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Iris melanoma

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https://www.readbyqxmd.com/read/29156467/-diagnosis-and-therapy-of-iris-lesions
#1
Joel M Mor, Konrad R Koch, Ludwig M Heindl
The most common iris lesions are iris nevi, iris melanomas and iris pigment epithelium cysts. However, there is an abundance of rare differential diagnoses that have to be considered, including other melanocytic and non-melanocytic lesions. Diagnostic tools include the slit lamp examination, gonioscopy, tonometry, transillumination, ultrasound biomicroscopy (UBM), optical coherence tomography, fluorescein angiography and standardized photography-assisted documentation. The timely identification of malignant lesions (i...
November 20, 2017: Klinische Monatsblätter Für Augenheilkunde
https://www.readbyqxmd.com/read/29150959/nono-ubiquitination-is-mediated-by-fbw7-and-gsk3-%C3%AE-via-a-degron-lost-upon-chromosomal-rearrangement-in-cancer
#2
Luigi Alfano, Antonella Caporaso, Angela Altieri, Caterina Costa, Iris M Forte, Carmelina A Iannuzzi, Daniela Barone, Luca Esposito, Antonio Giordano, Francesca Pentimalli
NONO is an RNA-binding protein involved in transcription, mRNA splicing, DNA repair and checkpoint activation in response to UV radiation. NONO expression has been found altered in several tumour types, including prostate, colon, breast, melanoma and in papillary renal carcinoma, in which an X chromosome inversion generates a NONO-TFE3 fusion protein. Upon such rearrangement, NONO loses its C-terminal domain. Through bioinformatics analysis, we identified a putative degron motif, known to be recognized by the Skp1-Cul1-F-box-protein (SCF) complex...
November 18, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29135712/limbal-stem-cell-preservation-during-proton-beam-irradiation-for-diffuse-iris-melanoma
#3
Paul T Finger, Wolfgang A G Sauerwein
No abstract text is available yet for this article.
November 13, 2017: Cornea
https://www.readbyqxmd.com/read/29128229/proton-beam-therapy-for-iris-melanomas-in-107-patients
#4
Juliette Thariat, Ahmed Rahmi, Julia Salleron, Carlo Mosci, Benjamin Butet, Celia Maschi, Francesco Lanza, Sara Lanteri, Stephanie Baillif, Joel Herault, Thibaud Mathis, Jean Pierre Caujolle
PURPOSE: To report on the clinical characteristics and outcomes for patients with iris melanoma using proton therapy. DESIGN: Retrospective study. PARTICIPANTS: One hundred seven patients with iris melanoma from 3 regional ophthalmologic centers. METHODS: A retrospective study was conducted for iris melanoma patients from 3 regional ophthalmologic centers referred to and treated at a single proton therapy facility between 1996 and 2015...
November 8, 2017: Ophthalmology
https://www.readbyqxmd.com/read/29122824/ruthenium-106-brachytherapy-for-iris-and-iridociliary-melanomas
#5
Marina Marinkovic, Nanda Horeweg, Mirjam S Laman, Jaco C Bleeker, Martijn Ketelaars, Femke P Peters, Gre P M Luyten, Carien L Creutzberg
BACKGROUND AND PURPOSE: To evaluate ruthenium-106 (Ru106) brachytherapy as eye-conserving treatment of iris melanomas (IMs) and iridociliary melanomas (ICMs). MATERIALS AND METHODS: Eighty-eight patients received Ru106 brachytherapy between 2006 and 2016. Primary outcome was local control, and secondary outcomes were metastasis, survival, eye preservation, complications and visual acuity (VA). RESULTS: Overall median follow-up was 36 months...
November 9, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/29082081/human-iris-three-dimensional-imaging-at-micron-resolution-by-a-micro-plenoptic-camera
#6
Hao Chen, Maria A Woodward, David T Burke, V Swetha E Jeganathan, Hakan Demirci, Volker Sick
A micro-plenoptic system was designed to capture the three-dimensional (3D) topography of the anterior iris surface by simple single-shot imaging. Within a depth-of-field of 2.4 mm, depth resolution of 10 µm can be achieved with accuracy (systematic errors) and precision (random errors) below 20%. We demonstrated the application of our micro-plenoptic imaging system on two healthy irides, an iris with naevi, and an iris with melanoma. The ridges and folds, with height differences of 10~80 µm, on the healthy irides can be effectively captured...
