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S Goetze, A K Dumke, D Zillikens, U C Hipler, P Elsner
Anti-laminin γ1-pemphigoid (formerly known as anti-p200 pemphigoid) is a rare subepidermal autoimmunobullous disorder first described by Zillikens et al. in 1996 (1,2). Clinically, it mimics bullous pemphigoid, linear IgA dermatosis, dermatitis herpetiformis, pompholyx or the inflammatory variant of epidermolysis bullosa acquisita, respectively (1,3). The laminin γ1-chain has been identified as the major targeting antigen (1,4,5). Histologically, a subepidermal split is seen accompanied by neutrophils and eosinophils as well as linear deposits of IgG and/or C3 along the dermoepidermal junction in direct immunofluorescence microscopy (1)...
September 29, 2016: Journal of the European Academy of Dermatology and Venereology: JEADV
Aya Nishizawa
Dyshidrotic eczema, also known as dyshidrotic dermatitis or pompholyx, is characterized by pruritic, small tense vesicles mainly on the palmoplantar region and lateral and ventral surfaces of the fingers. While its etiology appears to be related to sweating, as dyshidrotic eczema often occurs in an individual with hyperhidrosis, and the spring allergy season, histologic examination shows an eczematous reaction around the sweat ducts which is not associated with abnormalities of the sweat ducts. More recently, the nomenclature of 'acute and recurrent vesicular hand dermatitis' has been proposed to reflect clinical features of dyshidrotic eczema...
2016: Current Problems in Dermatology
E Forbat, F R Ali, F Al-Niaimi
Botulinum neurotoxin (BoNT) is renowned for its inhibitory effects on the neuromuscular junction. The evidence for its use in cosmetic dermatology and in non-dermatological indications is well established. We have systemically analysed the evidence for the non-cosmetic dermatological uses of BoNT. This review presents the many small studies showing promising results for the use of BoNT in a multitude of dermatological diseases, including (but not limited to) hyperhidrosis, Darier's disease, Hailey-Hailey disease, pompholyx and hidradenitis suppurativa...
July 16, 2016: Journal of the European Academy of Dermatology and Venereology: JEADV
Hongcan Shi, Yusheng Shu, Weiping Shi, Shichun Lu, Chao Sun
The objective of this study is to investigate the feasibility and safety of single-port microthoracoscopic thoracic sympathicotomy for the treatment of palmar hyperhidrosis. Between January 2008 and March 2013, 56 patients (36 male, 20 female; mean age 25.6 years, age range 16-39 years) underwent single-port microthoracoscopic thoracic sympathicotomy for palmar hyperhidrosis. Nineteen patients (33.9 %) had moderate palmar hyperhidrosis that could thoroughly wet a handkerchief, and 37 (66.1 %) had severe palmar hyperhidrosis with sweat dripping from the palm...
August 2015: Indian Journal of Surgery
Dong In Keum, Hannah Hong, Sang-Hoon Lee, Sung Ku Ahn
No abstract text is available yet for this article.
August 2015: Annals of Dermatology
Jeewanjit Gill, Melanie Pratt
BACKGROUND: Pompholyx is an inflammatory vesiculobullous skin disease of the hands and feet belonging to the spectrum of eczema. OBJECTIVE: To report a severe case of pompholyx, its clinical presentation, and its management. METHODS: A medical chart review was conducted on a patient with this condition. RESULTS: The patient was patch tested according to the North American Contact Dermatitis Group (NACDG) Standard Screening Series, and results were negative...
September 2015: Journal of Cutaneous Medicine and Surgery
S Bhattarai, S Agrawal, A Rijal
Hand eczema (HE) is a common and distressing condition that is perplexing to the patient and the physician alike. To study the frequency and clinical features of hand eczema and to correlate the frequency of atopy and contact sensitization with different clinical features a total of 61 clinically diagnosed patient of Hand eczema were included within a period of one year. Patch test was done in 47 patients and graded accordingly. The frequency of hand eczema was 0.57%. Morphologically pompholyx was the most common type while aetiologically endogenous hand eczema was the commonest...
September 2014: Nepal Medical College Journal: NMCJ
D C Soler, X Bai, L Ortega, T Pethukova, S T Nedorost, D L Popkin, K D Cooper, T S McCormick
Pompholyx remains a chronic skin affliction without a compelling pathophysiological explanation. The disease is characterized by the sudden onset of vesicles exclusively in the palms and soles which generally resolves. However, the disease may progress and the vesicles may expand and fuse; with chronicity there is deep fissuring. Multiple therapeutic approaches are available, but the disease is often resistant to conventional treatments. Currently, oral alitretinoin is used for patients with resistant chronic disease; however, this therapy is only approved for use in the UK, Europe and Canada...
May 2015: Medical Hypotheses
Kayo Jin, Yasushi Matsuzaki, Ayumi Korekawa, Akiko Rokunohe, Takayuki Aizu, Chihiro Kinjyo, Hajime Nakano, Daisuke Sawamura
No abstract text is available yet for this article.
April 2015: European Journal of Dermatology: EJD
Varadraj V Pai, Pankaj Shukla, K N Naveen, Sharat Chandra Athanikar, U S Dinesh
No abstract text is available yet for this article.
