keyword
MENU ▼
Read by QxMD icon Read
search

Calprotectin

keyword
https://www.readbyqxmd.com/read/29338066/endoscopic-scoring-indices-for-evaluation-of-disease-activity-in-ulcerative-colitis
#1
REVIEW
Nadia Mohammed Vashist, Mark Samaan, Mahmoud H Mosli, Claire E Parker, John K MacDonald, Sigrid A Nelson, G Y Zou, Brian G Feagan, Reena Khanna, Vipul Jairath
BACKGROUND: Endoscopic assessment of mucosal disease activity is routinely used to determine eligibility and response to therapy in clinical trials of ulcerative colitis. The operating properties of the existing endoscopic scoring indices are unclear. OBJECTIVES: A systematic review was undertaken to evaluate the development and operating characteristics of endoscopic scoring indices for the evaluation of ulcerative colitis. SEARCH METHODS: We searched MEDLINE, Embase and CENTRAL from inception to 5 July 2016...
January 16, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29336925/a-novel-inactivated-vaccine-against-lawsonia-intracellularis-induces-rapid-induction-of-humoral-immunity-reduction-of-bacterial-shedding-and-provides-robust-gut-barrier-function
#2
F Roerink, C L Morgan, S M Knetter, M-H Passat, A L Archibald, T Ait-Ali, E L Strait
Porcine proliferative ileitis is a major economic burden for the swine industry, affecting growing pigs and young adult pigs. In this study, the protective efficacy of an inactivated, injectable whole-cell bacteria vaccine against L. intracellularis - Porcilis® Ileitis was evaluated under field conditions. Eighty-five, three-week-old pigs on a commercial farrow-to-finish farm were vaccinated by the intramuscular route, either with a dose of injectable vaccine, or with saline. A subset of vaccinates and control pigs were necropsied at 21 days post-challenge...
January 11, 2018: Vaccine
https://www.readbyqxmd.com/read/29334728/changing-treatment-paradigms-for-the-management-of-inflammatory-bowel-disease
#3
REVIEW
Jong Pil Im, Byong Duk Ye, You Sun Kim, Joo Sung Kim
Inflammatory bowel disease (IBD) is a chronic and progressive inf lammatory condition of the gastrointestinal tract causing bowel damage, hospitalizations, surgeries, and disability. Although there has been much progress in the management of IBD with established and evolving therapies, most current approaches have failed to change the natural course. Therefore, the treatment approach and follow-up of patients with IBD have undergone a significant change. Usage of immunosuppressants and/or biologics early during the course of the disease, known as top-down or accelerated step-up approach, was shown to be superior to conventional management in patients who had been recently diagnosed with IBD...
January 2018: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/29329619/hepatic-fibropoiesis-in-dogs-naturally-infected-with-leishmania-leishmania-infantum-treated-with-liposome-encapsulated-meglumine-antimoniate-and-allopurinol
#4
R S Castro, I F G de Amorim, R A Pereira, S M Silva, L J Pinheiro, A J W Pinto, E G Azevedo, C Demicheli, M M V Caliari, D M Mosser, M S M Michalick, Frédéric J G Frezard, Wagner L Tafuri
Hepatic fibropoiesis in canine visceral leishmaniasis (CVL) were evaluated by histological (morphometrical collagen deposition) and immunohistochemical assays characterizing alpha-actin (α-SMA), vimentin, calprotectin (L1 antigen), and TGF-β in 46 naturally infected dogs with Leishmania infantum treated with liposome-encapsulated meglumine antimoniate and allopurinol separately and in combination. Six treatment groups were defined: meglumine antimoniate encapsulated in nanometric liposomes (LMA), allopurinol (ALLOP); liposome-encapsulated meglumine antomoniate combined with allopurinol (LMA+ALLOP); empty liposomes (LEMP); empty liposomes combined with allopurinol (LEMP+ALLOP) and saline...
January 30, 2018: Veterinary Parasitology
https://www.readbyqxmd.com/read/29328869/inflammatory-bowel-diseases-and-fermentable-oligosaccharides-disaccharides-monosaccharides-and-polyols-an-overview
#5
Sandra Maria Barbalho, Ricardo de Alvares Goulart, Ana Luíza de Carvalho Aranão, Pamela Grazielle Correa de Oliveira
Inflammatory bowel diseases (IBDs) are mainly represented by ulcerative colitis and Crohn's disease, and the increase in the incidence tends to follow the rapid industrialization and lifestyle of modern societies. FODMAP (fermentable oligosaccharides, disaccharides, monosaccharides, and polyols) consist of molecules that are poorly absorbed in the small intestine and are fermented by bacteria in the colon leading to symptoms such as bloating, flatulence, diarrhea, and abdominal pain. Reduction of the ingestion of FODMAP could reduce the symptoms and improve the quality of life...