October 1, 2017: Biomedical Optics Express
https://www.readbyqxmd.com/read/29042650/handheld-photoacoustic-microscopy-probe
#7
Kyungjin Park, Jin Young Kim, Changho Lee, Seungwan Jeon, Geunbae Lim, Chulhong Kim
Optical resolution photoacoustic microscopy (OR-PAM) is a non-invasive, label-free method of in vivo imaging with microscopic resolution and high optical contrast. Based on intrinsic contrasts, OR-PAM has expanded to include in vivo vessel imaging, flow cytometry, physiological parameter analysis, and single-cell characterization. However, since conventional OR-PAM systems have a fixed tabletop configuration, a large system size, and slow imaging speed, their use in preclinical and clinical studies remains limited...
October 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29038913/-ocular-melanomas-an-update
#8
REVIEW
H Kalirai, P L Müller, D Jaehne, S E Coupland
Melanoma is the most common type of primary cancer to affect the adult eye. Approximately 95% of ocular melanomas are intraocular and arise from the uvea (i. e. iris, ciliary body, and choroid), while the remaining 5% are located in the conjunctiva. Although both uveal and conjunctival melanomas are thought to derive from malignantly transformed melanocytes, uveal melanoma is clinically and biologically distinct from conjunctival melanoma, and indeed from its more common cutaneous counterpart. Intense efforts have been recently made to understand the molecular biology involved in the development of ocular melanomas, and in their progression...
November 2017: Der Pathologe
https://www.readbyqxmd.com/read/28971066/clinical-and-research-activities-at-the-catana-facility-of-infn-lns-from-the-conventional-hadrontherapy-to-the-laser-driven-approach
#9
Giuseppe A P Cirrone, Giacomo Cuttone, Luigi Raffaele, Vincenzo Salamone, Teresio Avitabile, Giuseppe Privitera, Corrado Spatola, Daniele Margarone, Valeria Patti, Giada Petringa, Francesco Romano, Andrea Russo, Antonio Russo, Maria G Sabini, Valentina Scuderi, Francesco Schillaci, Lucia M Valastro
The CATANA proton therapy center was the first Italian clinical facility making use of energetic (62 MeV) proton beams for the radioactive treatment of solid tumors. Since the date of the first patient treatment in 2002, 294 patients have been successful treated whose majority was affected by choroidal and iris melanomas. In this paper, we report on the current clinical and physical status of the CATANA facility describing the last dosimetric studies and reporting on the last patient follow-up results. The last part of the paper is dedicated to the description of the INFN-LNS ongoing activities on the realization of a beamline for the transport of laser-accelerated ion beams for future applications...
2017: Frontiers in Oncology
https://www.readbyqxmd.com/read/28937525/choroidal-melanoma-in-phakomatosis-pigmentovascularis-with-klippel-trenaunay-syndrome
#10
Carol L Shields, Maura Di Nicola, Marco Pellegrini, Jerry A Shields
PURPOSE: To describe the relationship of choroidal melanoma with phakomatosis pigmentovascularis in patients with Klippel-Trenaunay syndrome. METHODS: Retrospective review of 5 patients. RESULTS: In all 5 cases, the patient was white and the cutaneous port-wine stain was congenital. The port-wine stain involved the chin (n = 1), jawline (n = 2), lower cheek (n = 1), thorax (n = 5), abdomen (n = 4), upper (n = 4), and lower (n = 3) limb(s)...
September 20, 2017: Retina
https://www.readbyqxmd.com/read/28882848/orbital-recurrence-of-iris-melanoma-21-years-after-enucleation
#11
Emilie Bergeron, Nadia Lihimdi, Dan Bergeron, Solange Landreville
We present the case of a 56-year-old man who developed a neoplasm of epithelioid histology in his anophthalmic left orbit 21 years after he underwent enucleation for a spindle cell iris melanoma. The recurrent tumour was managed by orbital exenteration. Neither further recurrence nor metastasis was diagnosed over a 5-year follow-up period. This case, along with five other similar cases in the literature,(1-3) emphasises the importance of long-term follow-up after treatment of iris melanoma.
