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https://www.readbyqxmd.com/read/27911450/uveal-melanoma-relatively-rare-but-deadly-cancer
#1
REVIEW
S Kaliki, C L Shields
Although it is a relatively rare disease, primarily found in the Caucasian population, uveal melanoma is the most common primary intraocular tumor in adults with a mean age-adjusted incidence of 5.1 cases per million per year. Tumors are located either in iris (4%), ciliary body (6%), or choroid (90%). The host susceptibility factors for uveal melanoma include fair skin, light eye color, inability to tan, ocular or oculodermal melanocytosis, cutaneous or iris or choroidal nevus, and BRCA1-associated protein 1 mutation...
December 2, 2016: Eye
https://www.readbyqxmd.com/read/27879009/epidemiological-dermoscopical-and-pathological-evaluation-of-melanocytic-lesions-of-the-buttock-in-a-5-year-period-a-female-prevalence
#2
Giovanni Paolino, Iris Zalaudek, Anna Carbone, Pasquale Frascione, Michele Donati, Chiara Panetta, Pietro Donati
A self-assessment of the skin plays a pivotal role in the early diagnosis of melanoma. However, when pigmented lesions are located on hidden areas or on locations that are difficult to self-examine, their assessment becomes more difficult. This article is protected by copyright. All rights reserved.
November 23, 2016: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/27856029/optical-coherence-tomography-angiography-characteristics-of-iris-melanocytic-tumors
#3
Alison H Skalet, Yan Li, Chen D Lu, Yali Jia, ByungKun Lee, Lennart Husvogt, Andreas Maier, James G Fujimoto, Charles R Thomas, David Huang
PURPOSE: To evaluate tumor vasculature with optical coherence tomography angiography (OCTA) in malignant iris melanomas and benign iris lesions. DESIGN: Cross-sectional observational clinical study. PARTICIPANTS: Patients with iris lesions and healthy volunteers. METHODS: Eyes were imaged using OCTA systems operating at 1050- and 840-nm wavelengths. Three-dimensional OCTA scans were acquired. Iris melanoma patients treated with radiation therapy were imaged again after I-125 plaque brachytherapy at 6 and 18 months...
November 14, 2016: Ophthalmology
https://www.readbyqxmd.com/read/27821903/proteomic-approaches-to-biomarker-discovery-in-cutaneous-t-cell-lymphoma
#4
REVIEW
Alexandra Ion, Iris Maria Popa, Laura Maria Lucia Papagheorghe, Cristina Lisievici, Mihai Lupu, Vlad Voiculescu, Constantin Caruntu, Daniel Boda
Cutaneous T-cell lymphoma (CTCL) is the most frequently encountered type of skin lymphoma in humans. CTCL encompasses multiple variants, but the most common types are mycosis fungoides (MF) and Sezary syndrome (SS). While most cases of MF run a mild course over a period of many years, other subtypes of CTCL are very aggressive. The rapidly expanding fields of proteomics and genomics have not only helped increase knowledge concerning the carcinogenesis and tumor biology of CTCL but also led to the discovery of novel markers for targeted therapy...
2016: Disease Markers
https://www.readbyqxmd.com/read/27800275/uveal-melanoma-current-trends-in-diagnosis-and-management
#5
REVIEW
Berçin Tarlan, Hayyam Kıratlı
Uveal melanoma, which is the most common primary intraocular malignancy in adults, arises from melanocytes within the iris, ciliary body and choroid. The diagnosis is based principally on clinical examination of the tumor with biomicroscopy and indirect ophthalmoscopy and confirmed by diagnostic techniques such as ultrasonography, fundus fluorescein angiography and optical coherence tomography. The clinical diagnosis of posterior uveal melanomas can be made when the classical appearance of a pigmented dome-shaped mass is detected on dilated fundus exam...
June 2016: Turkish Journal of Ophthalmology
https://www.readbyqxmd.com/read/27790134/optical-coherence-tomography-angiography-of-iris-nevus-a-case-report
#6
Davide Allegrini, Giovanni Montesano, Alfredo Pece
Iris nevus is common: 6% of patients with suspected iris melanoma have lesions other than melanoma, and 36% of them are nevi. Iris nevus turns into melanoma in approximately 8% of cases at a mean of 15 years. This case report provides the first description of an iris tumor examined with iris optical coherence tomography angiography (OCTA) compared to iris fluorescein angiography (IFA). A 60-year-old man with a diagnosis of iris nevus in the left eye was referred to our department for IFA and iris OCTA. The iris vasculature in IFA was visible only in the early phases, but not clearly...
