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Iris melanoma

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https://www.readbyqxmd.com/read/29315480/iris-pigmented-lesions-as-a-marker-of-cutaneous-melanoma-risk-an-australian-case-control-study
#1
A M Laino, E G Berry, K Jagirdar, K J Lee, D L Duffy, H P Soyer, R A Sturm
BACKGROUND: Iris naevi and iris freckles have a frequency of 4% and 50% in the European population. They are associated with dysplastic naevi, but few studies examine their link to cutaneous melanoma. OBJECTIVES: To assess whether iris pigmented lesions are a predictive indicator for cutaneous melanoma. METHODS: This is a melanoma case-control study of 1254 European-background Australians. Sun exposure and melanoma history, a saliva sample for DNA analysis, and eye photographs taken with a digital camera were collected from 1117 participants...
January 8, 2018: British Journal of Dermatology
https://www.readbyqxmd.com/read/29311509/7-azaindole-a-versatile-scaffold-for-developing-kinase-inhibitors
#2
Takayuki Irie, Masaaki Sawa
The majority of kinase inhibitors have been developed as ATP competitors to interact with a hinge region in ATP binding sites of kinases. 7-Azaindole has been found as an excellent hinge binding motif by making two hydrogen bonds with the kinase hinge region. Vemurafenib, a B-RAF kinase (serine-threonine kinase [STK]) inhibitor approved by the U.S. Food and Drug Administration (FDA) for the treatment of melanoma, was created from this simple 7-azaindole fragment by successful use of structure-based drug design techniques...
2018: Chemical & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/29287164/cyclooxygenase-2-expression-in-the-eyes-of-cats-with-and-without-uveitis
#3
Zhi Hui Sim, Chantale L Pinard, Brandon L Plattner, Dorothee Bienzle
OBJECTIVE To characterize the distribution and intensity of cyclooxygenase (COX)-2 expression in the eyes of cats with and without uveitis and to determine whether COX-2 expression is correlated with severity of inflammation. SAMPLES Archived ocular tissue specimens from 51 cats with and 10 cats without ocular disease. PROCEDURES Specimens from only 1 eye were evaluated for each cat. Specimens were stained with H&E stain or immunohistochemical stain for detection of COX-2 and reviewed. For each eye, the type, severity, and distribution of inflammation and the distribution and intensity of COX-2 expression were determined for the uvea and other ocular tissues...
January 2018: American Journal of Veterinary Research
https://www.readbyqxmd.com/read/29245925/histopathological-expression-analysis-of-intercellular-adhesion-molecule-1-icam-1-along-development-and-progression-of-human-melanoma
#4
Gilli Galore-Haskel, Erez N Baruch, Amy L Berg, Iris Barshack, Itzhak Zilinsky, Camila Avivi, Michal J Besser, Jacob Schachter, Gal Markel
Intercellular adhesion molecule 1 (ICAM-1) protein is an important adhesion molecule that facilitates metastasis on one hand, and on the other hand supports the immunological synapse necessary for T-cell mediated elimination. The expression pattern of ICAM-1 in melanoma was studied more than two decades ago, mainly in cell lines or in unmatched melanoma specimens. By using real time PCR we could not demonstrate a clear difference in ICAM-1 mRNA levels between primary melanocytes and primary cultures of metastatic melanoma...
November 21, 2017: Oncotarget
https://www.readbyqxmd.com/read/29226425/intraventricular-melanocytoma-diagnosis-confirmed-by-gene-mutation-profile
#5
Ulrich J Knappe, Iris Tischoff, Andrea Tannapfel, Wolf-Dieter Reinbold, Inga Möller, Antje Sucker, Dirk Schadendorf, Klaus G Griewank, Johannes A P van de Nes
Primary leptomeningeal melanocytic tumors (PLMTs) are rare. They usually arise along the spinal cord and at the skull base. Here we report on a patient with a very rare intraventricular melanocytoma. Histologically, a melanocytic tumor was clearly diagnosed. However, to make the uncommon diagnosis of an intraventricular melanocytoma, metastatic melanoma needed to be excluded. Next generation sequencing covering gene mutations that may occur in PLMTs and cutaneous melanoma was performed. The unique gene mutation profile detected, consisting of an activating CYSLTR2 L129Q mutation and EIF1AX G9R mutation and a lack of mutations in genes known to occur in metastatic melanoma (i...
