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Iris melanoma

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https://www.readbyqxmd.com/read/28062196/radiotherapeutic-and-surgical-management-of-iris-melanoma-a-review
#1
REVIEW
Marko Popovic, Iqbal Ike K Ahmed, Julia DiGiovanni, Carol L Shields
We compare outcomes following radiotherapeutic and surgical management of iris melanoma. Endpoints included local tumor recurrence, metastases, and common complications. From an initial search that yielded 231 articles, we found 17 relevant studies with 761 eyes. The gender distribution was balanced with a mean age of 52 years. Most studies focused on either proton beam (49.4%) or plaque (31.4%) radiotherapy. Rates of local recurrence (range: 0-8%) and metastatic development (0-5%) were favorable following radiotherapy; however, common complications included cataract (36-73%), glaucoma (3-92%) and corneal conditions (0-33%)...
January 3, 2017: Survey of Ophthalmology
https://www.readbyqxmd.com/read/28052277/unknown-primary-melanoma-worldwide-survey-on-clinical-management
#2
Simone Ribero, Riccardo Pampena, Veronique Bataille, Elvira Moscarella, Luc Thomas, Pietro Quaglino, Concetta Potenza, Alexander C J Van Akkooi, Alessandro Testori, Paul Nathan, Susana Puig, Iris Zalaudek, Giuseppe Argenziano, Caterina Longo
BACKGROUND: How to deal with melanoma of unknown primary (MUP) origin is a debated topic in the literature. OBJECTIVE: We performed a worldwide survey to inquire what clinical and investigational workup is performed as well as the physicians' perception of this disease. METHODS: A questionnaire was sent via mail to clinicians involved in melanoma care from December 2015 to April 2016 using the International Dermoscopy Society website. RESULTS: 119 physicians from 47 different countries answered the questionnaire...
January 5, 2017: Dermatology: International Journal for Clinical and Investigative Dermatology
https://www.readbyqxmd.com/read/27993903/study-protocol-for-a-prospective-non-controlled-multicentre-clinical-study-to-evaluate-the-diagnostic-accuracy-of-a-stepwise-two-photon-excited-melanin-fluorescence-in-pigmented-lesions-suspicious-for-melanoma-flimma-study
#3
Christine Fink, Maja Hofmann, Agata Jagoda, Iris Spaenkuch, Andrea Forschner, Ioanna Tampouri, Diana Lomberg, Dieter Leupold, Claus Garbe, Holger A Haenssle
INTRODUCTION: Non-invasive, nanosecond, stepwise two-photon laser excitation of skin tissue was shown to induce melanin fluorescence spectra that allow for the differentiation of melanocytic nevi from cutaneous melanoma. METHODS AND ANALYSIS: This prospective, non-controlled, multicentre clinical study is performed to evaluate the diagnostic performance of the stepwise two-photon excited melanin fluorescence in the detection of cutaneous melanoma. The comparator will be the histopathological diagnosis...
December 19, 2016: BMJ Open
https://www.readbyqxmd.com/read/27973568/yessotoxin-a-marine-toxin-exhibits-anti-allergic-and-anti-tumoural-activities-inhibiting-melanoma-tumour-growth-in-a-preclinical-model
#4
Araceli Tobío, Amparo Alfonso, Iris Madera-Salcedo, Luis M Botana, Ulrich Blank
Yessotoxins (YTXs) are a group of marine toxins produced by the dinoflagellates Protoceratium reticulatum, Lingulodinium polyedrum and Gonyaulax spinifera. They may have medical interest due to their potential role as anti-allergic but also anti-cancer compounds. However, their biological activities remain poorly characterized. Here, we show that the small molecular compound YTX causes a slight but significant reduction of the ability of mast cells to degranulate. Strikingly, further examination revealed that YTX had a marked and selective cytotoxicity for the RBL-2H3 mast cell line inducing apoptosis, while primary bone marrow derived mast cells were highly resistant...