September 2016: Case Reports in Ophthalmology
https://www.readbyqxmd.com/read/27755196/limbal-stem-cell-preservation-during-proton-beam-irradiation-for-diffuse-iris-melanoma
#7
Arun D Singh, William J Dupps, Charles V Biscotti, John H Suh, Kira L Lathrop, John P Nairn, Helen Shih
PURPOSE: To report the outcome after limbal stem cell preservation during proton beam irradiation for diffuse iris melanoma. METHODS: This is a single-case report of diffuse iris melanoma that was managed with proton beam radiation (53 Gy), wherein preemptively harvested superior and inferior limbal stem cells before radiation were replaced after irradiation. Regeneration of the palisades of Vogt and the limbal stem cells was documented by an optical coherence tomography-based imaging protocol...
January 2017: Cornea
https://www.readbyqxmd.com/read/27746064/melanomalytic-glaucoma-secondary-to-iris-melanoma
#8
S Ajamil Rodanés, C García-Álvarez, M A Saornil Alvarez, F López-Lara, J M Frutos Baraja, M Quiñones
CLINICAL CASE: A 35-year-old male with unilateral ocular hypertension in the right eye (RE). Anterior segment examination of the RE showed a melanotic lesion. Intraocular pressure (IOP) was 40mmHg in RE. Gonioscopy revealed extension into the anterior chamber angle. Excisional biopsy was performed and consistent with iris melanoma and secondary melanomalytic glaucoma. Brachytherapy was performed as adjuvant therapy. DISCUSSION: In patients presenting with unilateral glaucoma and increased pigmentation in the trabecular meshwork, it is crucial to perform imaging studies...
October 13, 2016: Archivos de la Sociedad Española de Oftalmología
https://www.readbyqxmd.com/read/27745646/acral-melanoma-mimicking-subungual-hematoma
#9
Teresa Deinlein, Rainer Hofmann-Wellenhof, Iris Zalaudek
No abstract text is available yet for this article.
November 2016: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/27713771/iridociliary-melanoma-clinical-case
#10
S Schmitzer, C Butea-Simionescu, A Gheorghe, M Zemba, M Cioboata
Iris and ciliary body melanoma is an aggressive tumor, which, unfortunately, presents symptoms only in advanced stages and is often discovered accidentally during a routine eye examination. There are several treatment options, ranging from in time monitorization in order to observe the tumor's evolution to more aggressive methods such as radiotherapy and enucleation. We present a case of iridociliary melanoma, who underwent conservative surgery, iridocyclectomy under scleral flap, with good results, and maintenance of the function and integrity of the eyeball...
January 2016: Journal of Medicine and Life
https://www.readbyqxmd.com/read/27665123/amelanotic-iris-melanoma
#11
S Ajamil Rodanés, C García-Álvarez, M A Saornil Álvarez
No abstract text is available yet for this article.
September 21, 2016: Archivos de la Sociedad Española de Oftalmología
https://www.readbyqxmd.com/read/27622071/programmed-death-ligand-1-pd-l1-targeted-trail-combines-pd-l1-mediated-checkpoint-inhibition-with-trail-mediated-apoptosis-induction
#12
Djoke Hendriks, Yuan He, Iris Koopmans, Valerie R Wiersma, Robert J van Ginkel, Douwe F Samplonius, Wijnand Helfrich, Edwin Bremer
Antibodies that block PD-L1/PD-1 immune checkpoints restore the activity of functionally-impaired antitumor T cells. These antibodies show unprecedented clinical benefit in various advanced cancers, particularly in melanoma. However, only a subset of cancer patients responds to current PD-L1/PD-1-blocking strategies, highlighting the need for further advancements in PD-L1/PD-1-based immunotherapy. Here, we report on a novel approach designed to combine PD-L1 checkpoint inhibition with the tumor-selective induction of apoptosis by TNF-related Apoptosis Inducing Ligand (TRAIL)...
