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Opioid dependence

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https://www.readbyqxmd.com/read/29150865/enhanced-mu-opioid-receptor-dependent-opioidergic-modulation-of-striatal-cholinergic-transmission-in-dyt1-dystonia
#1
Giulia Ponterio, Annalisa Tassone, Giuseppe Sciamanna, Valentina Vanni, Maria Meringolo, Massimo Santoro, Nicola Biagio Mercuri, Paola Bonsi, Antonio Pisani
BACKGROUND: Mu opioid receptor activation modulates acetylcholine release in the dorsal striatum, an area deeply involved in motor function, habit formation, and reinforcement learning as well as in the pathophysiology of different movement disorders, such as dystonia. Although the role of opioids in drug reward and addiction is well established, their involvement in motor dysfunction remains largely unexplored. METHODS: We used a multidisciplinary approach to investigate the responses to mu activation in 2 mouse models of DYT1 dystonia (Tor1a(+/Δgag) mice, Tor1a(+/-) torsinA null mice, and their respective wild-types)...
November 18, 2017: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/29149731/purinergic-drug-targets-for-gastrointestinal-disorders
#2
REVIEW
Geoffrey Burnstock, Kenneth A Jacobson, Fievos L Christofi
Purinergic receptors are implicated in the pathogenesis of gastrointestinal disorders and are being explored as potential therapeutic targets. Gut inflammation releases ATP that acts on neuronal, glial, epithelial and immune cells. Purinergic signalling in glia and neurons is implicated in enteric neuropathies. Inflammation activates glia to increase ATP release and alter purinergic signalling. ATP release causes neuron death and gut motor dysfunction in colitis via a P2X7-dependent neural-glial pathway and a glial purinergic-connexin-43 pathway...
November 14, 2017: Current Opinion in Pharmacology
https://www.readbyqxmd.com/read/29148954/our-life-depends-on-this-drug-competence-inequity-and-voluntary-consent-in-clinical-trials-on-supervised-injectable-opioid-assisted-treatment
#3
Daniel Steel, Kirsten Marchand, Eugenia Oviedo-Joekes
Supervised injectable opioid assisted treament (siOAT) prescribes injectable opioids to individuals for whom other forms of addiction treatment have been ineffective. In this article, we examine arguments that opioid-dependent people should be assumed incompetent to voluntarily consent to clinical research on siOAT unless proven otherwise. We agree that concerns about competence and voluntary consent deserve careful attention in this context. But we oppose framing the issue solely as a matter of the competence of opioid-dependent people and emphasize that it should be considered in the context of inequities in access to siOAT as a medical treatment...
December 2017: American Journal of Bioethics: AJOB
https://www.readbyqxmd.com/read/29148934/reconciling-competence-and-consent-in-opioid-dependence-research-the-value-of-vulnerability-rhetoric
#4
Michael O S Afolabi, Stephen O Sodeke
No abstract text is available yet for this article.
December 2017: American Journal of Bioethics: AJOB
https://www.readbyqxmd.com/read/29148881/ultrarapid-influence-of-buprenorphine-on-major-depression-in-opioid-dependent-patients-a-double-blind-randomized-clinical-trial
#5
Jamshid Ahmadi, Mina Sefidfard Jahromi
OBJECTIVE: To examine the impact of different doses of buprenorphine on depression symptoms in opioid dependent inpatient over a three-day interval, using a randomized clinical trial design (RCT). DESIGN: Patients were randomized and assigned to three groups. PARTICIPANTS: Forty males who were admitted to an inpatient psychiatric unit and who fulfilled the DSM-5 criteria for both opioid dependence and major depressive disorder. INTERVENTION: Patients randomly received 32 mg, 64 mg, or 96 mg of buprenorphine as a single high dose...
