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https://www.readbyqxmd.com/read/28749256/echocardiographic-findings-of-bidimensional-mode-m-mode-and-doppler-of-clinically-normal-black-rumped-agouti-dasyprocta-prymnolopha-wagler-1831
#1
Anaemilia das Neves Diniz, Gerson Tavares Pessoa, Laecio da Silva Moura, André Braga de Sousa, Francisco das Chagas Araújo Sousa, Renan Paraguassu de Sá Rodrigues, Maria Angélica Parente da Silva Barbosa, Hatawa Melo de Almeida, Larisse Danielle Silva Freire, Marina Pinto Sanches, Antônio Augusto Nascimento Machado Júnior, Porfírio Candanedo Guerra, Willams Costa Neves, João Macedo de Sousa, Luiz Bolfer, Robson Fortes Giglio, Flávio Ribeiro Alves
The black-rumped agouti ( Dasyprocta prymnolopha , Wagler 1831) is currently under intense ecologic pressure, which has resulted in its disappearance from some regions of Brazil. Echocardiography is widely used in veterinary medicine but it is not yet part of the clinical routine for wild animals. The objective of the present study was to assess the applicability of the echocardiographic exam in nonanesthetized agouti and to establish normal reference values for echocardiographic measurements in bidimensional mode (2D), M-mode, and Doppler for this species, and a lead II electrocardiogram was simultaneously recorded...
June 2017: Journal of Zoo and Wildlife Medicine: Official Publication of the American Association of Zoo Veterinarians
https://www.readbyqxmd.com/read/28749058/conservationism-and-bioethic
#2
EDITORIAL
Gregory E Kaebnick
The lead article in this issue of the Hastings Center Report (July-August 2017) explores the ideas underpinning the Precision Medicine Initiative, the effort announced by President Obama in 2015 to promote the development of treatments adjusted to genetic and other variations. Authors Maya Sabatello and Paul Appelbaum hold that the effort works by appealing to a sense of collective identity and shared commitment-an understanding that they call the "PMI nation." But what are the moral implications of this idea? Sabatello and Appelbaum's question about the impact of an imagined community is an unusual way of exploring a set of values questions...
July 2017: Hastings Center Report
https://www.readbyqxmd.com/read/28748169/evaluation-of-fibrinolytic-and-antioxidant-effects-of-allium-elburzense-bulb-extracts
#3
Leila Safaeian, Behzad Zolfaghari, Mohammadreza Aghaye-Ghazvini, Mahya Behnampour
OBJECTIVE: Allium elburzense is an endemic plant of the family Amaryllidaceae that grows wild in northern Iran with some nutritional and medicinal applications. The present study was aimed to investigate the fibrinolytic and antioxidant effects of A. elburzense bulb extracts. MATERIALS AND METHODS: Hydroalcoholic, aqueous, chloroformic and butanolic extracts were evaluated in this research. In vitro antioxidant assays were performed using total phenolic, DPPH, and FRAP methods...
May 2017: Avicenna Journal of Phytomedicine
https://www.readbyqxmd.com/read/28743100/studies-on-secondary-metabolite-profiling-anti-inflammatory-potential-in-vitro-photoprotective-and-skin-aging-related-enzyme-inhibitory-activities-of-malaxis-acuminata-a-threatened-orchid-of-nutraceutical-importance
#4
Biswajit Bose, Hiranjit Choudhury, Pramod Tandon, Suman Kumaria
Malaxis acuminata D. Don., a small, terrestrial orchid, is endemic to tropical Himalayas at an altitude of 1200-2000m asl. The dried pseudobulbs are important ingredients of century old ayurvedic drug 'Ashtavarga' and a polyherbal immune-booster nutraceutical 'Chyavanprash', known to restore vigour, vitality and youthfulness. Considering tremendous medicinal importance of this threatened orchid species, a detailed study was undertaken for the first time to address its antioxidant potential, secondary metabolite contents and biological activities against skin-aging related enzymes (anti-collagenase, anti-elastase, anti-tyrosinase and xanthine oxidase) and anti-inflammatory activity (5-lipoxygenase and hyaluronidase) in different plant parts of wild and in vitro-derived plants of M...
July 12, 2017: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/28739387/effect-of-cortex-mori-on-pharmacokinetic-profiles-of-main-isoflavonoids-from-pueraria-lobata-in-rat-plasma
#5
Bingxin Xiao, Zeng Xian Sun, Shu Yang Sun, Jie Dong, Yanli Li, Shan Gao, Jie Pang, Qi Chang
ETHNOPHARMACOLOGICAL RELEVANCE: Radix pueraria (the root of pueraria lobata (Wild.) Ohwi.), which contains a class of isoflavonoids as the main active components, as well as cortex mori (the root bark of Morus Alba L), which contains abundant active alkaloids, have been employed for the treatment of diabetes in traditional Chinese medicine for centuries. In previous studies, pharmacodynamic synergistic reactions have been observed in compatible application of pueraria lobata isoflavonoids extracts (PLF) and cortex mori alkaloids extracts (CME) for inhibiting α-glycosidase activity...
