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https://www.readbyqxmd.com/read/29036259/autoimmune-progesterone-dermatitis-a-diagnosis-to-consider-in-a-patient-with-cyclical-cutaneous-eruptions
#1
Alexa B Steuer, Sharon Scherl, Robin Ashinoff
Autoimmune progesterone dermatitis (APD) is a cyclical cutaneous reaction to progesterone, with symptoms that typically begin 3-10 days before the onset of menstrual flow and end 1-2 days into menses. The symptoms vary in severity from barely visible to anaphylaxis, but most often include an eczematous eruption, erythema multiforme, urticaria, folliculitis, and angioedema. This is a rare disorder with only a handful of documented cases. The pathogenesis of this condition remains unknown and significant variations in the presentation and severity of symptoms complicates its diagnosis...
October 1, 2017: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/29031417/-skin-pigmentation-induced-by-meropenem-and-levofloxacin
#2
E Garval, V Vuiblet, A Durlach, G Perceau, D Anuset, P Bernard
BACKGROUND: Various cutaneous side-effects, including, exanthema, pruritus, urticaria and Lyell or Stevens-Johnson syndrome, have been reported with meropenem (carbapenem), a rarely-prescribed antibiotic. Levofloxacin (fluoroquinolone), a more frequently prescribed antibiotic, has similar cutaneous side-effects, as well as photosensitivity. We report a case of cutaneous hyperpigmentation induced by meropenem and levofloxacin. PATIENTS AND METHODS: A 67-year-old male was treated with meropenem (1g×4 daily), levofloxacin (500mg twice daily) and amikacin (500mg daily) for 2 weeks, followed by meropenem, levofloxacin and rifampicin (600mg twice daily) for 4 weeks for osteitis of the fifth metatarsal...
October 11, 2017: Annales de Dermatologie et de Vénéréologie
https://www.readbyqxmd.com/read/29024017/most-common-dermatology-diagnoses-to-the-emergency-department-in-the-pediatric-population
#3
Anish Nadkarni, Leah A Cardwell, Simon Mahler, Steven R Feldman
Skin related complaints are a top 10 reason for pediatric presentation to the ED. Older studies and those conducted outside of the US demonstrate wide variability in the frequency of pediatric presentations to the ED for skin complaints, ranging from 4-40% of visits.(1) One study found urticaria to be the most frequent PED dermatological diagnosis, while others found viral exanthema and contact dermatitis to be the most common diagnoses. This article is protected by copyright. All rights reserved.
October 10, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28993062/chronic-spontaneous-urticaria-and-the-extrinsic-coagulation-system
#4
REVIEW
Yuhki Yanase, Shunsuke Takahagi, Michihiro Hide
Chronic spontaneous urticaria (CSU) is a common skin disorder characterized by daily or almost daily recurring skin edema and flare with itch. Recently, the activation of the blood coagulation cascade has been suggested to be involved in CSU, but the trigger of the coagulation cascade remains unclear. In this article, we review recent understanding of the relationship between the pathogenesis of CSU and extrinsic coagulation reactions. In CSU, vascular endothelial cells and eosinophils may play a role as TF-expressing cells for activating the extrinsic coagulation pathway...
October 6, 2017: Allergology International: Official Journal of the Japanese Society of Allergology
https://www.readbyqxmd.com/read/28988786/omalizumab-for-severe-chronic-spontaneous-urticaria-real-life-experiences-of-280-patients
#5
Zahava Vadasz, Yuval Tal, Menachem Rotem, Vered Shichter-Confino, Keren Mahlab-Guri, Yael Graif, Aharon Kessel, Nancy Agmon-Levin, Ramit Maoz-Segal, Shmuel Kivity, Shira Benor, Idit Lachover-Roth, Yuri Zeldin, Migel Stein, Ori Toker, Gamal Hassoun, Shira Bezalel-Rosenberg, Elias Toubi, Ilan Asher, Zev Sthoeger
No abstract text is available yet for this article.
October 4, 2017: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/28983950/epidemiology-and-comorbidities-of-patients-with-chronic-urticaria-in-korea-a-nationwide-population-based-study
#6
Bo Ri Kim, Seungkeol Yang, Jee Woong Choi, Chong Won Choi, Sang Woong Youn
Few population-based studies have focused on the epidemiology and comorbidities of chronic urticaria (CU) or chronic spontaneous urticaria (CSU). The objective of this study was to obtain information on the epidemiology and comorbidities associated with CU and CSU in Korea. We conducted a cross-sectional analysis using a national health insurance database. An algorithm based on the International Classification of Diseases, 10th revision, was used for the identification of patients with CU and CSU, and an age-sex adjusted logistic regression model was used to assess the risk of comorbidities in these patients...
