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Norman haughey

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https://www.readbyqxmd.com/read/28598843/a-lipidomics-approach-to-assess-the%C3%A2-association-between-plasma-sphingolipids-and-verbal-memory-performance-in-coronary-artery-disease-patients-undertaking-cardiac-rehabilitation-a-c18-0-signature-for%C3%A2-cognitive-response-to-exercise
#1
Mahwesh Saleem, Nathan Herrmann, Adam Dinoff, Michelle M Mielke, Paul I Oh, Prathiba Shammi, Xingshan Cao, Swarajya Lakshmi Vattem Venkata, Norman J Haughey, Krista L Lanctôt
BACKGROUND: Early subtle deficits in verbal memory, which may indicate early neural risk, are common in patients with coronary artery disease (CAD). While exercise can improve cognition, cognitive response to exercise is heterogeneous. Sphingolipids have been associated with the development and progression of CAD, and impairments in sphingolipid metabolism may play roles in neurodegeneration and in the neural adaptation response to exercise. OBJECTIVE: In this study, change in plasma concentrations of sphingolipids was assessed in relation to change in verbal memory performance and in other cognitive domains among CAD subjects undertaking a 6-month cardiac rehabilitation (CR) program...
June 3, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28574961/modifications-in-acute-phase-and-complement-systems-predict-shifts-in-cognitive-status-of-hiv-infected-patients
#2
Ceereena Ubaida-Mohien, Benjamin Lamberty, Alex M Dickens, Michelle M Mielke, Thomas Marcotte, Ned Sacktor, Igor Grant, Scott Letendre, Donald Franklin, Pawel Cibrowski, Ravi Tharakan, Justin C McArthur, Howard Fox, Norman J Haughey
BACKGROUND: The prevalence of HIV-associated neurocognitive disorders (HAND) has not changed considerably in the last two decades. Potent antiretroviral therapy has shifted the severity of HAND to milder phenotypes, but excess morbidity and mortality continue to be associated with HAND. Changes in numerous markers of immune function, inflammation, and cellular stress have been repeatedly associated with HAND, but the underlying systems that drive these changes have not been identified...
June 19, 2017: AIDS
https://www.readbyqxmd.com/read/28537385/the-psychiatric-impact-of-hiv
#3
Michael T Nedelcovych, Arena A Manning, Svetlana Semenova, Charlene Gamaldo, Norman J Haughey, Barbara S Slusher
This Viewpoint is based on a recent panel featured at the 2017 Winter Conference on Brain Research in which the psychiatric comorbidities of HIV infection were discussed. Psychiatric comorbid conditions occur at high rates in HIV infected patients, complicating treatment and contributing to poor outcomes. A complex relationship between HIV infection and psychiatric comorbidity is an active area of investigation, but increased awareness of the impact of psychiatric complications of NeuroAIDS is needed in both the laboratory and the clinic to better understand and treat these interrelated conditions...
May 24, 2017: ACS Chemical Neuroscience
https://www.readbyqxmd.com/read/28486481/temporal-changes-in-sphingolipids-and-systemic-insulin-sensitivity-during-the-transition-from-gestation-to-lactation
#4
J Eduardo Rico, Sina Saed Samii, Alice T Mathews, Jacqueline Lovett, Norman J Haughey, Joseph W McFadden
Reduced insulin action develops naturally during the peripartum to ensure maternal nutrient delivery to the fetus and neonate. However, increased insulin resistance can facilitate excessive lipolysis which in turn promotes metabolic disease in overweight dairy cattle. Increased fatty acid availability favors the accumulation of the sphingolipid ceramide and is implicated in the pathogenesis of insulin resistance, however, the relationship between sphingolipid metabolism and insulin resistance during the peripartum remains largely unknown...
