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https://www.readbyqxmd.com/read/28319578/podoplanin-and-sox2-expression-in-cin-3-like-squamous-cell-carcinoma-of-the-cervix
#1
Colin J R Stewart, Maxine L Crook
Squamous cell carcinoma (SCC) of the uterine cervix occasionally demonstrates a deceptive growth pattern that mimics endocervical crypt involvement by cervical intraepithelial neoplasia, grade 3 (CIN 3). Such CIN 3-like SCCs may be misinterpreted as noninvasive or minimally invasive leading to delays in diagnosis. Little is known of the factors that influence the growth patterns of cervical SCC but we suggested recently that CIN 3-like tumors might demonstrate "collective cellular invasion," which is characterized by a retained epithelial phenotype...
March 17, 2017: International Journal of Gynecological Pathology
https://www.readbyqxmd.com/read/28315935/double-balloon-catheter-for-induction-of-labour-in-women-with-a-previous-cesarean-section-could-it-be-the-best-choice
#2
Carlos De Bonrostro Torralba, Eva Lucía Tejero Cabrejas, Sabina Marti Gamboa, María Lapresta Moros, Jose Manuel Campillos Maza, Sergio Castán Mateo
INTRODUCTION: We analysed the efficacy and safety of double-balloon catheter for cervical ripening in women with a previous cesarean section and which were the most important variables associated with an increased risk of repeated cesarean delivery. MATERIALS AND METHODS: We designed an observational retrospective study of 418 women with unfavourable cervices (Bishop Score <5), a prior cesarean delivery, and induction of labour with a double-balloon catheter...
March 18, 2017: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/28315203/adc-histogram-analysis-of-cervical-cancer-aids-detecting-lymphatic-metastases-a-preliminary-study
#3
Stefan Schob, Hans Jonas Meyer, Nikolaos Pazaitis, Dominik Schramm, Kristina Bremicker, Marc Exner, Anne Kathrin Höhn, Nikita Garnov, Alexey Surov
PURPOSE: Apparent diffusion coefficient (ADC) histogram analysis has been used to some extent in cervical cancer (CC) to distinguish between low-grade and high-grade tumors. Although this differentiation is undoubtedly helpful, it would be even more crucial in the presurgical setting to determine whether a tumor already gained the potential to metastasize via the lymphatic system. So far, no studies investigated the potential of 3T ADC histogram analysis in CC to differentiate between nodal-positive and nodal-negative entities...
March 17, 2017: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://www.readbyqxmd.com/read/28303276/a-parameterized-ultrasound-based-finite-element-analysis-of-the-mechanical-environment-of-pregnancy
#4
Andrea R Westervelt, Michael Fernandez, Michael House, Joy Vink, Chia-Ling Nhan-Chang, Ronald Wapner, Kristin M Myers
Preterm birth is the leading cause of childhood mortality, and can lead to health risks in survivors. The mechanical function of the uterus, fetal membranes, and cervix have dynamic roles to protect the fetus during gestation. To understand their mechanical function and relation to preterm birth, we built a 3-dimensional parameterized finite element model of pregnancy. This model is generated by an automated procedure that is informed by maternal ultrasound measurements. A baseline model at 25 weeks of gestation was characterized, and to visualize the impact of cervical structural parameters on tissue stretch we evaluated the model sensitivity to: (1) anterior uterocervical angle, (2) cervical length, (3) posterior cervical offset, and (4) cervical stiffness...
March 17, 2017: Journal of Biomechanical Engineering
https://www.readbyqxmd.com/read/28302450/the-effect-of-local-treatment-modalities-in-patients-with-early-stage-adenocarcinoma-of-the-uterine-cervix-a-population-based-analysis
#5
Juan Zhou, San-Gang Wu, Jia-Yuan Sun, Feng-Yan Li, Huan-Xin Lin, Da-Hong Chen, Zhen-Yu He
BACKGROUND: To determine the optimal local treatment modalities in stage IB-IIA adenocarcinoma (AC) of the uterine cervix and assess the impact of tumor size in the clinical outcomes. METHODS: Patients with a primary diagnosis of stage IB-II cervix AC between 1988 and 2013 were identified using the Surveillance, Epidemiology, and End Results (SEER) database. Cox regression analyses were performed to analyze the effect of local treatment modalities on cause-specific survival (CSS) and overall survival (OS)...
