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Choroidal biopsy

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https://www.readbyqxmd.com/read/28871936/xanthoma-like-skin-changes-in-an-elderly-woman-with-a-normal-lipid-profile
#1
Piotr Nockowski, Zdzisław Woźniak, Adam Reich, Joanna Maj
Dear Editor, An 83-year-old woman developed yellow-brownish infiltrates, nodules, and tumors mimicking xanthomas, mostly involving the periorbital and chest area within three months (Figure 1). She had no abnormalities in serum cholesterol or triglycerides levels. A detailed laboratory analysis revealed the presence of mild monoclonal gammopathy with a presence of immunoglobulin G (IgG) kappa light chains; however, according to hematologist consultation, it did not require medical intervention. Imaging assessment and ultrasound examination did not show any specific involvement of internal organs...
July 2017: Acta Dermatovenerologica Croatica: ADC
https://www.readbyqxmd.com/read/28868288/uveal-melanoma-with-histopathologic-intratumoral-heterogeneity-associated-with-gene-expression-profile-discordance
#2
Audra K Miller, Matthew J Benage, David J Wilson, Alison H Skalet
PURPOSE: To report a case of intratumoral gene expression profile discordance in a malignant uveal melanoma, associated with intratumoral heterogeneity based upon histopathologic features. METHODS: The clinical history, fundus findings, imaging and histopathologic features, and DecisionDx-UM gene expression profile results (Castle Biosciences, Inc., Phoenix, AZ, USA) of the tumor were reviewed. RESULTS: A trans-retinal fine-needle aspiration biopsy was performed for a thin, pigmented choroidal tumor in a 33-year-old man...
July 2017: Ocular Oncology and Pathology
https://www.readbyqxmd.com/read/28868277/extramedullary-relapse-of-acute-myelogenous-leukemia-presenting-as-a-large-serous-retinal-detachment
#3
Wesley Green, P Kumar Rao, George J Harocopos
BACKGROUND/AIMS: To describe the rare presentation of a large, unilateral, serous retinal detachment as an extramedullary manifestation of acute myelogenous leukemia (AML) recurrence without bone marrow or central nervous system involvement after more than 1 year of follow-up. METHODS: Case report. RESULTS: A teenage patient with AML, previously treated with multiple courses of systemic chemotherapy, radiation, and bone marrow transplant, presented with acute vision loss...
July 2017: Ocular Oncology and Pathology
https://www.readbyqxmd.com/read/28868276/uveal-melanoma-regression-after-brachytherapy-relationship-with-chromosome-3-monosomy-status
#4
Sachin M Salvi, Hassan A Aziz, Suhail Dar, Nakul Singh, Brandy Hayden-Loreck, Arun D Singh
AIM: The objective was to evaluate the relationship between the regression rate of ciliary body melanoma and choroidal melanoma after brachytherapy and chromosome 3 monosomy status. METHODS: We conducted a prospective and consecutive case series of patients who underwent biopsy and brachytherapy for ciliary/choroidal melanoma. Tumor biopsy performed at the time of radiation plaque placement was analyzed with fluorescence in situ hybridization to determine the percentage of tumor cells with chromosome 3 monosomy...
July 2017: Ocular Oncology and Pathology
https://www.readbyqxmd.com/read/28835091/gastric-adenocarcinoma-with-systemic-metastasis-involving-the-intraocular-choroid-and-duodenum
#5
Soon Young Kim, Kee-Taek Jang, Jun Haeng Lee
Gastric cancer with double metastasis to the orbit and duodenum is extremely rare. We report the case of a patient with gastric adenocarcinoma who presented with synchronous orbital and duodenal metastases at the time of initial diagnosis. A 60-year-old man presented with a 1-month history of visual disorder and pain in his right eye. He underwent ophthalmological examinations. The biopsy results suggested intraocular metastatic carcinoma. We conducted a systemic evaluation to identify primary malignancy. Finally, a diagnosis of advanced gastric adenocarcinoma with multi-organ metastasis was made...
