keyword
https://read.qxmd.com/read/38040029/effectiveness-of-treatment-for-iris-melanoma-surgical-versus-radiotherapeutic-approaches
#21
REVIEW
Philip W Dockery, Joseph D DeSimone, Catherine K Liu, Kathryn Achuck, Jordan Hamburger, Zeynep Bas, Carol L Shields
OBJECTIVE: To evaluate the effectiveness of preventing metastasis for each major treatment modality for iris melanoma. DESIGN: Retrospective case series. PARTICIPANTS: Three hundred consecutive eyes with iris melanoma at a single tertiary referral centre for ocular oncology. METHODS: Retrospective analysis of eyes with iris melanoma, both with (n = 69 eyes) and without (n = 231 eyes) ciliary body extension, was undertaken for metastasis-free survival at 5, 10, and 20 years based on type of treatment, including globe-sparing surgical resection (n = 169 eyes), plaque radiotherapy (n = 74 eyes), or enucleation (n = 57 eyes)...
November 28, 2023: Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie
https://read.qxmd.com/read/38026074/ruthenium-brachytherapy-for-iris-melanoma
#22
JOURNAL ARTICLE
Emilia Zwolin Ska, Lidia Główka, Adam Chicheł, Iwona Rospond-Kubiak
PURPOSE: The study aimed to review the long-term outcomes of ruthenium brachytherapy for iris and iridociliary melanoma. MATERIAL AND METHODS: Medical records of patients who underwent ruthenium plaque treatment for iris and iridociliary melanoma at the Department of Ophthalmology, Poznań University of Medical Sciences, between 1999 and 2021 were retrospectively reviewed. RESULTS: We identified 24 patients, including 17 women and 7 men, with a median age of 61...
October 2023: Journal of Contemporary Brachytherapy
https://read.qxmd.com/read/37992353/over-diagnosis-overtreatment-or-oversurveillance-of-melanoma-is-there-a-way-out
#23
JOURNAL ARTICLE
Iris Zalaudek
No abstract text is available yet for this article.
October 1, 2023: Dermatology Practical & Conceptual
https://read.qxmd.com/read/37972025/comprehensive-causes-of-death-in-uveal-melanoma-mortality-in-1530-consecutively-diagnosed-patients-followed-until-death
#24
JOURNAL ARTICLE
Gustav Stålhammar
BACKGROUND: Uveal melanoma has a high propensity for metastatic spread. Yet, the comprehensive causes of death in a large consecutive cohort followed from diagnosis to death remain unknown. METHODS: All Swedish patients diagnosed with melanoma involving the iris, choroid, and/or ciliary body after January 1st, 1960, were assessed for this study. Sequential inclusion was halted upon encountering the first surviving patient during data collection. Causes of death were collected from the National Cause of Death Registry and audited by analysis of up to 15 causative diagnoses...
November 16, 2023: JNCI Cancer Spectrum
https://read.qxmd.com/read/37963637/targeting-the-aryl-hydrocarbon-receptor-ahr-with-bay-2416964-a-selective-small-molecule-inhibitor-for-cancer-immunotherapy
#25
JOURNAL ARTICLE
Christina Kober, Julian Roewe, Norbert Schmees, Lars Roese, Ulrike Roehn, Benjamin Bader, Detlef Stoeckigt, Florian Prinz, Mátyás Gorjánácz, Helge Gottfried Roider, Catherine Olesch, Gabriele Leder, Horst Irlbacher, Ralf Lesche, Julien Lefranc, Mine Oezcan-Wahlbrink, Ankita Sati Batra, Nirmeen Elmadany, Rafael Carretero, Katharina Sahm, Iris Oezen, Frederik Cichon, Daniel Baumann, Ahmed Sadik, Christiane A Opitz, Hilmar Weinmann, Ingo V Hartung, Bertolt Kreft, Rienk Offringa, Michael Platten, Ilona Gutcher
BACKGROUND: The metabolism of tryptophan to kynurenines (KYN) by indoleamine-2,3-dioxygenase or tryptophan-2,3-dioxygenase is a key pathway of constitutive and adaptive tumor immune resistance. The immunosuppressive effects of KYN in the tumor microenvironment are predominantly mediated by the aryl hydrocarbon receptor (AhR), a cytosolic transcription factor that broadly suppresses immune cell function. Inhibition of AhR thus offers an antitumor therapy opportunity via restoration of immune system functions...
