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Masaki Hashimoto, Shigeki Shimizu, Teruhisa Takuwa, Yoshitane Tsukamoto, Tohru Tsujimura, Seiki Hasegawa
BACKGROUND: An atypical type A thymoma variant was newly added to the WHO classification of type A thymoma family in 2015. CASE PRESENTATION: A 72-year-old female was present a large round mass in the anterior mediastinum. The radiological examination led to a preoperative diagnosis of non-invasive thymoma. Tumor resection was undertaken via median sternotomy. Complete removal of the mediastinal tumor was achieved. Pathological examination revealed that the tumor cells were spindle- and oval-shaped with atypia...
December 2016: Surgical Case Reports
Melania Ester Mercado-Pimentel, Craig Miller, Daniela N Rolph, Edrick F Villalobos, Allison M Dunn, Prithvi M Mohan, Suzu Igarashi, Xiangdang Liu, Macken Yrun-Duffy, Neal K Patel, Cecilia M Read, Ross H Francis, Adelina Isabella Lane, Swaroop Murugesh, Abraham Jacob
HYPOTHESIS: p21-activated kinase (PAK) regulates signaling pathways that promote cell survival and proliferation; therefore, pharmacological inhibition of PAK will induce cell death in vestibular schwannomas (VS) and meningiomas. BACKGROUND: All VS and many meningiomas result from loss of the neurofibromatosis type 2 (NF2) gene product merlin, with ensuing PAK hyperactivation and increased cell proliferation/survival. METHODS: The novel small molecule PAK inhibitors PI-8 and PI-15-tested in schwannoma and meningioma cells-perturb molecular signaling and induce cell death...
October 12, 2016: Otology & Neurotology
Hanlu Zhang, Yingcai Geng, Yu Zheng, Yun Wang
A 68-year-old female was admitted to our hospital with an acute episode of chest pain, progressive cough and fever. She underwent trans-subxiphoid video-assisted thoracoscopic extended thymectomy (TsVATET) for thymoma with myasthenia gravis (MG) 9 days ago. Chest computed tomography (CT) showed anterior mediastinal oedema, and infiltrative findings involved bilateral lung. Physical examination revealed the subxiphoid wound suppuration. We diagnosed subxiphoid incision infection, anterior mediastinitis and concomitant bilateral pneumonia...
September 2016: Journal of Thoracic Disease
Priska Leisibach, Didier Schneiter, Alex Soltermann, Yoshi Yamada, Walter Weder, Wolfgang Jungraithmayr
BACKGROUND: Thymic epithelial tumors (TET) are rare neoplasms with inconsistent treatment strategies. When researching for molecular pathways to find new therapies, the correlation between specific molecular markers and outcome has only rarely been investigated. The aim of this study was to investigate the correlation between survival, metastatic potential and invasiveness of aggressive subtypes of TET and immunohistochemical markers. METHODS: Overall survival (OS), disease-free survival (DFS), progression-free survival (PFS) and metastasis-free survival (MFS) of patients with WHO type B2/B3 mixed type thymoma (MT), thymoma type B3 (B3) and thymic carcinoma (TC), undergoing surgery [1998-2013] were determined...
September 2016: Journal of Thoracic Disease
Alberto M Marchevsky, Ann E Walts
The checkpoint protein programmed cell death ligand-1 protein (PD-L1) binds to its receptor (PD-1) activating the PD-L1/PD-1 pathway, an important therapeutic target. There is limited information regarding PD-L1 and PD-1 expression in thymic lesions. Sections from non-neoplastic thymi (n=20), thymomas WHO types A, AB, B1, B2 and B3 (n=38) and thymic squamous cell carcinoma (n=8) were stained for PD-L1 (clone SP142 Spring BioScience), PD-1 (MRQ22 Cell Marque), CD4 (clone SPO32 Cell Marque) and CD8 (JCB117 Ventana)...
October 13, 2016: Human Pathology
Edvina Galié, Rosaria Renna, Domenico Plantone, Andrea Pace, Mirella Marino, Bruno Jandolo, Tatiana Koudriavtseva
Morvan's syndrome (MoS) is a rare, complex neurological disorder characterized by neuromyotonia, neuropsychiatric features, dysautonomia and neuropathic pain. The majority of MoS cases have a paraneoplastic aetiology, usually occurring prior to the diagnosis of the underlying tumour and showing improvement following its treatment. The present study reports the case of a 35-year-old Caucasian male patient who was diagnosed with stage IVA thymoma. Thymectomy, lung resection, diaphragmatic pleurectomy and pericardio-phrenectomy were performed 6 months after neoadjuvant chemotherapy...
