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Galectin-3

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https://www.readbyqxmd.com/read/29788922/galectin-3-activates-tlr4-nf-%C3%AE%C2%BAb-signaling-to-promote-lung-adenocarcinoma-cell-proliferation-through-activating-lncrna-neat1-expression
#1
Wu Zhou, Xing Chen, Qinghua Hu, Xuliang Chen, Yingji Chen, Lingjin Huang
BACKGROUND: Lung cancer remains the top contributor to cancer-related mortality worldwide. Long non-coding RNAs (lncRNAs) have been reported to participate in normal development and tumorigenesis. LncRNA nuclear enriched abundant transcript 1 (NEAT1) is highly expressed in lung cancer and promotes lung cancer cell proliferation and migration. However, the upstream regulatory mechanism still needs investigation. METHODS: In the present study, we investigated the upstream regulators and mechanisms of NEAT1 expression disorders...
May 22, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29769800/the-therapeutic-potential-of-blocking-galectin-3-expression-in-acute-myocardial-infarction-and-mitigating-inflammation-of-infarct-region-a-clinical-outcome-based-translational-study
#2
Wassim Mosleh, Milind R Chaudhari, Swati Sonkawade, Supriya Mahajan, Charl Khalil, Kevin Frodey, Tanvi Shah, Suraj Dahal, Roshan Karki, Rujuta Katkar, W Matthijs Blankesteijn, Brian Page, Saraswati Pokharel, Minhyung Kim, Umesh C Sharma
Introduction: Increased galectin-3 is associated with ischemic cardiomyopathy, although its role in early remodeling post-myocardial infarction (MI) has not been fully elucidated. There are no data demonstrating that blocking galectin-3 expression would have an impact on the heart and that its relationship to remodeling is not simply an epiphenomenon. The direct association between galectin-3 and myocardial inflammation, dysfunction, and adverse cardiovascular outcomes post-MI was examined using clinical and translational studies...
2018: Biomarker Insights
https://www.readbyqxmd.com/read/29769742/modified-citrus-pectin-inhibited-bladder-tumor-growth-through-downregulation-of-galectin-3
#3
Tian Fang, Dan-Dan Liu, He-Ming Ning, Dan Liu, Jing-Ya Sun, Xiao-Jing Huang, Yu Dong, Mei-Yu Geng, Shi-Feng Yun, Jun Yan, Rui-Min Huang
Modified citrus pectin (MCP) is a carbohydrate enriched complex, which has been implicated in cancer treatment and prevention. However, the effects of MCP on urinary bladder cancer (UBC) are unknown. In this study, MCP was first tested in T24 and J82 human UBC cells and showed the inhibition of cell viability by the sulforhodamine B (SRB) assay. The MCP-treated UBC cells exhibited G2 /M phase arrest with the decrease of Cyclin B1 and phosphorylated Cdc2. Caspase-3 was also activated, leading to the cleavage of Caspase-3 and PARP...
May 16, 2018: Acta Pharmacologica Sinica
https://www.readbyqxmd.com/read/29760188/depression-in-type-1-diabetes-was-associated-with-high-levels-of-circulating-galectin-3
#4
Eva O Melin, Jonatan Dereke, Maria Thunander, Magnus Hillman
OBJECTIVE: Neuroinflammatory responses are implicated in depression. The aim was to explore whether depression in patients with type 1 diabetes (T1D) was associated with high circulating galectin-3, controlling for metabolic variables, s-creatinine, life style factors, medication, and cardiovascular complications. DESIGN: Cross-sectional. METHODS: Participants were T1D patients (n=283, 56% men, age 18-59 years, diabetes duration ≥1 year)...
