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https://www.readbyqxmd.com/read/28636718/trends-and-outcomes-of-off-label-use-of-transcatheter-aortic-valve-replacement-insights-from-the-ncdr-sts-acc-tvt-registry
#1
Ravi S Hira, Sreekanth Vemulapalli, Zhuokai Li, James M McCabe, John S Rumsfeld, Samir R Kapadia, Mahboob Alam, Hani Jneid, Creighton Don, Mark Reisman, Salim S Virani, Neal S Kleiman
Importance: Transcatheter aortic valve replacement (TAVR) was approved by the US Food and Drug Administration for severe aortic stenosis in patients who cannot undergo surgery and for patients at high operative risk. Use of TAVR for off-label indications has not been previously reported. Objective: To evaluate patterns and adverse outcomes of off-label use of TAVR in US clinical practice. Design, Setting and Participants: Patients receiving commercially funded TAVR in the United States are included in the Transcatheter Valve Therapy Registry...
June 21, 2017: JAMA Cardiology
https://www.readbyqxmd.com/read/28631145/biaxial-mechanical-properties-of-bovine-jugular-venous-valve-leaflet-tissues
#2
Hsiao-Ying Shadow Huang, Jiaqi Lu
Venous valve incompetence has been implicated in diseases ranging from chronic venous insufficiency (CVI) to intracranial venous hypertension. However, while the mechanical properties of venous valve leaflet tissues are central to CVI biomechanics and mechanobiology, neither stress-strain curves nor tangent moduli have been reported. Here, equibiaxial tensile mechanical tests were conducted to assess the tangent modulus, strength and anisotropy of venous valve leaflet tissues from bovine jugular veins. Valvular tissues were stretched to 60% strain in both the circumferential and radial directions, and leaflet tissue stress-strain curves were generated for proximal and distal valves (i...
June 19, 2017: Biomechanics and Modeling in Mechanobiology
https://www.readbyqxmd.com/read/28631106/transthoracic-3d-echocardiographic-left-heart-chamber-quantification-in-patients-with-bicuspid-aortic-valve-disease
#3
Allard T van den Hoven, Jackie S Mc-Ghie, Raluca G Chelu, Anthonie L Duijnhouwer, Vivan J M Baggen, Adriaan Coenen, Wim B Vletter, Marcel L Dijkshoorn, Annemien E van den Bosch, Jolien W Roos-Hesselink
Integration of volumetric heart chamber quantification by 3D echocardiography into clinical practice has been hampered by several factors which a new fully automated algorithm (Left Heart Model, (LHM)) may help overcome. This study therefore aims to evaluate the feasibility and accuracy of the LHM software in quantifying left atrial and left ventricular volumes and left ventricular ejection fraction in a cohort of patients with a bicuspid aortic valve. Patients with a bicuspid aortic valve were prospectively included...
June 19, 2017: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/28629660/characterization-and-risk-factors-for-aortic-dilatation-in-pediatric-patients-with-bicuspid-aortic-valve
#4
Anna Sabaté-Rotés, Laura Sabidó Sanchez, Ferran Gran Ipiña, Dimpna Albert Brotons, Raúl F Abella, Ferran Rosés Noguer
INTRODUCTION AND OBJECTIVES: Dilatation of the ascending aorta associated with bicuspid aortic valve is a major cause of morbidity and mortality in adults. The main objective was to recognize the aortic involvement in children, its characteristics and risk factors. METHODS: Aortic measures of all pediatric patients with bicuspid aortic valve followed in a tertiary pediatric hospital between 1997 and 2015 were retrospectively taken. Patients with syndromes associated with aortic dilatation were excluded (n=17)...
June 16, 2017: Medicina Clínica
https://www.readbyqxmd.com/read/28625366/feasibility-of-transcatheter-aortic-valve-replacement-in-low-risk-patients-with-symptomatic-severe-aortic-stenosis-rationale-and-design-of-the-low-risk-tavr-lrt-study
#5
Toby Rogers, Rebecca Torguson, Roshni Bastian, Paul Corso, Ron Waksman
BACKGROUND: Safety and effectiveness of transcatheter aortic valve replacement (TAVR) in low-risk patients with symptomatic severe aortic stenosis have not yet been established. HYPOTHESIS: Transcatheter aortic valve replacement is feasible in patients with symptomatic severe aortic stenosis and low risk for surgical aortic valve replacement. DESIGN: The LRT study is the first US Food and Drug Administration-approved Investigational Device Exemption prospective multicenter feasibility trial of TAVR in low-risk patients...