December 11, 2017: Neuropathology: Official Journal of the Japanese Society of Neuropathology
https://www.readbyqxmd.com/read/29214112/hypomelanotic-melanoma-detected-by-the-little-red-riding-hood-sign-in-a-patient-with-neurofibromatosis-type-1
#6
Roberta Giuffrida, Maximilian Uranitsch, Karin Schmid, Teresa Deinlein, Fabrizio Favero, Iris Zalaudek
Neurofibromatosis type 1 (NF1) is a genetic disorder commonly associated with an increased risk for development of malignancy, including skin cancers. Herein we describe a case of invasive melanoma occurring in a patient with NF1 and discuss the association between these two diseases, highlighting the importance of comparative clinical and dermoscopic approaches in this category of patients in which the detection of melanoma can be difficult because of the presence of multiple skin tumors.
October 2017: Dermatology Practical & Conceptual
https://www.readbyqxmd.com/read/29156467/-diagnosis-and-therapy-of-iris-lesions
#7
Joel M Mor, Konrad R Koch, Ludwig M Heindl
The most common iris lesions are iris nevi, iris melanomas and iris pigment epithelium cysts. However, there is an abundance of rare differential diagnoses that have to be considered, including other melanocytic and non-melanocytic lesions. Diagnostic tools include the slit lamp examination, gonioscopy, tonometry, transillumination, ultrasound biomicroscopy (UBM), optical coherence tomography, fluorescein angiography and standardized photography-assisted documentation. The timely identification of malignant lesions (i...
November 20, 2017: Klinische Monatsblätter Für Augenheilkunde
https://www.readbyqxmd.com/read/29150959/nono-ubiquitination-is-mediated-by-fbw7-and-gsk3-%C3%AE-via-a-degron-lost-upon-chromosomal-rearrangement-in-cancer
#8
Luigi Alfano, Antonella Caporaso, Angela Altieri, Caterina Costa, Iris M Forte, Carmelina A Iannuzzi, Daniela Barone, Luca Esposito, Antonio Giordano, Francesca Pentimalli
NONO is an RNA-binding protein involved in transcription, mRNA splicing, DNA repair and checkpoint activation in response to UV radiation. NONO expression has been found altered in several tumour types, including prostate, colon, breast, melanoma and in papillary renal carcinoma, in which an X chromosome inversion generates a NONO-TFE3 fusion protein. Upon such rearrangement, NONO loses its C-terminal domain. Through bioinformatics analysis, we identified a putative degron motif, known to be recognized by the Skp1-Cul1-F-box-protein (SCF) complex...
November 18, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29135712/limbal-stem-cell-preservation-during-proton-beam-irradiation-for-diffuse-iris-melanoma
#9
Paul T Finger, Wolfgang A G Sauerwein
No abstract text is available yet for this article.
November 13, 2017: Cornea
https://www.readbyqxmd.com/read/29128229/proton-beam-therapy-for-iris-melanomas-in-107-patients
#10
Juliette Thariat, Ahmed Rahmi, Julia Salleron, Carlo Mosci, Benjamin Butet, Celia Maschi, Francesco Lanza, Sara Lanteri, Stephanie Baillif, Joel Herault, Thibaud Mathis, Jean Pierre Caujolle
PURPOSE: To report on the clinical characteristics and outcomes for patients with iris melanoma using proton therapy. DESIGN: Retrospective study. PARTICIPANTS: One hundred seven patients with iris melanoma from 3 regional ophthalmologic centers. METHODS: A retrospective study was conducted for iris melanoma patients from 3 regional ophthalmologic centers referred to and treated at a single proton therapy facility between 1996 and 2015...