May 14, 2018: Endocrine Connections
https://www.readbyqxmd.com/read/29756004/galectin-3-and-incident-cognitive-impairment-in-regards-a-cohort-of-blacks-and-whites
#5
Anand Venkatraman, Peter Callas, Leslie A McClure, Fred Unverzagt, Garima Arora, Virginia Howard, Virginia G Wadley, Mary Cushman, Pankaj Arora
Introduction: The relationship between serum galectin-3 and incident cognitive impairment was analyzed in the Reasons for Geographic and Racial Differences in Stroke study. Methods: Baseline galectin-3 was measured in 455 cases of incident cognitive impairment and 546 controls. Galectin-3 was divided into quartiles based on the weighted distribution in the control group, and the first quartile was the referent. Results: There was an increasing odds of cognitive impairment across quartiles of galectin-3 (odds ratios, 1...
2018: Alzheimer's & Dementia: Translational Research & Clinical Interventions
https://www.readbyqxmd.com/read/29753686/pharmacological-inhibition-of-the-mitochondrial-nadph-oxidase-4-pkc%C3%AE-gal-3-pathway-reduces-left-ventricular-fibrosis-following-myocardial-infarction
#6
Maria Del Carmen Asensio-Lopez, Antonio Lax Perez, Maria Josefa Fernandez Del Palacio, Yassine Sassi, Roger J Hajjar, Domingo A Pascual-Figal
Although the initial reparative fibrosis after myocardial infarction (MI) is crucial for preventing rupture of the ventricular wall, an exaggerated fibrotic response and reactive fibrosis outside the injured area are detrimental. Although metformin prevents adverse cardiac remodeling, as well as provides glycemic control, the underlying mechanisms remain poorly documented. This study describes the effect of mitochondrial NADPH oxidase 4 (mitoNox) and protein kinase C-alpha (PKCα) on the cardiac fibrosis and galectin 3 (Gal-3) expression...
April 23, 2018: Translational Research: the Journal of Laboratory and Clinical Medicine
https://www.readbyqxmd.com/read/29748377/galectin-3-modulates-the-polarized-surface-delivery-of-%C3%AE-1-integrin-in-epithelial-cells
#7
Ellena Hönig, Karina Ringer, Jenny Dewes, Tobias von Mach, Natalia Kamm, Geri Kreitzer, Ralf Jacob
Epithelial cells require a precise intracellular transport and sorting machinery in order to establish and maintain their polarized architecture. This machinery includes beta-galactoside binding galectins for glycoprotein targeting to the apical membrane. Galectin-3 sorts cargo destined for the apical plasma membrane into vesicular carriers. After delivery of cargo to the apical milieu, galectin-3 recycles back into sorting organelles. We analyzed the role of galectin-3 in the polarized distribution of β1-integrin in MDCK cells...
May 10, 2018: Journal of Cell Science
https://www.readbyqxmd.com/read/29743357/the-antiviral-activity-of-the-cellular-glycoprotein-lgals3bp-90k-is-species-specific
#8
Veronika Lodermeyer, George Ssebyatika, Vânia Passos, Aparna Ponnurangam, Angelina Malassa, Ellen Ewald, Christina M Stürzel, Frank Kirchhoff, Margalida Rotger, Christine S Falk, Amalio Telenti, Thomas Krey, Christine Goffinet
Cellular antiviral proteins interfere with distinct steps of replication cycles of viruses. The galectin 3 binding protein (LGALS3BP, also known as 90K) was previously shown to lower the infectivity of nascent HIV-1 virions when expressed in virus-producing cells. This antiviral effect was accompanied by impaired gp160Env processing and reduced viral incorporation of mature Env glycoproteins. Here, we examined the ability of 90K orthologs from primate species to reduce particle infectivity of distinct lentiviruses...
