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https://www.readbyqxmd.com/read/29218679/possibility-of-women-treated-with-fertility-sparing-surgery-for-non-epithelial-ovarian-tumors-to-safely-and-successfully-become-pregnant-a-chinese-retrospective-cohort-study-among-148-cases
#1
Bin Yang, Yan Yu, Jing Chen, Yan Zhang, Ye Yin, Nan Yu, Ge Chen, Shifei Zhu, Haiyan Huang, Yongqun Yuan, Jihui Ai, Xinyu Wang, Kezhen Li
This study was performed to evaluate the oncological and reproductive outcomes of childbearing-age women treated with fertility-sparing surgery (FSS) for non-epithelial ovarian tumors in China. One hundred and forty eight non-epithelial ovarian tumor women treated with FSS between January 1, 2000 and August 31, 2015 from two medical centers in China were identified. Progression-free survival (PFS) was 88.5%, whereas overall survival (OS) was 93.9%. Univariate analysis suggested that delivery after treatment is related to PFS (P = 0...
December 7, 2017: Frontiers of Medicine
https://www.readbyqxmd.com/read/29198336/fertility-management-for-malignant-ovarian-germ-cell-tumors-patients
#2
REVIEW
Chiara Di Tucci, Assunta Casorelli, Elisa Morrocchi, Innocenza Palaia, Ludovico Muzii, Pierluigi Benedetti Panici
Malignant Germ Cell Tumors have primarily affecting adolescents and young adults. In advanced disease, greater than 70% of patients can be cured with standard chemotherapy regimens and fertility-sparing surgery appears to be safe with excellent survival after long-term follow-up. Due to their rarity, follow up and fertility management is largely based on trials of epithelial ovarian cancer or on few small studies. We report a review of the literature studies about the assessment, the monitoring and the treatment of fertility for Malignant Germ Cell Tumors as pratical guidelines for management of fertility in these patients...
December 2017: Critical Reviews in Oncology/hematology
https://www.readbyqxmd.com/read/29177593/practical-recommendations-for-fertility-preservation-in-women-by-the-fertiprotekt-network-part-i-indications-for-fertility-preservation
#3
A N Schüring, T Fehm, K Behringer, M Goeckenjan, P Wimberger, M Henes, J Henes, M F Fey, M von Wolff
PURPOSE: Most guidelines about fertility preservation are predominantly focused on scientific evidence, but are less practically orientated. Therefore, practically oriented recommendations are needed to support the clinician in daily practice. METHODS: A selective literature search was performed based on the clinical and scientific experience of the authors, focussing on the most relevant diseases and gynaecological cancers. This article (Part I) provides information on topics that are essential for the fertility preservation indication, such as disease prognosis, disease therapy and its associated risks to fertility, recommending disease-specific fertility preservation measures...
November 24, 2017: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/29172287/polycystic-ovarian-morphology-may-be-a-positive-prognostic-factor-in-patients-with-endometrial-cancer-who-achieved-complete-remission-after-fertility-sparing-therapy-with-progestin
#4
Yamato Fukui, Ayumi Taguchi, Katsuyuki Adachi, Marie Sato, Akira Kawata, Michihiro Tanikawa, Kenbun Sone, Mayuyo Mori, Kazunori Nagasaka, Yoko Matsumoto, Takahide Arimoto, Katsutoshi Oda, Yutaka Osuga, Tomoyuki Fujii
Background: The most studied fertility-sparing therapy for endometrial cancer (EC) is oral progestin therapy. However, complete remission (CR) rate after progestin therapy is not enough ranging from 60 to 80 %, with high recurrence rate. Clinical features that predict treatment efficacy and recurrence after progestin therapy have not yet been revealed in detail. The aim of this study was to investigate prognostic factors in patients with EC who achieved CR after medroxyprogesterone acetate (MPA) therapy. Methods: We retrospectively reviewed 35 EC patients treated with MPA at our institution between 2000 and 2016...
November 26, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/29157915/a-call-to-standardize-our-approach-to-fertility-sparing-surgery-in-patients-with-gynecologic-cancers
#5
EDITORIAL
Emeline M Aviki, Nadeem R Abu-Rustum
No abstract text is available yet for this article.
