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https://www.readbyqxmd.com/read/29787758/tissue-factor-mediates-microvesicles-shedding-from-mda-mb-231-breast-cancer-cells
#1
Araci M da R Rondon, Vitor H de Almeida, Tainá Gomes, Bruno R F Verçoza, Renato S Carvalho, Sandra König, Juliany C F Rodrigues, Claudia Dos S Mermelstein, Henri H Versteeg, Robson Q Monteiro
Extracellular vesicles, such as microvesicles (MVs), were identified as important players in tumor progression and acquisition of an aggressive phenotype. Tissue factor (TF) is a transmembrane protein that initiates the blood coagulation cascade. In tumor cells, TF has been associated with aggressiveness and cancer progression. Previous studies demonstrate that TF is incorporated into MVs secreted by tumor cells; however, it is unknown whether TF is actively involved in the release of MVs. Here, we investigated the influence of TF expression on the release of MVs...
May 19, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29747311/-study-of-bioequiavailability-of-paclitaxel-for-injection-albumin-bound-and-abraxane-and-the-efficacy-of-extension-treatments-in-patients-with-metastatic-breast-cancer
#2
L Bian, C Z Geng, Q C Ouyang, X C Hu, Y Y Peng, J Y Xiao, M X Wang, N Yang, J Yuan, Y M Wang, Z F Jiang
Objective: To compare the bioequiavailability of paclitaxel for injection (albumin bound) (PAB) and reference listed drug abraxane in the patients with metastatic breast cancer, and to investigate the safety and efficacy in the extension treatments of PAB. Methods: This study was random, two cycles, self-crossover control study in the bioequiavailability stage. PAB was the investigational drug T and Abraxane was the reference drug R. Patients were randomly assigned to two cycles therapy of either R→T or T→R(260 mg/m(2)/21d)...
April 24, 2018: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/29617707/changes-in-body-mass-index-and-physical-activity-predict-changes-in-vitality-during-a-weight-loss-trial-in-breast-cancer-survivors
#3
Kelly M Kenzik, Wendy Demark-Wahnefried, Patricia A Ganz, Graham Colditz, Cheryl L Rock, Laura Q Rogers
Background: Breast cancer survivors rank fatigue (e.g., decreased vitality) as their number one concern affecting quality of life. Excess adiposity is associated with decreased vitality in breast cancer survivors, yet weight loss intervention trials report inconsistent effects on this parameter. Methods: This is a secondary analysis of the Exercise and Nutrition to Enhance Recovery and Good Health for You trial, in which 692 overweight or obese breast cancer survivors ≤5 years from diagnosis, initiated weight loss interventions, and completed assessments semi-annually for 2 years...
March 29, 2018: Annals of Behavioral Medicine: a Publication of the Society of Behavioral Medicine
https://www.readbyqxmd.com/read/29575835/-the-therapeutic-effect-of-hsv1-hgm-csf-combined-with-doxorubicin-on-the-mouse-breast-cancer-model
#4
X F Zhuang, S R Zhang, B L Liu, J L Wu, X Q Li, H G Gu, Y Shu
Objective: To evaluate the oncolytic effect of herpes simplex virus type 1 which carried recombined human granulocyte-macrophage colony-stimulating factor (HSV1-hGM-CSF) on the mouse breast cancer cell line 4T1 and compare the anticancer effects of HSV1-hGM-CSF, doxorubicin alone or combination on the breast cancer in mice. Methods: We investigated the cytotoxic effect on 4T1 cells in vitro, the cell growth, cell apoptosis and cell cycle of 4T1 cells treated with oncolytic HSV1-hGM-CSF at different MOIs (0, 0...
March 23, 2018: Zhonghua Zhong Liu za Zhi [Chinese Journal of Oncology]
https://www.readbyqxmd.com/read/29565204/zno-q-dots-as-a-potent-therapeutic-nanomedicine-for-in-vitro-cytotoxicity-evaluation-of-mouth-kb44-breast-mcf7-colon-ht29-and-hela-cancer-cell-lines-mouse-ear-swelling-tests-in-vivo-and-its-side-effects-using-the-animal-model
#5
Zahra Fakhroueian, Rouhollah Vahabpour, Mehdi Assmar, Alireza Massiha, Afshin Zahedi, Pegah Esmaeilzadeh, Fatemeh Katouzian, Sara Rezaei, Peyman Keyhanvar, Alireza Mozafari Dehshiri
Nanoformulations derived from fine porous ZnO quantum dot nanoparticles (QD NPs) can offer strong potential medical applications; especially in cancer therapy. ZnO QD NPs was synthesized by sol-gel hydrothermal process, fast cold quenching and further smart surface functionalization methods to obtain ultrasmall size (1-4 nm) NPs. ZnO nanopolymer, a wetting agent, PEG co-solvent and water/oil emulsion stabilizer were considered in our nanofluid formulation. The resulting nanofluid was characterized by SEM, FTIR, photoluminescence, band gap energy, zeta potential and UV-Vis spectroscopy...
