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Polycystic ovarian disease

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https://www.readbyqxmd.com/read/29765334/high-frequency-electrical-modulation-of-the-superior-ovarian-nerve-as-a-treatment-of-polycystic-ovary-syndrome-in-the-rat
#1
Victor Pikov, Arun Sridhar, Hernan E Lara
The polycystic ovary syndrome (PCOS) is the most prevalent ovarian pathology in women, with excessive sympathetic activity in the superior ovarian nerve (SON) playing an important role in inducing the PCOS symptoms in the rats and humans. Our previous studies have shown that surgical transection of the SON can reverse the disease progression, prompting us to explore the effect of the kilohertz frequency alternating current (KHFAC) modulation as a method of reversible non-surgical suppression of the nerve activity in the rodent model of PCOS...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29752839/the-role-of-mtor-in-ovarian-cancer-polycystic-ovary-syndrome-and-ovarian-aging
#2
REVIEW
Jin Liu, Dai-Chao Wu, Li-Hua Qu, Hong-Qing Liao, Mei-Xiang Li
The mammalian target of rapamycin, mTOR, is a serine-threonine protein kinase downstream of the phosphatidylinositol 3-kinase (PI3K)-AKT axis. The pathway can regulate cell growth, proliferation, and survival by activating ribosomal kinases. Recent studies have implicated the mTOR signaling pathway in ovarian neoplasms, polycystic ovary syndrome (PCOS) and premature ovarian failure (POF). Preclinical investigations have demonstrated that the PI3K/AKT/mTOR pathway is frequently activated in the control of various ovarian functions...
May 12, 2018: Clinical Anatomy
https://www.readbyqxmd.com/read/29750655/metabolic-risk-factors-in-adolescent-girls-with-type-1-diabetes
#3
Cíntia Castro-Correia, Rita Santos-Silva, Marta Pinheiro, Carla Costa, Manuel Fontoura
BACKGROUND: The incidence of pediatric metabolic syndrome (MS) has progressively increased. The incidence of type 1 diabetes mellitus (T1DM) has also increased. Thus, some children and adolescents with T1DM exhibit MS parameters. The aim of the study was to evaluate the presence of MS parameters in female adolescents with T1DM based on their nutritional status. METHODS: We evaluated 44 adolescents with T1DM (consecutive non-randomized sample) aged between 14 and 18 years, who were on intensive therapy with insulin...
May 11, 2018: Journal of Pediatric Endocrinology & Metabolism: JPEM
https://www.readbyqxmd.com/read/29739273/angiogenic-dysregulation-in-pregnancy-related-hypertension-a-role-for-metformin
#4
Nerolen Soobryan, Saravanakumar Murugesan, Arunagiri Pandiyan, Jagidesa Moodley, Irene Mackraj
In the face of escalating maternal and fetal health threats, hypertensive pregnancy disorders (HPDs) is one of the leading cause of maternal and fetal morbidity and mortality. The range of HPDs include white-coat hypertension, chronic hypertension, gestational hypertension, mild-to-moderate and severe preeclampsia and eclampsia. Current evidence implicates an imbalance of circulating anti- and angiogenic factors in HPDs emanating from the placental vasculature, impacting on angiogenesis. Delivery of the fetus is thus far the only curative measure, albeit with increased risk...
January 1, 2018: Reproductive Sciences
https://www.readbyqxmd.com/read/29730813/predictive-factors-of-gestational-diabetes-in-pregnancies-following-assisted-reproductive-technology-a-nested-case-control-study
#5
Azam Kouhkan, Mohammad E Khamseh, Ashraf Moini, Reihaneh Pirjani, Ameneh Ebrahim Valojerdi, Arezoo Arabipoor, Roya Hosseini, Hamid Reza Baradaran
PURPOSE: To evaluate predictive factors for gestational diabetes mellitus (GDM) in singleton pregnancy following assisted reproductive technology (ART). METHODS: This nested case-control study was performed during October 2016-June 2017. Pregnant women who conceived following ART procedures referred to infertility clinic were selected and categorized into GDM and non-GDM based on ADA/IAPDSG criteria. The study variables including age, educational status, first-degree family history of chronic diseases, systolic and diastolic blood pressure, previous obstetric and perinatal outcomes, infertility history, and ART cycle characteristics were collected from medical records...