January 12, 2018: Journal of Medicinal Food
https://www.readbyqxmd.com/read/29321158/response-to-calprotectin-is-not-independent-from-baseline-erosion-in-predicting-radiological-progression-in-early-rheumatoid-arthritis-by-chevreau-et-al
#6
Maria Karolina Jonsson, Nina Paulshus Sundlisæter, Hilde Haugedal Nordal, Hilde Berner Hammer, Anna-Birgitte Aga, Désirée van der Heijde, Tore Kristian Kvien, Bjørg-Tilde Svanes Fevang, Siri Lillegraven, Espen Andre Haavardsholm
No abstract text is available yet for this article.
January 10, 2018: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/29317275/increasing-infliximab-dose-based-on-symptoms-biomarkers-and-serum-drug-concentrations-does-not-increase-clinical-endoscopic-or-corticosteroid-free-remission-in-patients-with-active-luminal-crohn-s-disease
#7
Geert D'Haens, Severine Vermeire, Guy Lambrecht, Filip Baert, Peter Bossuyt, Benjamin Pariente, Anthony Buisson, Yoram Bouhnik, Jérôme Filippi, Janneke Vander Woude, Philippe Van Hootegem, Jacques Moreau, Edouard Louis, Denis Franchimont, Martine De Vos, Fazia Mana, Laurent Peyrin-Biroulet, Hedia Brixi, Matthieu Allez, Philip Caenepeel, Alexandre Aubourg, Bas Oldenburg, Marieke Pierik, Ann Gils, Sylvie Chevret, David Laharie
BACKGROUND & AIMS: A combination of infliximab and immunomodulators is the most efficacious treatment for Crohn's disease (CD). Patients have the best outcomes when their serum concentrations of these drugs are above a determined therapeutic threshold. We performed a prospective, randomized trial to determine whether therapeutic drug monitoring (TDM) to maintain serum levels of infliximab above 3 μg/mL produced higher rates of clinical and endoscopic remission than adapting dose based only on symptoms...
January 6, 2018: Gastroenterology
https://www.readbyqxmd.com/read/29310593/how-disease-extent-can-be-included-in-the-endoscopic-activity-index-of-ulcerative-colitis-the-panmayo-score-a-promising-scoring-system
#8
Anita Bálint, Klaudia Farkas, Zoltán Szepes, Ferenc Nagy, Mónika Szűcs, László Tiszlavicz, Renáta Bor, Ágnes Milassin, Mariann Rutka, Anna Fábián, Tamás Molnár
BACKGROUND: Colonoscopy plays crucial role in the establishment of the diagnosis, management and follow-up of ulcerative colitis (UC). None of the currently widely used endoscopic scores consider disease extent, and therefore do not correlate with the real severity of UC. Our aim was to assess the accuracy of a new score, the Pancolonic Modified Mayo Score that can reflect not only the severity, but the extent of active UC. METHODS: One hundred and four UC patients were enrolled in this prospective study...
January 8, 2018: BMC Gastroenterology
https://www.readbyqxmd.com/read/29290660/efficacy-of-noninvasive-evaluations-in-monitoring-inflammatory-bowel-disease-activity-a-prospective-study-in-china
#9
Jin-Min Chen, Tao Liu, Shan Gao, Xu-Dong Tong, Fei-Hong Deng, Biao Nie
AIM: To optimize the efficacy of noninvasive evaluations in monitoring the endoscopic activity of inflammatory bowel disease (IBD). METHODS: Fecal calprotectin (FC), clinical activity index (CDAI or CAI), C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), and procalcitonin (PCT) were measured for 136 IBD patients. Also, FC was measured in 25 irritable bowel syndrome (IBS) patients that served as controls. Then, endoscopic activity was determined by other two endoscopists for colonic or ileo-colonic Crohn's disease (CICD) with the "simple endoscopic score for Crohn's disease" (SES-CD), CD-related surgery patients with the Rutgeerts score, and ulcerative colitis (UC) with the Mayo score...
December 14, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29283308/normal-values-for-calprotectin-in-stool-samples-of-infants-from-the-population-based-longitudinal-born-into-life-study
#10
Sari Peura, Tove Fall, Catarina Almqvist, Ellika Andolf, Anna Hedman, Göran Pershagen, Johanna Helmersson-Karlqvist, Anders Larsson
Faecal calprotectin is a protein used as a diagnostic marker for inflammatory bowel diseases. We determined upper limits for normal calprotectin values for neonatal, 6, 12 and 24 months old children using a turbidimetric immunoassay in a cohort of Swedish children. The advantage of the method is that opposite to previously used enzyme-linked immunosorbent assay (ELISA) method, it enables measuring single samples, and thus, shortens the analysis time significantly. There were 72 samples (41.7% female) collected neonatally, 63 samples (34...