August 2016: Oncoimmunology
https://www.readbyqxmd.com/read/27580185/clinical-indications-for-use-of-reflectance-confocal-microscopy-for-skin-cancer-diagnosis
#13
Stefania Borsari, Riccardo Pampena, Aimilios Lallas, Athanassios Kyrgidis, Elvira Moscarella, Elisa Benati, Margherita Raucci, Giovanni Pellacani, Iris Zalaudek, Giuseppe Argenziano, Caterina Longo
Importance: Reflectance confocal microscopy (RCM) improves diagnostic accuracy in skin cancer detection when combined with dermoscopy; however, little evidence has been gathered regarding its real impact on routine clinical workflow, and, to our knowledge, no studies have defined the terms for its optimal application. Objective: To identify lesions on which RCM performs better in terms of diagnostic accuracy and consequently to outline the best indications for use of RCM...
October 1, 2016: JAMA Dermatology
https://www.readbyqxmd.com/read/27562393/management-and-outcome-of-uveal-melanoma-in-a-single-tertiary-cancer-center-in-jordan
#14
Ahmed Zewar, Ibrahim Nawaiseh, Imad Jaradat, Jakub Khzouz, Khaleel Alrawashdeh, Ghadeer Abdeen, Mustafa Mehyar, Samer Khurma, Yacoub A Yousef
OBJECTIVE: The aim of this study was evaluate the features and outcome of management of uveal melanoma in King Hussein Cancer Center as an example of a referral tertiary cancer center in the Middle East. MATERIAL AND METHOD: This was aetrospective, observational case series of 46 eyes of 46 patients with uveal melanoma. Data collection required access to medical records, radiology and pathology reports, and laboratory results. The main outcome measures included age at diagnosis, tumor location and dimensions, TNM stage, treatment modality, visual outcome, metastasis, and mortality...
2016: Türk Patoloji Dergisi
https://www.readbyqxmd.com/read/27548915/melanoma-mirna-trafficking-controls-tumour-primary-niche-formation
#15
Shani Dror, Laureen Sander, Hila Schwartz, Danna Sheinboim, Aviv Barzilai, Yuval Dishon, Sebastien Apcher, Tamar Golan, Shoshana Greenberger, Iris Barshack, Hagar Malcov, Alona Zilberberg, Lotan Levin, Michelle Nessling, Yael Friedmann, Vivien Igras, Ohad Barzilay, Hananya Vaknine, Ronen Brenner, Assaf Zinger, Avi Schroeder, Pinchas Gonen, Mehdi Khaled, Neta Erez, Jörg D Hoheisel, Carmit Levy
Melanoma originates in the epidermis and becomes metastatic after invasion into the dermis. Prior interactions between melanoma cells and dermis are poorly studied. Here, we show that melanoma cells directly affect the formation of the dermal tumour niche by microRNA trafficking before invasion. Melanocytes, cells of melanoma origin, are specialized in releasing pigment vesicles, termed melanosomes. In melanoma in situ, we found melanosome markers in distal fibroblasts before melanoma invasion. The melanosomes carry microRNAs into primary fibroblasts triggering changes, including increased proliferation, migration and pro-inflammatory gene expression, all known features of cancer-associated fibroblasts (CAFs)...
September 2016: Nature Cell Biology
https://www.readbyqxmd.com/read/27546281/adam-10-expression-in-primary-uveal-melanoma-as-prognostic-factor-for-risk-of-metastasis
#16
Rosario Caltabiano, Lidia Puzzo, Valeria Barresi, Antonio Ieni, Carla Loreto, Giuseppe Musumeci, Paola Castrogiovanni, Marco Ragusa, Pietro Foti, Andrea Russo, Antonio Longo, Michele Reibaldi
Uveal melanoma is the most frequent primary intraocular neoplasm in adults. Although malignant melanoma may be located at any point in the uveal tract, the choroid and ciliary body are more frequent locations than the iris. In the present study, we examined ADAM10 expression levels in primary uveal melanoma both with and without metastasis, and we evaluated their association with other high risk characteristics for metastasis in order to assess if ADAM10 can be used to predict metastasis. This study included a total of 52 patients, 23 men and 29 women, with uveal melanoma...