December 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/29146391/small-diameter-hysteroscopic-metroplasty-for-a-septate-uterus-after-open-assisted-laparoscopic-radical-trachelectomy
#6
Akimasa Takahashi, Hiroyuki Kanao, Nobuhiro Takeshima
STUDY OBJECTIVE: To describe a two-step fertility preservation technique for early-stage cervical cancer of a patient with a complete septate uterus. DESIGN: A step-by-step demonstration and explanation of the technique in a surgical video (Canadian Task Force Classification III). SETTING: Center for cancer, a tertiary referral center. The patient provided informed consent to use images and videos of the procedure. Institutional Review Board approval was not required for this kind of procedure...
November 13, 2017: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/29136624/value-of-intraoperative-cytological-and-pathological-sentinel-lymph-node-diagnosis-in-fertility-sparing-trachelectomy-for-early-stage-cervical-cancer
#7
Kenzo Sonoda, Hideaki Yahata, Kaoru Okugawa, Eisuke Kaneki, Tatsuhiro Ohgami, Masafumi Yasunaga, Shingo Baba, Yoshinao Oda, Hiroshi Honda, Kiyoko Kato
BACKGROUND AND OBJECTIVES: Trachelectomy, a fertility-sparing surgery for early-stage cervical cancer, can be performed only when there is no extrauterine extension present. Therefore, identifying the sentinel lymph nodes (SLNs) and using them to obtain an intraoperative pathologic diagnosis can provide information on the feasibility and safety of trachelectomy. Our aim was to assess the value of an intraoperative SLN diagnosis. METHODS: We retrospectively analyzed the accuracy of intraoperative imprint cytology and frozen-section examination in 201 patients at our institution in whom trachelectomy was planned...
November 15, 2017: Oncology
https://www.readbyqxmd.com/read/29128990/erratum-to-fertility-sparing-for-young-patients-with-gynecologic-cancer-how-mri-can-guide-patient-selection-prior-to-conservative-management
#8
Sinead H McEvoy, Stephanie Nougaret, Nadeem R Abu-Rustum, Hebert Alberto Vargas, Elizabeth A Sadowski, Christine O Menias, Fuki Shitano, Shinya Fujii, Ramon E Sosa, Joanna G Escalon, Evis Sala, Yulia Lakhman
The original version of this article unfortunately contained mistakes. The figures 7D, 7E and 7F were missing in the article and arrows were missing in the figures 6C, 8B and 11C. The year of publication and volume number for references 19, 79 and 87 have been updated. Also, the Table 2 layout has been improved for better readability. The Publisher apologizes for the mistakes and the inconvenience caused.
November 11, 2017: Abdominal Radiology
https://www.readbyqxmd.com/read/29121416/pregnant-outcomes-of-atypical-polypoid-adenomyoma-treated-with-progestin-therapy
#9
Qin Chen, Weiguo Lu, Bingjian Lu
AIM: We aimed to investigate the long-term clinical and pregnancy outcome in patients with atypical polypoid adenomyoma (APA) after hysteroscopic excision. METHODS: We analyzed the clinicopathological features, including pregnancy outcomes, in 10 APA patients who had been treated with hysteroscopic excision of the lesion and progesterone therapy. RESULTS: The patients were all nulliparous, and nine had been clinically diagnosed as infertile...
November 9, 2017: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/29119739/fertility-outcomes-in-infertile-women-with-complex-hyperplasia-or-complex-atypical-hyperplasia-who-received-progestin-therapy-and-in-vitro-fertilization
#10
Miao Li, Jia-Lun Song, Ying Zhao, She-Ling Wu, Hong-Bin Liu, Rong Tang, Lei Yan
This study aimed to evaluate fertility and oncologic outcomes in women with complex hyperplasia (CH) or complex atypical hyperplasia (CAH) who received fertility-sparing therapy and in vitro fertilization (IVF). Endometrial carcinoma is the most common carcinoma of the female genital tract, and is associated with endometrial hyperplasia (EH) resulting from long-term unopposed estrogenic stimulation of the endometrium. EH is characterized by non-physiological proliferation of endometrium that results in glands with irregular shapes and varying sizes...
2017: Journal of Zhejiang University. Science. B
https://www.readbyqxmd.com/read/29069949/fertility-sparing-surgery-in-epithelial-ovarian-cancer-in-italy-perceptions-practice-and-main-issues
#11
Alice Bergamini, Micaela Petrone, Emanuela Rabaiotti, Francesca Pella, Raffaella Cioffi, Elena Giulia Rossi, Valentina Di Mattei, Massimo Candiani, Giorgia Mangili
About 2.7% of patients epithelial ovarian cancers (EOC) are younger than 40 and present with stage I disease. For this subset of women, the issue of fertility sparing surgery (FSS) has become critical. The aim of this survey was to investigate the management of EOC patients desiring to preserve fertility in Italy. A questionnaire consisting of 30 items was developed to evaluate: patient-selection criteria, rate of FSS, patient's counseling- and pregnancy-timing, fertility preservation, obstetrics, and oncologic outcomes...
