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Horst Sievert

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https://www.readbyqxmd.com/read/27890862/randomized-blinded-and-controlled-comparative-study-of-chemical-and-radiofrequency-based-renal-denervation-in-a-porcine-model
#1
Stefan Bertog, Tim A Fischell, Félix Vega, Vartan Ghazarossian, Atul Pathak, Laura Vaskelyte, Darrin Kent, Horst Sievert, Elena Ladich, Kazuyuki Yahagi, Renu Virmani
AIMS: The blood pressure lowering effect of percutaneous renal denervation (RDN) is controversial. Success of RDN may be device-dependent. We sought to compare the efficacy of RDN by chemical neurolysis using alcohol (Peregrine System™ Infusion Catheter, Ablative Solutions, Inc. Menlo Park, CA, USA) to RDN by radiofrequency (RF) ablation with the single-electrode RF catheter (Symplicity™ Flex, Medtronic Inc., Minneapolis, MN, USA) in a porcine model. METHODS AND RESULTS: This was a prospective, randomized, blinded study...
November 29, 2016: EuroIntervention
https://www.readbyqxmd.com/read/27745964/characterization-of-cerebrovascular-events-after-left-atrial-appendage-occlusion
#2
Xavier Freixa, Laura Llull, Sameer Gafoor, Ignacio Cruz-Gonzalez, Samera Shakir, Heyder Omran, Sergio Berti, Gennaro Santoro, Joelle Kefer, Ulf Landmesser, Jens Erik Nielsen-Kudsk, Prapa Kanagaratnam, Fabian Nietlispach, Steffen Gloekler, Adel Aminian, Paolo Danna, Marco Rezzaghi, Friederike Stock, Miroslava Stolcova, Luis Paiva, Marco Costa, Xavier Millán, Reda Ibrahim, Tobias Tichelbäcker, Wolfgang Schillinger, Jai-Wun Park, Horst Sievert, Bernhard Meier, Apostolos Tzikas
Cardioembolic strokes are generally more lethal and disabling than other source of strokes. Data from PROTECT AF (Watchman Left Atrial Appendage Closure Technology for Embolic Protection in Patients With Atrial Fibrillation) suggest that strokes after left atrial appendage occlusion (LAAO) with the Watchman device are less disabling than those in the warfarin group. No data assessing the severity of strokes after LAAO with the AMPLATZER Cardiac Plug (ACP) are available. The objective of the study was to evaluate the severity of cerebrovascular events after LAAO with the ACP in a population mostly characterized by an absolute or relative contraindication to oral anticoagulation...
September 15, 2016: American Journal of Cardiology
https://www.readbyqxmd.com/read/27628431/left-atrial-appendage-occlusion-rationale-evidence-devices-and-patient-selection
#3
Jonathan P Piccini, Horst Sievert, Manesh R Patel
Atrial fibrillation (AF) is a worldwide epidemic associated with significant morbidity and mortality, often due to disabling or fatal thromboembolic stroke. Oral anticoagulation is highly effective at preventing ischaemic stroke and improving all-cause survival in patients with non-valvular AF. Despite the efficacy of oral anticoagulation, many patients are not treated due to either absolute or perceived contraindications to therapy, including bleeding. Left atrial appendage (LAA) closure has emerged as a mechanical alternative to pharmacologic stroke prevention...
September 13, 2016: European Heart Journal
https://www.readbyqxmd.com/read/27616622/to-close-or-not-to-close-contemporary-indications-for-patent-foramen-ovale-closure
#4
Lucas S Zier, Horst Sievert, Vaikom S Mahadevan
INTRODUCTION: Patent foramen ovale (PFO) is a common congenital cardiac abnormality and that has been associated with several disease processes including transient ischemic attacks (TIA), stroke, migraine headaches with aura, decompression sickness, platypnea-orthodeoxia syndrome, and shunt induced cyanosis. Controversy exists regarding closure of PFO as a therapeutic treatment modality for these disease processes. This review addresses the contemporary clinical indications for PFO closure...
