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Blastomycosis

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https://www.readbyqxmd.com/read/29771758/opportunistic-fungal-infection-in-children-and-management
#1
Joseph M Lam
PURPOSE OF REVIEW: An opportunistic mycosis is a fungal agent of low pathogenicity that specifically infects immunocompromised hosts. Advances in transplantation, preterm care, immunosuppressive therapies and intensive care, have lead to the emergence of pediatric patients with serious immunodeficiency who are vulnerable to nonpathogenic fungi. RECENT FINDINGS: The advent of the use of biologic agents in pediatric disease as well as the advances in care of preterm and immunosuppressed patients opens up a new cohort of patients at risk of opportunistic mycotic infections...
May 15, 2018: Current Opinion in Pediatrics
https://www.readbyqxmd.com/read/29770046/blastomycosis-hospitalizations-in-northwestern-ontario-2006-2015
#2
S Litvinjenko, D Lunny
Background: Blastomycosis, caused by the organism Blastomyces dermatitidis, is an invasive fungal disease found in Central Canada and Central and Midwestern United States. Objective: To describe trends in and epidemiology of hospitalized cases of blastomycosis cases reported among northwestern Ontario residents between 2006 and 2015. Methods: Blastomycosis hospitalization data were extracted from the Discharge Abstract Database (DAD), accessed through IntelliHEALTH Ontario...
October 5, 2017: Canada Communicable Disease Report, Relevé des Maladies Transmissibles Au Canada
https://www.readbyqxmd.com/read/29573229/urinary-tract-blastomycosis-diagnosed-by-urine-cytology
#3
Shifteh Vahidi, Amy Beckman, Kellen Albrecht, Sophie Arbefeville, Patricia Ferrieri, Khalid Amin
Urinary tract blastomycosis is an uncommon manifestation of disseminated Blastomyces infection. Here, we report a 50-year-old male with common variable immunodeficiency who presented with urinary symptoms and a renal mass concerning for a kidney neoplasm. Urine cytology revealed typical broad-based budding yeasts with thick-walled refractile capsules, leading to diagnosis of urinary tract blastomycosis. In this case, urine cultures were negative, and urine cytology was the main method of diagnosis of blastomycosis...
March 23, 2018: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/29568716/cutaneous-intranasal-blastomycosis-infection-in-two-patients-from-southern-west-virginia-diagnostic-dilemma
#4
Aaron R Kuzel, Muhammad Uzair Lodhi, Intekhab Askari Syed, Tehmina Zafar, Umar Rahim, Mehenaz Hanbazazh, Nadia Naumova, Mustafa Rahim
Blastomycosis is a dimorphic fungus caused by the species of Blastomyces dermatitidisand Blastomyces gilchristii, which are endemic to the Ohio River and Mississippi River Valleys. It is commonly found in soil or decomposing wood. It is capable of infecting both immunocompromised and immunocompetent patients via the respiratory tract by inhaling conidia, where it may remain asymptomatic for a prolonged period of time. Extrapulmonary complications can occur in disseminated disease due to haematogenous spread from the lungs to other organ systems...
January 21, 2018: Curēus
https://www.readbyqxmd.com/read/29547956/chronic-pulmonary-blastomycosis-mimicking-pulmonary-tuberculosis
#5
Matthew T Koroscil, Andrew Skabelund
Introduction: Blastomyces dermatitidis is a dimorphic fungus endemic to the Mississippi River valley. We describe a rare case of chronic pulmonary blastomycosis complicated by large pulmonary cavitation in a young service member who was misdiagnosed with active pulmonary tuberculosis. Case Presentation: A 25-year-old active duty male presented to his primary care provider with complaints of hemoptysis, fatigue, weight loss, and fever. Computed tomography chest with contrast identified a large cavitary lesion in the right upper lobe (RUL)...
March 14, 2018: Military Medicine
https://www.readbyqxmd.com/read/29532714/turning-on-virulence-mechanisms-that-underpin-the-morphologic-transition-and-pathogenicity-of-blastomyces
#6
Joseph A McBride, Gregory M Gauthier, Bruce S Klein
This review article focuses on the mechanisms underlying temperature adaptation and virulence of the etiologic agents of blastomycosis, Blastomyces dermatitidis, Blastomyces gilchristii, and Blastomyces percursus. In response to temperature, Blastomyces undergoes a reversible morphologic switch between hyphae and yeast known as the phase transition. The conversion to yeast for Blastomyces and related thermally dimorphic fungi is essential for virulence. In the yeast phase, Blastomyces upregulates the essential virulence factor, BAD1, which promotes attachment to host cells, impairs activation of immune cells, and blunts cytokine release...