2017: PloS One
https://www.readbyqxmd.com/read/28398956/informatic-interrogation-of-csf-proteomic-profiles-from-hiv-infected-subjects-implicates-acute-phase-and-complement-systems-in-shifting-cognitive-status
#5
Ceereena Ubaida-Mohien, Benjamin Lamberty, Alex M Dickens, Michelle M Mielke, Thomas Marcotte, Ned Sacktor, Igor Grant, Scott Letendre, D Franklin, Pawel Cibrowski, Ravi Tharakan, Justin C McArthur, Howard Fox, Norman J Haughey
The prevalence of HIV-Associated Neurocognitive Disorders (HAND) has not changed considerably in the last two decades. Potent antiretroviral therapy (ART) has shifted the severity of HAND to milder phenotypes, but excess morbidity and mortality continue to be associated with HAND. Changes in numerous markers of immune function, inflammation and cellular stress have been repeatedly associated with HAND but the underlying systems that drive these changes have not been identified. In this study we used systems informatics to interrogate the CSF proteomic content of longitudinal samples obtained from HIV-infected adults with stably unimpaired, stably impaired, worsening, or improving neurocognitive (NC) performance...
April 10, 2017: AIDS
https://www.readbyqxmd.com/read/28377412/astrocyte-shed-extracellular-vesicles-regulate-the-peripheral-leukocyte-response-to-inflammatory-brain-lesions
#6
Alex M Dickens, Luis B Tovar-Y-Romo, Seung-Wan Yoo, Amanda L Trout, Mihyun Bae, Marlene Kanmogne, Bezawit Megra, Dionna W Williams, Kennith W Witwer, Mar Gacias, Nino Tabatadze, Robert N Cole, Patrizia Casaccia, Joan W Berman, Daniel C Anthony, Norman J Haughey
Brain injury induces a peripheral acute cytokine response that directs the transmigration of leukocytes into the brain. Because this brain-to-peripheral immune communication affects patient recovery, understanding its regulation is important. Using a mouse model of inflammatory brain injury, we set out to find a soluble mediator for this phenomenon. We found that extracellular vesicles (EVs) shed from astrocytes in response to intracerebral injection of interleukin-1β (IL-1β) rapidly entered into peripheral circulation and promoted the transmigration of leukocytes through modulation of the peripheral acute cytokine response...
April 4, 2017: Science Signaling
https://www.readbyqxmd.com/read/28218748/hiv-tat-protein-and-amyloid-%C3%AE-peptide-form-multifibrillar-structures-that-cause-neurotoxicity
#7
Alina Hategan, Mario A Bianchet, Joseph Steiner, Elena Karnaukhova, Eliezer Masliah, Adam Fields, Myoung-Hwa Lee, Alex M Dickens, Norman Haughey, Emilios K Dimitriadis, Avindra Nath
Deposition of amyloid-β plaques is increased in the brains of HIV-infected individuals, and the HIV transactivator of transcription (Tat) protein affects amyloidogenesis through several indirect mechanisms. Here, we investigated direct interactions between Tat and amyloid-β peptide. Our in vitro studies showed that in the presence of Tat, uniform amyloid fibrils become double twisted fibrils and further form populations of thick unstructured filaments and aggregates. Specifically, Tat binding to the exterior surfaces of the Aβ fibrils increases β-sheet formation and lateral aggregation into thick multifibrillar structures, thus producing fibers with increased rigidity and mechanical resistance...
April 2017: Nature Structural & Molecular Biology
https://www.readbyqxmd.com/read/28035934/the-association-between-plasma-ceramides-and-sphingomyelins-and-risk-of-alzheimer-s-disease-differs-by-sex-and-apoe-in-the-baltimore-longitudinal-study-of-aging
#8
Michelle M Mielke, Norman J Haughey, Dingfen Han, Yang An, Veera Venkata Ratnam Bandaru, Constantine G Lyketsos, Luigi Ferrucci, Susan M Resnick
BACKGROUND: Cellular and animal studies demonstrated relationships between sphingolipid metabolism and Alzheimer's disease (AD) pathology. High blood ceramide levels have been shown to predict cognitive impairment and AD, but these studies had small sample sizes and did not assess differences in risk by sex or APOE genotype. OBJECTIVE: To determine whether plasma ceramides and sphingomyelins were associated with risk of AD, and whether the association varied by sex and APOE genotype...