September 10, 2016: Expert Review of Cardiovascular Therapy
https://www.readbyqxmd.com/read/27575279/impact-of-preprocedural-left-ventricular-ejection-fraction-on-1-year-outcomes-after-mitraclip-implantation-from-the-access-eu-phase-i-a-prospective-multicenter-nonrandomized-postapproval-study-of-the-mitraclip-therapy-in-europe
#5
Ulrich Schäfer, Francesco Maisano, Christian Butter, Olaf Franzen, Stephan Baldus, Jörg Hausleiter, Gian Paolo Ussia, Horst Sievert, Volker Geist, Julian Daniel Widder, Tiziano Moccetti, Wolfgang Schillinger
This report describes the 12-month outcomes of the a prospective, multicenter, nonrandomized post-approval study of the MitraClip therapy in Europe (ACCESS-EU postapproval study of MitraClip therapy) with respect to preprocedural left ventricular ejection fraction (LVEF). Transcatheter deployment of the MitraClip device may be considered for patients who are not suitable for conventional surgery. A total of 567 patients with significant mitral regurgitation (MR) underwent MitraClip therapy. Of those, 393 had functional MR (FMR) and were subdivided by preprocedural LVEF (A: 10% to 20%, B: >20% to 30%, C: >30% to 40%, D: >40%)...
September 15, 2016: American Journal of Cardiology
https://www.readbyqxmd.com/read/27540038/percutaneous-left-atrial-appendage-occlusion-the-munich-consensus-document-on-definitions-endpoints-and-data-collection-requirements-for-clinical-studies
#6
Apostolos Tzikas, David R Holmes, Sameer Gafoor, Carlos E Ruiz, Carina Blomström-Lundqvist, Hans-Christoph Diener, Riccardo Cappato, Saibal Kar, Randal J Lee, Robert A Byrne, Reda Ibrahim, Dhanunjaya Lakkireddy, Osama I Soliman, Michael Nabauer, Steffen Schneider, Johannes Brachmann, Jeffrey L Saver, Klaus Tiemann, Horst Sievert, A John Camm, Thorsten Lewalter
The increasing interest in left atrial appendage occlusion (LAAO) for ischaemic stroke prevention in atrial fibrillation (AF) fuels the need for more clinical data on the safety and effectiveness of this therapy. Besides an assessment of the effectiveness of the therapy in specific patients groups, comparisons with pharmacological stroke prophylaxis, surgical approaches, and other device-based therapies are warranted. This paper documents the consensus reached among clinical experts in relevant disciplines from Europe and North America, European cardiology professional societies, and representatives from the medical device industry regarding definitions for parameters and endpoints to be assessed in clinical studies...
August 18, 2016: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/27493761/coronary-sinus-based-percutaneous-annuloplasty-as-treatment-for-functional-mitral-regurgitation-the-titan-ii-trial
#7
Janusz Lipiecki, Tomasz Siminiak, Horst Sievert, Jochen Müller-Ehmsen, Hubertus Degen, Justina C Wu, Christian Schandrin, Piotr Kalmucki, Ilona Hofmann, David Reuter, Steven L Goldberg, Michael Haude
OBJECTIVE: Functional (or secondary) mitral regurgitation (FMR) is associated with greater morbidity and worse outcomes in patients with congestive heart failure (CHF) and cardiomyopathy. The Carillon® Mitral Contour System® is a coronary sinus-based percutaneous therapy to reduce FMR. We evaluated the safety and efficacy of a modified version of the Carillon device in the treatment of patients with cardiomyopathy and FMR. METHODS: 36 patients with CHF, depressed left ventricular function (ejection fraction <40%) and at least moderate FMR underwent the Carillon device implant...
2016: Open Heart
https://www.readbyqxmd.com/read/27466274/initial-experience-using-the-gore-embolic-filter-in-carotid-interventions
#8
Marius Hornung, Jennifer Franke, Stefan C Bertog, Sameer Gafoor, Iris Grunwald, Horst Sievert
BACKGROUND: This is the first clinical report on experience in the use of the Gore embolic filter in carotid interventions. It was designed as a guidewire and embolic protection system in carotid, peripheral, and coronary interventions. The ability to capture debris is driven by the frame of the filter, which is designed to improve vessel wall apposition and allows a short landing zone. METHODS: We report the results of the first 20 consecutive patients undergoing carotid artery stenting using the Gore embolic filter in our institution...