March 22, 2018: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/29443834/does-2-stage-implant-based-breast-reconstruction-allow-for-a-larger-volume-of-the-definite-implant-compared-with-1-stage-reconstruction
#6
R C Killaars, J Hommes, R R van der Hulst, H J Tielemans, V L Negenborn, A Piatkowski
INTRODUCTION: Breast reconstruction using implants is still the main breast reconstruction technique worldwide. Current debate within implant-based breast reconstruction is whether to perform a 1-stage (direct implant) or 2-stage (tissue expander/implant) reconstruction. Volume differences between a woman's native breast and changes in volume after breast reconstruction might be an important factor for a patient's choice between these types of reconstruction. Three-dimensional imaging facilitates objective breast volume estimates...
May 2018: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/29422399/quality-of-life-improvement-after-chest-wall-masculinization-in-female-to-male-transgender-patients-a-prospective-study-using-the-breast-q-and-body-uneasiness-test
#7
Cori A Agarwal, Melody F Scheefer, Lindsey N Wright, Norelle K Walzer, Andy Rivera
BACKGROUND: Chest reconstruction in many female-to-male (FTM) transgender individuals is an essential element of treatment for their gender dysphoria. In existing literature, there are very few longitudinal studies utilizing validated survey tools to evaluate patient reported outcomes surrounding this surgery. The purpose of our study is to prospectively evaluate patient reported satisfaction, improvement in body image, and quality of life following FTM chest wall reconstruction. METHODS: Our study was a prospective analysis of FTM patients who underwent chest reconstruction by a single surgeon (C...
May 2018: Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS
https://www.readbyqxmd.com/read/29420367/early-response-assessed-by-contrast-enhanced-ultrasound-in-breast-cancer-patients-undergoing-neoadjuvant-chemotherapy
#8
Ting Dong
The study was aimed to investigate the role of contrast-enhanced ultrasound (CEUS) in evaluating the response of patients with breast cancer after receiving neoadjuvant chemotherapy (NAC). A systematic search was conducted in PubMed, Spring, Wanfang, and CNKI databases from 1923 to December 2016. Based on fixed effect model or randomized effects model, standardized mean difference (SMD) with its 95% confidence interval (95% CI) was calculated in accordance with heterogeneity analysis. Cochran Q and I tests were used to measure heterogeneity...
February 7, 2018: Ultrasound Quarterly
https://www.readbyqxmd.com/read/29359234/analysis-of-symmetry-stability-following-implant-based-breast-reconstruction-and-contralateral-management-in-582-patients-with-long-term-outcomes
#9
M Barone, A Cogliandro, M Signoretti, P Persichetti
INTRODUCTION: This study aimed to analyse the long-term outcomes following breast reconstruction and contralateral management to evaluate the stability of breast symmetry and patient satisfaction. MATERIALS AND METHODS: The study population consisted of women who had undergone implant-based monolateral breast reconstruction and contralateral management. Patients answered the BREAST-Q reconstruction module. Two reviewers analysed the post-operative outcomes of the patients included and compiled the Kroll Scale...
January 22, 2018: Aesthetic Plastic Surgery
https://www.readbyqxmd.com/read/29353883/growth-arrest-and-apoptosis-induction-in-androgen-receptor-positive-human-breast-cancer-cells-by-inhibition-of-usp14-mediated-androgen-receptor-deubiquitination
#10
Yuning Liao, Xiaohong Xia, Ningning Liu, Jianyu Cai, Zhiqiang Guo, Yanling Li, Lili Jiang, Q Ping Dou, Daolin Tang, Hongbiao Huang, Jinbao Liu
It has been well known that androgen receptor (AR) is critical to prostate cancer development and progression. It has also been documented that AR is expressed in more than 60% of breast tumors, which promotes the growth of estrogen receptor-negative (ER- )/AR-positive (AR+ ) breast cancer cells. Thus, AR might be a potential therapeutic target for AR-positive/ER-negative breast cancer patients. Previously we reported that in prostate cancer cells proteasome-associated deubiquitinase ubiquitin-specific protease 14 (USP14) stabilized AR protein level by removing its ubiquitin chain...
