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Polycystic ovarian disease

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https://www.readbyqxmd.com/read/28711970/does-a-male-polycystic-ovarian-syndrome-equivalent-exist
#1
REVIEW
R Cannarella, R A Condorelli, L M Mongioì, S La Vignera, A E Calogero
The occurrence of a genetic background in the etiology of polycystic ovarian syndrome (PCOS) represents the rational basis to postulate the existence of a male PCOS equivalent. Hormonal and metabolic abnormalities have been described in male relatives of women with PCOS. These males also have a higher prevalence of early onset (<35 years) androgenetic alopecia (AGA). Hence, this feature has been proposed as a clinical sign of the male PCOS equivalent. Clinical evidence has shown that men with early onset AGA have hormonal and metabolic abnormalities...
July 15, 2017: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/28694181/allopregnanolone-involvement-in-feeding-regulation-overeating-and-obesity
#2
E Holmberg, J Sjöstedt, E Malinina, M Johansson, S Turkmen, G Ragagnin, A Lundqvist, M Löfgren, L Jaukkuri, M Bixo, T Bäckström
Obesity is strongly associated with ill health, primarily caused by consumption of excessive calories, and promoted (inter alia) by gamma-amino-butyric-acid (GABA) stimulating food intake by activating GABAA receptors (primarily with α3 and α2 subunits) in the hypothalamic arcuate nucleus and paraventricular nucleus. Allopregnanolone is a potent positive GABAA receptor modulating steroid (GAMS). As reviewed here, elevated allopregnanolone levels are associated with increases in food intake, preferences for energy-rich food, and obesity in humans and other mammals...
July 8, 2017: Frontiers in Neuroendocrinology
https://www.readbyqxmd.com/read/28683237/late-night-salivary-cortisol-is-unaltered-in-patients-with-polycystic-ovarian-syndrome-pcos-irrespective-of-disease-phenotype-and-in-obese-women-irrespective-of-the-presence-of-pcos
#3
Hande Mefkure Ozkaya, Fatma Ela Keskin, Abdullah Tuten, Ebru Korkmaz, Hulya Zeynep Oktay, Pinar Kadioglu
OBJECTIVE: To determine cut-off values of late-night salivary cortisol (LNSC) using an electrochemiluminescent immunoassay (ECLIA) and to investigate whether the diagnostic performance of the assay was influenced by the presence of obesity or polycystic ovary syndrome (PCOS). METHODS: A total of 124 subjects comprising 25 patients with Cushing's syndrome (CS), 44 with PCOS (22 nonobese and 22 obese), 21 with constitutional obesity (CO), and 34 healthy subjects (HS) were included in the study...
July 6, 2017: Endocrine Practice
https://www.readbyqxmd.com/read/28656689/multiple-reaction-monitoring-mrm-profiling-for-biomarker-discovery-applied-to-human-polycystic-ovarian-syndrome
#4
Fernanda B Cordeiro, Christina R Ferreira, Tiago Jose P Sobreira, Karen E Yannell, Alan K Jarmusch, Agnaldo P Cedenho, Edson G Lo Turco, R Graham Cooks
RATIONALE: We describe multiple reaction monitoring (MRM)-profiling, which provides accelerated discovery of discriminating molecular features, and its application to human polycystic ovary syndrome (PCOS) diagnosis. The discovery phase of the MRM-profiling seeks molecular features based on some prior knowledge of the chemical functional groups likely to be present in the sample. It does this through use of a limited number of pre-chosen and chemically specific neutral loss and/or precursor ion MS/MS scans...
June 28, 2017: Rapid Communications in Mass Spectrometry: RCM
https://www.readbyqxmd.com/read/28645304/validation-of-an-automated-technique-for-ovarian-cortex-dissociation-isolation-of-viable-ovarian-cells-and-their-qualification-by-multicolor-flow-cytometry
#5
Tristan Zver, Elodie Mouloungui, Aurélie Berdin, Christophe Roux, Clotilde Amiot
BACKGROUND: Ovarian tissue cryopreservation is a technique for fertility preservation addressed to prepubertal girls or to patients for whom no ovarian stimulation is possible before initiation of gonadotoxic treatments. Autotransplantation of frozen-thawed ovarian tissue is the only available option for reuse but presents some limitations: ischemic tissue damages post-transplant and reintroduction of malignant cells in cases of cancer. It is therefore essential to qualify ovarian tissue before autograft on a functional and oncological point of view...
