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MULTICENTER STUDY
Marianna Adamo, Giulio Russo, Matteo Pagnesi, Edoardo Pancaldi, Hannes Alessandrini, Martin Andreas, Luigi P Badano, Daniel Braun, Kim A Connelly, Paolo Denti, Rodrigo Estevez-Loureiro, Neil Fam, Mara Gavazzoni, Rebecca T Hahn, Claudia Harr, Joerg Hausleiter, Dominique Himbert, Daniel Kalbacher, Edwin Ho, Azeem Latib, Edith Lubos, Sebastian Ludwig, Laura Lupi, Philipp Lurz, Vanessa Monivas, Georg Nickenig, Daniela Pedicino, Giovanni Pedrazzini, Alberto Pozzoli, Denise Pires Marafon, Roberta Pastorino, Fabien Praz, Joseph Rodes-Cabau, Christian Besler, Anne Rebecca Schöber, Joachim Schofer, Andrea Scotti, Kerstin Piayda, Horst Sievert, Gilbert H L Tang, Alessandro Sticchi, David Messika-Zeitoun, Holger Thiele, Florian Schlotter, Ralph Stephan von Bardeleben, John Webb, Julien Dreyfus, Stephan Windecker, Martin Leon, Francesco Maisano, Marco Metra, Maurizio Taramasso
BACKGROUND: Data on the prognostic role of the TRI-SCORE in patients undergoing transcatheter tricuspid valve intervention (TTVI) are limited. OBJECTIVES: The aim of this study was to evaluate the performance of the TRI-SCORE in predicting outcomes of patients undergoing TTVI. METHODS: TriValve (Transcatheter Tricuspid Valve Therapies) is a large multicenter multinational registry including patients undergoing TTVI. The TRI-SCORE is a risk model recently proposed to predict in-hospital mortality after tricuspid valve surgery...
April 8, 2024: JACC. Cardiovascular Interventions
#2
JOURNAL ARTICLE
Huiqi Zhai, Liang Kang, Yihua Li, Xinjun Zhao, Qingmin Chu, Rong Li
BACKGROUND: Atrial fibrillation is the most common cardiac arrhythmia, affecting 32 million individuals worldwide. Although atrial fibrillation has been studied for decades, a comprehensive analysis using bibliometrics has not been performed for atrial fibrillation-left atrial appendage occlusion (LAAO). Therefore, we analyzed the scientific outputs of global LAAO research and explored the current research status and hotpots from 1994 to 2022. METHODS: We searched the Web of Science core collection for publications related to LAAO that were published between 1994 and 2022...
April 5, 2024: Medicine (Baltimore)
#3
JOURNAL ARTICLE
Sophie Eppinger, Kerstin Piayda, Roberto Galea, Marcus Sandri, Moniek Maarse, Ahmet Güner, Can Y Karabay, Ashish Pershad, Wern Y Ding, Adel Aminian, Ibrahim Akin, Karapet V Davtyan, Ivan A Chugunov, Eloi Marijon, Liesbeth Rosseel, Thomas Robert Schmidt, Nicolas Amabile, Kasper Korsholm, Juha Lund, Enio Guerios, Ignacio J Amat-Santos, Giacomo Boccuzzi, Christopher R Ellis, Avi Sabbag, Henning Ebelt, Brian Clapp, Hana Vaknin Assa, Amos Levi, Jakob Ledwoch, Sonja Lehmann, Oh-Hyun Lee, George Mark, Wendy Schell, Domenico G Della Rocca, Andrea Natale, Ole de Backer, Joelle Kefer, Pablo P Esteban, Mark Abelson, Pradhum Ram, Pamela Moceri, Jose G Galache Osuna, Xavier Millán Alvarez, Ignacio Cruz-Gonzalez, Tom de Potter, Moubarak Ghassan, Andrey Osadchiy, Weita Chen, Sandeep K Goyal, Francesco Giannini, Máximo Rivero-Ayerza, Shazia Afzal, Christian Jung, Carsten Skurk, Martin Langel, Mark Spence, Evgeny Merkulov, Mathieu Lempereur, Seung Y Shin, Jules Mesnier, Heather L McKinney, Brian T Schuler, Sebastien Armero, Livia Gheorghe, Marco B M Ancona, Lino Santos, Jacques Mansourati, Luis Nombela-Franco, Francesco Nappi, Michael Kühne, Achille Gaspardone, Jesper van der Pals, Matteo Montorfano, Juan Fernández-Armenta, James E Harvey, Josep Rodés-Cabau, Norbert Klein, Sajjad A Sabir, Jung-Sun Kim, Stephane Cook, Ran Kornowski, Antti Saraste, Jens E Nielsen-Kudsk, Dhiraj Gupta, Lucas Boersma, Lorenz Räber, Kolja Sievert, Horst Sievert, Stefan Bertog
BACKGROUND: Left atrial appendage (LAA) occluder embolization is an infrequent but serious complication. OBJECTIVES: We aim to describe timing, management and clinical outcomes of device embolization in a multi-center registry. METHODS: Patient characteristics, imaging findings and procedure and follow-up data were collected retrospectively. Device embolizations were categorized according to 1) timing 2) management and 3) clinical outcomes...
