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Wildness medicine

F Pietrantonio, F Di Nicolantonio, A B Schrock, J Lee, F Morano, G Fucà, P Nikolinakos, A Drilon, J F Hechtman, J Christiansen, K Gowen, G M Frampton, P Gasparini, D Rossini, C Gigliotti, S T Kim, M Prisciandaro, J Hodgson, A Zaniboni, V K Chiu, M Milione, R Patel, V Miller, A Bardelli, L Novara, L Wang, S Pupa, G Sozzi, J Ross, M Di Bartolomeo, A Bertotti, S Ali, L Trusolino, A Falcone, F de Braud, C Cremolini
Background: Recognition of rare molecular subgroups is a challenge for precision oncology and may lead to tissue-agnostic approval of targeted agents. Here we aimed to comprehensively characterize the clinical, pathological and molecular landscape of RET rearranged metastatic colorectal cancer (mCRC). Patients and methods: In this case series, we compared clinical, pathological and molecular characteristics of 24 RET rearranged mCRC patients with those of a control group of 291 patients with RET negative tumors...
March 10, 2018: Annals of Oncology: Official Journal of the European Society for Medical Oncology
Mona Dawood, Sami Hamdoun, Thomas Efferth
Arsenic trioxide is a traditional remedy in Chinese Medicine since ages. Nowadays, it is clinically used to treat acute promyelocytic leukemia (APL) by targeting PML/RARA. However, the drug's activity is broader and the mechanisms of action in other tumor types remain unclear. In this study, we investigated molecular modes of action by classical and network pharmacological approaches. CEM/ADR5000 resistance leukemic cells were similar sensitive to As2 O3 as their wild-type counterpart CCRF-CEM (resistance ratio: 1...
2018: Frontiers in Pharmacology
Satisha Hegde, Archana Saini, Harsha Vasudev Hegde, Sanjiva D Kholkute, Subarna Roy
Saraca asoca (Roxb.) De Wilde is an important medicinal plant from the Western Ghats of India, traditionally used in treatment of various gynecological disorders. Increasing commercial demand and decreasing numbers has resulted in this plant becoming endangered with crude drug materials being extensively substituted/adulterated with other plant species. The present study was undertaken with the objective of development and evaluation of multivariate cluster analysis of ISSR fingerprints against rbcL -based DNA barcodes as tool to understand the relationships and to differentiate common adulterants and substituents from S...
March 2018: 3 Biotech
Axel Kulcke, Amadeus Holmer, Philip Wahl, Frank Siemers, Thomas Wild, Georg Daeschlein
Worldwide, chronic wounds are still a major and increasing problem area in medicine with protracted suffering of patients and enormous costs. Beside conventional wound treatment, for instance kinds of oxygen therapy and cold plasma technology have been tested, providing an improvement in the perfusion of wounds and their healing potential, but these methods are unfortunately not sufficiently validated and accepted for clinical practice to date. Using hyperspectral imaging technology in the visible (VIS) and near infrared (NIR) region with high spectral and spatial resolution, perfusion parameters of tissue and wounds can be determined...
March 9, 2018: Biomedizinische Technik. Biomedical Engineering
Anno de Jong, Shabbir Simjee, Farid El Garch, Hilde Moyaert, Markus Rose, Myriam Youala, Magdalena Dry
The European Antimicrobial Susceptibility Surveillance in Animals (EASSA) program collects zoonotic and commensal bacteria from food-producing animals at slaughter and tracks their susceptibility to medically important antibiotics. Results of commensal enterococci species (2013-2014) are presented here. Intestinal content from cattle, pigs and chickens were randomly sampled (5-6 countries/host; ≥4 abattoirs/country; 1 sample/animal/farm) for isolation of enterococci, MICs of 9 antibiotics were assessed by CLSI agar dilution in a central laboratory...
March 2018: Veterinary Microbiology
Li Li, Osama Abdalla Abdelshafy Mohamad, Jinbiao Ma, Ariel D Friel, Yangui Su, Yun Wang, Zulpiya Musa, Yonghong Liu, Brian P Hedlund, Wenjun Li
Little is known about the composition, diversity, and geographical distribution of bacterial communities associated with medicinal plants in arid lands. To address this, a collection of 116 endophytic bacteria were isolated from wild populations of the herb Glycyrrhiza uralensis Fisch (licorice) in Xinyuan, Gongliu, and Tekesi of Xinjiang Province, China, and identified based on their 16S rRNA gene sequences. The endophytes were highly diverse, including 20 genera and 35 species. The number of distinct bacterial genera obtained from root tissues was higher (n = 14) compared to stem (n = 9) and leaf (n = 6) tissue...
