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https://www.readbyqxmd.com/read/28431402/micrometastasis-of-endometriosis-to-distant-organs-in-a-murine-model
#1
Elham N Samani, Ramanaiah Mamillapalli, Fei Li, Levent Mutlu, Demetra Hufnagel, Graciela Krikun, Hugh S Taylor
Endometriosis is an inflammatory gynecological disorder among reproductive-aged women caused by the engraftment and proliferation of endometrial cells outside the uterus, most commonly in the pelvis. It is thought that the disease arises primarily from retrograde menstruation where cells from the endometrium travel through the fallopian tubes to the peritoneal cavity. However, migration of endometriosis-derived cells to distant organs outside of the peritoneal cavity have not been explored. In the present study, we developed and validated a mouse model of disseminated endometriosis using syngeneic DsRed endometrial tissue introduced into the peritoneum of immunocompetent mice...
April 6, 2017: Oncotarget
https://www.readbyqxmd.com/read/28423375/evaluation-of-short-term-efficacy-of-concurrent-chemoradiotherapy-in-primary-fallopian-tube-carcinoma-by-diffusion-weighted-imaging-a-retrospective-study
#2
Ye-Wei Liu, Ya-Fei Du, Hong-Zhen Zhang, Gui-Ying Fang, Yu-Xiang Zhang, Jing Ge, Jing Liu
No abstract text is available yet for this article.
April 20, 2017: Oncology Research and Treatment
https://www.readbyqxmd.com/read/28422362/ultrasound-diagnosis-of-intramural-pregnancy
#3
Na-Na Liu, Xue-Song Han, Xi-Juan Guo, Li-Tao Sun, Xian-Chao Kong
Intramural pregnancy is a rare type of ectopic pregnancy, where the gestational sac is implanted inside the myometrium instead of the endometrial and fallopian tubes. Preoperative diagnosis remains very difficult. Ultrasonic findings vary according to the anatomical location or duration of pregnancy. In this study, we summarized the ultrasonic characteristics of intramural pregnancy by assessing three cases. We also propose a set of ultrasonic characteristics to facilitate differential diagnosis between intramural pregnancy and other types of ectopic pregnancy...
April 19, 2017: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/28414719/crucial-role-of-estrogen-for-the-mammalian-female-in-regulating-semen-coagulation-and-liquefaction-in-vivo
#4
Shuai Li, Marleny Garcia, Rachel L Gewiss, Wipawee Winuthayanon
Semen liquefaction changes semen from a gel-like to watery consistency and is required for sperm to gain mobility and swim to the fertilization site in the Fallopian tubes. Kallikrein-related peptidases 3 (KLK3) and other kallikrein-related peptidases from male prostate glands are responsible for semen liquefaction by cleaving gel-forming proteins (semenogelin and collagen). In a physiological context, the liquefaction process occurs within the female reproductive tract. How seminal proteins interact with the female reproductive environment is still largely unexplored...
April 17, 2017: PLoS Genetics
https://www.readbyqxmd.com/read/28414695/imaging-criteria-to-predict-surgical-difficulties-during-stapes-surgery
#5
Claire Parra, Stéphanie Trunet, Benjamin Granger, Yann Nguyen, Georges Lamas, Daniele Bernardeschi, Rémi Hervochon, Frédéric Tankere
BACKGROUND AND PURPOSE: Stapes surgery for otosclerosis can be challenging if access to the oval window niche is restricted. The aim of this study was to determine the accuracy of the computed tomographic (CT) scan in the evaluation of anatomical distances, and to analyze its reliability in predicting surgical technical difficulties. MATERIAL AND METHODS: A total of 96 patients (101 ears) were enrolled in a prospective study between 2012 and May 2015. During surgery, we evaluated the distance D1 between the stapes and the facial nerve, distance D2 between the promontory and the facial nerve after ablation of the superstructure, and the intraoperative discomfort of the surgeon...
