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Calprotectin

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https://www.readbyqxmd.com/read/29151693/endoscopic-balloon-dilation-of-crohn-s-disease-strictures-safety-efficacy-and-clinical-impact
#1
Susana Lopes, Eduardo Rodrigues-Pinto, Patrícia Andrade, Joana Afonso, Todd H Baron, Fernando Magro, Guilherme Macedo
AIM: To evaluate the incidence of anastomotic strictures after intestinal resection in Crohn's disease (CD), demonstrate long-term efficacy and safety of endoscopic balloon dilation (EBD) in CD strictures and its impact on the diagnosis of subclinical postoperative endoscopic recurrence. METHODS: Retrospective single tertiary center study based on prospectively collected data between 2010 and 2015 including anastomotic and non-anastomotic strictures. RESULTS: 29% of 162 CD patients included developed an anastomotic stricture...
November 7, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29151692/fecal-calprotectin-measurement-is-a-marker-of-short-term-clinical-outcome-and-presence-of-mucosal-healing-in-patients-with-inflammatory-bowel-disease
#2
Athanasios Kostas, Spyros I Siakavellas, Charalambos Kosmidis, Anna Takou, Joanna Nikou, Georgios Maropoulos, John Vlachogiannakos, George V Papatheodoridis, Ioannis Papaconstantinou, Giorgos Bamias
AIM: To evaluate the utility of fecal calprotectin (FC) in predicting relapse and endoscopic activity during follow-up in an inflammatory bowel disease (IBD) cohort. METHODS: All FC measurements that were obtained during a 3-year period from patients with inflammatory bowel disease in clinical remission were identified. Data regarding the short-term (6 mo) course of the disease were extracted from the medical files. Exclusion criteria were defined as: (1) An established flare of the disease at the time of FC measurement, (2) Loss to follow up within 6 mo from baseline FC measurement, and, (3) Insufficient data on file...
November 7, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29151253/a-two-week-fecal-microbiota-transplantation-course-in-pediatric-patients-with-inflammatory-bowel-disease
#3
Katarzyna Karolewska-Bochenek, Pawel Grzesiowski, Aleksandra Banaszkiewicz, Agnieszka Gawronska, Maria Kotowska, Marcin Dziekiewicz, Piotr Albrecht, Andrzej Radzikowski, Izabella Lazowska-Przeorek
Dysbiosis plays a major role in the etiology of inflammatory bowel disease (IBD). Fecal microbiota transplantation (FMT) is a new promising option for IBD treatment. We aimed to assess the effectiveness of a two-week FMT course in children with IBD. Ten patients, 10-17 years of age with moderate to severe IBD received a course of eight doses of freshly prepared FMT via a naso-duodenal tube or gastroscopy. All of the patients had pancolitis. There were eight cases of ulcerative colitis (UC) and two of Crohn's disease (CD)...
November 19, 2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29147134/the-clinical-course-after-glucocorticoid-treatment-in-patients-with-inflammatory-bowel-disease-is-linked-to-suppression-of-the-hypothalamic-pituitary-adrenal-axis-a-retrospective-observational-study
#4
Aghil Ibrahim, Per Dahlqvist, Tommy Olsson, David Lundgren, Mårten Werner, Ole B Suhr, Pontus Karling
Background: Adrenal insufficiency (AI) secondary to treatment with glucocorticoids (GCs) is common in patients with inflammatory bowel disease (IBD), but little is known about the relationship between AI and the clinical course in IBD. The aim of the study was to compare the clinical course in IBD patients with normal adrenal function versus patients with subnormal adrenal function. Methods: A retrospective observational study on 63 patients with IBD who had performed a low-dose short Synacthen test (LDSST) (1 μg) immediately (1-7 days) after a standard course of GCs...
November 2017: Therapeutic Advances in Gastroenterology
https://www.readbyqxmd.com/read/29135821/compliance-with-fecal-calprotectin-testing-in-pediatric-inflammatory-bowel-disease-patients
#5
Karen Queliza, Michael K Wang, Richard Kellermayer
Fecal calprotectin (FC) is a highly sensitive biomarker for inflammatory bowel diseases (IBDs). Utilization of this assay has been steadily increasing. However, adherence levels for FC have yet to be examined in the pediatric IBD setting. We analyzed 100 consecutive patients diagnosed with IBD between 2014 and 2015 at Texas Children's Hospital. Fifty-six percent of patients were male and median age at diagnosis was 13.7 years. Following diagnosis of IBD, 84 patients had a minimum of one FC requested, and 95...
