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https://www.readbyqxmd.com/read/28431283/zika-virus-infection-of-adult-and-fetal-stat2-knock-out-hamsters
#1
Venkatraman Siddharthan, Arnaud J Van Wettere, Rong Li, Jinxin Miao, Zhongde Wang, John D Morrey, Justin G Julander
Zika virus (ZIKV) infection was investigated in adult and fetal STAT2 knock-out (KO) hamsters. Subcutaneous injection of ZIKV of adults resulted in morbidity, mortality, and infection of the uterus, placenta, brain, spinal cord, and testicles, thus providing an opportunity to evaluate congenital ZIKV infection in a second rodent species besides mice. ZIKV-infected cells with morphologies of Sertoli cells and spermatogonia were observed in the testes, which may have implications for sexual transmission and male sterility...
April 18, 2017: Virology
https://www.readbyqxmd.com/read/28431099/effect-of-cold-water-induced-stress-on-immune-response-pathology-and-fertility-in-mice-during-chlamydia-muridarum-genital-infection
#2
Tesfaye Belay, Anthony Woart, Vincent Graffeo
Genital infection by Chlamydia trachomatis (CT) is the most common bacterial sexually-transmitted disease worldwide. It causes serious reproductive health complications, including pelvic inflammatory disease and infertility. Stress is implicated as a risk factor for various infections; however, its effect on chlamydia genital infection is unknown. We previously showed that repeated exposure of mice to cold water results in increased severity of chlamydia genital infection. In the present study, cold water-induced stress resulted in: i) elevated levels of NE and EP in the spleen and genital tract of stressed mice; ii) elevated IL-1β, TNF-α, IL-6 and NO production in macrophage-rich peritoneal cells of mice; iii) supplement of NE in vitro exerts an immunosuppressive effect on splenic T cell production of cytokines; iv) decreased C...
April 18, 2017: Pathogens and Disease
https://www.readbyqxmd.com/read/28429951/-robotic-assisted-radical-prostatectomy-results-of-1500-surgeries
#3
J Kočárek, J Heráček, M Čermák, F Chmelík, M Matějková
INTRODUCTION: Prostate cancer is the most common malignant disease in men. The number of cases of prostate cancer has increased dramatically in recent 20 years. Radical prostatectomy is a surgical method for the first-line treatment of localised prostate cancer. We performed the first robotic-assisted radical prostatectomy on December 16th, 2005, achieved the boundary of 1000 robotic-assisted radical prostatectomies in 2012, and in 2015, we successfully completed the 1500th robotic-assisted operation on the prostate...
2017: Rozhledy V Chirurgii: Měsíčník Československé Chirurgické Společnosti
https://www.readbyqxmd.com/read/28429281/impact-of-thyroid-disease-on-testicular-function
#4
REVIEW
Sandro La Vignera, Roberto Vita, Rosita A Condorelli, Laura M Mongioì, Silvia Presti, Salvatore Benvenga, Aldo E Calogero
INTRODUCTION: Testis was considered unresponsive to thyroid hormone for a long time. However, like in animals, the presence of thyroid hormone receptors in different testicular cell types was demonstrated also in humans. Accordingly, thyrotoxicosis and hypothyroidism have remarkable effects on testicular function and more extensively on fertility. REVIEW: Thyrotoxicosis and hypothyroidism are associated with changes affecting the endocrine, sexual, or reproductive functions...
April 20, 2017: Endocrine
https://www.readbyqxmd.com/read/28428838/a-national-strategic-plan-for-reducing-the-burden-of-sexually-transmitted-infections-in-israel-by-the-year-2025
#5
Daniel Chemtob, Dan Gandacu, Zohar Mor, Itamar Grotto, Emilia Anis, Elliot Rosenberg
BACKGROUND: There is on ongoing debate in the literature regarding the real burden of STIs (sexually transmitted infections) in Western countries and the proper strategies needed to estimate and to prevent them. Our purpose is to present an evidence-based national strategic plan for STI prevention in Israel through assessing the current burden of illness, leading international preventive strategies, and practical policymaking experience. METHODS: Epidemiologic and health policy data on STIs were analyzed from various sources: a) systematic national surveillance data for the years 2002-2014; b) the international scientific literature (published between 2002-16; keywords: Sexually Transmitted Diseases (STD) (or STI) AND prevention AND intervention AND gonorrhea OR chlamydia OR syphilis; c) internal Ministry of Health (MOH) analyses and reports, and d) expert opinion...