March 13, 2018: Virulence
https://www.readbyqxmd.com/read/29512289/disseminated-blastomycosis-in-a-transplant-patient
#7
Douglas Challener, Omar Abu Saleh
A 51-year-old woman from Wisconsin with past medical history of kidney transplantation from her sibling 8 weeks prior, presented with symptoms of shortness of breath, cough, and a new skin rash over a 2-week period.
April 2018: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://www.readbyqxmd.com/read/29486592/pyoderma-gangranosum-like-blastomycosis
#8
Jessica Mak, Ayman Al Habeeb, Mona Al Kalabi, Afsaneh Alavi
Blastomyces dermatitidis is typically contracted through inhalation of the dimorphic conidia, resulting in pulmonary infection as well as extrapulmonary disease through hematogenous spread. Blastomycosis is considered one of the great mimickers in medicine, with verrucous cutaneous blastomycosis resembling skin malignancy and B dermatitidis pulmonary infections often confused with lung cancer. Cutaneous blastomycosis can also often mimic pyoderma gangrenosum and should be considered in the differential diagnosis in any suspected case...
February 1, 2018: Journal of Cutaneous Medicine and Surgery
https://www.readbyqxmd.com/read/29462233/blastomycosis-like-pyoderma-arising-in-lichen-planus
#9
Stephanie Kao, Ramsin Yadgar, Thomas Enelow, Adam Friedman
Blastomycosis-like pyoderma (BLP) is a rare reactive skin disease that is most commonly caused by bacterial infection. Herein we present a case of BLP arising in lichen planus, a chronic inflammatory disease. We propose Wolf's isotopic response, or the appearance of a new skin disease at the site of an existing and unrelated disease, as the underlying molecular mechanism responsible for this unusual physical presentation. It is important that clinicians recognize atypical morphologies such as BLP, which mimics squamous cell carcinoma both clinically and pathologically...
February 1, 2018: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/29229716/disseminated-blastomycosis-in-a-57-year-old-man-working-in-construction
#10
Daniel Dalcin, Roger Sandre
No abstract text is available yet for this article.
December 11, 2017: CMAJ: Canadian Medical Association Journal, Journal de L'Association Medicale Canadienne
https://www.readbyqxmd.com/read/29198783/common-child-and-adolescent-cutaneous-infestations-and-fungal-infections
#11
Sherman J Alter, Megan B McDonald, Julie Schloemer, Ryan Simon, Julian Trevino
Cutaneous infections and infestations are common among children and adolescents. Ectoparasitic infestations affect individuals across the globe. Head lice, body lice, scabies, and infestations with bed bugs are seen in individuals who reside in both resource poor areas and in developed countries. Superficial cutaneous and mucosal candida infections occur throughout the life cycle. Dermatophyte infections of keratin-containing skin and skin structures result in tinea capitis (scalp), tinea corporis (body), tinea pedis (foot), and tinea unguium (nails)...
January 2018: Current Problems in Pediatric and Adolescent Health Care
https://www.readbyqxmd.com/read/29195765/central-nervous-system-blastomycosis-diagnosed-using-the-mvista%C3%A2-blastomyces-quantitative-antigen-enzyme-immunoassay-test-on-cerebrospinal-fluid-a-case-report-and-review-of-the-literature
#12
REVIEW
Andrew Walkty, Yoav Keynan, James Karlowsky, Perry Dhaliwal, John Embil
Blastomyces dermatitidis is a thermally dimorphic fungus that is capable of causing pulmonary and extra-pulmonary disease, including infections of the central nervous system (CNS). Diagnosis of CNS blastomycosis with non-invasive testing can be difficult, and a surgical biopsy may ultimately be required for microbiological and/or histopathological confirmation. A case of B. dermatitidis meningitis is presented where the diagnosis was made by testing cerebrospinal fluid (CSF) using the MVista® Blastomyces Quantitative Antigen Enzyme Immunoassay test...
February 2018: Diagnostic Microbiology and Infectious Disease
https://www.readbyqxmd.com/read/29169917/primary-cutaneous-blastomycosis-after-inoculation-from-a-woodworking-blade
#13
Barry Ladizinski, Nicole Joy, David C Reid
No abstract text is available yet for this article.
