Read by QxMD icon Read

Choroidal biopsy

Aruna Nambirajan, Mehar C Sharma, Madhu Rajeshwari, Aanchal Kakkar, Vaishali Suri, Chitra Sarkar
Ependymomas are gliomas that recapitulate normal ependymal cells. The epithelial membrane antigen (EMA) shows "dot-like" and "ring-like" staining patterns, highlighting "microlumens" or intracytoplasmic rosettes, a pathognomonic ultrastructural feature. NHERF1/EBP50, an adaptor protein localized at the apical plasma membrane of human epithelia, has been found to localize to these microlumens. We aimed to analyze the staining patterns of EMA and EBP50 in ependymomas and other tumors, and thereby compare their diagnostic utility...
October 7, 2016: Applied Immunohistochemistry & Molecular Morphology: AIMM
Swathi Kaliki, Suzanne K Freitag, James Chodosh
PURPOSE: To describe clinical presentation and histopathological features of a nodulo-ulcerative variant of ocular surface squamous neoplasia (OSSN). METHODS: Retrospective study. RESULTS: Six patients were identified with a nodulo-ulcerative variant of OSSN. Mean age at presentation was 56 years. One patient was immunosuppressed because of human immunodeficiency virus infection. The initial misdiagnosis was necrotizing scleritis/sclerokeratitis (n = 4), intraepithelial neoplasia (n = 1), and chalazion (n = 1)...
October 5, 2016: Cornea
Maria Teresa Mandara, Luca Motta, Pietro Calò
In cats, lymphoma (lymphosarcoma) is the most common neoplasm affecting the spinal cord and the second most common intracranial tumour. Although lymphoma commonly develops in the spinal cord as a part of a multicentric process, a primary form may occur. Lymphoma can exhibit a wide range of morphological patterns, including intraparenchymal brain mass, lymphomatosis cerebri, intravascular lymphoma, lymphomatous choroiditis and meningitis, extradural, intradural-extramedullary or intramedullary lymphoma in the spinal cord, or neurolymphomatosis in the peripheral nerves...
October 2016: Veterinary Journal
Dilraj S Grewal, Paramjit K Bhullar, Neel D Pasricha, Oscar M Carrasco-Zevallos, Christian Viehland, Brenton Keller, Liango Shen, Joseph A Izatt, Anthony N Kuo, Cynthia A Toth, Prithvi Mruthyunjaya
No abstract text is available yet for this article.
September 26, 2016: Retina
Arnaud Payerols, Eric Frouin, Aurélie Schiffmann, Nicolas Menjot de Champfleur, Danielle Canioni, Olivia Chandesris, Valérie Costes, Max Villain, Frédéric Mura
PURPOSE: Mastocytosis is characterized by clonal mast cell proliferation with accumulation within various organs and uncontrolled activation with excessive mast cell mediator release. Ocular manifestations have rarely been published. We describe a 63-year-old man with bilateral exophthalmos that led to the diagnosis of systemic mastocytosis. CASE REPORT: A patient presented with bilateral eyelid edema with exophthalmos associated with binocular diplopia. Ophthalmologic examination showed bilateral axial, symmetrical, and painless exophthalmos with eyelid edema, and limitation in elevation of the right eye...
August 24, 2016: Optometry and Vision Science: Official Publication of the American Academy of Optometry
Pukhraj Rishi, Abhinav Dhami, Jyotirmay Biswas
Biopsy involves the surgical removal of a tissue specimen for histopathologic evaluation. Most intraocular tumors are reliably diagnosed based on the clinical evaluation or with noninvasive diagnostic techniques. However, accurately diagnosing a small percentage of tumors can be challenging. A tissue biopsy is thus needed to establish a definitive diagnosis and plan the requisite treatment. From fine-needle aspiration biopsy (FNAB) to surgical excision, all tissue collection techniques have been studied in the literature...
June 2016: Indian Journal of Ophthalmology
Reid Hoshide, Mark Calayag, Hal S Meltzer, Michael L Levy, David D Gonda
INTRODUCTION: Endoscopic third ventriculostomy (ETV) is an established and effective treatment for obstructive hydrocephalus. In its most common application, surgeons plan their entry point and endoscope trajectory for the procedure based on anatomic landmarks, then free-handedly control the endoscope. We have introduced the Rosa robot assistance to our ETV procedure to stereotactically optimize endoscope trajectories, to reduce risk of traction on neural structures by the endoscope, and to provide a stable mechanical holder of the endoscope...
