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Repeated pregnancy losses

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https://www.readbyqxmd.com/read/29457113/pulmonary-embolism-caused-by-ovarian-vein-thrombosis-during-cesarean-section-a-case-report
#1
Yutaka Oda, Michie Fujita, Chika Motohisa, Shinichi Nakata, Motoko Shimada, Ryushi Komatsu
Background: Ovarian vein thrombosis is a rare complication of pregnancy. The representative complaints of patients with ovarian vein thrombosis are abdominal pain and fever. In some cases, however, fatal pulmonary embolism may develop. We report a case of pulmonary embolism presenting with severe hypotension and loss of consciousness during cesarean section possibly caused by ovarian vein thrombosis. Case presentation: A 25-year-old woman at 38 weeks 4 days of gestation was scheduled for repeat cesarean section...
2018: JA Clin Rep
https://www.readbyqxmd.com/read/29456564/role-of-granulocyte-colony-stimulating-factor-in-human-reproduction
#2
REVIEW
Maryam Eftekhar, Elham Naghshineh, Parisa Khani
As new research reveals, granulocyte colony-stimulating factor (G-CSF) plays an effective role in pregnancy success, considering that it not only affects the embryo implantation and ovarian function but also it promotes endometrial thickening and improves the pathophysiology of endometriosis, which all fundamentally lead to reducing pregnancy loss. In this review, we focus on the role of G-CSF in human reproduction. We summarized its role in ovulation, luteinized unruptured follicle syndrome, poor responders, improving repeated in vitro fertilization failure, endometrial receptivity and treatment of thin endometrium, and recurrent spontaneous abortion...
2018: Journal of Research in Medical Sciences: the Official Journal of Isfahan University of Medical Sciences
https://www.readbyqxmd.com/read/29331829/additional-small-dose-of-prostaglandin-f2%C3%AE-at-timed-artificial-insemination-failed-to-improve-pregnancy-risk-of-lactating-dairy-cows
#3
J A Sauls, B E Voelz, L G D Mendonça, J S Stevenson
Two experiments were performed to test the hypothesis that administering PGF2α concurrent with timed artificial insemination (AI) in lactating dairy cows would enhance pregnancy per AI (P/AI). In experiment 1, lactating Holstein cows (n = 289) in one herd were enrolled after a non-pregnancy diagnosis (30-36 d after AI) to synchronize subsequent ovulation before AI. Cows were assigned randomly to receive (im) 10 mg of PGF2α concurrent with timed AI (Day 0; treatment) or no injection (control). Blood samples were collected on Days -3, 0, and 13 to determine serum concentrations of progesterone...
January 3, 2018: Theriogenology
https://www.readbyqxmd.com/read/29242273/rbpj-mediates-uterine-repair-in-the-mouse-and-is-reduced-in-women-with-recurrent-pregnancy-loss
#4
Michael R Strug, Ren-Wei Su, Tae Hoon Kim, Alessandro Mauriello, Carlo Ticconi, Bruce A Lessey, Steven L Young, Jeong Mook Lim, Jae-Wook Jeong, Asgerally T Fazleabas
Unexplained recurrent pregnancy loss (uRPL) is associated with repeated embryo loss and endometrial repair with elevated endometrial expression of inflammatory cytokines, including IFN-γ. Notch signaling through its transcription factor recombination signal binding protein Jκ (RBPJ) regulates mechanisms including the immune response and repair after tissue injury. Initially, null mutation of RBPJ in the mouse uterus (Pgrcre/+Rbpjf/f ; Rbpj c-KO) results in subfertility, but we have found that these mice become infertile after pregnancy as a result of dysfunctional postpartum uterine repair, including delayed endometrial epithelial and myometrial regeneration...
December 14, 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/29229837/early-endosome-as-a-pathogenic-target-for-antiphosphatidylethanolamine-antibodies
#5
Songwang Hou, Heike Fölsch, Ke Ke, Joan Cook Mills, Rosalind Ramsey-Goldman, Ming Zhao
Phosphatidylethanolamine (PE) is a major phospholipid species with important roles in membrane trafficking and reorganization. Accumulating clinical data indicate that the presence of circulating antibodies against PE is positively correlated with the symptoms of antiphospholipid syndromes (APS), including thrombosis and repeated pregnancy loss. However, PE is generally sequestered inside a normal resting cell, and the mechanism by which circulating anti-PE antibodies access cellular PE remains unknown. The studies presented here were conducted with synthetic PE-binding agents, plasma samples from patients with anti-PE autoimmunity, and purified anti-PE antibodies...