October 2016: Oncology Letters
Atiye Seda Yar Saglam, Ebru Alp, Zubeyir Elmazoglu, Emine Sevda Menevse
The activation of the phosphatidylinositol-3 kinase/v-akt murine thymoma viral oncogene homolog (Akt) and mitogen activated protein kinase kinase/extracellular signal-regulated kinase (ERK) pathways are implicated in the majority of cancers. Selective inhibition of Akt and ERK represents a potential approach for cancer therapy. Therefore, the present study aimed to investigate the apoptotic and anti-proliferative effects of the novel and selective Akt inhibitor 4-amino-5,8-dihydro-5-oxo-8-β-D-ribofuranosyl-pyrido[2,3-d]pyrimidine-6-carboxamide (API-1) and selective ERK1/2 inhibitor FR180204 (FR) alone and in combination on colorectal cancer (CRC) cells (DLD-1 and LoVo)...
October 2016: Oncology Letters
Wen-Ta Li, Hui-Wen Chang, Chian-Ren Jeng, Chen-Hsuan Liu, Fun-In Wang, Li-Jen Chang, Victor Fei Pang
An ~21-year-old female Barbary sheep (Ammotragus lervia) died spontaneously following a lengthy episode of difficulty in walking. An ~6 × 3 × 3 cm, unilocular cystic growth was found in the cranioventral thorax. The fibrotic cystic wall, lined by a single layer of flattened to cuboidal epithelial cells, was invaginated and partially encircled solid masses of fusiform neoplastic cells with multiple intratumoral cystic structures. The fusiform neoplastic cells were intensely positive for cytokeratin (CK) and partially positive for α-smooth muscle actin and vimentin, but negative for thyroid transcription factor-1 (TTF-1) and neuron-specific enolase (NSE)...
November 2016: Journal of Veterinary Diagnostic Investigation
John-Ih Lee, Sebastian Jander
Myasthenia gravis is the most frequent acquired disorder of neuromuscular transmission. In the majority of cases, pathogenic antibodies against components of the postsynaptic muscle endplate membrane can be detected. In recent years there have been significant advances in the pathophysiological understanding and therapy of the disease. Areas covered: PubMed searches were conducted for the term "myasthenia gravis" cross-referenced with the terms "immunology", "subgroups", "antibody", "ocular", "thymoma", "treatment" and "thymectomy"...
October 3, 2016: Expert Review of Neurotherapeutics
Ms Jun Du, Qin Shen, Honglin Yin, Qiu Rao, Mr Xiaojun Zhou
MUC1 is a transmembrane mucin that has been related to tumor progression and outcome in various malignancies. GLUT1 is a member of the mammalian facilitative glucose transporter (GLUT) family of passive carriers that functions as an energy-independent system for transporting glucose. Both of them are useful markers for the diagnosis, progression, and prognosis of various tumors, especially those that are cancerous. However, the clinical significance of MUC1 and GLUT1 in thymic epithelial tumors remains uncertain due to a lack of quality specimen and studies at sufficient scale, both owing, in part, to the rarity of the tumors...
September 13, 2016: Pathology, Research and Practice
Jun-Li Tsai, Shang-Feng Tsai
BACKGROUND: Myasthenia gravis superimposed with proteinuria is a very rare disorder with only 39 cases reported so far. Of these cases, the most commonly associated disorder is minimal change disease. Myasthenia gravis and minimal change disease are both related to the dysfunction of T lymphocytes and hence the 2 disorders may be connected. METHODS: Here we report the first case on a patient diagnosed with myasthenia gravis concurrently with the minimal change disease, and it was presented in the absence of thymoma or thymic hyperplasia...
September 2016: Medicine (Baltimore)
Sapan J Patel, Gaurang L Trivedi, Costel C Darie, Bayard D Clarkson
B-cell novel protein-1 (BCNP1) or Family member of 129C (FAM129C) was identified as a B-cell-specific plasma-membrane protein. Bioinformatics analysis predicted that BCNP1 might be heavily phosphorylated. The BCNP1 protein contains a pleckstrin homology (PH) domain, two proline-rich (PR) regions and a Leucine Zipper (LZ) domain suggesting that it may be involved in protein-protein interactions. Using The Cancer Genome Atlas (TCGA) data sets, we investigated the correlation of alteration of the BCNP1 copy-number changes and mutations in several cancer types...