2016: PloS One
https://www.readbyqxmd.com/read/27939562/results-in-combined-cataract-surgery-with-prosthetic-iris-implantation-in-patients-with-previous-iridocyclectomy-for-iris-melanoma
#5
Michael E Snyder, Robert H Osher, Trisha M Wladecki, Mauricio A Perez, James J Augsburger, Zélia Corrêa
PURPOSE: To present visual and functional results following implantation of iris prosthesis combined with cataract surgery in eyes with previous iridocyclectomy for iris melanoma or presumed iris melanoma. DESIGN: Retrospective non-comparative case series METHODS: Sixteen patients (16 eyes) with iris defects after iridocyclectomy for iris melanoma in 15 cases and iris adenoma in 1 case underwent prosthetic iris device implantation surgery. Prosthetic iris implantation was combined with phacoemulsification and intraocular lens (IOL) implantation...
December 6, 2016: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/27911450/uveal-melanoma-relatively-rare-but-deadly-cancer
#6
REVIEW
S Kaliki, C L Shields
Although it is a relatively rare disease, primarily found in the Caucasian population, uveal melanoma is the most common primary intraocular tumor in adults with a mean age-adjusted incidence of 5.1 cases per million per year. Tumors are located either in iris (4%), ciliary body (6%), or choroid (90%). The host susceptibility factors for uveal melanoma include fair skin, light eye color, inability to tan, ocular or oculodermal melanocytosis, cutaneous or iris or choroidal nevus, and BRCA1-associated protein 1 mutation...
December 2, 2016: Eye
https://www.readbyqxmd.com/read/27879009/epidemiological-dermoscopical-and-pathological-evaluation-of-melanocytic-lesions-of-the-buttock-in-a-5-year-period-a-female-prevalence
#7
LETTER
G Paolino, I Zalaudek, A Carbone, P Frascione, M Donati, C Panetta, P Donati
No abstract text is available yet for this article.
November 23, 2016: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/27856029/optical-coherence-tomography-angiography-characteristics-of-iris-melanocytic-tumors
#8
Alison H Skalet, Yan Li, Chen D Lu, Yali Jia, ByungKun Lee, Lennart Husvogt, Andreas Maier, James G Fujimoto, Charles R Thomas, David Huang
PURPOSE: To evaluate tumor vasculature with optical coherence tomography angiography (OCTA) in malignant iris melanomas and benign iris lesions. DESIGN: Cross-sectional observational clinical study. PARTICIPANTS: Patients with iris lesions and healthy volunteers. METHODS: Eyes were imaged using OCTA systems operating at 1050- and 840-nm wavelengths. Three-dimensional OCTA scans were acquired. Iris melanoma patients treated with radiation therapy were imaged again after I-125 plaque brachytherapy at 6 and 18 months...
November 14, 2016: Ophthalmology
https://www.readbyqxmd.com/read/27821903/proteomic-approaches-to-biomarker-discovery-in-cutaneous-t-cell-lymphoma
#9
REVIEW
Alexandra Ion, Iris Maria Popa, Laura Maria Lucia Papagheorghe, Cristina Lisievici, Mihai Lupu, Vlad Voiculescu, Constantin Caruntu, Daniel Boda
Cutaneous T-cell lymphoma (CTCL) is the most frequently encountered type of skin lymphoma in humans. CTCL encompasses multiple variants, but the most common types are mycosis fungoides (MF) and Sezary syndrome (SS). While most cases of MF run a mild course over a period of many years, other subtypes of CTCL are very aggressive. The rapidly expanding fields of proteomics and genomics have not only helped increase knowledge concerning the carcinogenesis and tumor biology of CTCL but also led to the discovery of novel markers for targeted therapy...
2016: Disease Markers
https://www.readbyqxmd.com/read/27800275/uveal-melanoma-current-trends-in-diagnosis-and-management
#10
REVIEW
Berçin Tarlan, Hayyam Kıratlı
Uveal melanoma, which is the most common primary intraocular malignancy in adults, arises from melanocytes within the iris, ciliary body and choroid. The diagnosis is based principally on clinical examination of the tumor with biomicroscopy and indirect ophthalmoscopy and confirmed by diagnostic techniques such as ultrasonography, fundus fluorescein angiography and optical coherence tomography. The clinical diagnosis of posterior uveal melanomas can be made when the classical appearance of a pigmented dome-shaped mass is detected on dilated fundus exam...