December 26, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29184865/etiological-evaluation-of-repeated-biochemical-pregnancy-in-infertile-couples-who-have-undergone-in-vitro-fertilization
#6
Hyun-Mi Lee, Hwa Jeong Lee, Kwang Moon Yang, Sun Hwa Cha, Hyun Kyong Ahn, Young Joo Kim
Objective: This study aims to investigate whether there are any notable etiologies for repeated biochemical pregnancy (RBP) and, if so, to compare those etiologies associated with repeated spontaneous abortion in infertile couples who have undergone in vitro fertilization (IVF). Methods: Forty-four infertile couples who underwent IVF and experienced RBP were included in this study. RBP was defined as more than 2 early pregnancy losses that occurred before the detection of a gestational sac, with ectopic pregnancies specifically excluded by serial serum beta human chorionic gonadotropin evaluation...
November 2017: Obstetrics & Gynecology Science
https://www.readbyqxmd.com/read/29142651/prevention-of-insulin-resistance-by-dietary-intervention-among-pregnant-mothers-a-randomized-controlled-trial
#7
Masoomeh Goodarzi-Khoigani, Seyed Saeed Mazloomy Mahmoodabad, Mohammad Hossein Baghiani Moghadam, Azadeh Nadjarzadeh, Farahnaz Mardanian, Hossein Fallahzadeh, Azam Dadkhah-Tirani
Background: Chronic insulin resistance (IR) is a basic part of the pathophysiology of gestational diabetes mellitus. Nutrition significantly impacts IR and weight loss reduces insulin levels, whereas weight gain increases the concentrations. Therefore, we surveyed the effect of nutrition intervention on IR in pregnant women and whether this effect is irrespective of weight gaining in accordance with Institute of Medicine limits. Methods: This prospective, randomized clinical trial was carried out among 150 primiparous pregnant mothers in fifteen health centers, five hospitals, and 15 private obstetrical offices in Isfahan...
2017: International Journal of Preventive Medicine
https://www.readbyqxmd.com/read/29121417/transabdominal-cerclage-tac-for-patients-with-ultra-short-uterine-cervix-after-uterine-cervix-surgery-and-its-impact-on-pregnancy
#8
Shinichi Ishioka, Miseon Kim, Yuko Mizugaki, Saori Kon, Kyoko Isoyama, Masahito Mizuuchi, Miyuki Morishita, Tsuyoshi Baba, Takao Sekiya, Tsuyoshi Saito
AIM: Patients with an ultra-short uterine cervix as a result of large conization, repeated conization or radical trachelectomy (RT), are at high risk of preterm premature rupture of the membrane, which leads to preterm birth. We have commenced performing transabdominal cerclage (TAC) of the uterine cervix for these patients. In this study, we examined the safety of TAC and its impact on pregnancy. METHODS: We have performed TAC in 11 patients before pregnancy: in six after large cervical operations, such as repeated conization; and in five for difficulties with cervical cerclage after RT...
November 9, 2017: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/29112656/interpregnancy-interval-after-pregnancy-loss-and-risk-of-repeat-miscarriage
#9
Alexandra C Sundermann, Katherine E Hartmann, Sarah H Jones, Eric S Torstenson, Digna R Velez Edwards
OBJECTIVE: To assess whether interpregnancy interval length after a pregnancy loss is associated with risk of repeat miscarriage. METHODS: This analysis includes pregnant women participating in the Right From the Start (2000-2012) community-based prospective cohort study whose most recent pregnancy before enrollment ended in miscarriage. Interpregnancy interval was defined as the time between a prior miscarriage and the last menstrual period of the study pregnancy...
December 2017: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29102427/effect-of-repeated-cryopreservation-on-human-embryo-developmental-potential
#10
Xiaoying Zheng, Yuan Chen, Jie Yan, Yuqi Wu, Xinjie Zhuang, Shengli Lin, Jinliang Zhu, Ying Lian, Jie Qiao, Ping Liu
Repeated cryopreservation of surplus embryos from frozen-thawed cycles should occasionally be considered. The purpose of this retrospective cohort study was to evaluate the pregnancy and perinatal outcome of repeated cryopreservation by vitrification of human blastocysts derived from slowly frozen-thawed day 3 embryos. In total, 571 vitrified-warmed blastocyst transfer cycles were investigated. The vitrified-warmed blastocysts were derived from slowly frozen-thawed cleavage embryos (twice-cryopreserved group) or fresh embryos (control group) cultured to the blastocyst stage...