November 2014: Indian Dermatology Online Journal
Hassan Ali Mohebbi, Shaban Mehrvarz, Shahram Manoochehry
BACKGROUND: Primary hyperhidrosis (P.H.H.) is characterized by excessive sweating in certain parts of body. It's estimated prevalence is 0%-6.1% in different populations. In Asian population its prevalence is around 3%. In 57% of cases, there is a positive family history. OBJECTIVES: To evaluate and compare the early and late satisfaction, outcomes and complications of thoracoscopic sympathectomy and sympathicotomy in the treatment of primary hyperhidrosis. MATERIALS AND METHODS: From April 2007 to January 2011, we prospectively treated 60 primary hyperhidrosis patients via thoracoscopic surgery...
2012: Trauma Monthly
D Y Kim, J Y Kim, T G Kim, J E Kwon, H Sohn, J Park, B J Lim, S H Oh
BACKGROUND: Both palmoplantar pustulosis (PPP) and pompholyx are clinically characterized by acute eruptions of vesicles or pustules on the palms or soles. OBJECTIVES: This study aims to compare the expression of certain inflammatory mediator genes and proteins between patients with PPP and pompholyx using skin tissue samples. METHODS: Skin biopsies obtained from lesional skin from patients with PPP (n = 7) and pompholyx (n = 5) were analysed by quantitative RT-PCR to measure the mRNA levels of nine genes, including IL-4, IL-8, IL-9, IL-17, IL-22, IFN-γ, CCL-20, granzyme and perforin...
December 2013: Journal of the European Academy of Dermatology and Venereology: JEADV
Jaime Pérez, Soledad Aspillaga, Alex Castro, Pedro Clavería, Rodrigo Sepúlveda
No abstract text is available yet for this article.
November 2014: International Journal of Dermatology
S Y Yoon, H S Park, J H Lee, S Cho
BACKGROUND: Palmoplantar pustulosis (PPP) is a chronic and intensely inflammatory skin disease with pustules, erythema and scaling localized to the palms and soles. Pompholyx is characterized by recurrent crops of vesicles on the lateral aspects of the fingers and the palms and soles. Because both PPP and pompholyx share similar clinical and histological features, it is difficult to differentiate between these two diseases even for dermatologists. OBJECTIVE: To compare the histological features of PPP and pompholyx and to analyse their clinical characteristics...
July 2013: Journal of the European Academy of Dermatology and Venereology: JEADV
Ana Maria Abreu-Velez, Frank J Pinto, Michael S Howard
CONTEXT: Pompholyx (called dyshidrosis by some) is one of the most common conditions and its immune response is presently poorly understood. CASE REPORT: We describe a 58 year old African American female with a clinical history of rheumatoid arthritis and type II diabetes who presented a chronic five-year, itchy vesicular/blistering rash involving her hands and feet. A lesional skin biopsy was taken for hematoxylin and eosin (H & E) analysis. In addition, a multicolor direct immunofluorescence (MDIF) and immunohistochemistry (IHC) studies were performed...
August 2009: North American Journal of Medical Sciences
Philip Vincent Charlton
No abstract text is available yet for this article.
2012: BMJ Case Reports
Antonella Tammaro, Alessandra Narcisi, Severino Persechino, Cristiano Caperchi, Anthony Gaspari
Nickel allergy can result in both cutaneous and systemic manifestations, and can range from mild to severe symptoms. A severe form of this allergy is the Systemic nickel allergy syndrome, clinically characterized by cutaneous manifestions (contact dermatitis, pompholyx, hand dermatitis dyshydrosis, urticaria) with chronic course and systemic symptoms (headache, asthenia, itching, and gastrointestinal disorders related to histopathological alterations of gastrointestinal mucosa, borderline with celiac disease)...
September 2011: Dermatitis
Varinder Singh, Meghna Sharma, Tarun Narang, Manas Madan
A 16-year-old young man presented with intensely itchy erythematous dermatitis on the body for 1 week and vesicular lesions on the palms and soles for 4 to 5 days. Lesions on the palms and soles were accompanied by severe burning and itching. The patient gave a history of sore throat and fever, 1 week prior to the onset of lesions. A general physical examination was normal, and cutaneous examination revealed multiple, well-defined erythematous scaly plaques with collaret scaling on the trunk and extremities (Figure 1)...
March 2012: Skinmed
Chun Kiat Lee, Tze Ping Loh, Soon Tee Wong, Hong Kai Lee, Pei Tee Huan, Lily-Lily Chiu, Evelyn Siew-Chuan Koay
A 62-year-old Chinese patient with recurrent pompholyx submitted his blood sample for pre-treatment thiopurine S-methyltransferase (TPMT) pharmacogenetic profiling, and it was found to harbour a novel single nucleotide polymorphism (SNP). The novel SNP, detected by mRNA sequencing, was a c.2T>C (g.11018T>C) transition in the start codon, causing a Met1Thr amino acid change. This finding was confirmed on a subsequent blood sample from the same patient by DNA sequencing. The patient was genotyped as TPMT*1/*29, sequentially named as such following the latest TPMT SNP (TPMT*1/*28) at the time of writing...
2012: Drug Metabolism and Pharmacokinetics
Sanjeev Handa, Inderjit Kaur, Tarun Gupta, Rashmi Jindal
BACKGROUND: Hand eczema is a common distressing condition aggravated by a number of endogenous and exogenous factors. Various morphological forms of hand eczema have been described, but categorization into one of them is not always possible. AIMS: To study the morphological patterns of hand eczema, relationship of atopy with hand eczema, and the implications of contact sensitization with respect to severity and diagnosis of hand eczema. METHODS: Hundred consecutive patients of hand eczema attending the contact dermatitis clinic of the institute were recruited over a two year period from 2004-05...
March 2012: Indian Journal of Dermatology, Venereology and Leprology
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