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https://www.readbyqxmd.com/read/28636768/driving-aggression-and-anxiety-intersections-assessment-and-interventions
#1
Heidi M Zinzow, Stephanie M Jeffirs
OBJECTIVE: Driving aggression and anxiety are significant contributors to risky driving and motor vehicle crashes (MVCs), which are leading causes of U.S. morbidity and mortality. Even though aggression and anxiety can be conceptualized as related features of the fight-or-flight response, literature on these topics has not been integrated. Driving aggression and anxiety are also transdiagnostic constructs that span multiple psychiatric disorders. Assessment and treatment of these complex problems must be understood to reduce the public health burden of MVCs...
June 21, 2017: Journal of Clinical Psychology
https://www.readbyqxmd.com/read/28632202/genome-wide-association-study-of-borderline-personality-disorder-reveals-genetic-overlap-with-bipolar-disorder-major-depression-and-schizophrenia
#2
S H Witt, F Streit, M Jungkunz, J Frank, S Awasthi, C S Reinbold, J Treutlein, F Degenhardt, A J Forstner, S Heilmann-Heimbach, L Dietl, C E Schwarze, D Schendel, J Strohmaier, A Abdellaoui, R Adolfsson, T M Air, H Akil, M Alda, N Alliey-Rodriguez, O A Andreassen, G Babadjanova, N J Bass, M Bauer, B T Baune, F Bellivier, S Bergen, A Bethell, J M Biernacka, D H R Blackwood, M P Boks, D I Boomsma, A D Børglum, M Borrmann-Hassenbach, P Brennan, M Budde, H N Buttenschøn, E M Byrne, P Cervantes, T-K Clarke, N Craddock, C Cruceanu, D Curtis, P M Czerski, U Dannlowski, T Davis, E J C de Geus, A Di Florio, S Djurovic, E Domenici, H J Edenberg, B Etain, S B Fischer, L Forty, C Fraser, M A Frye, J M Fullerton, K Gade, E S Gershon, I Giegling, S D Gordon, K Gordon-Smith, H J Grabe, E K Green, T A Greenwood, M Grigoroiu-Serbanescu, J Guzman-Parra, L S Hall, M Hamshere, J Hauser, M Hautzinger, U Heilbronner, S Herms, S Hitturlingappa, P Hoffmann, P Holmans, J-J Hottenga, S Jamain, I Jones, L A Jones, A Juréus, R S Kahn, J Kammerer-Ciernioch, G Kirov, S Kittel-Schneider, S Kloiber, S V Knott, M Kogevinas, M Landén, M Leber, M Leboyer, Q S Li, J Lissowska, S Lucae, N G Martin, F Mayoral-Cleries, S L McElroy, A M McIntosh, J D McKay, A McQuillin, S E Medland, C M Middeldorp, Y Milaneschi, P B Mitchell, G W Montgomery, G Morken, O Mors, T W Mühleisen, B Müller-Myhsok, R M Myers, C M Nievergelt, J I Nurnberger, M C O'Donovan, L M O Loohuis, R Ophoff, L Oruc, M J Owen, S A Paciga, B W J H Penninx, A Perry, A Pfennig, J B Potash, M Preisig, A Reif, F Rivas, G A Rouleau, P R Schofield, T G Schulze, M Schwarz, L Scott, G C B Sinnamon, E A Stahl, J Strauss, G Turecki, S Van der Auwera, H Vedder, J B Vincent, G Willemsen, C C Witt, N R Wray, H S Xi, A Tadic, N Dahmen, B H Schott, S Cichon, M M Nöthen, S Ripke, A Mobascher, D Rujescu, K Lieb, S Roepke, C Schmahl, M Bohus, M Rietschel
Borderline personality disorder (BOR) is determined by environmental and genetic factors, and characterized by affective instability and impulsivity, diagnostic symptoms also observed in manic phases of bipolar disorder (BIP). Up to 20% of BIP patients show comorbidity with BOR. This report describes the first case-control genome-wide association study (GWAS) of BOR, performed in one of the largest BOR patient samples worldwide. The focus of our analysis was (i) to detect genes and gene sets involved in BOR and (ii) to investigate the genetic overlap with BIP...
