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Carlos pardo

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https://www.readbyqxmd.com/read/29667128/epigallocatechin-3-gallate-protects-and-prevents-paraquat-induced-oxidative-stress-and-neurodegeneration-in-knockdown-dj-1-%C3%AE-drosophila-melanogaster
#1
Daniel A Martinez-Perez, Marlene Jimenez-Del-Rio, Carlos Velez-Pardo
Epigallocatechin-3-gallate (EGCG) is a polyhydroxyphenol constituent of green tea (e.g., Camellia sinensis) with known antioxidant properties. Due to these properties, others have proposed it as a potential therapeutic agent for the treatment of Parkinson's disease (PD). Previously, we demonstrated that EGCG prolonged the lifespan and locomotor activity in wild-type Canton-S flies exposed to the neurotoxicant paraquat (PQ), suggesting neuroprotective properties. Both gene mutations and environmental neurotoxicants (e...
April 17, 2018: Neurotoxicity Research
https://www.readbyqxmd.com/read/29653023/%C3%AE-aminobutyric-acid-quantification-in-small-volume-biological-samples-through-enzymatically-induced-electrochemiluminescence
#2
Juan Carlos Salazar-Sánchez, Alberto Morales-Villagrán, Silvia Josefina López-Pérez, Kenia Pardo-Peña, Fridha Villalpando-Vargas, Laura Medina-Ceja
γ-Aminobutyric acid (GABA) is a well-known neurotransmitter that regulates inhibitory neurotransmission in the mammalian central nervous system and participates in several processes outside the brain. A reliable quantification method is needed to determine its role in different physiological and pathological conditions. However, GABA measurements have several challenges because GABA is neither fluorescent nor electroactive, and it is difficult to detect using enzymatic reactions because no oxidases or dehydrogenases have been identified...
April 13, 2018: Luminescence: the Journal of Biological and Chemical Luminescence
https://www.readbyqxmd.com/read/29625165/minocycline-induces-apoptosis-in-acute-lymphoblastic-leukemia-jurkat-cells
#3
Cristian Ruiz-Moreno, Carlos Velez-Pardo, Marlene Jimenez-Del-Rio
No abstract text is available yet for this article.
April 3, 2018: Toxicology in Vitro: An International Journal Published in Association with BIBRA
https://www.readbyqxmd.com/read/29569021/assessing-oral-health-related-quality-of-life-in-children-and-adolescents-a-systematic-review-and-standardized-comparison-of-available-instruments
#4
Carlos Zaror, Yolanda Pardo, Gerardo Espinoza-Espinoza, Àngels Pont, Patricia Muñoz-Millán, María José Martínez-Zapata, Gemma Vilagut, Carlos G Forero, Olatz Garin, Jordi Alonso, Montse Ferrer
OBJECTIVES: To obtain a systematic and standardized evaluation of the current evidence on development process, metric properties, and administration issues of oral health-related quality of life instruments available for children and adolescents. MATERIALS AND METHODS: A systematic search until October 2016 was conducted in PubMed, Embase, Lilacs, SciELO, and Cochrane databases. Articles with information regarding the development process, metric properties, and administration issues of pediatric instruments measuring oral health-related quality of life were eligible for inclusion...
March 22, 2018: Clinical Oral Investigations
https://www.readbyqxmd.com/read/29560574/correction-to-outcomes-after-distal-pancreatectomy-with-celiac-axis-resection-for-pancreatic-cancer-a-pan-european-retrospective-cohort-study
#5
Sjors Klompmaker, Jony van Hilst, Sarah L Gerritsen, Mustapha Adham, M Teresa Albiol Quer, Claudio Bassi, Frederik Berrevoet, Ugo Boggi, Olivier R Busch, Manuela Cesaretti, Raffaele Dalla Valle, Benjamin Darnis, Matteo De Pastena, Marco Del Chiaro, Robert Grützmann, Markus K Diener, Traian Dumitrascu, Helmut Friess, Arpad Ivanecz, Anastasios Karayiannakis, Giuseppe K Fusai, Knut J Labori, Carlo Lombardo, Santiago López-Ben, Jean-Yves Mabrut, Willem Niesen, Fernando Pardo, Julie Perinel, Irinel Popescu, Geert Roeyen, Alain Sauvanet, Raj Prasad, Christian Sturesson, Mickael Lesurtel, Jorg Kleeff, Roberto Salvia, Marc G Besselink
In the original article, the institutional author the E-AHPBA DP-CAR study group was misspelled. It is correct as reflected here. The original article has also been corrected.
