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Diabetes type1

Daniel E Alonso Martín, M Belén Roldán Martín, M Ángeles Álvarez Gómez, Rosa Yelmo Valverde, María Martín-Frías, Milagros Alonso Blanco, Raquel Barrio Castellanos
INTRODUCTION: Diabetes education is an essential tool to achieve treatment objectives in type1 diabetes mellitus (T1DM). The aim of this study was to determine if understanding of diabetes by caregivers/patients or sociodemographic factors affect blood glucose control in children and adolescents with T1DM. PATIENTS AND METHODS: The level of knowledge of 105 caregivers of children and adolescents with T1DM was assessed using a survey adapted to the type of treatment used (multiple dose insulin [MDI] or continuous subcutaneous insulin infusion [CSII])...
October 17, 2016: Endocrinología y Nutrición: órgano de la Sociedad Española de Endocrinología y Nutrición
Ataroalsadat Mostafavinia, Abdodlah Amini, Seyed Kamran Ghorishi, Ramin Pouriran, Mohammad Bayat
The approach and novelty of this scientific work was to formulate the appropriate Streptozotocin (STZ) and Alloxan dosage in different routes of administration to imply minimum mortality rate and high incidence of diabetes mellitus (DM) in the rat experiment model. Rats were randomly divided into STZ, Alloxan and control groups. 1-Alloxan group was divided into two subgroups: intraperitoneal (ip) subgroups which received a single dose of, 140, 120, 100 and 80 mg/kg; and the subcutaneous (sc) subgroups which received a single dose of, 120, 110, 100, 90, and 80 mg/kg...
September 2016: Laboratory Animal Research
Tuba Mumtaz, Samsaam Ali Haider, Jamil Ahmad Malik, Annette Marie La Greca
OBJECTIVE: To evaluate the efficacy of an Urdu translation of Self Care Inventory for measuring adherence to diabetes treatment. METHODS: The correlational cross-sectional study was conducted in October and November, 2011, and data was collected from outpatient department of public-sector hospitals of Rawalpindi and Islamabad, Pakistan. Patients included had diabetes type1 or type 2, while those with severe diabetic complications, including nephropathy, neuropathy, diabetic foot, and renal disease or any psychiatric comorbidity, were excluded...
July 2016: JPMA. the Journal of the Pakistan Medical Association
Daniel Pipeleers, Thomas Robert, Ines De Mesmaeker, Zhidong Ling
: : A depleted β-cell mass causes diabetes complications that cannot be avoided by insulin administration. β-Cell replacement can stop their development when restoring insulin's homeostatic role. This requires a sufficient number and an adequate functional state of the β cells, together defined as "functional β-cell mass." Intraportal implants of human pancreatic islet cells correct hyperglycemia in patients with type1 diabetes, but this effect is transient and often incomplete. Studies to improve outcome are hindered by shortage in donor pancreases...
July 5, 2016: Stem Cells Translational Medicine
Mohamed Talat, Laila Sherief, Hosam El-Saadany, Anwar Ahmed, Rabab M Saleh, Maha Sakr
OBJECTIVE: To investigate the levels of serum osteopontin in pediatric patients with type1 diabetes mellitus (T1DM) and to explored if it has a role in the prediction of diabetes complications. METHODS: This was a case-control study conducted at endocrinology unit, children's Hospital, Zagazig University, Egypt, from October 2014 to December 2015. Sixty patients with T1DM and 60 healthy subjects were enrolled. All the children were subjected to detailed medical history; full clinical examination, ophthalmoscopy ; laboratory estimation for fasting blood glucose, hemoglobin A1c (HbA1c), urine albumin / creatinine ratio and serum osteopontin...
June 29, 2016: Journal of Clinical Research in Pediatric Endocrinology
Alexander Berezin
Diabetes mellitus (DM) exhibits raised prevalence worldwide. There is a large body of evidence regarding the incidence of DM closely associates with cardiovascular (CV) complications. In this context, hyperglycaemia, oxidant stress, and inflammation are key factors that contribute in CV events and disease in type1 and type 2 DM, even when metabolic control was optimal and/or intensive glycemic control was implemented. It has been suggested that the effect of poor metabolic control or even transient episodes of hyperglycemia in DM associates in particularly with worsening ability of endogenous vasoreparative systems that are mediated epigenetic changes in several cells (progenitor cells, stem cells, mononuclears, immune cells), and thereby lead to so called "vascular glycemic memory" or "metabolic memory"...
April 2016: Diabetes & Metabolic Syndrome
Faiza Qari
OBJECTIVES: The aims of this study were assessing the frequency of clinical characteristics of patients with severe Diabetic ketoacidosis (DKA) who were admitted to the intensive care unit (ICU) and investigating the relationship between paraclinical (glucose, anion gap, and serum bicarbonate) and clinical parameters in patients with severe DKA. METHOD: A retrospective chart review of all adult patients with DKA who were admitted to the ICU at King Abdulaziz University Hospital, Jeddah, Saudi Arabia between January 2012 and December 2013...