December 30, 2016: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/27993242/hiv-protease-inhibitors-alter-amyloid-precursor-protein-processing-via-%C3%AE-site-amyloid-precursor-protein-cleaving-enzyme-1-translational-up-regulation
#9
Patrick J Gannon, Cagla Akay-Espinoza, Alan C Yee, Lisa A Briand, Michelle A Erickson, Benjamin B Gelman, Yan Gao, Norman J Haughey, M Christine Zink, Janice E Clements, Nicholas S Kim, Gabriel Van De Walle, Brigid K Jensen, Robert Vassar, R Christopher Pierce, Alexander J Gill, Dennis L Kolson, J Alan Diehl, Joseph L Mankowski, Kelly L Jordan-Sciutto
Mounting evidence implicates antiretroviral (ARV) drugs as potential contributors to the persistence and evolution of clinical and pathological presentation of HIV-associated neurocognitive disorders in the post-ARV era. Based on their ability to induce endoplasmic reticulum (ER) stress in various cell types, we hypothesized that ARV-mediated ER stress in the central nervous system resulted in chronic dysregulation of the unfolded protein response and altered amyloid precursor protein (APP) processing. We used in vitro and in vivo models to show that HIV protease inhibitor (PI) class ARVs induced neuronal damage and ER stress, leading to PKR-like ER kinase-dependent phosphorylation of the eukaryotic translation initiation factor 2α and enhanced translation of β-site APP cleaving enzyme-1 (BACE1)...
January 2017: American Journal of Pathology
https://www.readbyqxmd.com/read/27379802/humoral-dysregulation-associated-with-increased-systemic-inflammation-among-injection-heroin-users
#10
Michael S Piepenbrink, Memorie Samuel, Bo Zheng, Brittany Carter, Christopher Fucile, Catherine Bunce, Michelle Kiebala, Atif A Khan, Juilee Thakar, Sanjay B Maggirwar, Diane Morse, Alexander F Rosenberg, Norman J Haughey, William Valenti, Michael C Keefer, James J Kobie
BACKGROUND: Injection drug use is a growing major public health concern. Injection drug users (IDUs) have a higher incidence of co-morbidities including HIV, Hepatitis, and other infections. An effective humoral response is critical for optimal homeostasis and protection from infection; however, the impact of injection heroin use on humoral immunity is poorly understood. We hypothesized that IDUs have altered B cell and antibody profiles. METHODS AND FINDINGS: A comprehensive systems biology-based cross-sectional assessment of 130 peripheral blood B cell flow cytometry- and plasma- based features was performed on HIV-/Hepatitis C-, active heroin IDUs who participated in a syringe exchange program (n = 19) and healthy control subjects (n = 19)...
2016: PloS One
https://www.readbyqxmd.com/read/27255825/peripheral-sphingolipids-are-associated-with-variation-in-white-matter-microstructure-in-older-adults
#11
Christopher E Gonzalez, Vijay K Venkatraman, Yang An, Bennett A Landman, Christos Davatzikos, Veera Venkata Ratnam Bandaru, Norman J Haughey, Luigi Ferrucci, Michelle M Mielke, Susan M Resnick
Sphingolipids serve important structural and functional roles in cellular membranes and myelin sheaths. Plasma sphingolipids have been shown to predict cognitive decline and Alzheimer's disease. However, the association between plasma sphingolipid levels and brain white matter (WM) microstructure has not been examined. We investigated whether plasma sphingolipids (ceramides and sphingomyelins) were associated with magnetic resonance imaging-based diffusion measures, fractional anisotropy (FA), and mean diffusivity, 10...
