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https://www.readbyqxmd.com/read/28742550/can-concurrent-abnormalities-in-free-light-chains-and-immunoglobulin-concentrations-identify-a-target-population-for-immunoglobulin-trials-in-sepsis
#1
Manu Shankar-Hari, Mervyn Singer, Jo Spencer
OBJECTIVES: Light chains κ and λ are immunoglobulin constituents but also circulate independently in blood as free light chains. We investigated whether a concomitant abnormality in free light chain and immunoglobulin levels could identify a high risk of death sepsis subpopulation to inform future IV immunoglobulin trials. We tested whether light chain allelic inclusion occurs in circulating B cells. DESIGN: Prospective cohort study. SETTING: Adult general ICUs...
July 22, 2017: Critical Care Medicine
https://www.readbyqxmd.com/read/28738547/effect-of-reflux-ratio-on-nitrogen-removal-in-a-novel-upflow-microaerobic-sludge-reactor-treating-piggery-wastewater-with-high-ammonium-and-low-cod-tn-ratio-efficiency-and-quantitative-molecular-mechanism
#2
Jia Meng, Jiuling Li, Jianzheng Li, Kaiwen Deng, Jun Nan, Pianpian Xu
A novel upflow microaerobic sludge reactor (UMSR) was constructed to treat manure-free piggery wastewater with high NH4(+)-N and low COD/TN ratio. In the light of the potential effect of effluent reflux ratio (RR) on nitrogen removal, performance of the UMSR was evaluated at 35°C and hydraulic retention time 8h with RR decreased from 45 to 25 by stages. A COD, NH4(+)-N and TN removal of above 77.1%, 80.0% and 86.6%, respectively, was kept with a RR over 35. To get an effluent of TN not more than 80mg/L with a TN load removal above 0...
July 11, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/28729748/on-flare-cme-characteristics-from-sun-to-earth-combining-remote-sensing-image-data-with-in-situ-measurements-supported-by-modeling
#3
Manuela Temmer, Julia K Thalmann, Karin Dissauer, Astrid M Veronig, Johannes Tschernitz, Jürgen Hinterreiter, Luciano Rodriguez
We analyze the well-observed flare and coronal mass ejection (CME) from 1 October 2011 (SOL2011-10-01T09:18) covering the complete chain of effects - from Sun to Earth - to better understand the dynamic evolution of the CME and its embedded magnetic field. We study in detail the solar surface and atmosphere associated with the flare and CME using the Solar Dynamics Observatory (SDO) and ground-based instruments. We also track the CME signature off-limb with combined extreme ultraviolet (EUV) and white-light data from the Solar Terrestrial Relations Observatory (STEREO)...
2017: Solar Physics
https://www.readbyqxmd.com/read/28729034/prolonged-renal-survival-in-light-chain-amyloidosis-speed-and-magnitude-of-light-chain-reduction-is-the-crucial-factor
#4
Tamer Rezk, Helen J Lachmann, Marianna Fontana, Sajitha Sachchithanantham, Shameem Mahmood, Aviva Petrie, Carol J Whelan, Jennifer H Pinney, Darren Foard, Thirusha Lane, Taryn Youngstein, Ashutosh D Wechalekar, Paul Bass, Philip N Hawkins, Julian D Gillmore
Renal involvement causing progressive chronic kidney disease (CKD) is present in 70% of patients with systemic Ig light-chain (AL) amyloidosis at diagnosis. Chemotherapy that substantially suppresses free light chain production is associated with improved patient survival, but its benefit in delaying the onset of renal replacement therapy among patients who present with established advanced CKD has not been studied. To evaluate this, we studied 1000 patients enrolled in the prospective UK AL amyloidosis chemotherapy study (ALchemy)...
July 17, 2017: Kidney International
https://www.readbyqxmd.com/read/28728609/multiple-myeloma-can-be-accurately-diagnosed-in-acute-kidney-injury-patients-using-a-rapid-serum-free-light-chain-test
#5
Jennifer L J Heaney, John P Campbell, Punit Yadav, Ann E Griffin, Meena Shemar, Jennifer H Pinney, Mark T Drayson
BACKGROUND: Acute kidney injury (AKI) is common in patients with multiple myeloma (MM). Whether serum free light chain (sFLC) measurements can distinguish between myeloma and other causes of AKI requires confirmation to guide early treatment. A rapid and portable sFLC test (Seralite®) is newly available and could reduce delays in obtaining sFLC results and accelerate diagnosis in patients with unexplained AKI. This study evaluated the accuracy of Seralite® to identify MM as the cause of AKI...