February 28, 2024: Cardiovascular Revascularization Medicine: Including Molecular Interventions
#4
JOURNAL ARTICLE
Giulio Russo, Rebecca T Hahn, Hannes Alessandrini, Martin Andreas, Luigi P Badano, Daniel Braun, Kim A Connelly, Paolo Denti, Rodrigo Estevez-Loureiro, Neil Fam, Mara Gavazzoni, Joerg Hausleiter, Dominique Himbert, Daniel Kalbacher, Azeem Latib, Edith Lubos, Sebastian Ludwig, Philipp Lurz, Vanessa Monivas, Georg Nickenig, Daniela Pedicino, Giovanni Pedrazzini, Alberto Pozzoli, Fabien Praz, Joseph Rodes-Cabau, Karl-Philipp Rommel, Joachim Schofer, Horst Sievert, Gilbert Tang, Holger Thiele, Matthias Unterhuber, Ralph Stephan von Bardeleben, John Webb, Stephan Windecker, Martin Leon, Francesco Maisano, Maurizio Taramasso
AIMS: T-TEER is an effective therapy for the treatment of tricuspid regurgitation (TR). However, the effects of leaflets clipping on tricuspid valve annulus (TA) have not been investigated in detail. The aim of this study is to investigate the effects of tricuspid transcatheter edge-to-edge repair (T-TEER) on TA diameter. METHODS AND RESULTS: The TriValve registry (Transcatheter Tricuspid Valve Therapies, NCT03416166) collected 556 patients from 22 European and North American centres undergoing transcatheter tricuspid valve interventions from 2016 to 2022...
March 2, 2024: International Journal of Cardiology
#5
JOURNAL ARTICLE
Adam Mazurek, Krzysztof Malinowski, Pasqualino Sirignano, Ralf Kolvenbach, Laura Capoccia, Gianmarco DE Donato, Isabelle VAN Herzeele, Adnan H Siddiqui, Tomaso Castrucci, Lukasz Tekieli, Matteo Stefanini, Christian Wissgott, Kenneth Rosenfield, D Christopher Metzger, Kenneth Snyder, Andrey Karpenko, Waclaw Kuczmik, Eugenio Stabile, Magdalena Knapik, Renato Casana, Piotr Pieniazek, Anna Podlasek, Maurizio Taurino, Joachim Schofer, Alberto Cremonesi, Horst Sievert, Andrej Schmidt, Iris Q Grunwald, Francesco Speziale, Carlo Setacci, Piotr Musialek
INTRODUCTION: Meta-analyses and emerging randomized data indicate that second-generation ('mesh') carotid stents (SGS) may improve outcomes versus conventional (single-layer) stents but clinically-relevant differences in individual SGS-type performance have been identified. No comparisons exist for SGS versus carotid endarterectomy (CEA). EVIDENCE ACQUISITION: Thirty-day death (D), stroke (S), myocardial infarction (M), and 12-month ipsilateral stroke and restenosis in SGS studies were meta-analyzed (random effect model) against CEA outcomes...