December 28, 2017: Scandinavian Journal of Clinical and Laboratory Investigation
https://www.readbyqxmd.com/read/29282492/the-use-of-fecal-calprotectin-levels-in-the-fontan-population
#11
Carlos Miranda, Anas Taqatqa, Adrian Chapa-Rodriguez, Jacob P Holton, Sawsan M Awad
The Fontan procedure was first performed in the seventies as a palliation for patients with single ventricle physiology. A feared complication after a Fontan procedure is the development of protein losing enteropathy (PLE). Systemic inflammation has a negative effect on the intestinal barrier integrity, which has supported the use of steroids in this setting. To the best of our knowledge there are no studies linking intestinal inflammation in patients with PLE after Fontan. The objective of this study was to identify the presence of intestinal inflammation measured by FC in patients with PLE after a Fontan procedure...
December 28, 2017: Pediatric Cardiology
https://www.readbyqxmd.com/read/29278951/calprotectin-s100a8-a9-should-preferably-be-measured-in-edta-plasma-results-from-a-longitudinal-study-of-patients-with-rheumatoid-arthritis
#12
Hilde Haugedal Nordal, Magne K Fagerhol, Anne-Kristine Halse, Hilde Berner Hammer
Calprotectin (S100A8/A9), a protein expressed in neutrophils and monocytes/macrophages in circulation and inflamed tissue, is associated with measures of disease activity in rheumatoid arthritis (RA) patients both when measured in ethylenediaminetetraacetic acid (EDTA)-plasma and in serum. We wanted to explore if EDTA-plasma or serum should be preferred for calprotectin as a marker of disease activity. Calprotectin was analysed in EDTA-plasma and serum by enzyme-linked immunosorbent assay (ELISA) at baseline in 141 RA patients, starting biologic disease-modifying anti-rheumatic drugs (bDMARDs), and after three months...
December 27, 2017: Scandinavian Journal of Clinical and Laboratory Investigation
https://www.readbyqxmd.com/read/29273710/urinary-potassium-is-a-potential-biomarker-of-disease-activity-in-ulcerative-colitis-and-displays-in-vitro-immunotolerant-role
#13
Sandeep Goyal, Ritika Rampal, Saurabh Kedia, Sandeep Mahajan, Sawan Bopanna, Devesh P Yadav, Saransh Jain, Amit Kumar Singh, Md Nahidul Wari, Govind Makharia, Amit Awasthi, Vineet Ahuja
We evaluated the in-vitro effect of potassium on CD4+ T cells and the role of urinary potassium as a potential biomarker of disease activity in patients with ulcerative colitis (UC). This prospective observational cohort study included healthy controls (n = 18) and UC patients [n = 30, median age: 40 (IQR: 28-46) years, 17 males)] with active disease(assessed by Mayo score) from September 2015-May 2016. Twenty-four hours urinary potassium along with fecal calprotectin (FCP) were estimated in UC patients (at baseline and follow-up after 3-6 months) and controls...
December 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29248204/intestinal-permeability-and-m%C3%A3-ni%C3%A3-re-s-disease
#14
F Di Berardino, D Zanetti, E Ciusani, C Caccia, V Leoni, U De Grazia, E Filipponi, L Elli
PURPOSE: Ménière disease (MD) is a multifactorial chronic disabling condition characterized by episodic vertigo, ear fullness, and hearing loss. MD patients often complain of aspecific gastrointestinal symptoms associated with autonomic dysregulation, frequently outweighed by the otological manifestations. Dietary modifications have been reported to improve the typical MD symptoms in some cases. Our purpose was to test the urinary levels of lactulose and mannitol (double sugar test) and the fecal calprotectin, both markers of altered intestinal permeability, in subjects with definite MD in an active and inactive stage...
December 5, 2017: American Journal of Otolaryngology
https://www.readbyqxmd.com/read/29240011/fecal-calprotectin-test-performed-at-home-a-prospective-study-of-pediatric-patients-with-inflammatory-bowel-disease
#15
Maija Piekkala, Henrik Alfthan, Laura Merras-Salmio, Anne Puustinen Wikström, Kaarina Heiskanen, Tytti Jaakkola, Paula Klemetti, Martti Färkkilä, Kaija-Leena Kolho
OBJECTIVES: Measuring fecal calprotectin (FC) in a laboratory is time-consuming and that is why home tests have been developed. We studied the use of an FC home test in pediatric patients with inflammatory bowel disease (PIBD) in real-life settings. METHODS: The patients were asked to perform the IBDoc® FC home test monthly for six months and to report their clinical disease activity at testing. However, clinical decision-making was guided by routine FC enzyme-linked immunosorbent assay (ELISA) for patients with raised IBDoc® values...
