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Repeated pregnancy losses

Brindha Arumugam, Chandra R Samuel, Santhiya Sathiyavedu Thyagarajan
Spontaneous abortion or loss of fetus prior to 20 weeks of gestation is observed in 15-20% of clinically recognized pregnancies. Recurrent Miscarriage (RM) is defined as three or more consecutive pregnancy losses and it affects 1-2% of women. Parental chromosomal rearrangements account for 2-5% of RM. This report describes two couples with a clinical history of RM who were subjected to conventional cytogenetic analysis to ascertain the chromosomal aetiology. Analysis of GTG-banded metaphases obtained from cultured lymphocytes at approximately 500-band resolution revealed balanced translocation in the female spouses as 46,XX,t(8;11)(p11...
December 2016: Journal of Clinical and Diagnostic Research: JCDR
Jessica Cristina Gimenes, Carolina Ferreira Nicoletti, Marcela Augusta de Souza Pinhel, Bruno Affonso Parenti de Oliveira, Wilson Salgado Júnior, Júlio Sérgio Marchini, Carla Barbosa Nonino
INTRODUCTION: Although pregnancy after bariatric surgery is related to risk reduction, nutritional complications may occur. This study aimed to evaluate nutritional and biochemical indicators of women who became pregnant after Roux en Y gastric bypass (RYGB). MATERIALS AND METHODS: We carried out a retrospective study with women who became pregnant after RYGB. We evaluated anthropometric, biochemical, and dietary intake indicators in the preoperative period and before, during, and after pregnancy by analysis of medical records...
January 19, 2017: Obesity Surgery
Sandrine Chamayou, Maria Sicali, Carmelita Alecci, Carmen Ragolia, Annalisa Liprino, Daniela Nibali, Giorgia Storaci, Antonietta Cardea, Antonino Guglielmino
PURPOSE: In a preimplantation genetic diagnosis for aneuploidy (PGD-A) program, the more embryos available for biopsy, consequently increases the chances of obtaining euploid embryos to transfer. The aim was to increase the number of viable euploid blastocysts in patients undergoing PGD-A using fresh oocytes together with previously accumulated vitrified oocytes. METHODS: Sixty-nine patients with normal ovarian reserve underwent PGD-A for repeated implantation failure or recurrent pregnancy loss indication...
January 9, 2017: Journal of Assisted Reproduction and Genetics
Rinat Gabbay-Benziv, Amir Dolev, Ron Bardin, Israel Meizner, Benjamin Fisch, Avi Ben-Haroush
OBJECTIVE: To evaluate the association between small crown-rump length (CRL) and fetal loss ≤22 weeks in IVF pregnancies. METHODS: A retrospective analysis of prospectively collected data at a university-affiliated medical center. All singleton IVF pregnancies within a 5-year period, with a live embryo on first-trimester ultrasound and verified pregnancy outcome were included. Rates of fetal loss ≤22 weeks were compared between pregnancies with a CRL ≤tenth percentile and above the tenth percentile of our population...
January 7, 2017: Archives of Gynecology and Obstetrics
Kamarul B Mustafa, Kevin N Keane, Nikita L Walz, Katarina I Mitrovic, Peter M Hinchliffe, John L Yovich
This seven-year retrospective study analysed the live birth rate (LBR) for women undergoing IVF treatment with various antral follicle counts (AFC). The LBR decreased with lower AFC ratings, and in 290 treatment cycles for women in the poorest AFC category, ≤4 follicles (group E), the LBR was the lowest at 10.7%. The pregnancy loss rate (PLR) significantly increased with poorer AFC categories, from 21.8% in AFC group A (≥20 follicles), to 54.4% in AFC group E (p<0.0001). This trend was repeated with advancing age, from 21...
December 7, 2016: Reproductive Biology
Sandra Gijzen, Monique P L'Hoir, Magda M Boere-Boonekamp, Ariana Need
BACKGROUND: A child's death is an enormous tragedy for both the parents and other family members. Support for the parents can be important in helping them to cope with the loss of their child. In the Netherlands little is known about parents' experiences of the support they receive after the death of their child. The purpose of this study is to determine what support parents in the Netherlands receive after the death of their child and whether the type of care they receive meets their needs...
December 7, 2016: BMC Pediatrics
F F Coelho, F K Marques, M S Gonçalves, V C O Almeida, E C C Mateo, A C S Ferreira
Approximately 10-15% of all pregnancies end in spontaneous abortions. Many factors can lead to embryonic loss; however, it has been well established that over 50% of all miscarriages result from chromosomal abnormalities, primarily aneuploidies (>96%). Identifying the cause of miscarriage can significantly reduce the psychological stress in women, and enable better genetic counseling for a future pregnancy. Quantitative fluorescent polymerase chain reaction (QF-PCR) has been previously used in the study of chromosomal abnormalities...