November 2015: Pakistan Journal of Medical Sciences Quarterly
Marina Bianchi, Massimo Cartabia, Antonio Clavenna, Ida Fortino, Angela Bortolotti, Luca Merlino, Maurizio Bonati
AIM: To evaluate the temporal trend and extent of screening for celiac disease in an Italian pediatric population of incident type 1 diabetes in the period 2006-2011, providing information on adherence to guidelines in primary care. METHODS: Using the Lombardy region's administrative database, 1-17-year-old children and adolescents diagnosed with type 1 diabetes during the 2006-2011 period were identified. Among these patients, the number screened for celiac disease was calculated on the basis of specific antibodies...
June 2016: European Journal of Gastroenterology & Hepatology
Anwar T Merchant, Georges J Nahhas, R Paul Wadwa, Jiajia Zhang, Yifan Tang, Lonnie R Johnson, David M Maahs, Franziska Bishop, Ricardo Teles, Elaine H Morrato
BACKGROUND: A subset of periodontal microorganisms has been associated with cardiovascular disease (CVD), which is the leading complication of type 1 diabetes (t1DM). The authors therefore evaluated the association between periodontal microorganism groups and early markers of CVD in youth with t1DM. METHODS: A cross-sectional analysis was conducted among youth aged 12 to 19 years at enrollment; 105 had t1DM for ≥5 years and were seeking care at the Barbara Davis Center, University of Colorado, from 2009 to 2011, and 71 did not have diabetes...
April 2016: Journal of Periodontology
Maria Granfors, Hanna Augustin, Johnny Ludvigsson, Hilde K Brekke
BACKGROUND: Sweden has the second highest incidence of type 1 diabetes in the world. Nutritional aspects in utero and in infancy affect the development. We conducted a survey to determine whether reported maternal use of vitamin D-containing micronutrient supplements during pregnancy was associated with the risk of developing type 1 diabetes in the child. METHODS: This report was based on data from the ABIS (All Babies In Southeast Sweden) study, with questionnaire data on 16 339 mother and infant pairs at birth and at 1-yr of age (n = 10 879), of whom 108 children were registered with type 1 diabetes before 14-16 yr of age...
November 2016: Pediatric Diabetes
Manna Zhang, Yan Li, Wenjie Cui, Peng Yang, Hong Li, Chunjun Sheng, Xiaoyun Cheng, Shen Qu
OBJECTIVE: To investigate the prevalence and clinical characteristics of ketosis-prone type 2 diabetes (KPD) in Chinese patients with young-onset diabetes. METHODS: A total of 238 young diabetic patients were recruited from our inpatient department from January 1, 2012, to December 28, 2014. KPD was defined as diabetes without precipitating illness and with the presence of ketosis or diabetic ketoacidosis in the absence of autoantibodies at the time of diagnosis...
December 2015: Endocrine Practice
Hamidreza Iranpoor, Eskandar Omidinia, Venus Vatankhah, Vahid Gharanjik, Majid Shahbazi
BACKGROUND: Human insulin-like growth factor type 1 (hIGF-1) is a protein consisting of 70 amino acids (MW=7.6 kDa) and mainly synthesized by liver. Mecasermin (Trade name INCRELEX) is the synthetic form of the protein which is used as an effective treatment for particular disorders such as short stature, type 1 and 2 diabetes, and wound healing. Current study was aimed to investigate the expression of human insulin-like growth factor type1 in Escherichia coli (E. coli) BL21 (DE3) expression system in order to produce an active recombinant form of the protein...
July 2015: Avicenna Journal of Medical Biotechnology
Yung-Po Liaw, Pei-Chieh Ko, Shiou-Rung Jan, Jing-Yang Huang, Oswald Ndi Nfor, Chia-Chi Lung, Yi-Chen Chiang, Liang-Tsai Yeh, Ming-Chih Chou, Horng-Der Tsai, Yi-Hsuan Hsiao
AIM: The current study assessed the potential impact of diabetes type 1 and type 2 for female breast cancer risk. MATERIALS AND METHODS: The health information and medical record of the entire adult female residents in Taiwan were retrieved from Taiwan's National Health Insurance Research Database. Multivariate Cox proportional hazard regression models and descriptive statistics were used to identify potential correlations between type 1/2 diabetes and breast cancer...
2015: Journal of Cancer
David Martin, Yung-Hae Kim, Dror Sever, Chai-An Mao, Jacques-Antoine Haefliger, Anne Grapin-Botton
To contribute to devise successful beta-cell differentiation strategies for the cure of Type 1 diabetes we sought to uncover barriers that restrict endocrine fate acquisition by studying the role of the transcriptional repressor REST in the developing pancreas. Rest expression is prevented in neurons and in endocrine cells, which is necessary for their normal function. During development, REST represses a subset of genes in the neuronal differentiation program and Rest is down-regulated as neurons differentiate...
