Eduardo Patiño-Martinez, Shuichiro Nakabo, Kan Jiang, Carmelo Carmona-Rivera, Wanxia Li Tsai, Dillon Claybaugh, Zu-Xi Yu, Aracely Romero, Eric Bohrnsen, Benjamin Schwarz, Miguel A Solís-Barbosa, Luz P Blanco, Mohammad Naqi, Yenealem Temesgen-Oyelakim, Michael Davis, Zerai Manna, Nehal Mehta, Faiza Naz, Stephen Brooks, Stefania dell'Orso, Sarfaraz Hasni, Mariana J Kaplan
OBJECTIVE: The Krebs cycle enzyme Aconitate Decarboxylase 1 (ACOD1) mediates itaconate synthesis in myeloid cells.. Previously, we reported that administration of 4-octyl itaconate abrogated lupus phenotype in mice. Here, we explore the role of the endogenous ACOD1/itaconate pathway in the development of murine lupus as well as their relevance in premature cardiovascular damage in SLE. METHODS: We characterized Acod1 protein expression in bone marrow-derived macrophages and human monocyte-derived macrophages, following a TLR7 agonist (imiquimod, IMQ)...
February 22, 2024: medRxiv