Anna Giménez-Palomo, Mariona Guitart-Mampel, Gemma Roqué, Ester Sánchez, Roger Borràs, Ana Meseguer, Francesc Josep García-García, Esther Tobías, Laura Valls-Roca, Gerard Anmella, Marc Valentí, Luis Olivier, Oscar de Juan, Iñaki Ochandiano, Helena Andreu, Joaquim Radua, Norma Verdolini, Michael Berk, Eduard Vieta, Glòria Garrabou, Josep Roca, Xavier Alsina-Restoy, Isabella Pacchiarotti
BACKGROUND: Aerobic capacity has shown to predict physical and mental health-related quality of life in bipolar disorder (BD). However, the correlation between exercise respiratory capacity and mitochondrial function remains understudied. We aimed to assess longitudinally intra-individual differences in these factors during mood episodes and remission in BD. METHODS: This study included eight BD patients admitted to an acute psychiatric unit. Incremental cardiopulmonary exercise test (CPET) was conducted during acute episodes (T0), followed by constant work rate cycle ergometry (CWRCE) to evaluate endurance time, oxygen uptake at peak exercise (VO2peak ) and at the anaerobic threshold...
2024: Frontiers in Psychiatry