December 2023: Journal of Cardiovascular Surgery
#6
JOURNAL ARTICLE
Uzair Ansari, Johannes Brachmann, Thorsten Lewalter, Uwe Zeymer, Horst Sievert, Jakob Ledwoch, Volker Geist, Matthias Hochadel, Steffen Schneider, Jochen Senges, Ibrahim Akin, Christian Fastner
BACKGROUND: Interventional left atrial appendage occlusion (LAAO) mitigates the risk of thromboembolic events in nonvalvular atrial fibrillation (AF) patients with contraindication for long-term oral anticoagulation (OAC). Patients with prior stroke have a relevantly increased risk of recurrent stroke, so the effectiveness of LAAO could be reduced in this specific very high-risk patient group. AIM: This sub-study of the LAARGE registry investigates the effectiveness and safety of LAAO for secondary prevention in nonvalvular AF patients with a history of stroke...
January 31, 2024: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
#7
MULTICENTER STUDY
Jules Mesnier, Trevor Simard, Richard G Jung, Kyle R Lehenbauer, Kerstin Piayda, Radoslaw Pracon, Gregory G Jackson, Eduardo Flores-Umanzor, Laurent Faroux, Kasper Korsholm, Julian K R Chun, Shaojie Chen, Moniek Maarse, Kristi Montrella, Zakeih Chaker, Jocelyn N Spoon, Luigi E Pastormerlo, Felix Meincke, Abhishek C Sawant, Carmen M Moldovan, Mohammed Qintar, Mehmet K Aktas, Luca Branca, Andrea Radinovic, Pradhum Ram, Rayan S El-Zein, Thomas Flautt, Wern Yew Ding, Bassel Sayegh, Tomás Benito-González, Oh-Hyun Lee, Solomon O Badejoko, Christina Paitazoglou, Nabeela Karim, Ahmed M Zaghloul, Himanshu Agarwal, Rachel M Kaplan, Oluseun Alli, Aamir Ahmed, Hussam S Suradi, Bradley P Knight, Venkata M Alla, Sidakpal S Panaich, Tom Wong, Martin W Bergmann, Rashaad Chothia, Jung-Sun Kim, Armando Pérez de Prado, Raveen Bazaz, Dhiraj Gupta, Miguel Valderrábano, Carlos E Sanchez, Mikhael F El Chami, Patrizio Mazzone, Marianna Adamo, Fred Ling, Dee Dee Wang, William O'Neill, Wojtek Wojakowski, Ashish Pershad, Sergio Berti, Daniel B Spoon, Akram Kawsara, George Jabbour, Lucas V A Boersma, Boris Schmidt, Jens Erik Nielsen-Kudsk, Xavier Freixa, Christopher R Ellis, Laurent Fauchier, Marcin Demkow, Horst Sievert, Michael L Main, Benjamin Hibbert, David R Holmes, Mohamad Alkhouli, Josep Rodés-Cabau
BACKGROUND: Scarce data exist on the evolution of device-related thrombus (DRT) after left atrial appendage closure (LAAC). OBJECTIVES: This study sought to assess the incidence, predictors, and clinical impact of persistent and recurrent DRT in LAAC recipients. METHODS: Data were obtained from an international multicenter registry including 237 patients diagnosed with DRT after LAAC. Of these, 214 patients with a subsequent imaging examination after the initial diagnosis of DRT were included...
November 27, 2023: JACC. Cardiovascular Interventions
#8
JOURNAL ARTICLE
Giulio Russo, Luigi P Badano, Marianna Adamo, Hannes Alessandrini, Martin Andreas, Daniel Braun, Kim A Connelly, Paolo Denti, Rodrigo Estevez-Loureiro, Neil Fam, Mara Gavazzoni, Rebecca T Hahn, Claudia Harr, Joerg Hausleiter, Dominique Himbert, Daniel Kalbacher, Edwin Ho, Azeem Latib, Edith Lubos, Sebastian Ludwig, Philipp Lurz, Vanessa Monivas, Georg Nickenig, Daniela Pedicino, Giovanni Pedrazzini, Alberto Pozzoli, Denise Pires Marafon, Roberta Pastorino, Fabien Praz, Joseph Rodes-Cabau, Christian Besler, Joachim Schofer, Andrea Scotti, Kerstin Piayda, Horst Sievert, Gilbert H L Tang, Holger Thiele, Florian Schlotter, Ralph Stephan von Bardeleben, John Webb, Stephan Windecker, Martin Leon, Francesco Maisano, Marco Metra, Maurizio Taramasso
BACKGROUND: Secondary or functional tricuspid regurgitation (STR) is the most common phenotype of tricuspid regurgitation (TR) with atrial STR (ASTR) and ventricular STR (VSTR) being recently identified as two distinct entities. Data on tricuspid transcatheter edge-to-edge repair (T-TEER) in patients with STR according to phenotype (i.e. ASTR vs VSTR) are lacking. OBJECTIVES: The aim of this study was to assess characteristics and outcomes of patients with ASTR vs VSTR undergoing T-TEER...
