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https://www.readbyqxmd.com/read/29690868/oncological-and-reproductive-outcomes-of-adenocarcinoma-in-situ-of-the-cervix-managed-with-the-loop-electrosurgical-excision-procedure
#1
Huimin Bai, Jun Liu, Qiuxi Wang, Ying Feng, Tong Lou, Shuzhen Wang, Yue Wang, Mulan Jin, Zhenyu Zhang
BACKGROUND: The standard treatment for cervical adenocarcinoma in situ (AIS) is hysterectomy, which is a more aggressive treatment than that used for squamous intraepithelial lesions. Several previous studies have primarily demonstrated that the loop electrosurgical excision procedure (LEEP) is as safe and effective as cold knife cone (CKC) biopsy when AIS is unexpectedly found in a loop excision. This study evaluated the safety of LEEP as the initial treatment for patients with AIS who were strictly selected and evaluated before and after loop resection...
April 24, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29688967/the-european-society-of-gynaecological-oncology-european-society-for-radiotherapy-and-oncology-european-society-of-pathology-guidelines-for-the-management-of-patients-with-cervical-cancer
#2
David Cibula, Richard Pötter, François Planchamp, Elisabeth Avall-Lundqvist, Daniela Fischerova, Christine Haie Meder, Christhardt Köhler, Fabio Landoni, Sigurd Lax, Jacob Christian Lindegaard, Umesh Mahantshetty, Patrice Mathevet, W Glenn McCluggage, Mary McCormack, Raj Naik, Remi Nout, Sandro Pignata, Jordi Ponce, Denis Querleu, Francesco Raspagliesi, Alexandros Rodolakis, Karl Tamussino, Pauline Wimberger, Maria Rosaria Raspollini
BACKGROUND: Despite significant advances in the screening, detection, and treatment of preinvasive cervical lesions, invasive cervical cancer is the fifth most common cancer in European women. There are large disparities in Europe and worldwide in the incidence, management, and mortality of cervical cancer. OBJECTIVE: The European Society of Gynaecological Oncology (ESGO), the European Society for Radiotherapy and Oncology (ESTRO), and the European Society of Pathology (ESP) jointly develop clinically relevant and evidence-based guidelines in order to improve the quality of care for women with cervical cancer across Europe and worldwide...
May 2018: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/29685481/survival-of-selected-patients-with-ovarian-cancer-treated-with-fertility-sparing-surgery
#3
Nora Elisabeth Hedbäck, Mona Aarenstrup Karlsen, Claus Kim Høgdall, Mikkel Rosendahl
RESEARCH QUESTION: How many patients in Denmark were treated with fertility-sparing surgery (FSS) for epithelial ovarian cancer (EOC) and what was their prognosis compared with patients treated with radical surgery (RS)? DESIGN: This study was a retrospective Danish nationwide study, evaluating the effect of FSS compared with RS in patients with EOC, age ≤45 years and International Federation of Gynecology and Obstetrics (FIGO) stage ≤IC3 from 2005 to 2016. RESULTS: A total of 106 patients were included...
April 11, 2018: Reproductive Biomedicine Online
https://www.readbyqxmd.com/read/29628615/pelvic-artery-embolization-for-treatment-of-postpartum-hemorrhage
#4
REVIEW
Jonathan D Lindquist, Robert L Vogelzang
Postpartum hemorrhage (PPH) is the leading cause of maternal perinatal morbidity and mortality worldwide. Defined as greater than 500 mL blood loss after vaginal delivery, and greater than 1,000 mL blood loss after cesarean delivery, PPH has many causes, including uterine atony, lower genital tract lacerations, coagulopathy, and placental anomalies. Correction of coagulopathy and identification of the cause of bleeding are mainstays of treatment. Medical therapies such as uterotonics, balloon tamponade, pelvic artery embolization, and uterine-sparing surgical options are available...
March 2018: Seminars in Interventional Radiology
https://www.readbyqxmd.com/read/29609031/laparoscopic-ligation-of-uterine-vasculature-for-fertility-sparing-management-of-postabortal-hemorrhage
#5
Gulden Menderes, Daisy Leon-Martinez, Masoud Azodi
No abstract text is available yet for this article.