March 20, 2018: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/29532342/outcomes-after-distal-pancreatectomy-with-celiac-axis-resection-for-pancreatic-cancer-a-pan-european-retrospective-cohort-study
#6
Sjors Klompmaker, Jony van Hilst, Sarah L Gerritsen, Mustapha Adham, M Teresa Albiol Quer, Claudio Bassi, Frederik Berrevoet, Ugo Boggi, Olivier R Busch, Manuela Cesaretti, Raffaele Dalla Valle, Benjamin Darnis, Matteo De Pastena, Marco Del Chiaro, Robert Grützmann, Markus K Diener, Traian Dumitrascu, Helmut Friess, Arpad Ivanecz, Anastasios Karayiannakis, Giuseppe K Fusai, Knut J Labori, Carlo Lombardo, Santiago López-Ben, Jean-Yves Mabrut, Willem Niesen, Fernando Pardo, Julie Perinel, Irinel Popescu, Geert Roeyen, Alain Sauvanet, Raj Prasad, Christian Sturesson, Mickael Lesurtel, Jorg Kleeff, Roberto Salvia, Marc G Besselink
BACKGROUND: Western multicenter studies on distal pancreatectomy with celiac axis resection (DP-CAR), also known as the Appleby procedure, for locally advanced pancreatic cancer are lacking. We aimed to study overall survival, morbidity, mortality and the impact of preoperative hepatic artery embolization (PHAE). METHODS: Retrospective cohort study within the European-African Hepato-Pancreato-Biliary-Association, on DP-CAR between 1-1-2000 and 6-1-2016. Primary endpoint was overall survival...
March 12, 2018: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/29530988/deletion-of-the-cold-thermoreceptor-trpm8-increases-heat-loss-and-food-intake-leading-to-reduced-body-temperature-and-obesity-in-mice
#7
Alfonso Reimúndez, Carlos Fernández-Peña, Guillermo García, Rubén Fernández, Purificación Ordás, Rosalía Gallego, José L Pardo-Vazquez, Victor Arce, Félix Viana, Rosa Señarís
The coupling of energy homeostasis to thermoregulation is essential to maintain homeothermy in changing external environments. We studied the role of the cold thermoreceptor TRPM8 in this interplay in mice of both sexes. We demonstrate that TRPM8 is required for a precise thermoregulation in response to cold, in fed and fasting. Trpm8-/- mice exhibited a fall of 0.7 °C in core body temperature (Tc) when housed at cold temperatures, and a deep hypothermia (below 30 °C) during food deprivation. In both situations TRPM8-deficiency induced an increase in tail heat loss...
March 12, 2018: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/29496420/current-status-of-multidisciplinary-care-in-psoriatic-arthritis-in-spain-nexus-2-0-project
#8
Rubén Queiro, Pablo Coto, Beatriz Joven, Raquel Rivera, Teresa Navío Marco, Pablo de la Cueva, Jose Luis Alvarez Vega, Basilio Narváez Moreno, Fernando José Rodriguez Martínez, José Pardo Sánchez, Carlos Feced Olmos, Conrad Pujol, Jesús Rodríguez, Jaume Notario, Manel Pujol Busquets, Mercè García Font, Eva Galindez, Silvia Pérez Barrio, Ana Urruticoechea-Arana, Merce Hergueta, M Dolores López Montilla, Antonio Vélez García-Nieto, Francisco Maceiras, Laura Rodríguez Pazos, Esteban Rubio Romero, Lourdes Rodríguez Fernandez Freire, Jesús Luelmo, Jordi Gratacós
OBJECTIVE: 1) To analyze the implementation of multidisciplinary care models in psoriatic arthritis (PsA) patients, 2) To define minimum and excellent standards of care. METHODS: A survey was sent to clinicians who already performed multidisciplinary care or were in the process of undertaking it, asking: 1) Type of multidisciplinary care model implemented; 2) Degree, priority and feasibility of the implementation of quality standards in the structure, process and result for care...
