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Free light chains

Yue Yang, Long Chen, Yuan Jia, Yang Liu, Lei Wen, Yaoxian Liang, Yuan An, Shi Chen, Yin Su, Zhanguo Li
To analyze the clinical spectrum, laboratory characteristics, and outcomes of monoclonal gammopathy (MG) in patients with rheumatic diseases. Screening for the presence of MG was performed in 872 inpatients with rheumatic diseases from January 2010 to July 2017. A total of 41 patients were enrolled. Their clinical and biological features in addition to outcomes were described. For each patient with primary Sjögren syndrome (pSS), 2 age- and sex-matched pSS patients without MG were selected as controls. Risk factors for the presence of MG and malignant hematological neoplasias were assessed...
March 13, 2018: Clinical Rheumatology
Jianfeng Sun, Peng Li, Lei Guo, Fang Yu, Yu-Peng He, Lingling Chu
The group transfer radical addition of olefins with tosyl cyanide has been accomplished via visible light-induced organophotoredox catalysis. A diverse array of olefins is amenable to this protocol, furnishing β-sulfonyl nitriles with excellent efficiency under metal-free and redox-neutral conditions. A closed catalytic cycle is operative in this transformation, providing complementary reactivity to the classic radical chain process.
March 12, 2018: Chemical Communications: Chem Comm
Yannick P Borguet, Sarosh Khan, Amandine Noel, Sean P Gunsten, Steven L Brody, Mahmoud Elsabahy, Karen L Wooley
To expand the range of functional polymer materials to include fully hydrolytically degradable systems that bear bioinspired phosphorus-containing linkages both along the backbone and as cationic side chain moieties for packaging and delivery of nucleic acids, phosphonium-functionalized polyphosphoester- block-poly(l-lactide) copolymers of various compositions were synthesized, fully characterized, and their self-assembly into nanoparticles were studied. First, an alkyne-functionalized polyphosphoester- block-poly(l-lactide) copolymer was synthesized via a one pot sequential ring opening polymerization of an alkyne-functionalized phospholane monomer, followed by the addition of l-lactide to grow the second block...
March 11, 2018: Biomacromolecules
Miriam Steinberg, Joseph P Gaut, Stanley Paul Hmiel, Aadil Kakajiwala
Monoclonal gammopathies are a rare diagnosis in pediatric patients. A 19-year-old female patient with past medical history of hypogammaglobulinemia and natural killer cell deficiency and stage III follicular lymphoma, in remission, presented with a right-sided pneumonia, noted to have acute kidney injury and proteinuria. Complement C3 and C4 levels were normal. Anti-double-stranded DNA antibodies, antinuclear antibodies, anti-extractable nuclear antigen antibodies, and antineutrophil cytoplasmic antibodies were negative...
March 9, 2018: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
Ignacio Martín-Fabiani, Jennifer Lesage de la Haye, Malin Schulz, Yang Liu, Michelle Lee, Brendan Duffy, Franck D'Agosto, Muriel Lansalot, Joseph L Keddie
The presence of low molar mass surfactants in latex films results in detrimental effects on their water permeability, gloss and adhesion. For applications as coatings, there is a need to develop formulations that do not contain surfactants and that have better water barrier properties. Having previously reported the synthesis of surfactant-free latex particles in water using low amounts (< 2 wt%) of controlled radical polymer chains (Lesage de la Haye et al. Macromolecules 2017, 50, 9315-9328), here we study the water barrier properties of films made from these particles and their application in anti-corrosion coatings...
March 8, 2018: ACS Applied Materials & Interfaces
Min Jeong Kim, Joo Hui Kim, Il Young Kim, Soo Bong Lee, In Seong Park, Mi Yeun Han, Harin Rhee, Sang Heon Song, Eun Young Seong, Ihm Soo Kwak, Dong Won Lee
Preeclampsia is the most common cause of proteinuria with hypertension during pregnancy. Primary kidney disease and kidney disease secondary to systemic disorders may rarely occur during pregnancy, resulting in proteinuria. A 34-year-old woman was admitted to our hospital with abdominal distention and lower extremity edema. The pregnancy was terminated at the 24th week of gestation due to preterm labor. Even after the delivery, proteinuria and renal deterioration continued to progress. The M-peak was not found on serum and urine protein electrophoresis...
March 2018: Iranian Journal of Kidney Diseases
Georgia C Boles, Randy L Hightower, Rebecca A Coates, Christopher P McNary, Giel Berden, Jos Oomens, Peter B Armentrout
Complexes of aspartic acid (Asp) cationized with Zn2+: Zn(Asp H)+, Zn(Asp H)+(ACN) where ACN = acetonitrile, and Zn(Asp H)+(Asp), as well as with Cd2+, CdCl+(Asp), were examined by infrared multiple photon dissociation (IRMPD) action spectroscopy using light generated from a free electron laser. A series of low-energy conformers for each complex was found using quantum chemical calculations in order to identify the structures formed experimentally. The main binding motif observed for the heavy metal complex, CdCl+(Asp)[N,CO,COs], is a charge solvated, tridentate structure where the metal center binds to the backbone amino group and carbonyl oxygens of the backbone and side-chain carboxylic acids...
