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Calprotectin

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https://www.readbyqxmd.com/read/29781175/translational-safety-biomarkers-of-colonic-barrier-integrity-in-the-rat
#1
Tim Erkens, Ruud Bueters, Marjolein van Heerden, Filip Cuyckens, Rob Vreeken, Nick Goeminne, Lieve Lammens
The intestinal barrier controls intestinal permeability, and its disruption has been associated with multiple diseases. Therefore, preclinical safety biomarkers monitoring barrier integrity are essential during the development of drugs targeting the intestines, particularly if starting treatment early after onset of disease. Classical toxicology endpoints are not sensitive enough and therefore our objective was to identify non-invasive markers enabling early in vivo detection of colonic barrier perturbation...
May 20, 2018: Journal of Applied Toxicology: JAT
https://www.readbyqxmd.com/read/29760785/monitoring-crohn-s-disease-activity-endoscopy-fecal-markers-and-computed-tomography-enterography
#2
Susana Lopes, Patrícia Andrade, Joana Afonso, Rui Cunha, Eduardo Rodrigues Pinto, Isabel Ramos, Guilherme Macedo, Fernando Magro
Background: The treatment goal of Crohn's disease (CD) has moved towards achieving mucosal healing, resolution of transmural inflammation, and normalization of biomarkers. The purpose of this study was to evaluate how well computed tomography enterography (CTE) and fecal calprotectin (FC) correlated with endoscopic activity in newly diagnosed patients with CD and after 1 year of therapy. Methods: Consecutive patients with newly diagnosed CD were evaluated by endoscopy, CTE, and FC at diagnosis and 12 months after beginning immunosuppression...
2018: Therapeutic Advances in Gastroenterology
https://www.readbyqxmd.com/read/29756637/withdrawal-of-immunosuppressant-or-biologic-therapy-for-patients-with-quiescent-crohn-s-disease
#3
REVIEW
Ray K Boyapati, Joana Torres, Carolina Palmela, Claire E Parker, Orli M Silverberg, Sonam D Upadhyaya, Tran M Nguyen, Jean-Frédéric Colombel
BACKGROUND: Crohn's disease (CD) is a chronic, relapsing and remitting disease of the gastrointestinal tract that can cause significant morbidity and disability. Current treatment guidelines recommend early intervention with immunosuppressant or biological therapy in high-risk patients with a severe disease phenotype at presentation. The feasibility of therapeutic de-escalation once remission is achieved is a commonly encountered question in clinical practice, driven by patient and clinician concerns regarding safety, adverse events, cost and national regulations...
May 12, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29753375/positive-correlation-of-fecal-calprotectin-with-serum-antioxidant-enzymes-in-patients-with-inflammatory-bowel-disease-accidental-numerical-correlation-or-a-new-finding
#4
Mostafa Vaghari-Tabari, Soheila Moein, Durdi Qujeq, Mehrdad Kashifard, Karimollah Hajian-Tilaki
BACKGROUND: Oxidative stress occuring in patients diagnosed with inflammatory bowel disease (IBD), but the relationship between oxidative stress, disease activity and inflammatory markers has not been well established. MATERIALS AND METHODS: A total of 30 patients diagnosed with IBD and 30 volunteers who had normal colonoscopies, selected as controls, were used for this study. The serum levels of antioxidant enzymes (catalase and glutathione peroxidase) and oxidative markers (malondialdehyde [MDA] and total antioxidant capacity) were compared between the 2 groups...
May 2018: American Journal of the Medical Sciences
https://www.readbyqxmd.com/read/29740189/reference-intervals-for-stool-calprotectin-in-preterm-neonates-and-their-utility-for-the-diagnosis-of-necrotizing-enterocolitis
#5
B C MacQueen, R D Christensen, C C Yost, P V Gordon, V L Baer, R Schlaberg, J Lowe
OBJECTIVE: Calprotectin is an antimicrobial protein found in stool when released by granulocytes. We sought to create stool calprotectin reference ranges in preterm neonates and to evaluate whether levels exceeding the upper reference interval are diagnostic for necrotizing enterocolitis (NEC). STUDY DESIGN: Stool calprotectin was measured in premature neonates without gastrointestinal pathology to create reference intervals. For comparison, levels from infants undergoing "rule out NEC" evaluations were plotted on these reference intervals...