November 10, 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/29133349/the-role-of-calprotectin-in-withholding-zinc-and-copper-from-candida-albicans
#6
Angelique N Besold, Benjamin A Gilston, Jana N Radin, Christian Ramsoomair, Edward M Culbertson, Cissy X Li, Brendan P Cormack, Walter J Chazin, Thomas E Kehl-Fie, Valeria C Culotta
The opportunistic fungal pathogen Candida albicans acquires essential metals from the host, yet the host can sequester these micronutrients through a process known as nutritional immunity. How the host withholds metals from C. albicans was poorly understood and here we examine the role of calprotectin (CP), a transition metal binding protein. When CP depletes bioavailable Zn from the extracellular environment, C. albicans strongly upregulates ZRT1 and PRA1 for Zn import and maintains constant intracellular Zn through numerous cell divisions...
November 13, 2017: Infection and Immunity
https://www.readbyqxmd.com/read/29132736/clinical-effects-of-probiotics-in-cystic-fibrosis-patients-a-systematic-review
#7
Stephanie Van Biervliet, Dimitri Declercq, Shawn Somerset
Cystic fibrosis (CF) is characterised by a build-up of thick, intransient mucus linings of the digestive and respiratory mucosa, which disrupts digestive system functioning and microbiota composition. In view of the potential for probiotics to enhance microbiota composition in other contexts, this study investigated the current evidence for probiotics as an adjunct to usual therapy for CF. Electronic clinical databases were interrogated for human randomised, controlled, intervention trials (1985-2015) testing the effects of probiotics on clinical endpoints in CF were reviewed...
April 2017: Clinical Nutrition ESPEN
https://www.readbyqxmd.com/read/29121442/enteric-infections-in-young-children-are-associated-with-environmental-enteropathy-and-impaired-growth
#8
Christine Marie George, Vanessa Burrowes, Jamie Perin, Lauren Oldja, Shwapon Biswas, David Sack, Shahnawaz Ahmed, Rashidul Haque, Nurul Amin Bhuiyan, Tahmina Parvin, Sazzadul Islam Bhuyian, Mahmuda Akter, Shan Li, Gayathri Natarajan, Mohammad Shahnaij, Abu G Faruque, O Colin Stine
OBJECTIVE: To investigate the relationship between fecal contamination in child play spaces, enteric infections, environmental enteropathy (EE), and impaired growth among young children. METHODS: Prospective cohort study of 203 children 6-30 months of age in rural Bangladesh. Stool samples were analyzed by quantitative PCR for Shigella, Enterotoxigenic Escherichia coli (ETEC), Campylobacter jejuni, Giardia spp, and Cryptosporidium spp. Four fecal markers of intestinal inflammation were also measured: alpha-1-antitrypsin, myeloperoxidase, neopterin, and calprotectin...
November 9, 2017: Tropical Medicine & International Health: TM & IH
https://www.readbyqxmd.com/read/29121178/exploration-of-predictive-biomarkers-of-early-infliximab-response-in-acute-severe-colitis-a-prospective-pilot-study
#9
Lauren Beswick, Ourania Rosella, Gennaro Rosella, Belinda Headon, Miles P Sparrow, Peter R Gibson, Daniel R van Langenberg
Background: Outcomes of acute severe ulcerative colitis (ASUC) appear dependent on early intervention with the first and/or further infliximab(IFX) doses, though parameters to guide decision-making remain uncertain. Aim: To assess whether serum/faecal IFX levels and inflammatory biomarkers early post-IFX dose can predict ASUC outcomes. Methods: This prospective pilot study consecutively recruited inpatients with steroid-refractory ASUC, who then received 1-3 IFX rescue doses (5mg/kg/dose) per treating clinician's discretion...
November 7, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/29118554/risk-factors-for-postoperative-recurrence-of-crohn-s-disease-with-emphasis-on-surgical-predictors
#10
REVIEW
Antonios Gklavas, Dionysios Dellaportas, Ioannis Papaconstantinou
Intestinal resection for Crohn's disease is not curative and postoperative recurrence rates remain high. Early detection of indices associated with recurrence and risk stratification are fundamental for the postoperative management of patients. Early endoscopy at 6-12 months is the "gold standard" procedure, whereas other modalities such as fecal calprotectin and imaging techniques can contribute to the diagnosis of recurrence. The purpose of this review is to summarize current data regarding risk factors correlated with postoperative relapse...