May 9, 2018: Journal of Virology
https://www.readbyqxmd.com/read/29737871/circulating-biomarkers-of-hypertrophy-and-fibrosis-in-patients-with-hypertrophic-cardiomyopathy-assessed-by-cardiac-magnetic-resonance
#9
Monika Gawor, Mateusz Śpiewak, Agata Kubik, Aleksandra Wróbel, Anna Lutyńska, Magdalena Marczak, Jacek Grzybowski
PURPOSE: Myocardial fibrosis in hypertrophic cardiomyopathy (HCM) is associated with worse clinical outcomes. The availability of circulating biomarkers of myocardial fibrosis and hypertrophy would be helpful in clinical practice. METHODS: Levels of biomarkers: soluble ST2 (sST2), galectin-3, growth differentiation factor-15 (GDF-15), NT-proBNP, and high-sensitivity cardiac troponin T (hs-cTnT) were measured in 60 patients with HCM. All patients underwent cardiac magnetic resonance imaging to calculate parameters of hypertrophy and fibrosis...
May 8, 2018: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/29730688/the-value-of-global-longitudinal-strain-and-galectin-3-for-predicting-cardiovascular-events-in-patients-with-severe-aortic-stenosis
#10
Lucia Agoston-Coldea, Kunal Bheecarry, Cristian Petra, Lelia Strambu, Camelia Ober, Radu Revnic, Silvia Lupu, Teodora Mocan, Daniela Fodor
AIMS: Left ventricular global longitudinal strain (GLS) was shown to predict outcomes after valve replacement in patients with aortic stenosis (AS). In the current study, we aimed to test the combined use of GLS and a marker of fibrosis - Galectin-3 - for predicting major cardiovascular adverse events (MACEs) in patients with severe AS. MATERIALS AND METHODS: We conducted a prospective study on 42 patients with severe AS and 42 volunteers. Patient evaluation included biochemistry tests, electrocardiogram, 24-hour Holter monitoring, the 6-minute walk test, and echocardiography...
May 2, 2018: Medical Ultrasonography
https://www.readbyqxmd.com/read/29729689/immunoexpression-of-progesterone-receptor-epithelial-growth-factor-receptor-and-galectin-3-in-uterine-smooth-muscle-tumors
#11
Mervat M Soltan, Abdelkader Mohammed Albasry, Maha K Eldosouky, Hanan S Abdelhamid
Uterine smooth muscle tumors constitute a spectrum of neoplasms. Diagnosis of leiomyomas (LMs) is usually straight forwards; however, atypical leiomyomas (ALMs) and smooth muscle tumors of uncertain malignant potential (STUMPs) have overlapping features and need to be distinguished from leiomyosarcoma. To evaluate progesterone receptor (PR), epithelial growth factor receptor (EGF-R), and galectin-3 expression in LMs, ALMs, STUMPs, and leiomyosarcomas and to assess their possible role in differentiating those tumors...
April 30, 2018: Cellular and Molecular Biology
https://www.readbyqxmd.com/read/29723491/qsox1-a-novel-actor-of-cardiac-protection-upon-acute-stress-in-mice
#12
Anais Caillard, Malha Sadoune, Arthur Cescau, Mehdi Meddour, Marine Gandon, Evelyne Polidano, Claude Delcayre, Kelly Da Silva, Philippe Manivet, Ana-Maria Gomez, Alain Cohen-Solal, Nicolas Vodovar, Zhenlin Li, Alexandre Mebazaa, Jane-Lise Samuel
QSOX1, a sulfhydryl oxidase, was shown to be upregulated in the heart upon acute heart failure (AHF). The aim of the study was to unravel QSOX1 roles during AHF. We generated and characterized mice with QSOX1 gene deletion. The QSOX1-/- mice were viable but adult male exhibited a silent dilated cardiomyopathy. The QSOX1-/- hearts were characterized by low protein SERCA2a levels associated with a calcium homeostasis alteration, high levels of the endoplasmic reticulum (ER) chaperone proteins Grp78/Bip, and of the ER apoptosis sensor CHOP, indicating a chronic unfolded protein response (UPR)...
