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https://www.readbyqxmd.com/read/29680092/improving-value-for-patients-with-eczema
#1
Julie Block
OBJECTIVE: Chronic diseases now represent a cost majority in the United States health care system. Contributing factors to rising costs include expensive novel and emerging therapies, under-treatment of disease, under-management of comorbidities, and patient dissatisfaction with care results. Critical to identifying replicable improvement methods is a reliable model to measure value. STUDY DESIGN: If we understand value within healthcare consumerism to be equal to a patient's health outcome improvement over costs associated with care (Value=Outcomes/Costs), we can use this equation to measure the improvement of value...
April 2018: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/29679657/eleven-loci-with-new-reproducible-genetic-associations-with-allergic-disease-risk
#2
Manuel Ar Ferreira, Judith M Vonk, Hansjörg Baurecht, Ingo Marenholz, Chao Tian, Joshua D Hoffman, Quinta Helmer, Annika Tillander, Vilhelmina Ullemar, Yi Lu, Franz Rüschendorf, David A Hinds, Norbert Hübner, Stephan Weidinger, Patrik Ke Magnusson, Eric Jorgenson, Young-Ae Lee, Dorret I Boomsma, Robert Karlsson, Catarina Almqvist, Gerard H Koppelman, Lavinia Paternoster
BACKGROUND: A recent genome-wide association study (GWAS) identified 99 loci that contain genetic risk variants shared between asthma, hay fever and eczema. Many more risk loci shared between these common allergic diseases remain to be discovered, which could point to new therapeutic opportunities. OBJECTIVE: To identify novel risk loci shared between asthma, hay fever and eczema by applying a gene-based test of association to results from a published GWAS that included data from 360,838 individuals...
April 18, 2018: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29678409/phototherapy-for-neonatal-hyperbilirubinemia-and-childhood-eczema-rhinitis-and-wheeze
#3
Elizabeth Huiwen Tham, Evelyn Xiu Ling Loo, Anne Goh, Oon Hoe Teoh, Fabian Yap, Kok Hian Tan, Keith M Godfrey, Hugo Van Bever, Bee Wah Lee, Yap Seng Chong, Lynette Pei-Chi Shek
BACKGROUND: The pathogenesis of allergic diseases in childhood may be attributed to influences of early environmental stimuli on fetal and neonatal immune regulation. Neonatal hyperbilirubinemia is common in the Asian population and up to 20% of infants require phototherapy. We examined the hypothesis that phototherapy for neonatal hyperbilirubinemia modulates the infant's risk of developing eczema, rhinitis and wheeze in the Growing Up in Singapore Towards healthy Outcomes (GUSTO) birth cohort...
March 24, 2018: Pediatrics and Neonatology
https://www.readbyqxmd.com/read/29677460/association-of-environmental-exposure-to-heavy-metals-and-eczema-in-us-population-analysis-of-blood-cadmium-lead-and-mercury
#4
Jia Wei, Junfeng Jim Zhang, John S Ji
OBJECTIVES: We aim to explore the association between blood heavy metal concentrations of cadmium, lead, and mercury with ever-report of eczema in the US population. METHODS: We used NHANES cross-sectional data from 2005-2006. Eczema was measured among 4509 adults and 3898 non-adults. The association between eczema and tertiles of concentrations of cadmium, lead, mercury was estimated using multivariate logistic regression models adjusted for different confounding variables...
April 20, 2018: Archives of Environmental & Occupational Health
https://www.readbyqxmd.com/read/29676534/consensus-based-european-guidelines-for-treatment-of-atopic-eczema-atopic-dermatitis-in-adults-and-children-part-i
#5
A Wollenberg, S Barbarot, T Bieber, S Christen-Zaech, M Deleuran, A Fink-Wagner, U Gieler, G Girolomoni, S Lau, A Muraro, M Czarnecka-Operacz, T Schäfer, P Schmid-Grendelmeier, D Simon, Z Szalai, J C Szepietowski, A Taïeb, A Torrelo, T Werfel, J Ring
This guideline was developed as a joint interdisciplinary European project, including physicians from all relevant disciplines as well as patients. It is a consensus-based guideline, taking available evidence from other guidelines, systematic reviews and published studies into account. This first part of the guideline covers methods, patient perspective, general measures and avoidance strategies, basic emollient treatment and bathing, dietary intervention, topical anti-inflammatory therapy, phototherapy and antipruritic therapy, whereas the second part covers antimicrobial therapy, systemic treatment, allergen-specific immunotherapy, complementary medicine, psychosomatic counselling and educational interventions...