May 22, 2017: Clinical Endoscopy
https://www.readbyqxmd.com/read/28820170/paradoxical-worsening-of-a-case-of-tb-subretinal-abscess-with-serpiginous-like-choroiditis-following-the-initiation-of-antitubercular-therapy
#6
Sudha K Ganesh, B Sowkath Ali
A 37-year-old immunocompetent male patient presented with the blurring of vision, both eyes for the past1 year. Fundus examination revealed bilateral multiple subretinal abscesses with areas of healed serpiginous-like choroiditis. Laboratory investigations showed positive tuberculin skin test, positive QuantiFERON TB-Gold Test, and high resolution computed tomography chest showed enlarged mediastinal lymph nodes. The aqueous sample revealed polymerase chain reaction (PCR) positive for Mycobacterium tuberculosis (MTB) (MPB64 genome)...
August 2017: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/28810043/amalric-triangular-syndrome-associated-with-outer-nuclear-layer-infarction
#7
Sean T Garrity, Eric J Holz, David Sarraf
An 85-year-old man presented with temporal headache and bilateral paracentral scotomas. Clinical examination, laboratory testing, and temporal artery biopsy confirmed the diagnosis of giant cell arteritis. Fluorescein angiography illustrated Amalric triangular choroidal infarction of the left eye. Spectral-domain optical coherence tomography of the left eye demonstrated outer nuclear layer abnormalities adjacent to the choroidal infarct. [Ophthalmic Surg Lasers Imaging Retina. 2017;48:668-670.].
August 1, 2017: Ophthalmic Surgery, Lasers & Imaging Retina
https://www.readbyqxmd.com/read/28743137/-surgical-methods-in-the-treatment-of-uveal-melanoma
#8
Georgios Blatsios, Gertrud Haas, Claus Zehetner, Nikolaos E Bechrakis
Significant advancements have been made in the last decades in the treatment of uveal melanoma. Radiation therapy can achieve, depending on the method, local tumour control in up to 98% of cases. Surgical modalities have been implemented in the ocular therapy for uveal melanoma either to treat/prevent radiation complications, such as so-called toxic tumour syndrome, or to primarily treat the tumour with or without adjunctive radiotherapy. These include endoresection and transscleral resection for melanomas of the choroid/ciliary body or irido-trabeculo-cyclectomy for melanomas of the iris-ciliary body...
July 2017: Klinische Monatsblätter Für Augenheilkunde
https://www.readbyqxmd.com/read/28739193/intraocular-metastasis-comparison-of-clinical-presentation-with-a-known-and-unknown-primary-tumour
#9
R Ramoa, M A Saornil, C García-Alvarez, P Diezhandino, P Alonso-Martínez, E García-Lagarto, M F Muñoz-Moreno, F Lopez-Lara
OBJECTIVE: The purpose of the present study is to review the frequency of intraocular metastases as first presentation of systemic disease, and to identify clinical and tumour characteristics. METHODS: Retrospective study of consecutive cases diagnosed of intraocular metástasis at a referral intraocular tumours unit between 1993 and 2014. General, epidemiological and ophthalmological characteristics were recorded. RESULTS: A total of 21 patients, with a mean age 62...
July 21, 2017: Archivos de la Sociedad Española de Oftalmología
https://www.readbyqxmd.com/read/28690979/presentation-treatment-and-prognosis-of-secondary-melanoma-within-the-orbit
#10
Anna M Rose, Sophie Cowen, Channa N Jayasena, David H Verity, Geoffrey E Rose
BACKGROUND: Ocular melanoma is a rare but often deadly malignancy that arises in the uvea, conjunctiva, or orbit. Uveal melanoma is the most common type, with conjunctival melanoma being the second most frequently observed. Melanoma accounts for 5-10% of metastatic or secondary orbital malignancies, but only a minute proportion of primary orbital neoplasia. The aim of this study was to characterize the clinical presentation, treatment, and prognosis in patients presenting with melanoma metastatic to, or secondary within, the orbit...
2017: Frontiers in Oncology
https://www.readbyqxmd.com/read/28678217/choroid-plexus-tuberculoma-diagnosis-management-and-role-of-endoscopy
#11
Nishanth Sadashiva, Bevinahalli N Nandeesh, Dhaval Shukla, Bhagavatula I Devi
Ventricular involvement in central nervous system tuberculosis can be in the form of tuberculous ependymitis, intraventricular tuberculoma, intraventricular tuberculous abscess, choroid plexitis and choroid plexus tuberculoma. Only a few cases of choroid plexus tuberculomas have been described and even more rare is the description of the role of endoscopy in management of intraventricular tuberculomas. We report a 33-year-old patient while on treatment for tubercular meningitis who developed a left side choroid plexus lesion with loculated temporal horn...