April 13, 2017: Otology & Neurotology
https://www.readbyqxmd.com/read/28412871/the-effect-of-oil-and-water-soluble-contrast-medium-in-hysterosalpingography-on-thyroid-function
#6
Shuhei So, Wakasa Yamaguchi, Hiroko Tajima, Takeshi Nakayama, Naoaki Tamura, Naohiro Kanayama, Fumiko Tawara
Hysterosalpingography (HSG) using iodinated contrast medium is X-ray diagnostic test that examines the inside of the uterus and fallopian tubes in infertile women. In this study, we compared thyroid function (thyroid stimulating hormone: TSH and free-T4: FT4 levels) after HSG with an oil-soluble contrast medium (OSCM) and a water-soluble contrast medium (WSCM). One hundred and sixty-four and 94 patients with normal thyroid function received HSG with OSCM and WSCM, respectively. Approximately 25% of the women in the OSCM group developed subclinical hypothyroidism (SCH), whereas only less than 10% of the patients in the WSCM group developed SCH...
April 17, 2017: Gynecological Endocrinology
https://www.readbyqxmd.com/read/28412735/glucose-deprivation-elicits-phenotypic-plasticity-via-zeb1-mediated-expression-of-nnmt
#7
Justyna Kanska, Paul-Joseph P Aspuria, Barbie Taylor-Harding, Lindsay Spurka, Vincent Funari, Sandra Orsulic, Beth Y Karlan, W Ruprecht Wiedemeyer
Glucose is considered the primary energy source for all cells, and some cancers are addicted to glucose. Here, we investigated the functional consequences of chronic glucose deprivation in serous ovarian cancer cells. We found that cells resistant to glucose starvation (glucose-restricted cells) demonstrated increased metabolic plasticity that was dependent on NNMT (Nicotinamide N-methyltransferase) expression. We further show that ZEB1 induced NNMT, rendered cells resistant to glucose deprivation and recapitulated metabolic adaptations and mesenchymal gene expression observed in glucose-restricted cells...
February 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/28412334/ovotestis-in-adolescence-two-case-reports
#8
Jyoti D Chouhan, David I Chu, Antoinette Birs, Louise C Pyle, Jason P Van Batavia, Rebecca L Linn, Susan J Back, Pierre Russo, Kassa Darge, Thomas F Kolon, Arun K Srinivasan
We present two patients found to have ovotesticular disorder of sexual differentiation (otDSD) in late adolescence. Two 15-year-old phenotypically male patients presented to a large pediatric hospital with different complaints: one with concern for testicular rupture after a straddle injury; the other with gynecomastia. Further work-up, including imaging and lab tests, was performed before surgical exploration. The first patient had unilateral ovotestis, contralateral testis, and SRY-negative 46,XX karyotype...
April 13, 2017: Urology
https://www.readbyqxmd.com/read/28399030/challenging-salpingectomy-as-a-risk-reducing-measure-for-ovarian-cancer-histopathological-analysis-of-the-tubo-ovarian-interface-in-women-undergoing-risk-reducing-salpingo-oophorectomy
#9
Chloe Ayres, Gayanie Ratnayake, Orla McNally, Michael Quinn
OBJECTIVE: Opportunistic bilateral salpingectomy is now promoted for women at the time of hysterectomy for a benign disease, consequent to the fimbrial end of the fallopian tube emerging as the primary site for carcinogenesis in high-grade serous carcinomas. In high-risk women with an identified germ line mutation, bilateral salpingo-oophorectomy offers the greatest risk reduction for ovarian cancer. Currently, no prospective evidence exists with respect to the effectiveness of opportunistic salpingectomy alone in preventing ovarian cancer...
April 8, 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/28394461/successful-treatment-of-infertility-in-a-female-sumatran-orangutan-pongo-abelii
#10
Neil Maclachlan, Gordon Hunt, Sarah Fowkes, Melissa Frost, John Miller, Gari Purcell-Jones, Peter Sullivan, Alberto Barbon, Andrew Routh, Francisco J López, Eluned C Price
In 2011, a female Sumatran orangutan housed at Durrell Wildlife Conservation Trust became infertile following a massive antepartum hemorrhage in labor and the delivery of a stillborn infant. The placenta was infected with Pantoea sp. Hysterosalpingography (HSG) revealed blocked fallopian tubes, and pressurized fallopian tube perfusion was used to reverse the tubal occlusion. She subsequently conceived and following an intensive training program, we were able to measure umbilical artery waveform analysis for fetal well-being and placental localization to exclude placenta previa, which could complicate pregnancy and lead to catastrophic hemorrhage...