November 17, 2017: Substance Use & Misuse
https://www.readbyqxmd.com/read/29148826/engagement-in-the-overdose-risk-information-orion-e-health-tool-for-opioid-overdose-prevention-and-self-efficacy-a-preliminary-study
#6
Giuseppe Carrà, Cristina Crocamo, Gerald Humphris, Tommaso Tabacchi, Francesco Bartoli, Julia Neufeind, Norbert Scherbaum, Alexander Baldacchino
Increasing awareness of, and information about, overdose risk is an appropriate approach in risk reduction. e-Health technology in substance use disorders is an opportunity to support behavioral changes related to public health concerns. The present study aimed to evaluate the short-term impact of an innovative e-health psychoeducational software, the Overdose RIsk InfOrmatioN (ORION) tool. The ORION programme provided relevant information to opioid-dependent individuals about the risk of suffering a drug overdose as a result of high risky and dysfunctional behaviors...
November 17, 2017: Cyberpsychology, Behavior and Social Networking
https://www.readbyqxmd.com/read/29146238/ccr5-mediates-hiv-1-tat-induced-neuroinflammation-and-influences-morphine-tolerance-dependence-and-reward
#7
Maciej Gonek, Virginia D McLane, David L Stevens, Kumiko Lippold, Hamid I Akbarali, Pamela E Knapp, William L Dewey, Kurt F Hauser, Jason J Paris
The HIV-1 regulatory protein, trans-activator of transcription (Tat), interacts with opioids to potentiate neuroinflammation and neurodegeneration within the CNS. These effects may involve the C-C chemokine receptor type 5 (CCR5); however, the behavioral contribution of CCR5 on Tat/opioid interactions is not known. Using a transgenic murine model that expresses HIV-1 Tat protein in a GFAP-regulated, doxycycline-inducible manner, we assessed morphine tolerance, dependence, and reward. To assess the influence of CCR5 on these effects, mice were pretreated with oral vehicle or the CCR5 antagonist, maraviroc, prior to morphine administration...
November 13, 2017: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/29143483/the-impact-of-mental-health-comorbidities-on-adherence-to-buprenorphine-a-claims-based-analysis
#8
Megan Litz, Douglas Leslie
BACKGROUND AND OBJECTIVES: Previous research has been inconclusive about whether opioid-dependent patients with psychiatric comorbidities have shorter treatment retention and higher relapse rates. This study aims to evaluate the impact of mental health comorbidities on adherence to buprenorphine using a large, national health insurance claims data base. METHODS: We used MarketScan® data from 2012 to 2014 to perform this analysis. Inclusion criteria included all patients with an opioid use disorder-related ICD-9 code who had been prescribed buprenorphine (n = 2947)...
November 16, 2017: American Journal on Addictions
https://www.readbyqxmd.com/read/29143401/assessment-of-risk-behaviors-in-patients-with-opioid-prescriptions-a-study-of-indiana-s-inspect-data
#9
Marion S Greene, Robert Andrew Chambers, Constantin T Yiannoutsos, Eric R Wright, Gregory K Steele, Terrell W Zollinger
BACKGROUND AND OBJECTIVES: Prescription Drug Monitoring Programs (PDMPs) can serve as screening tools and support the clinical decision-making process in patients receiving opioids. The objective of the study was to utilize 2014 INSPECT (Indiana's PDMP) data to identify factors that increase patients' likelihood to engage in opioid-related risk behaviors. METHODS: Based on a literature review, four risk behaviors were identified: Receiving >90 morphine milligram equivalents (MME), having >4 opioid prescribers, obtaining opioids from >4 pharmacies, and concurrent use of opioids and benzodiazepines...
November 16, 2017: American Journal on Addictions
https://www.readbyqxmd.com/read/29143399/buprenorphine-naloxone-treatment-responses-differ-between-young-adults-with-heroin-and-prescription-opioid-use-disorders
#10
Mauricio Romero-Gonzalez, Abtin Shahanaghi, Gregory J DiGirolamo, Gerardo Gonzalez
BACKGROUND AND OBJECTIVES: Opioid use disorder among young adults is rising sharply with an increase in morbidity and mortality. This study examined differences in treatment response to a fixed dose of buprenorphine-naloxone between heroin (HU) and prescriptions opioids (POU) users. METHODS: Eighty opioid dependent young adults (M = 22 years) were treated with buprenorphine-naloxone 16-4 mg/day for 8 weeks. Differences between HU (N = 17) and POU (N = 63) on changes in weekly opioid use, opioid craving, withdrawal, and depression symptoms were analyzed with mixed-effects regression models...