March 13, 2017: International Journal of Surgery
https://www.readbyqxmd.com/read/28301252/identification-of-optimal-reference-genes-for-normalization-of-rt-qpcr-data-in-cancerous-and-non-cancerous-tissues-of-human-uterine-cervix
#6
Shing Cheng Tan, Mohd Pazudin Ismail, Daniel Roza Duski, Nor Hayati Othman, Venkata Murali Krishna Bhavaraju, Ravindran Ankathil
This study aimed to identify the most stably expressed reference genes from a panel of 32 candidate genes for normalization of reverse transcription-quantitative real-time polymerase chain reaction data in cancerous and non-cancerous tissues of human uterine cervix. Overall, PUM1, YWHAZ, and RPLP0 were identified as the most stably expressed genes in paired cancerous and non-cancerous tissues. The results were further stratified by the state of malignancy of the tissues, histopathological type of the cancer, and the human papillomavirus-type...
March 16, 2017: Cancer Investigation
https://www.readbyqxmd.com/read/28298752/quality-of-labor-epidural-analgesia-and-maternal-outcome-with-levobupivacaine-and-ropivacaine-a-double-blinded-randomized-trial
#7
T Senthil Kumar, P Rani, V R Hemanth Kumar, Sunita Samal, S Parthasarathy, M Ravishankar
BACKGROUND: Quality of labor analgesia plays a vital role in the maternal outcome. Very few literature are available analyzing the quality of epidural labor analgesia. AIM: The aim of this study was to compare the effectiveness of 0.1% levobupivacaine and 0.1% ropivacaine with fentanyl as an adjuvant for epidural labor analgesia in terms of onset, duration, quality of analgesia, and degree of motor blockade. METHODOLOGY: Sixty nulliparous parturients, with singleton uncomplicated pregnancy, were recruited by continuous sampling...
January 2017: Anesthesia, Essays and Researches
https://www.readbyqxmd.com/read/28296773/enhanced-efficacy-of-adjuvant-chemotherapy-and-radiotherapy-in-selected-cases-of-surgically-resected-neuroendocrine-carcinoma-of-the-uterine-cervix-a-retrospective-cohort-study
#8
Sixia Xie, Liang Song, Fan Yang, Chendian Tang, Shaoyan Yang, Ji He, Xiaoling Pan
The aim of the present study is to identify the prognostic factors of overall survival and examine the effects of adjuvant chemotherapy and radiotherapy on the overall survival in neuroendocrine carcinoma of the uterine cervix (NECUC) patients.Forty-eight surgically treated patients were retrospectively recruited and clinicopathologic characteristics and treatments were reviewed. Kaplan-Meier product-limit method and Cox proportional-hazards regression were utilized for univariate and multivariate analyses...
March 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28295721/endometrial-biopsy-in-bos-indicus-beef-heifers
#9
O Ramirez-Garzon, N Satake, R E Lyons, J Hill, M K Holland, M McGowan
An endometrial biopsy allows for a comprehensive assessment of the uterine environment of a breeding female. Although routine in mares, devices used for endometrial biopsies are impracticable in heifers due to the size and structure of the cervix. This report describes the use of a human bronchoscopy biopsy device (Karl Storz(®) 10366L) for collection of endometrial biopsies in Bos indicus beef heifers. The Storz(®) device is smaller and thinner and enabled the collection of an endometrial biopsy in 86% of heifers (n = 44/51)...
March 11, 2017: Reproduction in Domestic Animals, Zuchthygiene
https://www.readbyqxmd.com/read/28288693/uterine-epithelioid-leiomyosarcoma-with-c-kit-expression-and-ywhae-gene-rearrangement-a-case-report-of-a-diagnostic-pitfall-of-uterine-sarcoma
#10
Terufumi Kubo, Shintaro Sugita, Ryuichi Wada, Noriaki Kikuchi, Masahiro Iwasaki, Yumika Ito, Taro Sugawara, Hiromi Fujita, Makoto Emori, Ryoichi Tanaka, Hiroshi Hirano, Tsuyoshi Saito, Tadashi Hasegawa
BACKGROUND: Uterine sarcoma is a rare tumor that is often difficult to classify based on morphological and immunohistochemical analysis alone. Limited access to molecular biological analysis in routine practice would hinder making a definitive diagnosis. CASE PRESENTATION: In this report, we describe a case of a mesenchymal tumor arising from the uterine cervix in a 52-year-old woman. From microscopic morphology of the resected specimen, epithelioid leiomyosarcoma, high-grade endometrial stromal sarcoma, or uterine gastrointestinal stromal tumor (GIST) were considered as differential diagnoses...