July 21, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28735292/pathogenesis-of-hypertrophic-cardiomyopathy-is-mutation-rather-than-disease-specific-a-comparison-of-the-cardiac-troponin-t-e163r-and-r92q-mouse-models
#6
Cecilia Ferrantini, Raffaele Coppini, Josè Manuel Pioner, Francesca Gentile, Benedetta Tosi, Luca Mazzoni, Beatrice Scellini, Nicoletta Piroddi, Annunziatina Laurino, Lorenzo Santini, Valentina Spinelli, Leonardo Sacconi, Pieter De Tombe, Rachel Moore, Jil Tardiff, Alessandro Mugelli, Iacopo Olivotto, Elisabetta Cerbai, Chiara Tesi, Corrado Poggesi
BACKGROUND: In cardiomyocytes from patients with hypertrophic cardiomyopathy, mechanical dysfunction and arrhythmogenicity are caused by mutation-driven changes in myofilament function combined with excitation-contraction (E-C) coupling abnormalities related to adverse remodeling. Whether myofilament or E-C coupling alterations are more relevant in disease development is unknown. Here, we aim to investigate whether the relative roles of myofilament dysfunction and E-C coupling remodeling in determining the hypertrophic cardiomyopathy phenotype are mutation specific...
July 22, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28732812/extracts-and-compounds-active-on-trp-ion-channels-from-waldheimia-glabra-a-ritual-medicinal-plant-from-himalaya
#7
Annamaria Giorgi, Angela Bassoli, Gigliola Borgonovo, Sara Panseri, Alessandra Manzo, Daniela Pentimalli, Aniello Schiano Moriello, Luciano De Petrocellis
BACKGROUND: Waldheimia glabra (Decne.) Regel is a wild plant from the Himalayan Mountains, commonly known as Smooth Ground Daisy. This plant is traditionally used by local populations in religious rituals (incense) or in traditional herbal medicine to treat skin diseases, headache, joint pain and fever. In literature few data are available on the investigation of this aromatic plant. PURPOSE: The present work aims at deepening knowledge about the chemical composition of W...
August 15, 2017: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/28732469/microsatellite-marker-development-by-partial-sequencing-of-the-sour-passion-fruit-genome-passiflora-edulis-sims
#8
Susan Araya, Alexandre M Martins, Nilton T V Junqueira, Ana Maria Costa, Fábio G Faleiro, Márcio E Ferreira
BACKGROUND: The Passiflora genus comprises hundreds of wild and cultivated species of passion fruit used for food, industrial, ornamental and medicinal purposes. Efforts to develop genomic tools for genetic analysis of P. edulis, the most important commercial Passiflora species, are still incipient. In spite of many recognized applications of microsatellite markers in genetics and breeding, their availability for passion fruit research remains restricted. Microsatellite markers in P. edulis are usually limited in number, show reduced polymorphism, and are mostly based on compound or imperfect repeats...
July 21, 2017: BMC Genomics
https://www.readbyqxmd.com/read/28730480/identification-and-validation-of-driver-kinases-from-next-generation-sequencing-data
#9
Andri Leonidou, Barrie Peck, Rachael Natrajan
It is well appreciated that activating mutations in kinase genes result in kinome reprogramming that leads to altered downstream signaling networks that drive tumor progression. Indeed small-molecule inhibition of activated kinases has heralded the wave of precision medicine in the past decade. The advent of next-generation sequencing has identified a plethora of potentially activating mutations and fusion genes in previously unreported kinase genes that can potentially be developed as targeted therapies. However, the bottleneck in the translation of these alterations into clinically useful therapies lies in their functional validation...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28720153/molecular-characterization-of-moniezia-sichuanensis-in-captive-musk-deer-moschus-berezovskii
#10
J Xu, H Lin, J Chen, Y Cai, W Fu, H Wang, X Gu, W Lai, X Peng, G Yang
The musk deer (Moschus berezovskii) is an economically important species from which musk is extracted and used in perfumes and medicines. Cestodes (parasitic flatworms) of the genus Moniezia are important parasites that infect this endangered species and can cause high mortality in young deer. In 1982, Moniezia (S.) sichuanensis sp. nov. was described from a specimen obtained from wild musk deer. The new species was distinct from the other described species of Moniezia by the sawtooth-shaped interproglottidal glands, the thick vagina and the absence of a cirrus spine...