October 31, 2023: European Journal of Heart Failure
#9
JOURNAL ARTICLE
Marat Yildiz, Michael Haude, Horst Sievert, Stephan Fichtlscherer, Ralf Lehmann, Norbert Klein, Klaus Witte, Hubertus Degen, Dietrich Pfeiffer, Steven L Goldberg
BACKGROUND: The Carillon® Mitral Contour System® has been studied in 4 prospective controlled studies in the treatment of functional mitral regurgitation (FMR) where it has been found to reduce mitral regurgitation, reduce left ventricular and atrial volumes, and be associated with improvements in clinical parameters. AIMS: The CINCH post-market registry is designed to evaluate immediate, mid-term and long-term outcomes from a post-approval study of the Carillon® device evaluated in real-world practice...
September 23, 2023: Cardiovascular Revascularization Medicine: Including Molecular Interventions
#10
JOURNAL ARTICLE
Mengxuan Zou, Donglin Zhuang, Horst Sievert, Yat-Yin Lam, Guangzhi Zhao, Wenbin Ouyang, Fengwen Zhang, Fang Fang, Deyuan Zhang, Anning Li, Xiangbin Pan
BACKGROUND: Most patients undergoing left atrial appendage closure (LAAC) are older adult individuals with atrial fibrillation (AF) and many comorbidities, which may elevate the risk for complications associated with contrast agents with the fluoroscopic image-guided procedure. This retrospective cohort study of patients with AF at high risk for use of contrast agents compared the feasibility and safety of LAAC using percutaneous and non-fluoroscopic procedure with transesophageal echocardiography (TEE) as the only image guidance relative to those under fluoroscopic image guidance...
September 1, 2023: Quantitative Imaging in Medicine and Surgery
#11
JOURNAL ARTICLE
Kerstin Piayda, Stefan Bertog, Kolja Sievert, Horst Sievert
No abstract text is available yet for this article.
July 17, 2023: Science Bulletin
#12
JOURNAL ARTICLE
Atul Pathak, Ulrike M Rudolph, Manish Saxena, Thomas Zeller, Jochen Müller-Ehmsen, Erik Lipsic, Roland E Schmieder, Horst Sievert, Marcel Halbach, Faisal Sharif, Helen Parise, Tim A Fischell, Michael A Weber, David E Kandzari, Felix Mahfoud
BACKGROUND: Ultrasound and radiofrequency renal denervation (RDN) have been shown to safely lower blood pressure (BP) in hypertension. AIMS: The TARGET BP OFF-MED trial investigated the efficacy and safety of alcohol-mediated renal denervation (RDN) in the absence of antihypertensive medications. METHODS: This randomised, blinded, sham-controlled trial was conducted in 25 centres in Europe and the USA. Patients with a 24-hour systolic BP of 135-170 mmHg, an office systolic BP 140-180 mmHg and diastolic BP ≥90 mmHg on 0-2 antihypertensive medications were enrolled...
July 10, 2023: EuroIntervention
#13
JOURNAL ARTICLE
Lucas Lauder, Martin W Bergmann, Christina Paitazoglou, Ramazan Özdemir, Christos Iliadis, Jozef Bartunek, Alexander Lauten, Thomas Keller, Stephan Weber, Horst Sievert, Stefan D Anker, Felix Mahfoud
AIMS: We aim to assess the theoretical impact of the atrial flow regulator (AFR) on survival in heart failure. METHODS AND RESULTS: The prospective, multicentre, open-label, non-randomised PRELIEVE study (NCT03030274) assessed the safety and efficacy of the Occlutech AFR device in patients with symptomatic heart failure with reduced ejection fraction (HFrEF) (left ventricular ejection fraction (LVEF) ≥ 15% and <40%) or heart failure with preserved ejection fraction (HFpEF) (LVEF ≥40% and <70%) and elevated PCWP (≥15 mmHg at rest or ≥25 mmHg during exercise)...