2017: Annals of Gastroenterology: Quarterly Publication of the Hellenic Society of Gastroenterology
https://www.readbyqxmd.com/read/29115397/detection-of-calprotectin-in-inflammatory-bowel-disease-fecal-and-serum-levels-and-immunohistochemical-localization
#11
Shuhei Fukunaga, Kotaro Kuwaki, Keiichi Mitsuyama, Hidetoshi Takedatsu, Shinichiro Yoshioka, Hiroshi Yamasaki, Ryosuke Yamauchi, Atsushi Mori, Tatsuyuki Kakuma, Osamu Tsuruta, Takuji Torimura
The aim of the present study was to quantify calprotectin levels using an enzyme-linked immunosorbent assay (ELISA) and a point-of-care test (POCT) in patients with inflammatory bowel disease. Overall, 113 patients with ulcerative colitis (UC; 51 men and 62 women) and 42 patients with Crohn's disease (CD; 29 men and 13 women), who were scheduled to undergo a colonoscopy, were prospectively enrolled and scored endoscopically and clinically. An additional 96 healthy, age-matched subjects served as the normal controls...
November 7, 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29112087/fecal-amino-acid-analysis-can-discriminate-de-novo-treatment-na%C3%A3-ve-pediatric-inflammatory-bowel-disease-from-controls
#12
Sofie Bosch, Eduard A Struys, Nora van Gaal, Abdellatif Bakkali, Erwin W Jansen, Kay Diederen, Marc A Benninga, Chris J Mulder, Nanne K H de Boer, Tim G J de Meij
OBJECTIVES: Endoscopy remains mandatory in the diagnostic work-up of inflammatory bowel disease (IBD), but is a costly and invasive procedure. Identification of novel, non-invasive, diagnostic biomarkers remains a priority. The aim of this study was to explore the potential of fecal amino acid composition as diagnostic biomarker for pediatric IBD. METHODS: In this case-control study, treatment-naïve, de novo pediatric IBD patients from two tertiary centers were included...
November 3, 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/29099941/formula-feeding-predisposes-neonatal-piglets-to-clostridium-difficile-gut-infection
#13
Lukasz Grzeskowiak, Beatriz Martínez-Vallespín, Temesgen H Dadi, Judith Radloff, Salah Amasheh, Femke-Anouska Heinsen, Andre Franke, Knut Reinert, Wilfried Vahjen, Jürgen Zentek, Robert Pieper
Spontaneous Clostridium difficile (CD) outbreaks occur in neonatal piglets but the predisposing factors are largely not known. To study the conditions for CD colonisation and infection development, neonatal piglets (n=48) were moved into isolators, fed bovine milk-based formula and infected with CD 078. Analyses included: clinical scoring; faecal CD, toxin B, calprotectin; post-mortem colon histopathology. Controls were non-infected suckling piglets. Faeces from suckling, formula-fed and formula-fed-CD-infected piglets were used for metagenomics...
November 1, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29097934/correlation-of-18f-fdg-pet-mre-metrics-with-inflammatory-biomarkers-in-patients-with-crohn-s-disease-a-pilot-study
#14
Liran Domachevsky, Haim Leibovitzh, Irit Avni-Biron, Lev Lichtenstein, Natalia Goldberg, Meital Nidam, David Groshar, Hanna Bernstine, Ofer Ben-Bassat
Background: To investigate the association between 18F-FDG (Fluorodeoxyglucose) PET (positron emission tomography)/MRE (magnetic resonance enterography) metrics with the inflammatory biomarkers fecal calprotectin and C-reactive protein (CRP) in patients with Crohn's disease (CD). Methods: This prospective pilot study was institutional review board (IRB) approved with informed consent obtained. Consecutive CD patients were referred to 18F-FDG PET/MRE. Patients in whom colonoscopy was performed and CRP and fecal calprotectin levels were measured were included...
2017: Contrast Media & Molecular Imaging
https://www.readbyqxmd.com/read/29096949/effect-of-tight-control-management-on-crohn-s-disease-calm-a-multicentre-randomised-controlled-phase-3-trial
#15
Jean-Frederic Colombel, Remo Panaccione, Peter Bossuyt, Milan Lukas, Filip Baert, Tomas Vaňásek, Ahmet Danalioglu, Gottfried Novacek, Alessandro Armuzzi, Xavier Hébuterne, Simon Travis, Silvio Danese, Walter Reinisch, William J Sandborn, Paul Rutgeerts, Daniel Hommes, Stefan Schreiber, Ezequiel Neimark, Bidan Huang, Qian Zhou, Paloma Mendez, Joel Petersson, Kori Wallace, Anne M Robinson, Roopal B Thakkar, Geert D'Haens
BACKGROUND: Biomarkers of intestinal inflammation, such as faecal calprotectin and C-reactive protein, have been recommended for monitoring patients with Crohn's disease, but whether their use in treatment decisions improves outcomes is unknown. We aimed to compare endoscopic and clinical outcomes in patients with moderate to severe Crohn's disease who were managed with a tight control algorithm, using clinical symptoms and biomarkers, versus patients managed with a clinical management algorithm...