July 19, 2017: Journal of Helminthology
https://www.readbyqxmd.com/read/28714761/gamma-irradiation-of-medicinally-important-plants-and-the-enhancement-of-secondary-metabolite-production
#11
P Vivek Vardhan, Lata I Shukla
PURPOSE: The profitable production of some important plant-based secondary metabolites (ginsenosides, saponins, camptothecin, shikonins etc.) in vitro by gamma irradiation is a current area of interest. We reviewed different types of secondary metabolites, their mode of synthesis and effect of γ-radiation on their yield for different plants, organs and in vitro cultures (callus, suspension, hairy root). Special effort has been made to review the biochemical mechanisms underlying the increase in secondary metabolites...
July 17, 2017: International Journal of Radiation Biology
https://www.readbyqxmd.com/read/28713575/wildlife-hosts-for-oie-listed-diseases-considerations-regarding-global-wildlife-trade-and-host-pathogen-relationships
#12
Kristine M Smith, Catherine M Machalaba, Hilary Jones, Paula Cáceres, Marija Popovic, Kevin J Olival, Karim Ben Jebara, William B Karesh
The expanding international wildlife trade, combined with a lack of surveillance for key animal diseases in most countries, represents a potential pathway for transboundary disease movement. While the international wildlife trade represents over US $300 billion per year industry involving exchange of billions of individual animals, animal products, and plants as traditional medicines, meat from wild animals, trophies, live exotic pets, commercial products and food, surveillance and reporting of OIE-Listed diseases in wildlife are often opportunistic...
May 2017: Veterinary Medicine and Science
https://www.readbyqxmd.com/read/28712098/precision-medicine-in-metastatic-colorectal-cancer-relevant-carcinogenic-pathways-and-targets-part-1-biologic-therapies-targeting-the-epidermal-growth-factor-receptor-and-vascular-endothelial-growth-factor
#13
REVIEW
Benjamin A Weinberg, Marion L Hartley, Mohamed E Salem
The survival of patients with metastatic colorectal cancer has improved dramatically in recent years, with overall survival exceeding 3 years in large randomized clinical trials. There are now several treatment options for patients with metastatic colorectal cancer. In addition to chemotherapy backbones utilizing fluoropyrimidine, oxaliplatin, and irinotecan combinations, biologic agents that target specific oncogenic pathways have contributed to the improved survival observed in this patient population. This class of medications includes epidermal growth factor receptor (EGFR)-targeted drugs (cetuximab and panitumumab) and vascular endothelial growth factor (VEGF)-targeted therapies (bevacizumab, ramucirumab, ziv-aflibercept, and regorafenib)...
July 15, 2017: Oncology (Williston Park, NY)
https://www.readbyqxmd.com/read/28706137/assessment-of-pancreatic-neuroendocrine-tumor-cytologic-genotype-diversity-to-guide-personalized-medicine-using-a-custom-gastroenteropancreatic-next-generation-sequencing-panel
#14
Ferga C Gleeson, Jesse S Voss, Benjamin R Kipp, Sarah E Kerr, John S Van Arnam, John R Mills, Cherisse A Marcou, Amber R Schneider, Zheng Jin Tu, Michael R Henry, Michael J Levy
BACKGROUND: Recent genetic studies have highlighted that alterations in MEN1, chromatin remodeling genes, and mammalian target of rapamycin (mTOR) pathway genes are the most frequent molecular events identified in pancreas neuroendocrine tumors (pNETs). The prognostic or predictive impact of these biomarkers and other less frequently observed aberrations, i.e. PTEN, TSC2 and PIK3CA are relatively unknown. The aims of this targeted next generation sequencing (NGS) study were to assess tumor cytology genotype diversity, to survey for potential adverse prognostic biomarkers and the prevalence of mTOR pathway variants...
June 28, 2017: Oncotarget
https://www.readbyqxmd.com/read/28704444/maternal-inheritance-of-deltamethrin-resistance-in-the-salmon-louse-lepeophtheirus-salmonis-kr%C3%A3-yer-is-associated-with-unique-mtdna-haplotypes
#15
Greta Carmona-Antoñanzas, Michaël Bekaert, Joseph L Humble, Sally Boyd, William Roy, David I Bassett, Ross D Houston, Karim Gharbi, James E Bron, Armin Sturm
Parasitic infections by the salmon louse, Lepeophtheirus salmonis (Krøyer), cause huge economic damage in salmon farming in the northern hemisphere, with combined treatment costs and production losses in 2014 having been estimated at US$ 350 million for Norway (annual production 1.25 million tonnes). The control of L. salmonis relies significantly on medicinal treatments, supplemented by non-pharmacological approaches. However, efficacy losses have been reported for several delousing agents, including the pyrethroid deltamethrin...
