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https://www.readbyqxmd.com/read/28636672/metabolomic-profile-and-nucleoside-composition-of-cordyceps-nidus-sp-nov-cordycipitaceae-a-new-source-of-active-compounds
#1
Juan Chiriví, Giovanna Danies, Rocio Sierra, Nicolas Schauer, Sandra Trenkamp, Silvia Restrepo, Tatiana Sanjuan
Cordyceps sensu lato is a genus of arthropod-pathogenic fungi, which have been used traditionally as medicinal in Asia. Within the genus, Ophiocordyceps sinensis is the most coveted and expensive species in China. Nevertheless, harvesting wild specimens has become a challenge given that natural populations of the fungus are decreasing and because large-scale culture of it has not yet been achieved. The worldwide demand for products derived from cultivable fungal species with medicinal properties has increased recently...
2017: PloS One
https://www.readbyqxmd.com/read/28632825/-what-do-the-numbers-tell-us-about-the-temporal-evolution-of-chagas-disease
#2
Mauricio Canals, Christian González, Lucia Canals, Andrea Canals, Dante Cáceres, Sergio Alvarado, Pedro E Cattan, Miguel Saavedra, Inés Zulantay, Werner Apt
Chagas disease remains highly prevalent in Chile, especially between the regions of Arica and Parinacota, and Coquimbo. Since 1999 it is considered that in Chile the vector transmission was interrupted. Under this premise, the epidemiological dynamics should be changing. We analyzed the evolution of the prevalence of Chagas' disease analyzing 64,995 xenodiagnosis performed in the laboratory of Parasitology of the Faculty of Medicine of the University of Chile between 1949 and 2014. The evolution of the mortalities and incidences from the databases of the Ministry of Health in the periods in which it was analyzed...
April 2017: Revista Chilena de Infectología: órgano Oficial de la Sociedad Chilena de Infectología
https://www.readbyqxmd.com/read/28629407/antibacterial-activity-of-crude-extracts-of-some-south-african-medicinal-plants-against-multidrug-resistant-etiological-agents-of-diarrhoea
#3
Mary A Bisi-Johnson, Chikwelu L Obi, Babatunde B Samuel, Jacobus N Eloff, Anthony I Okoh
BACKGROUND: This study evaluated the antibacterial activity of some plants used in folklore medicine to treat diarrhoea in the Eastern Cape Province, South Africa. METHODS: The acetone extracts of Acacia mearnsii De Wild., Aloe arborescens Mill., A. striata Haw., Cyathula uncinulata (Schrad.) Schinz, Eucomis autumnalis (Mill.) Chitt., E. comosa (Houtt.) Wehrh., Hermbstaedtia odorata (Burch. ex Moq.) T.Cooke, Hydnora africana Thunb, Hypoxis latifolia Wight, Pelargonium sidoides DC, Psidium guajava L and Schizocarphus nervosus (Burch...
June 19, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28620728/contents-of-heavy-metals-in-chinese-edible-herbs-evidence-from-a-case-study-of-epimedii-folium
#4
Xiao-Hua Yang, Hua-Feng Zhang, Li-Li Niu, Ying Wang, Jiang-Hua Lai
Toxic heavy metal contamination in Chinese edible herbs has raised a worldwide concern. In this study, heavy metals in Epimedii Folium, an edible medicinal plant in China, were quantitatively analyzed. Variations of heavy metals in different species, in various organs (i.e., leaves, stems, and roots), in wild-growing and cultivated plants, and in 35 market samples of Epimedii Folium, were systematically investigated. In all of Epimedium samples, Hg (mercury) was not detectable (0.00 μg/g). Four species, Epimedium pubescens, Epimedium sagittatum, Epimedium brevicornu, and Epimedium wushanense, were found to contain Cu (copper) and Pb (lead)...
June 16, 2017: Biological Trace Element Research
https://www.readbyqxmd.com/read/28616065/human-management-and-hybridization-shape-treegourd-fruits-in-the-brazilian-amazon-basin
#5
Priscila Ambrósio Moreira, Cédric Mariac, Leila Zekraoui, Marie Couderc, Doriane Picanço Rodrigues, Charles R Clement, Yves Vigouroux
Local people's perceptions of cultivated and wild agrobiodiversity, as well as their management of hybridization are still understudied in Amazonia. Here we analyze domesticated treegourd (Crescentia cujete), whose versatile fruits have technological, symbolic, and medicinal uses. A wild relative (C. amazonica) of the cultivated species grows spontaneously in Amazonian flooded forests. We demonstrated, using whole chloroplast sequences and nuclear microsatellites, that the two species are strongly differentiated...
