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Choroidal biopsy

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https://www.readbyqxmd.com/read/29785997/endoillumination-chandelier-and-wide-angle-viewing-assisted-fine-needle-aspiration-biopsy-of-intraocular-mass-lesions
#1
Pradeep Venkatesh, Seema Kashyap, Shreyas Temkar, Varun Gogia, Gaurav Garg, Rahul Kumar Bafna
Fine-needle aspiration biopsy (FNAB) of intraocular mass lesions is an important intervention in the presence of diagnostic difficulty. FNAB of intraocular mass lesions is also likely to become more commonly recommended for prognostication of tumors such as choroidal melanoma. The most commonly described approach for tumor localization and visualization during FNAB is transillumination and indirect ophthalmoscopic viewing. Herein, we report endoillumination (chandelier) and wide-angle viewing assisted, microscope-based approach for FNAB in two patients using two port minimally invasive vitreoretinal surgical approach...
June 2018: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/29780945/treatment-challenges-in-an-atypical-presentation-of-tubulointerstitial-nephritis-and-uveitis-tinu
#2
Sonny Caplash, Sapna Gangaputra, Shilpa Kodati, Shamir Tuchman, Hemalatha Srinivasalu, H Nida Sen
Purpose: To describe an atypical presentation of Tubulointerstitial Nephritis and Uveitis (TINU), with challenges in treatment course. Observations: A 12-year-old Hispanic female presented to the National Eye Institute's Uveitis clinic with bilateral blurred vision, red eyes and photophobia, not responsive to topical steroids. On exam, she had bilateral severe panuveitis with areas of subretinal fluid. During her evaluation, she was noted to have elevated serum creatinine...
June 2018: American Journal of Ophthalmology Case Reports
https://www.readbyqxmd.com/read/29772919/erythema-nodosum-as-the-initial-presentation-of-nivolumab-induced-sarcoidosis-like-reaction
#3
Alexandre Laroche, Evelyn Alarcon Chinchilla, Emilie Bourgeault, Marc-André Doré
BACKGROUND: We report a case of nivolumab-related sarcoidosis-like syndrome that initially presented with erythema nodosum. Sarcoidosis development has been described in single and combination immunotherapy. CASE PRESENTATION: A 68-year-old white woman with metastatic ocular amelanotic choroid melanoma was treated with nivolumab. The patient developed histologically confirmed erythema nodosum lesions and pulmonary granuloma sarcoidosis. Nivolumab was discontinued and the patient started ipilimumab therapy...
May 1, 2018: Journal of Cutaneous Medicine and Surgery
https://www.readbyqxmd.com/read/29768356/late-distant-recurrence-of-breast-carcinoma-and-metastasis-to-the-main-bronchus-and-choroid-a-case-report
#4
Zhijie Luo, Qin Cai, Yuanyuan Zhao, Xiaochuan Wang, Siying Fu, Linzhu Zhai
RATIONALE: Metastases of breast carcinoma to the main bronchus and choroid are rare, but have been reported in relevant literature. Late distant recurrence of breast carcinoma after more than 20 years is extremely rare. Herein, we report a 57-year-old woman with late distant recurrence and metastasis to the main bronchus and choroid almost 28 years after surgery. PATIENT CONCERNS: At the age of 29, the patient underwent chemotherapy and endocrine treatment after a right side mastectomy to remove breast carcinoma...
May 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29755268/cytogenetic-results-of-choroidal-nevus-growth-into-melanoma-in-55-consecutive-cases
#5
Carol L Shields, Maria Pefkianaki, Arman Mashayekhi, Jerry A Shields, Arupa Ganguly
Purpose: To investigate the cytogenetic results of choroidal nevus with photographically-documented transformation into choroidal melanoma. Methods: Retrospective analysis of 55 consecutive patients who underwent fine needle aspiration biopsy (FNAB) for DNA isolation and whole genome array based assay for chromosomes 3, 6, and 8 analysis prior to plaque radiotherapy. Tumors with abnormalities in chromosomes 3 and 8 were considered high-risk for metastasis. Results: At diagnosis of choroidal nevus the mean patient age was 57 years (median 57, range 10-83 years)...