June 13, 2023: ESC Heart Failure
#14
JOURNAL ARTICLE
Vivian Vij, Ignacio Cruz-González, Roberto Galea, Kerstin Piayda, Dominik Nelles, Lara Vogt, Steffen Gloekler, Monika Fürholz, Bernhard Meier, Lorenz Räber, Gilles O'Hara, Dabit Arzamendi, Victor Agudelo, Lluis Asmarats, Xavier Freixa, Eduardo Flores-Umanzor, Ole De Backer, Lars Sondergaard, Luis Nombela-Franco, Angela McInerney, Pablo Salinas, Kasper Korsholm, Jens Erik Nielsen-Kudsk, Shazia Afzal, Tobias Zeus, Felix Operhalski, Boris Schmidt, Gilles Montalescot, Paul Guedeney, Xavier Iriart, Noelie Miton, Jacqueline Saw, Thomas Gilhofer, Laurent Fauchier, Egzon Veliqi, Felix Meincke, Nils Petri, Peter Nordbeck, Rocio Gonzalez-Ferreiro, Deepak L Bhatt, Alessandra Laricchia, Antonio Mangieri, Heyder Omran, Jan Wilko Schrickel, Josep Rodes-Cabau, Georg Nickenig, Horst Sievert, Alexander Sedaghat
BACKGROUND: Device-related thrombus (DRT) after left atrial appendage closure (LAAC) is associated with adverse outcomes, i.e. ischemic stroke or systemic embolism (SE). Data on predictors of stroke/SE in the context of DRT are limited. AIMS: This study aimed to identify predisposing factors for stroke/SE in DRT patients. In addition, the temporal connection of stroke/SE to DRT diagnosis was analyzed. METHODS: The EUROC-DRT registry included 176 patients, in whom DRT after LAAC were diagnosed...
June 9, 2023: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
#15
JOURNAL ARTICLE
Gregg W Stone, Horst Sievert, Renu Virmani, Lea Waisman Shaler, Boaz Manash, David Neustadter
BACKGROUND: Reshaping the dilated left ventricle using a surgically implanted papillary muscle sling has been shown to provide long-term improvement in cardiac function compared to annuloplasty alone in patients with systolic heart failure. A papillary muscle sling which can be implanted via a transcatheter approach has the potential to make this treatment more widely available to patients. METHODS: The Vsling transcatheter papillary muscle sling device was evaluated in a chronic animal model (sacrificed at 30 and 90 days), in a simulator, and in a human cadaver...
August 2022: Structural heart: the journal of the Heart Team
#16
JOURNAL ARTICLE
Kerstin Piayda, Kolja Sievert, Horst Sievert, Tamaz Shaburishvili, Irakli Gogorishvili, Martin Rothman, James L Januzzi, JoAnn Lindenfeld, Gregg W Stone
BACKGROUND: Endovascular baroreflex amplification with the MobiusHD, a self-expanding stent-like device that is implanted in the internal carotid artery, was designed to reduce the sympathetic overactivity that contributes to progressive heart failure with reduced ejection fraction. METHODS: Symptomatic patients (New York Heart Association class III) with heart failure with reduced ejection fraction (left ventricular ejection fraction [LVEF] ≤40%) despite guideline directed medical therapy and n-terminal pro-B type natriuretic peptide (NT-proBNP) levels ≥400 pg/mL in whom carotid ultrasound and computed tomographic angiography demonstrated absence of carotid plaque were enrolled...
October 2022: Structural heart: the journal of the Heart Team
#17
JOURNAL ARTICLE
Christian Fastner, Claus Müller, Johannes Brachmann, Thorsten Lewalter, Ibrahim Akin, Horst Sievert, Matthias Käunicke, Uwe Zeymer, Matthias Hochadel, Steffen Schneider, Jochen Senges, Damir Erkapic, Christian Weiß
BACKGROUND: Interventional left atrial appendage occlusion (LAAO) provides an alternative to oral anticoagulation (OAC) for prophylaxis of thromboembolic events (TEs) in nonvalvular atrial fibrillation patients, predominantly in those with high bleeding risk and contraindications for long-term OAC. Although spontaneous echo contrast (SEC) is a well-known risk factor for atrial thrombus formation, little is known about whether this means an increased risk of device-related thrombus (DRT) or TEs following LAAO...