March 4, 2018: Journal of Physical Chemistry. B
Elham Abdelmonem Mohamed, Irhan Ibrahim Abu Hashim, Rehab Mohammad Yusif, Ahmed Abdel Aziz Shaaban, Ahmed Ramadan El-Sheakh, Mohammed Fawzy Hamed, Farid Abd Elreheem Badria
Naringin is one of the most interesting phytopharmaceuticals that has been widely investigated for various biological actions. Yet, its low water solubility, limited permeability, and suboptimal bioavailability limited its use. Therefore, in this study, polymeric micelles of naringin based on pluronic F68 (PF68) were developed, fully characterized, and optimized. The optimized formula was investigated regarding in vitro release, storage stability, and in vitro cytotoxicity vs different cell lines. Also, cytoprotection against ethanol-induced ulcer in rats and antitumor activity against Ehrlich ascites carcinoma in mice were investigated...
2018: International Journal of Nanomedicine
David Zeman
No abstract text is available yet for this article.
March 1, 2018: Clinical Chemistry and Laboratory Medicine: CCLM
Vesselina Goranova-Marinova, Marianna Yaneva, Tanya Deneva, Stefan Goranov, Dubravka Mužina Mišić
There is a small but well recognized group of patients with multiple myeloma (MM), characterized by multiple bone lesions and low tumor burden, the so-called macrofocal form of MM (MF-MM). The aim of the study was to analyze the incidence, clinical manifestation, therapeutic outcome and prognosis of patients with MF-MM treated with bortezomib-based therapy and radiotherapy, in comparison to classic MM. There were 148 MM patients treated with bortezomibbased regimens, with 15 (10.1%) of them meeting the criteria for MF-MM...
June 2017: Acta Clinica Croatica
Surbhi Sidana, Nidhi Tandon, Angela Dispenzieri, Morie A Gertz, David Dingli, Dragan Jevremovic, William G Morice, Prashant Kapoor, Taxiarchis V Kourelis, Martha Q Lacy, Suzanne R Hayman, Francis K Buadi, Nelson Leung, Ronald S Go, Yi Lin, Stephen J Russell, John A Lust, Steven R Zeldenrust, Rahma Warsame, Yi L Hwa, Miriam Hobbs, Amie Fonder, Robert A Kyle, S Vincent Rajkumar, Shaji K Kumar, Wilson I Gonsalves
We evaluated the prognostic impact of clonal circulating plasma cells (cPCs) detected by six-color multi-parametric flow cytometry (MFC) in light chain (AL) amyloidosis at diagnosis. Of the 154 patients who underwent MFC, cPCs were detected in 42% (n = 65) patients. Median number of cPCs was 81 per 150,000 events (range: 6-17,844). High bone marrow plasma cell percentage was an independent predictor of presence of cPCs. Presence of cPCs at diagnosis was associated with inferior overall survival (OS) (90 vs...
February 21, 2018: Leukemia: Official Journal of the Leukemia Society of America, Leukemia Research Fund, U.K
Natalia Tovar, Luis Gerardo Rodríguez-Lobato, Maria Teresa Cibeira, Laura Magnano, Ignacio Isola, Laura Rosiñol, Joan Bladé, Carlos Fernández de Larrea
OBJECTIVES: Prognosis of immunoglobulin light-chain (AL) amyloidosis depends mainly on the presence of cardiac involvement and the disease burden. A higher bone marrow plasma cell (BMPC) burden has been recognized as an adverse prognostic factor. The aim of our study was to analyze the correlation between the BMPC infiltration, clinical features and outcomes in patients with AL amyloidosis. METHODS: The clinical records of 79 patients with AL amyloidosis treated at a single institution...
February 26, 2018: Amyloid: the International Journal of Experimental and Clinical Investigation
Kanji Miyazaki, Kenshi Suzuki
BACKGROUND: Heavy/light chain (HLC) assay can quantify involved as well as uninvolved immunoglobulin pairs and is used to detect monoclonal proteins. PATIENTS AND METHODS: We compared the sensitivity between HLC assay and serum protein electrophoresis, serum immunofixation electrophoresis (IFE), and free light chain (FLC) assay in patients with symptomatic multiple myeloma (n = 111) whose responses were stable disease or better. RESULTS: Among patients with negative IFE and normal FLC ratios, 84...
February 19, 2018: Clinical Lymphoma, Myeloma & Leukemia
Yann Molard, Malo Robin, Noée Dumait, Maria Amela-Cortes, Claire Roiland, Maxime Harnois, Emmanuel Jacques, Hervé Folliot
Hybrid nanomaterials made of inorganic nanocomponents dispersed in an organic host raise an increasing interest as low-cost solution-processable functional materials. However, preventing phase segregation while allowing a high inorganic doping content remains a major challenge, and usual methods require a functionalization step prior integration. Herein, we report a new approach to design such nanocomposite in which lead-free and cadmium-free ceramic-like metallic nanocluster compounds are embedded at 10 wt % in organic copolymers, without any functionalization...