March 30, 2018: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/29593997/hereditary-leiomyomatosis-and-renal-cell-cancer-cutaneous-lesions-atypical-fibroids
#6
Pietro Bortoletto, Jennifer L Lindsey, Liping Yuan, Bradley J Quade, Antonio R Gargiulo, Cynthia C Morton, Elizabeth A Stewart, Raymond M Anchan
Objective: To report a diagnosis of hereditary leiomyomatosis and renal cell cancer (HLRCC) syndrome following initial presentation with multiple cutaneous lesions. Design: Case report. Design classification: N/A. Setting: Academic tertiary care center. Patients: 27-year-old nulligravid woman who presented with multiple red-brown lesions on her skin found to have cutaneous and uterine leiomyoma...
July 2017: Case Reports in Women's Health
https://www.readbyqxmd.com/read/29563810/clinicopathological-characteristics-and-prognosis-of-adult-ovarian-granulosa-cell-tumor-a-single-institution-experience-in-china
#7
Dan Wang, Yang Xiang, Ming Wu, Keng Shen, Jiaxin Yang, Huifang Huang, Tong Ren
Objectives: We aimed to demonstrate the clinical characteristics and risk factors associated with recurrence of adult granulosa cell tumor (AGCT), as well as the pregnancy and long-term outcomes among patients in a single institution in China. Patients and methods: We reviewed 141 patients with AGCT in Peking Union Medical College Hospital between January 1983 and September 2015. Results: The mean patient age was 45.1 years (16-78 years), and the mean tumor size was 8...
2018: OncoTargets and Therapy
https://www.readbyqxmd.com/read/29557823/patterns-of-care-for-stage-ia-cervical-cancer-use-of-definitive-radiation-therapy-versus-hysterectomy
#8
Jeffrey M Ryckman, Chi Lin, Charles B Simone, Vivek Verma
OBJECTIVE: The standard of care for clinical IA cervical cancer is surgery, but nonoperative cases may receive definitive radiation therapy (RT). Herein, we investigated national practice patterns associated with the administration of definitive RT as compared with hysterectomy-based surgery (HYS) as well as delivery of adjuvant RT after HYS. METHODS/MATERIALS: The National Cancer Data Base (NCDB) was queried for clinical IA primary cervical cancer cases (2004-2013) receiving definitive RT or HYS with or without adjuvant RT...
March 20, 2018: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/29550815/incidence-and-risk-profile-of-dementia-in-the-regions-of-middle-east-and-north-africa
#9
Devender Bhalla, Elham Lotfalinezhad, Fatemah Amini, Mohsen Salmannejad, Vahid Reza Borhani Nezhad, Seyedeh Fatemeh Rezai Kooshalshah, Ahmed Delbari, Reza Fadayevatan, I Irmansyah, Abdalla Abdelrahman, Nanda Kumar Bhatta, Kurosh Gharagozli
BACKGROUND: The risk of dementia is reported as "epidemic" and "looming" over the Middle East and North Africa (MENA) region. For this, we performed a multi-language review and feasible analysis on the incidence of dementia to offer apt conclusions. METHODS: Totally, 3 databases (Magiran, Scientific Information Database, and PubMed) and 1 non-database source (Google) were searched in French, English, and Persian by using specific keywords and their combinations...
March 14, 2018: Neuroepidemiology
https://www.readbyqxmd.com/read/29538257/obstetric-outcomes-in-women-with-early-bulky-cervical-cancer-downstaged-by-neoadjuvant-chemotherapy-to-allow-for-fertility-sparing-surgery-a-meta-analysis-and-metaregression
#10
Alexandros Laios, Jenneke Kasius, Anastasios Tranoulis, Alexandros Gryparis, Thomas Ind
OBJECTIVE: It is difficult to critically outline the optimal treatment for women with early-stage cervical cancer (eCC) wishing fertility preservation. Neoadjuvant chemotherapy (NAC) to downstage "bulky" eCC could potentially lead to fertility-sparing surgery (FSS) in a wider patient population. The rationale is to provide oncological safety balanced with maximal fertility effort. We aimed to obtain the most accurate fertility outcomes for eCC women treated with NAC followed by FSS and identify potential factors favoring fertility...