July 20, 2017: BMC Nephrology
https://www.readbyqxmd.com/read/28727070/short-term-heat-stress-causes-altered-intracellular-signaling-in-oxidative-skeletal-muscle
#6
S Ganesan, C M Summers, S C Pearce, N K Gabler, R J Valentine, L H Baumgard, R P Rhoads, J T Selsby
Heat stress (HS) causes morbidities and mortalities, in part by inducing organ-specific injury and dysfunction. Further, HS markedly reduces farm animal productivity, and this is especially true for lean tissue accretion. The purpose of this investigation was to determine the extent to which short-term HS caused muscle dysfunction in skeletal muscle. We have previously found increased free radical injury in skeletal muscle following 24 h of HS. Thus, we hypothesized that HS would lead to apoptosis, autophagy, and decreased mitochondrial content in skeletal muscle...
June 2017: Journal of Animal Science
https://www.readbyqxmd.com/read/28725315/oligoclonal-pattern-abnormal-protein-bands-in-post-treatment-plasma-cell-myeloma-patients-implications-for-protein-electrophoresis-and-serum-free-light-chain-assay-results
#7
Gurmukh Singh
BACKGROUND: The impact of autologous stem cell transplantation (ASCT) in plasma cell myeloma patients on the frequency, quality, and timing of oligoclonal pattern in serum protein electrophoresis/immunofixation electrophoresis (SPEP/SIFE) and serum free light chain assay (SFLCA) was evaluated. METHODS: Laboratory results and clinical data for 251 patients with plasma cell myeloma, who had SPEP/SIFE and/or SFLCA performed between January 2010 and December 2016 were reviewed...
August 2017: Journal of Clinical Medicine Research
https://www.readbyqxmd.com/read/28717256/ketone-catalyzed-photochemical-c-sp-3-h-chlorination
#8
Lei Han, Jibao Xia, Lin You, Chuo Chen
Photoexcited arylketones catalyze the direct chlorination of C(sp(3))-H groups by N-chlorosuccinimide. Acetophenone is the most effective catalyst for functionalization of unactivated C-H groups while benzophenone provides better yields for benzylic C-H functionalization. Activation of both acetophenone and benzophenone can be achieved by irradiation with a household compact fluorescent lamp. This light-dependent reaction provides a better control of the reaction as compared to the traditional chlorination methods that proceed through a free radical chain propagation mechanism...
June 29, 2017: Tetrahedron
https://www.readbyqxmd.com/read/28716013/long-term-renal-survival-of-%C3%AE-3-heavy-chain-deposition-disease-a-case-report
#9
Takayuki Katsuno, Shige Mizuno, Masatsuna Mabuchi, Naotake Tsuboi, Atsushi Komatsuda, Shoichi Maruyama
BACKGROUND: Monoclonal immunoglobulin deposition disease (MIDD) is characterized by the non-amyloid deposition of monoclonal immunoglobulin fragments in the basement membranes. Heavy chain deposition disease (HCDD) is a type of MIDD. HCDD is an extremely rare disease, and only three cases have been reported in Japan up to the present. The prognosis of HCDD is very poor, and optimal treatment has not been established. Only a few cases of HCDD with favorable long-term renal prognosis have been reported to date...
July 17, 2017: BMC Nephrology
https://www.readbyqxmd.com/read/28715966/protective-effects-of-human-chorionic-gonadotropin-against-breast-cancer-how-can-we-use-this-information-to-prevent-treat-the-disease
#10
C V Rao
Breast cancers (BCs) are the most common malignancies among women worldwide. Giving birth to a first child before 24 years of age decreases the BC risk by about half, when women reach menopausal years. The scientific evidence suggests that the actions of human chorionic gonadotropin (hCG) are responsible for this decrease. Human BC cells and tissues contain hCG/luteinizing hormone receptors. The activation of the receptors results in an increase in cell differentiation and apoptosis. Conversely, it decreases the cell proliferation, invasion, and survival...