June 2016: Turkish Journal of Ophthalmology
https://www.readbyqxmd.com/read/27790134/optical-coherence-tomography-angiography-of-iris-nevus-a-case-report
#11
Davide Allegrini, Giovanni Montesano, Alfredo Pece
Iris nevus is common: 6% of patients with suspected iris melanoma have lesions other than melanoma, and 36% of them are nevi. Iris nevus turns into melanoma in approximately 8% of cases at a mean of 15 years. This case report provides the first description of an iris tumor examined with iris optical coherence tomography angiography (OCTA) compared to iris fluorescein angiography (IFA). A 60-year-old man with a diagnosis of iris nevus in the left eye was referred to our department for IFA and iris OCTA. The iris vasculature in IFA was visible only in the early phases, but not clearly...
September 2016: Case Reports in Ophthalmology
https://www.readbyqxmd.com/read/27755196/limbal-stem-cell-preservation-during-proton-beam-irradiation-for-diffuse-iris-melanoma
#12
Arun D Singh, William J Dupps, Charles V Biscotti, John H Suh, Kira L Lathrop, John P Nairn, Helen Shih
PURPOSE: To report the outcome after limbal stem cell preservation during proton beam irradiation for diffuse iris melanoma. METHODS: This is a single-case report of diffuse iris melanoma that was managed with proton beam radiation (53 Gy), wherein preemptively harvested superior and inferior limbal stem cells before radiation were replaced after irradiation. Regeneration of the palisades of Vogt and the limbal stem cells was documented by an optical coherence tomography-based imaging protocol...
January 2017: Cornea
https://www.readbyqxmd.com/read/27746064/melanomalytic-glaucoma-secondary-to-iris-melanoma
#13
S Ajamil Rodanés, C García-Álvarez, M A Saornil Alvarez, F López-Lara, J M Frutos Baraja, M Quiñones
CLINICAL CASE: A 35-year-old male with unilateral ocular hypertension in the right eye (RE). Anterior segment examination of the RE showed a melanotic lesion. Intraocular pressure (IOP) was 40mmHg in RE. Gonioscopy revealed extension into the anterior chamber angle. Excisional biopsy was performed and consistent with iris melanoma and secondary melanomalytic glaucoma. Brachytherapy was performed as adjuvant therapy. DISCUSSION: In patients presenting with unilateral glaucoma and increased pigmentation in the trabecular meshwork, it is crucial to perform imaging studies...
October 13, 2016: Archivos de la Sociedad Española de Oftalmología
https://www.readbyqxmd.com/read/27745646/acral-melanoma-mimicking-subungual-hematoma
#14
Teresa Deinlein, Rainer Hofmann-Wellenhof, Iris Zalaudek
No abstract text is available yet for this article.
November 2016: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/27713771/iridociliary-melanoma-clinical-case
#15
S Schmitzer, C Butea-Simionescu, A Gheorghe, M Zemba, M Cioboata
Iris and ciliary body melanoma is an aggressive tumor, which, unfortunately, presents symptoms only in advanced stages and is often discovered accidentally during a routine eye examination. There are several treatment options, ranging from in time monitorization in order to observe the tumor's evolution to more aggressive methods such as radiotherapy and enucleation. We present a case of iridociliary melanoma, who underwent conservative surgery, iridocyclectomy under scleral flap, with good results, and maintenance of the function and integrity of the eyeball...
January 2016: Journal of Medicine and Life
https://www.readbyqxmd.com/read/27665123/amelanotic-iris-melanoma
#16
S Ajamil Rodanés, C García-Álvarez, M A Saornil Álvarez
No abstract text is available yet for this article.
