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https://www.readbyqxmd.com/read/28439632/a-rat-hysteropexy-model-for-evaluating-adhesion-formation-and-comparison-of-two-different-structured-meshes
#1
Ayse Filiz Gokmen-Karasu, Serdar Aydin, Fatma Cavide Sonmez, Ilknur Adanir, Gulsah Ilhan, Seda Ates
INTRODUCTION AND HYPOTHESIS: Peritonization of mesh during sacrohysteropexy is generally advocated to prevent adhesions to the viscera; however, randomized clinical trials are lacking, and peritonization may not be completely possible in a laparoscopic hysteropexy procedure. Our main objective was to describe a basic experimental rat sacrohysteropexy model. We hypothesized that even when peritoneal closure was omitted, using composite mesh would result in less adhesions to the viscera...
April 24, 2017: International Urogynecology Journal
https://www.readbyqxmd.com/read/28434745/hot-topic-16s-rrna-gene-sequencing-reveals-the-microbiome-of-the-virgin-and-pregnant-bovine-uterus
#2
S G Moore, A C Ericsson, S E Poock, P Melendez, M C Lucy
We tested the hypothesis that the uterus of virgin heifers and pregnant cows possessed a resident microbiome by 16S rRNA gene sequencing of the virgin and pregnant bovine uterus. The endometrium of 10 virgin heifers in estrus and the amniotic fluid, placentome, intercotyledonary placenta, cervical lumen, and external cervix surface (control) of 5 pregnant cows were sampled using aseptic techniques. The DNA was extracted, the V4 hypervariable region of the 16S rRNA gene was amplified, and amplicons were sequenced using Illumina MiSeq technology (Illumina Inc...
April 20, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28429457/surgical-treatment-and-outcome-of-early-invasive-adenocarcinoma-of-the-uterine-cervix-figo-stage-ia1
#3
Hideaki Yahata, Kenzo Sonoda, Masafumi Yasunaga, Tatsuhiro Ohgami, Yoshiaki Kawano, Eisuke Kaneki, Kaoru Okugawa, Tsunehisa Kaku, Kiyoko Kato
AIM: To investigate the surgical outcome of FIGO stage IA1 cervical adenocarcinoma. METHODS: Between 2005 and 2011, 12 patients from Kyushu University Hospital had cervical adenocarcinoma, with a tumor depth of less than 3 mm and a horizontal width of less than 7 mm (FIGO stage IA1), diagnosed by cervical conization. All patients underwent simple hysterectomy or simple trachelectomy with pelvic lymphadenectomy. RESULTS: The mean patient age was 34 years (range, 26-70 years)...
April 21, 2017: Asia-Pacific Journal of Clinical Oncology
https://www.readbyqxmd.com/read/28427752/spontaneously-arising-tumours-and-tumour-like-lesions-of-the-cervix-and-uterus-in-83-pet-guinea-pigs-cavia-porcellus
#4
C Laik-Schandelmaier, R Klopfleisch, S Schöniger, G Weiffenbach, M Staudacher, H Aupperle
Tumours and tumour-like lesions are rare findings in the genital system of guinea pigs. The aim of the present study was to characterize nodular lesions in the cervix and uterus of guinea pigs submitted for histopathological diagnosis. Samples from 83 pet animals were investigated. Cases included 64 surgically excised masses including complete uteri (n = 37), parts from uteri containing masses (n = 8), complete masses (n = 12) or samples from masses (n = 7) and 19 complete necropsy examinations. In 55 of the cases, only solitary changes were observed; in 28 cases two or more lesions were diagnosed...
April 17, 2017: Journal of Comparative Pathology
https://www.readbyqxmd.com/read/28423988/tumor-collision-of-uterine-adenocarcinoma-and-leiomyosarcoma-in-a-goat
#5
Jenna C Dockweiler, Brieuc Cossic, Sean P McDonough, Susan L Fubini, Kayla M Le, Callum G Donnelly, Robert O Gilbert, Soon Hon Cheong
An aged mixed-breed goat doe was presented with a 9-mo history of serosanguineous vaginal discharge. Vaginal speculum examination revealed serosanguineous discharge but otherwise no abnormalities. Transrectal ultrasonography showed normal ovaries and multifocal cystic lesions within the uterus. Ovariohysterectomy was recommended because of a strong suspicion of neoplasia. Multiple, non-resectable masses were noted in and around the uterus intraoperatively, and euthanasia was elected. Autopsy revealed multiple masses within the uterus, cervix, and lung parenchyma...
