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https://www.readbyqxmd.com/read/27909687/morphogenesis-of-human-embryonic-stem-cells-into-mature-neurons-under-in-vitro-culture-conditions
#1
Geeta Shroff
AIM: To describe the morphogenesis of different neuronal cells from the human embryonic stem cell (hESC) line, SCT-N, under in vitro culture conditions. METHODS: The directed neuronal cell line was produced from a single, spare, pre-implantation stage fertilized ovum that was obtained during a natural in vitro fertilization process. The hESCs were cultured and maintained as per our proprietary in-house technology in a Good Manufacturing Practice, Good Laboratory Practice and Good Tissue Practice compliant laboratory...
November 20, 2016: World Journal of Experimental Medicine
https://www.readbyqxmd.com/read/27909567/ovarian-reserve-may-be-compromised-after-adnexal-surgery-are-we-sufficiently-fertility-focused-in-our-surgical-training
#2
G S Kalra, S Campbell, G Nargund
There is a general trend towards delay in childbearing age amongst women. The ovarian reserve clearly falls with increasing age and the impact is greater with advancing age, particularly from late 30s. Presence of other risk factors can increase the risk of subfertility. A large number of women are exposed to pelvic surgery for various reasons, both elective and emergency. There is evidence that some of the pelvic surgery performed around ovaries and tubes has a negative impact on the ovarian reserve and in turn may cause a decline in woman's ability to conceive...
June 27, 2016: Facts, Views & Vision in ObGyn
https://www.readbyqxmd.com/read/27904170/twenty-five-year-old-woman-with-bilateral-borderline-ovarian-tumour-desiring-to-preserve-fertility-case-report-and-literature-review-on-the-current-state-of-fertility-preservation-in-women-with-borderline-ovarian-tumours
#3
S Findeklee, L Lotz, K Heusinger, I Hoffmann, R Dittrich, M W Beckmann
Borderline ovarian tumours are semimalignant tumours occurring unilaterally or bilaterally with a peak incidence among women of reproductive age. Since the affected women often wish to preserve fertility, particular precautions must be taken when counselling the patient and obtaining consent prior to planning an individual treatment. Options for preserving fertility include an organ-sparing surgical procedure and cryopreservation of oocytes and/or ovarian tissue. In this article, we report on a 25-year-old patient with a bilateral seromucinous borderline tumour who desired all fertility-preserving options...
November 2016: Geburtshilfe und Frauenheilkunde
https://www.readbyqxmd.com/read/27898793/increasing-soluble-phosphate-species-by-treatment-of-phosphate-rocks-with-acidic-waste
#4
Wedisson O Santos, Dean Hesterberg, Edson M Mattiello, Leonardus Vergütz, Matheus S C Barreto, Ivo R Silva, Luiz F S Souza Filho
The development of efficient fertilizers with a diminished environmental footprint will help meet the increasing demand for food and nutrients by a growing global population. Our objective was to evaluate whether an acidic mine waste (AMW) could be used beneficially by reacting it with sparingly soluble phosphate rocks (PRs) to produce more soluble P fertilizer materials. Three PRs from Brazil and Peru were reacted with different concentrations of AMW. Changes in mineralogy and P species were determined using a combination of X-ray diffraction and phosphorus K-edge XANES spectroscopy, in addition to extractable P concentrations...
November 2016: Journal of Environmental Quality
https://www.readbyqxmd.com/read/27896308/small-cell-ovarian-carcinoma-long-term-survival-in-juvenile-case-with-poor-prognostic-features
#5
Lauren Stewart, Ruchi Garg, Rochelle Garcia, Elizabeth Swisher
BACKGROUND: Ovarian small cell carcinoma is a rare, aggressive neoplasm that occurs in young women and has a poor long-term prognosis. Treatment involves surgical resection and chemotherapy. The required radicality of surgery is uncertain, balancing cytoreduction with fertility preservation. Various chemotherapy regimens are utilized due to confusion regarding the neoplasm's lineage. Case We describe an adolescent with small cell carcinoma, hypercalcemic type, stage IA. Surgery included left salpingo-oopherectomy, left pelvic/paraaortic lymphadenectomy, omentectomy and peritoneal biopsies...