May 5, 2018: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/29720538/sympathetic-innervation-regulates-macrophage-activity-in-rat-with-polycystic-ovary
#6
Florencia Figueroa, Gisela Mendoza, Dario Cardozo, Fabian Mohamed, Liliana Oliveros, Myriam Liliana Forneris
Polycystic ovary syndrome (PCOS) is a low grade inflammatory disease characterized by hyperandrogenism and ovarian hyperinnervation. The aim of this work is to investigate whether in vivo bilateral superior ovarian nerve (SON) section in adult rats with estradiol valerate induced polycystic ovarian syndrome (PCO rats) affects macrophage spleen cells (MФ) and modifies the steroidogenic ability of their secretions. Culture media of MФ from PCO rats and PCO rats with SON section (PCO-SON rats) were used to stimulate in vitro intact ovaries...
May 2, 2018: Journal of Endocrinology
https://www.readbyqxmd.com/read/29693142/microrna-33b-5p-is-overexpressed-and-inhibits-glut4-by-targeting-hmga2-in-polycystic-ovarian-syndrome-an-in-vivo-and-in-vitro-study
#7
Ying Yang, Hua Jiang, Ling Xiao, Xuezhou Yang
Polycystic ovary syndrome (PCOS) is a common endocrine and metabolic disease, but its pathogenesis remains largely unknown. The present study explored the role of microRNA‑33b‑5p (miR‑33b‑5p) in PCOS pathogenesis, with a particular focus on its role in regulating glucose transporter 4 (GLUT4). A rat model of PCOS was developed by injecting female SD rats with insulin and HCG. miR‑33b‑5p, GLUT4, sterol regulatory element‑binding protein 1 (SREBF1), and high mobility group A2 (HMGA2) expression in rat ovarian tissues was examined by qRT‑PCR and immunohistochemistry...
April 18, 2018: Oncology Reports
https://www.readbyqxmd.com/read/29681710/possible-link-between-stress-related-factors-and-altered-body-composition-in-women-with-polycystic-ovarian-syndrome
#8
Barnali Ray Basu, Olivia Chowdhury, Sudip Kumar Saha
Background: Stress is an invisible factor affecting modern day living and is strongly associated with many disease pathogenesis including polycystic ovarian syndrome (PCOS) in women. PCOS is the most frequent endocrinological disorder that affects women of reproductive age, leading to metabolic dysfunction and body composition alterations. Salivary amylase and cortisol are major stress mediators that have been implicated in PCOS. However, their role in altering body composition in PCOS is yet to be deciphered...
January 2018: Journal of Human Reproductive Sciences
https://www.readbyqxmd.com/read/29673077/maternal-factors-associated-with-offspring-polycystic-ovarian-syndrome
#9
Anne Z Steiner
In this Swedish national registry-based cohort study Valgeirsdottir et al. sought to determine the association between 1) in-utero exposures and 2) birth indices and the subsequent development of polycystic ovarian syndrome (PCOS) after age 15. To do this, they selected 681,123 girls, whose birth was recorded in the Swedish birth registry between 1982 and 1995. They followed the girls in the Swedish Patient Registry until 2010 for a diagnosis of PCOS using International Classification of Diseases (ICD) codes...
April 19, 2018: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/29663637/reproductive-health-obesity-and-cardiometabolic-risk-factors-among-samoan-women
#10
H Maredia, N L Hawley, G Lambert-Messerlian, U Fidow, M S Reupena, T Naseri, S T McGarvey
OBJECTIVES: Obesity leads to deleterious effects on not only cardiovascular health but also on the reproductive health of women. We estimate the prevalence of menstrual irregularity and of polycystic ovarian syndrome (PCOS) in Samoan women, among whom obesity prevalence is extremely high. We explore the association of these reproductive health conditions with adiposity, cardiometabolic risk factors, and androgen levels. METHODS: A cross-sectional sample of Samoan women 25-39 years of age (n = 470) from a larger population-based genome-wide association study of adiposity and cardiometabolic disease was assessed for the prevalence of oligomenorrhea/amenorrhea (OM/AM) using a self-reported questionnaire...