October 26, 2017: Gynecological Endocrinology
https://www.readbyqxmd.com/read/29056645/fertility-lost-fertility-found-narratives-from-the-leading-edge-of-oncofertility
#12
Teresa K Woodruff
A cancer diagnosis at a young age creates one of the most existential crises one can imagine. The good news is that for many of these young patients, they will survive their diagnosis. They will be told of the side effects of treatment including loss of hair but will not be told of the other losses associated with their reproductive function-loss of menstrual cycles, early menopause and the potential for pregnancy for women, loss of viable sperm for men, and loss of sexual libido in both cases. Not all cancer treatments result in the same series of fertility effects so one of the issues that physicians face is determining what the best course of fertility sparing options should be...
2017: Narrative Inquiry in Bioethics
https://www.readbyqxmd.com/read/29032256/real-time-fluorescent-sentinel-lymph-node-mapping-with-indocyanine-green-in-women-with-previous-conization-undergoing-laparoscopic-surgery-for-early-invasive-cervical-cancer-comparison-with-radiotracer%C3%A2-%C3%A2-%C3%A2-blue-dye
#13
Alessandro Buda, Andrea Papadia, Giampaolo Di Martino, Sara Imboden, Beatrice Bussi, Luca Guerra, Elena De Ponti, Claudio Reato, Maria Luisa Gasparri, Cinzia Crivellaro, Michael Mueller
STUDY OBJECTIVE: To evaluate the added value of the fluorescence dye indocyanine green (ICG) for sentinel lymph node (SLN) mapping in women with cervical cancer who had undergone previous conization (stage 1A-1B1) by comparing ICG versus Tc99m radiotracer + blue dye (BD). DESIGN: Retrospective study (Canadian Task Force classification II-2). SETTING: Two European academic medical centers, San Gerardo Hospital, Italy and University of Berne, Switzerland...
October 12, 2017: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/29027405/safety-of-fertility-sparing-surgery-for-stage-i-ovarian-clear-cell-carcinoma
#14
EDITORIAL
Jeong Yeol Park
No abstract text is available yet for this article.
November 2017: Journal of Gynecologic Oncology
https://www.readbyqxmd.com/read/29022007/is-uterine-preservation-combined-with-bilateral-salpingo-oophorectomy-to-promote-subsequent-fertility-safe-in-infiltrative-mucinous-ovarian-cancer
#15
Sebastien Gouy, Marine Saidani, Amandine Maulard, Matthieu Faron, Slim Bach-Hamba, Enrica Bentivegna, Alexandra Leary, Patricia Pautier, Mojgan Devouassoux-Shisheboran, Catherine Genestie, Philippe Morice
According to the latest World Health Organization classification (2014), mucinous ovarian cancers should be classified histologically as being either expansile or infiltrative. Compared to other epithelial cancers, both of these mucinous patterns are diagnosed, in the main, at an early stage, although they can affect relatively young patients. The infiltrative subtype is characterized by a morphologically and clinically more aggressive disease versus the expansile form. Consequently, even in young patients who would prefer fertility sparing management, the removal of both ovaries (even for a unilateral tumor) remains a common recommendation...
November 2017: Gynecologic Oncology Reports
https://www.readbyqxmd.com/read/28986185/fertility-sparing-management-using-progestin-for-young-women-with-endometrial-cancer-from-a-population-based-study
#16
Soyoun Rachel Kim, Carlijn van der Zanden, Habibe Ikiz, Boris Kuzelijevic, Jon Havelock, Janice S Kwon
OBJECTIVE: For young women with complex atypical endometrial hyperplasia (CAH) and endometrial cancer (EC) who choose to preserve fertility, progestin therapy is the mainstay of treatment. The objective of this study was to evaluate oncologic and reproductive outcomes associated with progestin therapy among these women from a population-based cancer registry. METHODS: This was a retrospective population-based cohort study of women under age 45 in British Columbia from 2003 to 2015 with CAH or grade I endometrioid EC who used progestins as initial management...