August 2016: Neurosurgery
Rumana N Hussain, Helen Kalirai, Carl Groenewald, Andrzej Kacperek, R Douglas Errington, Sarah Ellen Coupland, Heinrich Heimann, Bertil Damato
No abstract text is available yet for this article.
October 2016: Ophthalmology
Elona Dhrami-Gavazi, K Bailey Freund, Winston Lee, Ben Z Cohen, Surya V Seshan, Lawrence A Yannuzzi
PURPOSE: To demonstrate unusual retinal findings in a patient with progressive renal failure due to idiopathic monoclonal immunoglobulin light chain deposition disease, using multimodal imaging. METHODS: Observational case report of a 43-year-old white man with renal failure due to light chain deposition disease. His course over 6 years was documented with multimodal imaging including fundus photography, fundus autofluorescence, fluorescein angiography, and spectral domain optical coherence tomography...
June 16, 2016: Retinal Cases & Brief Reports
Vivek B Pandya, Claire Y Hooper, Rohan Merani, Peter McCluskey
PURPOSE: The authors report a rare case of systemic sarcoidosis manifesting as bilateral granulomatous panuveitis and multiple tattoo granulomas. METHODS: Case report. RESULTS: A 30-year-old man presented with headaches, ocular pain, photophobia, and blurred vision. He was found to have significant skin inflammation, predominantly involving areas of tattoos. Fundoscopic examination revealed bilateral granulomatous panuveitis with small focal choroidal lesions...
June 2, 2016: Retinal Cases & Brief Reports
L Taran-Munteanu, A Hartkopf, T K Eigentler, U Vogel, S Brucker, F A Taran
A 61-year-old woman developed blurred vision in her left eye in December 2006. A clinical diagnosis of choroidal melanoma was made. The patient underwent excision of the left lens, followed by vitrectomy and stereotactic radiotherapy. She remained systemically healthy until 50 months later when, during a CT scan done for staging purposes, a newly visible lump was noted in the lower quadrant of her left breast. Core needle biopsy of the lesion in the left breast was performed, and histologic examination revealed metastasis from the choroidal melanoma...
May 2016: Geburtshilfe und Frauenheilkunde
Aleksandra Radosavljević, Vesna Jakšić, Lato Pezo, Dragana Kovačević-Pavićević, Aleksandra Ilić, Violeta Mihailović Vučinić
PURPOSE: To analyze clinical characteristics of ocular sarcoidosis in a group of biopsy-proven sarcoid patients treated at the single referral center for sarcoidosis in Serbia. METHODS: A prospective study carried out on 88 biopsy-proven sarcoid patients between January 2012 and December 2014. All patients underwent complete ophthalmological examination. RESULTS: Ocular sarcoidosis was present in 32 patients (36.4% of all) and included: eyelid skin lesions (2...
May 18, 2016: Ocular Immunology and Inflammation
Mark P Breazzano, Ann E Barker-Griffith
BACKGROUND/AIMS: To report a case of cutaneous malignant melanoma with cerebral metastasis found to have vitreoretinal metastasis upon referral for neovascular glaucoma. METHODS: The clinical history and ocular examination findings, including histologic, cytologic, genetic, and immunohistochemical features of the vitreoretinal metastatic tumor, were reviewed. Additionally, the histologic and immunohistochemical features of the primary skin tumor and brain metastasis were also assessed...
December 2015: Ocular Oncology and Pathology
Frederick A Jakobiec, David J Ramsey, Anna M Stagner, David M Wu, Michael K Yoon
PURPOSE/BACKGROUND: To report a patient with orbital extension of a choroidal metastasis produced by a pulmonary adenocarcinoma which was diagnosed by biopsy of the extrascleral nodule. METHODS: Clinical history and imaging studies (including fundus photography, autofluorescence, fluorescein angiography, B-scan, and orbital MRI) were reviewed along with histopathologic and immunohistochemical studies. RESULTS: A 60-year-old woman presented with decreased vision in the right eye...