April 16, 2018: American Journal of Human Biology: the Official Journal of the Human Biology Council
https://www.readbyqxmd.com/read/29615083/therapeutic-potentials-of-quercetin-in-management-of-polycystic-ovarian-syndrome-using-letrozole-induced-rat-model-a-histological-and-a-biochemical-study
#11
Sarwat Jahan, Abira Abid, Sidra Khalid, Tayyaba Afsar, Qurat-Ul-Ain, Ghazala Shaheen, Ali Almajwal, Suhail Razak
BACKGROUND: PCOS is a leading endocrinopathy of young women instigating androgens elevation, insulin resistance, obesity, cardiometabolic and menstrual complications. The study investigated the effects of quercetin in a letrozole induced rat model of polycystic ovarian syndrome, which displayed both clinical and metabolic features as in PCOS women. METHODS: Female Sprague Dawley (SD) rats were divided into four groups; control group received aqueous solution of carboxymethyl (CMC 0...
April 3, 2018: Journal of Ovarian Research
https://www.readbyqxmd.com/read/29601613/an-acne-survey-from-the-world-s-largest-annual-gathering-of-twins
#12
Amanda Suggs, Mathew Loesch, Harib Ezaldein, Luisa Christensen, Danyelle Dawes, Elma Baron
IMPORTANCE: Surveying identical twins allows us to qualitatively separate genetic and environmental factors that may contribute to acne severity. OBJECTIVE: To study a cohort of identical and fraternal twins to identify environmental factors that may influence acne severity. DESIGN, SETTING, PARTICIPANTS: A survey was administered to 139 identical and fraternal twin multiples (279 subjects) at the Annual Twins Day Festival in Twinsburg, Ohio on August 6-7, 2016...
April 1, 2018: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/29555319/fertility-and-infertility-definition-and-epidemiology
#13
REVIEW
Mélodie Vander Borght, Christine Wyns
Infertility is a disease characterized by the failure to establish a clinical pregnancy after 12 months of regular and unprotected sexual intercourse. It is estimated to affect between 8 and 12% of reproductive-aged couples worldwide. Males are found to be solely responsible for 20-30% of infertility cases but contribute to 50% of cases overall. Secondary infertility is the most common form of female infertility around the globe, often due to reproductive tract infections. The three major factors influencing the spontaneous probability of conception are the time of unwanted non-conception, the age of the female partner and the disease-related infertility...
March 16, 2018: Clinical Biochemistry
https://www.readbyqxmd.com/read/29537383/abnormal-uterine-bleeding-in-adolescents
#14
Selin Elmaoğulları, Zeyra Aycan
Abnormal uterine bleeding (AUB) is the major gynecologic complaint of adolescents admitting to hospital. Heavy menstrual bleeding (HMB) is the most common clinical presentation of AUB. Anovulatory cycles owing to immature hypothalamic-pituitary-ovarian axis is the leading etiology of HMB and there is an accompanying bleeding disorder in almost %20 of patients with HMB. Additionally, endocrine disorders such as hypothyroidism, hyperprolactinemia and polycystic ovary syndrome (PCOS) are possible causes of AUB...
February 28, 2018: Journal of Clinical Research in Pediatric Endocrinology
https://www.readbyqxmd.com/read/29525066/-diffuse-hypertrichosis-revealing-non-classical-congenital-adrenal-hyperplasia
#15
C Berthin, P Sibilia, J Martins-Hericher, A Donzeau, L Martin
BACKGROUND: Non-classical congenital adrenal hyperplasia (NC-CAH) is a recessive autosomal disease caused by a deficiency of adrenal steroidogenesis enzymes. It must be distinguished from classical CAH, either simple virilising or salt-wasting, diagnosed during the neonatal period and responsible for potentially lethal disorders of sexual differentiation. NC-CAH presents a simpler and less specific clinical picture. Herein, we present two cases comprising twin girls consulting for diffuse hypertrichosis...