July 2017: American Heart Journal
https://www.readbyqxmd.com/read/28623496/association-between-flow-skewness-and-aortic-dilatation-in-patients-with-aortic-stenosis
#6
Hojin Ha, Hyun Jung Koo, June Goo Lee, Guk Bae Kim, Jihoon Kweon, Sang Joon Lee, Joon Won Kang, Tae Hwan Lim, Dae Hee Kim, Jong Min Song, Duk Hyun Kang, Jae Kwan Song, Young Hak Kim, Namkug Kim, Dong Hyun Yang
We investigated association between hemodynamic characteristics and aortic dilatation in patients with severe aortic stenosis (AS). Eighty patients with severe AS (mean age, 67.2 ± 12.5 years) who underwent multi-detector computed tomography and phase-contrast magnetic resonance imaging at the ascending aorta were retrospectively analyzed. Patients with an ascending aorta diameter >4 cm had a significantly higher forward flow rate at systole (28.5 ± 6.0 vs. 36.2 ± 8.6 L min, P < 0...
June 16, 2017: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/28622047/repositionable-and-retrievable-lotus-valve-system-for-the-treatment-of-bicuspid-aortic-stenosis-is-it-time-to-treat-all-valves
#7
Roberto Nerla, Fausto Castriota, Antonio Micari, Estevao de Campos Martins, Alberto Cremonesi
INTRODUCTION: For a long time, a bicuspid valve has been considered a contraindication to transcatheter aortic valve implantation (TAVI) due to worse procedural results. Currently available technologies are changing the scenario, with initial experiences reporting much better results with second-generation devices. AREAS COVERED: This review will analyze the risk and potential pitfalls of TAVI on bicuspid valves and will try ascertain how the use of a new-generation fully repositionable device, the Lotus Valve System (LVS), could improve procedural and clinical results in bicuspid anatomies...
June 16, 2017: Expert Review of Medical Devices
https://www.readbyqxmd.com/read/28620320/abnormal-haemodynamic-flow-patterns-in-bicuspid-pulmonary-valve-disease
#8
Malenka M Bissell, Margaret Loudon, Stefan Neubauer, Saul G Myerson
Abnormal flow patterns in the aortas of those with bicuspid aortic valves (BAVs) are increasingly recognized as important in the pathogenesis of aortic dilatation but pulmonary flow patterns in bicuspid pulmonary valves have not been studied. Bicuspid pulmonary valve disease is rare and a small numbers of case reports describe concomitant pulmonary artery dilation similar to the dilation of the ascending aorta, which is often seen in BAVs disease. We examined three cases of bicuspid pulmonary valve disease, 10 healthy volunteers and 10 patients with BAV disease but a tricuspid pulmonary valve...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28617301/acute-aortic-regurgitation-in-a-bicuspid-aortic-valve-due-to-the-rupture-of-an-anomalous-cord
#9
Hiroyuki Watanabe, Mai Shimbo, Kenji Iino, Hiroshi Yamamoto, Hiroshi Ito
No abstract text is available yet for this article.
June 2017: Anatolian Journal of Cardiology
https://www.readbyqxmd.com/read/28616354/comparing-american-european-and-asian-practice-guidelines-for-aortic-diseases
#10
Jose Rozado, Maria Martin, Isaac Pascual, Daniel Hernandez-Vaquero, Cesar Moris
The aortic disease comprises a group of different pathologies of high prevalence, seriousness and ever changing by the medical and surgical investigations. Therefore cardiovascular scientific societies in USA, Europe and Asia have created Task Force on practice guidelines (PG) to develop, update and revise PG for aortic diseases. These documents issue recommendations on the diagnosis and management of different aortic diseases. The three societies agree on the recommendations about diagnostic tests and on the value of computed tomography and magnetic resonance as the main tools for the diagnosis and follow-up of aortic disease...