June 20, 2017: Translational Psychiatry
https://www.readbyqxmd.com/read/28629272/treating-suicidal-thoughts-and-behaviors-within-an-emotional-disorders-framework-acceptability-and-feasibility-of-the-unified-protocol-in-an-inpatient-setting
#3
Kate H Bentley, Shannon Sauer-Zavala, Clair F Cassiello-Robbins, Laren R Conklin, Stephanie Vento, Danyele Homer
We provide a theoretical rationale for applying a transdiagnostic, shared mechanism treatment (the Unified Protocol for Transdiagnostic Treatment of Emotional Disorders [UP]) to suicidal thoughts and behaviors. We also present results from a proof of concept study examining the feasibility and acceptability of adding a modified UP to treatment as usual (TAU) in an inpatient setting for individuals reporting a recent suicide attempt or active suicidal ideation. Participants ( N = 12) were randomly assigned to receive UP + TAU or TAU alone...
July 2017: Behavior Modification
https://www.readbyqxmd.com/read/28625599/disparities-in-anxiety-and-its-disorders
#4
EDITORIAL
Michael J Zvolensky, Lorra Garey, Jafar Bakhshaie
Much of the scientific work addressing the enigmas of anxiety and its disorders has been conducted among European Americans. This work has led to great progress into the nature of anxiety psychopathology, including etiologic, maintenance, and relapse processes. Moreover, evidenced-based treatments for anxiety and its disorders have arguably been among the best in the field of psychopathology for well over two decades. Yet, the progress thus far attained on the nature and treatment of anxiety disorders has not benefited all members of society equally...
May 2017: Journal of Anxiety Disorders
https://www.readbyqxmd.com/read/28625186/how-predictable-are-symptoms-in-psychopathological-networks-a-reanalysis-of-18-published-datasets
#5
J M B Haslbeck, E I Fried
BACKGROUND: Network analyses on psychopathological data focus on the network structure and its derivatives such as node centrality. One conclusion one can draw from centrality measures is that the node with the highest centrality is likely to be the node that is determined most by its neighboring nodes. However, centrality is a relative measure: knowing that a node is highly central gives no information about the extent to which it is determined by its neighbors. Here we provide an absolute measure of determination (or controllability) of a node - its predictability...
June 19, 2017: Psychological Medicine
https://www.readbyqxmd.com/read/28623880/associations-between-anhedonia-and-marijuana-use-escalation-across-mid-adolescence
#6
Adam M Leventhal, Junhan Cho, Matthew D Stone, Jessica L Barrington-Trimis, Chih-Ping Chou, Steven Y Sussman, Nathaniel R Riggs, Jennifer B Unger, Janet Audrain-McGovern, David R Strong
BACKGROUND AND AIMS: Anhedonia-a transdiagnostic psychopathological trait indicative of inability to experience pleasure-could lead to and result from adolescent marijuana use, yet this notion has not been tested. This study aimed to estimate the association of: (1) anhedonia at age 14 with rate of change in marijuana use over an 18-month follow-up, and (2) marijuana use at age 14 with rate of change in anhedonia over follow-up. Secondary aims were to test whether gender, baseline marijuana use history, and peer marijuana use moderated these associations...
June 17, 2017: Addiction
https://www.readbyqxmd.com/read/28623184/scaling-up-psychological-treatments-a-countrywide-test-of-the-online-training-of-therapists
#7
Christopher G Fairburn, Elizabeth Allen, Suzanne Bailey-Straebler, Marianne E O'Connor, Zafra Cooper
BACKGROUND: A major barrier to the widespread dissemination of psychological treatments is the way that therapists are trained. The current method is not scalable. OBJECTIVE: Our objective was to conduct a proof-of-concept study of Web-centered training, a scalable online method for training therapists. METHODS: The Irish Health Service Executive identified mental health professionals across the country whom it wanted to be trained in a specific psychological treatment for eating disorders...
June 16, 2017: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/28617140/introduction-to-the-special-section-linking-the-mmpi-2-rf-to-contemporary-models-of-psychopathology
#8
Martin Sellbom, Paul A Arbisi
This special section considers 9 independent articles that seek to link the Minnesota Multiphasic Personality Inventory-2-Restructured Form (MMPI-2-RF; Ben-Porath & Tellegen, 2008/ 2011 ) to contemporary models of psychopathology. Sellbom ( this issue ) maps the Specific Problems scales onto hierarchical psychopathology structures, whereas Romero, Toorabally, Burchett, Tarescavage, and Glassmire ( this issue ) and Shkalim, Almagor, and Ben-Porath ( this issue ) show evidence of linking the instruments' scales to diagnostic representations of common higher order psychopathology constructs...