March 7, 2018: Antonie Van Leeuwenhoek
Emilia Okragla, Milena Chraniuk, Lidia Wolska
Herbs can be used preventatively, to aid treatment and to ease the symptoms of urinary tract infections (UTIs). Traditional medicine uses herbal infusions such as: lingonberry leaf (Vitis idaeae folium), birch leaf (Betulaefolium) wild thyme extract (Serpylli herba), dwarf everlast flower (Helichrysi inflorescentia), goldenrod (Virgauneae herba, also called Solidaginis herba), restharrow root (Ononidis radix), agrimony (Agrimoniae herba), rowanberry (Sorbi aucupariae fructus), black elderberry (Sambuci fructus), and juniper berry (Juniperifrictus)...
May 2017: Acta Poloniae Pharmaceutica
V Puro, F M Fusco, C Castilletti, F Carletti, F Colavita, C Agrati, A Di Caro, M R Capobianchi, G Ippolito
Orthopoxviruses spill over from animal reservoirs to accidental hosts, sometimes causing human infections. We describe the surveillance and infection control measures undertaken during an outbreak due to an Orthopoxvirus occurred in January 2015 in a colony of Macaca tonkeana in the province of Rieti, Latio, Italy, which caused a human asymptomatic infection. According to the epidemiological investigation, the human transmission occurred after an unprotected exposure. The contacts among wild, captive and domestic animals and humans, together with decreased immunity against Orthopoxviruses in the community, may put animal handlers at risk of infection, especially after the cessation of smallpox vaccination...
March 7, 2018: Zoonoses and Public Health
Shaohua Sun, Jing Cai, Wenjing Tao, Limin Wu, Chakraborty Tapas, Linyan Zhou, Deshou Wang
17α, 20β-dihydroxypregn-4-en-3-one (17α, 20β-DP, DHP), a teleost specific biologically active progestin, has been proved to play a critical role in oocytes maturation, ovulation and spermiation. RU486 (Mifepristone, an antagonist of progestin receptor) has been applied in contraceptives, abortion and hormone therapy in clinical medicine. To get further insights into the molecular mechanisms of nuclear progestin receptor (Pgr) activated ovarian differentiation and maintenance, we conducted comparative gonadal transcriptome analysis, and investigated histological and transcriptional differences using 4 mah (month after hatching) RU486-treated XX and control XX/XY Nile tilapia (Oreochromis niloticus)...
March 3, 2018: General and Comparative Endocrinology
Eirini Sarrou, Lefki-Pavlina Giassafaki, Domenico Masuero, Daniele Perenzoni, Ioannis S Vizirianakis, Maria Irakli, Paschalina Chatzopoulou, Stefan Martens
Hypericum perforatum is known as an important medicinal plant, used for the treatment of several diseases, while its pharmacological properties are attributed to the presence of a wide range of secondary metabolites. Due to the great chemotypic variability of Hypericum species in the nature, and the demand for standardized herbal products, a detailed phytochemical investigation was carried out on different parts (herba, leaf, flowers) from wild collected and cultivated populations, using advanced chromatographic tools...
February 27, 2018: Food and Chemical Toxicology
Anne-Mari Mustonen, Maija Määttänen, Vesa Kärjä, Katri Puukka, Jari Aho, Seppo Saarela, Petteri Nieminen
Rhabdomyolysis (destruction of striated muscle) is a novel form of mushroom poisoning in Europe and Asia indicated by increased circulating creatine kinase levels. Particular wild fungi have also been reported to induce elevated creatine kinase activities in mice. Flammulina velutipes (enokitake or winter mushroom) is one of the most actively cultivated mushroom species globally. As it is marketed as a medicinal mushroom and functional food, it is important to examine whether it could induce potentially harmful health effects similar to some previously studied edible fungi...
January 1, 2018: Experimental Biology and Medicine
Pushpendra Kumar Shukla, Ankita Misra, Manish Kumar, Jaichand, Kuldeep Singh, Juber Akhtar, Sharad Srivastava, Pawan K Agrawal, Ajay K Singh Rawat
Background: Coleus forskohlii is a well-known industrially important medicinal plant, for its high forskolin content. Objective: A simple, selective, and sensitive high-performance thin layer chromatography (HPTLC) method was developed and validated for simultaneous quantification of forskolin and iso-forskolin in C. forskohlii germplasm collected from the Eastern Ghats, India. Materials and Methods: Chromatographic separation of the targeted marker(s) was obtained on precoated silica plates using toluene: ethyl acetate: methanol (90:30:0...
January 2018: Pharmacognosy Magazine
Tomoyuki Sasaki, Toshiaki Shirai, Nagaharu Tsukiji, Shimon Otake, Shogo Tamura, Jiro Ichikawa, Makoto Osada, Kaneo Satoh, Yukio Ozaki, Katsue Suzuki-Inoue
BACKGROUND: Rhodocytin, a disulfide-linked heterodimeric C-type lectin consisting of α- and β-subunits from Calloselasma rhodostoma, induces platelet aggregation through C-type lectin-like receptor 2 (CLEC-2). CLEC-2 is a physiological binding partner of podoplanin (PDPN) expressed on some tumor cell types and is involved in tumor cell-induced platelet aggregation and tumor metastasis. Thus, modified rhodocytin may be a possible source for anti-CLEC-2 medicine in both anti-platelet and anti-metastasis therapy...