September 23, 2016: Genetics and Molecular Research: GMR
Lin Foo, Carmel McEniery, Ian Wilkinson, Christoph Lees
INTRODUCTION: Inadequate cardiovascular adaptation to pregnancy has been postulated as a potential cause or consequence of early pregnancy loss. We sought to investigate pre- and early pregnancy cardiovascular function in women with a viable pregnancy beyond the first trimester, and those suffering a first trimester pregnancy loss. METHODS: We recruited healthy women trying for pregnancy without assisted reproductive technology into an observational pre-conception study, and recorded pregnancy loss as a clinical endpoint...
August 2016: Journal of Maternal-fetal & Neonatal Medicine
Helena Hognert, Helena Kopp Kallner, Sharon Cameron, Christina Nyrelli, Izabella Jawad, Rebecca Heller, Annette Aronsson, Ingela Lindh, Lina Benson, Kristina Gemzell-Danielsson
STUDY QUESTION: Does a progestin releasing subdermal contraceptive implant affect the efficacy of medical abortion if inserted at the same visit as the progesterone receptor modulator, mifepristone, at medical abortion? SUMMARY ANSWER: A etonogestrel releasing subdermal implant inserted on the day of mifepristone did not impair the efficacy of the medical abortion compared with routine insertion at 2-4 weeks after the abortion. WHAT IS ALREADY KNOWN: The etonogestrel releasing subdermal implant is one of the most effective long acting reversible contraceptive methods...
November 2016: Human Reproduction
J M Puente, A Fabris, J Patel, A Patel, M Cerrillo, A Requena, J A Garcia-Velasco
BACKGROUND: Adenomyosis is linked to infertility, but the mechanisms behind this relationship are not clearly established. Similarly, the impact of adenomyosis on ART outcome is not fully understood. Our main objective was to use ultrasound imaging to investigate adenomyosis prevalence and severity in a population of infertile women, as well as specifically among women experiencing recurrent miscarriages (RM) or repeated implantation failure (RIF) in ART. METHODS: Cross-sectional study conducted in 1015 patients undergoing ART from January 2009 to December 2013 and referred for 3D ultrasound to complete study prior to initiating an ART cycle, or after ≥3 IVF failures or ≥2 miscarriages at diagnostic imaging unit at university-affiliated private IVF unit...
September 20, 2016: Reproductive Biology and Endocrinology: RB&E
Nasreen Akhtar, Weiping Li, Aleksander Mironov, Charles H Streuli
An important feature of the mammary gland is its ability to undergo repeated morphological changes during each reproductive cycle with profound tissue expansion in pregnancy and regression in involution. However, the mechanisms that determine the tissue's cyclic regenerative capacity remain elusive. We have now discovered that Cre-Lox ablation of Rac1 in mammary epithelia causes gross enlargement of the epithelial tree and defective alveolar regeneration in a second pregnancy. Architectural defects arise because loss of Rac1 disrupts clearance in involution following the first lactation...
September 12, 2016: Developmental Cell
I Dedes, L Schäffer, R Zimmermann, T Burkhardt, C Haslinger
AIM: To evaluate the outcome of a cesarean myomectomy (CM) versus a cesarean delivery (CD) alone in women with uterine myomas and the risk factors for adverse outcomes. METHODS: A retrospective cohort study of all women undergoing CDs with uterine leiomyomatas and singleton pregnancies was performed. Patients with known risk factors for hemorrhage were excluded. Measured adverse outcome parameters included estimated blood loss, drop in hemoglobin levels (pre/postoperatively), operation time, and the use of additional uterotonics...
August 24, 2016: Archives of Gynecology and Obstetrics
Joanne Kwak-Kim, Annie Skariah, Li Wu, Dinorah Salazar, Nayoung Sung, Kuniaki Ota
Women with recurrent pregnancy losses (RPL) and repeated implantation failures (RIF) have auto- and cellular immune abnormalities. Approximately, 20% of women with RPL have autoimmune abnormalities, particularly antiphospholipid antibodies (APA). In addition, these women have a higher prevalence of antinuclear antibody, anti-thyroperoxidase and anti-thyroglobulin antibodies, and other non-organ-specific autoantibodies. In women with RPL, the presence of autoimmunity is often associated with cellular immune abnormalities, such as increased NK cell levels and Th1/Th2 cell ratios...
October 2016: Autoimmunity Reviews
Nobuaki Ozawa, Haruhiko Sago, Kentaro Matsuoka, Tetsuo Maruyama, Ohsuke Migita, Yoshinori Aizu, Johji Inazawa
BACKGROUND: Cytogenetic analysis of products of conception (POC) is essential for the management of recurrent pregnancy loss (RPL), but the currently-performed G-banding method is not necessarily applicable to spontaneously discharged POC because of poor quality for culture. We analyzed the karyotypes of 15 spontaneously discharged POC by array-based comparative genomic hybridization (array-CGH). RESULTS: All specimens were successfully analyzed and 10 cases had abnormal results: gain in copy number (n = 7) and loss in copy number (n = 3)...
