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https://www.readbyqxmd.com/read/28534690/decreased-left-atrial-myocardial-strain-in-patients-with-suboptimal-blood-pressure-control
#1
Xiao-Jing Chen, Chen Chen, Yu-Jia Liang, Xi-Lian Gao, Jing Jiang, Yu Kang, Yu-Cheng Chen, Qing Zhang, Zhi Zeng
BACKGROUND: Suboptimal blood pressure (BP) control is commonly observed in patients receiving antihypertensive agents, but the relationship between uncontrolled BP and left atrial (LA) impairment remains unknown. METHODS: This study enrolled 279 hypertensive patients who had been medicated, as well as 85 matched normal controls. The BP of systolic <140 mmHg and diastolic<90 mmHg was defined as optimal (HT1 group, n=146), otherwise as suboptimal BP control (HT2 group, n = 133)...
May 23, 2017: Clinical and Experimental Hypertension: CHE
https://www.readbyqxmd.com/read/28528579/phosphodiesterase-type-5-inhibition-may-reduce-diastolic-function-in-women-with-ischemia-but-no-obstructive-coronary-artery-disease
#2
Michael D Nelson, Puja K Mehta, Janet Wei, Behzad Sharif, Louise E J Thomson, Daniel Berman, Debiao Li, C Noel Bairey Merz
BACKGROUND: Ischemia, in the absence of obstructive coronary artery disease, is prevalent in women, and associated with increased risk for major cardiovascular events. Coronary microvascular dysfunction is prevalent in these patients, and associated with impaired diastolic function. Despite our general understanding, however, optimal treatment of this cohort remains elusive. METHODS: To address this knowledge gap, we performed an open-label treatment trial to assess whether phosphodiesterase type 5 inhibition improves coronary microvascular perfusion and diastolic function in women with signs and symptoms of ischemia but no evidence of obstructive coronary artery disease...
May 22, 2017: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/28528164/mri-derived-myocardial-strain-measures-in-normal-subjects
#3
Ha Q Vo, Thomas H Marwick, Kazuaki Negishi
OBJECTIVES: The aim of this study was to perform a systematic review and meta-analysis to estimate the normal ranges of magnetic resonance imaging (MRI)-based feature tracking (FT) and to identify sources of variations. Similar analyses were also performed for strain encoding, displacement encoding with stimulated echoes, and myocardial tagging. BACKGROUND: MRI-FT is a novel technique for quantification of myocardial deformation using MRI cine images. However, the reported 95% confidence intervals (CIs) from the 2 largest studies have no overlaps...
May 11, 2017: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/28528162/intervendor-differences-in-the-accuracy%C3%A2-of%C3%A2-detecting-regional-functional%C3%A2-abnormalities-a-report-from-the-eacvi-ase-strain-standardization-task%C3%A2-force
#4
Oana Mirea, Efstathios D Pagourelias, Jurgen Duchenne, Jan Bogaert, James D Thomas, Luigi P Badano, Jens-Uwe Voigt
OBJECTIVES: The purpose of this study was to compare the accuracy of vendor-specific and independent strain analysis tools to detect regional myocardial function abnormality in a clinical setting. BACKGROUND: Speckle tracking echocardiography has been considered a promising tool for the quantitative assessment of regional myocardial function. However, the potential differences among speckle tracking software with regard to their accuracy in identifying regional abnormality has not been studied extensively...
May 11, 2017: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/28527889/enhanced-cardiomyogenic-induction-of-mouse-pluripotent-cells-by-cyclic-mechanical-stretch
#5
Akankshya Shradhanjali, Brandon D Riehl, Jeong Soon Lee, Ligyeom Ha, Jung Yul Lim
The cardiac milieu is mechanically active with spontaneous contraction beginning from early development and persistent through maturation and homeostasis, suggesting that mechanical loading may provide biomimetic myocardial developmental signal. In this study, we tested the role of cyclic mechanical stretch loading in the cardiomyogenesis of pluripotent murine embryonic (P19) stem cells. A Flexcell tension system was utilized to apply equiaxial stretch (12% strain, 1.25 Hz frequency) to P19 cell-derived embryoid bodies (EBs)...
May 17, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28522755/increased-left-ventricular-extracellular-volume-and-enhanced-twist-function-in-type-1-diabetic-individuals
#6
Zainisha Vasanji, Ronald J Sigal, Neil Derek Eves, Debra L Isaac, Matthias G Friedrich, Kelvin Chow, Richard B Thompson
Individuals with type 1 diabetes (T1D) characteristically have high glycemic levels that over time can result in reactive fibrosis and abnormalities in myocardial function. T1 mapping with magnetic resonance imaging (MRI) can estimate the extent of reactive fibrosis by measurement of the extracellular volume fraction (ECV). The extent of alterations in the ECV and associated changes in left ventricular (LV) function and morphology in individuals with T1D is unknown. Fourteen individuals with long-term T1D and fourteen sex-, age-, and body mass index-matched controls without diabetes underwent MRI measurement of myocardial T1 and ECV values as well as LV function and morphology...