September 21, 2016: Archivos de la Sociedad Española de Oftalmología
https://www.readbyqxmd.com/read/27622071/programmed-death-ligand-1-pd-l1-targeted-trail-combines-pd-l1-mediated-checkpoint-inhibition-with-trail-mediated-apoptosis-induction
#17
Djoke Hendriks, Yuan He, Iris Koopmans, Valerie R Wiersma, Robert J van Ginkel, Douwe F Samplonius, Wijnand Helfrich, Edwin Bremer
Antibodies that block PD-L1/PD-1 immune checkpoints restore the activity of functionally-impaired antitumor T cells. These antibodies show unprecedented clinical benefit in various advanced cancers, particularly in melanoma. However, only a subset of cancer patients responds to current PD-L1/PD-1-blocking strategies, highlighting the need for further advancements in PD-L1/PD-1-based immunotherapy. Here, we report on a novel approach designed to combine PD-L1 checkpoint inhibition with the tumor-selective induction of apoptosis by TNF-related Apoptosis Inducing Ligand (TRAIL)...
August 2016: Oncoimmunology
https://www.readbyqxmd.com/read/27580185/clinical-indications-for-use-of-reflectance-confocal-microscopy-for-skin-cancer-diagnosis
#18
Stefania Borsari, Riccardo Pampena, Aimilios Lallas, Athanassios Kyrgidis, Elvira Moscarella, Elisa Benati, Margherita Raucci, Giovanni Pellacani, Iris Zalaudek, Giuseppe Argenziano, Caterina Longo
Importance: Reflectance confocal microscopy (RCM) improves diagnostic accuracy in skin cancer detection when combined with dermoscopy; however, little evidence has been gathered regarding its real impact on routine clinical workflow, and, to our knowledge, no studies have defined the terms for its optimal application. Objective: To identify lesions on which RCM performs better in terms of diagnostic accuracy and consequently to outline the best indications for use of RCM...
October 1, 2016: JAMA Dermatology
https://www.readbyqxmd.com/read/27562393/management-and-outcome-of-uveal-melanoma-in-a-single-tertiary-cancer-center-in-jordan
#19
Ahmed Zewar, Ibrahim Nawaiseh, Imad Jaradat, Jakub Khzouz, Khaleel Alrawashdeh, Ghadeer Abdeen, Mustafa Mehyar, Samer Khurma, Yacoub A Yousef
OBJECTIVE: The aim of this study was evaluate the features and outcome of management of uveal melanoma in King Hussein Cancer Center as an example of a referral tertiary cancer center in the Middle East. MATERIAL AND METHOD: This was aetrospective, observational case series of 46 eyes of 46 patients with uveal melanoma. Data collection required access to medical records, radiology and pathology reports, and laboratory results. The main outcome measures included age at diagnosis, tumor location and dimensions, TNM stage, treatment modality, visual outcome, metastasis, and mortality...
2016: Türk Patoloji Dergisi
https://www.readbyqxmd.com/read/27548915/melanoma-mirna-trafficking-controls-tumour-primary-niche-formation
#20
Shani Dror, Laureen Sander, Hila Schwartz, Danna Sheinboim, Aviv Barzilai, Yuval Dishon, Sebastien Apcher, Tamar Golan, Shoshana Greenberger, Iris Barshack, Hagar Malcov, Alona Zilberberg, Lotan Levin, Michelle Nessling, Yael Friedmann, Vivien Igras, Ohad Barzilay, Hananya Vaknine, Ronen Brenner, Assaf Zinger, Avi Schroeder, Pinchas Gonen, Mehdi Khaled, Neta Erez, Jörg D Hoheisel, Carmit Levy
Melanoma originates in the epidermis and becomes metastatic after invasion into the dermis. Prior interactions between melanoma cells and dermis are poorly studied. Here, we show that melanoma cells directly affect the formation of the dermal tumour niche by microRNA trafficking before invasion. Melanocytes, cells of melanoma origin, are specialized in releasing pigment vesicles, termed melanosomes. In melanoma in situ, we found melanosome markers in distal fibroblasts before melanoma invasion. The melanosomes carry microRNAs into primary fibroblasts triggering changes, including increased proliferation, migration and pro-inflammatory gene expression, all known features of cancer-associated fibroblasts (CAFs)...
September 2016: Nature Cell Biology
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