January 2018: Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29016315/case-report-molecular-confirmation-of-lobomycosis-in-an-italian-traveler-acquired-in-the-amazon-region-of-venezuela
#14
Anna Beltrame, Patrizia Danesi, Claudio Farina, Pierantonio Orza, Francesca Perandin, Claudia Zanardello, Paola Rodari, Silvia Staffolani, Zeno Bisoffi
Lobomycosis is a chronic skin mycosis endemic in Amazon regions characterized by chronic nodular or keloidal lesions caused by Lacazia loboi , an uncultivable fungus. Imported cases in nonendemic countries are rare and diagnosed after years. We describe a case of lobomycosis in a healthy 55-year-old Italian traveler who had acquired the infection during 5-day-honeymoon in the Amazon region of Venezuela in 1999. Several weeks after return, he recalled pruritus and papular skin lesions on the left lower limb, subsequently evolving to a plaque-like lesion...
December 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28838445/blastomyces-dermatitidis-in-a-renal-transplant-recipient-a-case-report
#15
M Ben Salem, M Hamouda, M Mohamed, S Aloui, A Letaief, A Moussa, H Skhiri, A Zakahama, N Ben Dhia
Fungal infections have an important role in organ transplant recipients, and in some cases can be lethal. Blastomycosis is rare in kidney transplantation. We present a case of cutaneous blastomycosis in a kidney transplant recipient in Tunisia, a country outside the known endemic countries. This case, with the very uncommon and unexpected diagnosis of blastomycosis, demonstrates the diversity of infections in transplant recipients and reflects the importance of histologic and serologic tests in the immunocompromised patient...
September 2017: Transplantation Proceedings
https://www.readbyqxmd.com/read/28813733/disseminated-blastomycosis-mimicking-malignancy
#16
Jennifer L Hsu, B Joel Tjarks, Aaron Berg, Tony Oliver
Blastomycosis is an endemic fungal infection commonly found within the Mississippi and Ohio River basins and Great Lakes region. While patients typically present with acute pneumonia, Blastomyces dermatitidis has the potential to spread hematogenously, resulting in disseminated infection of multiple organs. In this report, we describe a 57-year-old male with disseminated blastomycosis acquired in South Dakota. The diagnostic evaluation was confounded by concern for malignancy given the involvement of multiple locations, including brain, lungs, adrenal glands, and testes...
April 2017: South Dakota Medicine: the Journal of the South Dakota State Medical Association
https://www.readbyqxmd.com/read/28806010/blastomycosis-and-histoplasmosis-in-a-patient-with-glioblastoma-receiving-temozolomide
#17
Aiham H Jbeli, John Yu
Malignant glioblastoma multiform (GBM) is the most common primary malignancy of the brain in the U.S. Temozolomide (TMZ) is the cornerstone of management along with surgical resection and radiotherapy. Because of the reduction in the CD4+ lymphocyte count as a side effect of TMZ use, this patient population is under risk for opportunistic infections like Pneumocystis jiroveci. A male patient with newly diagnosed glioblastoma multiform presented with non-productive cough and chest pain. Before presentation, the patient received the standard therapy including surgical resection, radiation and TMZ...
October 2016: South Dakota Medicine: the Journal of the South Dakota State Medical Association
https://www.readbyqxmd.com/read/28797487/clinical-manifestations-and-treatment-of-blastomycosis
#18
REVIEW
Joseph A McBride, Gregory M Gauthier, Bruce S Klein
The causal agents of blastomycosis, Blastomyces dermatitidis and Blastomyces gilchristii, belong to a group of thermally dimorphic fungi that can infect healthy and immunocompromised individuals. Following inhalation of mycelial fragments and spores into the lungs, Blastomyces spp convert into pathogenic yeast and evade host immune defenses to cause pneumonia and disseminated disease. The clinical spectrum of pulmonary blastomycosis is diverse. The diagnosis of blastomycosis requires a high degree of clinical suspicion and involves culture-based and non-culture-based fungal diagnostic tests...
September 2017: Clinics in Chest Medicine
https://www.readbyqxmd.com/read/28792123/fine-needle-aspiration-cytology-of-acute-blastomycosis-thyroiditis
#19
Nagarjun Rao, Sherri J Mann
No abstract text is available yet for this article.
December 2017: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/28721351/cerebral-epidural-abscess-secondary-to-blastomyces-masquerading-as-an-epidermoid-tumor
#20
Cody Doberstein, Abass Noor, David Choi, Jacob Smith, Darren Groh, Leonard Mermel, Curtis Doberstein
There have been infrequent reports of isolated central nervous system blastomycosis. We report a case of intracranial epidural abscess secondary to Blastomyces dermatitidis in a patient residing in Rhode Island with a history of remote travel to an endemic area. The clinical, radiographic, and pathologic features of this unique case are reviewed.
2017: Open Forum Infectious Diseases
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