November 8, 2017: Ophthalmology
https://www.readbyqxmd.com/read/29122824/ruthenium-106-brachytherapy-for-iris-and-iridociliary-melanomas
#11
Marina Marinkovic, Nanda Horeweg, Mirjam S Laman, Jaco C Bleeker, Martijn Ketelaars, Femke P Peters, Gre P M Luyten, Carien L Creutzberg
BACKGROUND AND PURPOSE: To evaluate ruthenium-106 (Ru106) brachytherapy as eye-conserving treatment of iris melanomas (IMs) and iridociliary melanomas (ICMs). MATERIALS AND METHODS: Eighty-eight patients received Ru106 brachytherapy between 2006 and 2016. Primary outcome was local control, and secondary outcomes were metastasis, survival, eye preservation, complications and visual acuity (VA). RESULTS: Overall median follow-up was 36 months...
November 9, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/29082081/human-iris-three-dimensional-imaging-at-micron-resolution-by-a-micro-plenoptic-camera
#12
Hao Chen, Maria A Woodward, David T Burke, V Swetha E Jeganathan, Hakan Demirci, Volker Sick
A micro-plenoptic system was designed to capture the three-dimensional (3D) topography of the anterior iris surface by simple single-shot imaging. Within a depth-of-field of 2.4 mm, depth resolution of 10 µm can be achieved with accuracy (systematic errors) and precision (random errors) below 20%. We demonstrated the application of our micro-plenoptic imaging system on two healthy irides, an iris with naevi, and an iris with melanoma. The ridges and folds, with height differences of 10~80 µm, on the healthy irides can be effectively captured...
October 1, 2017: Biomedical Optics Express
https://www.readbyqxmd.com/read/29042650/handheld-photoacoustic-microscopy-probe
#13
Kyungjin Park, Jin Young Kim, Changho Lee, Seungwan Jeon, Geunbae Lim, Chulhong Kim
Optical resolution photoacoustic microscopy (OR-PAM) is a non-invasive, label-free method of in vivo imaging with microscopic resolution and high optical contrast. Based on intrinsic contrasts, OR-PAM has expanded to include in vivo vessel imaging, flow cytometry, physiological parameter analysis, and single-cell characterization. However, since conventional OR-PAM systems have a fixed tabletop configuration, a large system size, and slow imaging speed, their use in preclinical and clinical studies remains limited...
October 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29038913/-ocular-melanomas-an-update
#14
REVIEW
H Kalirai, P L Müller, D Jaehne, S E Coupland
Melanoma is the most common type of primary cancer to affect the adult eye. Approximately 95% of ocular melanomas are intraocular and arise from the uvea (i. e. iris, ciliary body, and choroid), while the remaining 5% are located in the conjunctiva. Although both uveal and conjunctival melanomas are thought to derive from malignantly transformed melanocytes, uveal melanoma is clinically and biologically distinct from conjunctival melanoma, and indeed from its more common cutaneous counterpart. Intense efforts have been recently made to understand the molecular biology involved in the development of ocular melanomas, and in their progression...
November 2017: Der Pathologe
https://www.readbyqxmd.com/read/28971066/clinical-and-research-activities-at-the-catana-facility-of-infn-lns-from-the-conventional-hadrontherapy-to-the-laser-driven-approach
#15
Giuseppe A P Cirrone, Giacomo Cuttone, Luigi Raffaele, Vincenzo Salamone, Teresio Avitabile, Giuseppe Privitera, Corrado Spatola, Daniele Margarone, Valeria Patti, Giada Petringa, Francesco Romano, Andrea Russo, Antonio Russo, Maria G Sabini, Valentina Scuderi, Francesco Schillaci, Lucia M Valastro
The CATANA proton therapy center was the first Italian clinical facility making use of energetic (62 MeV) proton beams for the radioactive treatment of solid tumors. Since the date of the first patient treatment in 2002, 294 patients have been successful treated whose majority was affected by choroidal and iris melanomas. In this paper, we report on the current clinical and physical status of the CATANA facility describing the last dosimetric studies and reporting on the last patient follow-up results. The last part of the paper is dedicated to the description of the INFN-LNS ongoing activities on the realization of a beamline for the transport of laser-accelerated ion beams for future applications...