April 1, 2017: Journal of Veterinary Diagnostic Investigation
https://www.readbyqxmd.com/read/28423971/intrauterine-infection-immune-system-and-premature-birth
#6
Fernanda Rodrigues Helmo, Eduardo Arthur Rodovalho Alves, Renata Alves de Andrade Moreira, Viviane Oliveira Severino, Laura Penna Rocha, Maria Luíza Gonçalves Dos Reis Monteiro, Marlene Antônia Dos Reis, Renata Margarida Etchebehere, Juliana Reis Machado, Rosana Rosa Miranda Corrêa
Preterm birth accounts for nearly one million deaths among children under five years of age, and although its etiopathogenesis is not fully elucidated, ascending intrauterine infection and fetal inflammatory response seem to be the main triggers. The intense inflammatory response mediated by IL-1β, TNF-α, PAF, IFN-γ and IL-6, PGE2 and MMP-1 and MMP-9 causes fetal membrane damage and rupture, increased uterine contractions and biochemical and structural changes in the cervix. Furthermore, preterm neonates have deficient innate and adaptive immune responses characterized by reduced levels of IgG, opsonization and phagocytosis, as well as increased activation of Th1 cells in relation to Th2 cells...
April 20, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28421163/phase-i-trial-of-triapine-cisplatin-paclitaxel-chemotherapy-for-advanced-stage-or-metastatic-solid-tumor-cancers
#7
Charles A Kunos, Edward Chu, Della Makower, Andreas Kaubisch, Mario Sznol, Susan Percy Ivy
Ribonucleotide reductase (RNR) is an enzyme involved in the de novo synthesis of deoxyribonucleotides, which are critical for DNA replication and DNA repair. Triapine is a small-molecule RNR inhibitor. A phase I trial studied the safety of triapine in combination with cisplatin-paclitaxel in patients with advanced stage or metastatic solid tumor cancers in an effort to capitalize on disrupted DNA damage repair. A total of 13 patients with various previously treated cancers were given a 96-h continuous intravenous (i...
2017: Frontiers in Oncology
https://www.readbyqxmd.com/read/28415576/clinicopathological-features-of-small-cell-carcinoma-of-the-uterine-cervix-in-the-surveillance-epidemiology-and-end-results-database
#8
Juan Zhou, San-Gang Wu, Jia-Yuan Sun, Li-Ying Tang, Huan-Xin Lin, Feng-Yan Li, Qiong-Hua Chen, Xin Jin, Zhen-Yu He
To investigate the clinicopathological characteristics and survival of small cell carcinoma of the cervix using Surveillance, Epidemiology, and End Results database. Patients with a diagnosis of small cell carcinoma of the cervix were included between 1988 and 2012. Kaplan-Meier method and Cox regression models were used. A total of 487 patients were included. Of the patients with known International Federation of Gynecology and Obstetrics stage and tumor grade, the stage IV disease was diagnosed in 37.9% patients, and 98...
March 21, 2017: Oncotarget
https://www.readbyqxmd.com/read/28411397/chondrosarcoma-like-metastasis-from-a-poorly-differentiated-uterine-cervical-squamous-cell-carcinoma-a-unique-morphology-and-diagnostic-pitfall-in-cytology
#9
Shohei Ikoma, Marlo Nicolas, Jaishree Jagirdar, Maria Luisa Policarpio-Nicolas
Rare cases of metastatic squamous cell carcinoma with chondroid differentiation from esophageal primary have been reported but none from the uterine cervix. Given the rarity of this phenomenon and potential diagnostic pitfall, we present this unusual case. The patient is a 25-year-old woman who presented with shortness of breath. Computerized tomography (CT) showed several lung and pleural-based nodules. CT-guided core biopsy with touch preparations were performed on the pleural-based nodule. The touch preparations showed large, spindle-to-oval shaped cells with pleomorphic nuclei embedded in metachromatic chondroid stroma...
April 14, 2017: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/28394803/hpv-negative-gastric-type-adenocarcinoma-in-situ-of-the-cervix-a-spectrum-of-rare-lesions-exhibiting-gastric-and-intestinal-differentiation
#10
Karen L Talia, Colin J R Stewart, Brooke E Howitt, Marisa R Nucci, W Glenn McCluggage
In recent years, a number of benign and malignant cervical glandular lesions exhibiting gastric differentiation have been described but premalignant gastric-type lesions have not been well characterized. We report a series of 9 cases of a rare form of cervical adenocarcinoma in situ (AIS) distinguished by gastric and sometimes intestinal differentiation and lack of association with human papillomavirus (HPV) infection. The lesions occurred in women aged 25 to 73 years (mean age 51 y). All cases were located at (or just proximal to) the cervical transformation zone and there was extension to the lower uterine segment in 3 cases, 2 of which also involved the endometrium...