June 23, 2017: Journal of Ovarian Research
https://www.readbyqxmd.com/read/28643088/potential-therapeutic-applications-of-human-anti-m%C3%A3-llerian-hormone-amh-analogues-in-reproductive-medicine
#6
REVIEW
Vitaly A Kushnir, David B Seifer, David H Barad, Aritro Sen, Norbert Gleicher
Members of the transforming growth factor-beta (TGF-beta) superfamily are key regulators of various physiological processes. Anti-Müllerian hormone (AMH) which is also commonly known as Müllerian-inhibiting substance (MIS) is a member of the TGF-beta superfamily and an important regulator of reproductive organ differentiation and ovarian follicular development. While AMH has been used for diagnostic purposes as a biomarker for over 15 years, new potential therapeutic applications of recombinant human AMH analogues are now emerging as pharmacologic agents in reproductive medicine...
June 22, 2017: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/28643028/polycystic-ovary-syndrome-adipose-tissue-and-metabolic-syndrome
#7
REVIEW
Alessandro P Delitala, Giampiero Capobianco, Giuseppe Delitala, Pier Luigi Cherchi, Salvatore Dessole
PURPOSE: Polycystic ovary syndrome (PCOS) is the most common endocrine disorder that affects women of reproductive age and is characterized by ovulatory dysfunction and/or androgen excess or polycystic ovaries. Women with PCOS present a number of systemic symptoms in addition to those related to the reproductive system. It has been associated with functional derangements in adipose tissue, metabolic syndrome, type 2 diabetes, and an increased risk of cardiovascular disease (CVD). METHODS: A detailed literature search on Pubmed was done for articles about PCOS, adipokines, insulin resistance, and metabolic syndrome...
June 22, 2017: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/28620546/ovarian-morphology-is-associated-with-insulin-resistance-in-women-with-polycystic-ovary-syndrome-a-cross-sectional-study
#8
Sara Pittenger Reid, Chia-Ning Kao, Lauri Pasch, Kanade Shinkai, Marcelle I Cedars, Heather G Huddleston
BACKGROUND: Polycystic ovary syndrome (PCOS) is a very common disorder well known to be associated with insulin resistance and metabolic disease. Insulin resistance is likely involved in the promotion of the PCOS reproductive phenotype and may mediate some of the ovarian morphology seen in the disorder. The phenotype of each individual woman with PCOS can vary widely as can her metabolic risk. METHODS: This is a cross-sectional study of patients seen in a multidisciplinary PCOS clinic at the University of California at San Francisco between 2006 and 2014...
2017: Fertility Research and Practice
https://www.readbyqxmd.com/read/28619690/metformin-the-aspirin-of-the-21st-century-its%C3%A2-role-in-gestational-diabetes-mellitus-prevention-of-preeclampsia-and-cancer-and%C3%A2-the-promotion-of-longevity
#9
REVIEW
Roberto Romero, Offer Erez, Maik Hüttemann, Eli Maymon, Bogdan Panaitescu, Agustin Conde-Agudelo, Percy Pacora, Bo Hyun Yoon, Lawrence I Grossman
Metformin is everywhere. Originally introduced in clinical practice as an antidiabetic agent, its role as a therapeutic agent is expanding to include treatment of prediabetes mellitus, gestational diabetes mellitus, and polycystic ovarian disease and, more recently, experimental studies and observations in randomized clinical trials suggest that metformin could have a place in the treatment or prevention of preeclampsia. This article provides a brief overview of the history of metformin in the treatment of diabetes mellitus, reviews the results of metaanalyses of metformin in gestational diabetes mellitus, and the treatment of obese non-diabetic pregnant women to prevent macrosomia...
June 12, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28608465/effect-of-bisphenol-a-on-reproductive-processes-a-review-of-in-vitro-in-vivo-and-epidemiological-studies
#10
REVIEW
Agnieszka Tomza-Marciniak, Paulina Stępkowska, Jarosław Kuba, Bogumiła Pilarczyk
As bisphenol A (BPA) is characterized by a pronounced influence on human hormonal regulation, particular attention has been aimed at understanding its role in reproductive processes in males and females, as well as on fetal development. Owing to the increasing number of alarming reports on the negative consequences of the presence of BPA in human surroundings, more and more studies are being undertaken to clarify the negative effects of BPA on human reproductive processes. The aim of this work was to collect and summarize data on the influence of BPA exposure on reproductive health...