March 14, 2017: Diagnostic Pathology
https://www.readbyqxmd.com/read/28280801/a-large-uterine-leiomyoma-leading-to-non-puerperal-uterine-inversion-a-case-report
#11
Batool Teimoori, Arezoo Esmailzadeh
BACKGROUND: Although leiomyomas are the most common gynecologic disorders, non-puerperal uterine inversion due to leiomyoma is considered as a rare clinical problem. This condition can occur as a complication of a large sub-mucous leiomyoma that leads to dilate cervix and protrude into vagina. The patient may have several symptoms such as heavy vaginal bleeding, pelvic pain and intermittent acute urinary retention. CASE: We presented a 32-year-old nulliparous woman with 17 years of unexplained infertility and diagnosis of a large vaginal prolapsed non-pedunculated leiomyoma...
January 2017: International Journal of Reproductive Biomedicine (Yazd, Iran)
https://www.readbyqxmd.com/read/28277359/vaginal-delivery-after-d%C3%A3-hrssen-incisions-in-a-patient-with-bladder-exstrophy-and-uterine-prolapse
#12
Ruben Lachica, Yen Chan, Kristen R Uquillas, Richard H Lee
BACKGROUND: Bladder exstrophy is a rare congenital anomaly affecting the lower abdominal wall, pelvis, and genitourinary structures. Pregnant women with bladder exstrophy present a unique challenge to the obstetrician. CASE: The patient is a 35-year old pregnant woman with bladder exstrophy, an extensive surgical history, and uterine prolapse with an abnormal, rubbery consistency to her cervix. Prenatally, she was counseled on the potential use of Dührssen incisions to facilitate vaginal delivery...
March 6, 2017: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28277315/clear-cell-carcinoma-of-the-uterine-cervix-presented-as-submucosal-tumor-arising-from-a-background-of-cervical-endometriosis
#13
Mariko Hashiguchi, Keita Kai, Satoshi Nishiyama, Yoshifumi Nakao, Masatoshi Yokoyama, Shinichi Aishima
Clear cell carcinoma (CCC) of the uterine cervix without prenatal diethylstilbestrol exposure is rare, and its etiology is unclear. We present a case of cervical CCC presenting as a submucosal tumor, which strongly suggests an association between cervical endometriosis and cervical CCC. A 56-year-old postmenopausal Japanese woman visited a gynecologic clinic with a complaint of watery vaginal discharge. A few atypical cells suggesting adenocarcinoma were detected in a cervical cytologic specimen. Magnetic resonance imaging revealed a cystic lesion with a solid component at the uterine cervix...
March 8, 2017: International Journal of Gynecological Pathology
https://www.readbyqxmd.com/read/28254504/robotic-assisted-laparoscopic-trachelectomy-a-standard-technique
#14
Mohamad S Mahmoud
STUDY OBJECTIVE: To describe a standard reproducible technique for simple robotic assisted laparoscopic trachelectomy DESIGN: Step-by-step explanation of the technique using videos and pictures (educative video). SETTING: The incidence of trachelectomy after supracervical hysterectomy has been increasing given the popularity of supracervical hysterectomy . The most common indication for trachelectomy is symptomatic cyclic bleeding. Trachelectomy can be preformed vaginally as well as laparoscopically with or without robotic assistance...
February 27, 2017: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/28244895/peripheral-t-cell-lymphoma-presenting-as-a-primary-uterine-cervix-mass-a-report-of-a-rare-case
#15
Farid Kosari, Nakisa Niknejad, Fatemeh Nili, Behnaz Jahanbin, Mahrooz Malek
Malignant lymphoma is a rare form of malignancy in the uterine cervix. Most of the previously reported cases were B-cell lymphomas. We present a case of primary peripheral T-cell lymphoma, not otherwise specified, in the uterine cervix in a 49-year-old woman with a history of severe vaginal bleeding. The patient was treated with a CHOP (cyclophosphamide, adriamycin, vincristine, and prednisolone) chemotherapy regimen and 28 cycles of radiotherapy. Three months later, she presented with generalized lymphadenopathy and sudden left-eye ptosis as a complication of CNS involvement and died after 20 months from the initial disease presentation...
