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Lisette Binkhorst, Annemieke Sobels, Rogier Stuyt, Elsbeth M Westerman, Rachel L West
OBJECTIVE: Currently, a biosimilar of Remicade is available (CT-P13). Switching patients from Remicade to a biosimilar is still under debate, especially for patients with inflammatory bowel disease (IBD). In a retrospective study, we investigated the feasibility and safety of switching patients with IBD from Remicade to a biosimilar infliximab. PATIENTS AND METHODS: At two large general hospitals in The Netherlands, adult patients with a diagnosis of Crohn's disease or ulcerative colitis being treated with Remicade were asked to switch to the biosimilar infliximab (CT-P13)...
March 13, 2018: European Journal of Gastroenterology & Hepatology
Magdalena Kopec-Medrek, Eugene J Kucharz
BACKGROUND: Fibulin-3 (Fib-3) is a new potential biomarker of articular cartilage metabolism. OBJECTIVES: The aim of the study was to evaluate the effect of anti-TNF therapy on serum fibulin-3, cartilage oligomeric matrix protein (COMP), procollagen II C-propeptide (PIICP), and urinary C-terminal telopeptide of type II collagen (CTX-II) levels in relation to calprotectin (MRP8/14) and disease activity in rheumatoid arthritis patients. MATERIAL AND METHODS: In the study, 35 female patients with rheumatoid arthritis (RA) were investigated...
March 13, 2018: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
Joseph P Zackular, Eric P Skaar
Clostridium difficile in one of the most commonly reported nosocomial pathogens worldwide. Beyond antibiotic use, little is known about the host, microbiota, and environmental factors that contribute to susceptibility to and severity of C. difficile infection (CDI). We recently observed that in a mouse model of CDI, excess dietary zinc (Zn) alters the gut microbiota and decreases resistance to CDI. Moreover, we determined that high levels of Zn exacerbate C. difficile-associated disease and calprotectin-mediated Zn limitation is an essential host response to infection...
March 13, 2018: Gut Microbes
Zora Váradyová, Dominika Mravčáková, Michal Babják, Magdalena Bryszak, Ľubomíra Grešáková, Klaudia Čobanová, Svetlana Kišidayová, Iveta Plachá, Alžbeta Königová, Adam Cieslak, Sylwester Slusarczyk, Lukasz Pecio, Mariusz Kowalczyk, Marián Várady
BACKGROUND: The gastrointestinal parasitic nematode Haemonchus contortus is a pathogenic organism resistant to several anthelmintics. This study assessed the efficacy of a medicinal herbal mixture (Herbmix) and organic zinc, as an essential trace element for the proper functioning of both unspecific and specific immune defensive mechanisms, against experimental infections with H. contortus in lambs. All lambs were infected orally with approximately 5000 third-stage larvae of a strain of H...
March 9, 2018: BMC Veterinary Research
Despina D Briana, Ariadne Malamitsi-Puchner
No abstract text is available yet for this article.
March 9, 2018: Current Medical Research and Opinion
M Koray, B Atalay, S Akgul, F S Oguz, G Mumcu, A Saruhanoglu
Aim: Recurrent aphthous stomatitis (RAS) is an inflammatory condition of the oral mucosa. The etiology of RAS remains unclear. Calprotectin is a major cytoplasmic protein contained in granulocytes, monocytes/macrophages and epithelial cells, and its level is increased body fluids in some inflammatory diseases. The aim is to determine the relationship between salivary calprotectin and RAS. Material and Methods: In the cross-sectional study, 67 patients with active lesions of RAS (F/M: 43/24, mean age: 30...
March 2018: Nigerian Journal of Clinical Practice
Warapan Nakayuenyongsuk, Megan Christofferson, David K Stevenson, Karl Sylvester, Henry C Lee, K T Park
OBJECTIVE: To establish baseline trends in fecal calprotectin, a protein excreted into the stool when there is neutrophilic inflammation in the bowel, in infants at risk for necrotizing enterocolitis (NEC). STUDY DESIGN: We performed a prospective observational cohort study in infants with a birth weight of <1500 g without existing bowel disease at a level IV neonatal intensive care unit from October 2015 to September 2016. Stools were collected once daily for 30 days or until 32 weeks postmenstrual age and processed using the Fecal Calprotectin High Range Quantitative Quantum Blue assay...