November 2023: Journal for Immunotherapy of Cancer
https://read.qxmd.com/read/37949393/pediatric-ocular-melanoma-a-collaborative-multicenter-study-and-meta-analysis
#26
REVIEW
Babak Masoomian, Lauren A Dalvin, Hamid Riazi-Esfahani, Fariba Ghassemi, Momeneh Azizkhani, Masoud Mirghorbani, Masoud Khorrami-Nejad, Zaynab Sajjadi, Swathi Kaliki, Mandeep S Sagoo, Lamis Al Harby, Rana'a T Al-Jamal, Tero T Kivelä, Michael Giblin, Li-Anne S Lim, Carol L Shields
PURPOSE: To investigate clinical manifestations and prognoses in pediatric patients (≤12 years old) with ocular melanoma. METHODS: This was a retrospective, multicenter cohort study with individual participant data (IPD) meta-analysis pooling available published cases, and unpublished cases from an international collaboration of seven ocular oncology centers. RESULTS: There were 133 eyes of 133 pediatric patients with choroidal or ciliary body (n = 66 [50%]), iris (n = 33 [25%]), conjunctival (n = 26 [19%]), and eyelid (n = 8 [6%]) melanoma...
December 2023: Journal of AAPOS: the Official Publication of the American Association for Pediatric Ophthalmology and Strabismus
https://read.qxmd.com/read/37930181/telehealth-follow-up-consultations-for-melanoma-patients-during-the-covid-19-pandemic-patient-and-clinician-satisfaction
#27
JOURNAL ARTICLE
Ali Al-Rikaby, Ahmad Sulaiman, Jake R Thompson, Robyn P M Saw, Frances Boyle, Nicole Taylor, Matteo S Carlino, Rachael L Morton, Omgo E Nieweg, John F Thompson, Iris Bartula
INTRODUCTION: The COVID-19 pandemic caused rapid implementation of telehealth for melanoma follow-up care in Australia. This study explores Australian melanoma patients and clinicians' level of satisfaction with telehealth. METHODS: A cross-sectional study was conducted across three specialist melanoma centres in Sydney, Australia. Melanoma patients (all stages) and clinicians completed mixed methods surveys seeking socio-demographic and clinical information and questionnaires to assess satisfaction with telehealth...
November 6, 2023: Cancer Medicine
https://read.qxmd.com/read/37914164/multifocal-choroidal-melanoma-a-clinicohistopathological-correlation
#28
JOURNAL ARTICLE
Manasi Ketkar, Saumya Jakati, Vishal Raval
A woman in her late 50s presented with on-and-off redness and diminution of vision in her left eye for 6 months. Her best corrected visual acuity was 20/40 in the right eye and hand motion in the left eye. Anterior segment examination revealed a greyish-white lesion extending from 3 to 6 o'clock hours posterior to the iris and protruding into the anterior chamber. Left eye B-scan ultrasonography showed a multifocal choroidal lesion, a smaller one involving the posterior pole, and a larger lesion involving the complete nasal quadrant and anteriorly extending to the ciliary body and iris...
November 1, 2023: BMJ Case Reports
https://read.qxmd.com/read/37902747/worldwide-incidence-of-ocular-melanoma-and-correlation-with-pigmentation-related-risk-factors
#29
JOURNAL ARTICLE
Mike Wu, Serdar Yavuzyigitoglu, Erwin Brosens, Wishal D Ramdas, Emine Kiliç
PURPOSE: The worldwide incidence of ocular melanoma (OM), uveal melanoma (UM), and conjunctival melanoma has last been reported on 15 years ago. Recently, light iris color and four specific single-nucleotide-polymorphisms (SNPs) have been identified as a UM-risk factor. Furthermore, six iris color predicting SNPs have been discovered (IrisPlex). Interestingly, two of these (rs129138329 and rs12203592) are also UM-risk factors. We collected worldwide incidence data of OM and investigated its correlations with iris color, IrisPlex SNPs, and UM-risk SNPs...
October 3, 2023: Investigative Ophthalmology & Visual Science
https://read.qxmd.com/read/37889509/tumor-profiles-of-late-presentation-uveal-ring-melanoma-with-novel-characteristics-a-case-series
#30
JOURNAL ARTICLE
Joevy Z Lim, Alexandra Z Crawford, Charles N J McGhee
PURPOSE: The purpose of this study was to investigate the clinical features, tumor characteristics, including histopathology and cytogenetic analysis, and management of patients with uveal ring melanoma in New Zealand. METHODS: A retrospective review was conducted on all uveal melanoma cases treated in a single national oncology center in New Zealand. The study period was from January 1, 2013 to December 31, 2022 (10 years). Written consent was obtained from all patients included in this case series...