September 15, 2015: Developmental Biology
M R King, N J Anderson, C Liu, E Law, M Cundiff, T M Mixcoatl-Zecuatl, C G Jolivalt
Peripheral neuropathy is a major complication associated with diabetes and central neuropathy characterized by Alzheimer's disease-like features in the brain is associated with increased dementia risk for patients with diabetes. Although glucose uptake into the cells of the nervous system is insulin-independent, contribution of impaired insulin support is clearly recognized to play a role, however not yet fully understood, in the development of neuropathy. In this study, we assessed the direct role of insulin on the peripheral nervous system (PNS) and central nervous system (CNS) of insulin-dependent type 1 diabetic rats...
September 10, 2015: Neuroscience
Kexin Wang, Yu Sun, Peng Lin, Jun Song, Ruxing Zhao, Wenjuan Li, Xinguo Hou, Chuan Wang, Lingshu Wang, Ping Zhu, Li Chen
β-Cell insufficiency plays an important role in the development of diabetes. Environmental factors, including lifestyle, play a critical role in β-cell dysfunction. Modern lifestyles affect the inherent circadian clock in central and peripheral organs. Recent studies have demonstrated that the normal intrinsic circadian clock in islets was essential for the viability of β cells and their insulin secretory function. Overall, however, the data are inconclusive. Our study demonstrated that the disrupted circadian rhythm of islets in streptozotocin induced type1 diabetic mice may be associated with impaired β-cell function and glucose intolerance...
2015: Biological & Pharmaceutical Bulletin
Kazuhiko Bando, Daizo Ebisutani
Here, we report the case of a woman with multiple endocrine neoplasia type 1(MEN1) who experienced hypoglycemic attacks. At the age of 59, she underwent parathyroid tumor resection for hyperparathyroidism. At the age of 65, she presented with dizziness at our hospital. Magnetic resonance imaging (MRI) revealed a left cerebellopontine (CP) angle tumor and a pituitary tumor. The CP angle tumor (acoustic neurionoma) was removed;the pituitary adenoma (prolactinoma) was managed by using bromocriptine. At the age of 77, she lost consciousness and was transferred to a local hospital...
May 2015: No Shinkei Geka. Neurological Surgery
Giulia Donvito, Isabella Bettoni, Francesca Comelli, Anita Colombo, Barbara Costa
We previously demonstrated that the intraperitoneal administration of palmitoylethanolamide (PEA) in mice with chronic constriction injury of the sciatic nerve evoked a relief of both thermal hyperalgesia and mechanical allodynia in neuropathic mice. Since diabetic neuropathy is one of the most common long-term complications of diabetes, we explored the ability of PEA to also relief this kind of chronic pain, employing the well established streptozotocin-induced animal model of type 1 diabetes. Our findings demonstrated that PEA relieves mechanical allodynia, counteracts nerve growth factor deficit, improves insulin level, preserves Langerhans islet morphology reducing the development of insulitis in diabetic mice...
2015: CNS & Neurological Disorders Drug Targets
Adrian Sayers, Daniel Thayer, John N Harvey, Stephen Luzio, Mark D Atkinson, Robert French, Justin T Warner, Colin M Dayan, Susan F Wong, John W Gregory
OBJECTIVES: To estimate the excess in admissions associated with type1 diabetes in childhood. DESIGN: Matched-cohort study using anonymously linked hospital admission data. SETTING: Brecon Group Register of new cases of childhood diabetes in Wales linked to hospital admissions data within the Secure Anonymised Information Linkage Databank. POPULATION: 1577 Welsh children (aged between 0 and 15 years) from the Brecon Group Register with newly-diagnosed type-1 diabetes between 1999-2009 and 7800 population controls matched on age, sex, county, and deprivation, randomly selected from the local population...
2015: BMJ Open
Yoshiro Kato, Hideki Kamiya, Naoki Koide, Erdenezaya Odkhuu, Takayuki Komatsu, Atsuko Watarai, Masaki Kondo, Koichi Kato, Jiro Nakamura, Takashi Yokochi
High-mobility group box 1 (HMGB1) is suggested to participate in development of local and systemic inflammatory disorders. Irbesartan (IRB), an angiotensin II type1 receptor blocker, is widely used for treatment of hypertension, especially in patients with diabetic nephropathy. The effect of IRB on lipopolysaccharide (LPS)-induced HMGB1 and nitric oxide (NO) production was examined using RAW 264.7 macrophage-like cells. IRB inhibited LPS-induced HMGB1 production. IRB also reduced LPS-induced expression of an inducible NO synthase, and inhibited LPS-induced NO production...
May 2015: International Immunopharmacology
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