discovery cohort of 60 patients. By using data from The Cancer Genome Atlas (TCGA), a radiogenomic map for the tumor-adjacent parenchymal tissue was created and molecular pathways associated with prognostic parenchymal imaging features were identified...
July 14, 2017: Radiology
https://www.readbyqxmd.com/read/28687979/-radio-oncomics-the-potential-of-radiomics-in-radiation-oncology
#14
Jan Caspar Peeken, Fridtjof Nüsslin, Stephanie E Combs
INTRODUCTION: Radiomics, a recently introduced concept, describes quantitative computerized algorithm-based feature extraction from imaging data including computer tomography (CT), magnetic resonance imaging (MRT), or positron-emission tomography (PET) images. For radiation oncology it offers the potential to significantly influence clinical decision-making and thus therapy planning and follow-up workflow. METHODS: After image acquisition, image preprocessing, and defining regions of interest by structure segmentation, algorithms are applied to calculate shape, intensity, texture, and multiscale filter features...
July 7, 2017: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
https://www.readbyqxmd.com/read/28657906/radiogenomics-and-radiotherapy-response-modeling
#15
Issam El Naqa, Sarah L Kerns, James Coates, Yi Luo, Corey Speers, Catharine M L West, Barry S Rosenstein, Randall K Ten Haken
Advances in patient-specific information and biotechnology have contributed to a new era of computational medicine. Radiogenomics has emerged as a new field that investigates the role of genetics in treatment response to radiation therapy. Radiation oncology is currently attempting to embrace these recent advances and add to its rich history by maintaining its prominent role as a quantitative leader in oncologic response modeling. Here, we provide an overview of radiogenomics starting with genotyping, data aggregation, and application of different modeling approaches based on modifying traditional radiobiological methods or application of advanced machine learning techniques...
August 1, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28641043/radiogenomics-of-high-grade-serous-ovarian-cancer-multireader-multi-institutional-study-from-the-cancer-genome-atlas-ovarian-cancer-imaging-research-group
#16
Hebert Alberto Vargas, Erich P Huang, Yulia Lakhman, Joseph E Ippolito, Priya Bhosale, Vincent Mellnick, Atul B Shinagare, Maria Anello, Justin Kirby, Brenda Fevrier-Sullivan, John Freymann, C Carl Jaffe, Evis Sala
Purpose To evaluate interradiologist agreement on assessments of computed tomography (CT) imaging features of high-grade serous ovarian cancer (HGSOC), to assess their associations with time-to-disease progression (TTP) and HGSOC transcriptomic profiles (Classification of Ovarian Cancer [CLOVAR]), and to develop an imaging-based risk score system to predict TTP and CLOVAR profiles. Materials and Methods This study was a multireader, multi-institutional, institutional review board-approved, HIPAA-compliant retrospective analysis of 92 patients with HGSOC (median age, 61 years) with abdominopelvic CT before primary cytoreductive surgery available through the Cancer Imaging Archive...
June 22, 2017: Radiology
https://www.readbyqxmd.com/read/28596154/3d-printed-pathological-sectioning-boxes-to-facilitate-radiological-pathological-correlation-in-hepatectomy-cases
#17
Andrew T Trout, Matthew R Batie, Anita Gupta, Rachel M Sheridan, Gregory M Tiao, Alexander J Towbin
Radiogenomics promises to identify tumour imaging features indicative of genomic or proteomic aberrations that can be therapeutically targeted allowing precision personalised therapy. An accurate radiological-pathological correlation is critical to the process of radiogenomic characterisation of tumours. An accurate correlation, however, is difficult to achieve with current pathological sectioning techniques which result in sectioning in non-standard planes. The purpose of this work is to present a technique to standardise hepatic sectioning to facilitateradiological-pathological correlation...
June 8, 2017: Journal of Clinical Pathology
https://www.readbyqxmd.com/read/28470431/radiogenomics-of-lower-grade-glioma-algorithmically-assessed-tumor-shape-is-associated-with-tumor-genomic-subtypes-and-patient-outcomes-in-a-multi-institutional-study-with-the-cancer-genome-atlas-data
#18
Maciej A Mazurowski, Kal Clark, Nicholas M Czarnek, Parisa Shamsesfandabadi, Katherine B Peters, Ashirbani Saha
Recent studies identified distinct genomic subtypes of lower-grade gliomas that could potentially be used to guide patient treatment. This study aims to determine whether there is an association between genomics of lower-grade glioma tumors and patient outcomes using algorithmic measurements of tumor shape in magnetic resonance imaging (MRI). We analyzed preoperative imaging and genomic subtype data from 110 patients with lower-grade gliomas (WHO grade II and III) from The Cancer Genome Atlas. Computer algorithms were applied to analyze the imaging data and provided five quantitative measurements of tumor shape in two and three dimensions...
May 3, 2017: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/28453432/multiregional-radiogenomic-assessment-of-prostate-microenvironments-with-multiparametric-mr-imaging-and-dna-whole-exome-sequencing-of-prostate-glands-with-adenocarcinoma
#19
Neema Jamshidi, Daniel J Margolis, Steven Raman, Jiaoti Huang, Robert E Reiter, Michael D Kuo
Purpose To assess the underlying genomic variation of prostate gland microenvironments of patients with prostate adenocarcinoma in the context of colocalized multiparametric magnetic resonance (MR) imaging and histopathologic assessment of normal and abnormal regions by using whole-exome sequencing. Materials and Methods Six patients with prostate adenocarcinoma who underwent robotic prostatectomy with whole-mount preservation of the prostate were identified, which enabled spatial mapping between preoperative multiparametric MR imaging and the gland...
July 2017: Radiology
https://www.readbyqxmd.com/read/28418819/cancer-genomics-and-important-oncologic-mutations-a-contemporary-guide-for-body-imagers
#20
REVIEW
Veronica L Cox, Priya Bhosale, Gauri R Varadhachary, Nicolaus Wagner-Bartak, Isabella C Glitza, Kathryn A Gold, Johnique T Atkins, Pamela T Soliman, David S Hong, Aliya Qayyum
The field of cancer genomics is rapidly evolving and has led to the development of new therapies. Knowledge of commonly involved cellular pathways and genetic mutations is now essential for radiologists reading oncology cases. Radiogenomics is an emerging area of research that seeks to correlate imaging features with cancer genotypes. Such knowledge may extend the utility of multiparametric imaging to yield information regarding cancer prognosis and likelihood of therapeutic response. To date, only a handful of radiogenomics studies have been performed to evaluate solid tumors of the body, and there is much to explore...
May 2017: Radiology
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