February 22, 2018: Chemistry: a European Journal
Kari M Gurtner, Eslam Shosha, Sandra C Bryant, Bruna D Andreguetto, David L Murray, Sean J Pittock, Maria Alice V Willrich
BACKGROUND: Cerebrospinal fluid (CSF) used in immunoglobulin gamma (IgG) index testing and oligoclonal bands (OCBs) are common laboratory tests used in the diagnosis of multiple sclerosis. The measurement of CSF free light chains (FLC) could pose as an alternative to the labor-intensive isoelectric-focusing (IEF) gels used for OCBs. METHODS: A total of 325 residual paired CSF and serum specimens were obtained after physician-ordered OCB IEF testing. CSF kappa (cKFLC) and lambda FLC (cLFLC), albumin and total IgG were measured...
February 19, 2018: Clinical Chemistry and Laboratory Medicine: CCLM
Yoann Cote, Patrice Delarue, Harold Abraham Scheraga, Patrick Senet, Gia G Maisuradze
α-synuclein (αS) is a major constituent of Lewy bodies, the insoluble aggregates that are the hallmark of one of the most prevalent neurodegenerative disorders - Parkinson's disease (PD). The vast majority of experiments in vitro and in vivo provide extensive evidence that a disordered monomeric form is the predominant state of αS in water solution, and it undergoes a large-scale disorder-to-helix transition upon binding to vesicles of different types. Recently, another form, tetrameric, of αS with a stable helical structure was identified experimentally...
February 16, 2018: ACS Chemical Neuroscience
Silvia Bosello, Umberto Basile, Enrico De Lorenzis, Francesca Gulli, Giovanni Canestrari, Cecilia Napodano, Federico Parisi, Krizia Pocino, Clara Di Mario, Barbara Tolusso, Gianfranco Ferraccioli, Elisa Gremese
AIM: Humoral immunity and B cells are thought to play an important role in the pathophysiology of the systemic sclerosis (SSc). The production of free light chains (FLC) of immunoglobulins is abnormally high in several pathological autoimmune conditions and reflects B cell activation. Furthermore, FLCs demonstrated different biological activities including their capability to modulate the immune system, proteolytic activity and complement cascade activation. The aims of this study are to determine the FLC levels in patients with SSc compared with healthy controls (HC) and to study their possible association with organ involvement and disease characteristics...
January 31, 2018: Journal of Clinical Pathology
S Huang, M Podgórski, X Zhang, J Sinha, M Claudino, J W Stansbury, C N Bowman
Step-growth thiol-Michael photopolymerizable resins, constituting an alternative chemistry to the current methacrylate-based chain-growth polymerizations, were developed and evaluated for use as dental restorative materials. The beneficial features inherent to anion-mediated thiol-Michael polymerizations were explored, such as rapid photocuring, low stress generation, ester content tunability, and improved mechanical performance in a moist environment. An ester-free tetrafunctional thiol and a ultraviolet-sensitive photobase generator were implemented to facilitate thiol-Michael photopolymerization...
February 1, 2018: Journal of Dental Research
Makan Khoshnejad, Colin Fred Greineder, Katherine W Pulsipher, Carlos H Villa, Burcin Altun, Daniel C Pan, Andrew Tsourkas, Ivan J Dmochowski, Vladimir Muzykantov
Genetic incorporation of biologically orthogonal functional groups into macromolecules has the potential to yield efficient, controlled, reproducible, site-specific conjugation of affinity ligands, contrast agents, or therapeutic cargoes. Here, we applied this approach to ferritin, a ubiquitous iron-storage protein that self-assembles into multimeric nanocages with remarkable stability, size uniformity (12 nm), and endogenous capacity for loading and transport of a variety of inorganic and organic cargoes. The unnatural amino acid, 4-azidophenylalanine (4-AzF), was incorporated at different sites in the human ferritin light chain (hFTL) to allow site-specific conjugation of alkyne-containing small molecules or affinity ligands to the exterior surface of the nanocage...
February 10, 2018: Bioconjugate Chemistry
Jennifer L J Heaney, Sophie C Killer, Ida S Svendsen, Michael Gleeson, John P Campbell
Periods of short-term intensified training (IT) are often used by athletes during training cycles over the season and undergoing phases of increased physical stress may impact upon the immune system. This study investigated the effects of a period of IT on free light chains (FLCs) in saliva - an emerging immune biomarker of oral inflammation - and matched serum samples in well-trained athletes. It also examined if IT influences basal FLC levels and FLC flux during acute exercise. Highly trained male cyclists (n = 10) underwent a 9-day period of IT; before and after IT participants performed a 1 h time trial (TT) on a cycle ergometer, with blood and saliva samples collected pre- and post-exercise...
February 7, 2018: Physiology & Behavior
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