August 2016: Journal of Invasive Cardiology
https://www.readbyqxmd.com/read/27372022/a-bicuspid-aortic-valve-imaging-classification-for-the-tavr-era
#9
Hasan Jilaihawi, Mao Chen, John Webb, Dominique Himbert, Carlos E Ruiz, Josep Rodés-Cabau, Gregor Pache, Antonio Colombo, Georg Nickenig, Michael Lee, Corrado Tamburino, Horst Sievert, Yigal Abramowitz, Giuseppe Tarantini, Faisal Alqoofi, Tarun Chakravarty, Mohammad Kashif, Nobuyuki Takahashi, Yoshio Kazuno, Yoshio Maeno, Hiroyuki Kawamori, Alaide Chieffo, Philipp Blanke, Danny Dvir, Henrique Barbosa Ribeiro, Yuan Feng, Zhen-Gang Zhao, Jan-Malte Sinning, Chad Kliger, Gennaro Giustino, Basia Pajerski, Sebastiano Imme, Eberhard Grube, Jonathon Leipsic, Alec Vahanian, Iassen Michev, Vladimir Jelnin, Azeem Latib, Wen Cheng, Raj Makkar
OBJECTIVES: This study sought to evaluate transcatheter aortic valve replacement (TAVR) in bicuspid aortic valve (BAV) aortic stenosis (AS), with a particular emphasis on TAVR-directed bicuspid aortic valve imaging (BAVi) of morphological classification. BACKGROUND: TAVR has been used to treat BAV-AS but with heterogeneous outcomes and uncertainty regarding the relevance of morphology. METHODS: In 14 centers in the United States, Canada, Europe, and Asia, 130 BAV-AS patients underwent TAVR...
June 29, 2016: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/27290686/impact-on-outcome-of-different-types-of-carotid-stent-results-from-the-european-registry-of-carotid-artery-stenting
#10
Eugenio Stabile, Giuseppe Giugliano, Alberto Cremonesi, Marc Bosiers, Bernhard Reimers, Carlo Setacci, Piergiorgio Cao, Andrej Schmidt, Horst Sievert, Patrick Peeters, Dimitrios Nikas, Anna Sannino, Gianmarco de Donato, Giambattista Parlani, Fausto Castriota, Marius Hornung, Paolo Rubino, Giovanni Esposito, Tullio Tesorio
AIMS: Conflicting data exist on the impact on outcome of the use of different stent types during carotid artery stenting (CAS). The aim of this study was to evaluate clinical outcomes according to different carotid stent design among the population of the European Registry of Carotid Artery Stenting (ERCAS). METHODS AND RESULTS: The present study was conducted in 1,604 patients who underwent neuroprotected CAS in ERCAS. All types of commercially available carotid stent were used...
June 12, 2016: EuroIntervention
https://www.readbyqxmd.com/read/27290685/gender-in-the-access-eu-registry-a-prospective-multicentre-non-randomised-post-market-approval-study-of-mitraclip%C3%A2-therapy-in-europe
#11
Sameer Gafoor, Horst Sievert, Francesco Maisano, Stephan Baldus, Ulrich Schaefer, Joerg Hausleiter, Christian Butter, Gian Paolo Ussia, Volker Geist, Julian D Widder, Tiziano Moccetti, Wolfgang Schillinger, Olaf Franzen
AIMS: Gender has been an important factor in outcomes after mitral valve surgery; however, its effect on percutaneous mitral valve repair is not well known. We aimed to report the effect of gender on outcomes in a large European prospective, multicentre, non-randomised post-approval study of percutaneous mitral valve repair. METHODS AND RESULTS: Two hundred and five female and 362 male patients with significant mitral regurgitation underwent percutaneous repair at 14 European sites from October 2008 to April 2011...