March 2017: Zoo Biology
https://www.readbyqxmd.com/read/28392127/ny-eso-1-expression-predicts-an-aggressive-phenotype-of-ovarian-cancer
#11
J Brian Szender, Antonios Papanicolau-Sengos, Kevin H Eng, Anthony J Miliotto, Amit A Lugade, Sacha Gnjatic, Junko Matsuzaki, Carl D Morrison, Kunle Odunsi
OBJECTIVES: NY-ESO-1 is a cancer testis antigen and a promising target for immunotherapy. The purpose of this study was to determine the expression frequency, immunogenicity, and clinical impact of NY-ESO-1 in ovarian cancer. METHODS: Immunohistochemistry (IHC), reverse-transcription polymerase chain reaction (RT-PCR), and quantitative-PCR (qRT-PCR) were utilized in an ovarian cancer (including Fallopian tube and primary peritoneal cancers) patient cohort; humoral responses against NY-ESO-1 were determined by ELISA...
April 6, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/28390945/intraoperative-factors-that-predict-the-successful-placement-of-essure-microinserts
#12
Chloé J Arthuis, Emmanuel G Simon, Thomas Hébert, Henri Marret
OBJECTIVE: To determine whether the number of coils visualized in the uterotubal junction at the end of hysteroscopic microinsert placement predicts successful tubal occlusion. DESIGN: Cohort retrospective study (Canadian Task Force classification II-2). SETTING: Department of obstetrics and gynecology in a teaching hospital. PATIENTS: One hundred and fifty-three women underwent tubal microinsert placement for permanent birth control from 2010 through 2014...
April 5, 2017: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/28390944/congenital-unilateral-fallopian-tube-and-renal-agenesis-in-a-patient-with-primary-infertility
#13
Nigel Pereira, Joshua D Stewart, Alexis P Melnick
The current case highlights the radiologic and hysteroscopic findings of congenital unilateral fallopian tube and renal agenesis in a patient with primary infertility.
April 5, 2017: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/28389043/interventions-to-reduce-the-risk-of-ovarian-and-fallopian-tube-cancer-a-european-menopause-and-andropause-society-postition-statement
#14
REVIEW
Faustino R Pérez-López, Iuliana Ceausu, Herman Depypere, Sean Kehoe, Irene Lambrinoudaki, Alfred Mueck, Levent M Senturk, Tommaso Simoncini, John C Stevenson, Petra Stute, Margaret Rees
BACKGROUND: Ovarian cancer is a leading cause of female gynecological cancer-related death, and there are no effective screening procedures or early diagnostic approaches. AIMS: To examine risk factors and risk-reducing strategies for both sporadic and familial tumors. MATERIALS AND METHODS: Literature review and consensus of expert opinion. RESULTS AND CONCLUSIONS: In women with a genetic predisposition to ovarian cancer, salpingo-oophorectomy reduces the risk of ovarian malignancy, and to a lesser degree of breast cancer...
March 15, 2017: Maturitas
https://www.readbyqxmd.com/read/28386581/paraneoplastic-cerebellar-degeneration-in-a-patient-with-a-primary-fallopian-tube-adenocarcinoma-a-case-report-and-brief-review
#15
Mario Campero, Alberto E Selman
We describe a 65-year-old woman with subacute cerebellar syndrome expressed as severe ataxia, and the presence of anti Purkinje cell antibodies (Anti-Yo). A small adnexal mass was only evident on PET CT with the pathological feature of fallopian tube adenocarcinoma. Anti-Yo antibodies have been strongly associated with paraneoplastic cerebellar degeneration, and nearly always associated to ovarian adenocarcinomas. Few cases have been reported in which this paraneoplastic syndrome has been related to fallopian tube adenocarcinoma...