October 3, 2017: Journal of Obstetrics and Gynaecology Canada: JOGC, Journal D'obstétrique et Gynécologie du Canada: JOGC
https://www.readbyqxmd.com/read/28982877/the-impact-of-surgical-staging-on-the-prognosis-of-mucinous-borderline-tumors-of-the-ovaries-a-multicenter-study
#17
MULTICENTER STUDY
Kemal Gungorduk, Osman Asicioglu, Elena Ioana Braicu, Jumana Almuheimid, Sevki Goksun Gokulu, Nilufer Cetinkaya, Tayfun Gungor, Gonca Pakay, Elcin Uzmez Telli, Zeliha Firat Cuylan, Tayfun Toptas, Ahmet Bilgi, Ramazan Ozyurt, Elif Agacayak, Aykut Ozdemir, Nuri Yildirim, Salih Taskin, Tufan Oge, Onur Erol, Levent Akman, Anil Turan, Mehmet Sait Icen, Taylan Senol, Ozlem Irak Ovali, Burcu Yucesoy, Ozgu Gungorduk, Osman Temizkan, Muzaffer Sanci, Tayup Simsek, Mehmet Mutlu Meydanli, Mehmet Harma, Levent Yasar, Aysel Derbent Uysal, Ates Karateke, Firat Ortac, Sabit Sinan Ozalp, Jalid Sehouli, Mustafa Zelal Muallem
BACKGROUND/AIM: The purpose of this study was to prove the effect of complete surgical staging of patients with mucinous borderline ovarian tumors (mBOTs) especially appendectomy on progression-free survival (PFS) and overall survival (OS). PATIENTS AND METHODS: The database of 14 gynecological oncology departments from Turkey and Germany were comprehensively searched for women who underwent primary surgery for an ovarian tumor between January 1, 1998, and December 31, 2015, and whose final diagnosis was mBOT...
October 2017: Anticancer Research
https://www.readbyqxmd.com/read/28969219/giving-birth-after-fertility-sparing-treatment-for-a-yolk-sac-tumour-case-report
#18
Georgios-Marios Makris, Alexandros Fotiou, Georgios Chrelias, Marco-Johannes Battista, Charalampos Chrelias
Yolk Sac Tumours (YSTs) of the ovary, also called Endodermal Sinus Tumours (ESTs), are the second most common Malignant Ovarian Germ Cell Tumours (MOGCTs), after dysgerminomas. YSTs occur primarily in children and young women. We present a case report of a 20-year-old woman who had been diagnosed with YST (tumour diameter of 29 cm). The patient underwent fertility sparing surgery and was subsequently treated with adjuvant chemotherapy (four cycles of bleomycin, etoposide and cisplatin). Two years after the diagnosis of YST, she successfully gave birth to a healthy girl (birth weight 3,500 g, Apgar score of 9-10 and a spontaneous vaginal delivery)...
August 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28941656/factors-influencing-fertility-sparing-treatment-for-gynecologic-malignancies-a-survey-of-society-of-gynecologic-oncology-members
#19
Jaimin S Shah, Rosa Guerra, Diane C Bodurka, Charlotte C Sun, Gary B Chisholm, Terri L Woodard
OBJECTIVES: This study aims to examine practice patterns of gynecologic oncologists (GO) regarding fertility-sparing treatments (FST) for gynecology malignancies and explores attitudes toward collaboration with reproductive endocrinologists (RE). METHODS: An anonymous 23-question survey was sent to 1087 GO with a 14.0% completion rate. Descriptive statistics, Fisher's exact test, and Chi-square tests were used for data analysis. RESULTS: The majority of GOs offer FST for gynecologic malignancies...
September 21, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/28930805/the-value-of-diffusion-weighted-imaging-in-combination-with-conventional-magnetic-resonance-imaging-for-improving-tumor-detection-for-early-cervical-carcinoma-treated-with-fertility-sparing-surgery
#20
Xiulei Li, Ling Wang, Yong Li, Peiji Song
OBJECTIVE: This study aimed to investigate the value of diffusion-weighted imaging (DWI) in combination with conventional magnetic resonance imaging (MRI) for improving tumor detection in young patients treated with fertility-sparing surgery because of early cervical carcinoma. METHODS: Fifty-four patients with stage Ia or Ib1 cervical carcinoma were enrolled into this study. Magnetic resonance examinations were performed for these patients using conventional MRI (including T1-weighted imaging, T2-weighted imaging, and dynamic contrast-enhanced MRI) and DWI...
October 2017: International Journal of Gynecological Cancer
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