August 24, 2017: Reproductive Biomedicine Online
https://www.readbyqxmd.com/read/29095179/barriers-to-research-recruitment-of-women-experiencing-a-pregnancy-loss-in-the-emergency-department
#11
Brittany E Punches, Kimberly D Johnson, Shauna P Acquavita, Dianne M Felblinger, Gordon L Gillespie
Women often come to the emergency department (ED) with signs and symptoms suggesting an early pregnancy loss; yet, little is known about their experience and how it relates to future outcomes. To improve patient outcomes and experiences of women seeking care for a pregnancy loss, research is required. However, recruitment of participants experiencing an event such as a pregnancy loss is challenging. The purpose of this article is to discuss the application of an electronic medical record (EMR)-based participant screening tool recruiting women seeking care for a pregnancy loss in the ED...
October 2017: Advanced Emergency Nursing Journal
https://www.readbyqxmd.com/read/29058511/pregnancy-in-a-non-communicating-rudimentary-horn-a-cause-of-failed-medical-and-surgical-management-of-second-trimester-pregnancy-loss
#12
Diaa Abd El-Halim, Haitham A Torky
OBJECTIVES: We present the management of a case of failed medical and surgical management of second trimester pregnancy loss due to pregnancy in a non-communicating rudimentary horn. CASE: A 16-week intrauterine fetal death singleton pregnancy was referred to us after failed medical and surgical termination of pregnancy. Ultrasound confirmed the diagnosis and showed minimal blood clots and fluid in the pouch of Douglas. Laparoscopy showed a soft, enlarged right uterine horn not communicating with the cervix and containing the pregnancy, and a left uterine horn communicating with the cervix and showing a posterior wall perforation...
October 23, 2017: European Journal of Contraception & Reproductive Health Care
https://www.readbyqxmd.com/read/29043704/accuracy-of-two-dimensional-transvaginal-sonography-and-office-hysteroscopy-for-detection-of-uterine-abnormalities-in-patients-with-repeated-implantation-failures-or-recurrent-pregnancy-loss
#13
Marzieh Shiva, Firouzeh Ahmadi, Arezoo Arabipoor, Mansoureh Oromiehchi, Mohammad Chehrazi
Background: We sought to compare diagnostic values of two-dimensional transvaginal sonography (2D TVS) and office hysteroscopy (OH) for evaluation of endometrial pathologies in cases with repeated implantation failure (RIF) or recurrent pregnancy loss (RPL). MATERIALS AND METHODS: This prospective study was performed at Royan Institute from December 2013 to January 2015. TVS was performed before hysteroscopy as part of the routine diagnostic work-up in 789 patients with RIF or RPL...
January 2018: International Journal of Fertility & Sterility
https://www.readbyqxmd.com/read/28985033/associations-of-maternal-weight-status-before-during-and-after-pregnancy-with-inflammatory-markers-in-breast-milk
#14
Kara M Whitaker, Regina C Marino, Jacob L Haapala, Laurie Foster, Katy D Smith, April M Teague, David R Jacobs, Patricia L Fontaine, Patricia M McGovern, Tonya C Schoenfuss, Lisa Harnack, David A Fields, Ellen W Demerath
OBJECTIVE: The goal of this study was to examine the associations of maternal weight status before, during, and after pregnancy with breast milk C-reactive protein (CRP) and interleukin 6 (IL-6), two bioactive markers of inflammation, measured at 1 and 3 months post partum. METHODS: Participants were 134 exclusively breastfeeding mother-infant dyads taking part in the Mothers and Infants Linked for Health (MILK) study, who provided breast milk samples. Pre-pregnancy body mass index (BMI) and gestational weight gain (GWG) were assessed by chart abstraction; postpartum weight loss was measured at the 1- and 3-month study visits...
October 6, 2017: Obesity
https://www.readbyqxmd.com/read/28955201/fragile-x-associated-diminished-ovarian-reserve-and-primary-ovarian-insufficiency-from-molecular-mechanisms-to-clinical-manifestations
#15
REVIEW
Limor Man, Jovana Lekovich, Zev Rosenwaks, Jeannine Gerhardt
Fragile X syndrome (FXS), is caused by a loss-of-function mutation in the FMR1 gene located on the X-chromosome, which leads to the most common cause of inherited intellectual disability in males and the leading single-gene defect associated with autism. A full mutation (FM) is represented by more than 200 CGG repeats within the FMR1 gene, resulting in FXS. A FM is inherited from women carrying a FM or a premutation (PM; 55-200 CGG repeats) allele. PM is associated with phenotypes distinct from those associated with FM...