April 2018: Oncogene
https://www.readbyqxmd.com/read/29124379/use-of-the-breast-q%C3%A2-survey-in-the-prospective-evaluation-of-reduction-mammaplasty-outcomes
#11
Isaias Vieira Cabral, Edgard da Silva Garcia, Rebecca Neponucena Sobrinho, Natália Lana Larcher Pinto, Yara Juliano, Joel Veiga-Filho, Lydia Masako Ferreira, Daniela Francescato Veiga
INTRODUCTION: BREAST-Q™ is a patient-reported outcomes survey instrument with a specific module that evaluates breast reduction surgery. It allows assessment of patient's satisfaction with received treatment and evaluates the impact of surgery on different aspects of the patient's quality of life. This article aims to assess the satisfaction and quality of life of patients who underwent reduction mammaplasty. MATERIALS AND METHODS: Women aged between 18 and 60 years, with a body mass index ranging from 19 to 30 kg/m2 , who were already scheduled for reduction mammaplasty, were included in the study...
April 2018: Aesthetic Plastic Surgery
https://www.readbyqxmd.com/read/29069857/a-phase-i-study-of-the-src-kinase-inhibitor-dasatinib-with-trastuzumab-and-paclitaxel-as-first-line-therapy-for-patients-with-her2-overexpressing-advanced-breast-cancer-geicam-2010-04-study
#12
Alberto Ocana, Marta Gil-Martin, Miguel Martín, Federico Rojo, Silvia Antolín, Ángel Guerrero, José Manuel Trigo, Montse Muñoz, Atanasio Pandiella, Núria Gonzalo Diego, Susana Bezares, Rosalía Caballero, Eva Carrasco, Ander Urruticoechea
The anti-HER2 antibody trastuzumab have shown clinical activity in combination with chemotherapy in different breast cancer settings. However, most of patients treated with this antibody progress after a period of treatment. Activation of the kinase SRC has been linked with resistance to trastuzumab in several preclinical studies. We designed a phase I clinical study to explore the activity of weekly trastuzumab (2 mg/kg) plus paclitaxel (80 mg/m2 ) in combination with the anti-SRC kinase inhibitor Dasatinib in the first line treatment of HER2 metastatic breast cancer...
September 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/28958831/no-direct-correlation-between-rotavirus-diarrhea-and-breast-feeding-a-meta-analysis
#13
Jian Shen, Bi-Meng Zhang, Sheng-Guo Zhu, Jian-Jie Chen
BACKGROUND: Some studies indicated that children with exclusive breast feeding had a reduction in the prevalence of rotavirus diarrhea, while some others held the opposite views. In this study, we aimed to systematically find the associations between rotavirus diarrhea and breast feeding. METHODS: A literature search up to June 2016 in electronic literature databases, including PubMed and Embase, was performed. The Newcastle-Ottawa Scale was used to conduct the quality assessment of all the selected studies...
August 26, 2017: Pediatrics and Neonatology
https://www.readbyqxmd.com/read/28865492/pathobiology-of-the-129-stat1-mouse-model-of-human-age-related-er-positive-breast-cancer-with-an-immune-infiltrate-excluded-phenotype
#14
Hidetoshi Mori, Jane Q Chen, Robert D Cardiff, Zsófia Pénzváltó, Neil E Hubbard, Louis Schuetter, Russell C Hovey, Josephine F Trott, Alexander D Borowsky
BACKGROUND: Stat1 gene-targeted knockout mice (129S6/SvEvTac-Stat1 (tm1Rds)) develop estrogen receptor-positive (ER(+)), luminal-type mammary carcinomas at an advanced age. There is evidence for both host environment as well as tumor cell-intrinsic mechanisms to initiate tumorigenesis in this model. In this report, we summarize details of the systemic and mammary pathology at preneoplastic and tumor-bearing time points. In addition, we investigate tumor progression in the 129:Stat1 (-/-) host compared with wild-type 129/SvEv, and we describe the immune cell reaction to the tumors...
September 2, 2017: Breast Cancer Research: BCR
https://www.readbyqxmd.com/read/28835084/-a-multicenter-clinical-study-for-the-comparison-of-s-1-versus-capecitabine-in-the-treatment-of-advanced-breast-cancer
#15
Y Li, D Jiang, Y Y Wu, L L Li, Y Z Cui, Q Dong
Objective: To investigate the safety, efficacy and prognostic factors of S-1 versus capecitabine in patients with advanced breast cancer (ABC). Methods: From January 1, 2012 to December 31, 2014, 154 ABC patients with pathological diagnosis were separated into two groups: S-1 with or without the 3rd generation chemotherapy drug (group S-1) and capecitabine with or without the 3rd generation chemotherapy drug (Group capecitabine). The efficacy, side effects and prognostic factors were compared between the two groups...
