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Horst Sievert

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https://www.readbyqxmd.com/read/28394759/combined-mitro-aortic-pathology-impact-of-previous-aortic-valve-replacement-upon-outcomes-of-mitra-clip-therapy
#1
Giuseppe D'Ancona, Stephan Kische, Jochen Senges, Taoufik Ouarrak, Miriam Puls, Raffi Bekeredjian, Horst Sievert, Erdal Safak, Jasmin Ortak, Alper Öner, Wolfgang Schillinger, Hüseyin Ince
AIMS: To identify the impact of previous aortic valve replacement (AVR) in Mitra-Clip (MC) patients. METHODS AND RESULTS: Data from the German Transcatheter Mitral Valve Interventions (TRAMI) registry were analyzed in light of previous AVR by means of either standard AVR (SAVR) or transcatheter AVR (TAVR). Out of 791 MC, 68 (8.6%) had been submitted to AVR (68.4% SAVR and 31.6% TAVR). AVR group was significantly older (77.2±8.0 years vs. 75.1±8.6 years; p<0...
April 11, 2017: EuroIntervention
https://www.readbyqxmd.com/read/28388746/-update-on-left-atrial-appendage-closure-2017
#2
Volker Schulze, Tobias Zeus, Horst Sievert
No abstract text is available yet for this article.
April 2017: Deutsche Medizinische Wochenschrift
https://www.readbyqxmd.com/read/28283511/independent-modular-filter-for-embolic-protection-in-carotid-stenting
#3
Dierk Scheinert, Bernhard Reimers, Alberto Cremonesi, Andrej Schmidt, Horst Sievert, Stefan Rohde, Joachim Schofer, Harald G Mudra, Marc Bosiers, Thomas Zeller, Andrea Pacchioni, Uri Rosenschein
BACKGROUND: Embolic protection during carotid artery stenting reduces the rate of thromboembolic events. The Wirion Embolic Protection System is used to deploy an independent distal filter using any 0.014″ guidewire. WISE study (Wirion Study Europe) evaluated the safety and performance of Wirion Embolic Protection System in patients undergoing carotid artery stenting. METHODS AND RESULTS: A prospective, multicenter, nonrandomized, open-label, single-arm study of carotid artery stenting in high surgical risk patients was performed...
March 2017: Circulation. Cardiovascular Interventions
https://www.readbyqxmd.com/read/28215464/patients-with-intracranial-bleeding-and-atrial-fibrillation-treated-with-left-atrial-appendage-occlusion-results-from-the-amplatzer-cardiac-plug-registry
#4
Apostolos Tzikas, Xavier Freixa, Laura Llull, Sameer Gafoor, Samera Shakir, Heyder Omran, George Giannakoulas, Sergio Berti, Gennaro Santoro, Joelle Kefer, Adel Aminian, Steffen Gloekler, Ulf Landmesser, Jens Erik Nielsen-Kudsk, Ignacio Cruz-Gonzalez, Prapa Kanagaratnam, Fabian Nietlispach, Reda Ibrahim, Horst Sievert, Wolfgang Schillinger, Jai-Wun Park, Bernhard Meier, Haralampos Karvounis
BACKGROUND: In patients with non-valvular atrial fibrillation (NVAF), intracranial bleeding (ICB) constitutes a very challenging situation in which the rate of both ischemic and hemorrhagic events is increased. In these patients, left atrial appendage occlusion (LAAO) might represent a very valid alternative. OBJECTIVES: To investigate the procedural safety and long-term outcome of patients undergoing LAAO therapy due to previous ICB. METHODS: Data from the Amplatzer Cardiac Plug multicenter registry on 1047 consecutive patients were analyzed...
February 13, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28089998/first-clinical-experience-with-targeted-renal-nerve-demodulation-trend-1-using-a-neurotropic-agent-for-the-treatment-of-sympathetic-hypertension
#5
Nicholas Kipshidze, Horst Sievert, Michael H Wholey, Konstantin Kipiani, Vakhtang Kipiani, Tea Mukhuradze, Mark Wholey, Emily Stein, K T Venkateswara Rao
AIMS: To evaluate the feasibility and safety of a novel targeted neuromodulatory treatment for sympathetic hypertension involving a one-time local injection of neurotropic agents near renal nerves. METHODS AND RESULTS: Seven patients suffering from uncontrolled hypertension per ESH-ESC guidelines were treated using a single dose of NW2013, a neurotropic Na+/K+ ATPase antagonist. A microneedle catheter was used to administer 1.2 mL of NW2013 (0.6 mL per artery) to the perivascular space surrounding renal arteries using percutaneous endovascular procedures under fluoroscopic guidance...