January 2018: Saudi Journal of Ophthalmology: Official Journal of the Saudi Ophthalmological Society
https://www.readbyqxmd.com/read/29746787/diagnostic-challenge-with-nocardia-subretinal-abscess-a-case-report-from-tuberculosis-endemic-region
#6
Parthopratim Dutta Majumder, Madhura Mukherjee, Lily Therese, Lingam Gopal, Jyotirmay Biswas
PURPOSE: To describe a case of Nocardia subretinal abscess, which posed a diagnostic challenge due to the presence of mycobacterial genome in sample obtained from fine needle aspiration biopsy (FNAB). METHODS: A retrospective chart review. RESULTS: A 25-year-old male presented with sudden, painless onset diminution of vision of left eye and found to have placoid patch of choroiditis just temporal to the macula in right eye and showed vitritis, subretinal abscess with exudative retinal detachment and vitreous hemorrhage in left eye...
May 10, 2018: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/29739345/atypical-central-retinal-artery-occlusion-as-the-first-presentation-of-poems-syndrome-a-case-report
#7
Panitha Jindahra, Charungthai Dejthevaporn, Pimjai Niparuck, Jariya Waisayarat, Piyaphon Cheecharoen, Thanatporn Threetong, Purit Petpiroon, Tharikarn Sujirakul, Anuchit Poonyathalang, Kavin Vanikieti
BACKGROUND: POEMS syndrome is a plasma cell disorder, which clinically manifests from paraneoplastic syndrome: polyneuropathy, organomegaly, endocrinopathy, monoclonal plasma cell disorder, and skin changes. The most common ocular manifestation is optic disc swelling, whereas other ocular manifestations; cystoid macular edema, serous macular detachment, venous sinus thrombosis, infiltrative orbitopathy, uveitis, neovascularization of the disc, peripapillary choroidal neovascularization and optic disc drusen, had also been reported...
May 8, 2018: BMC Neurology
https://www.readbyqxmd.com/read/29701516/clinical-findings-and-outcomes-for-dogs-with-uveodermatologic-syndrome
#8
Mitzi K Zarfoss, Charlotte A Tusler, Philip H Kass, Keith Montgomery, Christine C Lim, Freya Mowat, Sara M Thomasy
OBJECTIVE To evaluate signalment, clinical signs, treatment, and factors affecting visual prognosis in dogs with uveodermatologic syndrome (UDS). DESIGN Retrospective case series and nested cohort study. ANIMALS 50 dogs (37 Akitas and 13 non-Akitas) with UDS evaluated at 4 ophthalmology practices. PROCEDURES Data were collected from the medical records regarding signalment, clinical signs, biopsy results, medications, adverse effects, vision and glaucoma status at initial and subsequent examinations, and duration of follow-up...
May 15, 2018: Journal of the American Veterinary Medical Association
https://www.readbyqxmd.com/read/29687085/orbital-melanocytoma-when-a-tumor-becomes-a-relieving-surprise
#9
Haytham E Nasr, Mohamed A Nouh, Rania A Ahmed, Abdelrahman M Elhusseiny
Purpose: Melanocytomas are rare pigmented tumors that arise form melanocytes and have been reported in the central nervous system. Orbital melanocytomas "also known as blue nevus" are rarely reported. The occurrence of choroidal melanoma and orbital melanocytomas has never been described. Observations: This is a case of orbital melanocytoma in a 34 year old female who presented with left proptosis and ecchymosis. She has the right eye enucleated to treat a large choroidal melanoma, 6 years earlier...
June 2018: American Journal of Ophthalmology Case Reports
https://www.readbyqxmd.com/read/29663723/intraocular-metastasis-of-medullary-thyroid-carcinoma-investigated-by-transscleral-fine-needle-aspiration-a-case-report-and-review-of-the-literature
#10
Małgorzata Gajdzis, Nathalie Cassoux, Maria Lesnik, Caroline Hoffmann, Nathalie Badois, Paweł Gajdzis, Jerzy Klijanienko
Medullary thyroid carcinoma occurs in a sporadic setting and may also be inherited in an autosomal dominant fashion, which is related with germline mutations of the RET gene. Metastases are often present at the time of a diagnosis-most frequently within the cervical lymph nodes, followed by the liver, lungs, and bones. Intraocular metastases are extremely rare. We present a case of choroidal metastasis as a first presentation of disease progression in a patient with Multiple Endocrine Neoplasia type 2A syndrome (MEN2A) who had undergone thyroidectomy 33 years earlier for medullary thyroid carcinoma...