April 30, 2018: Journal of Molecular and Cellular Cardiology
https://www.readbyqxmd.com/read/29719535/lactose-induces-phenotypic-and-functional-changes-of-neutrophils-and-macrophages-to-alleviate-acute-pancreatitis-in-mice
#13
Li-Long Pan, Yuan-Yuan Deng, Ruxing Wang, Chengfei Wu, Jiahong Li, Wenying Niu, Qin Yang, Madhav Bhatia, Gudmundur H Gudmundsson, Birgitta Agerberth, Julien Diana, Jia Sun
Acute pancreatitis (AP) is one common clinical acute abdominal disease, for which specific pharmacological or nutritional therapies remain elusive. Lactose, a macronutrient and an inducer of host innate immune responses, possesses immune modulatory functions. The current study aimed to investigate potential modulatory effects of lactose and the interplay between the nutrient and pancreatic immunity during experimentally induced AP in mice. We found that either prophylactic or therapeutic treatment of lactose time-dependently reduced the severity of AP, as evidenced by reduced pancreatic edema, serum amylase levels, and pancreatic myeloperoxidase activities, as well as by histological examination of pancreatic damage...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29716523/mice-lacking-galectin-3-lgals3-function-have-decreased-home-cage-movement
#14
Tammy R Chaudoin, Stephen J Bonasera
BACKGROUND: Galectins are a large family of proteins evolved to recognize specific carbohydrate moieties. Given the importance of pattern recognition processes for multiple biological tasks, including CNS development and immune recognition, we examined the home cage behavioral phenotype of mice lacking galectin-3 (Lgals3) function. Using a sophisticated monitoring apparatus capable of examining feeding, drinking, and movement at millisecond temporal and 0.5 cm spatial resolutions, we observed daily behavioral patterns from 10 wildtype male C57BL/6J and 10 Lgals3 constitutive knockout (Lgals3-/- ; both cohorts aged 2-3 months) mice over 17 consecutive days...
May 2, 2018: BMC Neuroscience
https://www.readbyqxmd.com/read/29704198/extracellular-galectin-3-induces-accelerated-oligodendroglial-differentiation-through-changes-in-signaling-pathways-and-cytoskeleton-dynamics
#15
Laura Thomas, Laura Andrea Pasquini
Galectin-3 (Gal-3) is a chimeric protein structurally composed of unusual tandem repeats of proline and short glycine-rich segments fused onto a carbohydrate recognition domain. Our studies have previously demonstrated that Gal-3 drives oligodendrocyte (OLG) differentiation to control myelin integrity and function. The cytoskeleton plays a key role in OLG maturation: the initial stage of OLG process extension requires dynamic actin filament assembly, while subsequent myelin wrapping coincides with the upregulation of actin disassembly proteins which are dependent on myelin basic protein (MPB) expression...
April 27, 2018: Molecular Neurobiology
https://www.readbyqxmd.com/read/29700556/diagnostic-value-of-novel-biomarkers-for-heart-failure-a-meta-analysis
#16
Z Huang, J Zhong, Y Ling, Y Zhang, W Lin, L Tang, J Liu, S Li
BACKGROUND: The present meta-analysis examined the diagnostic value of novel biomarkers for heart failure (HF), including copeptin, galectin-3, hs-cTnT, MR-proANP, MR-proADM, and ST2. METHODS: English (EMBASE, Cochrane, and PubMed) and Chinese (Wanfang data, CNKI, SinoMed) databases were searched to identify suitable studies that were published before 1 December 2016. Data were extracted using standard forms. Pooled diagnostic statistics were calculated using DerSimonian-Laird random-effects models...