2017: PloS One
https://www.readbyqxmd.com/read/28702133/cytotoxic-effect-of-rosemary-extract-on-gastric-adenocarcinoma-ags-and-esophageal-squamous-cell-carcinoma-kyse30-cell-lines
#16
Neamat Karimi, Jalil Rashedi, Behroz Mahdavi Poor, Sepideh Arabi, Maryam Ghorbani, Nahideh Tahmasebpour, Mohammad Asgharzadeh
AIM: The present study was conducted to survey the potential cytotoxic influence of freeze-dried aqueous extract of its fruits on gastrointestinal cell lines, namely AGS (human gastric carcinoma) and KYSE30 (human esophageal squamous cell carcinoma. BACKGROUND: Rosemary (Rosmarinus officinalis) is a wild medicinal plant shown to have anticancer activity. Carnosic and rosmarinic acids are compounds, obtained from it through several extraction methods. METHODS: The aqueous extract of the fruits of R...
2017: Gastroenterology and Hepatology From Bed to Bench
https://www.readbyqxmd.com/read/28701020/the-identification-of-araliaceae-species-by-its2-genetic-barcoding-and-pollen-morphology
#17
Arkadiy Reunov, Galina Reunova, Dmitry Atopkin, Yulia Reunova, Tamara Muzarok, Evgeny Zakharov, Yury Zhuravlev
The genetic barcode ITS2 (ITS: internal transcribed spacer) and pollen morphology were used for the identification of the pharmacologically valuable wild Araliaceae species Panax ginseng, Oplopanax elatus, Aralia elata, Aralia continentalis, Eleutherococcus senticosus, and Eleutherococcus sessiliflorus inhabiting the natural forests of Primorye, Russia. The ITS2 locus successfully identified all six species, which supports the use of ITS2 as a standard barcode for medicinal plants. However, the ITS2 locus was insufficient for intra-specific discrimination in these species, neither within Primorye nor from other world representatives within GenBank...
July 12, 2017: Planta Medica
https://www.readbyqxmd.com/read/28687763/a-tyrosine-aminotransferase-involved-in-rosmarinic-acid-biosynthesis-in-prunella-vulgaris-l
#18
Mei Ru, Kunru Wang, Zhenqing Bai, Liang Peng, Shaoxuan He, Yong Wang, Zongsuo Liang
Rosmarinic acid (RA) and its derivants are medicinal compounds that comprise the active components of several therapeutics. We isolated and characterised a tyrosine aminotransferase of Prunella vulgaris (PvTAT). Deduced PvTAT was markedly homologous to other known/putative plant TATs. Cytoplasmic localisation of PvTAT was observed in tobacco protoplasts. Recombinantly expressed and purified PvTAT had substrates preference for L-tyrosine and phenylpyruvate, with apparent K m of 0.40 and 0.48 mM, and favoured the conversion of tyrosine to 4-hydroxyphenylpyruvate...
July 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28686516/standardized-cirsium-setidens-nakai-ethanolic-extract-suppresses-adipogenesis-and-regulates-lipid-metabolisms-in-3t3-l1-adipocytes-and-c57bl-6j-mice-fed-high-fat-diets
#19
Bong-Yeon Cho, Mi-Ryeong Park, Jin-Ha Lee, Moon-Jin Ra, Kyoung Chan Han, Il-Jun Kang, Ok-Hwan Lee
Cirsium setidens Nakai, a wild perennial herb, grows mainly in Gangwon province, Korea, and has been reported to contain bioactive ingredients with various medicinal activities, including the treatment of edema, bleeding, and hemoptysis. However, the potential antiobesity effects of C. setidens Nakai have not been fully investigated. This study evaluated the antiobesity effect of standardized C. setidens Nakai ethanolic extract (CNE) in 3T3-L1 adipocytes and in obese C57BL/6J mice fed a high-fat diet. CNE suppressed the expression of lipogenic genes and increased the expression of lipolytic genes...
July 7, 2017: Journal of Medicinal Food
https://www.readbyqxmd.com/read/28685674/review-on-anti-cancer-activity-in-wild-plants-of-the-middle-east
#20
Einav Mayzlish-Gati, Marcelo Fridlender, Rameshprabu Nallathambi, Gopinath Selvaraj, Stalin Nadarajan, Hinanit Koltai
Plants have been a source of medicine for thousands of years. In many different cultures they became an integral part of local folklore. Plants have since become a source of well-known drugs and pharmaceuticals that are widely used in modern day medicine. Cancer is among the leading causes of mortality worldwide and the number of new cases is expected to rise over the next 2 decades. Some herbal medicines have a therapeutic effect which inhibits cancer via different mechanisms. The Mediterranean basin is one of the richest biodiversity areas in the world...
July 5, 2017: Current Medicinal Chemistry
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