September 7, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28868012/treatment-of-primary-and-metastatic-multifocal-mucosal-melanoma-of-the-oral-cavity-with-imatinib
#12
Teresa Deinlein, Ingrid H Wolf, Barbara Rainer, Romana Kupsa, Erika Richtig, Rainer Hofmann-Wellenhof, Iris Zalaudek
BACKGROUND: Mucosal melanoma of the oral cavity is a rare entity and accounts for less than 1-3% of all melanomas. Contrary to cutaneous melanoma, primary oral melanoma more commonly harbors mutations in c-KIT. METHODS: A 64-year-old man presented with asymptomatic, multiple, brown-to-black macules in the oral cavity. A biopsy was taken and histopathology exhibited mucosal melanoma. In molecular analysis, a c-KIT mutation was proven and a CT scan revealed pulmonary metastases...
May 2017: Case Reports in Oncology
https://www.readbyqxmd.com/read/28845329/evaluation-of-iris-melanoma-with-anterior-segment-optical-coherence-tomography
#13
Mehtap Arslantürk Eren, Ahmet Kaan Gündüz, Özlenen Ömür Gündüz
Anterior segment optical coherence tomography (AS-OCT) is a relatively new imaging modality that allows assessment of anterior segment structures. AS-OCT enables the differentiation of benign and malignant tumors through the evaluation of lesion size, internal structure, degree of vascularity, and anterior and posterior surfaces. Herein, we discuss the AS-OCT findings of a patient with spindle type iridociliary melanoma diagnosed in pathologic examination.
August 2017: Turkish Journal of Ophthalmology
https://www.readbyqxmd.com/read/28844752/multifocal-iris-melanoma-in-a-2-year-old-managed-with-i-125-plaque-brachytherapy
#14
Andrew R Lee, Dilraj S Grewal, Thomas J Cummings, Laura B Enyedi, Nicole A Larrier, Prithvi Mruthyunjaya
We report a 23-month-old patient presenting with multifocal iris melanoma who underwent plaque brachytherapy with full corneal coverage. The lesion demonstrated several high-risk clinical and histopathologic features associated with iris melanoma in adults, including growth and angle seeding. The patient has been subsequently followed for 3.5 years with no evidence of recurrence. This report demonstrates the importance of serial examination of suspected melanocytic iris lesions in very young children and the effective treatment option of globe-sparing radiation therapy...
August 26, 2017: Journal of AAPOS: the Official Publication of the American Association for Pediatric Ophthalmology and Strabismus
https://www.readbyqxmd.com/read/28837522/risk-factors-and-clinical-outcomes-in-patients-with-ibd-with-melanoma
#15
Loes H C Nissen, Marieke Pierik, Lauranne A A P Derikx, Elke de Jong, Wietske Kievit, Tim R A van den Heuvel, Alexander R van Rosendael, Elsemieke I Plasmeijer, Pieter Dewint, Rob H A Verhoeven, Lucy I H Overbeek, Iris D Nagtegaal, Frank Hoentjen, Andrea E van der Meulen-de Jong
BACKGROUND: Patients with inflammatory bowel disease (IBD) are at increased risk to develop malignant melanoma and this risk may increase with use of anti-tumor necrosis factor (TNF) therapy. Impaired survival of immunosuppressed melanoma patients is reported in transplant and rheumatology patients. This study aims to (1) identify risk factors for melanoma development in patients with IBD, (2) compare clinical characteristics of melanoma in patients with IBD to the general population, and (3) assess the influence of immunosuppressive medication on survival...
November 2017: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/28799019/endometriosis-and-the-risk-of-skin-cancer-a-prospective-cohort-study
#16
Leslie V Farland, Simon Lorrain, Stacey A Missmer, Laureen Dartois, Iris Cervenka, Isabelle Savoye, Sylvie Mesrine, Marie-Christine Boutron-Ruault, Marina Kvaskoff
PURPOSE: Endometriosis has been associated with an increased risk of skin melanoma. However, associations with other skin cancer types and how they compare with melanoma are unclear. Our objective was to prospectively investigate the relationships between endometriosis and risk of non-melanoma and melanoma skin cancers. METHODS: E3N is a prospective cohort of 98,995 French women aged 40-65 years in 1990. Data on surgically confirmed endometriosis and skin cancer diagnoses were collected every 2-3 years through self-report, with skin cancer cases confirmed through pathology reports...