August 2017: Reproductive Sciences
https://www.readbyqxmd.com/read/28706153/inhibitor-of-growth-protein-4-interacts-with-beclin-1-and-represses-autophagy
#11
Valentina Sica, José Manuel Bravo-San Pedro, Guo Chen, Guillermo Mariño, Sylvie Lachkar, Valentina Izzo, Maria Chiara Maiuri, Mireia Niso-Santano, Guido Kroemer
Beclin 1 (BECN1) is a multifunctional protein that activates the pro-autophagic class III phosphatidylinositol 3-kinase (PIK3C3, best known as VPS34), yet also interacts with multiple negative regulators. Here we report that BECN1 interacts with inhibitor of growth family member 4 (ING4), a tumor suppressor protein that is best known for its capacity to interact with the tumor suppressor protein p53 (TP53) and the acetyltransferase E1A binding protein p300 (EP300). Removal of TP53 or EP300 did not affect the BECN1/ING4 interaction, which however was lost upon culture of cells in autophagy-inducing, nutrient free conditions...
July 6, 2017: Oncotarget
https://www.readbyqxmd.com/read/28701727/free-immunoglobulin-light-chain-flc-promotes-murine-colitis-and-colitis-associated-colon-carcinogenesis-by-activating-the-inflammasome
#12
Junfan Ma, Dongyang Jiang, Xiaoting Gong, Wenwei Shao, Zhu Zhu, Weiyan Xu, Xiaoyan Qiu
Numerous studies have demonstrated that free Ig light chain (FLC), a novel inflammation mediator, participates in many inflammatory diseases by activating mast cells and extending the survival of neutrophils. However, it remains unclear whether FLC is involved in colitis and colitis-associated colon carcinogenesis (CAC). In this study, we found a significant increase in FLC in murine models of DSS (Dextran Sulfate Sodium Salt)-induced colitis and CAC compared to controls. Peptide F991, a functional blocker of FLC, significantly attenuated colitis progression, which included abrogating the development of diarrhea and tumor burden, elevating survival rate, greatly reducing the infiltration of inflammatory cells (such as ROS(+) active neutrophils), especially reducing tumorigenesis in CAC...
July 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28698372/crystal-structure-of-co-bound-cytochrome-c-oxidase-determined-by-serial-femtosecond-x-ray-crystallography-at-room-temperature
#13
Izumi Ishigami, Nadia A Zatsepin, Masahide Hikita, Chelsie E Conrad, Garrett Nelson, Jesse D Coe, Shibom Basu, Thomas D Grant, Matthew H Seaberg, Raymond G Sierra, Mark S Hunter, Petra Fromme, Raimund Fromme, Syun-Ru Yeh, Denis L Rousseau
Cytochrome c oxidase (CcO), the terminal enzyme in the electron transfer chain, translocates protons across the inner mitochondrial membrane by harnessing the free energy generated by the reduction of oxygen to water. Several redox-coupled proton translocation mechanisms have been proposed, but they lack confirmation, in part from the absence of reliable structural information due to radiation damage artifacts caused by the intense synchrotron radiation. Here we report the room temperature, neutral pH (6.8), damage-free structure of bovine CcO (bCcO) in the carbon monoxide (CO)-bound state at a resolution of 2...
July 11, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28693314/plasmonic-vertically-coupled-complementary-antennas-for-dual-mode-infrared-molecule-sensing
#14
Xiahui Chen, Chu Wang, Yu Yao, Chao Wang
Here we report an infrared plasmonic nanosensor for label-free, sensitive, specific, and quantitative identification of nanometer-sized molecules. The device design is based on vertically coupled complementary antennas with densely patterned hot-spots. The elevated metallic nanobars and complimentary nanoslits in the substrate strongly couple at vertical nano-gaps between them, resulting in dual-mode sensing dependent on the light polarization parallel or perpendicular to the nanobars. We demonstrate experimentally that a monolayer of octadecanethiol (ODT) molecules (thickness 2...
July 10, 2017: ACS Nano
https://www.readbyqxmd.com/read/28689003/primary-amyloidosis-with-renal-involvement-outcomes-in-77-consecutive-patients-at-a-single-center
#15
Sandy W Wong, Denis Toskic, Melissa Warner, Cindy Varga, Alejandro Moreno-Koehler, Daniel Fein, Teresa Fogaren, Lisa Lee, Colin M Oliver, Spencer D Guthrie, Raymond L Comenzo
BACKGROUND: Outcomes in primary amyloid renal patients are of interest as the era of monoclonal antibody therapies begins. PATIENTS AND METHODS: We studied 77 consecutive primary amyloid renal patients (58% men) for renal progression (end stage renal disease [ESRD]), renal response (RR), and overall survival (OS). RESULTS: At diagnosis median age was 63 (range, 35-81) years, estimated glomerular filtration rate 70 mL/min (range, 5-114), difference between involved and uninvolved free light chains 127 mg/L (range, 1-9957), ESRD 4%, renal stage 2 and 3 78%, and cardiac stage 2 and 3 56%...
