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https://www.readbyqxmd.com/read/29223946/-quality-of-the-exo-endocervical-sampling-in-the-prevention-of-uterine-cervix-cancer
#1
Anabela A Angeleri, Lili B Díaz, Gisela Coliva, Fernando Guerra, Luis A Palaoro, Adriana E Rocher
Cervical and vaginal cytology, Papanicolaou test (PAP), is the most effective test for screening of preneoplastic lesions, and cervical cancer prevention. Its sensitivity goes from 50 to 98%, according to different statistics, and this variation is related to the sampling procedure. A satisfactory smear should be taken from the transformation zone, the junction between endocervix and exocervix. According to Bethesda, metaplastic and/or endocervical cells should be observed under the microscope. The traditional PAP smear includes an exo-endocervical sampling using the Ayre spatula; however, only near 50% of the smears are representative of the transformation zone...
2017: Medicina
https://www.readbyqxmd.com/read/29223564/indocyanine-green-assisted-parametrial-dissection-during-type-c1-radical-hysterectomy-after-sentinel-lymph-node-biopsy-in-early-stage-cervical-cancer
#2
Nicolò Bizzarri, Valentina Ghirardi, Ali Kucukmetin
OBJECTIVES: The standard treatment for FIGO stage 1B1 cervical cancer is radical hysterectomy (RH) [1]. Indocyanine-green (ICG) is a drug injected within the cervical stroma to detect the sentinel lymph node (SLN) in cervical cancer [2,3]. ICG travels through the lymphatic channels in the lateral parametrium, which results enhanced with green, before reaching the SLNs. This could help identifying the surgical landmarks. The aim of this video is to propose a new approach to perform parametrial dissection as part of RH under the guidance of ICG...
December 6, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/29218797/lymphoepithelioma-like-carcinoma-of-the-uterine-cervix-cytomorphologic-features-and-diagnostic-pitfalls-by-liquid-based-cytology
#3
Isaac Lloyd, Barbara Chadwick
Lymphoepithelioma-like carcinoma (LELC) is a rare variant of cervical squamous cell carcinoma with unclear HPV and EBV association. Due to the accompanying and often obscuring lymphocytic inflammation, malignant cells may be difficult to recognize on cytologic samples and can mimic several more common benign and atypical cervical lesions. In this case report, we describe the cytomorphologic findings of LELC by liquid-based cytology in a 59-year-old Caucasian woman who was positive for high risk HPV but had no visible cervical lesions...
December 8, 2017: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/29211326/recent-work-supports-the-concept-of-an-active-sphincter-in-the-uterine-cervix
#4
Helen Feltovich, Joy-Sarah Vink
In this issue, Nott et al. qualitatively and quantitatively investigate the architecture of the cervix in ex vivo nonpregnant human samples. Using Diffusion Tensor MRI and a fiber tracking algorithm, they identify an outer circular and inner longitudinal layer of fibers throughout the cervix. Quantitative measurements of diffusion, tract orientation and volume confirm that the outer circumferential band of fibers is particularly dense and uniform in the proximal cervix, at the region of the internal os. This article is protected by copyright...
December 6, 2017: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/29207716/expression-of-p16ink4a-protein-in-cervical-intraepithelial-neoplasia-and-invasive-carcinoma-of-uterine-cervix
#5
Vatsala Kishore, Anuradha G Patil
Introduction: Cervical cancer still ranks as the most frequent cancer among women in India. Infection with Human Papilloma Virus (HPV) results in precancerous lesions and invasive cervical cancer. Interaction of HPV oncogenic proteins with cellular regulatory proteins leads to upregulation of p16INK4A, a cyclin dependent kinase inhibitor. Therefore, p16INK4A overexpression is a surrogate biomarker of HPV infection making it useful in evaluating HPV associated premalignant and malignant lesions of gynaecological tract...
September 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/29207712/role-of-her-2-neu-in-premalignant-and-malignant-lesions-of-uterine-cervix
#6
Swasti Bajpai, Seema Awasthi, Shyamoli Dutta, Ankita Mittal, Ashutosh Kumar, Faiyaz Ahmad
Introduction: In light of literature and controversy that exists in various cervical lesions, this prospective study was designed to explore the expression of Human Epidermal Growth Factor Receptor-2 (HER-2/neu) in the cervical lesions and its correlation with the histopathological grade and type of tumour. Immunohistochemistry (IHC) was performed to evaluate HER-2/neu expression as it is the most reliable method of detecting overexpression of HER-2/neu. Aim: To assess the role of HER-2/neu expression in premalignant and malignant lesions of uterine cervix...