January 15, 2017: Journal of Invasive Cardiology
https://www.readbyqxmd.com/read/28089952/impact-of-tricuspid-valve-regurgitation-in-surgical-high-risk-patients-undergoing-mitraclip-implantation-results-from-the-trami-registry
#6
Daniel Kalbacher, Ulrich Schäfer, R Stephan von Bardeleben, Christine S Zuern, Raffi Bekeredjian, Taoufik Ouarrak, Horst Sievert, Georg Nickenig, Peter Boekstegers, Jochen Senges, Wolfgang Schillinger, Edith Lubos
AIMS: We sought to assess the impact of tricuspid regurgitation (TR) severity on patient outcome in a collective with relevant mitral regurgitation undergoing MitraClip implantation.. METHODS AND RESULTS: From August 2010 to July 2013, 766 patients (age 75.3±8.5 years, 61% male, median EuroSCORE 24.3%±18.4) were prospectively enrolled in the TRAMI registry and stratified by echocardiography into no/mild, moderate and severe TR. Overall, the mean number of implanted MitraClips was higher in patients with severe TR but increasing TR severity was not associated with procedural success...
February 3, 2017: EuroIntervention
https://www.readbyqxmd.com/read/27970251/tct-86-early-experience-with-the-trialign-system-for-transcatheter-tricuspid-valve-repair-a-multicenter-experience
#7
Ermela Yzeiraj, Horst Sievert, Georg Nickenig, Azeem Latib, Rebecca Hahn, Joachim Schofer
No abstract text is available yet for this article.
November 1, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27970217/tct-826-prospective-single-center-first-in-human-fih-clinical-trial-to-evaluate-the-safety-and-effectiveness-of-a-septal-occluder-with-bioresorbable-framework-in-patients-with-clinically-significant-atrial-septum-defect-asd-or-patent-foramen-ovale-pfo
#8
Björn Söderberg, Laura Vaskelyte, Sameer Gafoor, Ilona Hofmann, Andreas Mellmann, Jerome Bernhard, Horst Sievert
No abstract text is available yet for this article.
November 1, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27970208/tct-815-clinical-benefits-of-less-invasive-device-based-left-ventricular-reconstruction-a-hybrid-option-for-patients-with-ischemic-cardiomyopathy
#9
Christoph Schmitz, Mauri Biffi, Horst Sievert, Petr Neuzil, Salvatore Brugaletta, Christian Frerker, Azfar Zaman, Luigi Fiocca, Louis Labrousse, Lon Annest
No abstract text is available yet for this article.
November 1, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27970018/tct-640-percutaneous-mitral-valve-annuloplasty-patients-with-minimal-acute-reduction-in-mitral-regurgitation-improve-long-term-from-the-titan-ii-trial
#10
Horst Sievert, Steven Goldberg, Tomasz Siminiak, Hubertus Degen, Janusz Lipiecki, Michael Haude
No abstract text is available yet for this article.
November 1, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27970014/tct-639-the-impact-of-mitral-regurgitation-severity-on-efficacy-of-percutaneous-mitral-valve-annuloplasty-in-functional-mitral-regurgitation
#11
Horst Sievert, Michael Haude, Hubertus Degen, Janusz Lipiecki, Steven Goldberg, Tomasz Siminiak
No abstract text is available yet for this article.
November 1, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27969992/tct-615-do-patients-with-ckd-benefit-from-left-atrial-appendage-closure-laac-with-watchman-insights-from-protect-af
#12
Miguel Valderrabano, Matthew Price, Vivek Reddy, Maurice Buchbinder, David Holmes, Horst Sievert, Zoltan Turi, Nicole Gordon, Chris Mullin, Peter Sick, Patricia Best
No abstract text is available yet for this article.