May 2017: Gynecologic Oncology Reports
https://www.readbyqxmd.com/read/28384944/patient-with-three-fallopian-tubes-at-right-adnexa
#16
Mustafa Gazi Uçar, Tolgay Tuyan Ilhan, Ayhan Gül, Candan Korkutan, Çetin Çelik
No abstract text is available yet for this article.
February 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28376498/comparison-of-early-stage-high-grade-serous-primary-fallopian-tube-cancers-and-epithelial-ovarian-cancers-a-multicenter-study
#17
Kemal Gungorduk, Aykut Ozdemir, Ilker Selcuk, Elcin Telli, Öztürk Şahin, Tayfun Toptaş, Levent Akman, Ahmet B Güzel, Salih Taşkın, Tufan Öge, Özgü Güngördük, Mehmet Gokçü, Tayfun Gungor, Levent Yaşar, Mustafa C Terek, Hakan Ozan, Aydın Ozsaran, Muzaffer Sancı, Mehmet A Vardar, Mehmet M Meydanlı, Ömer T Yalçın, Fırat Ortac, Sinan Özalp
INTRODUCTION: We compared the disease free-survival (DFS) and overall survival (OS) rates of patients with high-grade serous primary fallopian tube cancer (HG-sPFTC) and high-grade serous epithelial ovarian cancer (HG-sEOC). METHODS: 22 early-stage cancer patients (International Federation of Gynecology and Obstetrics (FIGO) stages I-II) with HG-sPFTC were retrospectively evaluated. In addition, 44 control patients diagnosed with HG-sEOC were matched to these patients with respect to tumor stage at diagnosis...
2017: Oncology Research and Treatment
https://www.readbyqxmd.com/read/28357094/high-grade-serous-ovarian-cancer-3-years-after-bilateral-salpingectomy-a-case-report
#18
Emi Sato, Kentaro Nakayama, Masako Ishikawa, Kohei Nakamura, Tomoka Ishibashi, Satoru Kyo
Although epithelial ovarian cancer commonly originates from the ovarian surface epithelium and/or ovarian inclusion cysts, it was recently proposed that high-grade serous ovarian cancer (HGSC) develops from the Fallopian tubes. In our department, we encountered a case of HGSC that contradicts the hypothesis of a tubal origin for HGSC. A 51-year-old postmenopausal woman had undergone hysterectomy, left oophorectomy and bilateral salpingectomy for uterine myoma. Three years later, the patient was diagnosed with stage IV ovarian cancer and underwent primary debulking surgery...
February 2017: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/28356928/a-novel-hysteroscopic-approach-for-ovarian-cancer-screening-early-diagnosis
#19
Salvatore Gizzo, Marco Noventa, Michela Quaranta, Amerigo Vitagliano, Carlo Saccardi, Pietro Litta, Donato Antona
The lethality of epithelial ovarian cancer (EOC) may be due to common misconceptions regarding etiology and the absence of effective screening and early diagnostic tools. Reviews of histopathological surveys performed on the resected fallopian tubes of breast cancer (BRCA) mutation carriers, who underwent risk-reducing salpingo-oophorectomy, unexpectedly revealed the presence of occult carcinomas of the fallopian tubes. This finding prompted studies that demonstrated the most accredited theory of type II EOC development, which suggests that a large proportion of these tumors are derived from the fallopian tube...
February 2017: Oncology Letters
https://www.readbyqxmd.com/read/28353620/electrode-array-displacement-into-the-fallopian-canal-in-revisions-of-long-standing-cochlear-implants
#20
Jennifer Alyono, Garrett Locketz, Carleton Eduardo Corrales, Nikolas H Blevins
OBJECTIVE: To describe extracochlear extension of revision cochlear implant arrays into the Fallopian canal. PATIENTS: Two adult patients with extension of revision cochlear implant arrays into the Fallopian canal. INTERVENTIONS: Computed tomography (CT), selective deactivation of non-functional electrodes. MAIN OUTCOME MEASURES: Facial nerve function, facial nerve stimulation, cochlear implant electrode position, radiography, functional hearing...
March 28, 2017: Otology & Neurotology
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