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Breast-Q reduction

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https://www.readbyqxmd.com/read/27453120/-discussion-of-breast-cancer-screening-model-in-china
#1
W Q Li, R Li, P F Liu, Y B Huang
Cancer screening has been considered as double-edged sword with both advantages and disadvantages. For decades, there have been strong interests in screening strategies for the early detection of cancers to reduce the mortality, especially breast X-ray(mammography)screening. However, several evidences also suggested that the benefit of reduction of breast-cancer mortality with mammography might become a problem due to the repeat mammography, subsequent biopsies, and overdiagnosis. And different screening strategies with different models, different intervals, and different target populations also incurred debates...
July 2016: Zhonghua Liu Xing Bing Xue za Zhi, Zhonghua Liuxingbingxue Zazhi
https://www.readbyqxmd.com/read/27393183/patient-satisfaction-with-nipple-sparing-mastectomy-a-prospective-study-of-patient-reported-outcomes-using-the-breast-q
#2
Michael A Howard, Mark Sisco, Katharine Yao, David J Winchester, Ermilo Barrera, Jeremy Warner, Jennifer Jaffe, Peter Hulick, Kristine Kuchta, Andrea L Pusic, Stephen F Sener
BACKGROUND AND OBJECTIVES: The authors sought to study patient-reported outcomes following nipple-sparing mastectomy (NSM). METHODS: From 2008 to 2011, the BREAST-Q was administered to women undergoing NSM surgery for cancer treatment or risk-reduction prior to surgery and at 2 years after completion of reconstruction. The change in score over time and the impact of surgical indication, complication occurrence, and laterality on scores were analyzed. RESULTS: The BREAST-Q was prospectively administered to 39 women undergoing NSM for cancer treatment (n = 17) or risk-reduction (RR) (n = 22)...
September 2016: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/27312036/clinical-outcome-and-patient-satisfaction-with-the-use-of-bovine-derived-acellular-dermal-matrix-surgimend%C3%A2-in-implant-based-immediate-reconstruction-following-skin-sparing-mastectomy-a-prospective-observational-study-in-a-single-centre
#3
REVIEW
Hannah Headon, Abdul Kasem, Aisling Manson, Christina Choy, Amtul R Carmichael, Kefah Mokbel
INTRODUCTION: The advent of acellular dermal matrix devices (ADMs) has enhanced both the scope of implant-based immediate breast reconstruction (IBR) following skin sparing mastectomy (SSM) for the treatment or risk reduction of breast cancer. Currently, there are a wide range of options available for the use of ADMs. METHODS: This is a prospective observational single institution study of 118 consecutive patients undergoing a total of 164 SSM and IBR procedures either for treatment for breast cancer or for risk reduction, between 2012 and 2014...
June 2016: Surgical Oncology
https://www.readbyqxmd.com/read/27179527/development-of-a-japanese-version-of-the-breast-q-and-the-traditional-psychometric-test-of-the-mastectomy-module-for-the-assessment-of-hrqol-and-patient-satisfaction-following-breast-surgery
#4
Miho Saiga, Naruto Taira, Yoshihiro Kimata, Satoko Watanabe, Yuko Mukai, Kojiro Shimozuma, Taeko Mizoo, Tomohiro Nogami, Takayuki Iwamoto, Takayuki Motoki, Tadahiko Shien, Junji Matsuoka, Hiroyoshi Doihara
BACKGROUND: An understanding of health-related quality of life (HRQOL) is of utmost importance in both oncological and esthetic breast surgery. The BREAST-Q is a patient-reported outcome (PRO) measure that investigates HRQOL and patient satisfaction before and after breast surgery. The aim of this study was to develop a Japanese version of the BREAST-Q including the mastectomy module, the reconstruction module, the augmentation module and the reduction/mastopexy module, and to assess the psychometric properties of the mastectomy module among Japanese women...
May 14, 2016: Breast Cancer: the Journal of the Japanese Breast Cancer Society
https://www.readbyqxmd.com/read/27146156/addition-of-vasopressin-synthetic-analogue-v-4-q-5-ddavp-to-standard-chemotherapy-enhances-tumour-growth-inhibition-and-impairs-metastatic-spread-in-aggressive-breast-tumour-models
#5
Juan Garona, Marina Pifano, Maria B Pastrian, Daniel E Gomez, Giselle V Ripoll, Daniel F Alonso
[V(4)Q(5)]dDAVP is a novel 2nd generation vasopressin analogue with robust antitumour activity against metastatic breast cancer. We recently reported that, by acting on vasopressin V2r membrane receptor present in tumour cells and microvascular endothelium, [V(4)Q(5)]dDAVP inhibits angiogenesis and metastatic progression of the disease without overt toxicity. Despite chemotherapy remaining as a primary therapeutic option for aggressive breast cancer, its use is limited by low selectivity and associated adverse effects...