September 2015: Ocular Oncology and Pathology
Albert Y Cheung, Yoshihiro Yonekawa, Savitha Balaraman, Benjamin J Thomas, Alan M Xi, Robert Folberg, Mitual Amin, Kay T Miller, Lisa J Faia
PURPOSE: To provide correlative clinical-multimodal imaging-histopathologic findings of isolated prostatic choroidal metastasis. METHODS: Ophthalmologic examination, fluorescein angiogram, spectral-domain optical coherence tomography, fundus autofluorescence, computerized tomography, magnetic resonance imaging, positive emission tomography, CSF analysis, serologies, tissue pathology with immunohistochemistry, and examination of relevant literature. RESULTS: A 76-year-old man with a history of prostate adenocarcinoma was referred for 2 months of unilateral blurry vision...
April 27, 2016: Retinal Cases & Brief Reports
Scott D Walter, Daniel L Chao, William Feuer, Joyce Schiffman, Devron H Char, J William Harbour
IMPORTANCE: Uveal melanoma (UM) can be divided into prognostically significant subgroups based on a prospectively validated and widely used 15-gene expression profile (GEP) test. Class 1 UMs have a low risk and class 2 UMs have a high risk for metastasis. OBJECTIVE: To determine whether any clinicopathologic factors provide independent prognostic information that may enhance the accuracy of the GEP classification. DESIGN, SETTING, AND PARTICIPANTS: This retrospective observational study performed at 2 ocular oncology referral centers included 339 patients in a primary cohort and 241 patients in a validation cohort...
July 1, 2016: JAMA Ophthalmology
Akihiko Takeuchi, Norio Yamamoto, Katsuhiro Hayashi, Shinji Miwa, Masayuki Takahira, Kiyokazu Fukui, Taku Oikawa, Hiroyuki Tsuchiya
BACKGROUND: A tenosynovial giant cell tumor (T-GCT) is a benign synovial tumor arising from the synovium, bursae, or tendon sheath. It can be intra- or extra-articular and localized or diffuse. Diffuse T-GCT is considered as a locally aggressive. Positron emission tomography (PET) with fluorine-18 fluorodeoxyglucose with computed tomography (FDG PET/CT) is widely used to differentiate malignant from benign tumors and to detect distant metastasis. However, FDG PET/CT is limited by false-positive findings...
2016: BMC Musculoskeletal Disorders
Matthew M Zhang, Thanos D Papakostas, Arnold W Malcolm, Kristin K Ancell, Charles V Biscotti, Evangelos S Gragoudas, Anthony B Daniels
PURPOSE: Multiple choroidal melanomas arising in the same eye is a very rare entity, usually leading ophthalmologists to entertain other diagnoses. Historically, the only available treatment reported for this rare entity was enucleation. In this study we demonstrate in a series of patients with multiple simultaneous choroidal melanomas that eye salvage is possible using a variety of radiotherapy techniques. OBSERVATIONS: Both patients presented with two simultaneous choroidal melanomas in one eye...
April 15, 2016: Acta Ophthalmologica
Arman Mashayekhi, Murat Hasanreisoglu, Carol L Shields, Jerry A Shields
PURPOSE: To determine the efficacy and safety of external beam radiation for treatment of choroidal lymphoma (CL). DESIGN: Retrospective case series. PARTICIPANTS: Twenty-five eyes of 24 patients with CL treated with external beam radiation. METHOD: Review of medical records. MAIN OUTCOME MEASURES: Tumor control, visual acuity, and radiation complications. RESULTS: The mean age of the patients was 62 years (median, 65; range, 32-89 years)...
October 2016: Retina
Fanny Raguideau, Magali Lemaitre, Rosemary Dray-Spira, Mahmoud Zureik
IMPORTANCE: Several studies have focused on the current use of oral fluoroquinolones and the risk for retinal detachment (RD), but the existence of this association is under debate. Given the widespread fluoroquinolone use, investigation of this association is essential. OBJECTIVE: To assess the association between oral fluoroquinolone use and the risk for RD, including the rhegmatogenous and exudative types. DESIGN, SETTING, AND PARTICIPANTS: This case-crossover study included 27,540 adults with RD from French health care databases from July 1, 2010, through December 31, 2013...
April 2016: JAMA Ophthalmology
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"