November 1, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27969771/tct-42-transcatheter-echo-guided-mitral-valve-repair-with-neochord-implantation-for-posterior-leaflet-disease-results-from-neochord-independent-international-registry
#13
Andrea Colli, Laura Besola, Eleonora Bizzotto, Erica Manzan, Fabio Zucchetta, Demetrio Pittarello, Kestutis Rucinskas, Andrius Aidietis, Vilius Janusauskas, Diana Zakarkaite, Agne Drasutiene, Douglas Gibson, Bernd Danner, Horst Sievert, Katarzyna Kurnicka, Krzystof Wrobel, Stefano Salizzoni, Mauro Rinaldi, Krzystof Wrobel, Carlo Savini, Davide Pacini, Mariano Cefarelli, Gino Gerosa
No abstract text is available yet for this article.
November 1, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27890862/randomised-blinded-and-controlled-comparative-study-of-chemical-and-radiofrequency-based-renal-denervation-in-a-porcine-model
#14
Stefan Bertog, Tim A Fischel, Félix Vega, Vartan Ghazarossian, Atul Pathak, Laura Vaskelyte, Darrin Kent, Horst Sievert, Elena Ladich, Kazuyuki Yahagi, Renu Virmani
AIMS: The blood pressure-lowering effect of percutaneous renal denervation (RDN) is controversial. The success of RDN may be device-dependent. We sought to compare the efficacy of RDN by chemical neurolysis using alcohol (Peregrine System Infusion Catheter; Ablative Solutions, Inc., Menlo Park, CA, USA) to RDN by radiofrequency (RF) ablation with the single-electrode RF catheter (Symplicity Flex; Medtronic, Minneapolis, MN, USA) in a porcine model. METHODS AND RESULTS: This was a prospective, randomised, blinded study...
February 3, 2017: EuroIntervention
https://www.readbyqxmd.com/read/27745964/characterization-of-cerebrovascular-events-after-left-atrial-appendage-occlusion
#15
Xavier Freixa, Laura Llull, Sameer Gafoor, Ignacio Cruz-Gonzalez, Samera Shakir, Heyder Omran, Sergio Berti, Gennaro Santoro, Joelle Kefer, Ulf Landmesser, Jens Erik Nielsen-Kudsk, Prapa Kanagaratnam, Fabian Nietlispach, Steffen Gloekler, Adel Aminian, Paolo Danna, Marco Rezzaghi, Friederike Stock, Miroslava Stolcova, Luis Paiva, Marco Costa, Xavier Millán, Reda Ibrahim, Tobias Tichelbäcker, Wolfgang Schillinger, Jai-Wun Park, Horst Sievert, Bernhard Meier, Apostolos Tzikas
Cardioembolic strokes are generally more lethal and disabling than other source of strokes. Data from PROTECT AF (Watchman Left Atrial Appendage Closure Technology for Embolic Protection in Patients With Atrial Fibrillation) suggest that strokes after left atrial appendage occlusion (LAAO) with the Watchman device are less disabling than those in the warfarin group. No data assessing the severity of strokes after LAAO with the AMPLATZER Cardiac Plug (ACP) are available. The objective of the study was to evaluate the severity of cerebrovascular events after LAAO with the ACP in a population mostly characterized by an absolute or relative contraindication to oral anticoagulation...
September 15, 2016: American Journal of Cardiology
https://www.readbyqxmd.com/read/27628431/left-atrial-appendage-occlusion-rationale-evidence-devices-and-patient-selection
#16
REVIEW
Jonathan P Piccini, Horst Sievert, Manesh R Patel
Atrial fibrillation (AF) is a worldwide epidemic associated with significant morbidity and mortality, often due to disabling or fatal thromboembolic stroke. Oral anticoagulation is highly effective at preventing ischaemic stroke and improving all-cause survival in patients with non-valvular AF. Despite the efficacy of oral anticoagulation, many patients are not treated due to either absolute or perceived contraindications to therapy, including bleeding. Left atrial appendage (LAA) closure has emerged as a mechanical alternative to pharmacologic stroke prevention...