February 26, 2018: Reumatología Clinica
https://www.readbyqxmd.com/read/29488994/enantioselective-synthesis-of-chiral-oxazolines-from-unactivated-ketones-and-isocyanoacetate-esters-by-synergistic-silver-organocatalysis
#9
Pablo Martínez-Pardo, Gonzalo Blay, M Carmen Muñoz, José R Pedro, Amparo Sanz-Marco, Carlos Vila
A multicatalytic approach that combines a bifunctional Brønsted base-squaramide organocatalyst and Ag+ as Lewis acid has been applied in the reaction of unactivated ketones with tert-butyl isocyanoacetate to give chiral oxazolines bearing a quaternary stereocenter. The formal [3+2] cycloaddition provided high yields of the corresponding cis-oxazolines with good diastereoselectivity and excellent enantioselectivity, being applied to aryl-alkyl and alkyl-alkyl ketones.
February 28, 2018: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/29473047/familial-monophasic-acute-transverse-myelitis-due-to-the-pathogenic-variant-in-vps37a
#10
Maureen A Mealy, Tai-Seung Nam, Santiago J Pardo, Carlos A Pardo, Nara L Sobreira, Dimitrios Avramopoulos, David Valle, Kathleen H Burns, Michael Levy
Objective: To identify genetic differences among siblings with a family history of idiopathic transverse myelitis (ITM). Methods: We compared whole-exome sequencing (WES) on germline samples from the 2 affected sisters with ITM with 3 of their healthy siblings. Results: The 2 sisters with ITM both had acute onset of sensory loss in the legs, weakness, and bowel/bladder dysfunction. The first developed ITM at age 15 years with a clinical nadir of complete paralysis, which slowly recovered over a few years...
February 2018: Neurology. Genetics
https://www.readbyqxmd.com/read/29432180/piezo2-channel-regulates-rhoa-and-actin-cytoskeleton-to-promote-cell-mechanobiological-responses
#11
Carlos Pardo-Pastor, Fanny Rubio-Moscardo, Marina Vogel-González, Selma A Serra, Alexandros Afthinos, Sanela Mrkonjic, Olivier Destaing, Juan F Abenza, José M Fernández-Fernández, Xavier Trepat, Corinne Albiges-Rizo, Konstantinos Konstantopoulos, Miguel A Valverde
Actin polymerization and assembly into stress fibers (SFs) is central to many cellular processes. However, how SFs form in response to the mechanical interaction of cells with their environment is not fully understood. Here we have identified Piezo2 mechanosensitive cationic channel as a transducer of environmental physical cues into mechanobiological responses. Piezo2 is needed by brain metastatic cells from breast cancer (MDA-MB-231-BrM2) to probe their physical environment as they anchor and pull on their surroundings or when confronted with confined migration through narrow pores...
February 5, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29428530/rotenone-exerts-developmental-neurotoxicity-in-a-human-brain-spheroid-model
#12
David Pamies, Katharina Block, Pierre Lau, Laura Gribaldo, Carlos Pardo, Paula Barreras, Lena Smirnova, Daphne Wiersma, Liang Zhao, Georgina Harris, Thomas Hartung, Helena T Hogberg
Growing concern suggests that some chemicals exert (developmental) neurotoxicity (DNT and NT) and are linked to the increase in incidence of autism, attention deficit and hyperactivity disorders. The high cost of routine tests for DNT and neurotoxicity (NT) assessment make it difficult to test the high numbers of existing chemicals. Thus, more cost effective neurodevelopmental models are needed. The use of induced pluripotent stem cells (iPSC) in combination with the emerging human 3D tissue culture platforms, present a novel tool to predicting and study human toxicity...