November 2016: Gynecologic Oncology Reports
https://www.readbyqxmd.com/read/27894168/hysteroscopy-in-fertility-sparing-management-for-early-endometrial-cancer-a-double-edged-sword
#6
EDITORIAL
Jeong Yeol Park
No abstract text is available yet for this article.
November 17, 2016: Journal of Gynecologic Oncology
https://www.readbyqxmd.com/read/27890492/treatment-of-leydig-cell-tumours-of-the-testis-can-testis-sparing-surgery-replace-radical-orchidectomy-results-of-a-systematic-review
#7
G Bozzini, D Ratti, L Carmignani
INTRODUCTION: The gold standard for Leydig cell tumours (LCTs) is still considered radical orchidectomy, but testis sparing surgery (TSS) in conjunction with intraoperative frozen section (FSE) has been recently attempted with promising results. ACQUISITION OF EVIDENCE: Studies were identified by searching electronic databases. A bibliographic search covering the period from January 1980 to December 2012 was conducted using PubMed/MEDLINE and EMBASE database. Studies were excluded if they were single case reports, meeting abstracts and conference proceedings...
November 24, 2016: Actas Urologicas Españolas
https://www.readbyqxmd.com/read/27853605/closing-oil-palm-yield-gaps-among-indonesian-smallholders-through-industry-schemes-pruning-weeding-and-improved-seeds
#8
T Soliman, F K S Lim, J S H Lee, L R Carrasco
Oil palm production has led to large losses of valuable habitats for tropical biodiversity. Sparing of land for nature could in theory be attained if oil palm yields increased. The efficiency of oil palm smallholders is below its potential capacity, but the factors determining efficiency are poorly understood. We employed a two-stage data envelopment analysis approach to assess the influence of agronomic, supply chain and management factors on oil palm production efficiency in 190 smallholders in six villages in Indonesia...
August 2016: Royal Society Open Science
https://www.readbyqxmd.com/read/27831834/role-of-imaging-in-fertility-sparing-treatment-of-gynecologic-malignancies
#9
Andrea G Rockall, Mahrukh Qureshi, Ioanna Papadopoulou, Srdjan Saso, Nicholas Butterfield, Isabelle Thomassin-Naggara, Alan Farthing, J Richard Smith, Nishat Bharwani
Treatments for gynecologic cancer usually result in loss of fertility due to surgery or radical radiation therapy in the pelvis. In countries with an established screening program for cervical cancer, the majority of gynecologic malignancies occur in postmenopausal women. However, a substantial number of affected women are of childbearing age and have not completed their families. In these younger women, consideration of fertility preservation may be important. This article describes the fertility-sparing treatment options that are currently available and outlines the role of imaging in the selection of eligible patients on the basis of a review of the literature...
November 2016: Radiographics: a Review Publication of the Radiological Society of North America, Inc
https://www.readbyqxmd.com/read/27818263/brief-report-a-second-primary-endodermal-sinus-tumor-nine-years-after-initial-diagnosis
#10
Lea A Moukarzel, Kimberly Levinson, Francis C Grumbine
BACKGROUND: Ovarian yolk sac tumors (YST) are rare malignant germ cell tumors known to present unilaterally, allowing for fertility sparing surgical treatment with adjuvant chemotherapy. The few published cases of bilateral ovarian involvement were at the time of original diagnosis in patients with widely metastatic disease. We present this first case of bilateral ovarian YSTs, diagnosed several years apart, and discuss the implications on recurrence and tumor marker surveillance for these tumors...