August 2016: Clinical & Experimental Metastasis
https://www.readbyqxmd.com/read/27065661/patient-reported-outcomes-following-breast-reconstruction-surgery-and-therapeutic-mammoplasty-prospective-evaluation-1%C3%A2-year-post-surgery-with-breast-q-questionnaire
#6
Laxmi Shekhawat, Laleh Busheri, Santosh Dixit, Chaula Patel, Upendra Dhar, Chaitanyanand Koppiker
Breast Cancer (BC) treatment leads to mutilation and destruction of breast shape with negative effects on body image and self-esteem.One of the main goals of reconstructive and oncoplastic breast surgery is to satisfy patients and improve their quality of life (QoL).Therefore, it is important to assess the patient experience post-surgery by means of patient-reported outcome measures (PROMs) that focus on the patient's perception of the surgery and surgical care, as well as psychosocial well-being and physical functioning...
December 2015: Indian Journal of Surgical Oncology
https://www.readbyqxmd.com/read/26906351/vertical-sculpted-pillar-reduction-mammaplasty-in-317-patients-technique-complications-and-breast-q-outcomes
#7
Brian M Derby, James C Grotting, David T Redden
BACKGROUND: The senior author (JCG) has described the vertical sculpted pillar breast reduction. OBJECTIVES: This manuscript aimed to compare this technique's safety profile to other established techniques via complication rate reporting. Few studies have utilized the BREAST-Q for long-term outcomes reporting in bilateral reduction mammaplasty patients. BREAST-Q outcome comparisons, between cosmetic and insurance-based breast reduction cohorts, have not been previously reported...
April 2016: Aesthetic Surgery Journal
https://www.readbyqxmd.com/read/26906129/beliefs-in-chemotherapy-and-knowledge-of-cancer-and-treatment-among-african-american-women-with-newly-diagnosed-breast-cancer
#8
Yun Jiang, Susan M Sereika, Catherine M Bender, Adam M Brufsky, Margaret Q Rosenzweig
PURPOSE/OBJECTIVES: To examine beliefs regarding the necessity of chemotherapy and knowledge of breast cancer and its treatment in African American women with newly diagnosed breast cancer, and to explore factors associated with women's beliefs and knowledge.
. DESIGN: Descriptive, cross-sectional study.
. SETTING: Six urban cancer centers in Western Pennsylvania and Eastern Ohio.
. SAMPLE: 101 African American women with newly diagnosed breast cancer...
March 2016: Oncology Nursing Forum
https://www.readbyqxmd.com/read/26866274/structural-simulation-of-adenosine-phosphate-via-plumbagin-and-zoledronic-acid-competitively-targets-jnk-erk-to-synergistically-attenuate-osteoclastogenesis-in-a-breast-cancer-model
#9
H Qiao, T-y Wang, Z-f Yu, X-g Han, X-q Liu, Y-g Wang, Q-m Fan, A Qin, T-t Tang
The treatment of breast cancer-induced osteolysis remains a challenge in clinical settings. Here, we explored the effect and mechanism of combined treatment with zoledronic acid (ZA) and plumbagin (PL), a widely investigated component derived from Plumbago zeylanica, against breast cancer-induced osteoclastogenesis. We found that the combined treatment with PL and ZA suppressed cell viability of precursor osteoclasts and synergistically inhibited MDA-MB-231-induced osteoclast formation (combination index=0...
2016: Cell Death & Disease
https://www.readbyqxmd.com/read/26819650/does-time-affect-patient-satisfaction-and-health-related-quality-of-life-after-reduction-mammoplasty
#10
Wess A Cohen, Peter Homel, Nima P Patel
OBJECTIVE: A total of 62,611 patients with breast hypertrophy underwent breast reduction surgery in 2013 in the United States to improve their symptoms and health-related quality of life. While multiple studies utilizing various outcome instruments demonstrate the efficacy of reductive surgery, it is presently unknown how the postoperative course affects patient satisfaction and health-related quality of life as measured by the BREAST-Q. Our objective was to determine the temporal relationship of patient satisfaction and health-related quality of life after reduction mammoplasty...