July 2017: Evolutionary Applications
https://www.readbyqxmd.com/read/28608515/efavirenz-clearances-in-vitro-and-in-vivo-in-six-cynomolgus-monkeys-associated-with-polymorphic-cytochrome-p450-2c9-and-simulated-by-individual-physiologically-based-pharmacokinetic-models
#6
Masahiro Utoh, Tomonori Miura, Takashi Kusama, Shotaro Uehara, Makiko Shimizu, Yasuhiro Uno, Hiroshi Yamazaki
Cynomolgus monkey cytochrome P450 2C9 (formerly known as P450 2C43) variation was reportedly associated with metabolic clearance of the antiretroviral drug efavirenz in vivo (of three wild-type, one heterozygote, and two homozygote animals), being unlikely in the case of human P450 2B6-dependent efavirenz clearance. In this study, the liver microsomal elimination rates of efavirenz for the same individual animals previously treated with intravenous/oral administrations of efavirenz showed significant reductions associated with the P450 2C9 p...
June 13, 2017: Biopharmaceutics & Drug Disposition
https://www.readbyqxmd.com/read/28606809/animal-derived-natural-products-used-in-the-bhutanese-sowa-riga-medicine
#7
Karma Yeshi, Paolo Morisco, Phurpa Wangchuk
ETHNOPHARMACOLOGICAL RELEVANCE: Bhutan has two traditional healing systems: a folklore medicine and the Bhutanese Sowa Rigpa medicine (BSM). Three different types of ingredients namely plants, animals (and their derived products) and minerals are used for the preparation of various formulations in combined form. Animals and their derived products are vital ingredients in the preparation of numerous traditional remedies. Unlike medicinal plants, research on medicinal animals has remained largely untouched...
June 9, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28606113/magnetic-resonance-imaging-and-computed-tomography-as-tools-for-the-investigation-of-sperm-whale-physeter-macrocephalus-teeth-and-eye
#8
Aage Kristian Olsen Alstrup, Ole Lajord Munk, Trine Hammer Jensen, Lasse Fast Jensen, Abdi Hedayat, Brian Hansen
BACKGROUND: Scanning techniques such as magnetic resonance imaging (MRI) and computed tomography (CT) are useful tools in veterinary and human medicine. Here we demonstrate the usefulness of these techniques in the study of the anatomy of wild marine mammals as part of a necropsy. MRI and CT scans of sperm whale teeth (n = 4) were performed. The methods were compared and further compared to current standard methods for evaluation of tooth layering. For MRI a zero echo time sequence was used, as previously done for imaging of intact human teeth...
June 12, 2017: Acta Veterinaria Scandinavica
https://www.readbyqxmd.com/read/28603908/depression-profile-in-cancer-patients-and-patients-without-a-chronic-somatic-disease
#9
Christoph Nikendei, Valentin Terhoeven, Johannes C Ehrenthal, Imad Maatouk, Beate Wild, Wolfgang Herzog, Hans-Christoph Friederich
OBJECTIVE: To investigate whether depressed oncology patients show a specific depressive symptom profile, we compared depression symptoms in depressed cancer patients (CANCER-DEP) and depressed patients without a chronic somatic disease (NONCANCER-DEP). METHODS: Of a total of 2493 outpatients from a comprehensive cancer center and a center for psychosocial medicine, 1054 (42.3%) met the DSM-5 criteria for depression, measured with the patient health questionnaire (PHQ-9)...
June 11, 2017: Psycho-oncology
https://www.readbyqxmd.com/read/28603494/yxqn-reduces-alzheimer-s-disease-like-pathology-and-cognitive-decline-in-appsweps1de9-transgenic-mice
#10
Xiaowan Wang, Runmin Song, Wenliang Lu, Ziyu Liu, Lichun Wang, Xiaojuan Zhu, Yanjun Liu, Zijie Sun, Jiang Li, Xiaomeng Li
Alzheimer's disease (AD) is the world's most common form of dementia, in which aggregation of amyloid-β (Aβ) is the hallmark. Unfortunately, few medicines have succeeded to completely cure AD. Yangxue Qingnao (YXQN) is a Chinese traditional medicine, and its pharmacological effect is improving cerebral blood flow. In this study, we firstly demonstrated that YXQN reduced AD-like pathology and cognitive impairment in APPswePS1dE9 (APP/PS1) mice with 2 months administration. Our data showed that YXQN substantially ameliorated behavioral defects in 10-month old APP/PS1 mice using Morris Water Maze and Y-maze tests, in which the cognitive ability of YXQN high-dose group approaches to wild type mice...