July 2017: Journal of Personality Assessment
https://www.readbyqxmd.com/read/28611219/inhibitory-engrams-in-perception-and-memory
#9
Helen C Barron, Tim P Vogels, Timothy E Behrens, Mani Ramaswami
Nervous systems use excitatory cell assemblies to encode and represent sensory percepts. Similarly, synaptically connected cell assemblies or "engrams" are thought to represent memories of past experience. Multiple lines of recent evidence indicate that brain systems create and use inhibitory replicas of excitatory representations for important cognitive functions. Such matched "inhibitory engrams" can form through homeostatic potentiation of inhibition onto postsynaptic cells that show increased levels of excitation...
June 13, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28603665/putative-brain-networks-underlying-repetitive-negative-thinking-and-comorbid-internalizing-problems-in-autism
#10
Catherine A Burrows, Kiara R Timpano, Lucina Q Uddin
Many high-functioning individuals with autism spectrum disorder (ASD) also experience depression and anxiety, yet little is known about mechanisms underlying this comorbidity. Repetitive negative thinking (RNT) about self-referential information is a transdiagnostic cognitive vulnerability factor that may account for the relationship between these two classes of symptoms. We propose a model where self-referential processing and cognitive inflexibility interact to increase risk for RNT, leading to internalizing problems in ASD...
May 2017: Clinical Psychological Science
https://www.readbyqxmd.com/read/28599832/model-based-control-in-dimensional-psychiatry
#11
REVIEW
Valerie Voon, Andrea Reiter, Miriam Sebold, Stephanie Groman
We use parallel interacting goal-directed and habitual strategies to make our daily decisions. The arbitration between these strategies is relevant to inflexible repetitive behaviors in psychiatric disorders. Goal-directed control, also known as model-based control, is based on an affective outcome relying on a learned internal model to prospectively make decisions. In contrast, habit control, also known as model-free control, is based on an integration of previous reinforced learning autonomous of the current outcome value and is implicit and more efficient but at the cost of greater inflexibility...
April 23, 2017: Biological Psychiatry
https://www.readbyqxmd.com/read/28597860/co-occurring-depression-and-alcohol-use-disorders-in-south-east-asia-a-narrative-review
#12
REVIEW
Yatan Pal Singh Balhara, Prashant Gupta, Deeksha Elwadhi
Depression and alcohol-use disorders frequently co-occur and the presence of one augments the adverse consequences of the other. This article reviews and synthesizes the available literature on depression and alcohol-use disorders from the World Health Organization (WHO) South-East Asia Region, with respect to epidemiology, screening instruments, interventions and services, and policy. In common with other low- and middle-income settings, data from this region on co-occurring depression and alcohol-use disorders are scarce...
April 2017: WHO South-East Asia Journal of Public Health
https://www.readbyqxmd.com/read/28579659/emotion-regulation-and-the-transdiagnostic-role-of-repetitive-negative-thinking-in-adolescents-with-social-anxiety-and-depression
#13
David H Klemanski, Joshua Curtiss, Katie A McLaughlin, Susan Nolen-Hoeksema
Social anxiety and depression are common mental health problems among adolescents and are frequently comorbid. Primary aims of this study were to (1) elucidate the nature of individual differences in specific emotion regulation deficits among adolescents with symptoms of social anxiety and depression, and (2) determine whether repetitive negative thinking (RNT) functions as a transdiagnostic factor. A diverse sample of adolescents (N = 1065) completed measures assessing emotion regulation and symptoms of social anxiety and depression...
April 2017: Cognitive Therapy and Research
https://www.readbyqxmd.com/read/28579400/emotion-regulation-in-mood-and-anxiety-disorders-a-meta-analysis-of-fmri-cognitive-reappraisal-studies
#14
REVIEW
Maria Picó-Pérez, Joaquim Radua, Trevor Steward, José M Menchón, Carles Soriano-Mas
Emotion regulation by means of cognitive reappraisal has been widely studied with functional magnetic resonance imaging (fMRI). To date, several meta-analyses of studies using cognitive reappraisal tasks in healthy volunteers have been carried out, but no meta-analyses have yet been performed on the fMRI data of clinical populations with identified alterations in emotion regulation capacity. We provide a comprehensive meta-analysis of cognitive reappraisal fMRI studies in populations of patients with mood or anxiety disorders, yielding a pooled sample of 247 patients and 262 controls from thirteen independent studies...
June 1, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/28577580/the-role-of-threat-level-and-intolerance-of-uncertainty-iu-in-anxiety-an-experimental-test-of-iu-theory
#15
Mary E Oglesby, Norman B Schmidt
Intolerance of uncertainty (IU) has been proposed as an important transdiagnostic variable within mood- and anxiety-related disorders. The extant literature has suggested that individuals high in IU interpret uncertainty more negatively. Furthermore, theoretical models of IU posit that those elevated in IU may experience an uncertain threat as more anxiety provoking than a certain threat. However, no research to date has experimentally manipulated the certainty of an impending threat while utilizing an in vivo stressor...