September 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/29206664/chemoresistance-of-gastric-type-mucinous-carcinoma-of-the-uterine-cervix-a-study-of-the-sankai-gynecology-study-group
#7
Atsumi Kojima, Muneaki Shimada, Yoshiki Mikami, Shoji Nagao, Nobuhiro Takeshima, Toru Sugiyama, Norihiro Teramoto, Takako Kiyokawa, Junzo Kigawa, Ryuichiro Nishimura
OBJECTIVE: Gastric-type mucinous carcinoma (GAS) is a novel variant of mucinous carcinoma of the uterine cervix, characterized by aggressive clinical behavior and absence of high-risk human papillomavirus. We conducted this study to evaluate the chemosensitivity of GAS compared with that of usual-type endocervical adenocarcinoma (UEA) in patients who had been enrolled in our previous study. METHODS: Of 52 patients from our previous phase 2 study (SGSG005) of neoadjuvant chemotherapy with docetaxel and carboplatin for stage IB2 to IIB nonsquamous cervical cancer, 47 (stage IB2, 12; stage IIA2, 7; stage IIB, 28) were enrolled in this study with written informed consent...
December 4, 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/29206662/surgery-versus-radiation-treatment-for-high-grade-neuroendocrine-cancer-of-uterine-cervix-a-surveillance-epidemiology-and-end-results-database-analysis
#8
Wei-Hsien Hou, Tim E Schultheiss, Jeffrey Y Wong, Mark T Wakabayashi, Yi-Jen Chen
OBJECTIVES: The objective of this study was to assess treatment and other factors impacting survival in cervical high-grade neuroendocrine carcinoma (HGNEC). METHODS/MATERIALS: We identified patients with cervical HGNECs diagnosed during 1988 to 2012 in the Surveillance Epidemiology and End Results database. We determined overall survival by International Federation of Gynecology and Obstetrics stages and by local treatment modalities, that is, radical surgery versus external beam radiation treatment (EBRT) plus brachytherapy using Kaplan-Meier analysis with log-rank test...
December 4, 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/29202724/epcam-expression-in-squamous-cell-carcinoma-of-the-uterine-cervix-detected-by-monoclonal-antibody-to-the-membrane-proximal-part-of-epcam
#9
Warangkana Chantima, Charin Thepthai, Pornsuk Cheunsuchon, Tararaj Dharakul
BACKGROUND: Epithelial cell adhesion molecule (EpCAM) is a promising biomarker for squamous cell carcinoma (SCC) of the uterine cervix, because it is over-expressed in various cancers of epithelial origin. However, EpCAM expression reported in previous immunohistochemistry (IHC) studies was inconsistent. We hypothesize that the membrane-distal part of EpCAM may be lost during tissue preparation, leaving only the membrane-proximal part of EpCAM available for antibody binding and IHC staining...
December 4, 2017: BMC Cancer
https://www.readbyqxmd.com/read/29199806/selective-progesterone-receptor-modulators-new-possibilities-for-gynecologic-hormone-therapy
#10
Nanna Sarvilinna, Leila Unkila-Kallio, Päivi Härkki, Aila Tiitinen, Oskari Heikinheimo
Progesterone regulates several female reproductive functions. Progesterone and synthetic progestins derived from it have long been utilized in gynecology. The effects of these steroids in target cells are mediated via progesterone receptors, Progesterone receptors are also the target of action of selective progesterone receptor modulators. Of the molecules of this newer group of drugs, two are presently in clinical use. Mifepristone is used in nonsurgical abortion, in softening of the cervix before surgical abortion, and in the induction of labor in cases of intrauterine death...