May 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28616342/bicuspid-aortic-valve-syndrome-a-multidisciplinary-approach-for-a-complex-entity
#11
REVIEW
María Martín, Rebeca Lorca, José Rozado, Rubén Alvarez-Cabo, Juan Calvo, Isaac Pascual, Helena Cigarrán, Isabel Rodríguez, César Morís
Bicuspid aortic valve (BAV) or bicuspid aortopathy is the most common congenital heart disease. It can be clinically silent and it is often identified as an incidental finding in otherwise healthy, asymptomatic patients. However, it can be dysfunctioning at birth, even requiring neonatal intervention, or, in time, lead to aortic stenosis, aortic insufficiency, and endocarditis, and also be associated with aortic aneurysm and aortic dissection. Given its prevalence and significant complications, it is estimated that BAV is responsible for more deaths and morbidity than the combined effects of all the other congenital heart defects...
May 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28611119/turbulent-kinetic-energy-assessed-by-multipoint-4-dimensional-flow-magnetic-resonance-imaging-provides-additional-information-relative-to-echocardiography-for-the-determination-of-aortic-stenosis-severity
#12
Christian Binter, Alexander Gotschy, Simon H Sündermann, Michelle Frank, Felix C Tanner, Thomas F Lüscher, Robert Manka, Sebastian Kozerke
BACKGROUND: Turbulent kinetic energy (TKE), assessed by 4-dimensional (4D) flow magnetic resonance imaging, is a measure of energy loss in disturbed flow as it occurs, for instance, in aortic stenosis (AS). This work investigates the additional information provided by quantifying TKE for the assessment of AS severity in comparison to clinical echocardiographic measures. METHODS AND RESULTS: Fifty-one patients with AS (67±15 years, 20 female) and 10 healthy age-matched controls (69±5 years, 5 female) were prospectively enrolled to undergo multipoint 4D flow magnetic resonance imaging...
June 2017: Circulation. Cardiovascular Imaging
https://www.readbyqxmd.com/read/28610884/outcomes-for-low-risk-surgical-aortic-valve-replacement-a-benchmark-for-aortic-valve-technology
#13
Lily E Johnston, Emily A Downs, Robert B Hawkins, Mohammed A Quader, Alan M Speir, Jeffrey B Rich, Ravi K Ghanta, Leora T Yarboro, Gorav Ailawadi
BACKGROUND: Two large, randomized trials are underway evaluating transcatheter aortic valve replacement (AVR) against conventional surgical AVR. We analyzed contemporary, real-world outcomes of surgical AVR in low-risk patients to provide a practical benchmark of outcomes and cost for evaluating current and future transapical AVR technology. METHODS: From 2010 to 2015, 2,505 isolated AVR operations were performed for severe aortic stenosis at 18 statewide cardiac institutions...
June 11, 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/28610440/circumflex-coronary-artery-originating-from-the-right-pulmonary-artery-in-adult
#14
Ahmet Daylan, Serkan Ertugay, Anıl Ziya Apaydın, Emrah Oğuz
Anomalous origin of the circumflex coronary artery from the right pulmonary artery is rare, and symptoms are related to the collateralization and amount of myocardium that it supplies. A 50-year-old woman with severe bicuspid aortic valve stenosis had the diagnosis of anomalous origin of the circumflex coronary artery from the right pulmonary artery before valve replacement. Ligation and division of the circumflex coronary artery was performed. Myocardial ischemia was not observed. The patient was discharged after an uneventful recovery...
January 1, 2017: Asian Cardiovascular & Thoracic Annals
https://www.readbyqxmd.com/read/28610230/-i-lampetra-i-i-soljani-i-a-new-brook-lamprey-from-the-southern-adriatic-sea-basin-petromyzontiformes-petromyzontidae
#15
Pero Tutman, Jörg Freyhof, Jakov Dulčić, Branko Glamuzina, Matthias Geiger
Lampetra soljani, new species, is described from the lower Neretva River in the Adriatic Sea basin. Previously it was identified as L. zanandreai. Based on morphological similarity and mitochondrial genetic data, it is related to L. lanceolata and L. ninae from the Black Sea basin. Lampetra soljani is distinguished from all other species of Lampetra by having a marmorate flank pattern in live, fully grown ammocoetes, and in some adults (vs. plain colour pattern). Lampetra soljani is distinguished from other Lampetra species by having three velar tentacles, 54-57 trunk myomeres between the last branchial opening and the anus, no posterial teeth and a bicuspid middle endolateral tooth...