May 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29676119/-optimize-preparation-of-compound-licorice-microemulsion-with-d-optimal-design
#6
Shu-Wei Ma, Yong-Jie Wang, Cheng Chen, Yue Qiu, Qing Wu
In order to increase the solubility of essential oil in compound licorice microemulsion and improve the efficacy of the decoction for treating chronic eczema, this experiment intends to prepare the decoction into microemulsion. The essential oil was used as the oil phase of the microemulsion and the extract was used as the water phase. Then the microemulsion area and maximum ratio of water capacity was obtained by plotting pseudo-ternary phase diagram, to determine the appropriate types of surfactant and cosurfactant, and Km value-the mass ratio between surfactant and cosurfactant...
March 2018: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29676071/differences-in-genetic-variations-between-treatable-and-recalcitrant-atopic-dermatitis-in-korean
#7
Myungsoo Jun, Hye Young Wang, Solam Lee, Eunhee Choi, Hyeyoung Lee, Eung Ho Choi
PURPOSE: Variations in barrier- or immune response-related genes are closely related to the development of atopic dermatitis (AD). This study was designed to identify genetic variations and clinical features to predict 'recalcitrant AD.' METHODS: AD patients were classified as treatable and recalcitrant. Treatable AD patients showed satisfactory clinical improvement with basic and topical treatments. Recalcitrant AD patients used systemic immune-suppressants for over 4 weeks as they had not shown clinical improvement with basic and topical treatments...
May 2018: Allergy, Asthma & Immunology Research
https://www.readbyqxmd.com/read/29672835/report-from-the-fifth-international-consensus-meeting-to-harmonize-core-outcome-measures-for-atopic-eczema-dermatitis-clinical-trials-home-initiative
#8
J R Chalmers, K S Thomas, C Apfelbacher, H C Williams, C A Prinsen, P I Spuls, E Simpson, L A A Gerbens, M Boers, S Barbarot, J F Stalder, K Abuabara, V Aoki, M Ardeleanu, J Armstrong, B Bang, T L Berents, T Burton, L Butler, T Chubachi, A Cresswell-Melville, A DeLozier, L Eckert, L Eichenfield, C Flohr, M Futamura, A Gadkari, E S Gjerde, K F van Halewijn, C Hawkes, L Howells, L Howie, R Humphreys, H A Ishii, Y Kataoka, I Katayama, W Kouwenhoven, S M Langan, Y A Leshem, S Merhand, P Mina-Osorio, H Murota, T Nakahara, F P Nunes, U Nygaard, M Nygårdas, Y Ohya, E Ono, E Rehbinder, N K Rogers, G L E Romeijn, M L A Schuttelaar, A V Sears, M A Simpson, J A Singh, J Srour, B Stuart, Å Svensson, G Talmo, H Talmo, H D Teixeira, J P Thyssen, G Todd, F Torchet, A Volke, L von Kobyletzki, E Weisshaar, A Wollenberg, M Zaniboni
This is the report from the fifth meeting of the Harmonising Outcome Measures for Eczema initiative (HOME V). The meeting was held on 12-14 June 2017 in Nantes, France, with 81 participants. The main aims of the meeting were (i) to achieve consensus over the definition of the core domain of long-term control and how to measure it and (ii) to prioritize future areas of research for the measurement of the core domain of quality of life (QoL) in children. Moderated whole-group and small-group consensus discussions were informed by presentations of qualitative studies, systematic reviews and validation studies...
April 19, 2018: British Journal of Dermatology
https://www.readbyqxmd.com/read/29671670/challenges-in-assessing-rare-risks-associated-with-topical-calcineurin-inhibitors-for-the-treatment-of-eczema
#9
Brent L Cao
No abstract text is available yet for this article.
April 19, 2018: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/29668088/atopic-dermatitis-risk-estimates-for-hand-eczema
#10
S Kezic
No abstract text is available yet for this article.
April 2018: British Journal of Dermatology
https://www.readbyqxmd.com/read/29665062/phase-1-studies-to-assess-the-safety-tolerability-and-pharmacokinetics-of-jte-052-a-novel-janus-kinase-inhibitor-ointment-in-japanese-healthy-volunteers-and-patients-with-atopic-dermatitis
#11
Hidemi Nakagawa, Osamu Nemoto, Hiroyuki Yamada, Takeshi Nagata, Noriko Ninomiya
The purpose of the present two phase 1 studies was to assess the safety, tolerability and pharmacokinetics for topical application of a novel Janus kinase (JAK) inhibitor, JTE-052, in Japanese healthy adult male volunteers and Japanese adult patients with atopic dermatitis (AD). Additionally, exploratory investigation was performed on the efficacy for disease severity and pruritus score in AD patients. In the QBX1-1 study, the cutaneous safety of JTE-052 ointment by a patch test and a photo patch test was assessed in an intra-individual comparative study using placebo ointment, white petrolatum and non-application as comparators...