July 2017: Neurosciences: the Official Journal of the Pan Arab Union of Neurological Sciences
https://www.readbyqxmd.com/read/28643722/endogenous-endophthalmitis-caused-by-cryptococcus-neoformans-var-gattii-mimicking-choroidal-tumor-from-positron-emission-tomography-computed-tomography-to-histopathology
#12
Chun-Ju Lin, Wen-Lu Chen, Jane-Ming Lin, Peng-Tai Tien, Yi-Yu Tsai
A 60-year-old immunocompetent female with pneumonia history about 10 years ago suffered from blurred vision overall survival for 3 weeks. Common cold with headache and unintentional body weight loss was also noted recently. Choroidal detachment simulating choroidal tumor was observed in the temporal quadrant. The 18F-fluoro-2-deoxyglucose (FDG) positron-emission tomography/computed tomography (CT) scan showed focal, mild to moderate FDG uptake in the left lateral orbit, and an enhanced lesion was seen on the recent CT scan...
June 2017: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/28598265/robot-assisted-endoscopic-third-ventriculostomy-institutional-experience-in-9-patients
#13
Reid Hoshide, Mark Calayag, Hal Meltzer, Michael L Levy, David Gonda
OBJECTIVE The endoscopic third ventriculostomy (ETV) is an established and effective treatment for obstructive hydrocephalus. In its most common application, surgeons plan their entry point and the endoscope trajectory for the procedure based on anatomical landmarks, then control the endoscope freehand. Recent studies report an incidence of neural injuries as high as 16.6% of all ETVs performed in North America. The authors have introduced the ROSA system to their ETV procedure to stereotactically optimize endoscope trajectories, to reduce risk of traction on neural structures by the endoscope, and to provide a stable mechanical holder of the endoscope...
August 2017: Journal of Neurosurgery. Pediatrics
https://www.readbyqxmd.com/read/28596284/prognostic-biopsy-of-choroidal-melanoma-an-optimised-surgical-and-laboratory-approach
#14
Martina Angi, Helen Kalirai, Azzam Taktak, Rumana Hussain, Carl Groenewald, Bertil E Damato, Heinrich Heimann, Sarah E Coupland
BACKGROUND: Accurate survival prognostication for patients with uveal melanoma (UM) enables effective patient counselling and permits personalised systemic surveillance for the early detection of metastases and, in high-risk patients, enrolment in any trials of systemic adjuvant therapy. The aim of this work is to determine the success of prognostic UM tumour biopsy using an improved surgical approach and optimised sample handling workflow. METHODS: Patients with UM treated by primary radiotherapy between 2011 and 2013 and who underwent a prognostic biopsy with cytology, multiplex ligation-dependent probe amplification and/or microsatellite analysis were included...
August 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28538392/maculopapular-rash-after-intravitreal-injection-of-an-antivascular-endothelial-growth-factor-aflibercept-for-treating-age-related-macular-degeneration-a-case-report
#15
Norihiro Nagai, Mari Ibuki, Hajime Shinoda, Kaori Kameyama, Kazuo Tsubota, Yoko Ozawa
RATIONALE: Aflibercept, an anti-vascular endothelial growth factor (VEGF) drug, is used for treatment of colon cancer as well as retinal diseases, including wet age-related macular degeneration (AMD). It is injected into the vitreous cavity of eyes for treatment of AMD. Although vascular suppression-including cardiovascular events-and local infection related to the injection procedure are well-known potential adverse events, pathological immune responses after intravitreal aflibercept (IVA) injection have not been described...