November 16, 2017: American Journal on Addictions
https://www.readbyqxmd.com/read/29142795/comorbid-post-traumatic-stress-disorder-and-opioid-dependence
#11
Rikinkumar S Patel, Ahmed Elmaadawi, Suhayl Nasr, John Haskin
Post-traumatic stress disorder (PTSD) is predominant amongst individuals addicted to opioids and obscures the course of illness and the treatment outcome. We report the case of a patient with major depressive disorder and opioid dependence, who experienced post-traumatic stress disorder symptoms during a recent visit to the inpatient unit. The similarity of symptoms between post-traumatic stress disorder and opioid dependence is so high that, sometimes, it is a challenge to differentiate between these conditions...
September 3, 2017: Curēus
https://www.readbyqxmd.com/read/29141650/neuropsychological-function-is-improved-among-opioid-dependent-adults-who-adhere-to-opiate-agonist-treatment-with-buprenorphine-naloxone-a-preliminary-study
#12
Travis M Scott, Monica Rivera Mindt, Chinazo O Cunningham, Franchesca Arias, Kelly Coulehan, Aprille Mangalonzo, Pat Olsen, Julia H Arnsten
BACKGROUND: Among persons with opioid use disorder (OUD), neuropsychological dysfunction is associated with depression, and better neuropsychological function is associated with opioid abstinence. However, it is unknown whether depressive symptomatology or adherence to opiate agonist treatment are associated with neuropsychological change over time. METHODS: We recruited 20 buprenorphine/naloxone-treated adults with OUD (M Age = 45.2 years [SD = 8.1]; 25% female) to complete baseline and 6 month visits containing a neuropsychological test battery and self-reported measures of depressive symptomatology and medication adherence...
November 15, 2017: Substance Abuse Treatment, Prevention, and Policy
https://www.readbyqxmd.com/read/29140925/mobilization-of-cd4-t-lymphocytes-in-inflamed-mucosa-reduces-pain-in-colitis-mice-towards-a-vaccinal-strategy-to-alleviate-inflammatory-visceral-pain
#13
Lilian Basso, Jérôme Boué, Céline Augé, Céline Deraison, Catherine Blanpied, Nicolas Cenac, Philippe Lluel, Nathalie Vergnolle, Gilles Dietrich
T lymphocytes play a pivotal role in endogenous regulation of inflammatory visceral pain. The analgesic activity of T lymphocytes is dependent on their production of opioids, a property acquired upon antigen activation. Accordingly, we investigated whether an active recruitment of T lymphocytes within inflamed colon mucosa via a local vaccinal strategy may counteract inflammation-induced visceral pain in mice. Mice were immunized against ovalbumin (OVA). One month after immunization, colitis was induced by adding 3% (w/v) Dextran Sulfate Sodium (DSS) into drinking water containing either cognate antigen OVA or control antigen BSA for 5 days...
November 13, 2017: Pain
https://www.readbyqxmd.com/read/29140822/optimizing-pregnancy-treatment-interventions-for-moms-opti-mom-a-pilot-study
#14
Gerald T Cochran, Valerie Hruschak, Walitta Abdullah, Elizabeth Krans, Antoine B Douaihy, Stephanie Bobby, Rachel Fusco, Ralph Tarter
OBJECTIVES: The public health burden of opioid use disorder (OUD) among pregnant women has significantly increased in recent years. The Optimizing Pregnancy Treatment Interventions for Moms study was a pilot project that examined the feasibility of a patient navigation (PN) intervention model to reduce substance use and improve mental health, quality of life, and to increase engagement with treatment services among pregnant women with OUD. METHODS: A 1-group repeated-measures pilot study was conducted with treatment-seeking pregnant women with opioid dependence initiating buprenorphine maintenance treatment...
November 14, 2017: Journal of Addiction Medicine
https://www.readbyqxmd.com/read/29137427/association-of-opioid-receptor-mu-1-oprm1-a118g-polymorphism-rs1799971-with-nicotine-dependence
#15
Xiangyi Kong, Hao Deng, Theodore Alston, Yanguo Kong, Jingping Wang
Background and Object: Whether opioid-receptor mu 1 (OPRM1) A118G polymorphism (rs1799971) is associated with nicotine dependence is controversial. We analyzed the combined results from published studies of this possibility. Methods: Literature reviews were performed according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Web of Science, Chinese National Science Infrastructure (CNKI), PubMed, Embase and Google Scholar database searches using MeSH terms were conducted to find all relevant researches up to October 2016...