March 14, 2018: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/29533020/insulin-resistance-and-overweight-prolonged-fertility-sparing-treatment-duration-in-endometrial-atypical-hyperplasia-patients
#11
Bingyi Yang, Liying Xie, Hongwei Zhang, Qin Zhu, Yan Du, Xuezhen Luo, Xiaojun Chen
OBJECTIVE: Our previous study showed that insulin resistance (IR) was related to endometrial hyperplasia as well as endometrial cancer. But the exact impact of IR on fertility-sparing treatment in endometrial hyperplasic disease is unclear. This study investigated how IR affects fertility-sparing treatment in endometrial atypical hyperplasia (EAH) patients. METHODS: The 151 EAH patients received fertility-sparing treatment were retrospectively investigated. All patients received high-dose progestin combined with hysteroscopy...
February 19, 2018: Journal of Gynecologic Oncology
https://www.readbyqxmd.com/read/29530784/testis-sparing-surgery-for-benign-testicular-masses-diagnostics-and-therapeutic-approaches
#12
Pia Paffenholz, Linn Held, Sven H Loosen, David Pfister, Axel Heidenreich
PURPOSE: Small benign testicular masses are often misinterpreted as germ cell tumors, and immediate inguinal orchiectomy is performed. We aimed to analyse the diagnostic and therapeutic work-up of testicular masses in order to improve preoperative stratification algorithms. MATERIALS AND METHODS: We performed a retrospective, single-center analysis of 522 patients diagnosed with primary testicular masses of unknown malignant potential. RESULTS: 28 (5%) patients showed a primary benign tumor after resection: 9 (32%) Leydig cell tumors, 9 (32%) epidermoid cysts, 8 (29%) adenomatoid tumors and 2 (7%) Sertoli cell tumors...
March 9, 2018: Journal of Urology
https://www.readbyqxmd.com/read/29527850/use-of-aromatase-inhibitors-in-ivf-for-fertility-preservation-of-non-breast-cancer-patients-a-case-series
#13
Avi Ben-Haroush, Irit Ben-Aharon, Yechezkel Lande, Benjamin Fisch
BACKGROUND: Controlled ovarian hyperstimulation (COH) followed by oocyte retrieval is a leading option for fertility preservation before chemotherapy, yet this procedure causes excessive serum levels of estradiol (E2), which are often detrimental for cancer patients. Aromatase inhibitors are often used in breast cancer patients during COH to prevent elevated levels of E2. OBJECTIVES: To describe our experience with COH for oocyte cryopreservation in non-breast cancer patients using aromatase inhibitors...
March 2018: Israel Medical Association Journal: IMAJ
https://www.readbyqxmd.com/read/29506849/disparities-in-fertility-sparing-surgery-in-adolescent-and-young-women-with-stage-i-ovarian-dysgerminoma
#14
Laura L Stafman, Ilan I Maizlin, Matthew Dellinger, Kenneth W Gow, Melanie Goldfarb, Jed G Nuchtern, Monica Langer, Sanjeev A Vasudevan, John J Doski, Adam B Goldin, Mehul Raval, Elizabeth A Beierle
BACKGROUND: In many cancers, racial and socioeconomic disparities exist regarding the extent of surgery. For ovarian dysgerminoma, fertility-sparing (FS) surgery is recommended whenever possible. The aim of this study was to investigate rates of FS versus non-fertility-sparing (NFS) procedures for stage I ovarian dysgerminoma in adolescents and young adults (AYAs) by ethnicity/race and socioeconomic status. MATERIALS AND METHODS: The National Cancer Data Base was queried for patients with ovarian dysgerminoma from 1998 to 2012...
April 2018: Journal of Surgical Research
https://www.readbyqxmd.com/read/29480840/clinical-management-of-a-unique-case-of-pnet-of-the-uterus-during-pregnancy-and-review-of-the-literature
#15
REVIEW
Rosalba De Nola, Edoardo Di Naro, Luca Maria Schonauer, Giuseppe Lucarelli, Michele Battaglia, Maria Grazia Fiore, Salvatore Andrea Mastrolia, Giuseppe Loverro
RATIONALE: PNETs (primitive neuroectodermal tumors) are a family of highly malignant neoplasms characterized by small round cells of neuroepithelial origin. They usually involve bone and soft tissues, and have a higher incidence in childhood. PATIENT CONCERNS: In this case report, we describe the obstetric and oncological outcome of a huge mass diagnosed as a leiomyoma in a 39-year-old pregnant woman who complained of low back pain, dysuria, and urinary frequency at 22 weeks of gestation...