June 13, 2017: Journal of Applied Toxicology: JAT
https://www.readbyqxmd.com/read/28599952/risk-of-developing-obstructive-sleep-apnea-among-women-with-polycystic-ovarian-syndrome-a-nationwide-longitudinal-follow-up-study
#11
Ting-Yang Lin, Pei-Yin Lin, Tung-Ping Su, Cheng-Ta Li, Wei-Chen Lin, Wen-Hang Chang, Tzeng-Ji Chen, Ya-Mei Bai, Mu-Hong Chen
BACKGROUND: Previous cross-sectional studies have suggested a comorbid relationship between polycystic ovarian syndrome (PCOS) and obstructive sleep apnea (OSA). However, the temporal association between these two distinct diseases has not yet been investigated. METHODS: Using the Taiwan National Health Insurance Research Database, 4595 women with PCOS and 4595 (1:1) age-/sex-matched controls were enrolled into the present study between 1998 and 2009, and followed to the end of 2011...
March 10, 2017: Sleep Medicine
https://www.readbyqxmd.com/read/28584836/effect-of-green-tea-on-metabolic-and-hormonal-aspect-of-polycystic-ovarian-syndrome-in-overweight-and-obese-women-suffering-from-polycystic-ovarian-syndrome-a-clinical-trial
#12
Hatav Gasemi Tehrani, Maryam Allahdadian, Farzane Zarre, Hanie Ranjbar, Fateme Allahdadian
BACKGROUND AND OBJECTIVE: Polycystic ovarian syndrome (PCOS) is the common cause of Oligo-ovulation. This syndrome causes long-term metabolic issues as well as increase the risk of diabetes type 2, hypertension, dyslipidemia, and cardiovascular disease. The current research aimed to study the effect of green tea on weight and hormonal changes of women suffering from PCOS. METHODS: This two group, double-blind, randomized clinical trial was conducted in Isfahan city...
2017: Journal of Education and Health Promotion
https://www.readbyqxmd.com/read/28551304/polycystic-ovary-syndrome-understanding-the-role-of-the-brain
#13
REVIEW
Aleisha M Moore, Rebecca E Campbell
Polycystic ovary syndrome (PCOS) is a prevalent endocrine disorder and the leading cause of anovulatory infertility. Characterised by hyperandrogenism, menstrual dysfunction and polycystic ovaries, PCOS is a broad-spectrum disorder unlikely to stem from a single common origin. Although commonly considered an ovarian disease, the brain is now a prime suspect in both the ontogeny and pathology of PCOS. We discuss here the neuroendocrine impairments present in PCOS that implicate involvement of the brain and review evidence gained from pre-clinical models of the syndrome about the specific brain circuitry involved...
July 2017: Frontiers in Neuroendocrinology
https://www.readbyqxmd.com/read/28543550/polycystic-ovary-morphology-is-associated-with-insulin-resistance-in-women-with-polycystic-ovary-syndrome
#14
So-Hyeon Hong, Yeon-Ah Sung, Young Sun Hong, Kyungah Jeong, Hyewon Chung, Hyejin Lee
BACKGROUND/OBJECTIVES: Polycystic ovary syndrome (PCOS) is a heterogeneous disorder characterised by chronic anovulation, hyperandrogenenism, polycystic ovary morphology (PCOM), and metabolic disturbances including insulin resistance and type 2 diabetes mellitus. Although insulin resistance could be associated with PCOM, recent studies have shown controversial results. The aim of this study was to determine the relationship between PCOM and insulin resistance. SUBJECTS/METHODS: This was a cross-sectional clinical study...
May 20, 2017: Clinical Endocrinology
https://www.readbyqxmd.com/read/28534980/a-proteomic-analysis-identifies-candidate-early-biomarkers-to-predict-ovarian-hyperstimulation-syndrome-in-polycystic-ovarian-syndrome-patients
#15
Lan Wu, Yazhou Sun, Jun Wan, Ting Luan, Qing Cheng, Yong Tan
Ovarian hyperstimulation syndrome (OHSS) is a potentially life‑threatening, iatrogenic complication that occurs during assisted reproduction. Polycystic ovarian syndrome (PCOS) significantly increases the risk of OHSS during controlled ovarian stimulation. Therefore, a more effective early prediction technique is required in PCOS patients. Quantitative proteomic analysis of serum proteins indicates the potential diagnostic value for disease. In the present study, the authors revealed the differentially expressed proteins in OHSS patients with PCOS as new diagnostic biomarkers...