August 23, 2017: Zhonghua Zhong Liu za Zhi [Chinese Journal of Oncology]
https://www.readbyqxmd.com/read/28819836/management-of-contralateral-breast-following-mastectomy-and-breast-reconstruction-using-a-mirror-adjustment-with-crescent-mastopexy-technique
#16
A Cogliandro, B Brunetti, Mauro Barone, G Favia, P Persichetti
INTRODUCTION: Heterologous breast reconstruction after mastectomy sometimes requires the management of the contralateral breast to achieve symmetric long lasting aesthetic results. Some techniques could be used for the symmetrization of contralateral breast with or without implants as breast augmentation, reduction mammoplasty, mastopexy, with T inverted, J, vertical, periareolar, semi-circular, or axillary scars. The aim of this study is to present the use of crescent mastopexy technique with implants in contralateral adjustment following monolateral breast reconstruction compared with a control group in which patients underwent other contralateral procedures...
January 2018: Breast Cancer: the Journal of the Japanese Breast Cancer Society
https://www.readbyqxmd.com/read/28810293/-comparative-study-of-three-different-decalcifying-solutions-in-bone-metastasis-specimens-with-breast-cancer
#17
H Y Wu, T Wang, K L Chen, Z W Fan, X H Pu, B Zhang, X S Fan, F Q Meng
Objective: To investigate the optimal strategy for immunohistochemical (IHC) staining in bone metastasis specimens from breast cancer. Methods: Twenty-eight bone metastases specimens from breast cancers were divided into three groups and subjected to different decalcifying agents (group A-10% nitrate, group B-EDTA decalcification, and group C-imported decalcifying solution RapidCal). The effects of those on HE and IHC staining for Ki-67, ER, PR, GATA3, RANK, RANKL, HER2 and HER2 FISH results were assessed. Results: There were no significant differences among three groups in HE morphology and IHC staining...
August 8, 2017: Zhonghua Bing Li Xue za Zhi Chinese Journal of Pathology
https://www.readbyqxmd.com/read/28760362/the-addition-of-automated-breast-ultrasound-to-mammography-in-breast-cancer-screening-decreases-stage-at-diagnosis
#18
Ian Grady, Nailya Chanisheva, Tony Vasquez
RATIONALE AND OBJECTIVES: This study aimed to determine the best screening strategy using automated whole-breast ultrasound and mammography in women with increased breast density or an elevated risk of breast cancer. MATERIALS AND METHODS: After an institutional review board waiver was obtained, a retrospective review of 122 cancer cases diagnosed in 3435 women with increased breast density or an elevated risk of breast cancer, screened with mammography and supplemental automated whole-breast ultrasound, was performed...
December 2017: Academic Radiology
https://www.readbyqxmd.com/read/28742207/socs3-overexpression-enhances-adm-resistance-in-bladder-cancer-t24-cells
#19
M-Z Li, D-H Lai, H-B Zhao, Z Chen, Q-X Huang, J Situ
OBJECTIVE: JAK-STAT3 signaling pathway widely participates in cell proliferation and apoptosis. Suppressor of cytokine signaling 3 (SOCS3) is a negative regulator of JAK-STAT3. SOCS3 downregulation is associated with drug resistance in breast cancer and leukemia. However, its role in bladder cancer drug resistance is still unclear. This study established ADM resistant bladder cancer cell model to investigate the role of SOCS3-JAK/STAT3 signaling pathway ADM resistance. MATERIALS AND METHODS: ADM drug resistant cell line T24/ADM was established...
July 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28694766/flavoenzyme-mediated-reduction-reactions-and-antitumor-activity-of-nitrogen-containing-tetracyclic-ortho-quinone-compounds-and-their-nitrated-derivatives
#20
Milda Peciukaityte-Alksne, Jonas Šarlauskas, Lina Miseviciene, Audrone Maroziene, Narimantas Cenas, Kastis Krikštopaitis, Zita Staniulyte, Žilvinas Anusevicius
Nitrogen-based tetracyclic ortho-quinones (naphtho[1'2':4.5]imidazo[1,2-a]pyridine-5,6-diones, NPDOs) and their nitro-substituted derivatives (nitro-(P)NPDOs) were obtained by condensation of substituted 2,3-dichloro-1,4-naphthoquinones with 2-amino-pyridine and -pyrimidine and nitration at an elevated temperature. The structural features of the compounds as well as their global and regional electrophilic potency were characterized by means of DFT computation. The compounds were highly reactive substrates of single- and two-electron (hydride) - transferring P-450R (CPR; EC 1...
2017: EXCLI Journal
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