June 1, 2023: Journal of Interventional Cardiac Electrophysiology: An International Journal of Arrhythmias and Pacing
#18
JOURNAL ARTICLE
Domenico D'Amario, David Meerkin, Attilio Restivo, Hüseyin Ince, Horst Sievert, Andrea Wiese, Ulrich Schaefer, Carlo Trani, Antoni Bayes-Genis, Francisco Leyva, Zachary I Whinnett, Carlo Di Mario, Michael Jonas, Habib Manhal, Ignacio J Amat-Santos, Maria Del Trigo, Tuvia Ben Gal, Binyamin Ben Avraham, Tal Hasin, Sebastian Feickert, Giuseppe D'Ancona, Omar Abdul-Jawad Altisent, Oran Koren, Oren Caspi, William T Abraham, Filippo Crea, Stefan D Anker, Ran Kornowski, Leor Perl
AIMS: In heart failure (HF), implantable hemodynamic monitoring devices have been shown to optimize therapy, anticipating clinical decompensation and preventing hospitalization. Direct left-sided hemodynamic sensors offer theoretical benefits beyond pulmonary artery pressure (PAP) monitoring systems. We evaluated the safety, usability, and performance of a novel left atrial pressure (LAP) monitoring system in HF patients. METHODS AND RESULTS: The VECTOR-HF study(NCT03775161) was a first-in-human, prospective, multicenter, single-arm, clinical trial enrolling 30 patients with HF...
April 24, 2023: European Journal of Heart Failure
#19
REVIEW
Nikolaos Spilias, Travis M Howard, Chris M Anthony, Balint Laczay, Edward G Soltesz, Randall C Starling, Horst Sievert, Jerry D Estep, Samir R Kapadia, Rishi Puri
Despite significant advances in pharmacological, electrophysiological and valve therapies for heart failure with reduced ejection fraction (HFrEF), the associated morbidity, mortality and healthcare costs remain high. With a constantly growing heart failure population, the existing treatment gap between current and advanced heart failure therapies (e.g., left ventricular [LV] assist devices, heart transplantation) reflects a large unmet need, calling for novel therapeutic approaches. Left ventricular remodelling and dilatation, with or without scar formation, is the hallmark of cardiomyopathy and is associated with poor prognosis...
April 24, 2023: EuroIntervention
#20
JOURNAL ARTICLE
Iris Q Grunwald, Klaus Mathias, Stefan Bertog, Kenneth V Snyder, Horst Sievert, Adnan Siddiqui, Piotr Musialek, Marius Hornung, Panagiotes Papanagiotou, Simone Comelli, Sanjay Pillai, Helen Routledge, Rafal T Nizankowski, Ian Ewart, Klaus Fassbender, Anna L Kühn, Carlos A Alvarez, Bagrat Alekyan, Dimitry Skrypnik, Maria Politi, Lukasz Tekieli, Thomas Haldis, Shailesh Gaikwad, John Graeme Houston, Helen Donald-Simspon, Paul Guyler, Ivo Petrov, Christine Roffe, Mark Abelson, David Hargroves, Sunithi Mani, Anna Podlasek, Adam Witkowski, Kolja Sievert, Krzysztof Pawlowski, Artur Dziadkiewicz, Nelson L Hopkins
INTRODUCTION: Today, endovascular treatment (EVT) is the therapy of choice for strokes due to acute large vessel occlusion, irrespective of prior thrombolysis. This necessitates fast, coordinated multi-specialty collaboration. Currently, in most countries, the number of physicians and centres with expertise in EVT is limited. Thus, only a small proportion of eligible patients receive this potentially life-saving therapy, often after significant delays. Hence, there is an unmet need to train a sufficient number of physicians and centres in acute stroke intervention in order to allow widespread and timely access to EVT...
March 2023: Postępy W Kardiologii Interwencyjnej, Advances in Interventional Cardiology
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