Ehtesham Jameel, Hari Madhav, Prakhar Agrawal, Md Kausar Raza, Saiema Ahmedi, Abdur Rahman, Nida Shahid, Kashfa Shaheen, Chhaya Haresh Gajra, Ashma Khan, Md Zubbair Malik, Md Ali Imam, Md Kalamuddin, Jitendra Kumar, Dinesh Gupta, Shahid M Nayeem, Nikhat Manzoor, Asif Mohammad, Pawan Malhotra, Nasimul Hoda
Malaria still threatens half the globe population despite successful Artemisinin-based combination therapy. One of the reasons for our inability to eradicate malaria is the emergence of resistance to current antimalarials. Thus, there is a need to develop new antimalarials targeting Plasmodium proteins. The present study reported the design and synthesis of 4, 6 and 7-substituted quinoline-3-carboxylates 9(a - o) and carboxylic acids 10(a - b) for the inhibition of Plasmodium N-Myristoyltransferases (NMTs) using computational biology tools followed by chemical synthesis and functional analysis...
March 27, 2023: Journal of Biomolecular Structure & Dynamics