2017: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/28598606/4s-hydroxylation-of-insulin-at-prob28-accelerates-hexamer-dissociation-and-delays-fibrillation
#11
Seth A Lieblich, Katharine Y Fang, Jackson K B Cahn, Jeffrey Rawson, Jeanne LeBon, H Teresa Ku, David A Tirrell
Daily injections of insulin provide lifesaving benefits to millions of diabetics. But currently available prandial insulins are suboptimal: The onset of action is delayed by slow dissociation of the insulin hexamer in the subcutaneous space, and insulin forms amyloid fibrils upon storage in solution. Here we show, through the use of noncanonical amino acid mutagenesis, that replacement of the proline residue at position 28 of the insulin B-chain (ProB28) by (4S)-hydroxyproline (Hzp) yields an active form of insulin that dissociates more rapidly, and fibrillates more slowly, than the wild-type protein...
June 20, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28597446/ontogenetic-characterization-of-sporangium-and-spore-of-huperzia-serrata-an-anti-aging-disease-fern
#12
Hua Long, Jing Li, You-You Li, De-Yu Xie, Qing-Zhong Peng, Li Li
BACKGROUND: Huperzia serrata is a medicinal plant used in Traditional Chinese Medicine, which has been used to prevent against aging diseases. It is mainly propagated by spores and grows extremely slowly. Due to severe harvest, it is a highly endangered species. In this report, we characterize ontogenesis of sporangia and spores that are associated with propagation. A wild population of H. serrata plants is localized in western Hunan province, China and protected by Chinese Government to study its development (e...
December 2016: Botanical Studies (Taipei, Taiwan)
https://www.readbyqxmd.com/read/28597443/phenologic-variation-of-major-triterpenoids-in-regular-and-white-antrodia-cinnamomea
#13
Wei-Lun Chen, Yen-Peng Ho, Jyh-Ching Chou
BACKGROUND: Antrodia cinnamomea and its host Cinnamomum kanehirae are both endemic species unique to Taiwan. Many studies have confirmed that A. cinnamomea is rich in polysaccharides and triterpenoids that may carry medicinal effects in anti-cancer, anti-inflammation, anti-hypertension, and anti-oxidation. Therefore it is of interest to study the chemical variation of regular orange-red strains and white strains, which included naturally occurring and blue-light induced white A. cinnamomea...
December 2016: Botanical Studies (Taipei, Taiwan)
https://www.readbyqxmd.com/read/28597416/phytochemical-studies-for-quantitative-estimation-of-iridoid-glycosides-in-picrorhiza-kurroa-royle
#14
Phalisteen Sultan, Arif Jan, Qazi Pervaiz
BACKGROUND: Picrorhiza kurroa Royle commonly known as 'Kutki or Kutaki' is an important medicinal plant in Ayurvedic system of medicine and has traditionally been used to treat disorders of the liver and upper respiratory tract. The plant is the principle source of iridoid glycosides, picrosides I, II and kutkoside used in various herbal drug formulations mainly as strong hepatoprotective and immune-modulatory compound. The species has become endangered to near extinction due to the unregulated collection from the wild, slower plant growth and ecological destruction of natural habitats...
December 2016: Botanical Studies (Taipei, Taiwan)
https://www.readbyqxmd.com/read/28587101/therapeutic-applications-of-rose-hips-from-different-rosa-species
#15
REVIEW
Inés Mármol, Cristina Sánchez-de-Diego, Nerea Jiménez-Moreno, Carmen Ancín-Azpilicueta, María Jesús Rodríguez-Yoldi
Rosa species, rose hips, are widespread wild plants that have been traditionally used as medicinal compounds for the treatment of a wide variety of diseases. The therapeutic potential of these plants is based on its antioxidant effects caused by or associated with its phytochemical composition, which includes ascorbic acid, phenolic compounds and healthy fatty acids among others. Over the last few years, medicinal interest in rose hips has increased as a consequence of recent research that has studied its potential application as a treatment for several diseases including skin disorders, hepatotoxicity, renal disturbances, diarrhoea, inflammatory disorders, arthritis, diabetes, hyperlipidaemia, obesity and cancer...