2017: Israel Journal of Health Policy Research
https://www.readbyqxmd.com/read/28427723/health-related-quality-of-life-in-renal-transplantation-2-years-of-longitudinal-follow-up
#6
Gema Costa-Requena, M Carmen Cantarell, Francesc Moreso, Gemma Parramon, Daniel Seron
BACKGROUND AND OBJECTIVE: Health related quality of life (HRQoL) is recognized as an outcome measure in kidney transplantation. In this study was assessed changes on HRQoL and kidney-specific symptoms, also was evaluated the effect of socio-demographic and clinical parameters on patient's perceived HRQoL. PATIENTS AND METHOD: A longitudinal study was done, at 5 time-points over 2 years after transplantation. To evaluate HRQoL the Kidney Disease Quality of Life Questionnaire Short Form was administrated, and Hospital Anxiety and Depression Scale was used to assess psychological distress...
April 17, 2017: Medicina Clínica
https://www.readbyqxmd.com/read/28427697/health-care-disparities-stemming-from-sexual-orientation-of-italian-patients-with-multiple-sclerosis-a-cross-sectional-web-based-study
#7
Luigi Lavorgna, Marcello Moccia, Antonio Russo, Raffaele Palladino, Lucia Riccio, Roberta Lanzillo, Vincenzo Brescia Morra, Gioacchino Tedeschi, Simona Bonavita
Lesbian, gay, bisexual and transgender (LGBT) patients might experience unique difficulties and barriers to treatment of chronic diseases related to their sexual orientation. Thus, we investigated concerns experienced by LGBT patients with multiple sclerosis (MS). We conducted a web-based survey using a multi-choice questionnaire published in an Italian social-network (www.smsocialnetwork.com) for MS patients. The survey investigated: socio-demographic factors, lifestyle habits, MS-related health status and LGBT specific issues (e...
April 2017: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/28427542/recurrent-respiratory-papillomatosis-a-state-of-the-art-review
#8
REVIEW
Helena Ribeiro Fortes, Felipe Mussi von Ranke, Dante Luiz Escuissato, Cesar Augusto Araujo Neto, Gláucia Zanetti, Bruno Hochhegger, Carolina Althoff Souza, Edson Marchiori
Recurrent respiratory papillomatosis (RRP) is a benign disease of the upper aero-digestive tract caused by human papillomavirus (HPV) infection, which affects children and young adults. The aim of this review is to describe the main etiological, epidemiological, clinical, diagnostic, and treatment aspects of RRP. Most infections in children occur at birth, during passage through the birth canals of contaminated mothers. In adults, HPV is transmitted sexually. Papillomas usually appear as exophytic nodules, primarily in the larynx, but occasionally involving the nasopharynx, tracheobronchial tree, and pulmonary parenchyma...
May 2017: Respiratory Medicine
https://www.readbyqxmd.com/read/28426464/comparative-effectiveness-in-urology-a-state-of-the-art-review-utilizing-a-systematic-approach
#9
Jathin Bandari, Charles B Wessel, Bruce L Jacobs
PURPOSE OF REVIEW: Comparative effectiveness research plays a vital role in healthcare delivery by guiding evidence-based practices. We performed a state-of-the-art review of comparative effectiveness research in the urology literature for 2016, utilizing a systematic approach. Seven high-impact papers are reviewed in detail. RECENT FINDINGS: Across the breadth of urology, there were several important studies in comparative effectiveness research, of which we will highlight two randomized controlled trials and five observational trials: radiotherapy, prostatectomy, and active monitoring have equivalent mortality outcomes in patients with localized prostate cancer; the ideal modality of patient education is yet to be determined, and written education has minimal effect on patient perception of prostate specific antigen screening; robotic prostatectomy is associated with higher perioperative complication rates on a population basis; racial disparities exist in incontinence rates after treatment for localized prostate cancer, but not in irritative, bowel, or sexual function; androgen deprivation therapy is associated with higher fracture, peripheral artery disease, and cardiac-related complications than bilateral orchiectomy; robotic and open cystectomy offer comparable cancer-specific mortality and perioperative outcomes; and bonuses for low-cost hospitals can inadvertently reward low-quality hospitals...