2016: Eplasty
https://www.readbyqxmd.com/read/26367579/jitter-reduction-technique-for-acoustic-radiation-force-impulse-microscopy-via-photoacoustic-detection
#11
Bong Jin Kang, Changhan Yoon, Jin Man Park, Jae Youn Hwang, K Kirk Shung
We demonstrate a jitter noise reduction technique for acoustic radiation force impulse microscopy via photoacoustic detection (PA-ARFI), which promises to be capable of measuring cell mechanics. To reduce the jitter noise induced by Q-switched pulsed laser operated at high repetition frequency, photoacoustic signals from the surface of an ultrasound transducer are aligned by cross-correlation and peak-to-peak detection, respectively. Each method is then employed to measure the displacements of a target sample in an agar phantom and a breast cancer cell due to ARFI application, followed by the quantitative comparison between their performances...
July 27, 2015: Optics Express
https://www.readbyqxmd.com/read/26321231/the-adhesion-g-protein-coupled-receptor-g2-adgrg2-gpr64-constitutively-activates-sre-and-nf%C3%AE%C2%BAb-and-is-involved-in-cell-adhesion-and-migration
#12
Miriam C Peeters, Michiel Fokkelman, Bob Boogaard, Kristoffer L Egerod, Bob van de Water, Ad P IJzerman, Thue W Schwartz
Adhesion G protein-coupled receptors (ADGRs) are believed to be activated by auto-proteolytic cleavage of their very large extracellular N-terminal domains normally acting as a negative regulator of the intrinsically constitutively active seven transmembrane domain. ADGRG2 (or GPR64) which originally was described to be expressed in the epididymis and studied for its potential role in male fertility, is highly up-regulated in a number of carcinomas, including breast cancer. Here, we demonstrate that ADGRG2 is a functional receptor, which in transfected HEK293 cells signals with constitutive activity through the adhesion- and migration-related transcription factors serum response element (SRE) and nuclear factor kappa-light-chain-enhancer of activated B cells (NFκB) presumably via coupling to Gα12/13 and Gαq...
December 2015: Cellular Signalling
https://www.readbyqxmd.com/read/26319120/candidate-early-detection-protein-biomarkers-for-er-pr-invasive-ductal-breast-carcinoma-identified-using-pre-clinical-plasma-from-the-whi-observational-study
#13
Matthew F Buas, Jung-hyun Rho, Xiaoyu Chai, Yuzheng Zhang, Paul D Lampe, Christopher I Li
Estrogen receptor (ER)-positive/progesterone receptor (PR)-positive invasive ductal carcinoma accounts for ~45 % of invasive breast cancer (BC) diagnoses in the U.S. Despite reductions in BC mortality attributable to mammography screening and adjuvant hormonal therapy, an important challenge remains the development of clinically useful blood-based biomarkers for risk assessment and early detection. The objective of this study was to identify novel protein markers for ER+/PR+ ductal BC. A nested case-control study was conducted within the Women's Health Initiative observational study...
September 2015: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/26278137/association-of-bcsc-1-with-human-esophageal-squamous-cell-carcinoma
#14
C L Zhao, W J Yu, Z Q Gao, W T Li, W Gao, W W Yang, W G Feng, J Y Ju
Breast cancer suppressor candidate-1 (BCSC-1) is a newly identified candidate tumor suppressor gene. BCSC-1 shows decreased levels in a variety of cancer types. In this study, we investigated the association between BCSC-1 and human esophageal squamous cell carcinoma (ESCC). BCSC-1 expression was detected in ESCC and normal tissues adjacent to tumor tissues by Western blot analysis and real-time PCR  as well as immunohistochemistry of paraffin sections. The relationships between BCSC-1 expression and various clinicopathological characteristics were analyzed...
2015: Neoplasma
https://www.readbyqxmd.com/read/26192233/bisindole-pbd-regulates-breast-cancer-cell-proliferation-via-sirt-p53-axis
#15
Pranjal Sarma, Indira Bag, M Janaki Ramaiah, Ahmed Kamal, Utpal Bhadra, Manika Pal Bhadra
In a previous study we reported the role of potent bisindole-PBD conjugate as an inclusion in the arsenal of breast cancer therapeutics. In breast cancer cell proliferation, PI3K/AKT/mTOR pathway plays a crucial role by prosurvival mechanism that inhibits programmed cell death. Here, 2 breast cancer cells lines, MCF-7 and MDA-MB-231 were treated with Vorinostat (suberoylanilide hydroxamic acid / SAHA) and bisindole-PBD (5b). We have investigated the effect on PI3K/AKT/mTOR pathway and SIRT expression including epigenetic regulation...