April 17, 2018: Journal of Dermatology
https://www.readbyqxmd.com/read/29661500/severity-of-eczema-and-mental-health-problems-in-japanese-schoolchildren-the-tommo-child-health-study
#12
Yasutaka Kuniyoshi, Masahiro Kikuya, Masako Miyashita, Chizuru Yamanaka, Mami Ishikuro, Taku Obara, Hirohito Metoki, Naoki Nakaya, Fuji Nagami, Hiroaki Tomita, Atsushi Hozawa, Ichiro Tsuji, Shigeo Kure, Nobuo Yaegashi, Masayuki Yamamoto, Shinichi Kuriyama
BACKGROUND: The association between eczema and mental health problems in schoolchildren has been underexplored. We aimed to investigate this association with the validated questionnaires. METHODS: Of 46,648 invited children, we analyzed 9954 (21.3%) in the 2nd to the 8th grades from the ToMMo Child Health Study conducted in 2014 and 2015, a cross-sectional survey in Miyagi Prefecture, Japan. We defined eczema status as "normal," "mild/moderate," or "severe," based on the presence of persistent flexural eczema and sleep disturbance, according to the International Study of Asthma and Allergies in Childhood (ISAAC) Eczema Symptom Questionnaire...
April 13, 2018: Allergology International: Official Journal of the Japanese Society of Allergology
https://www.readbyqxmd.com/read/29644903/patients-with-chronic-rhinosinusitis-and-obstructive-sleep-apnea-have-increased-paroxysmal-limb-movement
#13
Mahboobeh Mahdavinia, Jessica W Hui, Mohamed Zitun, Alejandra Lastra, James J Herdegen, Christopher D Codispoti, Rafsa J Khan, Phillip S LoSavio, Pete S Batra
BACKGROUND: Patients with chronic rhinosinusitis (CRS) frequently experience sleep disruption and are at a higher than normal risk for obstructive sleep apnea (OSA). The purpose of this study was to determine how CRS affects polysomnography findings and sleep-related breathing in OSA. METHODS: A cohort study was performed that included 107 adult patients with CRS and comorbid OSA (CRS+OSA group) and 137 patients with OSA and without CRS as the control group. An electronic medical records database was used to identify eligible subjects...
March 2018: American Journal of Rhinology & Allergy
https://www.readbyqxmd.com/read/29644719/the-profiling-and-identification-of-chemical-components-prototypes-and-metabolites-of-run-zao-zhi-yang-capsule-in-rat-plasma-urine-and-bile-by-an-uplc-q-tof-ms-e-based-high-throughput-strategy
#14
Shan Lin, Xinyi Yue, Danwei Ouyang, Quan Li, Peiming Yang
Run-zao-zhi-yang (RZZY) capsule, a traditional Chinese medicine formula (TCMF), has been popularly used for the treatment of dermatitis and eczema. However, few studies have been carried out on RZZY and its metabolites. In this study, we developed a three-step strategy to rapidly characterize the chemical constituents and metabolites of RZZY by using ultra high performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry. A total of 41 chemical components were characterized from RZZY...
April 12, 2018: Biomedical Chromatography: BMC
https://www.readbyqxmd.com/read/29644714/design-synthesis-and-biological-evaluation-of-2-substituted-2-3-4-9-tetrahydrospiro-%C3%AE-carboline-3-carboxylic-acid-derivatives-as-first-in-class-mast-cell-stabilizers
#15
Jatinder Singh, Ramanpreet Shah, Dhandeep Singh, Amteshwar S Jaggi, Nirmal Singh
Mast cell degranulation plays a momentous role in myriad diseases like asthma, eczema, allergic rhinitis, and conjunctivitis as well as anaphylactic shock; hence, there is an unmet need for developing new mast cells stabilizers. The reported mast cell stabilizers have a heterocyclic moiety and an acidic group. Furthermore, the role of tryptophan in suppression of mast cell activation is established. Hence, we prepared constrained analogs of tryptophan, which are derivatives of 2,3,4,9-tetrahydrospiro-β-carboline-3-carboxylic acid, and evaluated them for ex vivo inhibition of compound 48/80-induced mast degranulation activity...