May 18, 2017: Journal of Applied Physiology
https://www.readbyqxmd.com/read/28515855/speckle-tracking-echocardiography-to-assess-regional-ventricular-function-in-patients-with-apical-hypertrophic-cardiomyopathy
#7
María Cristina Saccheri, Tomás Francisco Cianciulli, Luis Alberto Morita, Ricardo José Méndez, Martín Alejandro Beck, Juan Enrique Guerra, Alberto Cozzarin, Luciana Jimena Puente, Lorena Romina Balletti, Jorge Alberto Lax
AIM: To explore regional systolic strain of midwall and endocardial segments using speckle tracking echocardiography in patients with apical hypertrophic cardiomyopathy (HCM). METHODS: We prospectively assessed 20 patients (mean age 53 ± 16 years, range: 18-81 years, 10 were male), with apical HCM. We measured global longitudinal peak systolic strain (GLPSS) in the midwall and endocardium of the left ventricle. RESULTS: The diastolic thickness of the 4 apical segments was 16...
April 26, 2017: World Journal of Cardiology
https://www.readbyqxmd.com/read/28514784/effects-of-intensive-statin-therapy-on-left-ventricular-function-in-patients-with-myocardial-infarction-and-abnormal-glucose-tolerance
#8
Søren Auscher, Brian Bridal Løgstrup, Jacob Eifer Møller, Kristina Hoeg Vinther, Jess Lambrechtsen, Kenneth Egstrup
OBJECTIVES: Abnormal glucose tolerance in patients with acute myocardial infarction (AMI) is associated with greater mortality and adverse cardiovascular effects. As statins possess a range of beneficial pleiotropic effects on the cardiovascular system, we sought to assess the cardioprotective effects of statins on left ventricular function in patients with AMI in relation to glycometabolic state. METHODS: In a prospective, randomized trial, 140 patients with AMI were randomized to intensive statin therapy receiving statin loading with 80 mg of rosuvastatin followed by 40 mg daily or standard statin therapy...
May 18, 2017: Cardiology
https://www.readbyqxmd.com/read/28513231/left-atrial-mechanical-function-and-stiffness-in-patients-with-nondipper-hypertension-a-speckle-tracking-study
#9
Mehmet Demir, İbrahim Aktaş, Ahmet Yıldırım
BACKGROUND: Nondipper hypertension is associated with increased cardiovascular morbidity and mortality. Speckle tracking echocardiography is a novel and promising tool for detecting early changes in left atrial (LA) myocardial dysfunction. Our aim was to evaluate the LA mechanical function and stiffness in nondipper hypertensive patients by two-dimensional speckle tracking echocardiography strain parameters. METHOD: This study included 80 hypertensive patients. Hypertensive patients were divided into two groups: 50 dipper patients (29 male, mean age 51...
May 17, 2017: Clinical and Experimental Hypertension: CHE
https://www.readbyqxmd.com/read/28511954/high-intensity-interval-training-hiit-improves-resting-blood-pressure-metabolic-met-capacity-and-heart-rate-reserve-without-compromising-resting-myocardial-function-in-sedentary-aging-men
#10
Fergal M Grace, Peter Herbert, Adrian D Elliott, Jo Richards, Alexander Beaumont, Nicholas F Sculthorpe
BACKGROUND: This study examined the combination of pre-conditioning exercise with subsequent high intensity interval training (HIIT) on blood pressure, echocardiography, cardiac strain mechanics and maximal metabolic (MET) capacity in sedentary (SED) aging men compared with age matched masters athletes (LEX). METHODS: Using a STROBE compliant observational design, 39 aging male participants (SED; n=22, aged 62.7±5.2yrs) (LEX; n=17, aged=61.1±5.4yrs) were recruited to a study that necessitated three distinct assessment phases; enrolment (Phase A), following pre-conditioning exercise in SED (Phase B), then following 6weeks of HIIT performed once every five days by both groups before reassessment (Phase C)...