July 2017: Behavior Therapy
https://www.readbyqxmd.com/read/28577505/transdiagnostic-treatment-of-bipolar-disorder-and-comorbid-anxiety-using-the-unified-protocol-for-emotional-disorders-a-pilot-feasibility-and-acceptability-trial
#16
Kristen K Ellard, Emily E Bernstein, Casey Hearing, Ji Hyun Baek, Louisa G Sylvia, Andrew A Nierenberg, David H Barlow, Thilo Deckersbach
BACKGROUND: Comorbid anxiety in bipolar disorder (BD) is associated with greater illness severity, reduced treatment response, and greater impairment. Treating anxiety in the context of BD is crucial for improving illness course and outcomes. The current study examined the feasibility, acceptability and preliminary efficacy of the Unified Protocol (UP), a transdiagnostic cognitive behavioral therapy, as an adjunctive treatment to pharmacotherapy for BD and comorbid anxiety disorders. METHODS: Twenty-nine patients with BD and at least one comorbid anxiety disorder were randomized to pharmacotherapy treatment-as-usual (TAU) or TAU with 18 sessions of the UP (UP+TAU)...
September 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28575646/improvement-in-quality-of-life-and-sexual-functioning-in-a-comorbid-sample-after-the-unified-protocol-transdiagnostic-group-treatment
#17
Ana Claudia Corrêa de Ornelas Maia, Jenny Sanford, Hannah Boettcher, Antonio E Nardi, David Barlow
Patients with multiple mental disorders often experience sexual dysfunction and reduced quality of life. The unified protocol (UP) is a transdiagnostic treatment for emotional disorders that has the potential to improve quality of life and sexual functioning via improved emotion management. The present study evaluates changes in quality of life and sexual functioning in a highly comorbid sample treated with the UP in a group format. Forty-eight patients were randomly assigned to either a UP active-treatment group or a medication-only control group...
October 2017: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/28575049/cognitive-and-affective-trait-and-state-factors-influencing-the-long-term-symptom-course-in-remitted-depressed-patients
#18
Christina Timm, Bettina Ubl, Vera Zamoscik, Ulrich Ebner-Priemer, Iris Reinhard, Silke Huffziger, Peter Kirsch, Christine Kuehner
BACKGROUND: Major depressive disorder (MDD) is characterized by a high risk for relapses and chronic developments. Clinical characteristics such as residual symptoms have been shown to negatively affect the long-term course of MDD. However, it is unclear so far how trait repetitive negative thinking (RNT) as well as cognitive and affective momentary states, the latter experienced during daily-life, affect the long-term course of MDD. METHOD: We followed up 57 remitted depressed (rMDD) individuals six (T2) and 36 (T3) months after baseline...
2017: PloS One
https://www.readbyqxmd.com/read/28566945/inflammation-opportunities-for-treatment-stratification-among-individuals-diagnosed-with-mood-disorders
#19
Mehala Subramaniapillai, Nicole E Carmona, Carola Rong, Roger S McIntyre
Mood disorders continue to be a significant burden to those affected, resulting in significant illness-associated disability and premature mortality. In addition to mood disturbance, individuals also suffer from other transdiagnostic impairments (eg, anhedonia and cognitive impairment). Although there have been significant advancements in psychiatric treatment over the last few decades, treatment efficacy (eg, symptom remission, lack of functional recovery, and disease modification) continues to be an important limitation...
March 2017: Dialogues in Clinical Neuroscience
https://www.readbyqxmd.com/read/28557508/neural-markers-of-emotional-face-perception-across-psychotic-disorders-and-general-population
#20
Amri Sabharwal, Roman Kotov, Akos Szekely, Hoi-Chung Leung, Deanna M Barch, Aprajita Mohanty
There is considerable variation in negative and positive symptoms of psychosis, global functioning, and emotional face perception (EFP), not only in schizophrenia but also in other psychotic disorders and healthy individuals. However, EFP impairment and its association with worse symptoms and global functioning have been examined largely in the domain of schizophrenia. The present study adopted a dimensional approach to examine the association of behavioral and neural measures of EFP with symptoms of psychosis and global functioning across individuals with schizophrenia spectrum (SZ; N = 28) and other psychotic (OP; N = 29) disorders, and never-psychotic participants (NP; N = 21)...
May 29, 2017: Journal of Abnormal Psychology
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