March 6, 2018: Journal of Pediatrics
Anke Heida, Els Van de Vijver, Don van Ravenzwaaij, Stephanie Van Biervliet, Thalia Z Hummel, Zehre Yuksel, Gieneke Gonera-de Jong, Renate Schulenberg, Anneke Muller Kobold, Patrick Ferry van Rheenen
OBJECTIVE: Calgranulin-C (S100A12) is a new faecal marker of inflammation that is potentially more specific for inflammatory bowel disease (IBD) than calprotectin, since it is only released by activated granulocytes. We compared calgranulin-C and calprotectin to see which of the two tests best predicted IBD in children with chronic abdominal pain and diarrhoea. DESIGN: Delayed-type cross-sectional diagnostic study. SETTING AND PATIENTS: Previously undiagnosed patients aged 6-17 years, who were seen in paediatric clinics in the Netherlands and Belgium, sent in a stool sample for analysis...
March 7, 2018: Archives of Disease in Childhood
G J Walker, L Moore, N Heerasing, P Hendy, M H Perry, T J McDonald, T Debenham, R Bethune, C Bewshea, C Hyde, G A Heap, A Singh, C Calvert, N A Kennedy, J R Goodhand, T Ahmad
BACKGROUND: Primary care faecal calprotectin testing distinguishes inflammatory bowel disease (IBD) from functional gut disorder in young patients presenting with abdominal symptoms; however, previous evaluations have excluded patients with alarm symptoms. AIMS: We sought to evaluate the diagnostic accuracy of calprotectin to distinguish IBD from functional gut disorder in young adults in whom general practitioners (GPs) suspected IBD; including patients reporting gastrointestinal alarm symptoms...
March 5, 2018: Alimentary Pharmacology & Therapeutics
Heidi Kammerlander, Jan Nielsen, Jens Kjeldsen, Torben Knudsen, Kim Oren Gradel, Sonia Friedman, Bente Mertz Nørgård
Background: Fecal calprotectin (FC) is a biomarker used for assessing disease activity among IBD patients. Sparse knowledge exists as to whether FC correlates with clinical disease activity during pregnancy. Our aim was to assess FC and selected biomarkers in women with moderate-severe IBD and correlate them with clinical disease activity scores in pregnant women. Methods: We identified a nationwide cohort of 219 singleton pregnancies in women with moderate-severe disease (all treated with anti-tumor recrosis factor-α [anti-TNF-α] therapy during pregnancy), and we reviewed the medical records to extract clinical details and information on biomarkers...
February 28, 2018: Inflammatory Bowel Diseases
Inbar Nakar, Gili Focht, Peter Church, Thomas D Walters, Guila Abitbol, Sudha Anupindi, Laureline Berteloot, Jessie M Hulst, Frank Ruemmele, Daniel A Lemberg, Steven T Leach, Ruth Cytter, Mary-Louise Greer, Anne M Griffiths, Dan Turner
BACKGROUND & AIMS: Bowel healing is an important goal of therapy for patients with Crohn's disease (CD). Although there have been many studies of mucosal healing, transmural healing (in the bowel wall) has not been investigated in children. We analyzed data from the ImageKids study to determine associations among mucosal and transmural healing and levels of calprotectin and c-reactive protein in children with CD. METHODS: We collected data from a multi-center study designed to develop 2 magnetic resonance enterography (MRE)-based measures for children with CD (6-18 years old)...
March 1, 2018: Clinical Gastroenterology and Hepatology
Takayuki Yamamoto, Takahiro Shimoyama, Satoru Umegae, Koichi Matsumoto
Achieving endoscopic remission or decreasing the level of fecal biomarkers as an ideal therapeutic goal in ulcerative colitis has not been determined. This prospective study was to compare the clinical relevance of endoscopic score with fecal biomarkers for predicting relapse after clinical remission and mucosal healing (MH). One hundred and sixty-four patients who achieved clinical remission and MH (Mayo endoscopic subscore (MES) 0 or 1) were included. At entry, fecal samples were collected for the measurement of calprotectin, lactoferrin, and hemoglobin...
February 20, 2018: Clinical and Translational Gastroenterology
Juan Egea-Valenzuela, Begoña González Suárez, Cristian Sierra Bernal, José Francisco Juanmartiñena Fernández, Marisol Luján-Sanchís, Mileidis San Juan Acosta, Blanca Martínez Andrés, Vicente Pons Beltrán, Violeta Sastre Lozano, Cristina Carretero Ribón, Félix de Vera Almenar, Joaquín Sánchez Cuenca, Fernando Alberca de Las Parras, Cristina Rodríguez de Miguel, Julio Valle Muñoz, Ignacio Férnandez-Urién Sainz, Carolina Torres González, Pilar Borque Barrera, Enrique Pérez-Cuadrado Robles, Noelia Alonso Lázaro, Pilar Martínez García, César Prieto de Frías, Fernando Carballo Álvarez
BACKGROUND: Capsule endoscopy (CE) is the first-line investigation in cases of suspected Crohn's disease (CD) of the small bowel, but the factors associated with a higher diagnostic yield remain unclear. OBJECTIVE: Our aim is to develop and validate a scoring index to assess the risk of the patients in this setting on the basis of biomarkers. PATIENTS AND METHODS: Data on fecal calprotectin, C-reactive protein, and other biomarkers from a population of 124 patients with suspected CD of the small bowel studied by CE and included in a PhD study were used to build a scoring index...