October 13, 2017: Oncotarget
https://www.readbyqxmd.com/read/29137290/expression-of-protein-kinase-a-and-the-kappa-opioid-receptor-in-selected-brain-regions-and-conditioned-place-aversion-in-morphine-dependent-rats
#16
Xiuhua Song, Wenqiang Li, Yuzhong Shi, Jingdan Zhang, Yi Li
This study examined adaptive changes in protein kinase A (PKA) and kappa opioid receptor (KOR) in selected addiction-related brain regions before and after conditioned place aversion (CPA). Seventy-two male SD rats were randomly assigned to an experimental group (morphine + naloxone, "MN") and 2 control groups: MS (morphine + saline) and SN (saline + naloxone). MN rats were intraperitoneally injected with morphine twice per day for 6.5 days and naloxone once and trained to establish CPA model. MS and SN rats were injected with equivalent volumes of morphine plus saline and saline plus naloxone, respectively...
October 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/29136566/treatment-for-opioid-use-and-outcomes-in-older-adults-a-systematic-literature-review
#17
REVIEW
Anne Marie Carew, Catherine Comiskey
BACKGROUND: Historically, issues relating to problem substance use among older people have received little attention, and have only recently been recognised. METHODS: A literature review of relevant material was conducted in November 2015 to assess current outcome research among older adults treated for opioid dependence. Multiple electronic databases were searched and results were supplemented by grey literature, library and online searches, and relevant references within selected articles...
November 7, 2017: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/29130600/opioid-dependence-and-pregnancy-in-early-twentieth-century-america
#18
Nathan Tauger
BACKGROUND AND AIMS: Research on Neonatal Abstinence Syndrome has prompted discussion over how to ensure best outcomes for pregnant women who use drugs and for drug-dependent newborns. Before Neonatal Abstinence Syndrome and the 1980s panic of "crack babies," turn-of-the-century American medical journals discussed infants born to drug-using mothers. This paper aimed to determine whether women who used drugs while pregnant in early twentieth-century America were subject to the stigma many face today...
November 11, 2017: Addiction
https://www.readbyqxmd.com/read/29127135/traditional-chinese-medicine-facilitated-treatments-may-relieve-anxiety-symptoms-during-drug-switching-from-methadone-to-buprenorphine-naloxone-for-treating-opioid-dependence
#19
Kai-Chiang Yu, Han-Ting Wei, Yuh-Hsiang Yeh, Chung-Hua Hsu
This study investigated a 51-year-old married man with a history of heroin dependence who underwent methadone maintenance treatment for 7 years. He received traditional Chinese medicine (TCM)-facilitated treatments and switched from methadone to buprenorphine/naloxone. Strong anxiety symptoms were observed during the initial stage; therefore, we prescribed a combination of Chaihu-Shugan-San, Zhi Bai Di Huang and Chin-Gin-Kuan-Ming decoction as the major herbal synergic regimen to relieve the symptoms of opioid withdrawal, anxiety and insomnia...
November 9, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/29126848/evaluation-of-external-vibratory-stimulation-as-a-treatment-for-chronic-scrotal-pain-in-adult-men-a-single-center-open-label-pilot-study
#20
Yash S Khandwala, Fernando Serrano, Michael L Eisenberg
BACKGROUND AND AIMS: Chronic scrotal pain is a common yet poorly understood urologic disease. Current treatment paradigms are sub-optimal and include anti-inflammatory drugs and opioids as well as invasive surgical management such as microdenervation of the spermatic cord. In this study, the efficacy of external vibratory stimulation (EVS) was evaluated as an alternative treatment option for idiopathic scrotal pain. MATERIALS AND METHODS: Ten consecutive patients presenting to an academic urology clinic between December 2016 and April 2017 with scrotal pain were prospectively enrolled...
November 7, 2017: Scandinavian Journal of Pain
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