May 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28499052/outcomes-of-27-gauge-vitrectomy-assisted-choroidal-and-subretinal-biopsy
#16
Dilraj S Grewal, Thomas J Cummings, Prithvi Mruthyunjaya
BACKGROUND AND OBJECTIVE: To report the initial experience of 27-gauge vitrectomy-assisted choroidal and subretinal biopsy PATIENTS AND METHODS: Retrospective, interventional case series. Eighteen eyes of 18 patients undergoing 27-gauge vitrectomy-assisted choroidal (n = 16) or subretinal biopsy (n = 2). Clinical and lesion characteristics, cytopathology, histology, gene expression profiling (GEP), visual acuity (VA), complications including vitreous hemorrhage (VH), development of rhegmatogenous retinal detachment (RD), and need for additional surgeries were analyzed...
May 1, 2017: Ophthalmic Surgery, Lasers & Imaging Retina
https://www.readbyqxmd.com/read/28496372/choroidal-extranodal-marginal-zone-lymphoma-diagnosed-by-full-thickness-retinochoroidal-biopsy-case-report-and-review-of-the-literature
#17
Ali Dirani, Guy Allaire, Sonia Callejo, Marie Lyne Belair, Katarzyna Biernacki, Christine Corriveau, Karim Hammamji
The case of an 89-year-old man who was referred for a painless decrease of vision in his right eye (RE) is reported. Fundus examination of the RE showed an elevated amelanotic lesion located in the posterior pole with an adjacent focal round pigmented lesion. There was also a more peripheral amelanotic lesion extending from 6 to 9 o'clock clockwise inferotemporally. Uveitis workup and imaging studies of brain and orbits were normal. A retinochoroidal biopsy was done and showed the presence of choroidal extranodal marginal zone lymphoma...
2017: International Medical Case Reports Journal
https://www.readbyqxmd.com/read/28495150/personalized-prognosis-of-uveal-melanoma-based-on-cytogenetic-profile-in-1059-patients-over-an-8-year-period-the-2017-harry-s-gradle-lecture
#18
Carol L Shields, Emil Anthony T Say, Murat Hasanreisoglu, Jarin Saktanasate, Brendan M Lawson, Jeffrey E Landy, Anjali U Badami, Meera D Sivalingam, Alexander J Hauschild, Robert J House, Zachary E Daitch, Arman Mashayekhi, Jerry A Shields, Arupa Ganguly
PURPOSE: To determine the personalized rate of uveal melanoma-related metastasis on the basis of individual tumor cytogenetic profile. DESIGN: Retrospective case series. PARTICIPANTS: A total of 1059 patients with uveal melanoma. METHODS: Fine-needle aspiration biopsy (FNAB) for DNA amplification and whole genome array-based assay were performed for analysis of chromosomes 3, 6, and 8. MAIN OUTCOME MEASURES: Melanoma-related metastasis...
May 7, 2017: Ophthalmology
https://www.readbyqxmd.com/read/28486310/vitrectomy-assisted-biopsy-for-molecular-prognostication-of-choroidal-melanoma-2-mm-or-less-in-thickness-with-a-27-gauge-cutter
#19
Aaron Nagiel, Colin A McCannel, Christian Moreno, Tara A McCannel
PURPOSE: Fine-needle aspiration biopsy of small choroidal melanomas 2 mm or less in thickness may be associated with a low biopsy yield. This report describes our center's experience using the 27-gauge vitreous cutter to perform tumor sampling in these small melanomas. METHODS: This was a retrospective analysis of all patients who underwent a 27-gauge vitreous cutter biopsy for molecular prognostication at the time of iodine-125 plaque placement for local treatment of choroidal melanoma ≤2...
July 2017: Retina
https://www.readbyqxmd.com/read/28461017/vitrectomy-and-vitrector-port-needle-biopsy-of-choroidal-melanoma-for-gene-expression-profile-testing-immediately-before-brachytherapy
#20
Deepthi M Reddy, Lauren B Mason, John O Mason, Jason N Crosson, Jacob J Yunker
PURPOSE: Transvitreal and transscleral needle biopsy can result in complications including vitreous hemorrhage and retinal detachment. This study evaluated a technique using 25-gauge vitrectomy as an adjunct to needle biopsy immediately before brachytherapy to minimize these complications and preserve good visual acuity. DESIGN: Retrospective, observational case series. PARTICIPANTS: Fifty-seven consecutive eyes of 57 patients with treatment-naïve medium choroidal melanomas without extraocular extension from July 2012 through September 2015...
September 2017: Ophthalmology
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