February 27, 2018: European Journal of Gastroenterology & Hepatology
T S Chew, J C Mansfield
Crohn's disease and ulcerative colitis are chronic inflammatory disorders affecting the gastrointestinal tract. Faecal calprotectin is a protein complex of the S-100 family of calcium-binding proteins present in inflammatory cells that can be measured in stool samples, which act as a biomarker for bowel inflammation. Elevated faecal calprotectin has been shown to reflect the presence of ongoing mucosal inflammation, which improves with mucosal healing. The aim of this review was to evaluate the available evidence on the ability of faecal calprotectin to predict a relapse in inflammatory bowel disease...
January 2018: Frontline Gastroenterology
A B Friedman, S J Brown, P Bampton, M L Barclay, A Chung, F A Macrae, J McKenzie, J Reynolds, P R Gibson, S B Hanauer, M P Sparrow
BACKGROUND: Thiopurine hypermethylation towards 6-methylmercaptopurine (6MMP) instead of 6-thioguanine nucleotides (6TGN) is associated with inefficacy in patients with IBD. Allopurinol reverses such hypermethylation. AIMS: To prospectively determine efficacy of allopurinol-thiopurine combination and to compare 2 doses of allopurinol. DESIGN: In a multicentre, double-blind trial, patients with clinically active or steroid-dependent IBD and thiopurine shunting were randomised to 50 or 100 mg/d allopurinol and 25% of their screening thiopurine dose, which was subsequently optimised, aiming for 6TGN of 260-500 pmol/8x108 RBCs...
February 21, 2018: Alimentary Pharmacology & Therapeutics
Wing Yan Mak, Anthony Buisson, Michael J Andersen, Donald Lei, Joel Pekow, Russell D Cohen, Stacy A Kahn, Bruno Pereira, David T Rubin
BACKGROUND: Persistent active endoscopic and histological inflammation is associated with poorer outcomes in ulcerative colitis (UC). Fecal calprotectin is a surrogate marker of endoscopic and histological remission. AIMS: To confirm the correlation between fecal calprotectin and endoscopic or histological disease activity and to define the optimal cutoff value to detect endoscopic and histological remission. METHODS: From a prospectively maintained database, we analyzed 61 UC patients who had fecal calprotectin measurement and endoscopy performed within 1 month...
February 22, 2018: Digestive Diseases and Sciences
Hamid Yousuf, Umair Aleem, Roisin Egan, Pardeep Maheshwari, Jafaar Mohamad, Deidre McNamara
BACKGROUND: Approximately 10% of Crohn's disease (CD) patients have this disease affecting the small bowel (SB) beyond the reach of Ileo-colonoscopy. Capsule endoscopy (SBCE) is the recommended investigation for SB disease. An accurate and inexpensive biomarker would help identify at-risk patients. AIM: To examine the efficacy of faecal calprotectin (FC) and C-reactive protein (CRP) as predictors of SBCE findings in suspected and known CD. METHODS: A prospective observational study...
February 21, 2018: Digestive Diseases
Arno R Bourgonje, Julius Z H von Martels, Paul de Vos, Klaas Nico Faber, Gerard Dijkstra
BACKGROUND: Patient-reported symptoms and endoscopic disease activity do not correlate well in Crohn's disease (CD). This warrants the need for reliable biomarkers to early detect active intestinal inflammation. Currently, the fecal calprotectin level is the most commonly used biomarker for inflammatory activity in CD. However, the diagnostic accuracy of the fecal calprotectin level is not fully efficacious and diagnosis may be further improved by the identification of other biomarkers for active CD...
2018: PloS One
Nicholas A Kennedy, Christopher A Lamb, Susan H Berry, Alan W Walker, John Mansfield, Miles Parkes, Rachel Simpkins, Mark Tremelling, Sarah Nutland, Julian Parkhill, Chris Probert, Georgina L Hold, Charlie W Lees
Background/Aims: Current models of Crohn's disease (CD) describe an inappropriate immune response to gut microbiota in genetically susceptible individuals. NOD2 variants are strongly associated with development of CD, and NOD2 is part of the innate immune response to bacteria. This study aimed to identify differences in fecal microbiota in CD patients and non-IBD controls stratified by NOD2 genotype. Methods: Patients with CD and non-IBD controls of known NOD2 genotype were identified from patients in previous UK IBD genetics studies and the Cambridge bioresource (genotyped/phenotyped volunteers)...
February 15, 2018: Inflammatory Bowel Diseases
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