February 8, 2018: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/29417210/standards-of-care-and-quality-indicators-for-multidisciplinary-care-models-for-psoriatic-arthritis-in-spain
#13
Jordi Gratacós, Jesús Luelmo, Jesús Rodríguez, Jaume Notario, Teresa Navío Marco, Pablo de la Cueva, Manel Pujol Busquets, Mercè García Font, Beatriz Joven, Raquel Rivera, Jose Luis Alvarez Vega, Antonio Javier Chaves Álvarez, Ricardo Sánchez Parera, Jose Carlos Ruiz Carrascosa, Fernando José Rodríguez Martínez, José Pardo Sánchez, Carlos Feced Olmos, Conrad Pujol, Eva Galindez, Silvia Pérez Barrio, Ana Urruticoechea Arana, Mercedes Hergueta, Pablo Coto, Rubén Queiro
To define and give priority to standards of care and quality indicators of multidisciplinary care for patients with psoriatic arthritis (PsA). A systematic literature review on PsA standards of care and quality indicators was performed. An expert panel of rheumatologists and dermatologists who provide multidisciplinary care was established. In a consensus meeting group, the experts discussed and developed the standards of care and quality indicators and graded their priority, agreement and also the feasibility (only for quality indicators) following qualitative methodology and a Delphi process...
February 7, 2018: Rheumatology International
https://www.readbyqxmd.com/read/29367946/erratum-variable-frequency-of-lrrk2-variants-in-the-latin-american-research-consortium-on-the-genetics-of-parkinson-s-disease-large-pd-a-case-of-ancestry
#14
Mario Cornejo-Olivas, Luis Torres, Mario R Velit-Salazar, Miguel Inca-Martinez, Pilar Mazzetti, Carlos Cosentino, Federico Micheli, Claudia Perandones, Elena Dieguez, Victor Raggio, Vitor Tumas, Vanderci Borges, Henrique B Ferraz, Carlos R M Rieder, Artur Shumacher-Schuh, Carlos Velez-Pardo, Marlene Jimenez-Del-Rio, Francisco Lopera, Jorge Chang-Castello, Brennie Andreé-Munoz, Sarah Waldherr, Dora Yearout, Cyrus P Zabetian, Ignacio F Mata
[This corrects the article DOI: 10.1038/s41531-017-0020-6.].
2018: NPJ Parkinson's Disease
https://www.readbyqxmd.com/read/29336753/randomized-clinical-trial-comparing-low-density-versus-high-density-meshes-in-patients-with-bilateral-inguinal-hernia
#15
RANDOMIZED CONTROLLED TRIAL
Jose Luis Porrero Carro, Sol Villar Riu, Beatriz Ramos Lojo, Lucia Latorre, Maria Teresa Alonso Garcia, Benito Alcaide Pardo, Oscar Bonachia Naranjo, Alberto Marcos Herrero, Carlos Sanchez Cabezudo, Esther Quiros Herreras
We present a randomized clinical trial to compare postoperative pain, complications, feeling of a foreign body, and recurrence between heavyweight and lightweight meshes in patients with bilateral groin hernia. Sixty-seven patients with bilateral hernia were included in our study. In each patient, the side of the lightweight mesh was decided by random numbers table. Pain score was measured by visual analogue scale, on 1st, 3rd, 5th, and 7th postoperative day, and one year after the surgery. There were no statistically significative differences between both meshes in postoperative complications...
December 1, 2017: American Surgeon
https://www.readbyqxmd.com/read/29298841/galectin-8-induces-partial-epithelial-mesenchymal-transition-with-invasive-tumorigenic-capabilities-involving-a-fak-egfr-proteasome-pathway-in-madin-darby-canine-kidney-cells
#16
Claudia Oyanadel, Christopher Holmes, Evelyn Pardo, Claudio Retamal, Ronan Shaughnessy, Patricio Smith, Priscilla Cortés, Marcela Bravo-Zehnder, Claudia Metz, Teo Feuerhake, Diego Romero, Juan Carlos Roa, Viviana Montecinos, Andrea Soza, Alfonso González
Epithelial cells can acquire invasive and tumorigenic capabilities through epithelial-mesenchymal-transition (EMT). The glycan-binding protein galectin-8 (Gal-8) activates selective β1-integrins involved in EMT and is overexpressed by certain carcinomas. Here we show that Gal-8 overexpression or exogenous addition promotes proliferation, migration, and invasion in nontumoral Madin-Darby canine kidney (MDCK) cells, involving focal-adhesion kinase (FAK)-mediated transactivation of the epidermal growth factor receptor (EGFR), likely triggered by α5β1integrin binding...