June 12, 2016: EuroIntervention
https://www.readbyqxmd.com/read/27258944/incidence-and-clinical-impact-of-stroke-complicating-transcatheter-aortic-valve-implantation-results-from-the-german-tavi-registry
#12
Nicolas Werner, Uwe Zeymer, Steffen Schneider, Timm Bauer, Ulrich Gerckens, Axel Linke, Christian Hamm, Horst Sievert, Holger Eggebrecht, Und Ralf Zahn
BACKGROUND: Transcatheter aortic valve implantation (TAVI) has emerged as a safe and effective treatment for patients with severe, symptomatic aortic valve stenosis at high surgical risk over the last years. However, besides its minimal invasive character, TAVI still is an invasive procedure usually performed in a population, carrying a substantial risk for vascular complications, like stroke. Stroke is known to be a rare but serious complication of transvascular interventions in clinical practice, which is associated with high morbidity and mortality rates...
June 3, 2016: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/27188965/patent-foramen-ovale
#13
Shunichi Homma, Steven R Messé, Tatjana Rundek, Yee-Ping Sun, Jennifer Franke, Karina Davidson, Horst Sievert, Ralph L Sacco, Marco R Di Tullio
Patent foramen ovale (PFO) is the most common congenital heart abnormality of fetal origin and is present in approximately ∼25% of the worldwide adult population. PFO is the consequence of failed closure of the foramen ovale, a normal structure that exists in the fetus to direct blood flow directly from the right to the left atrium, bypassing the pulmonary circulation. PFO has historically been associated with an increased risk of stroke, the mechanism of which has been attributed to the paradoxical embolism of venous thrombi that shunt through the PFO directly to the left atrium...
January 21, 2016: Nature Reviews. Disease Primers
https://www.readbyqxmd.com/read/27180304/the-clear-road-study-evaluation-of-a-new-dual-layer-micromesh-stent-system-for-the-carotid-artery
#14
Marc Bosiers, Koen Deloose, Giovanni Torsello, Dierk Scheinert, Lieven Maene, Patrick Peeters, Stefan Müller-Hülsbeck, Horst Sievert, Ralf Langhoff, Michel Bosiers, Carlo Setacci
AIMS: The aim of this study was to evaluate the 30-day clinical outcome of treatment using the Roadsaver carotid stent in non-consecutive subjects at high risk for carotid endarterectomy requiring revascularisation. METHODS AND RESULTS: The CLEAR-ROAD study is a prospective, multinational, single-arm, physician-initiated study planned to include 100 patients in nine centres in Belgium, Italy and Germany. The primary endpoint was the 30-day rate of major adverse events (MAE), defined as the cumulative incidence of any death, stroke or myocardial infarction (MI)...
2016: EuroIntervention
https://www.readbyqxmd.com/read/27173874/how-should-i-treat-budd-chiari-syndrome-after-liver-transplantation-with-inferior-vena-cava-occlusion
#15
Saima Karim, Victor Lucas, Anil Verma, Nigel Girgrah, Stephen Ramee, Fausto Castriota, Antonio Micari, Giuseppe Roscitano, Francesco Spinelli, Sameer Gafoor, Abdul Haseeb, Asad Khan, Jennifer Franke, Predrag Matic, Markus Reinartz, Stefan Bertog, Laura Vaskelyte, Ilona Hofmann, Horst Sievert
No abstract text is available yet for this article.
May 17, 2016: EuroIntervention
https://www.readbyqxmd.com/read/27173870/percutaneous-left-atrial-appendage-occlusion-the-munich-consensus-document-on-definitions-endpoints-and-data-collection-requirements-for-clinical-studies
#16
Apostolos Tzikas, David R Holmes, Sameer Gafoor, Carlos E Ruiz, Carina Blomström-Lundqvist, Hans-Christoph Diener, Riccardo Cappato, Saibal Kar, Randal J Lee, Robert A Byrne, Reda Ibrahim, Dhanunjaya Lakkireddy, Osama I Soliman, Michael Näbauer, Steffen Schneider, Johannes Brachman, Jeffrey L Saver, Klaus Tiemann, Horst Sievert, A John Camm, Thorsten Lewalter
The increasing interest in left atrial appendage occlusion (LAAO) for ischaemic stroke prevention in atrial fibrillation (AF) fuels the need for more clinical data on the safety and effectiveness of this therapy. Besides an assessment of the effectiveness of the therapy in specific patient groups, comparisons with pharmacological stroke prophylaxis, surgical approaches and other device-based therapies are warranted. This paper documents the consensus reached among clinical experts in relevant disciplines from Europe and North America, European cardiology professional societies and representatives from the medical device industry regarding definitions for parameters and endpoints to be assessed in clinical studies...