2017: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/28934391/homozygous-kidins220-loss-of-function-variants-in-fetuses-with-cerebral-ventriculomegaly-and-limb-contractures
#16
I-L Mero, H H Mørk, Y Sheng, A Blomhoff, G L Opheim, Aa Erichsen, M D Vigeland, K K Selmer
Heterozygous mutations in KIDINS220 were recently suggested a cause of spastic paraplegia, intellectual disability, nystagmus and obesity. All patients carried terminal nonsense de novo mutations that seemed to escape nonsense-mediated mRNA decay. The mechanism for pathogenicity is yet unexplained, as it seems that heterozygous loss-of-function variants of KIDINS220 are generally well tolerated. We present a consanguineous couple who experienced four pregnancy terminations due to repeated findings in the fetuses comprising enlarged cerebral ventricles and limb contractures...
October 1, 2017: Human Molecular Genetics
https://www.readbyqxmd.com/read/28934068/upper-limb-hemimelia-in-a-twin-pregnancy-which-was-obtained-by-an-icsi-and-pgd-in-a-woman-with-mosaic-turner-s-syndrome-and-the-prognosis
#17
Ahter Tanay Tayyar, Ahmet Tayyar, Ahmet Eser, Çetin Kılıçcı, İlter Yenidede, Selçuk Selçuk
Turner's syndrome (TS) is depicted as a total or partial absence of X chromosome, and occurs in approximately 1/2200 of live born females. Generally, mosaic patients are diagnosed following karyotype analysis due to recurrent pregnancy loss, repeated in vitro fertilization (IVF) failure, and a history of malformed babies. The purpose of this case report is to show that even a selection of normal karyotype embryos can result in abnormalities for those with mosaic TS. A 32-year old patient who underwent IVF after ICSI-PGD, and was diagnosed with 45X/46XX karyotype...
October 2, 2017: Organogenesis
https://www.readbyqxmd.com/read/28911008/maternal-dietary-l-arginine-and-adverse-birth-outcomes-in-dar-es-salaam-tanzania
#18
Anne Marie Darling, Chloe R McDonald, Willy S Urassa, Kevin C Kain, Ramadhani S Mwiru, Wafaie W Fawzi
The amino acid arginine is a physiological precursor to nitric oxide, which is a key mediator of embryonic survival, fetal growth, and pregnancy maintenance. We evaluated the association between consumption of the amino acid arginine and the rate of adverse birth outcomes using data from a double-blind, randomized, placebo-controlled micronutrient supplementation trial among pregnant women in Dar es Salaam, Tanzania (2001-2004). Dietary intakes of arginine were assessed using repeated 24-hour recalls that were administered throughout pregnancy...
September 1, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/28880461/grief-reactions-of-couples-to-perinatal-loss-a-one-year-prospective-follow-up
#19
Ying-Fen Tseng, Hsiu-Rong Cheng, Yu-Ping Chen, Shu-Fei Yang, Pi-Tzu Cheng
AIMS AND OBJECTIVES: To explore couples' perceptions of the effects of perinatal loss on their marital relationship, social support and grief 1 year postloss, and analyse what factors changed the severity of their grief. BACKGROUND: Perinatal losses are traumatic events in the lives of families and can have serious long-term consequences for the psychological health of parents and any subsequent children. DESIGN: A prospective follow-up study...
September 7, 2017: Journal of Clinical Nursing
https://www.readbyqxmd.com/read/28820406/-results-of-preparation-and-implementation-of-ivf-program-in-patients-with-thrombophilia-and-history-of-failed-ivf
#20
G Abrahamyan
The problem of infertility and reproductive losses maintains its urgency, as well as medical and social significance. Frequency of infertility in overall population, according to the data from different authors, varies from 9 to 18 per cent. Methods of aided reproductive technologies (ART) opened a new era in the field of correction of infertile marriage. As a result, more and more couples choose to solve this problem by means of aided reproductive technologies (ART): in-vitro fertilization (IVF) and embryo transfer (ET)...
July 2017: Georgian Medical News
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