2017: Duodecim; Lääketieteellinen Aikakauskirja
https://www.readbyqxmd.com/read/29199729/epidemiology-of-gynecological-cancers-in-kamrup-urban-district-cancer-registry
#11
D Barman, J D Sharma, D Barmon, A C Kataki, A Sharma, M Kalita
BACKGROUND: Cancers of the female reproductive system - namely cancer of the cervix, corpus uteri, ovarian, vulvar, vaginal, fallopian tube cancers and choriocarcinoma are an important cause of cancer morbidity and mortality among women worldwide. It is estimated to be the third most common group of malignancies in women. The comprehensive global cancer statistics from the International Agency for Research on Cancer indicate that gynaecological cancers accounted for 20% of the 14.1 million estimated new cancer cases and 8...
January 2017: Indian Journal of Cancer
https://www.readbyqxmd.com/read/29198328/the-role-of-nuclear-factor-kappa-b-signaling-in-human-cervical-cancer
#12
REVIEW
Sam Tilborghs, Jerome Corthouts, Yannick Verhoeven, David Arias, Christian Rolfo, Xuan Bich Trinh, Peter A van Dam
Background The Nuclear Factor kappaB (NF-kB) family consists of transcription factors that play a complex and essential role in the regulation of immune responses and inflammation. NF-kB has recently generated considerable interest as it has been implicated in human cancer initiation, progression and resistance to treatment. In the present comprehensive review the different aspects of NF-kB signaling in the carcinogenesis of cancer of the uterine cervix are discussed. NF-kB functions as part of a network, which determines the pattern of its effects on the expression of several other genes (such as crosstalks with reactive oxygen species, p53, STAT3 and miRNAS) and thus its function...
December 2017: Critical Reviews in Oncology/hematology
https://www.readbyqxmd.com/read/29193907/tuberculosis-in-pap-samples-with-emphasis-on-lbc-caught-only-when-thought
#13
Vani Bharani, Nalini Gupta, Vanita Suri, Arvind Rajwanshi
Despite being a commonly encountered infection, the clinical diagnosis of tuberculosis of the uterine cervix is elusive. Though a straightforward diagnosis on tissue sections, identification of typical features of tubercular infection on cervical Pap samples is challenging. In our experience, the infrequent pale staining collections of epithelioid cells are difficult to pick up on Pap stained smears, particularly LBC samples. In this series, 2 of the three samples were reported as atypical squamous cells of undetermined significance while 1 was reported as inflammatory at the initial diagnosis...
November 28, 2017: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/29192747/-situational-diagnosis-of-cancer-care-at-the-instituto-mexicano-del-seguro-social
#14
Sonia Patricia de Santillana-Hernández, María Teresa García-Flores, Héctor Galván-Oseguera, Gilberto Pérez-Rodríguez, Héctor David Martínez-Chapaca
Cancer is a public health problem with an impact on Health Services in Mexico; it is also, one of the leading causes of mortality (mortality rate: 610.6 / 100 000) and is expected to double the total number of new cases by 2035 (GLOBOCAN). The most frequent neoplasms are the malignant tumor of breast, prostate, cervix and uterin, colorectal and pulmonary. The most affected groups are the female, and by age the 65 years and older (INEGI). At the IMSS, the mortality rate for malignant tumors has varied, with a sustained decline since 2010...
2017: Revista Médica del Instituto Mexicano del Seguro Social
https://www.readbyqxmd.com/read/29189288/clinicopathologic-and-molecular-characteristics-of-mesonephric-adenocarcinoma-arising-from-the-uterine-body
#15
Kiyong Na, Hyun-Soo Kim
Mesonephric adenocarcinoma (MNAC) is a rare tumor of the female genital tract mainly occurring in the uterine cervix. To date, only a few cases of MNAC arising from of the uterine body (UB-MNAC) have been reported. The clinicopathologic and molecular characteristics of UB-MNAC remain unknown. In this study, we investigated the clinical, histopathologic, immunohistochemical, and genetic features of UB-MNAC. In total, 11 cases were included. Six patients developed metastatic disease, most commonly in lungs (5/6)...
November 17, 2017: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29186874/do-cervical-cancer-patients-diagnosed-with-opportunistic-screening-live-longer-an-arkhangelsk-cancer-registry-study
#16
Elena E Roik, Evert Nieboer, Olga A Kharkova, Andrej M Grjibovski, Vitaly A Postoev, Jon Ø Odland
The aim of the current study was to compare cervical cancer (СС) patients diagnosed with and without screening in terms of: (i) sociodemographic and clinical characteristics; (ii) factors associated with survival; and (iii), and levels of risk. A registry-based study was conducted using data from the Arkhangelsk Cancer Registry. It included women with newly diagnosed malignant neoplasm of the uterine cervix during the period of 1 January 2005 to 11 November 2016 (N = 1548). The Kaplan-Meier method, the log-rank test, and Cox regression were applied...