October 3, 2023: Investigative Ophthalmology & Visual Science
https://read.qxmd.com/read/37886558/deactivation-of-ligand-receptor-interactions-enhancing-lymphocyte-infiltration-drives-melanoma-resistance-to-immune-checkpoint-blockade
#31
Sahil Sahni, Binbin Wang, Di Wu, Saugato Rahman Dhruba, Matthew Nagy, Sushant Patkar, Ingrid Ferreira, Kun Wang, Eytan Ruppin
Immune checkpoint blockade (ICB) is a promising cancer therapy; however, resistance often develops. To learn more about ICB resistance mechanisms, we developed IRIS ( I mmunotherapy R esistance cell-cell I nteraction S canner), a machine learning model aimed at identifying candidate ligand-receptor interactions (LRI) that are likely to mediate ICB resistance in the tumor microenvironment (TME). We developed and applied IRIS to identify resistance-mediating cell-type-specific ligand-receptor interactions by analyzing deconvolved transcriptomics data of the five largest melanoma ICB therapy cohorts...
September 22, 2023: bioRxiv
https://read.qxmd.com/read/37865279/iris-melanoma-review-of-clinical-features-risks-management-and-outcomes
#32
JOURNAL ARTICLE
Elliot Cherkas, Nicholas E Kalafatis, Molly R Marous, Carol L Shields
Primary uveal melanoma is rare and affects approximately 8,000 persons per year worldwide. This malignancy can involve the iris, ciliary body, and choroid. Of these three structures, the iris is the least commonly affected site, representing only 4% of all uveal melanomas. Iris melanoma can arise from iris melanocytic nevus, iris melanocytosis, or de novo. In a longitudinal study of 1,611 patients followed with iris nevus, transformation into melanoma, using Kaplan-Meier estimates, was found in 2.6% by 5 years and 4...
October 19, 2023: Clinics in Dermatology
https://read.qxmd.com/read/37847007/two-melanomas-one-eye
#33
JOURNAL ARTICLE
Rachel Shemesh, Tal Serlin, Iris Moroz, Vicktoria Vishnevskia-Dai
No abstract text is available yet for this article.
October 2023: Israel Medical Association Journal: IMAJ
https://read.qxmd.com/read/37772381/-corrigendum-melanogenesis-in-uveal-melanoma-cells-%C3%A2-effect-of-argan-oil
#34
Nunzia Caporarello, Melania Olivieri, Martina Cristaldi, Dario Rusciano, Gabriella Lupo, Carmelina Daniela Anfuso
Following the publication of the above article, an interested reader drew to the authors' attention that, in Fig. 7 on p. 1282, a pair of the western blotting bands in the Akt blot positioned adjacent to each other looked strikingly similar. Although the authors considered that the data were correct as shown (and the Editorial Office were in agreement that it was not certain that the bands were identical), to avoid any possible confusion or suspicion, the authors requested that the figure be reprinted showing the Akt data obtained from one of the repeated experiments...
November 2023: International Journal of Molecular Medicine
https://read.qxmd.com/read/37770421/dermoscopy-of-atypical-pigmented-lesions-of-the-face-variation-according-to-facial-areas
#35
JOURNAL ARTICLE
Linda Tognetti, Alessandra Cartocci, Elisa Cinotti, Martina Donghia, Magdalena Żychowska, Elvira Moscarella, Emi Dika, Francesca Farnetani, Stefania Guida, John Paoli, Aimilios Lallas, Danica Tiodorovic, Ignazio Stanganelli, Caterina Longo, Mariano Suppa, Iris Zalaudek, Giuseppe Argenziano, Jean Luc Perrot, Giovanni Rubegni, Gennaro Cataldo, Pietro Rubegni
Atypical pigmented facial lesions (aPFLs)-including lentigo maligna (LM) and lentigo maligna melanoma (LMM), solar lentigo (SL), pigmented actinic keratosis (PAK), atypical nevi (AN), seborrheic keratosis (SK) and lichen planus-like keratosis (LPLK)-can exhibit clinical and dermoscopic overlapping features. We aimed to investigate if and how 14 dermoscopic features suggestive for the aforementioned aPFLs vary according to six facial sites among 1197 aPFLs cases (excised to rule out malignancy) along with lesion and patients' metadata...