May 13, 2017: Experimental Gerontology
https://www.readbyqxmd.com/read/28511861/speckle-tracking-layer-specific-analysis-of-myocardial-deformation-and-evaluation-of-scar-transmurality-in-chronic-ischemic-heart-disease
#11
Michela Tarascio, Laura Anna Leo, Catherine Klersy, Romina Murzilli, Tiziano Moccetti, Francesco Fulvio Faletra
BACKGROUND: Identification of the extent of scar transmurality in chronic ischemic heart disease is important because it correlates with viability. The aim of this retrospective study was to evaluate whether layer-specific two-dimensional speckle-tracking echocardiography allows distinction of scar presence and transmurality. METHODS: A total of 70 subjects, 49 with chronic ischemic cardiomyopathy and 21 healthy subjects, underwent two-dimensional speckle-tracking echocardiography and late gadolinium-enhanced cardiac magnetic resonance...
May 13, 2017: Journal of the American Society of Echocardiography
https://www.readbyqxmd.com/read/28511859/reference-ranges-and-regional-patterns-of-left-ventricular-strain-and-strain-rate-using-two-dimensional-speckle-tracking-echocardiography-in-a-healthy-middle-aged-black-and-white-population-the-cardia-study
#12
Henrique T Moreira, Chike C Nwabuo, Anderson C Armstrong, Satoru Kishi, Ola Gjesdal, Jared P Reis, Pamela J Schreiner, Kiang Liu, Cora E Lewis, Stephen Sidney, Samuel S Gidding, João A C Lima, Bharath Ambale-Venkatesh
BACKGROUND: Strain and strain rate are sensitive markers of left ventricular (LV) myocardial function. The aim of this study was to assess reference ranges and regional patterns of LV strain and strain rate using two-dimensional speckle-tracking echocardiography in a large population of black and white subjects. METHODS: This study involved a retrospective review of prospectively collected images in 557 participants in the Coronary Artery Risk Development in Young Adults study who remained healthy at the year 25 examination...
May 13, 2017: Journal of the American Society of Echocardiography
https://www.readbyqxmd.com/read/28511858/reduced-myocardial-reserve-in-young-x-linked-muscular-dystrophy-mice-diagnosed-by-two-dimensional-strain-analysis-combined-with%C3%A2-stress-echocardiography
#13
Zhenzhou Li, Ying Li, Li Zhang, Xiaoying Zhang, Rebecca Sullivan, Xiaojie Ai, Christopher Szeto, Angela Cai, Longjian Liu, Weidong Xiao, Quanshui Li, Shuping Ge, Xiongwen Chen
BACKGROUND: Early, sensitive, and reproducible evaluation of left ventricular function is imperative for the diagnosis of cardiac dysfunction in patients with Duchene muscular dystrophy. The aim of this study was to test the hypothesis that combining two-dimensional strain analysis with catecholamine stress could be a sensitive method for detecting early cardiac dysfunction. METHODS: Mdx (C57BL/10ScSn-Dmdmdx/J, a mouse model of DMD) and control (C57BL/10ScSn) mice were studied with conventional M-mode and high-frequency ultrasound-based two-dimensional speckle-tracking echocardiography using long- and short-axis images of the left ventricle at baseline and after intraperitoneal isoprenaline (ISO) administration (2 μg/g body weight)...
May 13, 2017: Journal of the American Society of Echocardiography
https://www.readbyqxmd.com/read/28511156/the-role-of-the-persistent-enterovirus-infection-in-development-of-acute-stroke
#14
Natalia G Andriushkova, Nataliia S Turchyna, Vadym A Poniatowski, Ludmyla V Dolinchuk, Valentyna V Melnyk, Volodymyr P Shyrobokov, Nataliia V Zakharchenko
INTRODUCTION: The role of enteroviruses in development of dilated cardiomyopathy, myocardial infarction, myocarditis, pericarditis is known. THE AIM: To examine the role of chronic enterovirus infections in development of acute stroke. MATERIAL AND METHODS: Blood samples from 72 patients with acute stroke (study group) and 35 patients without vascular disease (control group) were investigated by reverse transcription polymerase chain reaction for the presence of enterovirus RNA, by using virological method to detect enteroviruses, by ELISA for the levels of IgM and IgG antibodies to enteroviruses...
2017: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/28507980/hypertension-in-the-pediatric-kidney-transplant-recipient
#15
REVIEW
Olga Charnaya, Asha Moudgil
Hypertension after kidney transplant is a frequent occurrence in pediatric patients. It is a risk factor for graft loss and contributes to the significant burden of cardiovascular disease (CVD) in this population. The etiology of posttransplant hypertension is multifactorial including donor factors, recipient factors, medications, and lifestyle factors similar to those prevalent in the general population. Ambulatory blood pressure monitoring has emerged as the most reliable method for measuring hypertension in pediatric transplant recipients, and many consider it to be essential in the care of these patients...