February 27, 2017: International Journal of Gynecological Pathology
https://www.readbyqxmd.com/read/28242988/-18-f-fluorodeoxyglucose-positron-emission-tomography-computed-tomography-scan-in-an-unusual-case-of-lymphoma-with-secondary-involvement-of-uterine-cervix-presenting-as-a-pathological-fracture
#16
Arun Sasikumar, Ajith Joy, M R A Pillai, Boben Thomas
A 48-year-old female presented with a pathological fracture of the right femur. (99m)Tc methylene diphosphonate bone scan revealed multiple areas of increased osteoblastic activity consistent with metastatic disease. Serum electrophoresis revealed monoclonal gammopathy. (18)F-fluorodeoxyglucose positron emission tomography/computed tomography ((18)F-FDG PET/CT) scan revealed metabolically active lesions in bulky uterine cervix and osteolytic skeletal lesions. Unusual pattern of FDG uptake in uterine cervix and osteolytic skeletal lesions warranted a biopsy of the uterine cervix which revealed diffuse large B-cell lymphoma...
January 2017: Indian Journal of Nuclear Medicine: IJNM: the Official Journal of the Society of Nuclear Medicine, India
https://www.readbyqxmd.com/read/28230268/potential-climate-change-health-risks-from-increases-in-heat-waves-abnormal-birth-outcomes-and-adverse-maternal-health-conditions
#17
Gulcan Cil, Trudy Ann Cameron
We investigate the risks presented by heat waves for adverse health conditions for babies and expectant mothers when these mothers have been exposed to heat waves during gestation or during the period just prior to conception. Rather than just birth weight and gestational age, we focus on less common metrics such as abnormal conditions in the newborn (fetal distress, reliance on a ventilator, and meconium aspiration) and adverse health conditions in the mother (pregnancy-related hypertension, uterine bleeding during pregnancy, eclampsia, and incompetent cervix)...
February 23, 2017: Risk Analysis: An Official Publication of the Society for Risk Analysis
https://www.readbyqxmd.com/read/28223433/global-cancer-in-women-burden-and-trends
#18
Lindsey A Torre, Farhad Islami, Rebecca L Siegel, Elizabeth M Ward, Ahmedin Jemal
There are striking disparities in the global cancer burden in women, yet few publications highlight cancer occurrence in this population, particularly for cancers that are not sex-specific. This paper, the first in a series of two, summarizes the current burden, trends, risk factors, prevention, early detection, and survivorship of all cancers combined and seven sites (breast, cervix, uterine corpus, ovary, colorectum, lung, and liver) that account for about 60% of the cancer burden among women worldwide, using data from the International Agency for Research on Cancer...
February 21, 2017: Cancer Epidemiology, Biomarkers & Prevention
https://www.readbyqxmd.com/read/28217685/right-ventricular-metastatic-tumor-from-a-primary-carcinoma-of-uterine-cervix-a-cause-of-pulmonary-embolism
#19
Gwan Hee Han, Do Youn Kwon, Roshani Ulak, Kyung Do Ki, Jong-Min Lee, Seon-Kyung Lee
The presence of intracavitary cardiac metastasis from squamous cell carcinoma of the uterine cervix is extremely rare. The diagnosis is made almost exclusively postmortem. Apart from causing intracardiac obstruction, it can present as pulmonary emboli and the prognosis is extremely poor. It is important to suspect this diagnosis in patient with recurrent pulmonary emboli. Due to the rarity of this condition it is very difficult to standardize care for these patients. However, it is possible that aggressive therapy may lengthen patients' survival and quality of life...
January 2017: Obstetrics & Gynecology Science
https://www.readbyqxmd.com/read/28217683/lymphoepithelioma-like-carcinoma-of-the-uterine-cervix
#20
Hyun Sil Yun, Sun Kyung Lee, Gun Yoon, Hwi Gon Kim, Dong Hyung Lee, Yong Jin Na, Ook Hwan Choi, Dong Hoon Shin, Yong Jung Song
Lymphoepithelioma-like carcinoma (LELC) of the uterine cervix is exceedingly uncommon. We herein report a rare case of cervical LELC. A 45-year-old woman was admitted to gynecology department with vaginal bleeding for one month. Liquid-based cytology revealed atypical endometrial cells, not otherwise specified on her cervix. On a hysteroscopy, an endocervical mass was identified and the pathologic result was consistent with poorly differentiated squamous cell carcinoma. Magnetic resonance imaging and positron emission tomography with 2-deoxy-2-[fluorine-18] fluoro-D-glucose integrated with computed tomography revealed a 3...
January 2017: Obstetrics & Gynecology Science
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