July 2016: Neurobiology of Aging
https://www.readbyqxmd.com/read/27135629/circulating-ceramides-are-inversely-associated-with-cardiorespiratory-fitness-in-participants-aged-54-96%C3%A2-years-from-the-baltimore-longitudinal-study-of-aging
#12
Elisa Fabbri, An Yang, Eleanor M Simonsick, Chee W Chia, Marco Zoli, Norman J Haughey, Michelle M Mielke, Luigi Ferrucci, Paul M Coen
Cardiorespiratory fitness (VO2 peak) declines with age and is an independent risk factor for morbidity and mortality in older adults. Identifying biomarkers of low fitness may provide insight for why some individuals experience an accelerated decline of aerobic capacity and may serve as clinically valuable prognostic indicators of cardiovascular health. We investigated the relationship between circulating ceramides and VO2 peak in 443 men and women (mean age of 69) enrolled in the Baltimore Longitudinal Study of Aging (BLSA)...
October 2016: Aging Cell
https://www.readbyqxmd.com/read/27083773/connexin-43-in-astrocytes-contributes-to-motor-neuron-toxicity-in-amyotrophic-lateral-sclerosis
#13
Akshata A Almad, Arpitha Doreswamy, Sarah K Gross, Jean-Philippe Richard, Yuqing Huo, Norman Haughey, Nicholas J Maragakis
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by progressive loss of motor neurons in the CNS. Astrocytes play a critical role in disease progression of ALS. Astrocytes are interconnected through a family of gap junction proteins known as connexins (Cx). Cx43 is a major astrocyte connexin conducting crucial homeostatic functions in the CNS. Under pathological conditions, connexin expression and functions are altered. Here we report that an abnormal increase in Cx43 expression serves as one of the mechanisms for astrocyte-mediated toxicity in ALS...
July 2016: Glia
https://www.readbyqxmd.com/read/27080521/hiv-associated-neurocognitive-disorder-pathogenesis-and-prospects-for-treatment
#14
Deanna Saylor, Alex M Dickens, Ned Sacktor, Norman Haughey, Barbara Slusher, Mikhail Pletnikov, Joseph L Mankowski, Amanda Brown, David J Volsky, Justin C McArthur
No abstract text is available yet for this article.
May 2016: Nature Reviews. Neurology
https://www.readbyqxmd.com/read/26965674/hiv-associated-neurocognitive-disorder-pathogenesis-and-prospects-for-treatment
#15
REVIEW
Deanna Saylor, Alex M Dickens, Ned Sacktor, Norman Haughey, Barbara Slusher, Mikhail Pletnikov, Joseph L Mankowski, Amanda Brown, David J Volsky, Justin C McArthur
In the past two decades, several advancements have improved the care of HIV-infected individuals. Most importantly, the development and deployment of combination antiretroviral therapy (CART) has resulted in a dramatic decline in the rate of deaths from AIDS, so that people living with HIV today have nearly normal life expectancies if treated with CART. The term HIV-associated neurocognitive disorder (HAND) has been used to describe the spectrum of neurocognitive dysfunction associated with HIV infection. HIV can enter the CNS during early stages of infection, and persistent CNS HIV infection and inflammation probably contribute to the development of HAND...
April 2016: Nature Reviews. Neurology
https://www.readbyqxmd.com/read/26692391/erratum-to-interaction-of-paroxetine-with-mitochondrial-proteins-mediates-neuroprotection
#16
Joseph P Steiner, Muznabanu Bachani, Brett Wolfson-Stofko, Myoung-Hwa Lee, Tongguang Wang, Guanhan Li, Wenxue Li, David Strayer, Norman J Haughey, Avindra Nath
No abstract text is available yet for this article.