November 3, 2016: Journal of Pediatric and Adolescent Gynecology
https://www.readbyqxmd.com/read/27809692/a-rare-case-of-bilateral-synchronous-spermatocytic-tumours-in-a-young-man-seeking-fertility-preservation
#11
Peter Østergren, Simpa S Salami, Aaron Udager, Jens Sønksen, Dana Ohl, Ganesh S Palapattu
Spermatocytic tumours are a rare form of testicular germ cell tumour that normally present in older men. This report presents a case of bilateral spermatocytic tumours in a 25-year-old man. The potential preservation of gonadal function, i.e. fertility and androgen production, is discussed, although this was not possible in this case. Although spermatocytic tumours are considered rare, the tumour is more common than previously thought and presents equally in older and younger men. In cases of bilateral presentation, accurate histological evaluation may allow the option of testis-sparing surgery...
November 4, 2016: Scandinavian Journal of Urology
https://www.readbyqxmd.com/read/27804040/oncologic-and-obstetric-outcomes-and-complications-during-pregnancy-after-fertility-sparing-abdominal-trachelectomy-for-cervical-cancer-a-retrospective-review
#12
Kaoru Okugawa, Hiroaki Kobayashi, Kenzo Sonoda, Eisuke Kaneki, Yoshiaki Kawano, Nobuhiro Hidaka, Katsuko Egashira, Yasuyuki Fujita, Hideaki Yahata, Kiyoko Kato
BACKGROUND: Trachelectomy was developed as a fertility-sparing surgery for early-stage cervical cancer in patients of childbearing age. The purpose of this study is to evaluate oncologic and obstetric outcomes and complications after abdominal trachelectomy. METHODS: We began to perform abdominal trachelectomy in 2005. Our institutional review board approved this clinical study, and fully informed consent was obtained from each patient. The medical records of patients who underwent trachelectomy were retrospectively reviewed...
November 1, 2016: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/27795832/fertility-sparing-management-in-cervical-cancer-balancing-oncologic-outcomes-with-reproductive-success
#13
REVIEW
Karla Willows, Genevieve Lennox, Allan Covens
BACKGROUND: Cervical cancer is the fourth most common cancer among women worldwide, many of who are still within their reproductive lifespan. Advances in screening and treatment have increased the 5-year survival for early stage disease to over 90 % in developed countries. The focus is now shifting to reducing morbidity and improving fertility outcomes for cervical cancer patients. Radical trachelectomy with lymph node assessment became the standard of care for selected women with lesions <2 cm who desire fertility preservation...
2016: Gynecologic Oncology Research and Practice
https://www.readbyqxmd.com/read/27790635/fertility-sparing-management-of-large-cell-neuroendocrine-tumour-of-cervix-a-case-report-review-of-literature
#14
S Rajkumar, R Iyer, G Culora, G Lane
Large cell neuroendocrine cervical carcinoma (LCNEC) is a rare and aggressive cancer that tends to spread and recur early despite intensive multimodal treatment. Conventional treatment strategies for early stage neuroendocrine tumour (NET) include radical hysterectomy followed by adjuvant chemotherapy. There are only 2 reported cases of fertility sparing treatment for NET. We report on the first case of successful conception and delivery at term following radical trachelectomy for early stage LCNEC.
November 2016: Gynecologic Oncology Reports
https://www.readbyqxmd.com/read/27780698/management-of-borderline-ovarian-tumours
#15
REVIEW
David M Gershenson
Approximately 3000 American women are diagnosed with borderline ovarian tumours annually. Borderline tumours are similar to other types of adnexal masses. Prognostic factors include the International Federation of Gynecology and Obstetrics (FIGO) stage, presence of peritoneal implants, micropapillary pattern (for serous histology), microinvasion and intra-epithelial carcinoma (for mucinous histology). Approximately 65-70% of serous tumours and 90% of mucinous tumours are stage I, and 30% and 10%, respectively, are associated with extra-ovarian spread...
