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Blastomycosis

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https://www.readbyqxmd.com/read/28346820/blastomyces-dermatitidis-serine-protease-dipeptidyl-peptidase-iva-dppiva-cleaves-elr-cxc-chemokines-altering-their-effects-on-neutrophils
#1
Jenna Lorenzini, J Scott Fites, Jeniel Nett, Bruce S Klein
Blastomycosis elicits a pyogranulomatous inflammatory response, which involves a prominent recruitment of neutrophils to the site of infection. While neutrophils are efficiently recruited to the site of infection, this event is paradoxically coupled with the host's inability to control infection by Blastomyces dermatitidis, the causative agent. The mechanisms underlying this characteristic pyogranulomatous response and inability of neutrophils to kill the yeast are poorly understood. We recently reported that the fungal protease DppIVA promotes B...
March 27, 2017: Cellular Microbiology
https://www.readbyqxmd.com/read/28317569/oral-fungal-infections-diagnosis-and-management
#2
REVIEW
David R Telles, Niraj Karki, Michael W Marshall
Oral and maxillofacial fungal infections can appear in high-risk patients, including those immunocompromised. This article explores common oral manifestations of fungal infections in the oral cavity as primary lesions or as a result of disseminated disease. By far the most common oral fungal infection experienced in dentistry is oral candidiasis, which is reviewed in depth from simple oral infections to invasive candidiasis. The review aids the dental practitioner in understanding the full scope of Candida infections and other fungal infections...
April 2017: Dental Clinics of North America
https://www.readbyqxmd.com/read/28300442/an-atypical-case-of-mucocutaneous-blastomycosis-in-the-greater-toronto-area
#3
Annie Liu, Neil Shear, John Wong, Hagen B E Klieb
Blastomycosis is an uncommon infection caused by Blastomyces dermatitidis. While management is fairly straightforward, diagnosis can be quite challenging. We describe a case of a healthy 37-year-old man who presented with progressive mucocutaneous lesions, without lung or other systemic involvement. Treatment with itraconazole resulted in complete resolution of signs and symptoms. This case showcases the variety of blastomycosis clinical presentation and the importance of blastomycosis in the differential diagnosis of verrucous and papillomatous mucocutaneous lesions...
January 1, 2017: Journal of Cutaneous Medicine and Surgery
https://www.readbyqxmd.com/read/28291633/blastomycosis-during-pregnancy-a-case-report-and-review-of-the-literature
#4
REVIEW
Thomas Baker, Ami Patel, Pierre Halteh, Sima S Toussi, Patricia DeLaMora, Shari Lipner, Audrey N Schuetz, Barry Hartman
The diagnosis of blastomycosis during pregnancy is rare, but can carry significant clinical questions for both the infected mother and developing fetus. Furthermore, given its rarity, providers have little available data to help manage and counsel patients in this uncommon, yet serious, scenario. We present a case of blastomycosis in a woman at 38weeks' gestation and review all published cases of blastomycosis during pregnancy. It is our hope to provide a multidisciplinary understanding of the current knowledge surrounding the presentation, diagnosis, management, and outcome of this unusual infection...
February 27, 2017: Diagnostic Microbiology and Infectious Disease
https://www.readbyqxmd.com/read/28177861/disseminated-blastomycosis
#5
Anjum S Kaka, George A Sarosi
A 39-year-old man presented with acute hemoptysis and chills. Computed tomography (CT) of his chest showed an infiltrate in the right upper lobe (Panel A), and he was treated with levofloxacin. One month after this presentation, his 5-year-old son pulled on his left ring finger, which caused pain..
February 9, 2017: New England Journal of Medicine
https://www.readbyqxmd.com/read/28116230/cutaneous-blastomycosis-and-dermatophytic-pseudomycetoma-in-a-persian-cat-from-bangkok-thailand
#6
Lerpen Duangkaew, Lawan Larsuprom, Chaiyan Kasondorkbua, Charles Chen, Ariya Chindamporn
This is a case report of concurrent of blastomycosis and pseudomycetoma in a 3 year-old Persian cat from Bangkok, Thailand. Histopathology from antemortem and postmortem samples revealed blastomycosis and dermatophyte pseudomycetoma. The PCR analysis of the formalin-embedded tissue of antemortem sample confirmed that blastomycosis was caused by Blastomyces dermatitidis. Dermatophyte infection was caused by Microsporum canis. According to the author's knowledge, this is the first case of Blastomyces dermatitidis and dermatophyte pseudomycetoma in South-East Asia...
March 2017: Medical Mycology Case Reports
https://www.readbyqxmd.com/read/28033237/central-nervous-system-blastomycosis-in-children-a-case-report-and-review-of-the-literature
#7
Theresa Madigan, Yasaman Fatemi, Elitza S Theel, Amaran Moodley, Thomas G Boyce
We present a 7-year-old boy with chronic meningitis caused by Blastomyces dermatitidis. A review of the literature revealed 32 cases of CNS blastomycosis in children between 1983 and 2016, of which 18 represented parenchymal disease of the brain or spinal cord. Blastomycosis affecting the CNS is rare, but should be considered in children with chronic meningitis.