April 12, 2018: Archiv der Pharmazie
https://www.readbyqxmd.com/read/29628376/childhood-predictors-of-lung-function-trajectories-and-future-copd-risk-a-prospective-cohort-study-from-the-first-to-the-sixth-decade-of-life
#16
Dinh S Bui, Caroline J Lodge, John A Burgess, Adrian J Lowe, Jennifer Perret, Minh Q Bui, Gayan Bowatte, Lyle Gurrin, David P Johns, Bruce R Thompson, Garun S Hamilton, Peter A Frith, Alan L James, Paul S Thomas, Deborah Jarvis, Cecilie Svanes, Melissa Russell, Stephen C Morrison, Iain Feather, Katrina J Allen, Richard Wood-Baker, John Hopper, Graham G Giles, Michael J Abramson, Eugene H Walters, Melanie C Matheson, Shyamali C Dharmage
BACKGROUND: Lifetime lung function is related to quality of life and longevity. Over the lifespan, individuals follow different lung function trajectories. Identification of these trajectories, their determinants, and outcomes is important, but no study has done this beyond the fourth decade. METHODS: We used six waves of the Tasmanian Longitudinal Health Study (TAHS) to model lung function trajectories measured at 7, 13, 18, 45, 50, and 53 years. We analysed pre-bronchodilator FEV1 z-scores at the six timepoints using group-based trajectory modelling to identify distinct subgroups of individuals whose measurements followed a similar pattern over time...
April 5, 2018: Lancet Respiratory Medicine
https://www.readbyqxmd.com/read/29622825/gastrointestinal-food-allergy-in-ghanaian-children-a-case-series
#17
Taiba J Afaa, Adwoa Ka Afrane, Victor Etwire
Background: Food allergy is an adverse health effect arising from a specific immune response that occurs reproducibly on exposure to a given food. Food allergies are classified into three types: Ig(immunoglobulin)E mediated, mixed IgE and cell mediated and cell-mediated non IgE mediated. Gastrointestinal (GIT) food allergy has classically encompassed a number of different clinical entities: food protein-induced enterocolitis syndrome (FPIES), food protein-induced proctocolitis (FPIP), food protein-induced enteropathy and eosinophilic gastrointestinal disorders (EGID)...
September 2017: Ghana Medical Journal
https://www.readbyqxmd.com/read/29621411/the-southern-sweden-adolescent-allergy-cohort-prevalence-of-allergic-diseases-and-cross-sectional-associations-with-individual-and-social-factors
#18
Therese Sterner, Ada Uldahl, Åke Svensson, Jonas Björk, Cecilia Svedman, Christel Nielsen, Alf Tunsäter, Magnus Bruze, Hampus Kiotseridis
OBJECTIVES: Asthma and allergic diseases are the most frequent chronic diseases in childhood worldwide, and considered a burden for the affected children and their families. The diseases impose an economic burden on society if not diagnosed and treated properly and management of and these diseases are challenging for healthcare professionals. The aim of the present investigation was to assess the prevalence of allergic diseases in an unselected cohort of adolescents in southern Sweden...
April 5, 2018: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/29620631/pediatric-hyperimmunoglobulin-e-syndrome-a-case-series-of-4-children-in-china
#19
Huifeng Fan, Li Huang, Diyuan Yang, Yunting Lin, Gen Lu, Yaping Xie, Jialu Yu, Dongwei Zhang
Hyperimmunoglobulin E syndromes (HIES) are rare primary immunodeficiency diseases characterized by markedly elevated serum immunoglobulin (Ig) E, recurrent pneumonia, and chronic eczema. To date, information about pediatric HIES is limited. We aimed to evaluate the spectrum of clinical and immunological features in pediatric patients with HIES in China.We retrospectively reviewed the cases of 4 pediatric patients with HIES followed at the Guangzhou Women and Children's Medical Center from May 2013 to September 2017...
April 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29620611/bleach-for-atopic-dermatitis-beyond-antimicrobials
#20
Melody Maarouf, Vivian Y Shi
Individuals with atopic dermatitis (AD) have used bleach baths to treat superinfections, although their mechanism of action is not well understood. The ClinicalTrials.gov, National Eczema Association, and PubMed databases were searched for studies that investigate the role bleach plays in modulating AD. Fifteen studies were included in this review. Bleach bath improves clinical symptoms of AD and restores surface microbiome by eradicating bacteria, most notably Staphylococcus aureus. Many studies have noted that this antimicrobial effect has reduced the need for topical corticosteroids or topical antibiotics...
April 3, 2018: Dermatitis
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