October 6, 2017: Journal of Dermatology
https://www.readbyqxmd.com/read/28983485/anti-ige-treatment-for-disorders-other-than-asthma
#7
REVIEW
Jeffrey Stokes
Immunoglobulin E (IgE) plays a key role in the pathogenesis of many allergic diseases. Thus, IgE-mediated immunologic pathways are an attractive target for intervention in allergic diseases. Omalizumab is a recombinant humanized monoclonal antibody that binds IgE and has been used treat allergic asthma for over a decade. Currently, omalizumab is approved for the treatment of both allergic asthma and chronic spontaneous urticaria. Since IgE plays a critical role in other allergic diseases, anti-IgE therapy has been evaluated in other allergic diseases in small clinical trials and case reports...
2017: Frontiers in Medicine
https://www.readbyqxmd.com/read/28979025/urticaria-and-angioedema-associated-with-haloperidol
#8
Manisha Balai, Farzana Ansari, Lalit Kumar Gupta, Ashok Kumar Khare, Asit Kumar Mittal
No abstract text is available yet for this article.
September 2017: Indian Journal of Dermatology
https://www.readbyqxmd.com/read/28979013/subcutaneous-autologous-serum-therapy-in-chronic-spontaneous-urticaria
#9
Kiran Vasant Godse, Nitin Nadkarni, Sharmila Patil, Aayushi Mehta
BACKGROUND: There is a felt need for trying newer therapeutic modalities in patients with chronic spontaneous urticaria, especially in the subset of patients classified as non-responders to antihistamines. Autologous serum therapy is an upcoming modality of treatment, and we decided to study its efficacy by subcutaneous route. AIMS: To evaluate the effectiveness of subcutaneous autologous serum therapy (AST) in CSU. METHODS: This was a single blind, placebo-controlled parallel group, randomized, controlled study...
September 2017: Indian Journal of Dermatology
https://www.readbyqxmd.com/read/28975215/infantile-onset-fever-and-urticaria
#10
Sukesh Sukumaran, Vini Vijayan
No abstract text is available yet for this article.
September 18, 2017: JAMA Pediatrics
https://www.readbyqxmd.com/read/28973428/chronic-urticaria-in-children-still-itching-for-insight
#11
Marcus Maurer, Martin K Church, Karsten Weller
No abstract text is available yet for this article.
September 27, 2017: JAMA Dermatology
https://www.readbyqxmd.com/read/28973060/evaluating-comorbidities-natural-history-and-predictors-of-early-resolution-in-a-cohort-of-children-with-chronic-urticaria
#12
Elena Netchiporouk, Denis Sasseville, Linda Moreau, Youssef Habel, Elham Rahme, Moshe Ben-Shoshan
Importance: Chronic urticaria (CU) affects 0.1% to 0.3% of children. Most cases have no identifiable trigger and are classified as chronic spontaneous urticaria (CSU). At least half of patients with CSU may have an autoimmune etiology that can be determined in vitro using the basophil activation test (BAT). While 30% to 55% of CU cases resolve spontaneously within 5 years in adults, the natural history and predictors of resolution in children are not known. Objective: To assess the comorbidities, natural history of CU, and its subtypes in children and identify predictors of resolution...
September 27, 2017: JAMA Dermatology
https://www.readbyqxmd.com/read/28971131/yellow-urticaria-and-biliary-pancreatitis
#13
Eira Mabel Nava Cruz, Juan Pablo Castanedo-Cázares, Diana Vianney Hernández Blanco, Bertha Torres-Álvarez
No abstract text is available yet for this article.
September 2017: JAAD Case Reports
https://www.readbyqxmd.com/read/28968274/critical-appraisal-of-the-unmet-needs-in-the-treatment-of-chronic-spontaneous-urticaria-with-omalizumab-an-italian-perspective
#14
Riccardo Asero, Giorgio W Canonica, Antonio Cristaudo, Maria T Fierro, Giampiero Girolomoni, Angelo V Marzano, Eustachio Nettis, Patrizia Pepe, Paolo Pigatto, Oliviero Rossi
PURPOSE OF REVIEW: The humanized anti-IgE antibody omalizumab has been available for patients with chronic spontaneous urticaria (CSU) in Italy since 2015. This review summarizes the unresolved issues and unmet therapeutic needs associated with omalizumab and discusses practical recommendations for its use in the management of CSU. RECENT FINDINGS: Although modern second-generation H1-antihistamines are the standard of care for patients with CSU, adjunctive treatments (including omalizumab) may be required for effective control of symptoms in many patients...