May 25, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28579438/imiquimod-induced-apoe-deficient-mice-might-be-a-composite-animal-model-for-the-study-of-psoriasis-and-dyslipideamia-comorbidity
#16
Xinran Xie, Lei Zhang, Yan Lin, Yan Wang, Weihong Liu, Xue Li, Ping Li
BACKGROUND: Psoriasis patients are at increased risk of developing lipid metabolism disturbances. Both psoriasis and dyslipideamia not only closely interact in disease development, but occur as mutual side effects in some medicine treatment. The interactive mechanism of the two diseases is complicated and still unclear. OBJECTIVE: Here, we proposed applying imiquimod on the dorsal skin of ApoE(-/-) mice to establish a composite animal model which formed psoriasiform skin lesions under hyperlipidemic condition...
May 17, 2017: Journal of Dermatological Science
https://www.readbyqxmd.com/read/28577572/using-ellenberg-pignatti-values-to-estimate-habitat-preferences-of-wild-food-and-medicinal-plants-an-example-from-northeastern-istria-croatia
#17
Ivana Vitasović Kosić, Josip Juračak, Łukasz Łuczaj
BACKGROUND: The paper presents the first ethnobotanical application of Ellenberg indicator values, which are widely used in European plant ecology. The aim of the study was to find out if Ellenberg values (indicating habitat preferences) differ for wild food and medicinal plants used in north-eastern Istria (Croatia). We used Ellenberg-Pignatti values (the version of Ellenberg values used in this part of Europe). METHODS: Fifty semi-structured interviews were carried out among local key informants, asking which wild food and medicinal plants they used...
June 2, 2017: Journal of Ethnobiology and Ethnomedicine
https://www.readbyqxmd.com/read/28574571/roles-of-macrophage-migration-inhibitory-factor-in-cartilage-tissue-engineering
#18
Yuko Fujihara, Atsuhiko Hikita, Tsuyoshi Takato, Kazuto Hoshi
To obtain stable outcomes in regenerative medicine, understanding and controlling immunological responses in transplanted tissues are of great importance. In our previous study, auricular chondrocytes in tissue-engineered cartilage transplanted in mice were shown to express immunological factors, including macrophage migration inhibitory factor (MIF). Since MIF exerts pleiotropic functions, in this study, we examined the roles of MIF in cartilage regenerative medicine. We made tissue-engineered cartilage consisting of auricular chondrocytes of C57BL/6J mouse, atellocollagen gel and a PLLA scaffold, and transplanted the construct subcutaneously in a syngeneic manner...
June 2, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/28573229/analysis-of-phenolic-and-flavonoids-of-wild-ephedra-alata-plant-extracts-by-lc-pda-and-lc-ms-and-their-antioxidant-activity
#19
Fuad Al-Rimawi, Saleh Abu-Lafi, Jehad Abbadi, Ayman A A Alamarneh, Raneen A Sawahreh, Imad Odeh
BACKGROUND: Ephedra is among Palestinian medicinal plants that are traditionally used in folkloric medicine for treating many diseases. Ephedra is known to have antibacterial and antioxidant effects. The goal of this study is to evaluate the antioxidant activity of different extracts from the Ephedra alata plant growing wild in Palestine, and to analyze their phenolic and flavonoid constituents by HPLC/PDA and HPLC/MS. MATERIALS AND METHODS: Samples of the Ephedra alata plant grown wild in Palestine were extracted with three different solvents namely, 100% water, 80% ethanol, and 100% ethanol...
2017: African Journal of Traditional, Complementary, and Alternative Medicines: AJTCAM
https://www.readbyqxmd.com/read/28566080/-molecular-epidemiology-of-human-mycobacterium-bovis-infection-in-aegean-region-turkey
#20
Cengiz Çavuşoğlu, Fethiye Ferda Yılmaz
Mycobacterium bovis, which has a broader host spectrum as opposed to Mycobacterium tuberculosis that generally causes disease in humans, mainly leads to chronic progressive pulmonary disease in a large number of domestic and wild mammals, particularly cattle. The term "zoonotic tuberculosis (TB)" is used to describe M.bovis infection in humans. "Zoonotic TB" can not be differentiated clinically, radiologically or pathologically from TB caused by M.tuberculosis. The aim of this study was to evaluate the role of M...
April 2017: Mikrobiyoloji Bülteni
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