April 7, 2017: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/28389222/cesarean-delivery-in-the-second-stage-of-labor-and-the-risk-of-subsequent-premature-birth
#11
Stephen L Wood, Selphee Tang, Susan Crawford
BACKGROUND: Cesarean delivery is being increasingly used by obstetricians for indicated deliveries in the second stage of labor. Unplanned extension of the uterine incision involving the cervix often occurs with these surgeries. Therefore, we hypothesized that cesarean delivery in the second stage of labor may increase the rate of subsequent spontaneous premature birth. OBJECTIVE: We sought to determine if cesarean delivery in the late first stage of labor or in the second stage of labor increases the risk of a subsequent spontaneous preterm birth...
April 4, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28386466/single-organ-vasculitis-of-the-cervix-accompanying-human-papillomavirus-infection
#12
REVIEW
Murat Gözüküçük, Aslı Yarcı Gürsoy, Duygu Kankaya, Cem Atabekoglu
Single-organ vasculitis (SOV) has rarely been reported to involve the female genital tract but mostly the uterine cervix. A 39-year-old woman was diagnosed to have a high-grade cervical intraepithelial lesion and was treated by large loop excision of the transformation zone. Histopathological evaluation of the excised specimen confirmed the diagnosis of cervical intraepithelial neoplasia grade III accompanied by human papillomavirus infection. The excised second specimen showed the evidence of vasculitis of medium-sized vessels of the cervix, which is a quite rare form of SOV...
June 1, 2016: Interventional Medicine & Applied Science
https://www.readbyqxmd.com/read/28384878/a-rare-collision-tumour-of-uterus-squamous-cell-carcinoma-and-endometrial-stromal-sarcoma
#13
Nadeem Tanveer, Bindiya Gupta, Abhishek Pathre, Shalini Rajaram, Neerja Goyal
Collision tumours are defined by co-existence of two tumours in the same or adjacent organs which are topographically and histologically distinct with minimal or no histological admixture. Collision tumours have been described in many organs notably thyroid, brain, adrenal gland, stomach and rarely uterus. Most of the collision tumours reported in uterus have two components; an adenocarcinoma and a sarcoma. We report a case of a 60-year-old lady who presented with complaints of post-menopausal bleeding. A cervical biopsy was performed which showed a non-keratinizing squamous cell carcinoma of cervix...
February 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28381193/gene-promoter-methylation-and-protein-expression-of-brms1-in-uterine-cervix-in-relation-to-high-risk-human-papilloma-virus-infection-and-cancer
#14
Maria Panagopoulou, Maria Lambropoulou, Ioanna Balgkouranidou, Evangelia Nena, Makrina Karaglani, Christina Nicolaidou, Anthi Asimaki, Theocharis Konstantinidis, Theodoros C Constantinidis, George Kolios, Stylianos Kakolyris, Theodoros Agorastos, Ekaterini Chatzaki
Cervical cancer is strongly related to certain high-risk types of human papilloma virus infection. Breast cancer metastasis suppressor 1 (BRMS1) is a tumor suppressor gene, its expression being regulated by DNA promoter methylation in several types of cancers. This study aims to evaluate the methylation status of BRMS1 promoter in relation to high-risk types of human papilloma virus infection and the development of pre-cancerous lesions and describe the pattern of BRMS1 protein expression in normal, high-risk types of human papilloma virus-infected pre-cancerous and malignant cervical epithelium...
April 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/28381140/proximal-type-epithelioid-sarcoma
#15
David Alfonso Suárez-Zamora, Luis Eduardo Barrera-Herrera, Paula Andrea Rodríguez-Urrego, Mauricio Alfonso Palau-Lázaro
Epithelioid sarcoma is a rare malignant mesenchymal neoplasm (less than 1% of all sarcomas) with epithelioid morphology. Among the 2 subtypes, proximal represents only one-third of cases and commonly involves deep tissues of pelvic region, including the perineum, genital area, and groin, and occurs more frequently in older patients who present a more aggressive course. In the female genital tract, proximal-type epithelioid sarcoma (PES) mainly affects the vulva and is extremely uncommon in the uterus. To our knowledge, only a few cases of PES involving the cervix and uterine body have been previously reported in the literature...