2017: Frontiers in Pediatrics
https://www.readbyqxmd.com/read/28505345/cardio-oncology-a-multidisciplinary-approach-for-detection-prevention-and-management-of-cardiac-dysfunction-in-cancer-patients
#16
Kazuko Tajiri, Kazutaka Aonuma, Ikuo Sekine
Cardiac dysfunction that develops during or after completion of cancer therapy is a growing health concern that should be addressed in a multidisciplinary setting. Cardio-oncology is a new discipline that focuses on screening, monitoring and treating cardiovascular disease during and after cancer treatment. A baseline cardiovascular risk assessment is essential. For high-risk patients, a tailored and detailed plan for cardiovascular management throughout treatment and beyond should also be established. Anthracycline and/or trastuzumab-containing chemotherapy and chest-directed radiation therapy are well known cardiotoxic cancer therapies...
May 15, 2017: Japanese Journal of Clinical Oncology
https://www.readbyqxmd.com/read/28500369/feature-tracking-myocardial-strain-analysis-in-acute-myocarditis-diagnostic-value-and-association-with-myocardial-oedema
#17
Julian A Luetkens, Ulrike Schlesinger-Irsch, Daniel L Kuetting, Darius Dabir, Rami Homsi, Jonas Doerner, Frederic C Schmeel, Rolf Fimmers, Alois M Sprinkart, Claas P Naehle, Hans H Schild, Daniel Thomas
OBJECTIVES: To investigate the diagnostic value of cardiac magnetic resonance (CMR) feature-tracking (FT) myocardial strain analysis in patients with suspected acute myocarditis and its association with myocardial oedema. METHODS: Forty-eight patients with suspected acute myocarditis and 35 control subjects underwent CMR. FT CMR analysis of systolic longitudinal (LS), circumferential (CS) and radial strain (RS) was performed. Additionally, the protocol allowed for the assessment of T1 and T2 relaxation times...
May 12, 2017: European Radiology
https://www.readbyqxmd.com/read/28497844/echocardiographic-evaluation-of-right-ventricular-systolic-function-the-traditional-and-innovative-approach
#18
Dorota Smolarek, Marcin Gruchała, Wojciech Sobiczewski
Estimation of right ventricular (RV) performance still remains technically challenging due to its anatomical and functional distinctiveness. The current guidelines for the echocardiographic quantification of RV function recommend using multiple indices to describe the RV in a thorough and comprehensive manner, such as RV index of myocardial performance, tricuspid annular plane systolic excursion, fractional area change, Doppler tissue imaging-derived tricuspid lateral annular systolic velocity (S'-wave), three-dimensional RV ejection fraction (3D RVEF), longitudinal strain (RVLS)/strain rate by speckle-tracking echocardiography (STE)...
May 12, 2017: Cardiology Journal
https://www.readbyqxmd.com/read/28497431/effect-of-catheter-based-renal-denervation-on-left-ventricular-function-mass-and-un-twist-with-two-dimensional-speckle-tracking-echocardiography
#19
Lida Feyz, Bas M van Dalen, Marcel L Geleijnse, Nicolas M Van Mieghem, Ron T van Domburg, Joost Daemen
BACKGROUND: Speckle tracking echocardiography (STE) is an echocardiography modality that is able to measure left ventricular (LV) characteristics, including rotation, strain and strain rate. Strain measures myocardial fibre contraction and relaxation. This study aims to assess the effect of renal sympathetic denervation (RDN) on functional myocardial parameters, including STE, and to identify potential differences between responders and non-responders. METHODS: The study population consisted of 31 consecutive patients undergoing RDN in the context of treatment for resistant hypertension...
May 11, 2017: Journal of Echocardiography
https://www.readbyqxmd.com/read/28490697/-effect-of-left-ventricular-hypertrophy-and-deformation-on-cardiac-function-in-patients-with-uremia-cardiomyopathy-by-using-quantitative-speckle-tracking-technology
#20
Yi Zheng, Xiaohong Yang, Qiping Zhou, Yaoyao Huang, Fan Zhang, Liangyu Wang
To evaluate the effect of left ventricular hypertrophy and deformation on cardiac function in patients with uremic cardiomyopathy (UCM) by using the technology of two dimensional speckle tracking imaging (2D-STI).
 Methods: A total of 67 UCM patients were randomly divided into the normal cardiac function group (subgroup A, 32 cases) and the abnormal cardiac function group (subgroup B, 35 cases) according to the New York Heart Association points (NYHA-P). A total of 30 healthy subjetcs served as the control group...
April 28, 2017: Zhong Nan da Xue Xue Bao. Yi Xue Ban, Journal of Central South University. Medical Sciences
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