May 8, 2018: Journal of Perinatology: Official Journal of the California Perinatal Association
https://www.readbyqxmd.com/read/29729144/improving-ibd-diagnosis-and-monitoring-by-understanding-preanalytical-analytical-and-biological-fecal-calprotectin-variability
#6
Andrea Padoan, Renata D'Incà, Maria Luisa Scapellato, Rudi De Bastiani, Roberta Caccaro, Claudia Mescoli, Stefania Moz, Dania Bozzato, Carlo-Federico Zambon, Greta Lorenzon, Massimo Rugge, Mario Plebani, Daniela Basso
BACKGROUND: The appropriate clinical use of fecal calprotectin (fCal) might be compromised by incomplete harmonization between assays and within- and between-subjects variability. Our aim was to investigate the analytical and biological variability of fCal in order to provide tools for interpreting fCal in the clinical setting. METHODS: Experiments were conducted to investigate the effects of temperature and storage time on fCal. Thirty-nine controls were enrolled to verify biological variability, and a case-control study was conducted on 134 controls and 110 IBD patients to compare the clinical effectiveness of three different fCal assays: ELISA, CLIA and turbidimetry...
May 5, 2018: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/29727465/biphasic-zinc-compartmentalisation-in-a-human-fungal-pathogen
#7
Aaron C Crawford, Laura E Lehtovirta-Morley, Omran Alamir, Maria J Niemiec, Bader Alawfi, Mohammad Alsarraf, Volha Skrahina, Anna C B P Costa, Andrew Anderson, Sujan Yellagunda, Elizabeth R Ballou, Bernhard Hube, Constantin F Urban, Duncan Wilson
Nutritional immunity describes the host-driven manipulation of essential micronutrients, including iron, zinc and manganese. To withstand nutritional immunity and proliferate within their hosts, pathogenic microbes must express efficient micronutrient uptake and homeostatic systems. Here we have elucidated the pathway of cellular zinc assimilation in the major human fungal pathogen Candida albicans. Bioinformatics analysis identified nine putative zinc transporters: four cytoplasmic-import Zip proteins (Zrt1, Zrt2, Zrt3 and orf19...
May 4, 2018: PLoS Pathogens
https://www.readbyqxmd.com/read/29726893/the-effect-of-vitamin-d-on-intestinal-inflammation-and-faecal-microbiota-in-patients-with-ulcerative-colitis
#8
Mayur Garg, Philip Hendy, John Nik Ding, Sophie Shaw, Georgina Hold, Ailsa Hart
Background and Aims: There is evidence vitamin D may be immunomodulatory and alter faecal microbiota, but results from clinical studies in humans to date have been inconclusive. This study aimed to assess the effect of vitamin D replacement in vitamin D deficient patients with and without ulcerative colitis (UC) on inflammation and faecal microbiota. Methods: Vitamin D was replaced over 8 weeks in patients with active UC (defined by faecal calprotectin ≥100 µg/g), inactive UC (faecal calprotectin <100 µg/g), and non-IBD controls with baseline 25(OH) vitamin D <50 nmol/L, and markers of inflammation and faecal microbiota analysed...
May 3, 2018: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/29722829/fecal-calprotectin-as-a-selection-tool-for-small-bowel-capsule-endoscopy-in-suspected-crohn-s-disease
#9
Sara Monteiro, Mara Barbosa, Tiago Cúrdia Gonçalves, Pedro Boal Carvalho, Maria João Moreira, Bruno Rosa, José Cotter
Background: Small bowel capsule endoscopy (SBCE) is a firstline examination in patients with suspected Crohn's disease (CD) after negative ileocolonoscopy. Fecal calprotectin (FC) is a noninvasive marker of intestinal inflammation. The aim of this study was to evaluate the predictive value of FC in inflammatory activity detected by SBCE in patients with suspected CD. Methods: This is a retrospective study including patients who underwent SBCE for suspected CD between March 2015 and October 2016...
May 2, 2018: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/29718414/a-simple-1-day-colon-capsule-endoscopy-procedure-demonstrated-to-be-a-highly-acceptable-monitoring-tool-for-ulcerative-colitis
#10
Shinji Okabayashi, Taku Kobayashi, Masaru Nakano, Takahiko Toyonaga, Ryo Ozaki, Maria Carla Tablante, Satoshi Kuronuma, Osamu Takeuchi, Toshifumi Hibi
Background: Second-generation colon capsule endoscopy (CCE-2) has been reported as a potential tool for monitoring ulcerative colitis (UC). However, its excretion rate is still unsatisfactory, and the bowel preparation regimen is not well tolerated. Furthermore, a standard bowel preparation regimen validated for UC has not been established. The aim of this study was to develop a simple 1-day CCE-2 procedure while evaluating its excretion rate and acceptability in UC. Factors associated with the colonic transit time and acceptability of CCE-2 were evaluated...