September 28, 2017: Current Opinion in Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28967621/successful-minimally-invasive-mitral-valve-replacement-using-normothermic-fibrillatory-arrest-in-a-patient-with-cold-urticaria
#15
James A Nelson, Simon Maltais, Jonathan J Fox, John B Hagan, Kari L Rossow, William J Mauermann
No abstract text is available yet for this article.
May 3, 2017: Journal of Cardiothoracic and Vascular Anesthesia
https://www.readbyqxmd.com/read/28965699/-giardia-duodenalis-and-its-involvement-in-skin-diseases
#16
REVIEW
P Humbert, A Guichard, I Bennani, S Chiheb
BACKGOUND: Over the last thirty years, the scientific community has become increasingly interested in the intestinal flora, whether commensal or pathogenic, and its impact on other organs. In dermatology, the correlation between intestinal microbial agents and cutaneous lesions is well established. Giardia duodenalis, an intestinal parasite, has been particularly widely studied. The aim of this work is to provide a review of studies demonstrating the involvement of G. duodenalis in various forms of dermatosis...
September 28, 2017: Annales de Dermatologie et de Vénéréologie
https://www.readbyqxmd.com/read/28957823/nlrc4-inflammasomopathies
#17
Neil Romberg, Tiphanie P Vogel, Scott W Canna
PURPOSE OF REVIEW: The purpose of the review is to highlight developments in autoinflammatory diseases associated with gain-of-function mutations in the gene encoding NLR-family CARD-containing protein 4 (NLRC4), the NLRC4-inflammasomopathies. RECENT FINDINGS: Three years since the identification of the first autoinflammation with infantile enterocolitis (AIFEC) patients, there is an improved understanding of how the NLRC4 inflammasome and interleukin 18 (IL-18) contribute to gut inflammation in myeloid and also intestinal epithelial cells...
September 27, 2017: Current Opinion in Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28951710/brain-derived-neurotrophic-factor-is-increased-in-serum-levels-of-patients-with-symptomatic-dermographism
#18
Seval Erpolat, Huseyin Tugrul Celik, Bulent Bozkurt
INTRODUCTION: Symptomatic dermographism (SD) is the most common form of physical urticaria. However, the role of neuroimmune mechanisms in SD is unclear. AIM: To investigate circulating levels of brain-derived neurotrophic factor (BDNF) in symptomatic dermographism. MATERIAL AND METHODS: Thirty-two patients suffering from SD and 33 healthy subjects were included in the study. Serum BDNF levels were determined by a human enzyme-linked immunoassay (ELISA) kit...
August 2017: Postȩpy Dermatologii i Alergologii
https://www.readbyqxmd.com/read/28950944/emerging-roles-for-mas-related-g-protein-coupled-receptor-x2-in-host-defense-peptide-opioid-and-neuropeptide-mediated-inflammatory-reactions
#19
Hydar Ali
Mast cells (MCs) are tissue-resident immune cells that contribute to host defense but are best known for their roles in allergic and inflammatory diseases. In humans, MCs are divided into two subtypes based on the protease content of their secretory granules. Thus, human lung MCs contain only tryptase and are known as MCT, whereas skin MCs contain both tryptase and chymase and are known as MCTC. Patients with severe asthma display elevated MCs in the lung, which undergo phenotypic change from MCT to MCTC. Although the human genome contains four Mas related G protein coupled receptor X (MRGPRX) genes, an important feature of MCTC is that they selectively express MRGPRX2...
2017: Advances in Immunology
https://www.readbyqxmd.com/read/28941883/a-national-survey-of-premedication-for-transfusion-reactions-in-japan
#20
Shin-Ichiro Fujiwara, Shuichi Kino, Asashi Tanaka, Yuichi Hasegawa, Akihiko Yokohama, Keizo Fujino, Makino Shigeyoshi, Mayumi Matsumoto, Akihiro Takeshita, Kazuo Muroi
BACKGROUND: Premedication before transfusion is commonly administered in clinical practice despite a lack of evidence for its efficacy. The aim of this study was to clarify the status of premedication and evaluate expert opinions regarding its use in Japanese medical institutions. METHOD: Between May and July 2016, we conducted a questionnaire survey on premedication before transfusion in 252 medical institutes that were certified by an academic society or employed transfusion experts...
September 11, 2017: Transfusion and Apheresis Science
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