April 16, 2018: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/29617945/intracranial-neoplasms-in-the-first-year-of-life-results-of-a-third-cohort-of-patients-from-a-single-institution
#11
Sebastian M Toescu, Gregory James, Kim Phipps, Owase Jeelani, Dominic Thompson, Richard Hayward, Kristian Aquilina
BACKGROUND: Brain tumors in the first year of life are rare and their management remains challenging. OBJECTIVE: To report on the contemporary management of brain tumors in infants with reference to previous series from our institution. METHODS: Retrospective cohort study design. Electronic/paper case note review of all brain tumors diagnosed at our institution in children aged <1 yr since the publication of our previous series. RESULTS: Ninety-eight patients were seen...
April 3, 2018: Neurosurgery
https://www.readbyqxmd.com/read/29596552/yield-techniques-and-complications-of-transvitreal-and-transscleral-biopsies-in-small-uveal-melanoma
#12
Ryan Sangwoo Kim, Patricia Chevez-Barrios, Mukul Divatia, Maria Eugenia Bretana, Bin Teh, Amy Claire Schefler
Importance: Intraoperative adequacy check of biopsy samples can lead to a higher biopsy yield rate, and subsequent genomic analysis can provide patients with valuable prognostic information. Objectives: To examine the yield rates for transscleral and transvitreal fine-needle aspiration biopsies of small uveal melanoma less than 3.6 mm in apical height and to discuss techniques that would maximize yield rates and minimize complications. Design, Setting, and Participants: A retrospective, consecutive observational case series was conducted from January 29, 2013, to May 23, 2017, at Retina Consultants of Houston and Houston Methodist Hospital among 44 patients with uveal melanoma of the ciliary body or choroid...
March 29, 2018: JAMA Ophthalmology
https://www.readbyqxmd.com/read/29503956/multifocal-choroiditis-as-the-first-sign-of-systemic-sarcoidosis-associated-with-pembrolizumab
#13
Qu-Knafo Lise, Auregan-Giocanti Audrey
Purpose: To report a case of bilateral panuveitis with multifocal choroiditis associated with a systemic sarcoidosis unmasked by pembrolizumab. Case report: A 68-years old woman with a history of metastatic melanoma treated by pembrolizumab consulted for bilateral blurred vision. The ophthalmologic examination revealed a bilateral anterior uveitis with cells in the anterior chamber and granulomatous keratic precipitates, vitreous cells and multifocal choroiditis confirmed by indocyanine green angiography...
April 2017: American Journal of Ophthalmology Case Reports
https://www.readbyqxmd.com/read/29439995/primary-photodynamic-therapy-with-verteporfin-for-pigmented-posterior-pole-ct1a-choroidal-melanoma-a-3-year-retrospective-analysis
#14
Ido Didi Fabian, Andrew W Stacey, Lamis Al Harby, Amit K Arora, Mandeep S Sagoo, Victoria M L Cohen
AIMS: To investigate the outcomes of primary photodynamic therapy (PDT) for pigmented posterior pole cT1a choroidal melanoma. METHODS: Retrospective interventional consecutive case series of 26 patients (26 eyes) with pigmented posterior pole cT1a choroidal melanoma, who were treated with 3 sessions of PDT and followed-up thereafter. RESULTS: Included were 11 males and 15 females that presented at a median age of 66 years (mean: 64) with transformed naevi (n=11) or suspicious lesions (n=15) with ≥3 risk factors for growth, with lipofuscin in all...
February 13, 2018: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/29380793/quantitative-polymerase-chain-reaction-analysis-of-serpiginous-choroiditis-with-biopsy-proven-testicular-tuberculosis
#15
Abhinav Dhami, Ranju Kharel Sitaula, Jyotirmay Biswas
We report a case of a 47-year-old male patient presenting with diminution of vision in the left eye. The left eye fundus showed yellowish lesions with indistinct geographical margin extending over the posterior pole just abutting the macula, suggestive of diffuse choroiditis. The patient gave a history of testicular swelling for the past 2 years. Aqueous tap for polymerase chain reaction analysis was positive for IS6110 mycobacterial tuberculosis (TB) genome, and a biopsy of testicular sac was suggestive of tubercular epididymitis...