February 1, 2017: International Journal of Surgical Pathology
https://www.readbyqxmd.com/read/28380684/effectiveness-of-photodynamic-therapy-in-elimination-of-hpv-16-and-hpv-18-associated-with-cin-i-in-mexican-women
#16
Elizabeth Maldonado Alvarado, M Olivia Osorio Peralta, Alejandra Moreno Vázquez, L Alejandra Martínez Guzmán, M Eugenia Melo Petrone, Z Iveth Enriquez Mar, D Estela Jovel Galdamez, Bárbara Carrión Solana, Guadalupe Balderas Martínez, Eduarda Parra, R Inés Castellanos Oliveros, R Linda Bello Leiva, Araceli Espinosa Montesinos, Citlalli Barrera Mendoza, S Eugenia Medina García, Eva Ramón Gallegos
The present study aimed to determine the effectiveness of photodynamic therapy (PDT), using δ-aminolevulinic acid (5-ALA), in the elimination of premalignant cervical lesions in Mexican patients with human papillomavirus (HPV) infection and/or cervical intraepithelial neoplasia (CIN). Thirty women diagnosed with CIN I and/or positive for HPV participated in the study. Topical 6% 5-ALA in gel form was applied to the uterine cervix; after 4 h, the lesion area was irradiated with a light dose of 200 J/cm(2) at 635 nm...
April 5, 2017: Photochemistry and Photobiology
https://www.readbyqxmd.com/read/28378614/association-of-fibroblast-growth-factor-receptor-4-genetic-polymorphisms-with-the-development-of-uterine-cervical-cancer-and-patient-prognosis
#17
Tze-Ho Chen, Shun-Fa Yang, Yu-Fan Liu, Wea-Lung Lin, Chih-Ping Han, Po-Hui Wang
This is the first study to investigate the relationships among fibroblast growth factor receptor 4 (FGFR4) genetic polymorphisms, development of uterine cervical cancer, clinicopathological variables, and patient prognosis in Taiwanese women. Real-time polymerase chain reaction and genotyping were used to detect the genotype frequencies of 4 FGFR4 single-nucleotide polymorphisms (SNPs), rs351855 (C/T, Gly388Arg), rs2011077 (G/A), rs7708357 (G/A), and rs1966265 (Ile10Val), in 138 patients with invasive cancer, 89 with precancerous lesions of uterine cervix, and 335 normal controls...
January 1, 2017: Reproductive Sciences
https://www.readbyqxmd.com/read/28376638/transabdominal-collection-of-amniotic-fluid-sludge-and-identification-of-candida-albicans-intra-amniotic-infection
#18
Juan P Kusanovic, Roberto Romero, Carolina Martinovic, Karla Silva, Offer Erez, Eli Maymon, Francisco Díaz, Fernando Ferrer, Rafael Valdés, Víctor Córdova, Paula Vargas, María Elena Nilo, Patricio Le Cerf
A G3P2 patient who conceived with an intrauterine contraceptive device (IUD) presented at 20 weeks of gestation with mild irregular uterine contractions and vaginal bleeding. Sonographic examination at admission showed the presence of dense amniotic fluid "sludge" and a long sonographic uterine cervix (42 mms). To assess the microbiologic significance of amniotic fluid "sludge", we performed a transabdominal amniocentesis. The procedure was performed under real-time ultrasound, and fluid resembling pus at gross examination was noted...
April 5, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28376597/-adenoid-basal-carcinoma-of-uterine-cervix-report-of-a-case
#19
L Y Huang, J X Liu, A L Huang, F Yan
No abstract text is available yet for this article.
April 8, 2017: Zhonghua Bing Li Xue za Zhi Chinese Journal of Pathology
https://www.readbyqxmd.com/read/28370687/mid-trimester-sonographic-cervical-consistency-index-to-predict-spontaneous-preterm-birth-in-a-low-risk-population
#20
Núria Baños, Clara Murillo-Bravo, Carla Julià, Federico Migliorelli, Alvaro Perez-Moreno, Jose Ríos, Eduard Gratacos, Lil Valentin, Montse Palacio
OBJECTIVES: To estimate the ability of mid-trimester sonographic Cervical Consistency Index (CCI) to predict spontaneous preterm birth (sPTB) in low-risk pregnancies and to compare its performance with mid-trimester sonographic cervical length (CL). METHODS: This is a prospective cohort study including women with singleton pregnancies examined with ultrasound at 19 + 0 to 24 + 6 gestational weeks. All underwent transvaginal ultrasound examination of the cervix, but CCI and CL were measured off-line only in women without risk factors for sPTB...
March 31, 2017: Ultrasound in Obstetrics & Gynecology
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