February 28, 2018: Journal of Thrombosis and Haemostasis: JTH
Guo-Qiang Yuan, Song Gao, Yong-Jian Geng, Yao-Ping Tang, Min-Juan Zheng, Harnath S Shelat, Scott Collins, Han-Jing Wu, Yi-Ling Wu
Background: Our previous studies have shown that Tongxinluo (TXL), a compound Chinese medicine, can decrease myocardial ischemia-reperfusion injury, protect capillary endothelium function, and lessen cardiac ventricle reconstitution in animal models. The aim of this study was to illuminate whether TXL can improve hypercholesterolemia-impaired heart function by protecting artery endothelial function and increasing microvascular density (MVD) in heart. Furthermore, we will explore the underlying molecular mechanism of TXL cardiovascular protection...
March 5, 2018: Chinese Medical Journal
Hasani Prabodha Sudasinghe, Dinithi C Peiris
Leaves of Passiflora suberosa L. (Family: Passifloraceae; common name: wild passion fruit, devil's pumpkin) are used in Sri Lankan traditional medicine for treating diabetes. The present study investigated the in vivo ability of P. suberosa leaves to manage blood sugar status and associated cholesterol levels. Mechanisms of action and toxicity were also determined. Phytochemical screening of aqueous extracts of P. suberosa leaves and carbohydrate content of the leaves were determined according to previously published methods...
2018: PeerJ
Yan Qun Peng, Ling Ling Fan, Fu Ying Mao, Yun Sheng Zhao, Rui Xu, Yu Jie Yin, Xin Chen, De Guang Wan, Xin Hui Zhang
Polygala tenuifolia Willd. is an important protected species used in traditional Chinese medicine. In the present study, amplified fragment length polymorphism (AFLP) markers were employed to characterize the genetic diversity in wild and cultivated P. tenuifolia populations. Twelve primer combinations of AFLP produced 310 unambiguous and repetitious bands. Among these bands, 261 (84.2%) were polymorphic. The genetic diversity was high at the species level: percentage of polymorphic loci (PPL)=84.2%, Nei's gene diversity (h)=0...
February 21, 2018: Comptes Rendus Biologies
Xiong-Zhe Han, Rui Ma, Qi Chen, Xin Jin, Yuan-Zhe Jin, Ren-Bo An, Xuan-Mei Piao, Mei-Lan Lian, Lin-Hu Quan, Jun Jiang
ETHNOPHARMACOLOGICAL RELEVANCE: The aerial part of Athyrium multidentatum (Doll.) Ching (AM) is widely used in the northeastern region of China as an edible wild herb, but its medicinal value, especially its anti-inflammatory effect, has not been fully explored. AIM OF THE STUDY: To investigate the anti-inflammatory activity of AM and clarify the anti-inflammatory mechanism involving the TLR4 signaling pathway using a lipopolysaccharide (LPS)-induced inflammatory model...
February 21, 2018: Journal of Ethnopharmacology
Karthikeyan Muthusamy, Selvaraman Nagamani
Pharmacogenetics and pharmacogenomics have become presumptive with advancements in next-generation sequencing technology. In complex diseases, distinguishing the feasibility of pathogenic and neutral disease-causing variants is a time consuming and expensive process. Recent drug research and development processes mainly rely on the relationship between the genotype and phenotype through Single nucleotide polymorphisms (SNPs). The SNPs play an indispensable role in elucidating the individual's vulnerability to disease and drug response...
February 12, 2018: Journal of Molecular Graphics & Modelling
Kifayat Ullah Khan, Maqarab Shah, Habib Ahmad, Shujaul Mulk Khan, Inayat Ur Rahman, Zafar Iqbal, Raees Khan, Elsayed Fathi Abd Allah, Abdulaziz Abdullah Alqarawi, Abeer Hashem, Abdullah Aldubise
In the study area, the traditional knowledge regarding the uses of local wild medicinal plants for the health care of human and domestic animals is totally in hold of old people. The young ones are unaware about such an indispensable practices. The objective of the current study was to transfer this sort of precious knowledge from old members of the community to young generations in documented form.
February 2018: Saudi Journal of Biological Sciences
P Comizzoli, E E Paulson, L K McGinnis
Studying the reproductive biology of wild animal species produces knowledge beneficial to their management and conservation. However, wild species also share intriguing similarities in reproductive biology with humans, thereby offering alternative models for better understanding the etiology of infertility and developing innovative treatments. The purpose of this review is to raise awareness in different scientific communities about intriguing connections between wild animals and humans regarding infertility syndromes or improvement of fertility preservation...
February 22, 2018: Journal of Assisted Reproduction and Genetics
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