October 3, 2016: Best Practice & Research. Clinical Obstetrics & Gynaecology
https://www.readbyqxmd.com/read/27738824/post-resection-outcomes-for-pediatric-ovarian-neoplasm-is-ovarian-preserving-surgery-a-good-option
#16
Nima Azarakhsh, Sandra Grimes, Pranit N Chotai, Claudette Shephard, Eunice Y Huang
PURPOSE: Pediatric surgeons often care for children with ovarian tumors. Few studies report long-term outcomes for these patients. This study characterizes intermediate-term results for patients who underwent surgical resection of ovarian neoplasms as children. METHODS: Patients who underwent surgery for ovarian neoplasms at a children's hospital were identified. They were invited to participate in a telephone-based survey assessing post-surgical recurrence, dysmenorrhea, quality of life, and fertility...
October 13, 2016: Pediatric Surgery International
https://www.readbyqxmd.com/read/27738663/fertility-sparing-surgery-in-gestational-trophoblastic-neoplasia-a-report-of-4-cases
#17
Malihe Hasanzadeh, Ftemeh Vahid Roodsari, Shahnaz Ahmadi, Masoumeh Gavedan Mehr, Tabari Azadeh
BACKGROUND: Gestational trophoblastic neoplasia (GTN) is a curable disease that involves the development of malignant tumor in the woman after a normal or molar pregnancy. The position of surgery in GTN is not properly specified and is changing due to new chemotherapy protocols. However, the role of surgery is highlighted in chemotherapy-resistant GTN. Other indications of surgery in trophoblastic diseases are drug toxicity and uterine perforation. Based on the fact that most women in certain age tend to preserve fertility, this study reported 4 cases of successful treatment after fertility sparing surgery...
September 2016: International Journal of Reproductive Biomedicine (Yazd, Iran)
https://www.readbyqxmd.com/read/27736798/fertility-sparing-surgery-for-patients-with-low-grade-endometrial-stromal-sarcoma
#18
Weimin Xie, Dongyan Cao, Jiaxin Yang, Xuan Jiang, Keng Shen, Lingya Pan, Huifang Huang, Jinghe Lang, Yan You, Jie Chen
PURPOSE: To assess the clinical outcomes and fertility of young women with stage I low-grade endometrial stromal sarcoma (ESS) treated with fertility-sparing surgery. RESULTS: Seventeen patients with stage I low-grade ESS (stage IA, n = 6; stage IB, n = 11) were entered into this study. Adjuvant hormone therapy was administered to 15 (88.2%) patients. At a median follow-up of 39 months (range, 4-106 months), 10 (58.8%) patients developed recurrence. All 10 patients had stage IB disease; among them, the first recurrence limited to the uterus was observed in 6 patients...
October 6, 2016: Oncotarget
https://www.readbyqxmd.com/read/27722934/ovarian-tissue-cryopreservation-and-transplantation-scientific-implications
#19
Sherman Silber
After fresh or frozen ovary transplantation, FSH levels return to normal, and menstrual cycles resume by 150 days, coincident with anti-Müllerian hormone rising to higher than normal levels. AMH then returns to well below normal levels by 240 days, remaining as such for many years with nonetheless normal ovulation and fertility. To date, 20 babies have been born in our program from 11 fresh and 13 cryopreserved ovary transplant recipients with a live baby rate of over 70 % (11 babies from fresh and 9 from frozen)...
October 8, 2016: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/27699036/neoadjuvant-chemotherapy-followed-by-conization-to-spare-fertility-in-cases-of-locally-advanced-cervical-cancer-a-case-report-and-review-of-the-literature
#20
Yanling Feng, Tiefeng Cao, Yin Wang, He Huang, Yujie Xie, Jihong Liu
The average age when cervical cancer is diagnosed is decreasing, resulting in a larger proportion of patients seeking fertility preservation. Therefore, a less radical approach that aims to preserve the potential for fertility during the treatment of cervical carcinoma is crucial. The present study reported a case of a patient with stage IB2 cervical cancer who exhibited pathological complete regression to neoadjuvant chemotherapy (NACT). This patient underwent deep cervical conization and laparoscopic lymphadenectomy to preserve her fertility...
October 2016: Molecular and Clinical Oncology
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