September 29, 2016: Journal of Cellular and Molecular Medicine
M Arias-Álvarez, R M García-García, J López-Tello, P G Rebollar, A Gutiérrez-Adán, P L Lorenzo
In vivo-matured cumulus-oocyte complexes are valuable models in which to assess potential biomarkers of rabbit oocyte quality that contribute to enhanced IVM systems. In the present study we compared some gene markers of oocytes and cumulus cells (CCs) from immature, in vivo-matured and IVM oocytes. Moreover, apoptosis in CCs, nuclear maturation, mitochondrial reallocation and the developmental potential of oocytes after IVF were assessed. In relation to cumulus expansion, gene expression of gap junction protein, alpha 1, 43 kDa (Gja1) and prostaglandin-endoperoxide synthase 2 (Ptgs2) was significantly lower in CCs after in vivo maturation than IVM...
September 28, 2016: Reproduction, Fertility, and Development
Oscar Arrieta, Andrés F Cardona, Luis Corrales-Rodriguez, George Oblitas, Leonardo Rojas, Ludwing Bacon, Claudio Martin, Mauricio Cuello, Luis Mass, Beatriz Wills, Carlos Vargas, Hernán Carranza, Jorge Otero, María Angelina Pérez, Lisde González, Luis Chirinos, Rafael Rosell
No abstract text is available yet for this article.
October 2016: Journal of Thoracic Oncology
Luis Corrales-Rodriguez, Andrés F Cardona, Oscar Arrieta, George Oblitas, Leonardo Rojas, Ludwing Bacon, Claudio Martin, Beatriz Wills, Mauricio Cuello, Luis Mass, Carlos Vargas, Hernán Carranza, Jorge Otero, María Angelina Pérez, Lisde González, Luis Chirinos, Rafael Rosell
No abstract text is available yet for this article.
October 2016: Journal of Thoracic Oncology
Flavio L Cabral, Maria Teresa Ruiz Tsukazan, Jayme O Rios, Jayme R Heck, Gabriel M Schwarcke, Renata M Rosenthal, Maicon J Cimarosti, João R Schmitt, José Antônio Figueiredo Pinto
No abstract text is available yet for this article.
October 2016: Journal of Thoracic Oncology
Giorgio V Scagliotti, Rabab Gaafar, Anna Nowak, Nicholas J Vogelzang, Ute Von Wangenheim, Nassim Morsli, Derek Velema, Sanjay Popat
No abstract text is available yet for this article.
October 2016: Journal of Thoracic Oncology
Naohiro Nose, Kazuhiro Higuchi, Eiichi Chosa, Takanori Ayabe, Masaki Tomita, Kunihide Nakamura
A 60-year-old woman was referred to our hospital with an anterior mediastinal tumor measuring 3.5 cm in diameter on computed tomography (CT). We performed tumor resection by video-assisted thoracic surgery (VATS) with three ports. The final diagnosis was Type A Masaoka Stage I thymoma. On follow-up CT performed 36 months after the operation, two pleural tumors were detected at the port sites through which the forceps and ultrasonic scalpel had passed repeatedly during the operation. We therefore performed a second operation and enucleated the tumors while preserving the ribs...
2016: Journal of Surgical Case Reports
Geoffrey B Johnson, Marie Christine Aubry, Eunhee S Yi, Chi Wan Koo, Sarah M Jenkins, Yolanda I Garces, Randolph S Marks, Stephen D Cassivi, Anja C Roden
INTRODUCTION: Neoadjuvant treatment might increase resectability of thymic epithelial tumors (TET). No standardized pathologic grading scheme for tumor response is available. Also, it is unclear whether radiologic treatment response can predict pathologic response. METHODS: Patients with unresectable TET who underwent neoadjuvant treatment before surgery at Mayo Clinic Rochester (1942-2014) were included. The pathologic tumor response grade (TRG) was based upon Mandard-grading (1994) ranging from TRG 1 (no viable tumor) to TRG 5 (no regression)...
September 22, 2016: Journal of Thoracic Oncology
(no author information available yet)
No abstract text is available yet for this article.
September 20, 2016: Zhongguo Fei Ai za Zhi, Chinese Journal of Lung Cancer
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