April 30, 2018: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/29718391/serologic-reactivity-reflects-clinical-expression-of-ulcerative-colitis-in-children
#11
Elizabeth A Spencer, Sonia M Davis, David R Mack, Brendan M Boyle, Anne M Griffiths, Neal S LeLeiko, Cary G Sauer, David J Keljo, James F Markowitz, Susan S Baker, Joel R Rosh, Robert N Baldassano, Maria Oliva-Hemker, Marian D Pfefferkorn, Anthony R Otley, Melvin B Heyman, Joshua D Noe, Ashish S Patel, Paul A Rufo, M Alison Marquis, Thomas D Walters, Margaret H Collins, Subra Kugathasan, Lee A Denson, Jeffrey S Hyams, Marla C Dubinsky
Background: In contrast to pediatric Crohn's disease (CD), little is known in pediatric ulcerative colitis (UC) about the relationship between disease phenotype and serologic reactivity to microbial and other antigens. Aim: The aim of this study was to examine disease phenotype and serology in a well-characterized inception cohort of children newly diagnosed with UC during the PROTECT Study (Predicting Response to Standardized Pediatric Colitis Therapy). Methods: Patients were recruited from 29 participating centers...
April 30, 2018: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/29706011/clinical-usefulness-of-the-faecal-calprotectin-test-in-suspected-paediatric-inflammatory-bowel-disease
#12
Anthony K Akobeng
AIM: The faecal calprotectin (FC) test is increasingly being used in clinical practice to help select children with gastrointestinal symptoms who might have inflammatory bowel disease (IBD) and benefit from endoscopies. We provide an overview of the advantages and limitations of the FC test. METHODS: PubMed was searched for meta-analyses that had investigated the diagnostic accuracy of the FC test and the pooled sensitivity and specificity for distinguishing IBD from non-IBD patients were used to calculate likelihood ratios...
April 29, 2018: Acta Paediatrica
https://www.readbyqxmd.com/read/29695325/cruciate-ligament-degeneration-and-stifle-joint-synovitis-in-56-dogs-with-intact-cranial-cruciate-ligaments-correlation-of-histological-findings-and-numbers-and-phenotypes-of-inflammatory-cells-with-age-body-weight-and-breed
#13
Anna-Katharina Döring, Johannes Junginger, Marion Hewicker-Trautwein
The majority of dogs with ruptured cranial cruciate ligaments (crCLs) have inflammatory changes of the stifle joint suggesting that synovitis is an important factor which is involved in the development of degenerative ligament changes. Detailed information is not available concerning the possible occurrence of inflammatory changes in the stifle joint synovium of dogs with macroscopically intact crCLs and its correlation with presence and severity of degenerative changes of the crCLs. Therefore, the purpose of this study was to examine post mortem tissue samples of 56 dogs with non-ruptured crCLs histologically for the presence of inflammatory and degenerative changes of the stifle joint synovium and cruciate ligaments, respectively...
February 2018: Veterinary Immunology and Immunopathology
https://www.readbyqxmd.com/read/29688760/effects-of-an-antioxidant-enriched-multivitamin-in-cystic-fibrosis-randomized-controlled-multicenter-trial
#14
Scott D Sagel, Umer Khan, Raksha Jain, Gavin Graff, Cori L Daines, Jordan M Dunitz, Drucy Borowitz, David M Orenstein, Ibrahim Abdulhamid, Julie Noe, John P Clancy, Bonnie Slovis, Michael J Rock, Karen S McCoy, Steven Strausbaugh, Floyd R Livingston, Konstantinos A Papas, Michele L Shaffer
RATIONALE: Cystic fibrosis (CF) is characterized by dietary antioxidant deficiencies, which may contribute to an oxidant-antioxidant imbalance and oxidative stress. OBJECTIVES: Evaluate the effects of an oral antioxidant-enriched multivitamin supplement on antioxidant concentrations, markers of inflammation and oxidative stress, and clinical outcomes. METHODS: In this investigator-initiated, multicenter, randomized, double-blind, controlled trial, 73 pancreatic insufficient CF subjects 10 years of age and older with an FEV1 between 40-100% predicted were randomized to 16 weeks of an antioxidant-enriched multivitamin or control multivitamin without antioxidant enrichment...
April 24, 2018: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/29668957/no-significant-association-between-the-fecal-microbiome-and-the-presence-of-irritable-bowel-syndrome-type-symptoms-in-patients-with-quiescent-inflammatory-bowel-disease
#15
Oliver Shutkever, David J Gracie, Caroline Young, Henry M Wood, Morag Taylor, P John Hamlin, Alexander C Ford, Philip Quirke
Background: The microbiome is implicated in the pathogenesis of inflammatory bowel disease (IBD) and irritable bowel syndrome (IBS). Whether a distinct microbiome profile is associated with the reporting of IBS-type symptoms in IBD patients is uncertain. We aimed to resolve this issue using a cross-sectional study design. Methods: Using clinical disease activity indices, the Rome III criteria for IBS and fecal calprotectin levels, we divided IBD patients into 4 groups: IBS-type symptoms, quiescent disease, occult inflammation, and active disease...
