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https://www.readbyqxmd.com/read/29458226/-outbreaks-of-scabies-in-schools-and-use-of-ivermectin
#1
Josef A I Weigl
BACKGROUND: At Pentecost 2017 outbreaks of scabies occurred in three schools in Ploen County. Several classes were supposed to go on an excursion or had returned from an excursion with symptomatic kids. METHODS: Rapid investigation, on site outbreak confirmation, home visits of the environment of the index cases, simultaneous mass treatment and post exposure prophylaxis (PEP) with Ivermectin according to the outbreak characteristics were applied. RESULTS: The index case of school A was ill since 5 months, but was misdiagnosed as eczema...
February 19, 2018: Das Gesundheitswesen
https://www.readbyqxmd.com/read/29457230/impact-of-hand-eczema-on-quality-of-life-metropolitan-versus-non-metropolitan-areas
#2
Line B Nørreslet, Tove Agner, Jennifer A Sørensen, Niels E Ebbehøj, Jens P Bonde, Maja H Fisker
BACKGROUND: An inverse relationship between disease severity and health-related quality of life (HR-QoL) in patients with hand eczema is well established, but modifying effects of demographic variables have been less well studied. OBJECTIVE: To identify the influence of metropolitan versus non-metropolitan residence on the relationship between disease severity and HR-QoL in patients with occupational hand eczema. METHODS: The city of Copenhagen and the rest of Zealand were defined as metropolitan and non-metropolitan areas, respectively...
February 19, 2018: Contact Dermatitis
https://www.readbyqxmd.com/read/29455854/pathophysiology-and-management-of-mild-to-moderate-pediatric-atopic-dermatitis
#3
Kammi Yap Sayaseng, Peggy Vernon
Atopic dermatitis (AD), or eczema, is a chronic inflammatory skin condition characterized by relapsing pruritic and dry, scaly lesions. AD affects 10% to 20% of children in the United States and significantly affects the quality of life of patients and their families. Primary care providers (PCPs) are often the first point of contact for the management of AD symptoms. As many as 70% of patients with mild to moderate disease can be managed by a PCP, underscoring the need for these providers to understand basic AD pathophysiology and current standards of care...
March 2018: Journal of Pediatric Health Care
https://www.readbyqxmd.com/read/29453553/-microbiome-atopic-eczema-and-blockade-of-type-2-immunity
#4
REVIEW
M Köberle, T Biedermann
Atopic dermatitis affects roughly 20% of children and 3% of adults in Germany and other industrial countries, with an increasing prevalence. Its causality has still not been conclusively clarified but a type‑2 T‑helper cell mediated immunity reaction (type 2 immunity) dominates cutaneous inflammation. In the quest for the underlying pathogenic mechanisms and the development of improved prevention and treatment options, attention is also increasingly being paid to the influence of microbial colonization...
February 16, 2018: Der Hautarzt; Zeitschrift Für Dermatologie, Venerologie, und Verwandte Gebiete
https://www.readbyqxmd.com/read/29453208/parent-reported-prevalence-and-persistence-of-19-common-child-health-conditions
#5
Tracy Liu, Raghu Lingam, Kate Lycett, Fiona K Mensah, Joshua Muller, Harriet Hiscock, Md Hamidul Huque, Melissa Wake
OBJECTIVE: To estimate prevalence and persistence of 19 common paediatric conditions from infancy to 14-15 years. DESIGN: Population-based prospective cohort study. SETTING: Australia. PARTICIPANTS: Parallel cohorts assessed biennially from 2004 to 2014 from ages 0-1 and 4-5 years to 10-11 and 14-15 years, respectively, in the Longitudinal Study of Australian Children. MAIN OUTCOME MEASURES: 19 health conditions: 17 parent-reported, 2 (overweight/obesity, obesity) directly assessed...
February 16, 2018: Archives of Disease in Childhood
https://www.readbyqxmd.com/read/29451112/-regained-freedom-for-patients-with-atopic-dermatitis-fast-and-long-term-effects-of-dupilumab
#6
T Nijsten, D J Hijnen
Dupilumab is the first and long-awaited biological for treatment of moderate to severe atopic dermatitis. In randomised clinical trials approximately 40% of patients using dupilumab 300 mg every two weeks were clear or almost clear of their eczema after 16 and 52 weeks. We now face the challenge of patient stratification to limit the budget impact of dupilumab and hope that more targeted therapies for atopic dermatitis will follow soon.
2018: Nederlands Tijdschrift Voor Geneeskunde
https://www.readbyqxmd.com/read/29450557/eczema-s-big-break-in-hollywood
#7
Amit Om
No abstract text is available yet for this article.
February 1, 2018: JAMA Dermatology
https://www.readbyqxmd.com/read/29449296/gp-and-parent-dissonance-about-the-assessment-and-treatment-of-childhood-eczema-in-primary-care-a-qualitative-study
#8
Kingsley Powell, Emma Le Roux, Jonathan Banks, Matthew J Ridd
OBJECTIVES: To compare parents' and clinicians' perspectives on the assessment and treatment of children with eczema in primary care. DESIGN: Qualitative interview study with purposive and snowball sampling and thematic analysis. SETTING: 14 general practices in the UK. PARTICIPANTS: 11 parents of children with eczema and 15 general practitioners (GPs) took part in semistructured individual interviews. RESULTS: We identified several areas of dissonance between parents and GPs...