April 2018: Annales de Dermatologie et de Vénéréologie
https://www.readbyqxmd.com/read/29505837/expression-profiles-of-mrna-and-long-noncoding-rna-in-the-ovaries-of-letrozole-induced-polycystic-ovary-syndrome-rat-model-through-deep-sequencing
#16
Lu-Lu Fu, Ying Xu, Dan-Dan Li, Xiao-Wei Dai, Xin Xu, Jing-Shun Zhang, Hao Ming, Xue-Ying Zhang, Guo-Qing Zhang, Ya-Lan Ma, Lian-Wen Zheng
Polycystic ovary syndrome (PCOS) is one of the most common endocrine disorders in reproductive-aged women. However, the exact pathophysiology of PCOS remains largely unclear. We performed deep sequencing to investigate the mRNA and long noncoding RNA (lncRNA) expression profiles in the ovarian tissues of letrozole-induced PCOS rat model and control rats. A total of 2147 mRNAs and 158 lncRNAs were differentially expressed between the PCOS models and control. Gene ontology analysis indicated that differentially expressed mRNAs were associated with biological adhesion, reproduction, and metabolic process...
May 30, 2018: Gene
https://www.readbyqxmd.com/read/29473360/-exploration-of-the-meridian-differentiation-law-in-polycystic-ovarian-syndrome-of-hirsutism-based-on-data-mining-technology
#17
Lingyu Shen, Yu Xing, Qiudan Lu, Cuimei Liang, Wenjin Yang, Hui Hu
OBJECTIVE: To analyze the distribution characteristics of hirsutism and the law of meridian differentiation in polycystic ovarian syndrome (PCOS). METHODS: For the patients of PCOS, the modified Ferriman-Gallwey score (mF-G score) was adopted to evaluate the hirsutism distribution. The clementine data mining software was used to analyze the distribution region of hirsutism and the correlation with meridian. RESULTS: A total of 141 patients of PCOS participated in the study...
February 12, 2018: Zhongguo Zhen Jiu, Chinese Acupuncture & Moxibustion
https://www.readbyqxmd.com/read/29462993/the-biased-g-protein-coupled-receptor-agonism-bridges-the-gap-between-the-insulin-receptor-and-the-metabolic-syndrome
#18
REVIEW
Iryna Liauchonak, Fady Dawoud, Yatin Riat, Bessi Qorri, Manpreet Sambi, Justin Jain, Regina-Veronicka Kalaydina, Nicole Mendonza, Komal Bajwa, Myron R Szewczuk
Insulin signaling, as mediated through the insulin receptor (IR), plays a critical role in metabolism. Aberrations in this signaling cascade lead to several pathologies, the majority of which are classified under the umbrella term "metabolic syndrome". Although many of these pathologies are associated with insulin resistance, the exact mechanisms are not well understood. One area of current interest is the possibility of G-protein-coupled receptors (GPCRs) influencing or regulating IR signaling. This concept is particularly significant, because GPCRs have been shown to participate in cross-talk with the IR...
February 17, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29452776/women-specific-risk-factors-for-heart-failure-a-genetic-approach
#19
REVIEW
Jet van der Kemp, Yvonne T van der Schouw, Folkert W Asselbergs, N Charlotte Onland-Moret
Heart failure is a complex disease, which is presented differently by men and women. Several studies have shown that reproductive factors, such as age at natural menopause, parity and polycystic ovarian syndrome (PCOS), may play a role in the development of heart failure. Shared genetics may provide clues to underlying mechanisms; however, this has never been examined. Therefore, the aim of the current study was to explore whether any reproductive factor is potentially related to heart failure in women, based on genetic similarities...
March 2018: Maturitas
https://www.readbyqxmd.com/read/29440921/adult-onset-acne-prevalence-impact-and-management-challenges
#20
REVIEW
Marco A Rocha, Ediléia Bagatin
Acne is a multifactorial and inflammatory disease of pilosebaceous follicles, which affects most adolescents. Recent epidemiological data revealed a difference in adults affected by this disease. Women have a high prevalence and incidence when compared with men, especially after 25 years of age. In contrast to what was initially thought, most of these patients do not present endocrinopathy capable of leading to the development of the lesions. When present, polycystic ovarian syndrome is the main cause. However, in these cases, acne is rarely the only dermatological manifestation; hirsutism and acanthosis nigricans are often present...
2018: Clinical, Cosmetic and Investigational Dermatology
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