January 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29476421/immunosuppression-in-pregnant-women-with-renal-disease-review-of-the-latest-evidence-in-the-biologics-era
#16
REVIEW
Loredana Colla, Davide Diena, Maura Rossetti, Ana Maria Manzione, Luca Marozio, Chiara Benedetto, Luigi Biancone
Care of pregnant woman, including fertility and procreation counseling, has become a significant part of the nephrological practice in the last years. In this context, the management of immunosuppression assumes a primary role both for autoimmune diseases and for post-transplant follow up. The present review analyzes the latest evidence on immunosuppressive drugs of current use in nephrology and kidney transplantation. Although the placenta inactivates prednisone and prednisolone, it is advisable to limit the dose to the minimal effective one, to prevent side effects...
February 23, 2018: Journal of Nephrology
https://www.readbyqxmd.com/read/29463755/crop-intensification-land-use-and-on-farm-energy-use-efficiency-during-the-worldwide-spread-of-the-green-revolution
#17
Pedro Pellegrini, Roberto J Fernández
We analyzed crop production, physical inputs, and land use at the country level to assess technological changes behind the threefold increase in global crop production from 1961 to 2014. We translated machinery, fuel, and fertilizer to embedded energy units that, when summed up, provided a measure of agricultural intensification (human subsidy per hectare) for crops in the 58 countries responsible for 95% of global production. Worldwide, there was a 137% increase in input use per hectare, reaching 13 EJ, or 2...
February 20, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29461339/neoadjuvant-bleomycin-etoposide-and-cisplatin-bep-chemotherapy-in-the-treatment-of-extensively-advanced-yolk-sac-tumors-a-single-center-experience
#18
Gong-Yi Zhang, Rong Zhang, Ling-Ying Wu, Bin Li, Shu-Min Li
OBJECTIVE: This study aimed to investigate the role of neoadjuvant bleomycin, etoposide, and cisplatin (BEP) regimen in patients with extensively advanced yolk sac tumors (YSTs). METHODS: Between July 1982 and December 2015, a total of 58 patients with YST were initially treated at our institution, among which 18 were evaluated to be inoperable and received neoadjuvant BEP regimen. They were either too debilitated by the disease [Eastern Cooperative Oncology Group Performance Status Scale (ECOG ps) ≥2] to undergo a major surgery or were with too extensively disseminated lesions to be optimally debulked...
February 15, 2018: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/29402199/fertility-sparing-treatment-of-adenomyosis-in-patients-with-infertility-a-systematic-review-of-current-options
#19
Tainá Pezzin Rocha, Marina Paula Andres, Giuliano Moysés Borrelli, Mauricio Simões Abrão
Adenomyosis is a benign gynecological disease observed in women in their reproductive age. Recent studies have shown that adenomyosis might be a relevant factor for infertility, either impairing implantation or leading to early miscarriage. However, conservative treatment of infertility related to adenomyosis is still unclear. This study systematically reviews the literature for the reproductive outcomes of the available conservative treatments for patients with adenomyosis-associated infertility. We conducted a search in PubMed/Medline for studies in English published in the last 7 years and included 16 studies...
January 1, 2018: Reproductive Sciences
https://www.readbyqxmd.com/read/29402157/alternative-approaches-to-surgical-hemostasis-in-patients-with-morbidly-adherent-placenta-undergoing-fertility-sparing-surgery
#20
Roman G Shmakov, Aleksandr A Vinitskiy, Vladimir D Chuprinin, Ekaterina L Yarotskaya, Gennady T Sukhikh
AIM: To evaluate the efficacy of different methods of surgical hemostasis, including the ligation of internal iliac arteries (IIA), temporary occlusion of the common iliac artery (CIA) and combined compression hemostasis, during cesarean section in patients with morbidly adherent placenta (MAP). MATERIALS AND METHODS: The study included 54 patients with MAP. All patients underwent cesarean section with application of surgical hemostasis techniques. In Group 1 (n = 15), ligation of IIA was performed, in Group 2 (n = 18) extravasal temporary occlusion of CIA, and in Group 3 (n = 21) combined compression hemostasis was applied...
February 5, 2018: Journal of Maternal-fetal & Neonatal Medicine
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