February 2018: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/29280938/choroidal-tumor-biopsy-a-review-of-the-current-state-and-a-glance-into-future-techniques
#16
Avni P Finn, Miguel A Materin, Prithvi Mruthyunjaya
PURPOSE: To review the indications for and the methods of obtaining biopsies in eyes with uveal melanoma. In addition, this review provides recommendations for avoiding biopsy-related complications and discusses the future directions of biopsy techniques for uveal melanoma. METHODS: This review is based on a presentation by the authors (PM and MM) at the 2017 Duke Advanced Vitreoretinal Surgery Course and an extensive literature review using PubMed. RESULTS: Transscleral and transvitreal fine-needle aspiration biopsy, and transvitreal vitrectomy-assisted biopsy techniques are described...
December 26, 2017: Retina
https://www.readbyqxmd.com/read/29243035/systemic-lupus-erythematosus-and-ocular-involvement-an-overview
#17
REVIEW
Rosanna Dammacco
Systemic lupus erythematosus (SLE) is a multisystem autoimmune disease of undefined etiology and with remarkably heterogeneous clinical features. Virtually any organ system can be affected, including the eye. SLE-related eye involvement can be diagnosed in approximately one-third of the patients and is usually indicative of disease activity. An early diagnosis and the adoption of suitable therapeutic measures are necessary to prevent sight-threatening consequences, especially in patients with juvenile SLE. Periocular lesions, such as eyelid involvement and orbital inflammation, are relatively rare and, in case of orbital masses, may require a biopsy control...
December 14, 2017: Clinical and Experimental Medicine
https://www.readbyqxmd.com/read/29155757/dissection-of-human-retina-and-rpe-choroid-for-proteomic-analysis
#18
Thiago Cabral, Marcus A Toral, Gabriel Velez, James E DiCarlo, Anuradha M Gore, MaryAnn Mahajan, Stephen H Tsang, Alexander G Bassuk, Vinit B Mahajan
The human retina is composed of the sensory neuroretina and the underlying retinal pigmented epithelium (RPE), which is firmly complexed to the vascular choroid layer. Different regions of the retina are anatomically and molecularly distinct, facilitating unique functions and demonstrating differential susceptibility to disease. Proteomic analysis of each of these regions and layers can provide vital insights into the molecular process of many diseases, including Age-Related Macular Degeneration (AMD), diabetes mellitus, and glaucoma...
November 12, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29134136/creating-a-full-thickness-choroidal-incision-an-ex-vivo-analysis-of-human-and-porcine-tissue-contraction-dynamics
#19
Stephen A LoBue, Norihiro Yamada, Moon Jeong Choi, Timothy W Olsen
Purpose: We hypothesized that the elastic nature of the choroid leads to tissue contraction following a full-thickness, sharp incision. Furthermore, we sought to quantify, measure, and compare tissue contraction in ex vivo porcine globes and human globes of various ages using predetermined variables. Method: A full-thickness, ex vivo choroidal incision was performed in either pig ( n = 97) or human ( n = 30) specimens. Variables included trephine diameter (1.5, 2...
November 2017: Translational Vision Science & Technology
https://www.readbyqxmd.com/read/29118486/choroidal-melanoma-a-short-review-with-an-indian-perspective
#20
REVIEW
Bikramjit P Pal, Saili Garge, Vikas Khetan
Choroidal melanoma (CM), the most common intraocular tumor in adults, is still a rarity in Asia. Having a high propensity for metastasis with a poor survival, recognizing it early is essential. Although it has typical clinical features, there are instances of simulating lesions. Fine-needle aspiration biopsy can be a valuable tool not only to confirm our clinical suspicion but also aid in prognosticating it. From days of histopathological prognostic markers, we are moving on to genetic markers which are reliably providing insights, helping us in providing a better care for our patients...
September 2017: Oman Journal of Ophthalmology
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