January 2016: Neurotherapeutics: the Journal of the American Society for Experimental NeuroTherapeutics
https://www.readbyqxmd.com/read/26354990/interictal-circulating-sphingolipids-in-women-with-episodic-migraine-a-case-control-study
#17
B Lee Peterlin, Michelle M Mielke, Alex M Dickens, Subroto Chatterjee, Paul Dash, Guillermo Alexander, Rebeca V A Vieira, Veera Venkata Ratnam Bandaru, Joelle M Dorskind, Gretchen E Tietjen, Norman H Haughey
OBJECTIVE: To evaluate interictal, circulating sphingolipids in women migraineurs. METHODS: In the fasting state, serum samples were obtained pain-free from 88 women with episodic migraine (EM; n=52) and from controls (n=36). Sphingolipids were detected and quantified by high-performance liquid chromatography coupled with tandem mass spectrometry using multiple reaction monitoring. Multivariate logistic regression was used to examine the association between serum sphingolipids and EM odds...
October 6, 2015: Neurology
https://www.readbyqxmd.com/read/26193443/demographic-and-clinical-variables-affecting-mid-to-late-life-trajectories-of-plasma-ceramide-and-dihydroceramide-species
#18
Michelle M Mielke, Veera Venkata Ratnam Bandaru, Dingfen Han, Yang An, Susan M Resnick, Luigi Ferrucci, Norman J Haughey
It has been increasingly recognized at the basic science level that perturbations in ceramide metabolism are associated with the development and progression of many age-related diseases. However, the translation of this work to the clinic has lagged behind. Understanding the factors longitudinally associated with plasma ceramides and dihydroceramides (DHCer) at the population level and how these lipid levels change with age, and by sex, is important for the clinical development of future therapeutics and biomarkers focused on ceramide metabolism...
December 2015: Aging Cell
https://www.readbyqxmd.com/read/26010541/cambinol-a-novel-inhibitor-of-neutral-sphingomyelinase-2-shows-neuroprotective-properties
#19
Mariana Figuera-Losada, Marigo Stathis, Joelle M Dorskind, Ajit G Thomas, Veera Venkata Ratnam Bandaru, Seung-Wan Yoo, Nicholas J Westwood, Graeme W Rogers, Justin C McArthur, Norman J Haughey, Barbara S Slusher, Camilo Rojas
Ceramide is a bioactive lipid that plays an important role in stress responses leading to apoptosis, cell growth arrest and differentiation. Ceramide production is due in part to sphingomyelin hydrolysis by sphingomyelinases. In brain, neutral sphingomyelinase 2 (nSMase2) is expressed in neurons and increases in its activity and expression have been associated with pro-inflammatory conditions observed in Alzheimer's disease, multiple sclerosis and human immunodeficiency virus (HIV-1) patients. Increased nSMase2 activity translates into higher ceramide levels and neuronal cell death, which can be prevented by chemical or genetic inhibition of nSMase2 activity or expression...
2015: PloS One
https://www.readbyqxmd.com/read/25611149/cerebrospinal-fluid-metabolomics-implicate-bioenergetic-adaptation-as-a-neural-mechanism-regulating-shifts-in-cognitive-states-of-hiv-infected-patients
#20
Alex M Dickens, Daniel C Anthony, Reena Deutsch, Michelle M Mielke, Timothy D W Claridge, Igor Grant, Donald Franklin, Debra Rosario, Thomas Marcotte, Scott Letendre, Justin C McArthur, Norman J Haughey
OBJECTIVES: To identify prognostic surrogate markers for change in cognitive states of HIV-infected patients. DESIGN: Longitudinal cerebrospinal fluid (CSF) samples were collected from 98 HIV-infected patients identified by temporal change in cognitive states classified as normal, stably impaired, improving and worsening. METHODS: The metabolic composition of CSF was analysed using H nuclear magnetic resonance (H NMR) spectroscopy that focused on energy metabolites...
March 13, 2015: AIDS
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