June 7, 2017: Zootaxa
https://www.readbyqxmd.com/read/28599977/fate-of-remnant-sinuses-of-valsalva-in-patients-with-bicuspid-and-trileaflet-valves-undergoing-aortic-valve-ascending-aorta-and-aortic-arch-replacement
#16
Rita Karianna Milewski, Andreas Habertheuer, Joseph E Bavaria, Mary Siki, Wilson Y Szeto, Eric Krause, Varun Korutla, Nimesh D Desai, Prashanth Vallabhajosyula
OBJECTIVE: In patients presenting with aortic valvulopathy with concomitant ascending aortic aneurysm, surgical management of the sinus of Valsalva segment remains undefined, especially for moderately dilated aortic roots. In patients with this pathology undergoing aortic valve replacement with supracoronary ascending aorta replacement, we assessed the fate of the remnant preserved sinus of Valsalva segment stratified by aortic valve morphology and pathology. METHODS: From 2002 to 2015, 428 patients underwent elective aortic valve replacement with supracoronary ascending aorta replacement...
April 28, 2017: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/28596303/prevalence-and-predictors-of-intracranial-aneurysms-in-patients-with-bicuspid-aortic-valve
#17
Alexander C Egbe, Ratnasari Padang, Robert D Brown, Arooj R Khan, Sushil A Luis, John Huston, Emmanuel Akintoye, Heidi M Connolly
OBJECTIVE: To determine the prevalence and outcomes of intracranial aneurysm (IA) in patients with bicuspid aortic valve (BAV) METHODS: Retrospective review of patients with BAV who underwent brain MR angiography at the Mayo Clinic from 1994 to 2013. RESULTS: There were 678 patients included in this study-mean age 57±13 years, men 480 (71%), mean follow-up 10±3 years (5913 patient-years). Coarctation of aorta (COA) was present in 154 (23%) patients.There were 59 IAs identified in 52 of 678 patients (7...
June 8, 2017: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/28593686/hypostomus-sertanejo-siluriformes-loricariidae-new-armoured-catfish-species-from-north-eastern-brazil
#18
C H Zawadzki, T P A Ramos, M Sabaj
A re-evaluation of the armoured catfish species of Hypostomus in the Rio Jaguaribe, north-eastern Brazil, was prompted by the discovery of specimens with pale spots on a dark background collected from that basin c. 1936 and deposited at the Academy of Natural Sciences of Philadelphia. Recent field collections in the Rio Jarguaribe basin confirmed the presence of the pale-spotted specimens and its distinctiveness as a new species. Hypostomus sertanejo n. sp. is diagnosed from other species of Hypostomus by having fins and dermal-plated regions of head and body with pale spots or vermiculations on darker background, teeth slender, asymmetrically bicuspid and numerous (34-75) on dentary and premaxilla, depressed dorsal-fin spine not reaching adipose spine, unbranched pectoral-fin spine longer than unbranched pelvic-fin ray, seven branched dorsal-fin rays and one (rarely two) predorsal plate(s) bordering supraoccipital...
June 7, 2017: Journal of Fish Biology
https://www.readbyqxmd.com/read/28592596/indexed-aortic-area-in-bicuspid-valve-disease-an-important-step-toward-a-more-personalized-approach-to-risk-prediction-and-clinical-decision-making
#19
EDITORIAL
Stephanie L Sellers, Darra T Murphy, Jonathon A Leipsic
No abstract text is available yet for this article.
June 2017: Circulation. Cardiovascular Imaging
https://www.readbyqxmd.com/read/28592593/aortic-cross-sectional-area-height-ratio-and-outcomes-in-patients-with-bicuspid-aortic-valve-and-a-dilated-ascending-aorta
#20
Ahmad Masri, Vidyasagar Kalahasti, Lars G Svensson, Alaa Alashi, Paul Schoenhagen, Eric E Roselli, Douglas R Johnston, L Leonardo Rodriguez, Brian P Griffin, Milind Y Desai
BACKGROUND: In patients with bicuspid aortic valve and dilated proximal ascending aorta, we sought to assess (1) factors associated with increased longer-term cardiovascular mortality and (2) incremental prognostic use of indexing aortic root to patient height. METHODS AND RESULTS: We studied 969 consecutive bicuspid aortic valve patients (50±13 years; 87% men) with proximal aorta ≥4 cm, who also had a gated contrast-enhanced thoracic computed tomography or magnetic resonance angiography...
June 2017: Circulation. Cardiovascular Imaging
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