October 2017: Cancer Causes & Control: CCC
https://www.readbyqxmd.com/read/28762556/nadph-oxidase-5-nox5-induced-reactive-oxygen-signaling-modulates-normoxic-hif-1%C3%AE-and-p27-kip1-expression-in-malignant-melanoma-and-other-human-tumors
#17
Smitha Antony, Guojian Jiang, Yongzhong Wu, Jennifer L Meitzler, Hala R Makhlouf, Diana C Haines, Donna Butcher, Dave S Hoon, Jiuping Ji, Yiping Zhang, Agnes Juhasz, Jiamo Lu, Han Liu, Iris Dahan, Mariam Konate, Krishnendu K Roy, James H Doroshow
NADPH oxidase 5 (NOX5) generated reactive oxygen species (ROS) have been implicated in signaling cascades that regulate cancer cell proliferation. To evaluate and validate NOX5 expression in human tumors, we screened a broad range of tissue microarrays (TMAs), and report substantial overexpression of NOX5 in malignant melanoma and cancers of the prostate, breast, and ovary. In human UACC-257 melanoma cells that possesses high levels of functional endogenous NOX5, overexpression of NOX5 resulted in enhanced cell growth, increased numbers of BrdU positive cells, and increased γ-H2AX levels...
December 2017: Molecular Carcinogenesis
https://www.readbyqxmd.com/read/28761960/seven-non-melanoma-features-of-facial-lesions-a-dermatoscopy-algorithm-to-rule-out-melanoma
#18
Philipp Tschandl, Alessio Gambardella, Amélie Boespflug, Teresa Deinlein, Vincenzo de Giorgi, Harald Kittler, Aimilios Lallas, Josep Malvehy, Elvira Moscarella, Susana Puig, Massimiliano Scalvenzi, Luc Thomas, Iris Zalaudek, Roberto Alfano, Giuseppe Argenziano
Facial melanoma is difficult to diagnose and dermatoscopic features are often subtle. Dermatoscopic non-melanoma patterns may have a comparable diagnostic value. In this pilot study, facial lesions were collected retrospectively, resulting in a case set of 339 melanomas and 308 non-melanomas. Lesions were evaluated for the prevalence (> 50% of lesional surface) of 7 dermatoscopic non-melanoma features: scales, white follicles, erythema/reticular vessels, reticular and/or curved lines/fingerprints, structureless brown colour, sharp demarcation, and classic criteria of seborrhoeic keratosis...
August 1, 2017: Acta Dermato-venereologica
https://www.readbyqxmd.com/read/28757700/brachytherapy-and-anterior-segment-imaging-in-iris-melanoma
#19
Jin Soo Andy Song, Adam A Dmytriw, Hesham Lakosha
Ultrasound biomicroscopy (UBM) remains a potent tool in the diagnosis and characterization of uveal lesions. In the setting of malignancy, it can confirm both placement of and response to brachytherapy. We present a case of iris melanoma with aggressive BAP-1 mutation, treated successfully with I-131 brachytherapy which was both characterized and followed with UBM and thereafter discuss the current state of these modalities.
May 2017: Oman Journal of Ophthalmology
https://www.readbyqxmd.com/read/28743137/-surgical-methods-in-the-treatment-of-uveal-melanoma
#20
Georgios Blatsios, Gertrud Haas, Claus Zehetner, Nikolaos E Bechrakis
Significant advancements have been made in the last decades in the treatment of uveal melanoma. Radiation therapy can achieve, depending on the method, local tumour control in up to 98% of cases. Surgical modalities have been implemented in the ocular therapy for uveal melanoma either to treat/prevent radiation complications, such as so-called toxic tumour syndrome, or to primarily treat the tumour with or without adjunctive radiotherapy. These include endoresection and transscleral resection for melanomas of the choroid/ciliary body or irido-trabeculo-cyclectomy for melanomas of the iris-ciliary body...
July 2017: Klinische Monatsblätter Für Augenheilkunde
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