May 17, 2016: EuroIntervention
https://www.readbyqxmd.com/read/27150168/cardioembolic-stroke-and-postmyocardial-infarction-stroke
#17
REVIEW
Marius Hornung, Jennifer Franke, Sameer Gafoor, Horst Sievert
Ischemic stroke following acute myocardial infarction (AMI) is a rare but serious complication due to left ventricular thrombus formation and atrial fibrillation. Early revascularization of the culprit coronary lesion is essential. Treatment trends may affect the risk. Conversely, the greater use of antiplatelet agents to reduce the risk of ischemic stroke could increase the risk of hemorrhagic stroke. The risk of stroke after AMI has decreased significantly with more use of percutaneous coronary intervention and antithrombotic therapies in the acute setting, and statins, antihypertensive medications, and dual antiplatelet therapy as secondary prevention strategies...
May 2016: Cardiology Clinics
https://www.readbyqxmd.com/read/27128539/left-atrial-appendage-ligation-with-the-next-generation-lariat-suture-delivery-device-early-clinical-experience
#18
Krzysztof Bartus, Sameer Gafoor, David Tschopp, John P Foran, Roland Tilz, Tom Wong, Dhanunjaya Lakkireddy, Horst Sievert, Randall J Lee
BACKGROUND: The purpose of the study was to determine the efficacy and safety of left atrial appendage (LAA) closure with a micropuncture pericardial access approach and the new LARIAT(+) suture delivery device. METHODS: Seventy-two patients with atrial fibrillation were enrolled to undergo telescopic micropuncture pericardial access and percutaneous ligation of the LAA with the LARIAT(+) device. LAA closure was confirmed with transesophageal echocardiography (TEE) and contrast fluoroscopy immediately, then with TEE at 30days and 90days post-LAA ligation...
July 15, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/27107315/left-atrial-appendage-occlusion-with-the-amplatzer-amulet-device-an-expert-consensus-step-by-step-approach
#19
Apostolos Tzikas, Sameer Gafoor, David Meerkin, Xavier Freixa, Ignacio Cruz-Gonzalez, Thorsten Lewalter, Jacqueline Saw, Sergio Berti, Jens Erik Nielsen-Kudsk, Reda Ibrahim, Dhanunjaya Lakkireddy, Vincent Paul, Dabit Arzamendi, Fabian Nietlispach, Stephen G Worthley, David Hildick-Smith, Jean Benoit Thambo, Claudio Tondo, Adel Aminian, Zbigniew Kalarus, Boris Schmidt, Lars Sondergaard, Joelle Kefer, Bernhard Meier, Jai-Wun Park, Horst Sievert, Heyder Omran
AIMS: This document aims to describe a standardised methodology for performing left atrial appendage occlusion (LAAO) using the AMPLATZER Amulet device, and to provide useful tips and tricks for operators with different levels of experience. METHODS AND RESULTS: Physicians who are experts in LAAO and had personal clinical experience with the AMPLATZER Amulet device were asked to contribute in the preparation of this consensus document. Twenty-seven physicians (20 interventional cardiologists and 7 electrophysiologists) from 14 different countries reviewed the manuscript...
April 20, 2016: EuroIntervention
https://www.readbyqxmd.com/read/27056117/percutaneous-left-atrial-appendage-occlusion-in-2016
#20
EDITORIAL
Apostolos Tzikas, Horst Sievert, David R Holmes
No abstract text is available yet for this article.
April 2016: EuroIntervention
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