July 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28529126/l-a-ratio-insulin-resistance-and-metabolic-risk-in-women-with-polycystic-ovarian-syndrome
#16
Vandana Gupta, Supriya Mishra, Sameeksha Mishra, Vani Gupta
BACKGROUND AND AIMS: The plasma leptin-adiponectin ratio (L:A) has been suggested as a one of the potentially independent predictor of metabolic risk and Insulin resistance in women with polycystic ovarian syndrome (PCOS). METHODS: This is a case-control study, total 439 female subjects, comprises in to two group 223 cases (PCOS) and 216 control (non-PCOS women) according to their clinical characteristics. Further both case and control group were sub-grouped in PCOS and non-PCOS with metabolic syndrome (wMetS) and without metabolic syndrome (woMetS) as per National Cholesterol Education Program Treatment Panel (NCEPATP) guidelines...
May 10, 2017: Diabetes & Metabolic Syndrome
https://www.readbyqxmd.com/read/28469096/protective-effects-of-curcumin-against-sodium-arsenite-induced-ovarian-oxidative-injury-in-a-mouse-model
#17
Xiao-Ning Wang, Chang-Jun Zhang, Hong-Lu Diao, Ying Zhang
BACKGROUND: Excessive reactive oxygen species (ROS) may lead to a number of reproductive diseases such as polycystic ovary syndrome. This study aimed to establish an animal model of ovarian oxidative stress and to assess the protective effect of curcumin against oxidative injury. METHODS: Ovarian oxidative stress was induced in female Kunming mice (n = 40) with intraperitoneal injection of 8 mg/kg sodium arsenite (As) once every other day for 16 days; meanwhile, they were, respectively, treated by intragastric administration of 0, 100, 150, or 200 mg/kg (n = 10/group) curcumin once per day for 21 days...
May 5, 2017: Chinese Medical Journal
https://www.readbyqxmd.com/read/28443200/epidemiology-of-ovarian-cancer-a-review
#18
Brett M Reid, Jennifer B Permuth, Thomas A Sellers
Ovarian cancer (OC) is the seventh most commonly diagnosed cancer among women in the world and the tenth most common in China. Epithelial OC is the most predominant pathologic subtype, with five major histotypes that differ in origination, pathogenesis, molecular alterations, risk factors, and prognosis. Genetic susceptibility is manifested by rare inherited mutations with high to moderate penetrance. Genome-wide association studies have additionally identified 29 common susceptibility alleles for OC, including 14 subtype-specific alleles...
February 2017: Cancer Biology & Medicine
https://www.readbyqxmd.com/read/28432106/prohibitin-induced-obesity-leads-to-anovulation-and-polycystic-ovary-in-mice
#19
Sudharsana Rao Ande, Khanh Hoa Nguyen, Yang Xin Zi Xu, Suresh Mishra
Polycystic ovary syndrome (PCOS) is a prevalent endocrine disorder and the most common cause of female infertility. However, its etiology and underlying mechanisms remain unclear. Here we report that a transgenic obese mouse (Mito-Ob) developed by overexpressing prohibitin in adipocytes develops polycystic ovaries. Initially, the female Mito-Ob mice were equally fertile to their wild-type littermates. The Mito-Ob mice began to gain weight after puberty, became significantly obese between 3-6 months of age, and ∼25% of them had become infertile by 9 months of age...
June 15, 2017: Biology Open
https://www.readbyqxmd.com/read/28428941/cardiovascular-risk-may-be-increased-in-women-with-unexplained-infertility
#20
Fatma Ferda Verit, Fadile Yildiz Zeyrek, Ali Galip Zebitay, Hurkan Akyol
OBJECTIVE: Growing evidence suggests that increased cardiovascular disease (CVD) risk is associated with female infertility caused by conditions such as polycystic ovarian disease, obesity, thyroid dysfunction, and endometriosis. The aim of this study was to evaluate whether any relationship exists between CVD and unexplained infertility. METHODS: Sixty-five women with unexplained infertility and 65 fertile controls were enrolled in the study. CVD risk markers such as low-density lipoprotein (LDL), high-density lipoprotein (HDL), total cholesterol (TC), triglycerides (TG), insulin resistance (defined by the homeostasis model assessment ratio), and high-sensitivity C-reactive protein (hs-CRP) were assessed...
March 2017: Clinical and Experimental Reproductive Medicine
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