2016: SpringerPlus
Satinder Verma, Adarsh Choudhary, Shivi Maini, K Ravikanth
OBJECTIVE: To evaluate the efficacy of herbal intrauterine infusion Uterofix liquid in the treatment of various reproductive disorders in cows. MATERIALS AND METHODS: Based on symptoms of endometritis, anestrous, metritis, and repeat breeders, 28 cows were selected to study the efficacy of herbal intrauterine infusion Uterofix liquid (M/S Ayurvet Limited) in uterine infections study. Group T0 (n = 8) cows served as control group, no treatment was given to this group, Group T1 (n = 5) repeat breeder cows, Group T2 (n = 5) endometritis effected cows, Group T3 (n = 5) anoestrus cows, and Group T4 (n = 5) metritis suffered cows were treated with Uterofix liquid (25 ml as intrauterine infusion once a day for 3-5 days)...
July 2016: Pharmacognosy Research
Carmen Messerlian, Blair J Wylie, Lidia Mínguez-Alarcón, Paige L Williams, Jennifer B Ford, Irene C Souter, Antonia M Calafat, Russ Hauser
BACKGROUND: Animal studies demonstrate that several phthalates are embryofetotoxic and are associated with increased pregnancy loss and malformations. Results from human studies on phthalates and pregnancy loss are inconsistent. METHODS: We examined pregnancy loss prospectively in relation to urinary phthalate metabolite concentrations among women undergoing medically assisted reproduction. We used data from 256 women conceiving 303 pregnancies recruited between 2004 and 2012 from the Massachusetts General Hospital Fertility Center...
November 2016: Epidemiology
Ignacio Maeso, Thomas L Dunwell, Chris D R Wyatt, Ferdinand Marlétaz, Borbála Vető, Juan A Bernal, Shan Quah, Manuel Irimia, Peter W H Holland
BACKGROUND: A central goal of evolutionary biology is to link genomic change to phenotypic evolution. The origin of new transcription factors is a special case of genomic evolution since it brings opportunities for novel regulatory interactions and potentially the emergence of new biological properties. RESULTS: We demonstrate that a group of four homeobox gene families (Argfx, Leutx, Dprx, Tprx), plus a gene newly described here (Pargfx), arose by tandem gene duplication from the retinal-expressed Crx gene, followed by asymmetric sequence evolution...
2016: BMC Biology
Yasminur G Turdybekova, Raushan S Dosmagambetova, Symbat U Zhanabayeva, Gena V Bublik, Alik B Kubayev, Zhanbolat G Ibraibekov, Irina L Kopobayeva, Berikbay Zh Kultanov
In order to assess women's reproductive health in the Kyzylorda region (the Aral Sea) of Kazakhstan, 1406 women were involved in an integrated clinical-functional and laboratory examination, given regional and environmental ecological factors. The high level of endocrine gynecological pathology is indicated in the examined women. In both examined zones, there is a late menarche over 16 years old, which is 39%. It is indicated a trend towards younger age of menopause onset. Inflammatory diseases of the female genital organs affect a third of the examined women...
September 15, 2015: Open Access Macedonian Journal of Medical Sciences
M Bakker, E Birnie, P Robles de Medina, Krystyna Sollie, E Pajkrt, C M Bilardo
OBJECTIVE: To identify maternal-, operator-, and procedure-related variables affecting the procedure related pregnancy loss after transcervical (tc) and transabdominal (ta) chorion villus sampling (cvs) and amniocentesis (ac). To estimate the spontaneous and procedure-related fetal losses in comparable subgroups of women. METHODS: A retrospective cohort study conducted at the University Medical Centre Groningen and the Academic Medical Centre Amsterdam, the Netherlands...
June 3, 2016: Ultrasound in Obstetrics & Gynecology
Sihao Zhao, Neil J Sebire, Baljeet Kaur, Michael J Seckl, Rosemary A Fisher
OBJECTIVE: To investigate a large series of placental site trophoblastic tumours (PSTT) and epithelioid trophoblastic tumours (ETT) and determine the relationship between their development and the type and sex of both the immediately antecedent and causative pregnancies. METHODS: The antecedent pregnancy was determined from patient records in 92 cases with a confirmed diagnosis of PSTT, ETT or mixed PSTT/ETT. In a subset of 57 cases, type and sex of the causative pregnancy was established by molecular genotyping of tumour tissue microdissected from formalin-fixed, paraffin-embedded blocks...
September 2016: Gynecologic Oncology
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