April 19, 2017: Current Opinion in Urology
https://www.readbyqxmd.com/read/28426319/the-monetary-cost-of-sexual-assault-to-privately-insured-us-women-in-2013
#10
Ashley M Tennessee, Tamala S Bradham, Brandi M White, Kit N Simpson
OBJECTIVES: To determine whether privately insured female rape victims were billed for charges associated with a specific rape in the United States. METHODS: We examined 2013 de-identified patient data from Truven Analytics Health MarketScan database for an assault that occurred by using International Classification of Diseases, Ninth Revision, code E960.1. RESULTS: Analysis of insurance providers' payment patterns for 1355 incident events to female victims aged between 16 and 61 years revealed that victims remit, on average, 14% or $948 of the rape cost, whereas insurance providers pay 86% or $5789 of the total cost...
April 20, 2017: American Journal of Public Health
https://www.readbyqxmd.com/read/28426312/safe-sex-in-the-1970s-community-practitioners-on-the-eve-of-aids
#11
Thomas R Blair
In the 1970s, groups of gay and gay-allied health professionals began to formulate guidelines for safer sexual activity, several years before HIV/AIDS. Through such organizations as the National Coalition of Gay Sexually Transmitted Disease Services, Bay Area Physicians for Human Rights, and the Sisters of Perpetual Indulgence, these practitioners developed materials that would define sexual health education for the next four decades, as well as such concepts as "bodily fluids" and the "safe sex hanky." To do so, they used their dual membership in the community and the health professions...
April 20, 2017: American Journal of Public Health
https://www.readbyqxmd.com/read/28426114/infectious-diseases-and-migrant-worker-health-in-singapore-a-receiving-country-s-perspective
#12
Sapna P Sadarangani, Poh Lian Lim, Shawn Vasoo
Background.: Approximately 1.4 million migrant workers reside in Singapore, presenting unique infectious disease challenges to both migrants and Singapore. Methods.: A Pubmed, MEDLINE (Ovid), EBSCO Host (Global Health) and Google Scholar search was performed for both peer, non-peer reviewed articles and reports relevant to migrant health in Singapore, published between 1 January 1989 and 1 September 2016. Additional studies were identified from citations within searched articles...
July 1, 2017: Journal of Travel Medicine
https://www.readbyqxmd.com/read/28425904/-testing-is-healthy-timeplay-campaign-evaluation-of-sexual-health-promotion-gamification-intervention-targeting-young-adults
#13
Qinya Zhang, Kim J Huhn, Andy Tan, Rachel E Douglas, Helen Guiyun Li, Michelle Murti, Victoria Lee
OBJECTIVES: The objectives of the study were to 1) describe the implementation of the "Testing is Healthy" campaign in four locations in British Columbia (BC) and 2) report process evaluation indicators for the campaign. PARTICIPANTS: Young adults ages 20-29 years, the age group with the highest reported rates of chlamydia and gonorrhea in BC. SETTINGS: Movie theatres located in Langley, Burnaby, Coquitlam and Surrey, which are communities served by the Fraser Health Authority (FHA) in BC...
April 20, 2017: Canadian Journal of Public Health. Revue Canadienne de Santé Publique
https://www.readbyqxmd.com/read/28425301/development-of-a-novel-rationally-designed-antibiotic-to-inhibit-a-nontraditional-bacterial-target
#14
Pavel Dibrov, Elena Dibrov, Thane G Maddaford, Melissa Kenneth, Jordan Nelson, Craig Resch, Grant N Pierce
The search for new nontraditional targets is a high priority in antibiotic design today. Bacterial membrane energetics based on sodium ion circulation offers potential alternative targets. The present work identifies the Na(+)-translocating NADH:ubiquinone oxidoreductase (Na(+)-NQR), a key respiratory enzyme in many microbial pathogens, as indispensible for the Chlamydia trachomatis infectious process. Infection by Chlamydia trachomatis significantly increased first H(+) and then Na(+) levels within the host mammalian cell...
April 20, 2017: Canadian Journal of Physiology and Pharmacology
https://www.readbyqxmd.com/read/28425232/effect-of-familial-mediterranean-fever-on-sexual-and-reproductive-health-in-women
#15
Görkem Karakaş Uğurlu, Mustafa Uğurlu, Şükran Erten, Serdar Süleyman Can, Semra Ulusoy Kaymak, Ali Çayköylü
BACKGROUND/AIM: The aim of this study was to investigate the relationship between familial Mediterranean fever and female sexual dysfunction and premenstrual syndrome. MATERIALS AND METHODS: This study included 36 patients with familial Mediterranean fever and 33 healthy volunteers. Familial Mediterranean fever was diagnosed according to the Tel Hashomer criteria and familial Mediterranean fever mutations were identified in all of the patients. The patients and healthy volunteers were compared in terms of anxiety, depression, sexual dysfunction, and premenstrual syndrome, and a model was created that describes the relationships among these variables...