December 12, 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/29234915/the-impact-of-exertional-heat-stress-on-gastrointestinal-integrity-gastrointestinal-symptoms-systemic-endotoxin-and-cytokine-profile
#16
Rhiannon M J Snipe, Anthony Khoo, Cecilia M Kitic, Peter R Gibson, Ricardo J S Costa
PURPOSE: The study aimed to determine the effects of exertional-heat stress on gastrointestinal integrity, symptoms, systemic endotoxin and inflammatory responses; and assess the relationship between changes in body temperature and gastrointestinal perturbations. METHODS: Ten endurance runners completed 2 h running at 60% [Formula: see text]O2max in hot (HOT: 35 °C) and temperate (TEMP: 22 °C)-ambient conditions. Rectal temperature (T re) and gastrointestinal symptoms were recorded every 10 min during exercise...
December 12, 2017: European Journal of Applied Physiology
https://www.readbyqxmd.com/read/29234707/point-of-care-testing-of-fecal-calprotectin-as-a-substitute-for-routine-laboratory-analysis
#17
Julie Hejl, Klaus Theede, Brian Møllgren, Kirsten Vikkelsø Madsen, Ashraf Heidari, Anna Á Steig, Mogens Fenger
Objectives: Fecal calprotectin (FC) is widely used to monitor the activity of inflammatory bowel disease (IBD) and to tailor medical treatment to disease activity. Laboratory testing of fecal samples may have a turnaround time of 1-2 weeks, whereas FC home testing allows results within hours and thus enables a rapid response to clinical deterioration. Design and methods: Fifty-five stool samples were analyzed by the IBDoc® Calprotectin Home Testing kit and the BÜHLMANN fCAL® turbo assay on a Roche Cobas 6000 c501...
March 2018: Practical Laboratory Medicine
https://www.readbyqxmd.com/read/29228799/calprotectin-in-patients-with-chronic-rheumatoid-arthritis-correlates-with-disease-activity-and-responsiveness-to-methotrexate
#18
Ulla Bregendahl Nielsen, Laerke Valsøe Bruhn, Torkell Ellingsen, Kristian Stengaard-Pedersen, Nete Hornung
OBJECTIVE: Calprotectin (myeloid-related protein 8/14) is elevated in inflammatory diseases and a correlation of serum calprotectin and disease activity in rheumatoid arthritis (RA) has been shown. In this study, we investigated plasma calprotectin as a disease marker in patients with chronic RA treated with methotrexate (MTX) monotherapy and compared plasma calprotectin with C-reactive protein (CRP) in this matter. METHODS: Seventy-six patients with chronic RA were included in this open prospective study and of these 40 were included prior to initiation of MTX therapy...
December 11, 2017: Scandinavian Journal of Clinical and Laboratory Investigation
https://www.readbyqxmd.com/read/29228230/the-efficacy-of-home-telemonitoring-versus-conventional-follow-up-a-randomised-controlled-trial-among-teenagers-with-inflammatory-bowel-disease
#19
Anke Heida, Alie Dijkstra, Anneke Muller Kobold, John Rossen, Angelika Kindermann, Freddy Kokke, Tim de Meij, Obbe Norbruis, Rinse Weersma, Margreet Wessels, Thalia Hummel, Hankje Escher, Herbert van Wering, Daniëlle Hendriks, Luisa Mearin, Henk Groen, Henkjan Verkade, Patrick van Rheenen
Background and aims: Conventional follow-up of teenagers with inflammatory bowel diseases (IBD) is done during scheduled outpatient visits regardless of how well the patient feels. We designed a telemonitoring strategy for early recognition of flares and compared its efficacy with conventional follow-up. Methods: Multicentre randomised trial in patients aged 10-19 years with IBD in clinical remission at baseline. Participants assigned to telemonitoring received automated alerts to complete a symptom score and send a stool sample for calprotectin measurement...
December 8, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/29225617/fecal-calprotectin-a-reliable-predictor-of-mucosal-healing-after-treatment-for-active-ulcerative-colitis
#20
Vendel Kristensen, Arne Røseth, Tahir Ahmad, Viggo Skar, Bjørn Moum
Objectives: Mucosal healing has become the new goal of treatment in ulcerative colitis. Fecal calprotectin has been demonstrated to differentiate between mucosal inflammation and mucosal healing. With this project, we investigated whether a reduction in f-calprotectin to <250 μg/g after medical treatment for active ulcerative colitis could predict mucosal healing. Material and Methods: After a baseline colonoscopy, 20 patients with active ulcerative colitis were followed with consecutive fecal calprotectin monthly until two measurements of fecal calprotectin < 250 μg/g or a maximum follow-up of 12 months...
2017: Gastroenterology Research and Practice
keyword
keyword
26131
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"