February 15, 2018: BMJ Open
https://www.readbyqxmd.com/read/29446153/eating-fish-and-farm-life-reduce-allergic-rhinitis-at-the-age-of-twelve
#9
Styliana Vasileiadou, Göran Wennergren, Frida Strömberg Celind, Nils Åberg, Rolf Pettersson, Bernt Alm, Emma Goksör
BACKGROUND: The prevalence of allergic rhinitis has increased, but the cause of this rise is partly unknown. Our aim was to analyse the prevalence, risk factors and protective factors for allergic rhinitis in 12-year-old Swedish children. METHODS: Data were collected from a prospective, longitudinal cohort study of children born in western Sweden in 2003. The parents answered questionnaires when the children were six months to 12 years. The response rate at 12 years was 76% (3,637/4,777) of the questionnaires distributed...
February 15, 2018: Pediatric Allergy and Immunology
https://www.readbyqxmd.com/read/29444346/prenatal-vitamin-d-status-and-respiratory-and-allergic-outcomes-in-childhood-a-meta-analysis-of-observational-studies
#10
REVIEW
Rosa M Pacheco-González, Luis García-Marcos, Eva Morales
Prenatal vitamin D status may influence offspring's respiratory and allergic outcomes; however, evidence is inconclusive. A systematic review and meta-analysis was conducted on the association between 25-hydroxyvitamin D [25(OH)D] levels in maternal blood in pregnancy or cord blood at birth with the risk of offspring's respiratory and allergic conditions. Two independent researchers conducted systematic searches for observational studies published until May 2017 using defined keywords on vitamin D and health outcomes, including respiratory tract infections (RTIs), wheeze, asthma, atopic eczema, allergic rhinitis, allergic sensitization, and lung function...
February 14, 2018: Pediatric Allergy and Immunology
https://www.readbyqxmd.com/read/29442292/topical-immunotherapy-of-alopecia-areata-a-large-retrospective-study
#11
Nicola Zerbinati, Cristina Esposito, Edoardo D'Este, Alberto Calligaro, Rossano Valsecchi
INTRODUCTION: Topical immunotherapy is frequently used in the treatment of alopecia areata (AA) although few studies report long-term follow-up. Our goals were to determine the efficacy and the prognostic factors of topical immunotherapy in a large cohort of patients with AA treated in the departments of Dermatology and Venereology of Bergamo, Como and Pavia, from 1978 to January 2016. METHODS: A total of 252 patients with AA were evaluated retrospectively. RESULTS: All our patients developed an allergic reaction to a 2% solution of dinitrochlorobenzene (DNCB) or squaric acid dibutylester (SADBE) or diphenylcyclopropenone (DPCP)...
February 13, 2018: Dermatology and Therapy
https://www.readbyqxmd.com/read/29441539/wet-work-and-healthcare-workers-use-of-hand-disinfectants-not-associated-with-self-reported-eczema
#12
T Keegel, R L Nixon
No abstract text is available yet for this article.
February 2018: British Journal of Dermatology
https://www.readbyqxmd.com/read/29441531/the-time-healthcare-workers-wear-disposable-gloves-daily-is-associated-with-hand-eczema-in-a-dose-dependent-fashion
#13
C Apfelbacher
No abstract text is available yet for this article.
February 2018: British Journal of Dermatology
https://www.readbyqxmd.com/read/29439692/automated-chart-review-utilizing-natural-language-processing-algorithm-for-asthma-predictive-index
#14
Harsheen Kaur, Sunghwan Sohn, Chung-Il Wi, Euijung Ryu, Miguel A Park, Kay Bachman, Hirohito Kita, Ivana Croghan, Jose A Castro-Rodriguez, Gretchen A Voge, Hongfang Liu, Young J Juhn
BACKGROUND: Thus far, no algorithms have been developed to automatically extract patients who meet Asthma Predictive Index (API) criteria from the Electronic health records (EHR) yet. Our objective is to develop and validate a natural language processing (NLP) algorithm to identify patients that meet API criteria. METHODS: This is a cross-sectional study nested in a birth cohort study in Olmsted County, MN. Asthma status ascertained by manual chart review based on API criteria served as gold standard...
February 13, 2018: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/29434645/atopy-and-related-clinical-symptoms-among-swiss-medical-students-from-2007-to-2015
#15
Lukas Steinegger, Stephan Regenass, Lucas M Bachmann, Elsbeth Probst, Urs C Steiner
Background: Atopic allergy is a widespread disease with increasing prevalence in the second half of the twentieth century and is most often associated with clinical symptoms, like rhinoconjunctivitis, asthma or eczema. This study explored the prevalence of atopy and polysensitization in nine cohorts of Swiss medical students during the period of 2007-2015. Furthermore, the self-reported allergic symptoms, such as rhinoconjunctivitis, asthma and eczema, among students with and without atopy were assessed...