November 26, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29179875/surgical-staging-identified-false-hpv-negative-cases-in-a-large-series-of-invasive-cervical-cancers
#17
Karl Ulrich Petry, Clemens Liebrich, Alexander Luyten, Martina Zander, Thomas Iftner
OBJECTIVE: We examined a large series of biopsy-proven invasive cervical cancers with surgical staging and HPV re-testing to estimate the relevance of HPV-negative cervical cancers in a Caucasian population. METHODS: We prospectively collected smears from 371 patients with a biopsy-proven diagnosis of cervical cancer for HC2 testing of high-risk HPV (HR-HPV). In HC2-negative cases, smears and paraffin embedded tissue blocks underwent additional HPV genotyping. RESULTS: HC2 tests showed 31/371 cases (8...
December 2017: Papillomavirus Research
https://www.readbyqxmd.com/read/29179240/assessment-of-length-of-maternal-cervix-between-18-and-24-weeks-of-gestation-in-a-low-risk-brazilian-population
#18
Soraya Gomes de Amorim Andrade, Fernando Moreira de Andrade, Edward Araujo Júnior, Cláudio Rodrigues Pires, Rosiane Mattar, Antonio Fernandes Moron
Purpose To determine cervical biometry in pregnant women between 18 and 24 weeks of gestation and the ideal mode of measurement of cervical length in cases of curved and straight cervical morphology. Methods The uterine cervices of 752 low-risk pregnant women were assessed using transvaginal ultrasound in a prospective cross-sectional study. In women with straight uterine cervices, cervical biometry was performed in a continuous manner. In women with curved uterine cervices, the biometry was performed using both the continuous and segmented techniques (in segments joining the cervical os)...
November 27, 2017: Revista Brasileira de Ginecologia e Obstetrícia
https://www.readbyqxmd.com/read/29178414/developing-and-validating-a-multivariable-prediction-model-to-improve-the-diagnostic-accuracy-in-determination-of-cervical-versus-endometrial-origin-of-uterine-adenocarcinomas-a-prospective-mr-study-combining-diffusion-weighted-imaging-and-spectroscopy
#19
Gigin Lin, Yu-Chun Lin, Ren-Chin Wu, Lan-Yan Yang, Hsin-Ying Lu, Shang-Yueh Tsai, Yu-Ting Huang, Yen-Ling Huang, Kuan-Ying Lu, Koon-Kwan Ng, Tzu-Chen Yen, Angel Chao, Chyong-Huey Lai, Ji-Hong Hong
BACKGROUND: A triage test to assist clinical decision-making on choosing primary chemoradiation for cervical carcinomas or primary surgery for endometrial carcinomas is important. PURPOSE OR HYPOTHESIS: To develop and validate a multiparametric prediction model based on MR imaging and spectroscopy in distinguishing adenocarcinomas of uterine cervical or endometrial origin. STUDY TYPE: Prospective diagnostic accuracy study. POPULATION: Eighty-seven women: 25 cervical and 62 endometrial adenocarcinomas divided into training (n = 43; cervical/endometrial adenocarcinomas = 11/32) and validation (n = 44; 14/30) datasets...
November 27, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/29172262/modulatory-effects-of-chemoradiation-on-angiogenic-factors-and-laminin-in-cervical-cancer-link-with-treatment-response
#20
Manoj Sharma, Rehan Khan, Mayank Aggarwal, Alpana Sharma
Objective: Carcinoma of the uterine cervix is either the first or second most common malignancy in Indian women, depending on the registry. Tumor growth and metastasis primarily are determined by angiogenesis and parameters of the molecular environment including extracellular matrix elements, growth factors and cytokines. Effects of chemo-irradiation on biomarkers like vascular endothelial growth factor (VEGF), angiopoietin-2 (Ang-2) and laminin in patients with carcinoma cervix therefore need to be explored...
November 26, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
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