2017: Frontiers in Oncology
https://www.readbyqxmd.com/read/28937525/choroidal-melanoma-in-phakomatosis-pigmentovascularis-with-klippel-trenaunay-syndrome
#16
Carol L Shields, Maura Di Nicola, Marco Pellegrini, Jerry A Shields
PURPOSE: To describe the relationship of choroidal melanoma with phakomatosis pigmentovascularis in patients with Klippel-Trenaunay syndrome. METHODS: Retrospective review of 5 patients. RESULTS: In all 5 cases, the patient was white and the cutaneous port-wine stain was congenital. The port-wine stain involved the chin (n = 1), jawline (n = 2), lower cheek (n = 1), thorax (n = 5), abdomen (n = 4), upper (n = 4), and lower (n = 3) limb(s)...
September 20, 2017: Retina
https://www.readbyqxmd.com/read/28882848/orbital-recurrence-of-iris-melanoma-21-years-after-enucleation
#17
Emilie Bergeron, Nadia Lihimdi, Dan Bergeron, Solange Landreville
We present the case of a 56-year-old man who developed a neoplasm of epithelioid histology in his anophthalmic left orbit 21 years after he underwent enucleation for a spindle cell iris melanoma. The recurrent tumour was managed by orbital exenteration. Neither further recurrence nor metastasis was diagnosed over a 5-year follow-up period. This case, along with five other similar cases in the literature,(1-3) emphasises the importance of long-term follow-up after treatment of iris melanoma.
September 7, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28868012/treatment-of-primary-and-metastatic-multifocal-mucosal-melanoma-of-the-oral-cavity-with-imatinib
#18
Teresa Deinlein, Ingrid H Wolf, Barbara Rainer, Romana Kupsa, Erika Richtig, Rainer Hofmann-Wellenhof, Iris Zalaudek
BACKGROUND: Mucosal melanoma of the oral cavity is a rare entity and accounts for less than 1-3% of all melanomas. Contrary to cutaneous melanoma, primary oral melanoma more commonly harbors mutations in c-KIT. METHODS: A 64-year-old man presented with asymptomatic, multiple, brown-to-black macules in the oral cavity. A biopsy was taken and histopathology exhibited mucosal melanoma. In molecular analysis, a c-KIT mutation was proven and a CT scan revealed pulmonary metastases...
May 2017: Case Reports in Oncology
https://www.readbyqxmd.com/read/28845329/evaluation-of-iris-melanoma-with-anterior-segment-optical-coherence-tomography
#19
Mehtap Arslantürk Eren, Ahmet Kaan Gündüz, Özlenen Ömür Gündüz
Anterior segment optical coherence tomography (AS-OCT) is a relatively new imaging modality that allows assessment of anterior segment structures. AS-OCT enables the differentiation of benign and malignant tumors through the evaluation of lesion size, internal structure, degree of vascularity, and anterior and posterior surfaces. Herein, we discuss the AS-OCT findings of a patient with spindle type iridociliary melanoma diagnosed in pathologic examination.
August 2017: Turkish Journal of Ophthalmology
https://www.readbyqxmd.com/read/28844752/multifocal-iris-melanoma-in-a-2-year-old-managed-with-i-125-plaque-brachytherapy
#20
Andrew R Lee, Dilraj S Grewal, Thomas J Cummings, Laura B Enyedi, Nicole A Larrier, Prithvi Mruthyunjaya
We report a 23-month-old patient presenting with multifocal iris melanoma who underwent plaque brachytherapy with full corneal coverage. The lesion demonstrated several high-risk clinical and histopathologic features associated with iris melanoma in adults, including growth and angle seeding. The patient has been subsequently followed for 3.5 years with no evidence of recurrence. This report demonstrates the importance of serial examination of suspected melanocytic iris lesions in very young children and the effective treatment option of globe-sparing radiation therapy...
August 26, 2017: Journal of AAPOS: the Official Publication of the American Association for Pediatric Ophthalmology and Strabismus
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