2015: Cancer Biology & Therapy
https://www.readbyqxmd.com/read/26125274/hsa-mir-206-represses-the-proliferation-and-invasion-of-breast-cancer-cells-by-targeting-cx43
#16
Y Fu, Z-M Shao, Q-Z He, B-Q Jiang, Y Wu, Z-G Zhuang
OBJECTIVE: Hsa-miR-206, a microRNA, was found to be able to switch subtypes by targeting ER-α in breast cancer. However, there are few studies addressing the role of miR-206 in triple-negative breast cancer (TNBC). The purpose of this study was to evaluate the metastatic-regulatory ability of miR-206 in TNBC. MATERIALS AND METHODS: We treated two TNBC lines (MDA-MB-231 and MDA-MB-436) with miR-206 mimics, inhibitors and paired controls and examined the in vitro and in vivo functions of miR-206 via the degradation of Connexin43 (Cx43)...
2015: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/26117780/curcumin-reduced-graphene-oxide-sheets-and-their-effects-on-human-breast-cancer-cells
#17
Shadie Hatamie, Omid Akhavan, Sayed Khatiboleslam Sadrnezhaad, Mohammad Mahdi Ahadian, Mandar M Shirolkar, Haiqian Q Wang
Curcumin (as a natural reductant material) was utilized for green reduction and functionalization of chemically exfoliated graphene oxide (GO) sheets. The π-π attachment of the curcumin molecules onto the curcumin-reduced graphene oxide (rGO) sheets was confirmed by Raman and Fourier transform infrared spectroscopies. Zeta potential of the GO sheets decreased from about -40 mV to -20 mV, after the green reduction and functionalization. The probable cytotoxicity of the curcumin-rGO sheets was studied through their interactions with two human breast cancer cell lines (MDA-MB-231 and SKBR3 cell lines) and a normal cell line (mouse fibroblast L929 cell line)...
October 2015: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/26076217/patient-satisfaction-and-nipple-areola-sensitivity-after-bilateral-prophylactic-mastectomy-and-immediate-implant-breast-reconstruction-in-a-high-breast-cancer-risk-population-nipple-sparing-mastectomy-versus-skin-sparing-mastectomy
#18
Victorien M T van Verschuer, Marc A M Mureau, Jessica P Gopie, Elvira L Vos, Cornelis Verhoef, Marian B E Menke-Pluijmers, Linetta B Koppert
BACKGROUND: Prophylactic skin-sparing mastectomy (SSM) and nipple-sparing mastectomy (NSM) both are associated with major risk reduction in women with high breast cancer risk. Skin-sparing mastectomy followed by nipple-areola complex (NAC) reconstruction is standard of care, but NSM is increasingly being performed. Preservation of the NAC in NSM may increase patient satisfaction. Therefore, we measured NAC sensitivity after NSM and compared patient satisfaction as well as body image after SSM with NSM...
August 2016: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/26017612/the-use-of-reduction-mammaplasty-with-breast-conservation-therapy-an-analysis-of-timing-and-outcomes
#19
COMPARATIVE STUDY
Francesco M Egro, Ximena Pinell-White, Alexandra Marie Hart, Albert Losken
BACKGROUND: Oncoplastic reduction mammaplasty is often used to prevent or correct breast conservation therapy deformities. The purpose of this review was to evaluate surgical outcomes, patient satisfaction, and aesthetic outcomes of this procedure when performed before or after radiation therapy. METHODS: Breast cancer patients treated with breast conservation therapy and reduction mammaplasty between 2005 and 2012 were divided into immediate reconstruction, delayed immediate reconstruction, and delayed reconstruction...
June 2015: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/25997967/impact-of-the-21-gene-recurrence-score-assay-in-adjuvant-chemotherapy-selection-for-node-negative-hormone-receptor-positive-breast-cancer-in-the-chinese-population
#20
Y N Zhang, Y D Zhou, F Mao, Q Sun
The 21-Gene Recurrence Score Assay has been intensively studied and recommended by major guidelines for treatment decision in early breast cancer. Its impact in adjuvant chemotherapy selection for Chinese population has not been revealed.The prospective part of this study enrolled consecutive node-negative, hormone receptor-positive patients who underwent 21-gene RS testing at Breast Surgery Department of PUMCH (n=134) between May 2012 and August 2013(21-gene RS group). Risk categories were assigned based on the RS and on standard clinicopathologic criteria according to St...
2015: Neoplasma
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