November 2016: Pathology, Research and Practice
https://www.readbyqxmd.com/read/27525433/tumor-immune-profiling-predicts-response-to-anti-pd-1-therapy-in-human-melanoma
#17
Adil I Daud, Kimberly Loo, Mariela L Pauli, Robert Sanchez-Rodriguez, Priscila Munoz Sandoval, Keyon Taravati, Katy Tsai, Adi Nosrati, Lorenzo Nardo, Michael D Alvarado, Alain P Algazi, Miguel H Pampaloni, Iryna V Lobach, Jimmy Hwang, Robert H Pierce, Iris K Gratz, Matthew F Krummel, Michael D Rosenblum
BACKGROUND: Immune checkpoint blockade is revolutionizing therapy for advanced cancer, but many patients do not respond to treatment. The identification of robust biomarkers that predict clinical response to specific checkpoint inhibitors is critical in order to stratify patients and to rationally select combinations in the context of an expanding array of therapeutic options. METHODS: We performed multiparameter flow cytometry on freshly isolated metastatic melanoma samples from 2 cohorts of 20 patients each prior to treatment and correlated the subsequent clinical response with the tumor immune phenotype...
September 1, 2016: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/27486750/risk-factors-and-relationship-of-cutaneous-and-uveal-melanocytic-lesions-in-monozygotic-and-dizygotic-twin-pairs
#18
Renáta Zsanett Csoma, Edit Tóth-Molnár, Anita Varga, Hajnalka Szabó, Hajnalka Orvos, Lajos Kemény, Judit Oláh
BACKGROUND: The similar genetic background of a pair of twins, and the similar environmental impacts to which they are exposed allow an exact and objective investigation of various constitutional and environmental factors in naevus development. As far as we are aware, this is the first published survey that simultaneously examines cutaneous and ocular pigmented lesions in an appreciable sample of identical and non-identical twins. METHODS: 172 pairs of twins of Caucasian origin were included in this study...
2016: PloS One
https://www.readbyqxmd.com/read/27424159/a-first-in-human-phase-i-study-to-evaluate-the-mek1-2-inhibitor-cobimetinib-administered-daily-in-patients-with-advanced-solid-tumors
#19
Lee S Rosen, Patricia LoRusso, Wen Wee Ma, Jonathan W Goldman, Amy Weise, A Dimitrios Colevas, Alex Adjei, Salim Yazji, Angela Shen, Stuart Johnston, Hsin-Ju Hsieh, Iris T Chan, Branimir I Sikic
Objective Cobimetinib, a MEK1/2 inhibitor, was administered to patients with advanced solid tumors to assess safety, pharmacokinetics, pharmacodynamics, and anti-tumor activity. Methods For dose-escalation, a 3 + 3 design was used. Oral cobimetinib was administered once daily on a 21-day on/7-day off (21/7) or a 14-day on/14-day off (14/14) schedule. Serial plasma samples were collected for pharmacokinetic (PK) analysis on Day 1 and at steady state. In expansion stages, patients with RAS or RAF mutant tumors were treated at the maximum tolerated dose (MTD) of the 21/7 or 14/14 schedule...
October 2016: Investigational New Drugs
https://www.readbyqxmd.com/read/27409496/enhanced-depth-imaging-optical-coherence-tomography-of-the-human-choroid-in-vivo-compared-with-histology-after-enucleation
#20
Xiao Qiang Li, Steffen Heegaard, Jens Folke Kiilgaard, Inger Christine Munch, Michael Larsen
PURPOSE: This study compared in vivo enhanced-depth imaging optical coherence tomography (EDI-OCT) with ex vivo histology of the choroid in human eyes. METHODS: Three eyes in three patients with advanced iris melanoma without posterior segment involvement underwent EDI-OCT less than 24 hours prior to enucleation and, in one eye, immediately after enucleation. Following fixation in 4% buffered formaldehyde and paraffin embedding, serial sections of the whole eye were cut horizontally, mounted, stained with hematoxylin-eosin and digitized...
July 1, 2016: Investigative Ophthalmology & Visual Science
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