April 18, 2017: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/28424832/setting-up-a-community-based-cervical-screening-service-in-a-low-income-country-a-pilot-study-from-north-western-tanzania
#16
Nestory Masalu, Patrizia Serra, Dino Amadori, Jackson Kahima, Charles Majinge, Joyce Rwehabura, Oriana Nanni, Sara Bravaccini, Maurizio Puccetti, Rosario Tumino, Lauro Bucchi
OBJECTIVES: To report the results of a pilot study for a service for cervical cancer screening and diagnosis in north-western Tanzania. METHODS: The pilot study was launched in 2012 after a community-level information campaign. Women aged 15-64 years were encouraged to attend the district health centres. Attendees were offered a conventional Pap smear and a visual inspection of the cervix with acetic acid (VIA). RESULTS: The first 2500 women were evaluated...
April 19, 2017: International Journal of Public Health
https://www.readbyqxmd.com/read/28424504/prevalence-and-factors-associated-with-erectile-dysfunction-in-patients-with-chronic-kidney-disease-on-conservative-treatment
#17
M R Costa, V C Ponciano, T R Costa, A M de Oliveira, C P Gomes, E C de Oliveira
Population with chronic kidney disease (CKD) has had many problems, and some of these have arisen from sexual disorders. The present study intends to determine the prevalence and the associated factors with erectile dysfunction (ED) among patients with CKD on conservative treatment (CKDCT). This transversal study was conducted from May 2013 to December 2015. The tools used were: medical records and the International Index of Erectile Function. Data were analyzed by univariate and multivariate logistic regression analysis...
April 20, 2017: International Journal of Impotence Research
https://www.readbyqxmd.com/read/28424375/mitochondria-a-central-target-for-sex-differences-in-pathologies
#18
REVIEW
Renée Ventura-Clapier, Maryline Moulin, Jérôme Piquereau, Christophe Lemaire, Mathias Mericskay, Vladimir Veksler, Anne Garnier
It is increasingly acknowledged that a sex and gender specificity affects the occurrence, development, and consequence of a plethora of pathologies. Mitochondria are considered as the powerhouse of the cell because they produce the majority of energy-rich phosphate bonds in the form of adenosine tri-phosphate (ATP) but they also participate in many other functions like steroid hormone synthesis, reactive oxygen species (ROS) production, ionic regulation, and cell death. Adequate cellular energy supply and survival depend on mitochondrial life cycle, a process involving mitochondrial biogenesis, dynamics, and quality control via mitophagy...
May 1, 2017: Clinical Science (1979-)
https://www.readbyqxmd.com/read/28424280/the-major-envelope-glycoprotein-of-murid-herpesvirus-4-promotes-sexual-transmission
#19
Caroline Zeippen, Justine Javaux, Xue Xiao, Marina Ledecq, Jan Mast, Frédéric Farnir, Alain Vanderplasschen, Philip Stevenson, Laurent Gillet
Gammaherpesviruses are important human and animal pathogens. Infection control has proved difficult because the key process of transmission is ill-understood. Murid herpesvirus-4 (MuHV-4), a gammaherpesvirus of mice, transmits sexually. We show that this depends on the major virion envelope glycoprotein, gp150. Gp150 is redundant for host entry and, in vitro, it regulates rather than promotes cell binding. We show that gp150-deficient MuHV-4 reaches and replicates normally in the female genital tract after nasal infection, but is poorly released from vaginal epithelial cells and fails to pass from the female to the male genital tract during sexual contact...
April 19, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28423972/sexual-function-and-testosterone-level-in-men-with-conservatively-treated-chronic-kidney-disease
#20
Kerstin S Fugl-Meyer, Marie Nilsson, Britta Hylander, Mikael Lehtihet
Sexual dysfunctions are common, but underrecognized, in patients with chronic kidney disease (CKD) and are inversely associated with the glomerular filtration rate (GFR). Sexual dysfunctions may affect quality of life in males with CKD. The aim of this study was to analyze the relationship among sex hormones, sexual function, and sexual satisfaction in a group of men between 18 and 50 years of age with CKD Stages 1 to 5 not treated with hemodialysis or peritoneal dialysis. Fasting blood samples for hemoglobin, testosterone, prolactin, and luteinizing hormone and questionnaire surveys (Sexual Complaints Screener for Men, International Index of Erectile Function, and Aging Male Symptom scale) were evaluated in 100consecutive men...
April 1, 2017: American Journal of Men's Health
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