October 30, 2017: Lancet
https://www.readbyqxmd.com/read/29089427/the-metallophore-staphylopine-enables-staphylococcus-aureus-to-compete-with-the-host-for-zinc-and-overcome-nutritional-immunity
#16
Kyle P Grim, Brian San Francisco, Jana N Radin, Erin B Brazel, Jessica L Kelliher, Paola K Párraga Solórzano, Philip C Kim, Christopher A McDevitt, Thomas E Kehl-Fie
During infection, the host sequesters essential nutrients, such as zinc, to combat invading microbes. Despite the ability of the immune effector protein calprotectin to bind zinc with subpicomolar affinity, Staphylococcus aureus is able to successfully compete with the host for zinc. However, the zinc importers expressed by S. aureus remain unknown. Our investigations have revealed that S. aureus possesses two importers, AdcABC and CntABCDF, which are induced in response to zinc limitation. While AdcABC is similar to known zinc importers in other bacteria, CntABCDF has not previously been associated with zinc acquisition...
October 31, 2017: MBio
https://www.readbyqxmd.com/read/29084074/clinical-and-symptom-scores-are-significantly-correlated-with-fecal-microbiota-features-in-patients-with-symptomatic-uncomplicated-diverticular-disease-a-pilot-study
#17
Charlotte L Kvasnovsky, Lex E X Leong, Jocelyn M Choo, Guy C J Abell, Savvas Papagrigoriadis, Kenneth D Bruce, Geraint B Rogers
BACKGROUND: There is growing consensus that symptomatic uncomplicated diverticular disease is a chronic inflammatory condition, and that alterations in the fecal microbiota may contribute to its pathogenesis. OBJECTIVE: The aim of this study was to relate the fecal microbiota composition in symptomatic uncomplicated diverticular disease to measures of inflammation, symptoms, and history of previous acute diverticulitis. PARTICIPANTS AND METHODS: Fecal microbiota composition in 28 individuals with symptomatic uncomplicated diverticular disease was characterized by 16S RNA gene amplicon sequencing...
October 27, 2017: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29077839/anti-tnf-re-induction-is-as-effective-simpler-and-cheaper-compared-with-dose-interval-shortening-for-secondary-loss-of-response-in-crohn-s-disease
#18
Ashish Srinivasan, Abhinav Vasudevan, Anne McFarlane, Miles P Sparrow, Peter R Gibson, Daniel van Langenberg
Background and Aims: The optimal duration of dose-intensified therapy following secondary loss of response (LOR) to anti-TNF therapy remains unclear. Anti-TNF re-induction involves a finite period of intensified therapy and may be a cost-effective means of re-capturing response. This study aimed to compare the efficacy, durability and cost of anti-TNF re-induction and dose interval shortening (DIS) for secondary LOR in Crohn's disease (CD). Methods: This was a retrospective observational study in CD patients who developed secondary LOR to maintenance anti-TNF therapy requiring subsequent re-induction and/or DIS...
October 25, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/29068000/%C3%AE-glucans-in-food-modify-colonic-microflora-by-inducing-antimicrobial-protein-calprotectin-in-a-dectin-1-induced-il-17f-dependent-manner
#19
T Kamiya, C Tang, M Kadoki, K Oshima, M Hattori, S Saijo, Y Adachi, N Ohno, Y Iwakura
Dectin-1 (gene symbol: Clec7a) is a receptor for β-glucans that play an important role for the host defense against fungi. Recently, we showed that Clec7a(-/-) mice are resistant against dextran sodium sulfate (DSS)-induced colitis because of regulatory T-cell population expansion in the colon. The regulatory T-cell expansion is caused by expansion of commensal Lactobacillus murinus whose growth is suppressed by an antimicrobial protein, calprotectin S100A8/A9. In this report, we showed that S100A8 was mainly produced by mouse colonic epithelial cells...
October 25, 2017: Mucosal Immunology
https://www.readbyqxmd.com/read/29065905/severe-intestinal-dysbiosis-is-prevalent-in-primary-sj%C3%A3-gren-s-syndrome-and-is-associated-with-systemic-disease-activity
#20
Thomas Mandl, Jan Marsal, Peter Olsson, Bodil Ohlsson, Kristofer Andréasson
BACKGROUND: Altered microbial composition of the intestine, commonly referred to as dysbiosis, has been associated with several autoimmune diseases including primary Sjögren's syndrome (pSS). The aims of the current study were to study the intestinal microbial balance in pSS and to identify clinical features associated with dysbiosis. METHODS: Forty-two consecutive pSS patients and 35 age-matched and sex-matched control subjects were included in the study in an open clinic setting...
October 24, 2017: Arthritis Research & Therapy
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