December 28, 2016: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/27891438/blastomycosis-like-pyoderma-a-rare-case-report
#8
Amrita A Hongal, Somashekar Gejje
Blastomycosis-like pyoderma is a rare, cutaneous bacterial infection of skin, seen in malnourished individuals, in a poor state of health and manifests as vegetating skin lesions. It is an unusual tissue reaction possibly to bacterial infection, the most common organism being Staphylococcus aureus. This case report is of a 35-year-old male who presented with thick verrucous surfaced plaques and papules on trunk and extremities since 2 months. Investigations revealed anaemia with hypochromasia, neutrophilic leucocytosis, hypo-proteinemia and hypo-albuminemia with reversal of A/G ratio...
October 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/27851437/1802-disseminated-blastomycosis-presenting-with-acute-neurologic-symptoms-due-to-cerebellar-abscesses
#9
Amir Tirmizi, Saira Butt
No abstract text is available yet for this article.
December 2016: Critical Care Medicine
https://www.readbyqxmd.com/read/27850591/953-outcomes-of-blastomycosis-requiring-invasive-mechanical-ventilation-a-national-analysis
#10
Mihir Shah, Gaurav Dagar, Amit Taneja, Gagan Kumar, Rahul Nanchal
No abstract text is available yet for this article.
December 2016: Critical Care Medicine
https://www.readbyqxmd.com/read/27837497/the-changing-epidemiology-of-invasive-fungal-infections
#11
David A Enoch, Huina Yang, Sani H Aliyu, Christianne Micallef
Invasive fungal infections (IFI) are an emerging problem worldwide with invasive candidiasis and candidemia responsible for the majority of cases. This is predominantly driven by the widespread adoption of aggressive immunosuppressive therapy among certain patient populations (e.g., chemotherapy, transplants) and the increasing use of invasive devices such as central venous catheters (CVCs). The use of new immune modifying drugs has also opened up an entirely new spectrum of patients at risk of IFIs. While the epidemiology of candida infections has changed in the last decade, with a gradual shift from C...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/27744308/ast-to-alt-ratio-is-elevated-in-disseminated-histoplasmosis-as-compared-to-localized-pulmonary-disease-and-other-endemic-mycoses
#12
Andrej Spec, Christopher R Barrios, Usama Ahmad, Laurie A Proia
Severe pulmonary or disseminated histoplasmosis often necessitates presumptive antifungal treatment while awaiting definitive diagnosis. Histoplasma antigen assays have improved sensitivity but results may lag up to 7 days. In order to increase diagnostic certainty, "soft clues" may be looked for in laboratory and radiologic data, such as elevated alkaline phosphatase or ferritin levels and findings of mediastinal adenopathy or hepatosplenomegaly. To determine if elevated aspartate aminotransferase (AST) to alanine aminotransferase (ALT) ratio is specific to histoplasmosis or a non-specific marker for disseminated fungal infection or sepsis in general, we retrospectively examined records of all patients diagnosed with an endemic fungal infection (EFI) at Rush University Medical Center from January of 1997 to October of 2012, and a cohort of septic patients with elevated liver enzymes...
October 14, 2016: Medical Mycology: Official Publication of the International Society for Human and Animal Mycology
https://www.readbyqxmd.com/read/27734587/canine-panuveitis-a-retrospective-evaluation-of-55-cases-2000-2015
#13
Benjamin E Bergstrom, Jean Stiles, Wendy M Townsend
OBJECTIVE: To determine the most common etiologies of panuveitis in a group of dogs, patient response to therapy, and visual outcome. DESIGN: Retrospective study. MATERIALS AND METHODS: Medical records of 55 dogs diagnosed with panuveitis at the Purdue University Veterinary Teaching Hospital between December 2000 and December 2015 were reviewed. Data collected included signalment, season of diagnosis, descriptions of ocular lesions, diagnostic testing, treatment protocols, etiologic diagnoses (when determined), and visual outcome...
October 12, 2016: Veterinary Ophthalmology
https://www.readbyqxmd.com/read/27699146/evidence-of-delayed-dissemination-or-re-infection-with-blastomyces-in-two-immunocompetent-hosts
#14
Jennifer L Anderson, Jennifer K Meece, Matthew C Hall, Holly M Frost
Relapse or recurrence of blastomycosis in patients is rare. Re-infection of a patient with blastomycosis has not been previously reported. In this report, we describe relapse or reinfection with Blastomyces in 2 immunocompetent patients. This is the first study in which genetic typing was performed on paired Blastomyces isolates from the same patient obtained months apart.