2018: Allergy, Asthma, and Clinical Immunology
https://www.readbyqxmd.com/read/29433390/ethnomedicine-phytochemistry-and-pharmacology-of-smilax-glabra-an-important-traditional-chinese-medicine
#16
Shiyao Hua, Yiwei Zhang, Jiayue Liu, Lin Dong, Jun Huang, Dingbo Lin, Xueyan Fu
Smilax glabra (SG) Roxb., a well-known traditional Chinese medicine, has been extensively used worldwide for its marked pharmacological activities for treating syphilitic poisoned sores, limb hypertonicity, morbid leucorrhea, eczema pruritus, strangury due to heat, carbuncle toxin, and many other human ailments. Approximately 200 chemical compounds have been isolated from SG Roxb., and the major components have been determined to be flavonoids and flavonoid glycosides, phenolic acids, and steroids. Among these active compounds, the effects of astilbin, which is used as a quality control marker to determine the quality of SG Roxb...
February 12, 2018: American Journal of Chinese Medicine
https://www.readbyqxmd.com/read/29428424/parvovirus-b19-and-in-situ-immune-response-in-eczema-and-psoriasis-skin-lesions-of-patients-from-the-brazilian-amazon-region
#17
Adriana Christie Lacerda Simões, Tinara Leila de Souza Aarão, Jorge Rodrigues de Sousa, Diogo Lima Prudente, Yaisa Gomes de Castro, Rodrigo Bona Maneschy, Hellen Thais Fuzii, Juarez Antonio Simões Quaresma
Parvovirus B19 (PVB19) is a virus found in the skin that causes asymptomatic infections and can exist in the host for long periods to time. The virus induces a local inflammatory response and is associated with the development of arthritis and other autoimmunes diseases. Parvovirus B19 DNA was investigated by PCR in the skin of 20 patients with psoriasis and 20 patients with eczema. Additionally, immunohistochemistry was used to characterize the expression of cytokines in these lesions. The sociodemographic variables were similar in the two groups studied...
February 8, 2018: Microbial Pathogenesis
https://www.readbyqxmd.com/read/29422431/dupilumab-for-the-treatment-of-atopic-dermatitis
#18
S Ferreira, T Torres
Atopic dermatitis (AD) is a common, chronic, inflammatory skin disorder with high physical and emotional burden. AD usually starts in early childhood and has a heterogeneous course. Emerging evidence suggests that IL-4 and IL-13 are key cytokines in the immunopathogenesis of AD. Dupilumab is a monoclonal antibody directed against IL-4 receptor α subunit, that blocks both IL-4 and IL-13 signaling. Data from Phase I-III studies revealed that dupilumab, administered as monotherapy or with topical corticosteroids, is effective and well tolerated in the treatment of adult patients with moderate-to-severe AD...
February 5, 2018: Actas Dermo-sifiliográficas
https://www.readbyqxmd.com/read/29421274/autonomous-role-of-wiskott-aldrich-syndrome-platelet-deficiency-in-inducing-autoimmunity-and-inflammation
#19
Lucia Sereni, Maria Carmina Castiello, Francesco Marangoni, Achille Anselmo, Dario di Silvestre, Sara Motta, Elena Draghici, Stefano Mantero, Adrian J Thrasher, Silvia Giliani, Alessandro Aiuti, Pierluigi Mauri, Luigi D Notarangelo, Marita Bosticardo, Anna Villa
BACKGROUND: Wiskott-Aldrich Syndrome (WAS) is an X-linked immunodeficiency characterized by eczema, infections and susceptibility to develop autoimmunity and malignancies. Thrombocytopenia is a constant finding, but its pathogenesis remains elusive. OBJECTIVE: To dissect the basis of WAS platelet (PLT) defect we used a novel conditional mouse model (CoWas) lacking WASp only in the megakaryocytic lineage in presence of a normal immunological environment and in parallel we analysed samples obtained from WAS patients...
February 5, 2018: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29415330/maternal-supplementation-alone-with-l-rhamnosus-hn001-during-pregnancy-and-breastfeeding-does-not-reduce-infant-eczema
#20
Kristin Wickens, Christine Barthow, Edwin A Mitchell, Thorsten V Stanley, Gordon Purdie, Judy Rowden, Janice Kang, Fiona Hood, Lieke van den Elsen, Elizabeth Forbes-Blom, Isobel Franklin, Phillipa Barnes, Penny Fitzharris, Robyn M Maude, Peter Stone, Peter Abels, Rinki Murphy, Julian Crane
BACKGROUND: In a randomised placebo-controlled trial, we previously found that the probiotic Lactobacillus rhamnosus HN001 (HN001) taken by mothers from 35 weeks gestation until 6 months post-partum if breastfeeding and their child from birth to age 2 years halved the risk of eczema during the first 2 years of life. We aimed to test whether maternal supplementation alone is sufficient to reduce eczema, and compare this to our previous study when both mothers and their child were supplemented...
February 7, 2018: Pediatric Allergy and Immunology
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