September 28, 2023: Experimental Dermatology
https://read.qxmd.com/read/37763109/carpal-tunnel-syndrome-associated-with-immune-checkpoint-inhibitors
#36
JOURNAL ARTICLE
Alexander Yakobson, Keren Rouvinov, Aharon Y Cohen, Iris Goldstein, Omar Abu Saleh, Adam Solomon, Yulia Dudnik, Walid Shalata
Immune checkpoint inhibitors (ICIs) have transformed the therapeutic approach to diverse malignancies, leading to substantial enhancements in patient prognosis. However, along with their benefits, ICIs also increase the incidence of immune-related adverse events (irAEs). In the present paper, we highlight four cases of carpal tunnel syndrome (CTS) as an uncommon manifestation of toxicity induced by ICIs. Although diagnosed with different malignancies, the patients were undergoing ICI therapy when they developed CTS-consistent side effects accompanied by severe neuropathy...
August 30, 2023: Journal of Personalized Medicine
https://read.qxmd.com/read/37760619/clinical-outcomes-in-ayas-adolescents-and-young-adults-treated-with-proton-therapy-for-uveal-melanoma-a-comparative-matching-study-with-elder-adults
#37
JOURNAL ARTICLE
Alessia Pica, Damien C Weber, Claude Schweizer, Aziz Chaouch, Leonidas Zografos, Ann Schalenbourg
OBJECTIVE: The aim of this study was to compare the clinical outcomes of adolescents and young adults (AYAs) with those of elder adult patients treated with proton therapy (PT) for uveal melanoma (UM). MATERIAL AND METHODS: A retrospective, comparative study was conducted in UM patients who underwent PT at the Ocular Oncology Unit of the Jules-Gonin Eye Hospital (University of Lausanne, Lausanne, Switzerland) and the Paul Scherrer Institute (PSI); (Villigen, Switzerland) between January 1997 and December 2007...
September 20, 2023: Cancers
https://read.qxmd.com/read/37758183/diode-laser-ablation-of-progressive-pigmented-iris-lesions-in-317-cats-356-eyes-appears-overall-safe-and-effective-in-decreasing-progression-of-iris-pigmentation
#38
JOURNAL ARTICLE
Allison A Fuchs, Elizabeth A Giuliano, Robert English, Brad Nadelstein
OBJECTIVE: To describe a novel scoring system of feline pigmented iris lesions prior to utilization of diode laser ablation of progressive pigmented iris lesions and to retrospectively evaluate short- and long-term patient outcomes following transcorneal diode laser ablation. ANIMALS: 317 client-owned cats (356 eyes) were included. CLINICAL PRESENTATION: Records of cats undergoing diode laser ablation from January 2000 to December 2018 were retrospectively reviewed...
September 27, 2023: Journal of the American Veterinary Medical Association
https://read.qxmd.com/read/37733045/multiple-iris-nevi-in-an-eye-with-ciliochoroidal-melanoma
#39
JOURNAL ARTICLE
Ari J Clements, Jennifer S Zeiger, Carol L Shields
No abstract text is available yet for this article.
September 1, 2023: JAMA Ophthalmology
https://read.qxmd.com/read/37689267/expert-agreement-on-the-presence-and-spatial-localization-of-melanocytic-features-in-dermoscopy
#40
JOURNAL ARTICLE
Konstantinos Liopyris, Cristian Navarrete-Dechent, Michael A Marchetti, Veronica Rotemberg, Zoe Apalla, Giuseppe Argenziano, Andreas Blum, Ralph P Braun, Cristina Carrera, Noel C F Codella, Marc Combalia, Stephen W Dusza, David A Gutman, Brian Helba, Rainer Hofmann-Wellenhof, Natalia Jaimes, Harald Kittler, Kivanc Kose, Aimilios Lallas, Caterina Longo, Josep Malvehy, Scott Menzies, Kelly C Nelson, John Paoli, Susana Puig, Harold S Rabinovitz, Ayelet Rishpon, Teresa Russo, Alon Scope, H Peter Soyer, Jennifer A Stein, Willhelm Stolz, Dimitrios Sgouros, Alexander J Stratigos, David L Swanson, Luc Thomas, Philipp Tschandl, Iris Zalaudek, Jochen Weber, Allan C Halpern, Ashfaq A Marghoob
Dermoscopy aids in melanoma detection; however, agreement on dermoscopic features, including those of high clinical relevance, remains poor. Herein we attempted to evaluate agreement among experts on 'exemplar images' not only for the presence of melanocytic-specific features but also for spatial localization. This was a cross-sectional, multicenter, observational study. Dermoscopy images exhibiting at least one of 31 melanocytic-specific features were submitted by 25 world experts as 'exemplars'. Using a web-based platform that allows for image mark-up of specific contrast-defined regions (superpixels), 20 expert readers annotated 248 dermoscopic images in collections of 62 images...
September 7, 2023: Journal of Investigative Dermatology
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