September 2016: Medical Mycology Case Reports
https://www.readbyqxmd.com/read/27691971/systemic-blastomycosis-in-a-captive-red-ruffed-lemur-varecia-rubra
#15
Michael F Rosser, Dana M Lindemann, Anne M Barger, Matthew C Allender, Shih-Hsuan Hsiao, Mark E Howes
A 5-yr-old, intact male red ruffed lemur ( Varecia rubra ) presented for evaluation as the result of a 1-wk history of lethargy and hyporexia. Physical examination findings included thin body condition, muffled heart sounds, harsh lung sounds, and liquid brown diarrhea. Complete blood count and serum biochemistry showed an inflammatory leukogram, mild hyponatremia, and mild hypochloremia. Orthogonal trunk radiographs revealed a severe alveolar pattern in the right cranial lung lobes with cardiac silhouette effacement...
September 2016: Journal of Zoo and Wildlife Medicine: Official Publication of the American Association of Zoo Veterinarians
https://www.readbyqxmd.com/read/27613208/mortality-from-fungal-diseases-in-the-us-air-force-from-1970-to-2013
#16
Richard K Kugblenu, Will K Reeves
We review a unique set of documents, death certificates, catalogued in the US Air Force Mortality Registry, which tracks deaths for current and retired Air Force service members. We screened the records for all deaths caused by fungal diseases between 1970 and 2013. There were 216 deaths caused by a variety of diseases such as aspergillosis, blastomycosis, candidiasis, coccidioidomycosis, cryptococcosis, histoplasmosis, mucormycosis, pneumocystosis, sporotrichosis, and zygomycosis. The single most common identified cause of death was opportunistic candidiasis...
October 2016: U.S. Army Medical Department Journal
https://www.readbyqxmd.com/read/27551850/blastomycosis-of-the-nose-a-case-report
#17
Thomas M Jetmore, Jennifer Phan, Abideen O Yekinni
Blastomyces dermatitidis is a thermally dimorphic fungus endemic to the North American soil near the Mississippi, Ohio, and St. Lawrence river valleys, as well as the Great Lakes Basin. It is responsible for blastomycosis, a systemic pyogranulomatous disease. Blastomycosis of the head and neck is decidedly uncommon and often mistaken for cancer. There are only 3 previous case reports of blastomycosis presenting as an intranasal lesion. We report the unusual case of a 24-year-old man with blastomycosis presenting with a 4-week history of a progressively enlarging intranasal mass who had complete resolution of symptoms after treatment with itraconazole and surgical excision of the lesion...
August 2016: Ear, Nose, & Throat Journal
https://www.readbyqxmd.com/read/27533292/case-233-blastomycosis
#18
Hans Mouser, Frank H Miller, Senta M Berggruen
History A 35-year-old man from the upper Midwest region of the United States who had no relevant medical history initially presented to an acute care clinic with multiple small tender skin lesions. His temperature was 38.1°C, and physical examination revealed several small fluctuant masses that were draining purulent material. Skin culture of one of the draining lesions was performed at this time, but there was no subsequent bacterial growth. A diagnosis of furunculosis was made, and Bactrim (sulfamethoxazole-trimethoprim; AR Scientific, Philadelphia, Pa) and a regimen of chlorhexidine washes were prescribed...
September 2016: Radiology
https://www.readbyqxmd.com/read/27419155/diagnostic-delay-and-antibiotic-overuse-in-acute-pulmonary-blastomycosis
#19
Jonathan D Alpern, Nathan C Bahr, Gabriela Vazquez-Benitez, David R Boulware, Jonathan S Sellman, George A Sarosi
The diagnosis of blastomycosis is often delayed. We identified 28 cases of pulmonary blastomycosis in a retrospective chart review. Most patients received multiple antibiotic courses before being diagnosed, and the sputum KOH smear was rarely used. Diagnostic delay can be decreased with higher suspicion for pulmonary blastomycosis and early use of the sputum KOH smear.
April 2016: Open Forum Infectious Diseases
https://www.readbyqxmd.com/read/27149459/management-and-outcomes-of-acute-respiratory-distress-syndrome-caused-by-blastomycosis-a-retrospective-case-series
#20
Ilan S Schwartz, John M Embil, Atul Sharma, Stephen Goulet, R Bruce Light
Acute respiratory distress syndrome (ARDS) is an uncommon, highly fatal, and poorly understood manifestation of blastomycosis. Optimal management remains unknown, including the roles of adjunctive corticosteroids and extracorporeal membrane oxygenation (ECMO).We conducted a retrospective chart review of patients with ARDS caused by blastomycosis, managed in intensive care units in Manitoba, Canada, from 1992 to 2014. ARDS was defined using the Berlin definition. Corticosteroid therapy was defined as ≥150 mg cortisol equivalent in 24 hours...
May 2016: Medicine (Baltimore)
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