April 26, 2018: Herz
https://www.readbyqxmd.com/read/29692765/a-carbohydrate-moiety-of-secreted-stage-specific-glycoprotein-4-participates-in-host-cell-invasion-by-trypanosoma-cruzi-extracellular-amastigotes
#17
Pilar T V Florentino, Fernando Real, Cristina M Orikaza, Julia P C da Cunha, Francisca N L Vitorino, Esteban M Cordero, Tiago J P Sobreira, Renato A Mortara
Trypanosoma cruzi is the etiologic agent of Chagas' disease. It is known that amastigotes derived from trypomastigotes in the extracellular milieu are infective in vitro and in vivo . Extracellular amastigotes (EAs) have a stage-specific surface antigen called Ssp-4, a GPI-anchored glycoprotein that is secreted by the parasites. By immunoprecipitation with the Ssp-4-specific monoclonal antibodies (mAb) 2C2 and 1D9, we isolated the glycoprotein from EAs. By mass spectrometry, we identified the core protein of Ssp-4 and evaluated mRNA expression and the presence of Ssp-4 carbohydrate epitopes recognized by mAb1D9...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29692588/value-of-cytokeratin-19-hector-battifora-mesothelial-1-and-galectin-3-immunostaining-in-the-diagnosis-of-thyroid-neoplasms
#18
Rajasekhar Sanuvada, Rukmangadha Nandyala, Amit Kumar Chowhan, Phaneendra Bobbidi, Mutheeswariah Yootla, Narendra Hulikal, Alok Sachan
BACKGROUND: Diagnosis of types and aggressiveness of thyroid cancers is difficult. The "gold standard" in diagnosis is using routine hematoxylin and eosin staining. Several markers have been investigated for differentiating them among which cytokeratin-19 (CK-19), Hector Battifora mesothelial cell (HBME-1), and galectin-3 are found to be most commonly used. Most studies have evaluated the single expression of markers in various thyroid lesions. AIMS AND OBJECTIVES: To know the value of immunohistochemical expression of CK-19, HBME-1, and galectin-3 in diagnosing thyroid neoplasms...
April 2018: Journal of Laboratory Physicians
https://www.readbyqxmd.com/read/29692335/study-of-the-plasma-proteome-of-atlantic-cod-gadus-morhua-changes-due-to-crude-oil-exposure
#19
Karianne S Enerstvedt, Magne O Sydnes, Daniela M Pampanin
Oil contamination is an environmental issue of great concern and the necessity for background studies and monitoring programs to continuously evaluate the levels of oil pollution is required. In this study, Atlantic cod (Gadus morhua) were exposed to dispersed crude oil for 1 and 4 weeks to simulate environmental contamination. Fractionated plasma samples were then analysed by tandem mass spectrometry. In total, 717 proteins were identified and 10 new protein biomarker candidates were found. The significant proteome changes were related to the immune response by alterations in the levels of specific immunoglobulins, alpha-2-macroglobulin and galectin-3-binding proteins...
April 17, 2018: Marine Environmental Research
https://www.readbyqxmd.com/read/29691398/galectin-3-deficiency-drives-lupus-like-disease-by-promoting-spontaneous-germinal-centers-formation-via-ifn-%C3%AE
#20
Cristian Gabriel Beccaria, María Carolina Amezcua Vesely, Facundo Fiocca Vernengo, Ricardo Carlos Gehrau, María Cecilia Ramello, Jimena Tosello Boari, Melisa Gorosito Serrán, Juan Mucci, Eliane Piaggio, Oscar Campetella, Eva Virginia Acosta Rodríguez, Carolina Lucía Montes, Adriana Gruppi
Germinal centers (GC) are important sites for high-affinity and long-lived antibody induction. Tight regulation of GC responses is critical for maintaining self-tolerance. Here, we show that Galectin-3 (Gal-3) is involved in GC development. Compared with WT mice, Gal-3 KO mice have more GC B cells and T follicular helper cells, increased percentages of antibody-secreting cells and higher concentrations of immunoglobulins and IFN-γ in serum, and develop a lupus-like disease. IFN-γ blockade in Gal-3 KO mice reduces spontaneous GC formation, class-switch recombination, autoantibody production and renal pathology, demonstrating that IFN-γ overproduction sustains autoimmunity...
April 24, 2018: Nature Communications
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