June 17, 2017: Clinical Lymphoma, Myeloma & Leukemia
https://www.readbyqxmd.com/read/28687586/a-rash-with-a-heavy-heart
#16
Sergio Barros-Gomes, Niyada Naksuk, Dragan Jevremovic, Hector R Villarraga
Cardiac amyloidosis (CA) is relatively rare and frequently misdiagnosed. Other disorders presenting with increased left ventricular (LV) mass can mimic its diagnosis. This case illustrates unique findings of primary light chain (AL) amyloidosis in a patient with remarkable signs of CA. Here, we report a 49-year-old man with prior diagnosis of hypertrophy cardiomyopathy (HCM) based on an echocardiogram performed 1 year earlier that presented with 8 weeks of periorbital rash. He had numbness in the past 3 years...
July 7, 2017: Echo Research and Practice
https://www.readbyqxmd.com/read/28686432/synergistic-reinforcing-mechanisms-in-cellulose-nanofibrils-composite-hydrogels-interfacial-dynamics-energy-dissipation-and-damage-resistance
#17
Jun Yang, Feng Xu
Engineering reversible cross-links between nanoparticles and polymer matrix is a promising avenue to reinforce the mechanical properties of elastomers and in particular soft hydrogels. In this work, we study a model system of composite hydrogel reinforced with cellulose nanofibrils (CNFs), where the integration of reversible hydrogen bonds into a lightly covalently cross-linked polyacrylamide (PAAm) matrix. This approach yields the dual cross-linked networks with synergistically improved strength, modulus, and toughness...
July 18, 2017: Biomacromolecules
https://www.readbyqxmd.com/read/28682541/-effect-of-calcitonin-gene-related-peptide-on-mc3t3-e1-osteoblast-apoptosis-and-autophagy-induced-by-serum-starvation
#18
An Yang, Zhang Huiyu, Guo Junfeng, Li Xin, Yang Yang, Zhang Gang, Tan Yinghui
OBJECTIVE: To study the effect of calcitonin gene-related peptide (CGRP) on apoptosis and autophagy of mouse MC3T3-E1 osteoblast and their interaction and to further clarify protective mechanism of CGRP on osteoblasts. METHODS: MC3T3-E1 osteoblasts of mouse were cultured in vitro. Western blot and flow cytometry were used to detect expressions of microtubule-associated protein 1 light chain 3 (LC3) and P62 protein of MC3T3-E1 osteoblasts cultured with serum culture and serum-free (serum starvation) culture...
April 1, 2017: Hua Xi Kou Qiang Yi Xue za Zhi, Huaxi Kouqiang Yixue Zazhi, West China Journal of Stomatology
https://www.readbyqxmd.com/read/28676334/a-patient-with-monoclonal-gammopathy-related-nephrotic-syndrome-revealed-no-electrophoretic-nephrotic-pattern-or-skewed-free-light-chain-ratio
#19
EDITORIAL
Dorothy Truong, Ivan M Blasutig, Vathany Kulasingam, Pak Cheung Chan
No abstract text is available yet for this article.
July 1, 2017: Clinical Biochemistry
https://www.readbyqxmd.com/read/28674366/m-protein-negative-myeloma-mimicking-lumbar-disc-herniation
#20
Yusuke Hirota, Shingo Suzuki, Yota Katsuyama, Tohru Iseki, Masatomi Ikusaka
A 60-year-old man was referred to us with high levels of aspartate aminotransferase and lactate dehydrogenase (LDH). He did not complain of any symptoms; however, he had been diagnosed with lumbar disc herniation, even though his back pain improved only to half of its previous level with pregabalin. Thus, we asked about the red flag of back pain and confirmed that he had involuntary body weight loss, which led us to diagnose truly non-secretory multiple myeloma, a variant of multiple myeloma that is associated with M-protein negativity and a normal serum free light chain level...
2017: Internal Medicine
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