March 1, 2018: Molecular Biology of the Cell
https://www.readbyqxmd.com/read/29281496/study-of-the-occurrence-and-ecosystem-danger-of-selected-endocrine-disruptors-in-the-urban-water-cycle-of-the-city-of-bogot%C3%A3-colombia
#17
Diego F Bedoya-Ríos, Jaime A Lara-Borrero, Verónica Duque-Pardo, Carlos A Madera-Parra, Eliana M Jimenez, Andrés F Toro
Endocrine disruptors have been studied for their high occurrence in different environments including aquatic; however, in the context of developing countries, their occurrence, magnitude and potential threat have little information. This study involved the analysis of various components of the urban water cycle in the city of Bogotá, Colombia. As a result, it was found that the compounds with the highest occurrence are plasticizers such as phthalates and bisphenol A, whereas among the drugs, carbamazepine presented the highest concentrations (0...
March 21, 2018: Journal of Environmental Science and Health. Part A, Toxic/hazardous Substances & Environmental Engineering
https://www.readbyqxmd.com/read/29278331/methodology-for-the-absolute-configuration-determination-of-epoxythymols-using-the-constituents-of-ageratina-glabrata
#18
Héctor M Arreaga-González, Julio C Pardo-Novoa, Rosa E Del Río, Gabriela Rodríguez-García, J Martín Torres-Valencia, J Jesús Manríquez-Torres, Carlos M Cerda-García-Rojas, Pedro Joseph-Nathan, Mario A Gómez-Hurtado
A methodology to determine the enantiomeric excess and the absolute configuration (AC) of natural epoxythymols was developed and tested using five constituents of Ageratina glabrata. The methodology is based on enantiomeric purity determination employing 1,1'-bi-2-naphthol (BINOL) as a chiral solvating agent combined with vibrational circular dichroism (VCD) measurements and calculations. The conformational searching included an extensive Monte Carlo protocol that considered the rotational barriers to cover the whole conformational spaces...
January 26, 2018: Journal of Natural Products
https://www.readbyqxmd.com/read/29245899/constitutive-cyclin-o-deficiency-results-in-penetrant-hydrocephalus-impaired-growth-and-infertility
#19
Marc Núnez-Ollé, Carole Jung, Berta Terré, Norman A Balsiger, Cristina Plata, Ramon Roset, Carlos Pardo-Pastor, Marta Garrido, Santiago Rojas, Francesc Alameda, Josep Lloreta, Juan Martín-Caballero, Juana M Flores, Travis H Stracker, Miguel A Valverde, Francisco J Muñoz, Gabriel Gil-Gómez
Cyclin O (encoded by CCNO ) is a member of the cyclin family with regulatory functions in ciliogenesis and apoptosis. Homozygous CCNO mutations have been identified in human patients with Reduced Generation of Multiple Motile Cilia (RGMC) and conditional inactivation of Ccno in the mouse recapitulates some of the pathologies associated with the human disease. These include defects in the development of motile cilia and hydrocephalus. To further investigate the functions of Ccno in vivo , we have generated a new mouse model characterized by the constitutive loss of Ccno in all tissues and followed a cohort during ageing...
November 21, 2017: Oncotarget
https://www.readbyqxmd.com/read/29243554/parametric-estimates-for-the-receiver-operating-characteristic-curve-generalization-for-non-monotone-relationships
#20
Pablo Martínez-Camblor, Juan C Pardo-Fernández
Diagnostic procedures are based on establishing certain conditions and then checking if those conditions are satisfied by a given individual. When the diagnostic procedure is based on a continuous marker, this is equivalent to fix a region or classification subset and then check if the observed value of the marker belongs to that region. Receiver operating characteristic curve is a valuable and popular tool to study and compare the diagnostic ability of a given marker. Besides, the area under the receiver operating characteristic curve is frequently used as an index of the global discrimination ability...
January 1, 2017: Statistical Methods in Medical Research
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