April 13, 2018: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/29668922/circulating-and-fecal-micrornas-as-biomarkers-for-inflammatory-bowel-diseases
#16
Katharina Schönauen, Nha Le, Ulrike von Arnim, Christian Schulz, Peter Malfertheiner, Alexander Link
Background: Assessment of the disease activity in inflammatory bowel disease (IBD) is essential for adequate treatment management and reliable noninvasive biomarkers for verification of mucosal healing are still needed. MicroRNAs (miRNAs) are differentially expressed in IBD and cancer. We aimed to evaluate the potential of circulating and fecal miRNAs as diagnostic biomarkers for IBD. Methods: In this proof-of-principle study we used 2 independent patient cohorts...
April 12, 2018: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/29665135/hepatocellular-carcinoma-is-associated-with-gut-microbiota-profile-and-inflammation-in-non-alcoholic-fatty-liver-disease
#17
Francesca Romana Ponziani, Sherrie Bhoori, Chiara Castelli, Lorenza Putignani, Licia Rivoltini, Federica Del Chierico, Maurizio Sanguinetti, Daniele Morelli, Francesco Paroni Sterbini, Valentina Petito, Sofia Reddel, Riccardo Calvani, Chiara Camisaschi, Anna Picca, Alessandra Tuccitto, Antonio Gasbarrini, Maurizio Pompili, Vincenzo Mazzaferro
The gut-liver axis plays a pivotal role in the pathogenesis of non-alcoholic fatty liver disease (NAFLD), which is the third cause of hepatocellular carcinoma (HCC) worldwide. However, the link between gut microbiota and hepatocarcinogenesis remains to be clarified. The aim of this study is to explore what features of the gut microbiota are associated with HCC in cirrhotic patients with NAFLD. A consecutive series of patients with NAFLD-related cirrhosis and HCC (group 1: 21 patients), NAFLD-related cirrhosis without HCC (group 2: 20 patients) and healthy controls (group 3: 20 patients) was studied for gut microbiota profile, intestinal permeability, inflammatory status and circulating mononuclear cells...
April 17, 2018: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/29659256/initial-biochemical-and-functional-evaluation-of-murine-calprotectin-reveals-ca-ii-dependence-and-its-ability-to-chelate-multiple-nutrient-transition-metal-ions
#18
Rose C Hadley, Yu Gu, Elizabeth M Nolan
Calprotectin (CP) is an abundant host-defense protein that contributes to the metal-withholding innate immune response by sequestering nutrient metal ions from microbial pathogens in the extracellular space. Over the past decade, murine models of infectious disease have advanced understanding of the physiological functions of CP and its ability to compete with microbes for essential metal nutrients. Despite this extensive work, murine CP (mCP) has not been biochemically evaluated, and structural and biophysical understanding of CP is currently limited to the human orthologue...
April 16, 2018: Biochemistry
https://www.readbyqxmd.com/read/29657832/predictive-value-of-serum-calprotectin-s100a8-a9-for-clinical-response-after-starting-or-tapering-anti-tnf-treatment-in-patients-with-rheumatoid-arthritis
#19
Lieke Tweehuysen, Nathan den Broeder, Noortje van Herwaarden, Leo A B Joosten, Peter L van Lent, Thomas Vogl, Frank H J van den Hoogen, Rogier M Thurlings, Alfons A den Broeder
Objectives: Calprotectin (S100A8/A9) has been correlated with disease activity in rheumatoid arthritis (RA). The aim of this study was to investigate the predictive value of serum calprotectin for clinical response after starting and tapering anti-tumour necrosis factor treatment in RA. Methods: Serum samples and clinical outcomes were derived from two longitudinal RA studies.At baseline (starting or tapering of adalimumab or etanercept), calprotectin levels were determined by ELISA...
2018: RMD Open
https://www.readbyqxmd.com/read/29656372/serum-calprotectin-may-reflect-inflammatory-activity-in-patients-with-active-rheumatoid-arthritis-despite-normal-to-low-c-reactive-protein
#20
Jana Hurnakova, Hana Hulejova, Jakub Zavada, Martin Komarc, Lucie Andres Cerezo, Herman Mann, Jiri Vencovsky, Karel Pavelka, Ladislav Senolt
Approximately half of patients with rheumatoid arthritis (RA) have normal C-reactive protein (CRP) levels. Calprotectin is a promising and likely more specific biomarker of disease activity than conventionally used acute phase reactants. We aimed to analyse the levels of serum calprotectin in RA patients with clinically active disease and with normal/low CRP. A total of 160 RA patients underwent clinical examination (DAS28-ESR and CDAI). The levels of calprotectin were analysed in patients with moderate to high disease activity with normal/low CRP levels and in 32 healthy subjects...
April 14, 2018: Clinical Rheumatology
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