September 13, 2016: European Heart Journal
https://www.readbyqxmd.com/read/27616622/to-close-or-not-to-close-contemporary-indications-for-patent-foramen-ovale-closure
#17
REVIEW
Lucas S Zier, Horst Sievert, Vaikom S Mahadevan
Patent foramen ovale (PFO) is a common congenital cardiac abnormality and that has been associated with several disease processes including transient ischemic attacks (TIA), stroke, migraine headaches with aura, decompression sickness, platypnea-orthodeoxia syndrome, and shunt induced cyanosis. Controversy exists regarding closure of PFO as a therapeutic treatment modality for these disease processes. This review addresses the contemporary clinical indications for PFO closure. Areas covered: We conducted a comprehensive literature search of contemporary research studies focusing on randomized trials and meta-analyses comparing medical therapy and device closure of PFOs for the treatment of PFO associated clinical syndromes...
November 2016: Expert Review of Cardiovascular Therapy
https://www.readbyqxmd.com/read/27575279/impact-of-preprocedural-left-ventricular-ejection-fraction-on-1-year-outcomes-after-mitraclip-implantation-from-the-access-eu-phase-i-a-prospective-multicenter-nonrandomized-postapproval-study-of-the-mitraclip-therapy-in-europe
#18
Ulrich Schäfer, Francesco Maisano, Christian Butter, Olaf Franzen, Stephan Baldus, Jörg Hausleiter, Gian Paolo Ussia, Horst Sievert, Volker Geist, Julian Daniel Widder, Tiziano Moccetti, Wolfgang Schillinger
This report describes the 12-month outcomes of the a prospective, multicenter, nonrandomized post-approval study of the MitraClip therapy in Europe (ACCESS-EU postapproval study of MitraClip therapy) with respect to preprocedural left ventricular ejection fraction (LVEF). Transcatheter deployment of the MitraClip device may be considered for patients who are not suitable for conventional surgery. A total of 567 patients with significant mitral regurgitation (MR) underwent MitraClip therapy. Of those, 393 had functional MR (FMR) and were subdivided by preprocedural LVEF (A: 10% to 20%, B: >20% to 30%, C: >30% to 40%, D: >40%)...
September 15, 2016: American Journal of Cardiology
https://www.readbyqxmd.com/read/27540038/percutaneous-left-atrial-appendage-occlusion-the-munich-consensus-document-on-definitions-endpoints-and-data-collection-requirements-for-clinical-studies
#19
Apostolos Tzikas, David R Holmes, Sameer Gafoor, Carlos E Ruiz, Carina Blomström-Lundqvist, Hans-Christoph Diener, Riccardo Cappato, Saibal Kar, Randal J Lee, Robert A Byrne, Reda Ibrahim, Dhanunjaya Lakkireddy, Osama I Soliman, Michael Nabauer, Steffen Schneider, Johannes Brachmann, Jeffrey L Saver, Klaus Tiemann, Horst Sievert, A John Camm, Thorsten Lewalter
The increasing interest in left atrial appendage occlusion (LAAO) for ischaemic stroke prevention in atrial fibrillation (AF) fuels the need for more clinical data on the safety and effectiveness of this therapy. Besides an assessment of the effectiveness of the therapy in specific patients groups, comparisons with pharmacological stroke prophylaxis, surgical approaches, and other device-based therapies are warranted. This paper documents the consensus reached among clinical experts in relevant disciplines from Europe and North America, European cardiology professional societies, and representatives from the medical device industry regarding definitions for parameters and endpoints to be assessed in clinical studies...
January 2017: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/27493761/coronary-sinus-based-percutaneous-annuloplasty-as-treatment-for-functional-mitral-regurgitation-the-titan-ii-trial
#20
Janusz Lipiecki, Tomasz Siminiak, Horst Sievert, Jochen Müller-Ehmsen, Hubertus Degen, Justina C Wu, Christian Schandrin, Piotr Kalmucki, Ilona Hofmann, David Reuter, Steven L Goldberg, Michael Haude
OBJECTIVE: Functional (or secondary) mitral regurgitation (FMR) is associated with greater morbidity and worse outcomes in patients with congestive heart failure (CHF) and cardiomyopathy. The Carillon® Mitral Contour System® is a coronary sinus-based percutaneous therapy to reduce FMR. We evaluated the safety and efficacy of a modified version of the Carillon device in the treatment of patients with cardiomyopathy and FMR. METHODS: 36 patients with CHF, depressed left ventricular function (ejection fraction <40%) and at least moderate FMR underwent the Carillon device implant...
2016: Open Heart
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